LOCUS       NZ_CP019458            23790 bp    DNA     linear   CON 05-MAR-2024
DEFINITION  Streptomyces autolyticus strain CGMCC0516 chromosome, complete
            genome.
ACCESSION   NZ_CP019458
VERSION     NZ_CP019458.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces autolyticus
  ORGANISM  Streptomyces autolyticus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10029028)
  AUTHORS   Yin,M., Jiang,M., Ren,Z., Dong,Y. and Lu,T.
  TITLE     The complete genome sequence of Streptomyces autolyticus CGMCC 0516,
            the producer of geldanamycin, autolytimycin, reblastatin and
            elaiophylin
  JOURNAL   J Biotechnol 252, 27-31 (2017)
   PUBMED   28472671
REFERENCE   2  (bases 1 to 10029028)
  AUTHORS   Yin,M., Jiang,M. and Lu,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JAN-2017) Yunnan University, Yunnan University, 2#
            Cuihu Beilu, Kunming, Yunnan 650091, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT Analysis v. 2.3.0
            Genome Coverage                   :: 279x
            Sequencing Technology             :: Illumina; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 03:05:38
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,227
            CDSs (total)                      :: 8,141
            Genes (coding)                    :: 7,920
            CDSs (with protein)               :: 7,920
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 221
            CDSs (without protein)            :: 221
            Pseudo Genes (ambiguous residues) :: 0 of 221
            Pseudo Genes (frameshifted)       :: 74 of 221
            Pseudo Genes (incomplete)         :: 182 of 221
            Pseudo Genes (internal stop)      :: 9 of 221
            Pseudo Genes (multiple problems)  :: 42 of 221
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:31:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1147218
            Orig. end                         :: 1171008
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP019458.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23790
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="7"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..23790
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23790
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:13790](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13790)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(105..1313)
                     /locus_tag="BV401_RS04800"
                     /old_locus_tag="BV401_04795"
     CDS             complement(105..1313)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058147.1"
                     /locus_tag="BV401_RS04800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_04795"
                     /product="MFS transporter"
                     /protein_id="WP_079256231.1"
                     /transl_table=11
                     /translation="MLGRYAMRCYLGGAAAARAGDEMSGPALLLAGPALTDSATSGSSL
                     LAGVMVAAALGGPLFGVLLDRSARPGRLLAAALALYAAALTAILLALERLPFALTVLLA
                     VGAGLLGPALSGGWTSQLPRVAPPGTLPRANALDAMTFSLAALVGPALAGAVAGALGAP
                     AAVAVSIALIGLALPAAWALPAPERPVSTPPPTSSVRADFTAGLRVVARNRRLARATAT
                     SVISCVGQGALLTCCPPLGAAVLGGADRGALLLSATAASALVANAALARHPRPPRPDTV
                     LLGGALLLVLAPLLAAIGHPAPVIAAALLTGAAEGPLLTALFAVRHREAPERLRGQVFT
                     TGASLKITGFALGAALAGPLAAWSLPGALVAAAGCAGLAALVFVCWSNGTEATAPLPPP
                     GAV"
     gene            1370..1945
                     /locus_tag="BV401_RS04805"
                     /old_locus_tag="BV401_04800"
     CDS             1370..1945
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018384910.1"
                     /locus_tag="BV401_RS04805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_04800"
                     /product="CGNR zinc finger domain-containing protein"
                     /protein_id="WP_193524941.1"
                     /transl_table=11
                     /translation="MSPPLNDDRSTRHSVRATARRTAALVNALTAEPDPDPGAIAGILL
                     DHGELGPLELTAGDVAGLRTAALRLREVFTADGVDEAAGVLNRLLREGTGPLRLSSHDG
                     RSPWHPHLDSDDEAPWGEWFLASSCMALTVLLWEGQRPPGGLCSSPGCGDVFLTVGSGP
                     EHRYCSRRCATRERVAAHRRARAGSRSP"
     gene            complement(1968..3557)
                     /locus_tag="BV401_RS04810"
                     /old_locus_tag="BV401_04805"
     CDS             complement(1968..3557)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058149.1"
                     /locus_tag="BV401_RS04810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_04805"
                     /product="cation acetate symporter"
                     /protein_id="WP_079256233.1"
                     /transl_table=11
                     /translation="MSFLDPRTLAFVLFAGFMAISFLLCILAATGNDDPTEFYLGTGAL
                     SPMQNGLAIAGDYISAATVLSTTGTIALAGFDGVLIATSTVLSILLFMLVLAGPLCGRG
                     QFTLGDVLSERLSERPARVGTAVVVLVVVLPLLLVQLNGAGDMLALLLGIPGSGAVTGC
                     TVFIGSLMVCYAALGGMKGTGFIQILKTVLLLAAFVLLACLVLRRFSWNPVTLFDAAAD
                     ASGYGNGFWQSGRQYGDSLSGRLDVISVQLTLAVGAACMPHLTMRLHPIRGMRAARAAT
                     TWAVGAVTTILGLIVIVGAGATAVVGARALRASDPTGGDSLLLLTLALDPAAPEAHRSL
                     LFSVVACAVVATTLAAVAGLTLAAAASLAHDVLAKVVFRGRLSADRELAAARAAIVAVG
                     VTAVVLAIVTQHWNRQVLISFTFAAAASALLPVVLYGTLWRGFTVNGLRWALYGGLVLT
                     AVAMAFSPAISGNPLAVFPDRDFHWFPLRNPGLITVPAGFLLGWFGSRIGRRARHAQDP
                     ARGDTPYATHPG"
     gene            complement(3554..3958)
                     /locus_tag="BV401_RS04815"
                     /old_locus_tag="BV401_04810"
     CDS             complement(3554..3958)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BV401_RS04815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BV401_04810"
                     /product="hypothetical protein"
                     /protein_id="WP_079256234.1"
                     /transl_table=11
                     /translation="MSDHDHLWGSPVPSVPPVGSRATHPTAHRGPYRTTRRAATMPHHA
                     TAPPSPPPPPERRSPWQRPWPWPARAACAALTCHVAAVVVNCAAEGVVNLGAGGGFTVG
                     AMLIGLDTAVLLTVLARAHRRSGAAGEGER"
     misc_feature    4065..4081
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 23.13"
                     /tool="antismash"
     gene            complement(4127..5479)
                     /locus_tag="BV401_RS04820"
                     /old_locus_tag="BV401_04815"
     CDS             complement(4127..5479)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058151.1"
                     /locus_tag="BV401_RS04820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_04815"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_193524942.1"
                     /transl_table=11
                     /translation="MHPVTGSRASAPAMGRPAPRRSADRGRTPPRMPAARPPIRSRADA
                     ETVALLHRTARVLIEEVPRLTDRIVTLMKEREPVYRSPSLDPHEVWREVHDSLSHNVRS
                     LVRPKETRESARSCAWRIGTDRAAQGFPLDALLHAYRIGCTVVWERLLETASKEDPLGA
                     QALVHVAADVWNFVDEHCTLVATAYQEVERQLSWHRENRYRIIVAALLDGTARVTDFPE
