LOCUS       NZ_CP019458            21188 bp    DNA     linear   CON 05-MAR-2024
DEFINITION  Streptomyces autolyticus strain CGMCC0516 chromosome, complete
            genome.
ACCESSION   NZ_CP019458
VERSION     NZ_CP019458.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces autolyticus
  ORGANISM  Streptomyces autolyticus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10029028)
  AUTHORS   Yin,M., Jiang,M., Ren,Z., Dong,Y. and Lu,T.
  TITLE     The complete genome sequence of Streptomyces autolyticus CGMCC 0516,
            the producer of geldanamycin, autolytimycin, reblastatin and
            elaiophylin
  JOURNAL   J Biotechnol 252, 27-31 (2017)
   PUBMED   28472671
REFERENCE   2  (bases 1 to 10029028)
  AUTHORS   Yin,M., Jiang,M. and Lu,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JAN-2017) Yunnan University, Yunnan University, 2#
            Cuihu Beilu, Kunming, Yunnan 650091, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT Analysis v. 2.3.0
            Genome Coverage                   :: 279x
            Sequencing Technology             :: Illumina; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 03:05:38
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,227
            CDSs (total)                      :: 8,141
            Genes (coding)                    :: 7,920
            CDSs (with protein)               :: 7,920
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 221
            CDSs (without protein)            :: 221
            Pseudo Genes (ambiguous residues) :: 0 of 221
            Pseudo Genes (frameshifted)       :: 74 of 221
            Pseudo Genes (incomplete)         :: 182 of 221
            Pseudo Genes (internal stop)      :: 9 of 221
            Pseudo Genes (multiple problems)  :: 42 of 221
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:31:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1937039
            Orig. end                         :: 1958227
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP019458.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21188
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="13"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21188
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21188
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11188](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11188
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(1056..2564)
                     /locus_tag="BV401_RS07420"
                     /old_locus_tag="BV401_07405"
     CDS             complement(1056..2564)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058740.1"
                     /locus_tag="BV401_RS07420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_07405"
                     /product="hypothetical protein"
                     /protein_id="WP_079256555.1"
                     /transl_table=11
                     /translation="MTREPNTRLADLFGLAGWSKGELARLVNRKAAAMGHPQLATDTSR
                     VRRWIDTGETPRDPVPKVLAALFTERLGRVVTIEDLGFGRGGRAGKGQSGDGLFWPPES
                     TAAVLTEFTGMDLMFNRRGLVGAGAALAAGSAITGAMSDFLLSDPTLATDAPRTDNPLS
                     VEPVGFDRYEAAPVGSQEIDALEGSVEVFRAWDAARGGGLQRKAVVGQLNEVGGMLAYR
                     HPEHLQRRLWGVAANLAVLAGWMSHDVGLEPTAQKYFVIAAHAAREGDDRPRAGEALSR
                     AARQMVHLGRPDDALDLMKLATSGAGEQALPCTRAMFRTIEAWAQASKGHGQAARRALG
                     EAEELFVSDGDHGPAPSWMQLFNEADLHGMQGLVYRTLAEHEPAAAGIALNHAKKALRM
                     REGGRQRSQIFDHISIASACFIGDDPEQAERYARTALLTIEQNSSHRTWDRLREMYRLT
                     ARYGTSPAVRELREEIQRALPKGGAGKGGAGLKGSGSIARSAAV"
     gene            2811..3914
                     /locus_tag="BV401_RS07425"
                     /old_locus_tag="BV401_07410"
     CDS             2811..3914
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005474392.1"
                     /locus_tag="BV401_RS07425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_07410"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_079256556.1"
                     /sec_met_domain="APH (E-value: 4e-21, bitscore: 74.9,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYAASSSVSAPPRPYRRQLPGTGPYLDPAPGGRTRRTAALGPVPP
                     RGRLDLSGPQGAQLRTAITSVHRICPEFNPVQVLRRSGRSVLLIGATGRSTAVAKCLLD
                     HSPAWAERFRREIAMYRAFVRQRPPVRVPRLIAADPDNCALVIERMPGRIAAAQRHPTE
                     PPPRADLGAVLGAIRRVNQWRPPAGLFDAPIDYAVRLTRYHELGLLTDRDMGDLQKLLR
                     GVSQTCGRQTPAQFSHGDALLNNVLLSPAGPVFLDWDHAGWYLPGYDLATLWTVLGDAP
                     VTRRQISQLAQAAGPATRDSFLVNLMLVLTREIRQYETAVQRTMHDPAPVVPGAVPAGE
                     EQRLLLRRLHDDCALARRAVRAAVGTR"
     misc_feature    3944..3959
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.0"
                     /tool="antismash"
     gene            4080..6113
                     /locus_tag="BV401_RS07430"
                     /old_locus_tag="BV401_07415"
     CDS             4080..6113
                     /GO_function="GO:0042834 - peptidoglycan binding [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058742.1"
                     /locus_tag="BV401_RS07430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_07415"
                     /product="peptidoglycan recognition family protein"
                     /protein_id="WP_079256557.1"
                     /transl_table=11
                     /translation="MPESAQDSAHDANRDPSGPTRRTTLRTAGAAASAAFLLPLVAATP
                     AAHADQSRAEGAEGPPADGGALQRAFAAAAAEYGVPLSVLLGVSYLQSRWDGHRGAPSV
                     TGGYGPMHLTDAHTALLGAPHHSQGTEDARGDLARPLRVPKATVPEPRRLPARLRTLGR
                     AAELTGLSAEALRGDESANVRGGAALLAAAQKRLGLPRSEDPADWYAAVAAYSGADDAT
                     AAGVFADEVYSVIRGGASRTTADGERVSLDAAPAVAPDTRQLRTLGLASPARDPRVEAP
                     KDVSCEWLPAPYEEFGDNDYGNHDLGERPSSQSINYIVIHDTEGSWDTTLKLVQDPTYV
                     SWQYTLRSSDGHIAQHVPLKDVAWHAGNWYVNAKSIGLEHEGFLTAPDAWYTEAMYRSS
                     ARLVRYLAKRFGIPLDRQHILGHDNVPGTTTGTIPGMHTDPGPYWDWAHYFTLLGAPFQ
                     RTAGSSGGLVTIRPDYDTNRPVYTDCETAGQACAPHGSAAVRLHTAPSADAPLVKDIGL
                     RPDGSDSTTGVNDTGARAATGQQFAVAGHEGDWTAIWYLGQRAWFQNPKRRPTAVSAKG
                     LVVTPKDGAAEVAVYGRAYPEKEAYPEGVPVQAVSPLPYKLLAGQSYPLGLRTRGEYLW
                     ATTFDPAGHKVVRGQDVYYQIQFGHRVAFVRAADVTVRRSGK"
     gene            complement(6258..6758)
                     /locus_tag="BV401_RS07435"
                     /old_locus_tag="BV401_07420"
     CDS             complement(6258..6758)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058743.1"
                     /locus_tag="BV401_RS07435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_07420"
                     /product="hypothetical protein"
                     /protein_id="WP_020873536.1"
                     /transl_table=11
                     /translation="MSFLRRRSAATPTGPDFDVLAMDPGDWPGDLGAGLLPAPDGTCQG
                     VFLRYDLFGGRGPAMIIGNLPEGSPAREVAEGQPPFEVTQLLAALGNDEPVQVVDTEDS
                     PVMHEDNLLIVRRIKLSEGRISCAQFDRSDGVLVTIASWDRPITDDLYRLLKPLPAEMF
                     QQR"
     gene            complement(6820..9748)
                     /locus_tag="BV401_RS07440"
                     /old_locus_tag="BV401_07425"
                     /pseudo=""
     CDS             complement(6820..9748)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058744.1"
                     /locus_tag="BV401_RS07440"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_07425"
                     /product="AAA family ATPase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSQQNRTHRTLLERERELRAVDGALTELCGTELADRDEIRGGGVI
                     AFEGPGGVGKTALLGEARRRAVARGCTVLRARGGEHEQGAAFHVVRQLFQPVLAATGED
                     EHRRILGGWYDIVAPAVGLVVSGSGGAPDPQGVRDGLDWLVTRFTVEHAPVVMILDDVH
                     WADPESLDWLTRFASRTADLPLLLAVGYRPEDLTADVAAIRALVERQGARPHVLAPLTP
                     GGVGRIVREVLGDHADEAFCRECWAMTGGNPWEITELTAKIRDRRLKPQSENLPALREL
                     VSSARDSGLNDRLTRLGTAAVRLAWAVAVLGIEATPALTANVAGLSESEAAEKVARLVD
                     ARILAPPRPGNGTQPLEYLHPLIATAVYQAIPGAMRVAMHGQAATVVLGAGLGSAAAGR
                     HLLEMHPEGDPWVVHHLREAAREYLRAGAPDAGRRCLARALREPPALEERAAVLYELGC
                     AAQLTEPGCHRQPSAGRPRGARARPRTARGDHLPARPGVRPQRPYGGGRPGLRRRGRTR
                     HQRPHPAADADRAADVEHVPRR"
     gene            10001..11188
                     /locus_tag="BV401_RS07445"
                     /old_locus_tag="BV401_07430"
     CDS             10001..11188
                     /EC_number="4.2.3.157"
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058745.1"
                     /locus_tag="BV401_RS07445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_07430"
                     /product="isoafricanol synthase"
                     /protein_id="WP_079256558.1"
                     /sec_met_domain="T1TS (E-value: 7.2e-73, bitscore: 245.3,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHTHASRPHARQSALPRRAALFDFPASADLSPDTGAARQHTIQWL
                     SRFRVFENHASVEEYDALRFDVLTGLFYPRATGADLNLGSDLVGWYFVFDDQFDGELGC
                     RPEEVARLVADVIRVTEEDTAPGGTGGGEGPLLESFRDLWHRINSGRPRVWRDRFRHHW
                     LEYLHSYHREALERTGAAPADGGGDAPRSVEDVLALRRHSIGVQPCLDLNEPFGGYTLP
                     PALHGGFPLARMREATDDVVVFTNDIASLDKELAVGDVHNSVIVQWKLAGGGVEDAVRH
                     IAGLANARYGWFEETAARLPELLAEAGADPGTHRAVGRYVDGMRHVMTGNLGWSLRTAR
                     YDERGTEAVSGGRERPWARLTGAEDLIRAGRGAPPPPGSGPDTRQPMPSEPSQLA"
     gene            complement(11176..13008)
                     /locus_tag="BV401_RS07450"
                     /old_locus_tag="BV401_07435"
     CDS             complement(11176..13008)
                     /NRPS_PKS="Domain: AMP-binding (25-478). E-value: 4.6e-88.
