LOCUS       NZ_CP015588            22512 bp    DNA     linear   CON 05-MAR-2024
DEFINITION  Streptomyces alfalfae strain ACCC40021 chromosome, complete genome.
ACCESSION   NZ_CP015588
VERSION     NZ_CP015588.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces alfalfae
  ORGANISM  Streptomyces alfalfae
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8625867)
  AUTHORS   Gu,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-MAY-2016) Institute of Agricultural Resources and
            Regional Planning, Chinese Agricultural Academy of Sciences, 12
            Zhong Guan Cun South Street, Beijing 100081, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: SOAPdenovo v. 2.04; Celera Assembler v. 8.0;
            GapCloser v. 1.12
            Genome Coverage                   :: 310.8
            Sequencing Technology             :: Illumina; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 02:19:30
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,535
            CDSs (total)                      :: 7,444
            Genes (coding)                    :: 7,210
            CDSs (with protein)               :: 7,210
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 234
            CDSs (without protein)            :: 234
            Pseudo Genes (ambiguous residues) :: 0 of 234
            Pseudo Genes (frameshifted)       :: 107 of 234
            Pseudo Genes (incomplete)         :: 177 of 234
            Pseudo Genes (internal stop)      :: 26 of 234
            Pseudo Genes (multiple problems)  :: 73 of 234
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:53:12
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8347767
            Orig. end                         :: 8370279
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP015588.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22512
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="36"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22512
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22512
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12512](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12512
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            1291..1806
                     /locus_tag="A7J05_RS36490"
                     /old_locus_tag="A7J05_35660"
     CDS             1291..1806
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014180149.1"
                     /locus_tag="A7J05_RS36490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7J05_35660"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_076688183.1"
                     /transl_table=11
                     /translation="MSSPSAPAHTDVVTARLVLRSWTKSAATAVLGGARSPHWADDFPA
                     EGDRVIAGLFTQYPDWLGAYGHRLIIERDSGLVVGSIGLFWPPKDGVLEIGYGIVASRR
                     GRGYAPEATQALAEFALTAPDVHTVSADVELSNPASVRVLEKAGFHRWTTAGTIARFRI
                     ALPNHDRR"
     misc_feature    1967..1981
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.37"
                     /tool="antismash"
     misc_feature    1974..1992
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 21.81"
                     /tool="antismash"
     gene            <2100..>2282
                     /locus_tag="A7J05_RS41270"
                     /pseudo=""
     CDS             2100..>2282
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010981454.1"
                     /locus_tag="A7J05_RS41270"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="IS5/IS1182 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MEEAYPFRRNRRHLRRRQIKHTIQSRATSARASTPCQQRPSAHRL
                     ARTICQHRNEVEQTIN"
     gene            complement(2321..3010)
                     /locus_tag="A7J05_RS36495"
                     /old_locus_tag="A7J05_35665"
     CDS             complement(2321..3010)
                     /GO_function="GO:0018784 - (S)-2-haloacid dehalogenase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006805 - xenobiotic metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010982175.1"
                     /locus_tag="A7J05_RS36495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7J05_35665"
                     /product="haloacid dehalogenase type II"
                     /protein_id="WP_076688184.1"
                     /sec_met_domain="HAD_2 (E-value: 0.0012, bitscore: 17.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSELAIDAIVFDVLGTLVDEPAGIRAGIHELDPSLDDPGVEQLLS
                     LWQQHIDREQRRVLDGVRPYLTSDVLDLEAARLVADAAGVDDPAAVAALAMSGRRLPPW
                     PDTVAGLSRLAERFPLIGLSNASRTALLGLNAHAGLRWHQALSAEEARTYKPDPAVYQL
                     AVTVSGRPPERLLMVAAHAWDLRGAQSLGLRTAYVARPVGDPPTPSDGFDVHADDLAGL
                     AAQLDHP"
     misc_feature    complement(2999..3001)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    3219..3236
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 22.53"
                     /tool="antismash"
     misc_feature    3220..3238
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.23"
                     /tool="antismash"
     gene            3520..3969
                     /locus_tag="A7J05_RS36500"
                     /old_locus_tag="A7J05_35670"
     CDS             3520..3969
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018092127.1"
                     /locus_tag="A7J05_RS36500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7J05_35670"
                     /product="DNA-binding protein"