                     AEEVLGLPERGRYAVVALEDTDAPARPPHPVTGLCAGLRAVWNTAEGIAHAIVLLGDGD
                     GGDGYGGDGDGGDGAGVERLVRGLELPPGARAGVSPAVTGLAAVNTARRLADTALRTRP
                     AAGEAALLEERYPEALVVSSPDLGTALADRMLGPVLALEPADRELLLTTLAAWLEADGS
                     ARRAGELLFCHRNTVLNRLRRYEQLTGRSLDRPREVMELSLALSAHRLLTS"
     gene            5736..6179
                     /locus_tag="BV401_RS43070"
                     /old_locus_tag="BV401_04820"
     CDS             5736..6179
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024966.4"
                     /locus_tag="BV401_RS43070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_04820"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_069872234.1"
                     /transl_table=11
                     /translation="MLDRLAVHELIHRWWFVFDEGQFDVWPELLTEDVHITSRSDTGKS
                     PYEEFIASDNQGREQVIAWQRKHREAAGYPLRHNASNIHIERVDGDDISVVSYMYATNI
                     TEGQVTPIAGGVVRCVVRSDGAAYRLAQLHIVLDTHAVAFTER"
     gene            complement(6285..6734)
                     /locus_tag="BV401_RS04830"
                     /old_locus_tag="BV401_04825"
     CDS             complement(6285..6734)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058153.1"
                     /locus_tag="BV401_RS04830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_04825"
                     /product="spore-associated protein A"
                     /protein_id="WP_069872232.1"
                     /transl_table=11
                     /translation="MNLSRRMAATAVLATAAIAGTVAITPQASAAATATYNGVCGTGYK
                     VVNSAPIGSKGTVFLTYNSAKGKNCVVTVRNATGKPVPMFAYLYVQGADESAEDGGAYT
                     SYAGPVYGDGRGKCVDWAGGIENQSTWTYGSNCGSLTAHRVTKGW"
     gene            6930..7814
                     /locus_tag="BV401_RS04835"
                     /old_locus_tag="BV401_04830"
     CDS             6930..7814
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058154.1"
                     /locus_tag="BV401_RS04835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_04830"
                     /product="lytic polysaccharide monooxygenase"
                     /protein_id="WP_079256236.1"
                     /transl_table=11
                     /translation="MTSHRTAAVGALLGALPCLFTALAAQPAQAHGAPTDPVSRTFACS
                     PEGGAAARAAACRAARAANGPEAADWDNLRIAGVAGRDRERVPDGKLCSGGLEAYRGLD
                     LARADWPSTRLSAGAKLTLTYRSTIPHTGTFELYLTKEGYAPTRPLRWSDLEPKPFATA
                     KDPALVDDAYRIQATLPAGRTGRQLLYTIWRNISTPDTYYSCSDVMLSAAAGKGPKDAP
                     ERPATPSDGAAAPSVEVTAPPSRGDAPPSPATSATEADDGGTTTPVLLAGGASVLVLGA
                     GVAATVRRRRPGR"
     gene            complement(7822..8685)
                     /locus_tag="BV401_RS04840"
                     /old_locus_tag="BV401_04835"
     CDS             complement(7822..8685)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: TauD (7-250). E-value: 3.4e-61. Score:
                     199.3. Matches aSDomain:
                     nrpspksdomains_BV401_RS04840_TauD.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1121: dioxygenase, TauD/TfdA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058155.1"
                     /locus_tag="BV401_RS04840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_04835"
                     /product="TauD/TfdA family dioxygenase"
                     /protein_id="WP_079256237.1"
                     /sec_met_domain="TauD (E-value: 4.6e-59, bitscore: 199.3,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTPELAVTPVSGALGAEIRGVDLTELTDELFERIHELLLEHLVV
                     FFPDQEHLTPEAHIALGRRLGELEVHPFLPKADGHPEIVVLDADQGAKADEWHIDVTFQ
                     PNPPVASILHLQVCPASGGDTMWSNQYLVYETLSEPMRELLDGLTAVHVLNTPQTGEHS
                     AEHPVVRIHPETGRRSLYVTRMWTSHIPQLSRPESDALLQYLFEHSESPRFNCRYRWQP
                     GAVAMWDNRATQHLAVNDYSGPRRGQRVTVLGDHPTGDTPRWKEYRPAPDERYYPRHVT
                     ARRGYR"
     aSDomain        complement(7936..8664)
                     /aSDomain="TauD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BV401_RS04840_TauD.1"
                     /evalue="3.40E-61"
                     /label="BV401_RS04840_TauD.1"
                     /locus_tag="BV401_RS04840"
                     /protein_end="250"
                     /protein_start="7"
                     /score="199.3"
                     /tool="antismash"
                     /translation="VTPVSGALGAEIRGVDLTELTDELFERIHELLLEHLVVFFPDQEH
                     LTPEAHIALGRRLGELEVHPFLPKADGHPEIVVLDADQGAKADEWHIDVTFQPNPPVAS
                     ILHLQVCPASGGDTMWSNQYLVYETLSEPMRELLDGLTAVHVLNTPQTGEHSAEHPVVR
                     IHPETGRRSLYVTRMWTSHIPQLSRPESDALLQYLFEHSESPRFNCRYRWQPGAVAMWD
                     NRATQHLAVNDYSGPRRGQRV"
     gene            complement(8700..10004)
                     /locus_tag="BV401_RS04845"
                     /old_locus_tag="BV401_04840"
     CDS             complement(8700..10004)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058156.1"
                     /locus_tag="BV401_RS04845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_04840"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_079256238.1"
                     /transl_table=11
                     /translation="MSPDVLVCGAGVGGLAAARALGGLGLDVLVVDKQPRIRPIAKGEV
                     LQPGALRLLRSWGVEQRLDAQGAVRLGRLVVRDPRGTALMSLDYGQLPAPDQWLLAHDH
                     TTILTALAEGLGPRVELRRGVRAESPLRDDSGRITGLRLAEGGRVYEERAPLVVAADGI
                     SSRLRTWADIEAKRIDYPHRLVSFDIADAEAAARADDFSAYVTDRGLRLLYPLPGGRLR
                     LYLQAGPDELRGVTARGGLADWATRALSQVPALEPLTASLLAHLDTRQTLPVGRLLSPR
                     LAGHGLALVGEAAYAVHPMAAQGMNTAITSAGALAERLADRLERMGGMSAAAVDGALRD
                     YHERQLPLLAQAARTSGNAARMVTDLSWRGRILGRRAVRHTGANPRLLHTVTHNMSGLG
                     PRPLTPLDRLQQLGLVPDPRAHRVPAAPAGRPQSM"
     gene            complement(10001..11725)
                     /locus_tag="BV401_RS04850"
                     /old_locus_tag="BV401_04845"
     CDS             complement(10001..11725)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058157.1"
                     /locus_tag="BV401_RS04850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_04845"
                     /product="prenyltransferase/squalene oxidase
                     repeat-containing protein"
                     /protein_id="WP_079256239.1"
                     /sec_met_domain="T2TS (E-value: 4.8e-38, bitscore: 129.8,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPSALTESVGTAIVAGAEALLAHRRDDGAFVFGAHHASPLNTAG
                     ALTALHFADPEGSAETIERGVTWLCETQRDDGGWAMRSVPTEPLTTALAAAALQLVAPR
                     RAASAVRAARDRFEELGGSAAVPEPVMTALIRQFHTFAGLPHEGAQRRLPLELLLLPGL
                     SRRLLSLRLPIYAGQALAQSAHRRRGPVGRALDRLARPRALAILRDAYEREGATGGFST
                     DPWLTGLICLGLARSGQAPDLVRAAAGWLRSAARPDGSWDLMPLDVTWTNFATAALIEA
                     GRADDPQLIGTREMLHRHQQPEPFDALGCPAGYWGFSSPRSWPMALETAESSAILLRLP
                     GGAYDPHVRAGLAWLTATQDAAGSWSLAVRNTKPGGFGPCPQMTAKIVGALLDSGAGAD
                     DPRVAKAVRWLVGRQRPDGSFEAMWYRGGTPGTAAALEALTRAGRTEEHHRAAARARDW