                     Score: 287.5. Matches aSDomain:
                     nrpspksdomains_BV401_RS07450_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058746.1"
                     /locus_tag="BV401_RS07450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_07435"
                     /product="AMP-dependent synthetase/ligase"
                     /protein_id="WP_079256559.1"
                     /sec_met_domain="AMP-binding (E-value: 1.9e-84, bitscore:
                     282.5, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MREFSLPRMVETLRAGGLADSVYELADREPDRIQFARRHATEPGR
                     WTPVTAAAFRDEVLALAKGLLAEGVRFGDRVALMARTRYEWTLFSYALWSVGAQVVTVY
                     PTSSPEQVRWILAQTRAVAVVVEGEDDAMTVGAVCDALPGLRSIWQMDQGCVTELWQRG
                     AGVHGELVVERRWLVEPRSTAVICYTSGTTGQPLGCMITHANLAAECDTLFAGWNGLFA
                     EPGVQPAILAFLPLAHIYGLMVQVLCVRGGILMGHEPELSPSTLLPSLQSFRPTCVFAV
                     PYIFERILGAARNSAQDDGKRGVFEKAMDTAVRYATALEKQAQGAGKGPGPGLRAAHAV
                     FDHMVYRRIRAVLGGRVRYAVTGGSPFSRELGLAFAGAGITVYNGYGLTETTAAITAQP
                     PGRPRQGTVGRPMPGTAVRIAPDGEVWVRGGTVFAGYVDEPAATGAALSDGWLRTGDIG
                     FLDGDGYLTITGRKKDIIITSGGKSVSPQPLEERLRAHPLISQCVLVGDNRPYVGALIT
                     LDAEMLRRWHQAVGARLPVGREHAAANKALHEEIQQAVSAANRSVSRAESIRAFRILPK
                     EFTVADGLLTPSLKLRRDAVYKVCAAQIEQLYAS"
     aSDomain        complement(11575..12933)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BV401_RS07450_AMP-binding.1"
                     /evalue="4.60E-88"
                     /label="BV401_RS07450_AMP-binding.1"
                     /locus_tag="BV401_RS07450"
                     /protein_end="478"
                     /protein_start="25"
                     /score="287.5"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="ADREPDRIQFARRHATEPGRWTPVTAAAFRDEVLALAKGLLAEGV
                     RFGDRVALMARTRYEWTLFSYALWSVGAQVVTVYPTSSPEQVRWILAQTRAVAVVVEGE
                     DDAMTVGAVCDALPGLRSIWQMDQGCVTELWQRGAGVHGELVVERRWLVEPRSTAVICY
                     TSGTTGQPLGCMITHANLAAECDTLFAGWNGLFAEPGVQPAILAFLPLAHIYGLMVQVL
                     CVRGGILMGHEPELSPSTLLPSLQSFRPTCVFAVPYIFERILGAARNSAQDDGKRGVFE
                     KAMDTAVRYATALEKQAQGAGKGPGPGLRAAHAVFDHMVYRRIRAVLGGRVRYAVTGGS
                     PFSRELGLAFAGAGITVYNGYGLTETTAAITAQPPGRPRQGTVGRPMPGTAVRIAPDGE
                     VWVRGGTVFAGYVDEPAATGAALSDGWLRTGDIGFLDGDGYLTITGRKKDIIIT"
     CDS_motif       complement(11674..11742)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BV401_RS07450_0002"
                     /evalue="5.20E-04"
                     /label="NRPS-A_a6"
                     /locus_tag="BV401_RS07450"
                     /protein_end="445"
                     /protein_start="422"
                     /score="12.5"
                     /tool="antismash"
                     /translation="GEVWVRGGTVFAGYVDEPAATGA"
     CDS_motif       complement(12400..12459)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BV401_RS07450_0001"
                     /evalue="3.50E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="BV401_RS07450"
                     /protein_end="203"
                     /protein_start="183"
                     /score="22.7"
                     /tool="antismash"
                     /translation="AVICYTSGTTGQPLGCMITH"
     misc_feature    12982..13000
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.39"
                     /tool="antismash"
     misc_feature    13138..13150
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.5"
                     /tool="antismash"
     misc_feature    13156..13171
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.23"
                     /tool="antismash"
     misc_feature    13193..13205
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.41"
                     /tool="antismash"
     gene            complement(13456..13701)
                     /locus_tag="BV401_RS07455"
                     /old_locus_tag="BV401_07440"
     CDS             complement(13456..13701)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003987990.1"
                     /locus_tag="BV401_RS07455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_07440"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_069871390.1"
                     /transl_table=11
                     /translation="MADTTTTEQPLTGSGEKPELDLSGAQWRSSSQGVGDVEIAFVEGF
                     IAMRHGRRPEDPALIFTPGEWRAFVLGAREGEFDLT"
     gene            complement(13795..14961)
                     /locus_tag="BV401_RS07460"
                     /old_locus_tag="BV401_07445"
     CDS             complement(13795..14961)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020126125.1"
                     /locus_tag="BV401_RS07460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_07445"
                     /product="thiolase domain-containing protein"
                     /protein_id="WP_079256560.1"
                     /transl_table=11
                     /translation="MTKEPVAVVGIGQTKHTAARRDVSIAGLVREAAVRALDDAQLGWA
                     DIDAVVIGKAPDFFEGVMMPELYLADALGAVGKPMLRVHTAGSVGGSTALVASGLIAAR
                     VHRTVLTLAFEKQSESNAMWGLSLPIPFQQPLLAGAGGFFAPHVRAYMRRTGAPPGIGA
                     LVAYKDRRNALRNPYAHLHEHDLTLERVRSSPMLWDPIRYSETCPSSDGACAMVLTDRA
                     GADRAPYPPAWMHGGAMRSEPTLFAGKDFVSPRAGRDCAADVYRQAGITDPRREIDAVE
                     MYVPFSWYEPMWLENLGFADEGAGWKLTESGVTEIDGELPVNPSGGVLSTNPIGASGML
                     RFAEAALQVRGRAGEHQVDGARKALGHAYGGGSQFFSMWVVADTPPES"
     gene            complement(14958..16025)
                     /locus_tag="BV401_RS07465"
                     /old_locus_tag="BV401_07450"
     CDS             complement(14958..16025)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058749.1"