                     LLRTRHPDGSWSTGEGTRPGTVEETAWALRGLLAAGPSPADPALAAAARWLVDAQRADG
                     GWNPAPVNEYIRGCARYADDGIAAGLALRALAHYRSATATTTTRTKDITGDGEGGRP"
     gene            complement(11759..12757)
                     /locus_tag="BV401_RS04855"
                     /old_locus_tag="BV401_04850"
     CDS             complement(11759..12757)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ubiA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058158.1"
                     /locus_tag="BV401_RS04855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_04850"
                     /product="UbiA family prenyltransferase"
                     /protein_id="WP_079256240.1"
                     /sec_met_domain="ubiA (E-value: 2.3e-19, bitscore: 68.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAPRTALLAHLQTWRPYTLWYPGLVGLAGASLTGSHPTTGQLTV
                     AWAAPTLGWVAGHYLGDYYDRDLDALSKPQRPIPSGRLSPRTAVAAGIGCALAVAALAL
                     WANWRAVAVAAAAMAGIVAYSRVLKGRGLPGNLVRGVLTALTVLFGAMAVQPWPPWRTL
                     PFALVFLAHDTASNLVGTLRDVDGDREGGYATVPVRRGVRRATHTAAALYLTAVAVACA
                     ATGLVPEDTAGYLVLLSAAALCGAGVFGLLLRSPGHLTPALALRAHAVLVCERLVLAAA
                     VVAAGAGAVPALALLTPLLAVSVITQSRMRSRHEFPAPLADGRPTLPDPRP"
     gene            complement(12762..13790)
                     /locus_tag="BV401_RS04860"
                     /old_locus_tag="BV401_04855"
     CDS             complement(12762..13790)
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058159.1"
                     /locus_tag="BV401_RS04860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_04855"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_079256241.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 3.8e-51, bitscore:
                     172.7, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPPDVAVTEVADPLAEAAPTMELLLRELDRRWPREAERLHRISR
                     YALLPAGKLLRPLLLMEAAEAVGGGGPAVVPAALSVEYLHVGSLVHDDVIDGDAMRRGR
                     PSVAARHGTADAIVTGDALMLGTFGVLTDGTDEAGGLPPGRVLDAVRVFAQAGVDLCRG
                     QAMEAELRGDLGCGLDRYVTMTALKTGALFRAACRGGAILGGGSPAQRHALTAYAEHLG
                     SAFQMHDDLLPYTSDSRTTGKSALSDIAAARPTFPVLLCHAMAGAPARARLEAALGGAL
                     PAADALRTVHELLETTGALDAARDRATAQADLAKSCLAELPRSRATAVLAAVADLSVSR
                     DR"
     gene            complement(13787..14806)
                     /locus_tag="BV401_RS04865"
                     /old_locus_tag="BV401_04860"
     CDS             complement(13787..14806)
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (19-319). E-value:
                     6.4e-44. Score: 142.4. Matches aSDomain:
                     nrpspksdomains_BV401_RS04865_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058160.1"
                     /locus_tag="BV401_RS04865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_04860"
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="WP_237287420.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 9.3e-42, bitscore:
                     142.4, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPVVAENNPFHQMSLNETVHPPLPEVVDAVLRTARNAHRTLDAL
                     GTRLCQALAAHLGVGPEHILAGPGSGALLQELFSTLTGPDTDTVHAWPSWEAYPMMAAN
                     AGSTTVRVPLSGYDHDLKAMADAVTDRTRMVLLCTPNNPTGTALDQERILRLLDRLPAH
                     VTVVIDEAYRDFADPGAIADGIALHRADERVCVVRTFSKSYGLLSLRVGYLVAHEPVLA
                     PLRSVLPFHRVSAVAQEAAIAALGAHERVLGQCARTVEERERLHRTLLDQGWEVPASQG
                     NFLWLPMTSGVERFTQFCADHGVVVCGKPGEGIRVTVAEPAANQAFAQLAGKYREATV"
     aSDomain        complement(13850..14749)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BV401_RS04865_Aminotran_1_2.1"
                     /evalue="6.40E-44"
                     /label="BV401_RS04865_Aminotran_1_2.1"
                     /locus_tag="BV401_RS04865"
                     /protein_end="319"
                     /protein_start="19"
                     /score="142.4"
                     /tool="antismash"
                     /translation="VHPPLPEVVDAVLRTARNAHRTLDALGTRLCQALAAHLGVGPEHI
                     LAGPGSGALLQELFSTLTGPDTDTVHAWPSWEAYPMMAANAGSTTVRVPLSGYDHDLKA
                     MADAVTDRTRMVLLCTPNNPTGTALDQERILRLLDRLPAHVTVVIDEAYRDFADPGAIA
                     DGIALHRADERVCVVRTFSKSYGLLSLRVGYLVAHEPVLAPLRSVLPFHRVSAVAQEAA
                     IAALGAHERVLGQCARTVEERERLHRTLLDQGWEVPASQGNFLWLPMTSGVERFTQFCA
                     DHGVVVCGKPGEGIRVTVA"
     misc_feature    14944..14959
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.77"
                     /tool="antismash"
     misc_feature    15075..15090
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.56"
                     /tool="antismash"
     misc_feature    15082..15097
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.69"
                     /tool="antismash"
     gene            15103..16026
                     /locus_tag="BV401_RS04870"
                     /old_locus_tag="BV401_04865"
     CDS             15103..16026
                     /GO_function="GO:0001216 - DNA-binding transcription
                     activator activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015431.4"
                     /locus_tag="BV401_RS04870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_04865"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_148666242.1"
                     /transl_table=11
                     /translation="MIDLRQLTVLTEVCRAGSYSAAADSLGYTQPAISYHMRALERAVG
                     VALTVKAGRGVRLTPAGHRLAERAQGVLAGLRDVENEFEALAARTRGRVRMSSVQSVSV
                     AVLPAALARLGASRIEVEVELGQTASQDAYRLLDSGETDLAIVADDEPGEAAGEATGPA
                     VTPLRRVPLLVDRRHVLLPRGHALAGRRSVHLADLSRERWILERDRERLLRRCAEAGFE
                     PRVVTTTDDQATTLGLVGDGVGIALMDGLGLLPRCDPRVEPRPLDGWPRRHVCALLRPE
                     AARVPAVAALLEALRAVAVEQSRDAA"
     gene            complement(16267..17274)
                     /locus_tag="BV401_RS04875"
                     /old_locus_tag="BV401_04870"
     CDS             complement(16267..17274)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (extras)
                     Sulfotransfer_3: Sulfotransferase domain"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060770.1"
                     /locus_tag="BV401_RS04875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_04870"
                     /product="sulfotransferase"
                     /protein_id="WP_079256244.1"
                     /transl_table=11
                     /translation="MSVRPLTFVVGTGRCGSTALSRVLRLHPDLLSVSELIASLEPDAL
                     PEAPLTGAQFWRILATPRSFANRVIRDGIPLPEYRYPHVEGRFSVSGGGIPALCMMTLP
                     HLTDDPDALFDALEPELTRRPAAPVADHYRALFGLLGERFGRRAVVERSGYSLRSVPRL
                     REVFPEARFVHLHRDGADCALSMSRHPGFRLIQLMTERAETTEDLPAGLDALLSDDDAD
                     LRPLYQRSVPTAEFGRLWSATIVEGLERLSRLPADIRMSLSYEGLLDAPERELTRLAHH
                     VGVEPLPEWLAAGRALLDGDRRGTAAATLPPAELAALRESCAPGARALSAVHGG"
     gene            17534..18445
                     /locus_tag="BV401_RS04880"
                     /old_locus_tag="BV401_04875"
     CDS             17534..18445
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018835145.1"
                     /locus_tag="BV401_RS04880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_04875"
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="WP_069872210.1"
                     /transl_table=11
                     /translation="MPAPVFSRRRGMRVAAAAAVALPLAAQPQYVATAVPAAPVAPADG
                     PRLAAMTFNLRYASDSEPNSWGRRRPVMRELLRRARPHLLGTQEGLYGQLRDIAQDLGQ
                     RYSWIGVGRMGGSRDEFMAVFYDTGRLEPLEYDHFWLSDTPNVIGSNTWGGAVVRMVTW
                     VRFHDRHTGKEFYALNTHLDHRGQNAREHAAALITERLGGLDSALPRIVTGDFNVAAHG
                     NPVYDAMLNGGTLVDTWDTAERRGPLYGTFHGFGPLTPDGDRIDWILTSPGVRTRHAAI
                     DTFSQDTQYPSDHLPVRTVLEL"
     gene            complement(18514..19713)
                     /locus_tag="BV401_RS04885"
                     /old_locus_tag="BV401_04880"
     CDS             complement(18514..19713)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1169: sugar
                     transport protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058164.1"
                     /locus_tag="BV401_RS04885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_04880"
                     /product="MFS transporter"
                     /protein_id="WP_079256245.1"
                     /transl_table=11
                     /translation="MESRRNDVSRAWPYLAAAYAFVVTMCGTTLPTPLYSLYQREFGFS
                     SFMVTVIFAVYAAGVIVALLLLGSVSDFIGRRPVMLAALVLSALSAVCFLLARGLPELF
                     AGRTLSGLSAGLATGTATVTVIELAPPSRRRAATLLATGANLGGLGVGPLLAGVLAQYA
                     PAPLKLVFVVDLVLVAVAAAVVLALPETVRTRSRPPLRPQRLRVPKEMRSTFAAAAMAG
                     FAGFATLGLFTSVSPTFLSEVEGESNLAVAGAVAFSVFAASIAGQVLGRRLGAGWSLPG
                     GCAVLVAGMAAIAVSLAIASLALLVLGAVVAGTGQGLSFHAAVRVVTERSPADRRAEVT
                     SALFVLMYLAISIPVIGVGALTVAVGLRTAGLVFTGCVALLAVATLLRVRALSAETADR
                     "
     misc_feature    19688..19703
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.19"
                     /tool="antismash"
     misc_feature    complement(19712..19728)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.58"
                     /tool="antismash"
     gene            20005..21066
                     /locus_tag="BV401_RS04890"
                     /old_locus_tag="BV401_04885"
     CDS             20005..21066
                     /GO_function="GO:0008381 - mechanosensitive monoatomic ion
                     channel activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058165.1"
                     /locus_tag="BV401_RS04890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_04885"
                     /product="mechanosensitive ion channel family protein"
                     /protein_id="WP_069872206.1"
                     /transl_table=11
                     /translation="MNRALTLHDVIVVGAALVCGAAGGVLLRLALRWLGERARATRWSG
                     DDIIVDTLRTLAPWASMAAGVAAAAAALPLTPTVGHDVDQTLVAALILVTTATAARVVA
                     DLVRSLALSRSGVAGTATIFVNITRIAVLAMGVLILLETLGVSIAPLLTALGVGGLAVA
                     LALQDTLANLFAGVHILASKTVQPGHYIRLSSGEEGYVVDINWRNTAVRQLSDNLVIIP
                     NAKLGNTIMTNFHQPEQQMSVMVQAKVGYGSDLDHVERVTVEVAGKVMSGVEGGVVDHE
                     ASVRFHTFGESGIDFSVFLRALEFSDQYLIKHEFMKELHRRFRAEGIEIPLPTRTLVLP
                     DQDRVPLPGRPAI"
     gene            complement(21072..21803)
                     /locus_tag="BV401_RS04895"
                     /old_locus_tag="BV401_04890"
     CDS             complement(21072..21803)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058166.1"
                     /locus_tag="BV401_RS04895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_04890"
                     /product="response regulator transcription factor"
                     /protein_id="WP_237287422.1"
                     /transl_table=11
                     /translation="MSPSPSPSSPSSSGPAAGPSPSLSSGPAPSVAPSAPAIRLLLCDD
                     HAVVRAGLRALLASTEGIEVVGEAGSGEEALAMATRLRPDVVLMDLQLGEGMDGVTATR
                     RLVRGDPPAPRVLVLTMFDTDADITRAIEAGATGYLLKAERPEELFAAIRNAASGRTAL
                     SAPVADRVLARMRSPRPGLSERERDILRQLARGLGNREIARALFISEATVKTHLGRIYG
                     KLGVETRAGAVAVATERRLLP"
     gene            complement(21800..23080)
                     /locus_tag="BV401_RS04900"
                     /old_locus_tag="BV401_04895"
     CDS             complement(21800..23080)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058167.1"
                     /locus_tag="BV401_RS04900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BV401_04895"
                     /product="sensor histidine kinase"
                     /protein_id="WP_079260286.1"
                     /transl_table=11
                     /translation="MLWSATWSAWSGRSGSDGPDDPDERWLTAVLHIAFFLLLGSSLVR
                     YLIRDTGGAPNGWVIALFVAFGALYPPGRWPAPASGPGGRPSGRYLVWLTAVLAAWVAL
                     LVLAPSAAWCAMPLFFTGLHTLPTRFAVPLAAVLTALVVASKLRFMHDGFDPNALIAPP
                     AIAAVAAAVLIHLRRQSARQRTLIDDLVRTRRDLAATERRAGILAERQRLSSEIHDTLA
                     QGLSSQRMLLQAADRTWETDPEAARGHMRDAAEIASRSLAEARRFVQDLAPADLAERSL
                     AQALGALAERESGPGRTVDFRLDGPLGPLPERVAAALLRIAQGALANVREHAGAGRAAL
                     TLTWMGDQICLDIADDGRGFDTGAVPAPGADRSRGHGLPAMRARVRQLGGTLTVESTPG
                     EGTVVSAAIPVEPLPALVPDRPVEATP"
ORIGIN
        1 cgcctcacgc cagtcggccg cccggacgtc gagccgtacg gcctcgaccg ggagcaggtc
       61 tttcagatct tccatgcagg tcatcatgga tgacatgggc accgtcacac agcccccggg
      121 ggcggaagcg gagcggtagc ctccgtgccg ttggaccagc atacgaagac gagggccgcg
      181 agccccgcgc accccgcggc ggccaccagg gcgccgggca gcgaccaggc ggcgagcgga
      241 ccggcgagcg ccgcgcccag ggcgaagccg gtgatcttca ggctggcgcc ggtggtgaag
      301 acctgaccgc gcagccgctc gggcgcctcc cggtggcgca ccgcgaacag ggccgtgagc
      361 agcgggcctt cggcggcgcc ggtgagcagc gcggcggcga tcaccggggc cggatggccg
      421 atggccgcca gcaggggcgc gaggacgagc agcagggcgc caccgaggag cacggtgtcc
      481 gggcgcggtg ggcgcgggtg gcgggcgagg gccgcgttgg ccacgagggc cgatgcggcg
      541 gtggcggaca gcagcagggc gccgcggtcg gcaccgccga gtacggccgc gccgagcggc
      601 gggcagcagg tgagcaacgc gccttggccc acacaggaga tgacggaggt ggcggtggcg
      661 cgggccaggc gccggttgcg ggcgacgacc cgcagcccgg cggtgaaatc ggcccggacc
      721 gaggaggtgg gcggcggcgt ggagacgggc cgctcaggcg cggggagcgc ccaggctgcg
      781 ggcagcgcga ggccgatcag cgcgatggac accgccacgg cggccggcgc cccgagcgcc
      841 cccgccacgg ccccggcgag tgcgggcccc accagcgcgg cgaggctgaa cgtcatcgcg
      901 tcgagcgcgt tggcacgggg cagggtcccc ggcggcgcca cccgtggcag ctgggaggtc
      961 cagccgccgg acagggccgg tccgagcagc cccgcgccca ccgcgagaag caccgtgagg
     1021 gcgaacggca gccgctccag ggccaggagg atcgcggtca gcgccgccgc gtagagggcg
     1081 agcgccgcgg ccagcagccg ccccggccgg gcggagcggt cgagcagcac cccgaagagc
     1141 ggcccgccga gcgccgccgc gaccatgacg cccgccagca gcgacgatcc ggaggtggcg
     1201 gaatcggtga gcgccggtcc ggccagcagc agcgcggggc cggacatctc gtcccccgcg
     1261 cgggcggcgg ccgcgccgcc cagatagcac ctcatcgcgt aacgccccaa catgcgcggc
     1321 acattacgca gctaacgcaa aacctcgcca ggtgcgttac attgaccccg tgtcaccacc