                     /locus_tag="BV401_RS07465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_07450"
                     /product="thiolase domain-containing protein"
                     /protein_id="WP_079256561.1"
                     /transl_table=11
                     /translation="MREVAIVAFGQSDHRRDTAEISEVEMLMPVLHQVLDAVGLRAGEI
                     DFTCSGSCDYLAGRAFSFTMTLDGVGAWPPISESHVEMDGAWALYEAWTRLLTGEAETA
                     LVYSYGKSSPGDPREVLTRQLDPYYVAPLWPDSVSLAALQAQALLDAEDTGADERALAG
                     VAARSRTAAEGNPHAQLTGSPPPEALLEDPYVVRPLRRHDCPPVGDGAAAVVLAAGDTA
                     RRLCRRPAWIRGIDHRTEAHSLGVRDLTRSPSTRLAAERAGAFEAPVDLAELHAPFTSQ
                     ELILRRELRLGEGVRVNPSGGALAANPLMAAGLIRLGEAAAAIHRGAADRTLAHATSGP
                     CLQQNLVAVLEGDDT"
     gene            complement(16026..16985)
                     /locus_tag="BV401_RS07470"
                     /old_locus_tag="BV401_07455"
     CDS             complement(16026..16985)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058750.1"
                     /locus_tag="BV401_RS07470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_07455"
                     /product="OB-fold nucleic acid binding domain-containing
                     protein"
                     /protein_id="WP_079256562.1"
                     /transl_table=11
                     /translation="MTPAPSPEALQAPLVVEFPFTRSLGPVQSAFLTGLRERTVLGVRT
                     TDGRVLMPPVEYDPVTADELSDLVEVAPTGTVTTWAWNPSPRRGQPLPTPFAWVLVRLD
                     GADTALLHALDAPGPDAVRTGMGVRIRWAGERVGAITDIACFEPYDGAGGGRAVPHRGE
                     FTDPVDGIVAPARLDYTYAPGRAQSRYLKALAGRTIYGERCPSCRKVYVPPRGACPTCG
                     VATDEQVEVGPRGTVTTFCIVNIKARNLDIEVPYVYAHIALDGADLALHARIGDIPYDE
                     VRMGLRVEPVWSGDGRYPDHYRPTGEPDADYDTYKELL"
     gene            complement(17047..17853)
                     /locus_tag="BV401_RS07475"
                     /old_locus_tag="BV401_07460"
     CDS             complement(17047..17853)
                     /NRPS_PKS="Domain: ECH (14-260). E-value: 3.5e-50. Score:
                     162.5. Matches aSDomain:
                     nrpspksdomains_BV401_RS07475_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014173688.1"
                     /locus_tag="BV401_RS07475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_07460"
                     /product="crotonase/enoyl-CoA hydratase family protein"
                     /protein_id="WP_069871380.1"
                     /transl_table=11
                     /translation="MTSGTEHLIVERVGATLVLTLNRPEARNALSLPMLVGLYDGWTEA
                     DEDDTVRSVVLTGAGGAFCAGMDLKALAGGGRMAGEHVRDRLAADPDLHWKAMLRHHRP
                     RKPVIAAVEGPCVAGGTEILQGTDIRVAGRGATFGLFEVRRGLFPIGGSTVRLTRQLPR
                     THALEMLLTGRPYPAEEAARIGLIGHVVPDGTALEKALEIAELINANGPLAVEAVKASV
                     YETAEMTETDGLKSELERGWPIFDTADAKEGSKAFAEKRPPVYRRA"
     aSDomain        complement(17074..17811)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BV401_RS07475_ECH.1"
                     /evalue="3.50E-50"
                     /label="BV401_RS07475_ECH.1"
                     /locus_tag="BV401_RS07475"
                     /protein_end="260"
                     /protein_start="14"
                     /score="162.5"
                     /tool="antismash"
                     /translation="ATLVLTLNRPEARNALSLPMLVGLYDGWTEADEDDTVRSVVLTGA
                     GGAFCAGMDLKALAGGGRMAGEHVRDRLAADPDLHWKAMLRHHRPRKPVIAAVEGPCVA
                     GGTEILQGTDIRVAGRGATFGLFEVRRGLFPIGGSTVRLTRQLPRTHALEMLLTGRPYP
                     AEEAARIGLIGHVVPDGTALEKALEIAELINANGPLAVEAVKASVYETAEMTETDGLKS
                     ELERGWPIFDTADAKEGSKAFAEK"
     gene            18019..19689
                     /locus_tag="BV401_RS07480"
                     /old_locus_tag="BV401_07465"
     CDS             18019..19689
                     /NRPS_PKS="Domain: AMP-binding (8-435). E-value: 1.6e-68.
                     Score: 223.1. Matches aSDomain:
                     nrpspksdomains_BV401_RS07480_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058752.1"
                     /locus_tag="BV401_RS07480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_07465"
                     /product="acyl-CoA synthetase"
                     /protein_id="WP_079256563.1"
                     /sec_met_domain="AMP-binding (E-value: 1.7e-71, bitscore:
                     239.9, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYNLADLFESIVDTVPDREALVYIDHPGTGAERRLSYAQLDAAA
                     NRLAHHLGDSGIAPGEHVGLHLCNGVEYLQTALACLKIRAVPVNVNYRYVEDELVYLYR
                     DADLAALVYDAEFGERVAAALPHTGTLRHLVRVGTGHGPRASVAFGDAEASGSPERGFP
                     ARSADDRFIIYTGGTTGMPKGVVWRQEDLFFSGLGGGAPTGRPVGRPEELAERVAAGGE
                     GLAFFPTPPLMHGTSTLTAFIAFNFGQKVVLHRKFMPEEVLRTIEKEKVTAASLVGDAM
                     LRPLVDALTGPLQGTDLSSLLSVSSSGAILSETVRAQFAELAPHTLLLNNFGSSESGFN
                     GTATADSGPEKGFRLRVNARTTVVDPATLTPVAPGEPGRIAQRGHVPLGYYNDPKKTAE
                     TFFETDGERWVLLGDMATVDEEGVITVLGRGSQCINTGGEKVYPEEVEQALKAHPEVYD
                     ALVAGVPDTRWGHRVAAVVQPRTPASGLTADAVRDHCRERLAGYKIPRTVVFTDHIQRS
                     PSGKADYRWARAVAQGTDGETPHQDRDAPHQDRGAPHPG"
     aSDomain        18043..19323
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BV401_RS07480_AMP-binding.1"
                     /evalue="1.60E-68"
                     /label="BV401_RS07480_AMP-binding.1"
                     /locus_tag="BV401_RS07480"
                     /protein_end="435"
                     /protein_start="8"
                     /score="223.1"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FESIVDTVPDREALVYIDHPGTGAERRLSYAQLDAAANRLAHHLG
                     DSGIAPGEHVGLHLCNGVEYLQTALACLKIRAVPVNVNYRYVEDELVYLYRDADLAALV
                     YDAEFGERVAAALPHTGTLRHLVRVGTGHGPRASVAFGDAEASGSPERGFPARSADDRF
                     IIYTGGTTGMPKGVVWRQEDLFFSGLGGGAPTGRPVGRPEELAERVAAGGEGLAFFPTP
                     PLMHGTSTLTAFIAFNFGQKVVLHRKFMPEEVLRTIEKEKVTAASLVGDAMLRPLVDAL
                     TGPLQGTDLSSLLSVSSSGAILSETVRAQFAELAPHTLLLNNFGSSESGFNGTATADSG
                     PEKGFRLRVNARTTVVDPATLTPVAPGEPGRIAQRGHVPLGYYNDPKKTAETFFETDGE
                     RWVLLGDMATVDEEGVITVLGRGSQCIN"
     CDS_motif       18529..18579
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BV401_RS07480_0001"
                     /evalue="6.80E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="BV401_RS07480"
                     /protein_end="187"
                     /protein_start="170"
                     /score="18.7"
                     /tool="antismash"
                     /translation="FIIYTGGTTGMPKGVVW"
     CDS_motif       19174..19221
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BV401_RS07480_0002"
                     /evalue="2.50E-04"
                     /label="NRPS-A_a6"
                     /locus_tag="BV401_RS07480"
                     /protein_end="401"
                     /protein_start="385"
                     /score="13.5"
                     /tool="antismash"
                     /translation="VPLGYYNDPKKTAETF"
     misc_feature    complement(20075..20089)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.19"
                     /tool="antismash"
     gene            20092..20610
                     /locus_tag="BV401_RS07485"
                     /old_locus_tag="BV401_07470"
     CDS             20092..20610
                     /EC_number="2.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014155970.1"
                     /locus_tag="BV401_RS07485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_07470"
                     /product="GNAT family protein"
                     /protein_id="WP_069871539.1"
                     /transl_table=11
                     /translation="MRTAVEDDAEALADAYTRNREHLRPSSPRRDESFFTADGQAARLR
                     DQLEQWESGRMVPWVLTGGERILGTVTLSHIVLGPWRNGHLGYWIDAGHLGRGLASLAV
                     RSVCRVADERLGLHRIEASTLVENVPSQGVLLRCGFTRIGMAPDYLHIAGAWRDHLLFQ
                     RVLHDRPAA"
     misc_feature    21058..21072
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
ORIGIN
        1 agcgggcggt gcgcgaaagc cgggacaccc tgcgccacca gcggcggatc gcgcggaccg
       61 agcgccggct cgcggtggag gtgcaggagg ccgtgctgcc gccgtggcgc ggctccctcc
      121 ggcttccggc ccgtgacggc tttccgggcg ccgaaccacc ggatgacggc gccgccctcg
      181 acctcgccgc ccactacctg ccctccgagt ccagcgcccg gatcggcggc gactggtacg
      241 acgcgctgga actgccggac ggccggaccc tgctgagcgt cggcggcctc accggccatg
      301 gagtgaccgc gacctgcggt atggccatgc tgctcggcgc ggtgcgcggc atggcggtgg
      361 ccgggatcga gccgggcccg ctgatgggtc ggctcaacca actgctcgcc gtatcctccc
      421 agcccgcgct ggtcggcgcc gtctgcggac agtacgaccc ggacacccgc accctgctct
      481 gggcacaggc cggacacccc gccccgctgc tcttccgcga cgggacaggg cgcccgctgc
      541 gctctcccga aggcgtgctg ctgggcgcca cgacgggcgc cgcgtacgcc caggccgagg
      601 agcggctgga gccgggcgat ctgctggtgc tgcacaccgg acggctcgcc cgggacgccg
      661 agggcgccac cgagcggctg ctcgcgctcg cgccacggct gaccgccgcc catggcgccc
      721 aggagtgcgt acggaccgtg gccgaggcgt tcggcgacga gccgcgtgcg aacgacgcct
      781 gtgtgctgat cgccagggtc accgccgccc gcgcatgacg cggcttcccg cgtcggcatg
      841 acgcggtgat cgacccctcg taagcggtgc ccgacctcgt aaggcgtcgc accgcgtaag
      901 gcgtgacccc cgtaaggcgt cgactccccg taagacgttg ccccgcgtaa agcccttcgt
      961 acggcccctc cggcccttcg tcatgcccct cgtaaggcaa gcccctcgta gcgcgagcaa
     1021 gctcctcgta agccccgtga ggcgtggccc ggacgctaga cggccgcgct cctggcgatg
     1081 gagccggatc ctttcagccc cgcgccgccc tttcccgcgc ctcccttcgg cagcgcccgc
     1141 tggatctcct cccgcagctc ccggacggcc ggtgaggtgc cgtaccgcgc ggtgagccgg
     1201 tacatctcgc gcagccggtc ccaggtgcga tgcgaggagt tctgctcgat cgtcagcagg
     1261 gccgtccggg cgtagcgctc ggcctgctcg gggtcgtcgc cgatgaaaca ggccgaggcg
     1321 atggagatgt ggtcgaagat ctgggaccgc tggcgcccgc cctcccgcat ccgcagcgcc
     1381 ttcttcgcat ggttcagggc gatccccgcc gccgccggct cgtgctcggc gagggtgcgg
     1441 tagaccagcc cctgcatccc gtgcagatca gcctcgttga acagctgcat ccagctgggc
     1501 gccggcccgt ggtccccgtc ggagacgaac agctcctccg cctcgcccag ggcgcgccgc
     1561 gccgcctggc cgtggccctt ggacgcctgc gcccatgcct cgatggtgcg gaacatggcc
     1621 cgggtgcacg gcagcgcctg ctcgcccgca ccggacgtgg ccagcttcat cagatccagc
     1681 gcgtcgtccg ggcggcccag gtgcaccatc tgccgggcgg cccgggagag cgcctcgccc
     1741 gcccggggcc ggtcgtcgcc ctcgcgggcc gcgtgcgcgg cgatgacgaa gtacttctgg
     1801 gcggtcggct ccaggccgac gtcatgggac atccagccgg cgagcaccgc cagattggcc
     1861 gccacccccc acagtcggcg ctgaaggtgt tcggggtggc ggtaggcgag catgccgccc
     1921 acctcgttga gctggccgac cacggccttg cgctggagtc cgccgccgcg ggccgcgtcc
     1981 caggcgcgga agacctcgac cgatccctcc agggcgtcga tctcctggga gcccacgggg
     2041 gcggcctcat agcggtcgaa gcccacgggc tcgacggaca gggggttgtc ggtacggggc
     2101 gcgtcggtgg cgagggtggg gtcggagagc agaaagtcgc tcatggcacc ggtgatggcg
     2161 gatcctgcgg cgagcgcggc gcccgcaccc accaagccgc gtcggttgaa cataaggtcc
     2221 attcccgtga attcggtgag gaccgcggcg gtggactcgg gcggccagaa cagcccgtcg
     2281 ccggactgcc cctttcccgc gcgccccccg cgtccgaacc cgagatcctc gatggtcacg
     2341 actcgaccga ggcgctcggt gaacagggcc gccagcacct tgggcacggg atcgcgcggc
     2401 gtctcgccgg tgtcgatcca acgccgcacc cgcgaggtgt cggtcgccag ctgcggatgg
     2461 cccatggccg ccgccttccg gttcacgagt ctcgcgagtt cccccttgga ccatccggcg
     2521 aggccgaaca ggtccgcaag acgggtgttg ggttccctcg tcacgtcaag cccccaggtt
     2581 cctcggctga cttgacagta acggccccgt cacgagcggt gcgactattc gccagggttc
     2641 gccagggtcc gccagatggt gtgccacccg cacacgggtg tgatgtagga gcgcgttacc
     2701 cggcccggtg gcggctcgcg ctggatcggc cgcattcccc agggtgcggc cccgccccgg
     2761 ggccgggtgc gtacgcaatt cgtcggcaca cgaagggatc tgtatcgccc atgtacgcag