     1381 cttgaacgac gaccggtcca cccggcattc ggtacgggcc accgcccgcc gcaccgccgc
     1441 cctcgtcaac gccctgaccg cggagccgga tccggatccc ggcgcgatcg ccgggatcct
     1501 gctcgaccac ggcgagctcg gcccgctcga gctcaccgcc ggcgatgtcg cgggcctgcg
     1561 caccgccgcg ctgcggctgc gcgaggtgtt caccgccgac ggtgtcgacg aagccgccgg
     1621 ggtgctgaac cggctgctgc gggagggcac gggtccgctg cggctcagct cgcacgacgg
     1681 ccgctcgccc tggcatccgc atctggacag cgatgacgag gcgccctggg gcgaatggtt
     1741 cctggcctcg tcgtgcatgg cgctgaccgt gctgctctgg gagggtcagc gcccgcccgg
     1801 cggtctgtgc tcctcccccg gctgcggcga tgtcttcctc accgtgggca gcggaccgga
     1861 gcaccgctac tgttcgcgcc ggtgcgcgac ccgggagcgg gtggccgccc accggcgcgc
     1921 cagggccgga tcccggtccc cgtgaggact ccggcggatt cgacgcgtca gccggggtgc
     1981 gtcgcgtagg gcgtgtcgcc ccgggcgggg tcctgggcat gccgagcccg gcgtccgata
     2041 cgggagccga accagccgag cagaaacccg gcggggacgg tgatgaggcc ggggttgcgg
     2101 agcgggaacc agtggaagtc gcggtcgggg aagaccgcga gggggttgcc ggagatcgcc
     2161 ggggagaagg ccatggccac ggcggtgagc acgagccccc cgtacagcgc ccagcgcagt
     2221 ccgttcaccg tgaagccgcg ccacagggtg ccgtagagca cgaccggcag cagggccgag
     2281 gcggcggccg cgaaggtgaa ggagatcagg acctgccggt tccagtgctg ggtcacgatg
     2341 gcgaggacga cggccgtgac gccgacggcc acgatggccg cacgggcggc ggcgagctcg
     2401 cggtcggccg agagcctgcc cctgaagacg accttggcca gcacgtcatg ggcgagggag
     2461 gccgcggcgg ccagggtgag tccggcgacc gccgcgaggg tggtggcgac gaccgcgcag
     2521 gccacgacgg agaagagcag gctgcggtgg gcctccggcg ccgccgggtc cagggcgagg
     2581 gtgagcagca gcagggagtc gccgccggtg gggtcggagg cgcgcagggc gcgggcgccc
     2641 acgacggcgg tggctccggc acccacgatc acgatcagcc cgaggatggt ggtgaccgcg
     2701 ccgaccgccc aggtggtggc ggcgcgggcg gcccgcatcc cgcggatcgg gtgcagccgc
     2761 atggtgagat ggggcataca ggccgcgccc acggcgaggg tgagctggac gctgatgacg
     2821 tccaggcggc cgctgaggga gtctccgtac tggcggccgg actgccagaa gccgttgccg
     2881 tagccgctgg cgtcggccgc ggcgtcgaag agggtgaccg ggttccagga gaagcgcctc
     2941 agcaccaggc aggcgagcag gacgaacgcg gcgagcagca gcaccgtctt gaggatctgg
     3001 atgaatccgg tgcccttcat cccgccgagg gcggcgtagc agaccatgag cgagccgatg
     3061 aagacggtgc agccggtgac cgcgccgctt ccggggatgc cgagcagcag cgccagcatg
     3121 tcgcctgcgc cgttgagctg caccagcagc agcggcagga ccaccaccag caccacgacg
     3181 gcggtgccta cgcgggcggg gcgctcgctc agccgctcgg agaggacgtc gccgagggtg
     3241 aactgcccgc gtccgcacag cggtccggcg aggaccagca tgaacagcag gatggagagc
     3301 acggtggagg tggcgatgag caccccgtcg aatccggcga gggcgatggt gccggtggtg
     3361 ctgagcacgg tggcggcgga gatgtagtca cccgcgatgg ccaggccgtt ctgcatcggg
     3421 ctgagcgcgc cggtgccgag gtagaactcg gtggggtcgt cattgccggt ggccgcgagg
     3481 atgcagagca ggaacgagat ggccatgaag cccgcgaaga gcacgaacgc cagcgttctg
     3541 gggtccagga agctcaccgc tccccctccc ccgcggcgcc ggaccggcgg tgggcccggg
     3601 ccaggacggt gagcagcacc gccgtgtcca ggccgatcag catggcgccc acggtgaacc
     3661 cgccgcccgc gccgaggttg accacgccct cggcggcgca gttcaccacc accgcggcca
     3721 catgacaggt gagcgcggcg caggccgccc gcgccggcca gggccacggc cgctgccacg
     3781 gcgagcgccg ctccggcgga ggcggaggcg aaggcggcgc cgtggcgtgg tgcggcatcg
     3841 tggcggcacg gcgcgtggtg cggtacgggc cgcggtgcgc ggtggggtgc gtggcgcggg
     3901 acccgacggg cgggacggac gggacgggcg aaccccagag gtggtcgtgg tcggacatgt
     3961 cgcggctcct tgtgcggatt ccgtcccacg tcaccgggac ggaatcgcca cgacagcagg
     4021 tcggcacggt ggcgtacagg ccaaccggcg gaccgtgtga cgggcgcaca tgatcggcgc
     4081 ggggccgttg tgcacgccca caccgtctcg ggcgggcagc cagtgctcag gaggtcagca
     4141 gccggtgcgc ggacagcgcg agcgacagct ccatcacctc tcgggggcgg tccagtgaac
     4201 gcccggtcaa ctgctcgtag cggcgcagcc ggttgagcac cgtgttgcgg tggcagaaca
     4261 gcagctcgcc cgcgcgtcgc gccgacccat cggcctccag ccaggcggcc agcgtcgtca
     4321 gcagcagctc ccggtcggcg ggctccagcg ccaggaccgg tccgagcatc cggtcggcga
     4381 gcgcggtgcc gaggtccggg gaggacacca ccagcgcctc cggatagcgc tcctccagca
     4441 gcgccgcctc cccggcggcc gggcgggtgc gcagcgccgt atcggcgagc ctgcgggcgg
     4501 tgttgaccgc ggccagaccg gtcacggcgg ggctgacccc ggcccgtgcg ccgggcggca
     4561 gctccagccc gcgcaccagc cgctccacgc cggcgccatc accgccgtca ccgtcgccgc
     4621 cgtagccatc accgccgtcg ccgtcgccga gcagcacgat ggcgtgggcg atgccctccg
     4681 ccgtgttcca gaccgcgcga agaccggcgc acagcccggt gacggggtgc ggcggccgcg
     4741 ccggggcatc ggtgtcctcc agcgccacga ccgcgtaacg cccccgctcg ggcaggccga
     4801 ggacctcctc cgcctcgggg aagtcggtca cccgggcggt gccgtcgagc agagcggcga
     4861 cgatgatccg gtagcggttc tcccggtgcc aggagagctg ccgttcgacc tcctggtacg
     4921 ccgtggcgac gagggtgcag tgctcgtcga cgaagttcca tacgtcggcg gcgacatgga
     4981 ccagcgcctg ggcgcccagc gggtcctcct tcgaggcggt ctccaggagc cgctcccaga
     5041 cgacggtgca gccgatgcgg tacgcgtgca gcagcgcgtc cagcggaaag ccctgggcgg
     5101 cgcggtcggt gccgatccgc cacgcgcagg atctggccga ttcgcgcgtc tccttggggc
     5161 gcaccagcga gcgcacattg tggctgagcg agtcgtggac ctcccgccac acctcgtgcg
     5221 ggtcgaggga gggcgaccgg tagacgggct cgcgctcctt catcagcgtg acgatacggt
     5281 ccgtcagccg tgggacctcc tcgatgagca cgcgggcggt gcggtgcagc agcgccacgg
     5341 tctcggcgtc ggcccgcgac cggatcggcg gccgggcggc gggcatccgg ggcggtgtac
     5401 ggccccggtc ggcggaccgg cggggggccg ggcggcccat ggcgggggcg gaagcgcggg
     5461 agccggtgac ggggtgcata gacgttcctc cacctgtgac tggcgaaagc gcagctcgac
     5521 gcggcagcgt gaggccacgg ccaggtttga taccagagcc tgccccgcta ttgcaccatc
     5581 ggcataccga tgggtcggtg gcttcacgga attcttccgc acgcccggcg ggggccgcac
     5641 cggactccgg cggcggttcg gcatccggga cctcgtcggc cgacaccccc gggatatgct
     5701 gtcgatcact tgaatcctcg gggggagagc tccgtatgct cgatcgtctg gcggtccatg
     5761 agctgatcca ccgctggtgg ttcgtcttcg acgaggggca gttcgacgtc tggcccgagc
     5821 tgctgaccga ggacgtacac atcacctccc gctcggacac cgggaagtcc ccgtacgagg
     5881 agttcatcgc ctccgacaac cagggccgtg agcaggtgat cgcctggcag cggaagcacc
     5941 gcgaggcggc cggctacccg ctgcgccaca acgcctcgaa catccacatc gagcgggtcg
     6001 acggcgatga catctcggtg gtgtcctata tgtacgccac caacatcacc gagggccagg
     6061 tgaccccgat agccgggggc gtggtgcgct gtgtggtccg ctccgacggt gccgcctacc
     6121 gtctcgcaca gctccacatc gtgctggaca cccacgcggt ggccttcacc gagcgctagt
     6181 acccgtacga cgagtgcggc ggccacctca cagagatggc cgccgctccc ccgtgcgttc
     6241 ccccgtcggt gggctcgatc ggcgcgcggc ttccgggctt gcgcctacca gcccttggtc
     6301 acgcggtggg ccgtcaggga tccgcagttc gatccgtagg tccaggtgga ctggttctcg
     6361 atgcccccgg cccagtccac acacttgcca cgcccgtcgc cgtacaccgg gcccgcgtac
     6421 gaggtgtacg cgccgccgtc ctcggccgac tcgtcggctc cctgaacgta caggtaggcg
     6481 aacatgggaa ccggcttgcc cgtggcgttc cggacggtga ccacgcagtt cttgcccttg
     6541 gcggagttgt aggtgaggaa gacggtgccc ttggagccga tgggcgccga gttcaccacc
     6601 ttgtatccgg tgccgcacac cccgttgtac gtggccgtgg cggcggccga cgcctgcggc
     6661 gtgatggcca cggtgcccgc gatggcggcg gtggcgagga ccgcggtggc ggccatacgg
     6721 cgagaaagat tcatttgtcc cccttaatga ttcttcatgg gcgtaggcgc tgtttgcgtc
     6781 tgcctaggga gacatgcgga gctcgtggat ggttgtacgg cgtcatgcca cggcttccgg
     6841 gggcccgttg aacgcacggg ccggacctcc cgtatccccc gggacgggcg agccacccgt
     6901 cgccgcaccg agctggaggg ccgcaccgga tgacctcgca ccgcaccgcc gccgtgggcg
     6961 ctcttctcgg cgccctcccc tgcctgttca cggcgctggc cgctcagccc gcccaggcgc