     2821 catcgtcctc cgtgtccgcc ccgccccggc cgtaccggcg gcagctgccc ggcactgggc
     2881 cgtacctcga tcccgccccc ggcggccgga cccggcggac cgccgccctc ggccccgtgc
     2941 cgccccgcgg gagactcgat ttgtccggtc cacagggtgc gcagctgcgc accgcgatca
     3001 cctcggtcca tcgcatctgt ccggagttca acccggtgca ggtgctgcgg cgcagcggcc
     3061 ggtccgtgct tctgatcggc gcgaccgggc gcagcaccgc ggtggccaag tgtctgctgg
     3121 accactcccc cgcgtgggcc gagcggttcc gccgggaaat agcgatgtac cgggcgttcg
     3181 tccgccagcg cccgccggtg cgggtgcccc ggctgatcgc cgccgacccg gacaactgcg
     3241 cgctggtcat cgagcggatg cccgggcgga tcgcggccgc gcagcgccac cccaccgaac
     3301 ctccgccgcg cgccgatctg ggggccgtgc tgggcgcgat ccgccgggtc aaccagtggc
     3361 gcccgcccgc cggtctgttc gacgccccca tcgactacgc cgtccggctg acccgctatc
     3421 acgagctcgg gctgctcacc gaccgggaca tgggcgatct acagaagctg ctgcgcggcg
     3481 tctcgcagac ctgtgggcgg cagaccccgg cccagttctc ccatggcgac gccctgttga
     3541 acaatgtcct gctctccccc gcgggcccgg tgttcctcga ctgggaccac gcgggctggt
     3601 atctgcccgg ctatgacctg gccacgctgt ggacggtgct gggcgacgcc cccgtgaccc
     3661 ggcgccagat cagccagctg gcgcaggccg cgggcccggc cacgcgggat tccttcctgg
     3721 tgaatctgat gctggtgctg acgcgggaga tccgccagta cgagaccgcg gtgcagcgca
     3781 ccatgcacga ccccgccccg gtggtgccgg gcgcggttcc ggccggtgag gagcagcggc
     3841 tgctgctgcg ccggctgcat gacgactgcg cgctggcccg gcgcgcggtg cgggcggcgg
     3901 tcggcacccg ctgagcggag gcggagtggc gtccgggcgc gtcaccggtc tggaccggtg
     3961 acgcgccgca ggcggaccga catccgaacg tccgtccggg tgacggcgat tgacgccacg
     4021 cctggcagcg catatctcta agtggctcgg ctcgccccgg cccgcttgag gaggctgcaa
     4081 tgccagaatc cgcacaggac agcgcccacg acgcgaacag agatccgtcc ggtcccaccc
     4141 ggcgaaccac actgcggacc gcgggagccg cggcgtccgc ggcgtttctg ctcccgttgg
     4201 tcgcggcgac acccgcggcc catgccgacc agtcacgggc cgagggggcc gagggtcctc
     4261 cggccgacgg cggcgcattg cagcgtgcct tcgcggccgc ggccgccgag tacggcgttc
     4321 cgctgagcgt gctcctgggc gtctcgtatc tccagtcgcg ctgggacggc caccgcggtg
     4381 cgccgagcgt caccggcggc tatggcccca tgcatctcac cgacgcccac accgccctgc
     4441 tcggcgcccc gcaccacagc cagggcaccg aggacgcgcg cggcgatctc gcccggcccc
     4501 tgcgggtccc caaggccacc gttcccgagc cccggcggct gcctgcgcgg ctgcgcaccc
     4561 tcggccgggc cgcggagctc accgggctgt ccgcggaggc gctgcgcggc gatgagagcg
     4621 ccaatgtgcg cggtggcgcg gccctgctgg ccgccgccca gaagcggctg gggctgccgc
     4681 ggagcgagga ccccgccgac tggtacgcgg cggtggcggc ctactcgggc gccgacgacg
     4741 ccacggccgc gggcgtcttc gccgacgagg tgtactcggt gatccgcggc ggtgcctcgc
     4801 ggacgaccgc cgacggcgag cgggtctccc tcgacgcggc gcccgctgtc gcgccggaca
     4861 cccggcagct gcggacgctc ggtctggcct cccccgcccg ggatccgcgg gtcgaggccc
     4921 ccaaggacgt gtcctgcgag tggctcccgg cgccctacga ggagttcggg gacaacgact
     4981 acggcaacca cgacctgggc gagcgcccct cctcgcagtc catcaactac atcgtcatcc
     5041 atgacaccga gggctcctgg gacaccaccc tcaagctggt ccaggacccc acctatgtgt
     5101 cctggcagta caccctgcgc tcctccgacg gccatatcgc ccagcatgtg ccgctgaagg
     5161 acgtcgcctg gcacgcgggc aactggtacg tcaacgccaa gtccatcggc ctggagcacg
     5221 agggtttcct caccgccccg gacgcctggt acacggaggc gatgtaccgc tcctcggcgc
     5281 ggctggtgcg ctatctcgcc aagcggttcg gcattccgct ggaccgccag cacatcttgg
     5341 gtcatgacaa tgtgccgggc accaccaccg gcaccatccc gggcatgcac accgacccgg
     5401 gcccctactg ggactgggcg cactacttca ccctgctcgg cgcgcccttc caacgcaccg
     5461 ccggctcctc cggcggcctg gtcaccatcc gccccgacta cgacaccaac cggcccgtct
     5521 acaccgactg cgagacggcg ggccaggcat gcgccccgca cggctcggcc gcggtgcggc
     5581 tgcacaccgc gccgagcgcg gacgccccgc tggtcaagga catcgggctg cgcccggacg
     5641 gctccgactc gacgaccggt gtcaatgaca ccggggcccg tgccgccacc gggcagcagt
     5701 tcgcggtcgc ggggcacgag ggcgactgga cggcgatctg gtacctcggc caacgcgcct
     5761 ggttccagaa ccccaagcgg cggccgacgg ccgtgagcgc caagggactt gtggtgacac
     5821 ccaaggacgg ggcggcggag gtcgcggtgt acggccgcgc ctatccggag aaggaggcgt
     5881 atccggaggg cgtgccggtg caggcggtct cgccgctgcc gtacaagctg ctcgccgggc
     5941 agtcctatcc gctggggctg cggacgcggg gcgagtatct gtgggcgacg accttcgatc
     6001 cggccggtca caaggtggtg cgcggccagg atgtgtacta ccagatccag ttcgggcacc
     6061 gggtggcgtt cgtccgggcc gccgatgtga cggtccggcg ctccgggaag tgaggctgat
     6121 gggtcagtgg gcctgatgga tcgatgggcc tgatgggccg tcaatccgcc gtggaggagc
     6181 ggtagaagag gggccgtggg cgcggccgta ccgacctcgt gccgtacggg cgtctcacgg
     6241 cccttcgcgg cggcccctca gcgctgctgg aacatctccg cgggcagcgg cttgagcagc
     6301 cggtacagat cgtcggtgat cggccggtcc cagctggcga tggtgacgag cacaccgtca
     6361 ctgcggtcga actgggcaca ggagatccgg ccctcggaga gcttgatccg gcggacgatg
     6421 aggaggttgt cctcatgcat gaccgggctg tcctcggtgt ccaccacctg gaccggctca
     6481 tcgttcccga gcgccgccag cagctgggtc acctcgaacg gcggctgccc ctcggccacc
     6541 tccctggccg gggacccctc gggcagattg ccgatgatca tggccgggcc gcgcccgccg
     6601 aacaggtcgt agcgcaggaa gacgccctgg caggtgccgt cgggggcggg cagcagcccc
     6661 gccccgagat cgccgggcca gtctcccggg tccatggcga ggacatcgaa gtccggcccg
     6721 gtgggcgtgg cggcgctgcg gcggcggagg aaggacatgc ggacatggta cgtggccgag
     6781 cgcccgttcc cgtgccgggt ggcggacggg ccgcagccct cattcggggt cgggcaccgg
     6841 gcgctgggga aggccgacgg tgggcgtgat gagccgcttc gccagcccgg cccggtcggt
     6901 gccgacctta cggtagacat cggagagcag ccgggcgacc tcgcgctcct cgagcccggt
     6961 cgtctcgctg atccgggcgt ccggccagcc ctcggcggcc cgctcggcga tggcctgctc
     7021 ctgcgaggtc agcgggctgg tgtgatccac ccgcagctgc atcgggcgca gcccggccgc
     7081 ggacagctcg tcgcgggccc gggcggcgag cgcgtcggcc ccgcagcgca ccgctccctc
     7141 cagaccgcgg tagagccggt cgccggcctc ctggggcagg ccgatgcggc gcagcgcggc
     7201 gccgtggtcg accagcgcca gggccaggtc gtacgcggcc ggtgagcgca tcagatggct
     7261 gacggcctcg gccagcagct tgatccggtc cggcccctgg gtcacggtgg ccgcggtgtg
     7321 cagcgccttg ccgatcgcgg agtgggcgcc gaactggcgg gcgcggcgca ccgcgtcgtc
     7381 ggcgacctcg gcggcctgcc ggggatcggt gagcgcgagg gcctgggcga ggtggagctg
     7441 ccaggggcac caggcggggt tgcgcatacc gcgtccgtcc atgcggcggc cgacctcggt
     7501 gagccggttc cgggcctcgc ggtgcagatt ggcggcgagc agcagctcac cgcggaccgc
     7561 cggcacatcg gggcagagcg tggcctgcgg aagggtctcg ccacggtgcc cggccgcgaa
     7621 ctcctgcgcc tcctggatcc ggccgcggca gatcagcgtt ccgatgaggg tgccgaccgc
     7681 ggtccagtgg gcgggtgtcg aggagcccac cagatcggcg atccgcatcc cctcacgggc
     7741 cagctcctcc gcctcgccga gggcgccgcg gcgcagtcgg gcatagccga ggagggtgaa
     7801 gccgaacgcc aggtgggagc cgcgccagcc cttgcgctcg cattcggcga tgcccttgtt
     7861 gaacagctcc tcggcgcgtc cgggctggtc gcagtggagg aagaccaggg cgaccaggat
     7921 gggcacctcg aagccccagt cgtcatcggt ccagctgagg ccgtcgccga gggcctcctc
     7981 cgcgtagtgc agcgcggtgg cgacgggctc tccgcgcgtc atcgcgtccc aggcgcgcag
     8041 ccccatcaga tagcgctcgg ccatgccgcg gccggtgagg tgctccgcga gccgggtgag
     8101 ccgccgggag cgggcgggcg actccttctc atcggcgcgg aacatgttcc acatcagctg
     8161 ctcggtctgc atccgcagcc gggtgcgggc gctggtggcg cgtccgacct cgtcggcgaa
     8221 gacctgggcg gcctcctcca tacggccgct gtggccgtac gcctgggcga gccggtaggt
     8281 gatcgcctcg cgcagttcgg ggccgagcgc gggctccccg agggcggccc gcagatggtt
     8341 gacggtgaca tccgggctcg gtgagctggg cggcgcaccc cagctcgtac agcacggcgg
     8401 cgcgctcctc cagggcgggc ggttcgcgca gggcccgggc cagacagcgg cgcccggcgt
     8461 cgggtgcccc ggcgcgcaga tactcccggg cggcctcccg cagatggtgc accacccatg
     8521 ggtcgccctc ggggtgcatc tccagcagat gccggccggc cgccgcggaa cccaggcccg
     8581 cgccgagcac cacggtggcg gcctggccgt gcatggccac tctcatggcg ccggggatcg
     8641 cctggtagac ggcggtggcg atgagcgggt ggaggtactc caggggttgg gtgccgtttc
     8701 cggggcgcgg cggggccagg atccgcgcgt cgacgagccg cgccaccttt tcggcggcct
     8761 cggactcgct gagcccggcg acgttcgcgg tgagcgccgg ggtggcctcg atgccgagga
     8821 cggcgacggc ccaggcgagg cggacggcgg cggtgccgag gcgggtcagc cggtcgttga
     8881 gcccgctgtc cctggccgag gagaccagtt cgcgcagtgc gggcaggttc tccgactgcg
     8941 gtttcagcct gcggtcgcgg atcttggcgg tgagctcggt gatctcccag gggttgccgc
     9001 cggtcatcgc ccagcactca cggcagaacg cctcgtcggc gtggtccccg aggacctccc
     9061 ggacgattct gccgacgccg cccggggtga gcggggccag tacgtggggc cgtgctccct
     9121 ggcgctcgac gagggcccgt atcgcggcga cgtcggcggt caggtcctcg gggcggtagc
     9181 cgacggcgag cagcaggggc agatcggcgg tgcgcgaggc gaaccgggtc agccagtcca
     9241 gcgattcggg gtcggcccag tggacatcgt cgaggatcat gacgaccggg gcgtgctcca
     9301 cggtgaagcg ggtcaccagc cagtcgaggc cgtcgcgcac gccctgtgga tcgggtgcgc
     9361 cgccgctgcc ggagaccacc aggccgaccg cgggcgccac gatgtcgtac cagccgccga
     9421 ggatgcggcg gtgctcgtcc tcgccggtcg ccgcgagcac cggctggaag agctggcgca
     9481 ccacgtggaa ggccgcgccc tgttcgtgct cgccaccacg ggcgcggagc acggtgcagc
     9541 cgcgggcgac ggcccgccgg cgtgcctcgc cgagcagtgc ggtcttgccg acgccgccgg
     9601 gcccctcgaa ggcgatcact ccgccgccgc ggatctcgtc ccggtcggcg agttccgttc
     9661 cgcacagttc ggtcagcgcg ccgtccaccg cgcgcagctc ccgctcccgt tccagcagtg
     9721 tccggtgcgt ccggttctgt tggctcatgt actccgccac gttgcttccc ctccggcagg
     9781 tgacgccgag cgtagcgtga atggcacgct ccgtagctcc cgtatggaga gatttccgtc
     9841 cgctcttgcc actggcatgc gccaattcac cgcctcctct atcgatgcca cgttccgcac
     9901 gcgaggatga ccggattcag cgggttggcc agttgccgtg tacgcctgtg gtatatgcgg
     9961 gctcgggccg cccggacgac gaagggggcg gagacgactc atgcacacgc acgcttcgcg
    10021 accacacgcc cggcagtcgg cactgccacg acgggcggcc ctgttcgact tcccggcctc
    10081 cgccgacctc agcccggaca ccggggcggc gaggcagcac accatccaat ggctgtcacg
    10141 gttcagggtc ttcgagaacc acgcatccgt cgaggagtac gacgcgctcc gcttcgacgt
    10201 actgacggga ctgttctatc cccgggcgac cggcgccgat ctgaacctcg gcagcgacct
    10261 cgtgggctgg tacttcgtct tcgacgacca gttcgacggg gaactgggct gccgcccgga
    10321 ggaggtggca cggctggtgg cggacgtcat ccgggtcacc gaggaggaca cggcacccgg
    10381 cgggacgggc ggcggcgaag ggccgctcct ggagagcttc cgcgatctgt ggcaccggat
    10441 caactccggg cggccgcggg tgtggcggga ccgcttccgc caccactggc tggagtatct
    10501 gcactcctac caccgcgagg ccctggagcg gaccggtgcc gcgcccgcgg acggcggcgg
    10561 ggacgcgccg cgctcggtgg aggacgtgct ggccctgcgg cgccactcga tcggcgtaca
    10621 gccctgtctg gacctgaacg agccgttcgg cggctacacc ctgccgcccg cgctgcacgg
    10681 cggcttcccg ctggcccgga tgcgggaggc cacggacgat gtggtggtct tcaccaatga
    10741 catcgcctcc ctggacaagg aactggccgt cggcgacgtc cacaacagcg tcatcgtcca
    10801 gtggaagctc gcgggcggtg gagtggagga cgcggtacgc catatcgccg gcctcgccaa
    10861 cgcccgctac ggctggttcg aggagaccgc ggccaggctg ccggagctgc tggccgaggc
    10921 gggggcggat cccggcaccc accgcgcggt ggggcgctat gtggacggca tgcggcatgt
    10981 gatgacgggc aatctgggct ggtcgctgcg gacggcccgg tacgacgagc ggggcaccga
    11041 ggcggtcagc gggggacggg agcggccgtg ggcccggctg accggcgcgg aggacctgat
    11101 ccgcgcggga aggggagcgc cgccaccgcc cggcagcggc ccggacaccc gtcagccgat
    11161 gccctcggag ccctctcagc tcgcgtagag ctgctcgatc tgcgcggcgc agaccttgta
    11221 gaccgcgtcg cgccgcagct tgagcgaggg cgtcaacagc ccgtccgcca cggtgaattc
    11281 cttcgggagg atacggaagg ccctgatcga ctccgccctg gacaccgacc ggttcgccgc
    11341 cgagaccgcc tgctggatct cctcgtgcaa cgccttgttg gccgccgcgt gctcccggcc
    11401 gacgggcagc cgcgcgccga ccgcctggtg ccagcgcctc agcatctcgg cgtccagggt
    11461 gatcagcgcc ccgacgtagg ggcggttgtc gcccaccagg acgcactgcg agatcagtgg
    11521 atgcgcccgc agccgctcct ccagcggctg cggcgagacg ctcttgccgc cgctggtgat
    11581 gatgatgtcc ttcttacggc cggtgatggt caaatagccg tcgccgtcga ggaatccgat
    11641 gtctccggtg cgcagccagc cgtcgctcag cgcggccccg gtggccgccg gctcgtccac
    11701 atagcccgcg aagacggtgc cgccgcgcac ccacacctcg ccgtccggcg cgatgcgcac
    11761 cgccgtgcca ggcatcgggc ggcccaccgt gccctgccgg gggcggccgg gcggctgtgc
    11821 ggtgatcgcg gccgtcgtct cggtgaggcc gtagccgttg tagacggtga tcccggctcc
    11881 cgcgaacgcc agccccagct cccggctgaa cggggagccg ccggtgaccg cgtagcgcac
    11941 ccggccgccc agaacggctc tgatgcgccg gtagaccatg tggtcgaaga cggcgtgcgc