     7021 acggggcgcc gacggatccg gtgagccgga cgttcgcctg ctcacccgag ggcggggccg
     7081 cggcgcgggc ggccgcgtgc cgggcggccc gggccgccaa tggcccggag gcggcggact
     7141 gggacaatct gcggatcgcc ggggtcgcgg gcagggaccg ggagcgggtc ccggacggaa
     7201 agctgtgcag tgggggcctg gaggcgtacc gggggctgga cctggcgcgc gccgactggc
     7261 cctcgacccg gctttcggcc ggggcgaagc tcacgctcac ctaccggtcg acgatcccgc
     7321 acacggggac cttcgagctg tatctcacca aggagggcta cgctcccacc cggccgctga
     7381 ggtggtcgga tctggagccg aagccgttcg ccacggccaa ggaccccgcg ctggtggacg
     7441 acgcgtaccg catccaggcc acgctgcccg ccggccggac cggccgtcag ctgctctaca
     7501 cgatctggcg gaacatcagc accccggaca cctactactc ctgctccgat gtgatgctga
     7561 gcgccgccgc ggggaagggc ccgaaggacg cgccggagcg gcccgccacc ccgtccgacg
     7621 gggccgcggc cccgtcggtg gaggtcaccg ccccgccgtc ccggggcgac gcgccgccct
     7681 ccccggccac ctccgccacc gaagcggacg acggcggcac caccactccg gtgctgctcg
     7741 ccggtggcgc gtccgtgctg gtgctgggcg cgggggtcgc cgccaccgta cggcggcggc
     7801 gcccgggccg ctgacgggct gtcaccggta gccgcgccgg gccgtgacat ggcgcgggta
     7861 gtagcgctcg tcgggcgcgg gccggtactc cttccagcgg ggggtgtcgc cggtggggtg
     7921 gtcgccgagg acggtcaccc gctgtcccct gcggggcccg ctgtagtcgt tgacggccag
     7981 gtgctgggtg gcgcggttgt cccacatcgc gaccgcgccg ggctgccagc ggtagcggca
     8041 gttgaaccgg ggcgattcgg agtgctcgaa gaggtactgg agcagggcgt cgctctccgg
     8101 gcggctgagc tgcgggatgt gcgaggtcca catgcgcgtc acatacagcg agcgcctgcc
     8161 ggtctcgggg tggatccgca ccaccgggtg ttcggcggag tgctcgccgg tctgcggtgt
     8221 gttgaggacg tggacggcgg tgagcccgtc gaggagttcg cgcatcggct cggagagcgt
     8281 ctcgtagacc aggtactggt tgctccacat ggtgtcgccg ccggaggcgg gacacacctg
     8341 gagatggagg atggaggcga ccggcggatt gggctggaag gtcacgtcga tatgccactc
     8401 gtcggccttg gcgccctggt ccgcgtccag gacgacgatc tcggggtggc cgtcggcctt
     8461 cggcaggaac ggatggacct ccagctcccc cagccgccgc cccagggcga tatgcgcctc
     8521 gggagtgagg tgttcctggt ccgggaagaa gaccacgagg tgctcgagca gcaactcatg
     8581 gatgcgctcg aagagttcgt cggtgagctc ggtcagatcg acaccgcgga tctccgcgcc
     8641 gagcgctccg gagacggggg tcacggccag ttcgggagtg ggcatgcgat aaaccgtcct
     8701 cacatggatt gcggtcggcc ggccggtgcg gccggcactc ggtgggcgcg cggatcgggg
     8761 acgagaccga gctgctgaag ccggtccagc ggggtcagcg ggcgggggcc gaggcccgac
     8821 atgttgtggg tgacggtgtg cagcagccgg gggttggccc cggtgtggcg gacggcccgg
     8881 cggcccagga tccggccgcg ccacgacaga tcggtgacca tccgcgccgc gttgccgctg
     8941 gtcctggccg cctgggcgag aaggggcagc tgccgttcgt ggtagtcgcg cagcgcgccg
     9001 tccaccgccg cggccgacat cccgcccatc cgctccagcc ggtccgccaa ccgctcggcg
     9061 agggcgccgg cgctggtgat ggcggtgttc atgccctgcg cggccatcgg gtggacggcg
     9121 tacgcggcct cgccgaccag cgccagtcca tgcccggcca gccggggcga cagcagccgt
     9181 ccgacgggca gcgtctgccg ggtgtcgaga tgggcgagca gggaggcggt cagcggctcc
     9241 agggcgggca cctgggacag cgcccgggtg gcccagtcgg ccagcccccc gcgcgccgtg
     9301 acgccgcgca gctcatcggg cccggcctgg aggtagagcc gcagccggcc gcccggcagc
     9361 ggatagagca ggcgcagccc ccggtcggtg acgtacgcgg agaagtcgtc ggcccgcgcg
     9421 gcggcttcgg cgtcggcgat gtcgaaggag accagccggt gcgggtagtc gatccgtttg
     9481 gcctcgatgt ccgcccaggt ccgcagccgt gaggagatgc cgtcggcggc gaccacgagc
     9541 ggggcccgct cctcgtagac cctgccgcct tcggccagcc gcagtccggt gatccggccg
     9601 gagtcgtcgc gcagcggcga ctccgcgcgg acgccccggc gcagttcgac gcgcggcccg
     9661 agcccctcgg ccagggcggt gaggatggtg gtgtggtcat gggccagcaa ccactggtcg
     9721 ggggcgggca gttgaccgta gtcgagggac atcagcgcgg tgccccgcgg atcgcggacg
     9781 accagccgtc cgagccggac cgcgccctgg gcgtcgagcc gctgctccac gccccaggag
     9841 cgcagcagac gcagcgcgcc cggctggagc acctctccct tggcgatcgg gcggatcctc
     9901 ggctgtttgt cgaccaccag gacgtccagt ccgaggccgc cgagcgcgcg ggccgccgcg
     9961 aggccgccga cgcccgcccc gcacaccagc acatcggggc tcatggcctg cctccttcgc
    10021 cgtcgcctgt gatgtctttc gtgcgggtcg tggtggtggc cgtcgcggag cggtagtggg
    10081 ccagggcccg cagcgccagg cccgccgcga tgccgtcgtc ggcgtagcgg gcacagccgc
    10141 ggatgtactc gttgaccggc gccgggttcc agccgccgtc cgcccgctgg gcgtcgacga
    10201 gccagcgggc cgccgccgcg agggccgggt cggcggggct cggcccggcg gcgagcagcc
    10261 cgcgcagtgc ccaggcggtc tcctccacgg tgccgggccg ggtgccctcg ccggtgctcc
    10321 acgagccgtc ggggtgccgg gtgcgcagca gccagtccct ggcccgggcc gccgcccggt
    10381 ggtgctcctc ggtgcggccc gcccgggtga gcgcctccag cgcggcggcg gtgccggggg
    10441 tgccgccgcg gtaccacatg gcctcgaacg atccgtccgg gcgctgccgg ccgaccagcc
    10501 accgcaccgc cttggccacg cgcgggtcgt cggccccggc cccggagtcg agcagggcgc
    10561 ccacgatctt ggcggtcatc tgggggcagg gtccgaagcc gcccggtttg gtgttccgca
    10621 cggcgagact ccaggacccg gccgcgtcct gggtggcggt cagccacgcc agtccggcac
    10681 gcacatgcgg gtcgtacgcg ccgccgggca gccgcagcag gatggcgctg gactcggccg
    10741 tctccagggc catcggccag ctgcgggggc tggagaaccc ccagtagccg gccgggcagc
    10801 cgagcgcgtc gaacggctcg ggctgctggt ggcggtggag catctcgcgg gtgccgatca
    10861 gctgggggtc gtcggcgcga ccggcttcga tcagcgcggc ggtggcgaag ttcgtccagg
    10921 tcacatcgag cggcatcaga tcccaggagc cgtcggggcg cgccgccgag cggagccagc
    10981 cggcggcggc gcggaccagg tcgggcgcct gtccggagcg ggcgaggccc aggcagatga
    11041 gtccggtgag ccaggggtcg gtgctgaacc cgccggtggc gccctcgcgt tcgtacgcgt
    11101 cacggaggat cgccagggcc ctggggcggg ccagccggtc cagggcgcgg ccgaccgggc
    11161 cgcggcggcg gtgggcggac tgggcgagcg cctggccggc gtagatgggc agccgcaggc
    11221 tgagcagacg gcggctgagg ccggggagga gcagcagttc cagggggagc cggcgctggg
    11281 cgccctcatg gggcagcccg gcgaaggtgt ggaactggcg gatgagggcg gtcatcacgg
    11341 gttccgggac ggccgcggag ccgccgagct cctcgaaccg gtcccgtgcg gcgcgtacgg
    11401 ccgacgccgc ccggcggggg gccaccagtt ggagcgcggc ggcggcgagc gcggtggtga
    11461 ggggttcggt gggcaccgag cgcatggccc agccgccgtc gtcccgctgg gtctcgcaca
    11521 gccaggtgac accgcgctcg atggtctcgg ccgagccctc cggatcggcg aagtgcagtg
    11581 cggtgagggc tccggcggtg ttcagcggcg aggcgtggtg cgcgccgaag acgaaggcgc
    11641 cgtcgtcgcg ccgatgggcc aggagcgcct cggcaccggc gacgatggcc gtgccgacgc
    11701 tctcggtcaa ggcggaaggg ggcatgggat cggacccttc tggtggtggc gcgccgtgtc
    11761 agggacgtgg atcggggagg gtgggccggc catcggccag aggggcgggg aactcatggc
    11821 gggaccgcat ccggctctgg gtgatgacgc tgaccgcgag gagcggtgtc agcagcgcca
    11881 gggcgggtac ggcgccggcg cccgcggcca ccaccgccgc ggccagcacc aggcgttcgc
    11941 agacgaggac ggcgtgggcg cgcagcgcca gcgcgggggt gaggtgcccc ggtgaccgca
    12001 gcagcaggcc gaagacgccc gcgccgcaca gcgccgccgc cgacagcagc accagatagc
    12061 cggccgtgtc ctcggggacc agcccggtgg cggcgcaggc cacggccacg gcggtcagat
    12121 acagcgcggc cgcggtgtgc gtggcgcgcc gtacgccccg gcgcaccggc acggtggcgt
    12181 agccgccctc gcggtcgccg tcgacgtcgc ggagggtgcc gacgaggttg gacgcggtgt
    12241 catgggccag gaagaccagg gcgaagggca gcgtccgcca cggtggccac ggctggacgg
    12301 ccatcgcgcc gaacagcacg gtgagcgcgg tcagcacacc gcggacgaga ttgcccggca
    12361 ggccacgccc cttgaggacc cggctgtagg ccacgatgcc cgccatggcg gcggcggcca
    12421 cggccaccgc gcgccagttg gcccacaggg ccagcgcggc caccgcgagg gcgcagccga
    12481 tacccgcggc cacggccgta cgagggctca accgtcccga cggtatgggg cgttggggct
    12541 tgctgagggc gtccaggtca cggtcgtagt agtcgccgag atagtggccg gcgacccagc