    12001 ggctctgagg ccggggcccg gtcccttccc ggcgccctgt gcctgcttct ccagcgccgt
    12061 ggcgtagcgc accgccgtgt ccatggcctt ctcgaagacc ccgcgcttgc catcgtcctg
    12121 ggcggagttc cgcgcggccc cgaggatccg ctcgaagatg tagggcaccg cgaagacaca
    12181 ggtcgggcgg aaggactgga gggacggcag cagggtcgac ggggagagct cgggctcgtg
    12241 tcccatgagg atgccgcccc gtacgcagag cacctggacc atcagtccgt agatgtgggc
    12301 cagcgggagg aaggcgagga tggcgggctg caccccgggc tcggcgaaca gcccgttcca
    12361 gcccgcgaag agggtgtcgc attcggcggc gagattggca tgggtgatca tgcacccgag
    12421 gggctgtccg gtggtgcccg aggtgtagca gatgaccgcc gtggagcgcg gttccacgag
    12481 ccagcgccgc tcgacgacca gttcgccgtg gacgccggcg ccgcgctgcc acagctccgt
    12541 cacgcacccc tggtccatct gccagatgga gcgcagcccg ggaagggcgt cgcagacggc
    12601 gccgaccgtc atggcgtcgt cctcgccctc gaccaccacg gccacggccc gcgtctgggc
    12661 caggatccag cgcacctgct ccggcgagga ggtggggtag acggtcacca cctgggcgcc
    12721 gacggaccac agggcatagc tgaacagcgt ccactcgtac cgtgtccgtg ccatcagggc
    12781 cacccggtcc ccgaaccgca caccctcggc cagcaggccc ttcgccagcg ccagaacctc
    12841 gtcccggaag gccgcggcgg tcaccggagt ccaccggccg ggttcggtgg cgtggcgccg
    12901 ggcgaactgg atccggtccg gttcgcggtc cgccagctcg tacaccgagt ccgccagtcc
    12961 gcccgcgcgc agagtttcca ccatgcgagg gagactgaat tcgcgcacga caccccctgt
    13021 tttcagccga gttgccgccc cgtacaacgg ggaggtggga gggaaaacta cctctcgagg
    13081 cgagggctgc atagagcgcg gacgatcctg ttccccatcg tggagacccg tcgcgacctg
    13141 ccgctgtcac cgtgagtcac gctcacgttt cggcagaagg catggaggtt tcgtgaccct
    13201 gtcgcgaagc catgggaaga cggatctcgt ggccgcgccc ggcgatgtgt ggctccaccg
    13261 gggtccgccg cgctccgatt ctggccgata acgcactcat cgccatgggt caggcaccgc
    13321 ggggccgccg acgggccttt ttgacggcgc gacatgccat gagtgagggg cgatatgcca
    13381 cggatggggg acgacatgcc acggggcggg ccgtccggtc cggccggacc cgcccgcccc
    13441 cgctggagcc ccggttcagg tgaggtcgaa ctcgccctca cgcgcgccca ggacgaaggc
    13501 gcgccactca cccggggtga agatcagcgc cgggtcttcg ggacggcggc cgtggcgcat
    13561 cgcgatgaat ccctcgacaa aggcgatctc cacatcgccc acgccctggc tgctcgaccg
    13621 ccattgggcg cccgagaggt cgagttcggg cttctccccg cttcctgtca gtggctgttc
    13681 tgtggtggtg gtatcggcca cgtcggctca tcctcccgga tcgtcgtccg cgccccaccc
    13741 tagcgatcgc ggccggtgcc gcacaggcca cgaaaggagg agtgagcagg agactcagct
    13801 ctccggcgga gtgtccgcga ccacccacat cgagaagaac tgcgagccgc cgccataggc
    13861 gtgaccgagc gccttacggg cgccgtcgac ctggtgttcg cccgcccgcc cgcgcacctg
    13921 gagcgcggcc tcggcgaacc gcagcattcc ggacgccccg atcgggttgg tggacagcac
    13981 cccgccggac gggttgaccg ggagctcgcc gtcgatctcg gtcacccccg actcggtgag
    14041 cttccagccc gccccctcgt ccgcgaagcc caggttctcc agccacatcg gttcgtacca
    14101 gctgaagggc acatacatct ccaccgcgtc gatctcccgg cgcgggtcgg tgattccggc
    14161 ctggcggtag acatcggccg cgcagtcccg gccggcccgc ggcgagacga agtccttccc
    14221 cgcgaagagc gtcggctcgc tgcgcatggc gccgccgtgc atccaggcgg gcggatacgg
    14281 cgcgcggtcg gcgccggcgc ggtcggtgag caccatggcg caggcgccgt ccgaggaggg
    14341 gcaggtctcg gagtagcgga tggggtccca cagcatcggg gaggaccgca cccgctccag
    14401 ggtcagatcg tgctcgtgga ggtgggcgta ggggttgcgc agggcgttgc ggcggtcctt
    14461 gtaggccacg agcgcgccga taccgggggg cgcgccggtg cgccgcatat acgcccgtac
    14521 gtgtggtgcg aagaagccgc ccgccccggc cagcagcggc tgctggaagg ggatgggcag
    14581 ggaaagcccc cacatggcgt tcgactccga ttgcttctcg aaggcgaggg tgaggacggt
    14641 ccggtggacc cgggcggcga tcagccccga ggccaccagc gcggtggagc cgccgaccga
    14701 gccggcggtg tgcacgcgca gcatcggctt gccgacggcg ccgagcgcgt cggcgaggta
    14761 cagctcgggc atcatgacgc cctcgaagaa gtcgggggcc ttgccgatca cgacggcgtc
    14821 gatgtccgcc cagcccagct gggcgtcgtc cagggcccgt acggcggcct cccggaccag
    14881 cccggcgatg gagacgtccc ggcgtgcggc ggtgtgcttg gtctggccga tcccgacgac
    14941 ggccaccggc tccttcgtca cgtgtcatcc ccttccagga cggccaccag gttctgctgg
    15001 agacaagggc ccgaggtggc atgggcgagg gtccggtccg cggcgccgcg gtggatggcg
    15061 gcggcggcct cgccgaggcg gatcagcccg gcggccatca gcgggttggc ggccagcgcc
    15121 ccgccggacg gattgacccg tacgccctcc cccagccgca gctcacggcg gaggatcagc
    15181 tcctgtgagg tgaacggggc gtgcagctcg gccaggtcca cgggggcctc gaaggcgccc
    15241 gcgcgctcgg cggcgagccg ggtggacggg gagcgggtga ggtcccgtac gccgaggctg
    15301 tgggcctccg tccggtgatc gataccgcgg atccaggcgg ggcggcggca gagccggcgc
    15361 gcggtgtccc cggcggcgag cacgacggcg gccgcgccgt cgccgaccgg cgggcagtcg
    15421 tggcggcgca gcggccgcac cacatacggg tcctccagga gggcctcggg cggcggtgaa
    15481 ccggtcagct gggcatgcgg gttgccctcg gccgcggtcc ggctgcgcgc cgcgaccccg
    15541 gccagtgccc gctcgtcggc accggtgtcc tccgcgtcca gcagcgcctg ggcctggagg
    15601 gcggccaggg agaccgagtc cggccacagg ggcgccacgt agtacgggtc gagctggcgg
    15661 gtgaggacct cgcgcggatc gccgggtgag gacttgccgt aggagtagac gagcgcggtc
    15721 tccgcctcgc cggtcagcag cctcgtccat gcctcgtaca gcgcccaggc gccgtccatc
    15781 tccacatggg actccgagat gggcggccag gcgccgacgc cgtcgagggt catggtgaag
    15841 gagaaggcgc ggcccgccag atagtcgcag gagccggagc aggtgaagtc gatctcgccg
    15901 gcccggagtc cgacggcgtc gagcacctgg tggaggacgg gcatcaacat ctcgacctcg
    15961 gagatctccg cggtgtcgcg ccggtggtcg ctctggccga aggcgacgat ggcaacctct
    16021 cgcatctaca acagctcctt gtaggtgtcg tagtcggcgt cgggttcgcc ggtggggcgg
    16081 tagtggtcgg ggtagcggcc gtccccgctc catacgggct ccacgcgcag ccccatccgc
    16141 acctcgtcgt aggggatgtc gccgatgcgt gcgtggaggg ccagatcggc gccgtccagg
    16201 gcgatgtggg cgtagacgta cggcacttcg atatcgaggt tgcgggcctt gatgttgacg
    16261 atgcagaagg tggtgaccgt gccgcggggg ccgacctcca cctgttcgtc ggtggccaca
    16321 ccgcaggtgg ggcaggcgcc ccggggcggg acgtacacct tgcggcagga cgggcagcgc
    16381 tccccgtaga tggtgcggcc ggcgagggcc ttcagatagc gcgactgggc gcggccgggc
    16441 gcgtaggtgt agtcgaggcg ggcgggggcc acgatgccgt cgacggggtc ggtgaactcg
    16501 cccctgtgcg gcacggctcg gccgcccccg gcgccgtcgt acggctcgaa gcaggcgatg
    16561 tcggtgatgg cgccgacgcg ctccccggcc cagcggatcc gcacccccat accggtgcgc