    12601 cgagggtcgg cgcggcccag gccaccgtca actgccccgt ggtggggtgc gatccggtga
    12661 gcgaggctcc ggcgagtccg accagaccgg ggtaccacag ggtgtacggg cgccaggtct
    12721 ggagatgggc gaggagtgcc gtgcgcgggg ccgccacggc gtcaccggtc ccggctgacc
    12781 gacagatcgg ccaccgccgc gagcacggcg gtggcccggg agcggggcag ttccgccaga
    12841 caggacttgg ccaggtccgc ctgggccgtg gcccggtccc gcgcggcgtc gagcgcgccg
    12901 gtcgtctcca gcagttcgtg caccgtccgc agcgcgtcgg cggcgggcag ggcgccgccg
    12961 agcgccgcct ccagccgggc gcgggccggg gcaccggcca tggcgtggca gagcagaacg
    13021 gggaaggtgg gccgggcggc cgcgatgtcg ctgagggcgg acttgccggt ggtgcggctg
    13081 tcgctggtgt acggcagcag gtcgtcgtgc atctggaagg ccgaccccag gtgttcggcg
    13141 taggcggtga gcgcgtgccg ctgggcgggg gatccgccgc ccaggatcgc cccgccccgg
    13201 caggcggccc ggaacagcgc cccggtcttc agggcggtca tggtgacgta ccggtcgagt
    13261 ccgcagccga ggtcgccgcg gagttcggcc tccatcgcct ggccgcggca cagatcgaca
    13321 cccgcctggg cgaagacccg tacggcgtcg aggacccggc ccggcggcag cccgcccgcc
    13381 tcgtcggtgc cgtcggtgag cacgccgaac gtgcccagca tcagggcgtc cccggtgacg
    13441 atggcgtcgg cggtgccgtg gcgcgccgcg acggacggac gtccccgccg catggcgtcg
    13501 ccgtcgatga catcgtcgtg gacgagggat cccacatgga ggtactccac gctcagcgcg
    13561 gccgggacga cggcgggtcc gccgccgccc accgcctcgg ccgcctccat gagcagcagc
    13621 gggcggagca gcttgcccgc cgggagcagg gcgtaccggg agatccggtg gagccgttcg
    13681 gcctcgcgcg gccagcgccg gtcgagctcg cgcagcagga gctccatggt gggggcggcc
    13741 tccgccagcg ggtcggccac ctcggtgacc gcgacatcgg gcggggtcat acggtcgcct
    13801 cccggtactt tccggcgagt tgggcgaacg cctggttggc ggcgggctcg gcgacggtga
    13861 cccggatgcc ttcgcccggt ttgccgcaca ccaccacgcc gtggtccgcg cagaactggg
    13921 tgaagcgctc cacaccggag gtcatgggca gccagaggaa gttgccctgg ctcgcgggca
    13981 cctcccagcc ctggtcgagc agggtccggt ggagccgctc gcgctcctcg acggtccggg
    14041 cgcactgccc gagcacccgc tcatgggcgc cgagcgcggc gatggcggcc tcctgtgcca
    14101 cggcgctcac ccggtggaag ggcaggaccg agcggagcgg ggcgagcacg ggctcatggg
    14161 ccacgagata gccgacccgc aggctgagca gtccgtagga cttggagaac gtccgcacca
    14221 cacagacccg ttcatcggcg cggtgcagtg cgatgccgtc ggcgatggcg ccggggtcgg
    14281 cgaagtcccg gtacgcctcg tcgatgacga cggtgacatg ggccggcagc cggtccagca
    14341 ggcgcaggat ccgctcctgg tccagcgcgg tgccggtggg gttgttgggg gtgcacaaca
    14401 ggaccatgcg ggtgcggtcg gtgacggcgt ccgccatcgc cttcagatcg tggtcgtatc
    14461 cggagagcgg cacccgcacg gtggtggatc cggcgttggc cgccatcatg gggtacgcct
    14521 cccatgaggg ccaggcgtgc accgtgtcgg tgtcgggtcc ggtgagggtg gagaacagct
    14581 cctggagcag cgcgccggag cccggtccgg cgagtatgtg ctccgggccc actcccagat
    14641 gcgcggcgag ggcctgacac agcctggtgc cgagggcatc gagggtacgg tgggcgttcc
    14701 gcgcggtgcg caggacggcg tccaccactt cggggagcgg ggggtgaacg gtttcgttga
    14761 gcgacatctg gtggaaggga ttgttctccg ccaccaccgg agtcatgcga ttccagccat
    14821 catgcatcgg gcaccatcca tccattccag cggggggtcg ggcggaggga ggaatgtcac
    14881 cgcgcccggt tccccttgcc ggtccggccg gatcgtcggg aaggaaaccg ttgtgggcgg
    14941 gctgtgaccg tacggtcagc cagtgcgggt gggaccgtgt ccgatcggtc agttcgatga
    15001 gcgagttcgg gcgaaatccg tcaccatgat tttgacggtc tcccgatcac tcgtccaatt
    15061 aaagtcttcc gggaattgat aaacgatttt tatcttcctg tagtgatcga tcttcgccag
    15121 ctcaccgtgc tcacagaagt ctgtcgcgcc ggctcctaca gcgccgcggc ggacagtctc
    15181 gggtacaccc aaccggccat cagctatcac atgcgcgcgc tggaacgtgc cgtgggcgtg
    15241 gcactcacgg tcaaggcggg acggggggtg cggctgacgc cggcgggtca cagactcgcc
    15301 gagcgcgccc agggggtgct ggccgggctg cgggacgtgg agaacgagtt cgaggcgctc
    15361 gccgcgcgca cccggggccg ggtgcggatg tcctccgtgc agagcgtcag tgtcgccgtg
    15421 ctgcccgccg cgctggccag gctgggcgcc tcccgtatcg aggtggaggt ggagctgggc
    15481 cagaccgcct cccaggacgc gtaccggctg ctggactcgg gcgagaccga tctggcgatc
    15541 gtcgccgacg acgagccggg agaggcggcg ggagaggcga cggggcccgc ggtcaccccg
    15601 ctgcgccggg tcccgctgct ggtcgaccgc cgccatgtgc tgctgccgcg cggccatgcg
    15661 ctcgcggggc gacgcagcgt ccacctcgcc gatctgtcgc gggagcggtg gatcctggag
    15721 cgggaccgcg agcggctgct gcggcgctgc gcggaggcgg ggttcgagcc ccgggtggtg
    15781 accacgaccg acgaccaggc gacgacgctg ggcctggtgg gcgatggggt gggcatcgcc
    15841 ctgatggacg gcctgggtct gctcccccgg tgcgatcctc gggtcgagcc gcgtccgctg
    15901 gacggctggc cccggcgcca tgtctgcgcg ctgctgcggc cggaggcggc cagggtgccc
    15961 gcggtggccg ccctgctgga ggcgctgcgg gcggtggccg tcgagcagtc gcgggatgcc
    16021 gcctgagcgg cgacggcccg acgccgggct acctcatcgg ccccgggccg ggctcagccg
    16081 ccacgcacgg cgcacgccga agacggtctc cggcgtgcgc cgggcgtctg ggccgggctc
    16141 atccgccgtg cgctcggctc agggcccgtt cggtccgccg tgcgctcggc ccaaggaccg
    16201 ccccctccga cgtgcacccg gctcaagacc cgctctgtcc gccgtgcgcc gggcccgggg
    16261 cccgtctcat ccgccgtgga cggcgctcag tgcccgcgcg ccgggggcgc agctttcgcg
    16321 gagggcggcc agttcggcgg gcggcagggt cgcggcggcc gtgccccggc ggtcgccgtc
    16381 gagcagggcc cgtccggccg ccagccactc cgggaggggt tccaccccga cgtggtgggc
    16441 cagccgggtg agctcgcgct cgggcgcgtc gaggaggccc tcgtacgaca gggacatccg
    16501 gatgtcggcg gggagccggg acagacgctc cagcccctcg acgatcgtgg ccgaccacag
    16561 acggccgaac tcggcggtcg gtaccgaccg ttggtacagc gggcgcagat cggcgtcgtc
    16621 gtcgctgagc agcgcgtcga gaccggccgg aaggtcctcg gtggtctcgg cgcgctccgt
    16681 catcagctgg atcagccgga agccggggtg gcggctcatg gagagcgcgc agtcggcgcc
    16741 gtcccggtgg aggtggacga accgggcctc gggaaagacc tcccgcagcc ggggcaccga
    16801 ccgcagcgag tagcccgacc gctccacgac ggcgcgtcgg ccgaaccgct cccccagcag
    16861 gccgaacagt gcccggtagt gatcggccac cggggctgcg ggccgccggg tcagctccgg
    16921 ctccagcgcg tcgaacagcg cgtcggggtc gtcggtgaga tgcggcagcg tcatcatgca
    16981 cagggccgga atgccaccgc cggacaccga gaaccgcccc tcgacatgcg gataccggta
    17041 ctccggcagc gggatgccat cgcggatgac gcggttggcg aacgagcgcg gagtggcgag
    17101 aatccgccag aactgcgccc cggtcagcgg cgcctcgggc agcgcgtccg gctccagcga
    17161 ggcgatcagc tcgctcacgc tgagcagatc cggatgcagc cgcaggacgc gcgacagtgc
    17221 ggtggaaccg catcgtccgg tccccacgac gaaggtcagc ggccgtacgc tcaccccagg
    17281 tgccccttcc gtctcgacga ctaccgaccc tgtctaccca ccgccaccgc cgtgcacccc
    17341 cggccacccc cgtcactggt gaggtctccc gccactggtg ggacttctcg tcacaggcgg
    17401 aggccacccg cgctcttgag gtcggctcgg cgtgaccgta cgttccaccg gacggccacc
    17461 gcaggacacg ccccccacac cgcgggggcc gacacttggg ccgacaccgc accttcaaga
    17521 ccttggagga gccatgcccg cacctgtgtt cagccgccgt cgcggtatgc gcgtcgcggc
    17581 cgcggcggcc gtcgcgcttc cgctcgccgc ccagccgcag tacgtggcca cggcggtccc
    17641 cgccgccccg gtcgcccccg ccgacggtcc acggctggcc gccatgacct tcaatctgcg
    17701 ctacgccagt gacagcgagc ccaactcctg gggccggcgc cgcccggtca tgcgggagct
    17761 gctgcgccgg gcccggcccc atctgctggg cactcaggag gggctgtacg gccagctgcg
    17821 tgatatcgcc caggacctcg ggcagcgcta ctcctggatc ggcgtcgggc ggatgggcgg
    17881 cagccgcgac gagttcatgg ccgtcttcta cgacaccggg cggctggaac ccctggagta
    17941 cgaccacttc tggctgtccg acaccccgaa tgtgatcggt tccaacacct ggggcggggc
    18001 cgtggtccgc atggtcacct gggtgcgctt ccacgaccgg cacaccggca aggagttcta
    18061 cgccctcaac acccatctgg accaccgcgg ccagaacgcc cgtgagcacg ccgccgctct
    18121 gatcaccgag cggctcggcg gtctggactc cgcgctcccc cgcatcgtga ccggcgactt
    18181 taatgtggcg gcccatggca accccgtgta cgacgccatg ctgaacggcg ggacgctggt
    18241 ggacacctgg gacaccgccg agcggcgcgg cccgctgtac gggacgttcc acggcttcgg
    18301 cccgctgacc cccgacggcg accggatcga ctggatcctg acctcgccgg gggtgcgcac
    18361 ccgccacgcc gccatcgaca ccttctccca ggacacccag taccccagcg accatctgcc
    18421 ggtgcggacc gtcctggagc tgtgacgccg ggcggccgcg ccggacgccg tcgatccgct
    18481 cctccggggg cggatcgacg ggtcggcggg ccctcagcgg tcggccgtct ccgccgagag
    18541 cgcccgcacc cgcagcaggg tggccacggc cagcagggcc acacagcccg tgaagacgag
    18601 cccggcggtc cgcagcccga ccgcgaccgt cagcgcgccg acgccgatca ccggaatcga
    18661 gatcgccagg tacatcagca cgaagagggc ggaggtgacc tcggcgcggc ggtcggccgg
    18721 gctgcgctcc gtcaccaccc gtacggccgc atggaacgac agcccctggc ccgtccccgc
    18781 caccacggcg cccagcacca gcagcgcgag cgacgcgatg gccagcgaga ccgcgatggc
    18841 cgccatcccg gccaccagca ccgcgcaccc tccgggcagc gaccaccccg cgccgagccg
    18901 ccgccccagc acctgcccgg cgatcgaggc ggcgaacacg gagaacgcca cggcaccggc
    18961 gaccgcgaga ttgctctccc cctccacctc gctcaggaac gtgggcgaca ccgaggtgaa
    19021 caggcccagt gtggcgaagc ccgcgaaccc cgccatggcc gcggccgcga acgtcgagcg
    19081 catctccttg ggcacccgca gccgctgcgg cctcagcggc ggacggctcc gcgtccgtac
    19141 ggtctccggg agggccagca ccacggcggc ggccaccgcc accagcacca ggtccaccac
    19201 gaacaccagc ttcagcggcg ccggggcgta ctgcgccagc acccccgcca gcaacgggcc
    19261 gacgccgagg ccgcccaggt tggccccggt ggcgaggaga gtggcggcac ggcgtcggct
    19321 cggcggcgcc agctcgatca ccgtcacggt ggcggtgccg gtggccagac cggcggacag
    19381 ccccgacagg gtgcggcccg cgaacagctc cggcagtccc cgggcgagca ggaaacacac
    19441 cgcgctcagg gccgacagca ccagcgcggc cagcatgacg ggccgtcgcc cgatgaagtc
    19501 ggacacgctt ccgagcagca gcagcgcgac gatgaccccc gccgcgtata cggcgaagat
    19561 caccgtgacc atgaacgagg agaagccgaa ctcccgctga tagagcgagt agagcggcgt
    19621 gggcagcgtc gtaccgcaca tcgtgaccac gaaggcgtag gcggccgcga gatacggcca
    19681 cgctctgctc acgtcgtttc gacggctttc catgcgatct gattccacca cacatcacat
    19741 gtccgtcaaa cgcggtgacg cgccgcccgc cgcctggcgg gttacgtgcg gtagcggggc
    19801 atcccgtcat tcggccctca tcccatgcgg caggatggca cctcacgccg gagccgtaca
    19861 catgtacgcc ggcacagccc gtacacccca ggtacaagca ggtgacatgg tgatcccaca
    19921 aacctccaga ccggaggccg caccgacgac ggcatgccgt acggccactt ctgacgcgct
    19981 gtccggcacc ggggggagtg gtcgatgaac cgggctctca ccttgcacga tgtcatcgtc
    20041 gtcggggcgg ccctggtatg cggcgcggcc ggtggtgtgt tgttgcgcct ggcactgcgc
    20101 tggctgggtg agcgggcccg cgccacccgc tggagcggcg acgacatcat cgtcgacacc
    20161 ttgcgcaccc tggcgccgtg ggcgtcgatg gccgccggtg tggccgccgc ggccgccgcg
    20221 ctgccgctga cccccacggt cggccatgac gtcgatcaga cgctggtggc cgctctgatc
    20281 ctggtcacca ccgccacggc ggcgcgagtg gtggccgatc tggtgcgctc actggcgctg
    20341 tcccgctcag gcgtggcggg cacggccacc atcttcgtca acatcacgcg gatcgccgta
    20401 ctggcgatgg gtgtgctgat cctgctggag acgctgggcg tctcgatcgc cccgctgctc
    20461 accgcgctgg gcgtgggagg tctggcggtc gccctggccc tccaggacac cttggccaac
    20521 ctcttcgcgg gggtgcacat cctggcctcc aagacggtgc agcccggcca ctacatccgg
    20581 ctcagcagcg gggaggaggg gtatgtggtc gacatcaact ggcgcaacac ggcggtgcgg
    20641 cagctgtcgg acaacctcgt catcatcccg aacgccaagc tgggcaacac catcatgacc
    20701 aactttcacc agcccgagca gcagatgtcg gtcatggtcc aggcgaaggt cggctacgga
    20761 agcgatctgg accatgtcga gcgggtgacc gtcgaggtcg ccgggaaggt gatgtccggt
    20821 gtcgagggcg gcgtcgtcga ccacgaggcc agcgtgcgct tccacacctt cggagagtcc
    20881 ggcatcgact tctcggtgtt tctgcgggcc ctggagttca gcgaccagta cctcatcaag
    20941 catgagttca tgaaggagct gcaccgccgg ttccgcgccg agggcatcga gatcccgctg
    21001 cccacgcgta cgctcgtcct gcccgaccag gaccgcgttc cgctgccggg ccgcccggcg
    21061 atctgacgcc gtcagggcag cagccgccgc tcggtggcca ccgccaccgc cccggcccgg
    21121 gtctcgaccc ccaatttccc gtagatccgt cccagatggg tcttgaccgt ggcctcgctg
    21181 atgaacaggg cccgggcgat ctcccggttg cccaggccgc gggccagctg ccggaggatg
    21241 tcgcgctccc gctcggacag cccggggcgc gggctgcgca tccgggccag cacccggtcg
    21301 gcgaccgggg ccgacagcgc ggtacggccg gaggcggcgt tccggatcgc cgcgaacagc
    21361 tcctccgggc gctcggcctt gagcagatag ccggtggccc ccgcctcgat ggcacgggtg
    21421 atgtcggcgt cggtgtcgaa catggtgagg accaggacgc gaggcgcggg tggatcgcca
    21481 cggaccagcc gccgggtggc ggtcaccccg tccataccct ccccgagctg gagatccatc
    21541 agcaccacat cgggccgcag ccgggtggcc atggcgagag cctcctcgcc gctgcccgcc
    21601 tcgccgacca cctcgatccc ctcggtgctg gccagcagcg cacgcagccc ggcccgcacc
    21661 acggcgtggt cgtcgcagag cagcagccgg atggcgggcg cggacggggc cacgctcgga
    21721 gcggggccgg acgagaggga cggcgacggg cccgcggccg ggccggacga cgagggcgac
    21781 gaaggggacg gggacgggct catggcgtgg cctccacggg gcggtcgggg acgagggcgg
    21841 ggaggggctc cacggggatc gcggccgaga ccacggtccc ctcacccggt gtggactcca
    21901 cggtgagcgt gccgcccagc tgccgtaccc gggcccgcat ggccgggagc ccatgtccgc
    21961 gcgaccggtc cgcgccgggg gccgggacgg caccggtgtc gaagccacgg ccgtcatcgg
    22021 cgatgtccag acagatctga tcgcccatcc aggtcagggt gagcgcggcc cggcccgccc
    22081 cggcgtgctc ccgcacattg gccagcgcgc cctgggcgat gcgcagcagc gcggccgcca
    22141 cccgctcggg cagcgggccg agggggccgt cgagccggaa gtccaccgtc cgccccgggc
    22201 cgctctcccg ctcggcgagc gcgccgagcg cctgggccag ggagcgctcg gcgaggtcgg
    22261 ccggggccag gtcctggacg aaccggcggg cctcggcgag gctgcgggac gcgatctccg
    22321 ccgcgtcccg catatgtccg cgggccgcct ccggatccgt ctcccaggtg cggtcggcgg
    22381 cctggagcag catccgctgg ctggacagcc cctgggcgag ggtgtcatgg atctccgagg
    22441 acagccgctg gcgctcggcc aggatccccg cccgccgctc ggtcgcggcc agatcgcggc
    22501 gggtgcggac gagatcgtcg atcagcgtcc gctgccgggc cgactggcgc cgcagatgga
    22561 tgaggacggc ggcggccacg gcggcgatgg cgggcggcgc gatcagcgcg ttggggtcga
    22621 agccgtcgtg catgaaccgc agtttggagg cgacgaccag cgcggtgagc acggcggcca
    22681 ggggcaccgc gaaccgggtg ggcagggtgt gcagaccggt gaagaacagc ggcatggcgc
    22741 accatgcggc gctcggcgcg aggaccagca gtgcgaccca ggcggccagc accgcggtca
    22801 gccagaccag atagcggccg gagggacggc cgccggggcc cgacgcgggc gccggccacc
    22861 gtccgggcgg atagagcgcg ccgaaggcca cgaagagggc gatgacccag ccgttcggcg
    22921 cgccgccggt gtcccggatc agatagcgga ccagtgagga ccccagcagc aggaagaacg
    22981 cgatgtgcag gaccgccgtc agccagcgct catccggatc gtccggcccg tcggatccgg
    23041 accgcccgga ccaggccgac caggtggccg accacagcac cgaccacggc gcccgcccgg
    23101 accgcccgcc tgccccgacc gccctgcccg ccgaccgcac cccggcccct cctcgctccc
    23161 cggttcaccc cggatcctcg gttctcttcg ccgctcttcg attcgctccc ccagccagtc
    23221 ctaacgcgcc cggccggacg tcgcatcatc cgatcggttg atacgacgat cacccggatc
    23281 gcccgcggac cggggccgct ccaccgatcc ccgccgccgc cacggcgcag aggctggtac
    23341 cgaccagagc gacgcgggaa cgcataagcc gccgcgtccg cacctcgagc ccgagagagt
    23401 ccccatgccc gccaagaacc tcagcgtcaa tcgctccgcc ctcggccacc gcgtctccta
    23461 cgcgctgcgt catccgcagc gcgtcccgcg ccatctggtc cgcgccaccc gggacgcctg
    23521 gctgcgctac cgctacccgg accatgtcgc gtactaccgc gccgtgatgc ggtccgacac
    23581 ccgcaccagc ccggaagcgg cggtcggcag ccgcagccat gaccggtggc tggcgctggg
    23641 cgagatgcag ttcgactatc tcctcggcca cggtctgcgg ccggagcacc ggatgctgga
    23701 gatcggctgc ggcaatctgc gggcgggctg gcggttcatc ggccatctgg agccgggcca
    23761 ctactacggc gtggacatct cgcccgagat
//