    16621 accgcgtcgg ggccgggcgc gtcgagggcg tggaggagtg cggtgtccgc gccgtccagc
    16681 cgcaccagca cccaggcgaa gggggtgggc aggggctggc cgcggcgcgg ggaggggttc
    16741 caggcccagg tggtgacggt gccagtgggg gcgacttcga cgaggtcgga cagttcgtcg
    16801 gcggtgaccg ggtcgtattc gacgggcggc atcagcaccc ggccgtcggt ggtgcgcacg
    16861 ccgagcacgg tgcgttcgcg cagcccggtg aggaaggcgc tctgcaccgg gccgagggag
    16921 cgggtgaacg ggaactcgac gaccagaggc gcctggagcg cctcgggcga gggagccggg
    16981 gtcatggggg tgcgtctcct tccgcgcggc cgccgggtgg gggcgccggc ctgaggtggt
    17041 gggggatcac gcccggcggt agaccggcgg ccgtttctcc gcgaaggctt tcgagccctc
    17101 cttggcatcg gcggtgtcga agatgggcca gccgcgttcg agttcggact tcaggccgtc
    17161 ggtctcggtc atctcggcgg tctcgtagac ggacgccttg accgcctcga cggcgagcgg
    17221 gccattggcg ttgatcagct ccgcgatctc cagtgccttc tccagcgccg tgccgtccgg
    17281 gacgacatgg ccgatgagcc cgatccgcgc cgcctcctcg gccgggtagg ggcgccccgt
    17341 cagcagcatc tccagggcgt gggtgcgggg cagctggcgg gtcagccgta cggtggagcc
    17401 gccgatgggg aacagcccgc gccggacctc gaagagcccg aaggtggcgc cgcggcccgc
    17461 gacccggata tcggtgccct ggaggatctc ggtgccgccc gcgacgcagg ggccctcgac
    17521 ggcggcgatg accggcttgc gcggccggtg gtggcggagc atcgccttcc agtgcagatc
    17581 ggggtcggcc gcgaggcggt cgcggacatg ctcgccggcc atccggccgc cgcccgcgag
    17641 cgccttgagg tccattccgg cgcagaaggc cccaccggcg cccgtgagca ccacggagcg
    17701 cacggtgtcg tcctcgtcgg cctcggtcca gccgtcgtac agcccgacca gcatcggcag
    17761 cgagagcgcg ttcctggcct cgggccggtt caaggtgagc accagggtcg cgccgacgcg
    17821 ctcgacgatg aggtgttcgg tcccgcttgt cacgacgtcc tcccgtctcg agacctagaa
    17881 caggttgcag cagccgcagg ccgacttcaa gagaaatctg atgctcagtc agatttcttg
    17941 ttccgtgggc cttcccacct catcccggcg cggctctaat gagcgccgag ccgccggatc
    18001 gaggggtcag gaggagccgt ggagtacaac cttgccgacc tgttcgagtc gatcgtcgac
    18061 acggtgcccg acagagaggc gctggtgtac atcgaccacc ccggcaccgg ggccgagcgg
    18121 cgtctgagct acgcccagct cgacgcggcc gccaaccggc tcgcccacca tctcggtgac
    18181 agcgggatcg ccccgggcga gcacgtcgga ctgcatctgt gcaacggcgt cgagtacctc
    18241 cagaccgcgc tggcctgtct gaagatccgg gcggtgccgg tgaacgtcaa ctaccgctac
    18301 gtcgaagacg agttggtcta tctctaccgc gacgcggacc tggccgcgct ggtctacgac
    18361 gccgagttcg gcgagcgggt ggccgccgcg ctgccccaca ccggcaccct gcgccatctg
    18421 gtgcgggtcg gcaccgggca cggcccccgt gcgtccgtgg cgttcggcga cgccgaggcg
    18481 tccgggtcgc ccgagcgcgg cttcccggcg cgctccgccg acgaccgctt catcatctac
    18541 accggcggca ccaccggtat gcccaagggc gtggtgtggc ggcaggagga cctgttcttc
    18601 tcggggctcg gcggtggcgc cccgaccggc cggcccgtgg ggcgcccgga ggagctggcc
    18661 gagcgggtgg ccgcgggcgg cgaggggctg gccttcttcc ccaccccgcc gctgatgcac
    18721 ggcacctcca cccttacggc cttcatcgcg ttcaacttcg gtcagaaggt ggtgctgcac
    18781 cgaaagttca tgcccgagga ggtgctgcgg accatcgaga aggagaaggt caccgccgcc
    18841 tcactggtcg gcgacgcgat gctgcggccc ctggtggacg ccctgaccgg acccctccaa
    18901 ggcaccgatc tctcctcgct gctcagcgtc agcagctcgg gcgcgatcct gtcggagacc
    18961 gtacgcgccc agttcgccga gctcgccccg cacaccctgc tgctcaacaa cttcggctcc
    19021 tcggagtccg gtttcaacgg cacggccacc gccgactccg gtcccgagaa gggcttccgg
    19081 ctgcgcgtca acgcccgtac gacggtggtg gacccggcga ccctcacccc ggtggcgccc
    19141 ggtgagcccg gccggatcgc ccagcgcggc catgtgccgc tcggctacta caacgatccg
    19201 aagaagaccg ccgagacgtt cttcgagacg gacggggagc gctgggtgct gctcggcgac
    19261 atggcgaccg tggacgagga gggtgtgatc accgtcctcg ggcgcggttc gcagtgcatc
    19321 aacaccgggg gcgagaaggt ctacccggag gaggtcgagc aggccctgaa ggcccatccg
    19381 gaggtgtacg acgcgctggt ggcgggcgtc cccgacaccc gatggggcca tcgcgtggcg
    19441 gccgtcgtcc agccccggac cccggcgtcc gggctcaccg ccgacgcggt ccgcgaccac
    19501 tgccgtgagc ggctggcggg ctacaagatc cctcgtacgg tcgtcttcac cgaccacatc
    19561 cagcgctctc ccagcggcaa ggccgactac cgctgggcgc gggcggtcgc ccaggggacg
    19621 gacggggaga ccccgcacca ggaccgggac gccccgcacc aggaccgggg cgccccgcac
    19681 cccggctgac ccgccgcgcc gactaagcag atcggcggaa gtcggctgcg gttcggtggc
    19741 gccccgaaag ggcgcggggc tgtgtcgatg tgcggctccg ccgcgtgggc gcgaccagcc
    19801 acgacggcgc cgcggacgat cgacggcagg tcagggcact tccagcggag cgcttagggg
    19861 tccttgcact atgagcgccc gatgaggtcg cgtggtctgg tgccgtgcat cgcaaggcgc
    19921 cggagagccc tcgtagcgga gctactaggg cttttcggca acgcggcgag gtgcggtgcc
    19981 aggccgcgcg acccgggcgg gcatagtgca aggacccctt aggctgacca ggtgactctt
    20041 cctgccgcgg cggtgcccct tccctctgtg accctggccg acgggatcac catgcgaacc
    20101 gccgtcgagg acgacgccga ggcgctcgcg gacgcgtaca cgcgcaaccg tgagcatctg
    20161 cgcccctcca gcccgcggcg ggacgagagc ttcttcaccg ccgacggcca ggccgcccgg
    20221 ctgcgggacc agctggagca gtgggagtcc ggccggatgg tgccctgggt gctgaccggc
    20281 ggcgagcgga tcctgggtac ggtcacgctg tcgcatatcg tcctcgggcc ctggcgcaac
    20341 ggccatctcg gctactggat cgacgccggg cacctcgggc gcgggctggc ctccctggcc
    20401 gtccggtccg tgtgccgggt ggccgacgag cgcctcggac tgcaccggat cgaggccagc
    20461 acgctggtgg agaatgtccc gtcccaaggc gttctgctcc gctgcggatt cacccggatc
    20521 ggcatggcgc cggactatct gcacatcgcc ggcgcctggc gggaccatct gctcttccag
    20581 cgcgtcctcc acgaccgccc cgcagcctga cccgcccccc ttcacggctt gacggcgctc
    20641 agcgctcgca caccgacggc agcgagcggc cgagcgccac cgtgtgcagc acgtccaggt
    20701 ggcgcccgtg gaccacggcg accgtcccgg ccgtgagccg ccccacgcag gaggggccct
    20761 cgcgcacggc cgccgagtcc gcgatggcgc gtacgagttc gccgttgatc cggttgatct
    20821 ccagccggat ccgcccgagg tcggggcgtt cggtgggcgc ctgtgagggg tcggcgtccc
    20881 agcggtggta gaggccgcgc tggacgacct tgctggcctc gatctggtcg cggaagatcc
    20941 tcgtcgtcgc cgcggggtcg gcgcccaact cctcggcctg ccgtgccacc gcgtccagca
    21001 cctcccgctc ccgcgccgga tcgtcgatcg ggctgtccgt gccccacttc gcggcggcga
    21061 cctcgtcggc caccagcacc cgctgcgcgg ccagttcgac cagcggccgc agagtgccgt
    21121 gggcacgggc cggaccagcc ggacctgccg gtgcggcgac ggcggcggtg gccccggtgg
    21181 ccagcacg
//