                     /protein_id="WP_076688185.1"
                     /transl_table=11
                     /translation="MSSTPEQPTDPFTPPQPEQARVHRAHASLFRIAERHAATDEQRHR
                     QVHPSVIGPHEAVRLVSFLLSGAAQLDDAEPEVDHADITAALSLVPMVRGEMDELETGL
                     LQMARGRGMTWQEIAFGLGLGTPQAARQRYERLASRAASDAEGPE"
     gene            complement(4580..5410)
                     /locus_tag="A7J05_RS36505"
                     /old_locus_tag="A7J05_35675"
     CDS             complement(4580..5410)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008745714.1"
                     /locus_tag="A7J05_RS36505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7J05_35675"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_205576637.1"
                     /transl_table=11
                     /translation="MPTLSQGQPDASGPEPHRHRQTAESFGVDAERYDRARPPYPQALV
                     DRIVTASPGLHVLDVGAGTGIEARQFQAAGCTVLGVEPDERMAAFARRSHIEVEVARFE
                     DWQPAGRQFDAVIAGTAWHWVDPVAGAAKAAQVLGPGGRLAPFHHVPQLPVELIDTLAE
                     ALQRVAPYSPFNPGLLKGSAVDAYQPLFTKIADGIRQTGSFTEPEQWRFTWERTYSREQ
                     WLDQLPTFGGLTQLPADKLAKVLDSAGTAIDKLGGHATMPYTSIVITSTRSHTV"
     misc_feature    complement(5399..5401)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            5472..6071
                     /locus_tag="A7J05_RS36510"
                     /old_locus_tag="A7J05_35680"
     CDS             5472..6071
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014054496.1"
                     /locus_tag="A7J05_RS36510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7J05_35680"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_237283500.1"
                     /transl_table=11
                     /translation="MPSGVHIHNVRGQLFEAAERVLLRGGPDALTSRAVTEEAGCAKGV
                     LHRHFTDFDAFLVELVLDRVHGIEDHATTLRAAAGTGGVVDNLADALQELFGPVTVAIV
                     ALITFRDSLRARLREAGLTGIPLVMQGTAMIAAYLTAERGMGRLAGDADIDTLAPTLVG
                     AGHLLFADRTNAPPQPDAIRKMVTTVIAGALRPLQP"
     gene            6395..6568
                     /locus_tag="A7J05_RS40120"
     CDS             6395..6568
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) darobactin_precursor"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A7J05_RS40120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_162933611.1"
                     /sec_met_domain="darobactin_precursor (E-value: 1.0,
                     bitscore: 7.0, seeds: 0, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWWWTGSTAGDSPQKALKAGALGRRVTVTGVTGVGFVFRPQPTIC
                     LLWHWGKRRRGG"
     gene            6879..8033
                     /locus_tag="A7J05_RS36520"
                     /old_locus_tag="A7J05_35690"
     CDS             6879..8033
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018087552.1"
                     /locus_tag="A7J05_RS36520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7J05_35690"
                     /product="N(5)-(carboxyethyl)ornithine synthase"
                     /protein_id="WP_076688189.1"
                     /transl_table=11
                     /translation="MQQLKLGIISQTRKENERRLPIHPAHFERIDADLQPSIYLQAGYG
                     EHFGVSDRQLAPWVAGFRSREELIAECDVILLTKPLHEDLAELREGQVLWGWPHCVQDE
                     KVTQAAIDRRLTLIAFEAMNHWTREGSFNLHVFHKNNELAGYSSVLHAMQLTGATGDYG
                     RRRRAAVIGFGATARGAVTALSALGVHDVDVLTARGVAAVSSPIHSARIVHFDHDVADE
                     TLDPRRSVVLTEHGPEPLADFLAGHDIIINCVLQDTAAPLMFLLEEDLPKLAPGTLVID
                     VSCDQGMGFAWARPTTFTEPMFTVGGHVHYYGVDHSPSYLWDAATWENSEALIPFLRPV
                     LEGPAGWDGNRTIHRAIEIRGGTVQNPAVLAFQHRAEQYPHALL"
     misc_feature    complement(8283..8292)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            9778..9900
                     /locus_tag="A7J05_RS39170"
     CDS             9778..9900
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056410.1"
                     /locus_tag="A7J05_RS39170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso RiPP family leader peptide-containing
                     protein"
                     /protein_id="WP_103557564.1"
                     /transl_table=11
                     /translation="MQSEKLVYDMPLIVEVGGFRELTRSVRPGHWIDFFGGWWL"
     gene            10001..11839
                     /locus_tag="A7J05_RS36535"
                     /old_locus_tag="A7J05_35700"
     CDS             10001..11839
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.4"
                     /locus_tag="A7J05_RS36535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7J05_35700"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_076688191.1"
                     /sec_met_domain="Asn_synthase (E-value: 8.7e-33, bitscore:
                     113.2, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFIVLPDHPAADAVLALSPRRAGDKVVRHPSGRPWVIGSWRDEE
                     LTAASAGSNAVVLLGRTRIGETELARKLAVMRSVTDMDSLSRSTHGCFHLLASIGSQVR
                     AQGSLTTVCQVFYGSVAGVAVAADRPQSVAALTGATIDEELVALRLLSPTAPHPLSQAC
                     LWRGVTALPPGHYLLMPANSDARPVRWWTPPEPSVPLAQGADTLRRALEAAVETRTAHS
                     ATVSTDLSGGMDSTSLCFLAAPRAARLVTYHHVPLDPSNDDGIWAGRCAADLPDARHVK
                     EHSGAAPAWYAGCLSTDEDVEGPFPLIRTRAKLEHLARTMAALGSTAHLQGIGGDELFH
                     ARAACAHALARAHPLRSARQVRVVRSMSRWTTSATIGYLLSGGTYARWLRSSAALLGPE
                     PRKRATGPAWESPPAMPVWATPRAVDAVRSLIRAAADGEPEPLAPLPVQHDMLSVAQLC
                     GEMTRRASRFTARHGVSYEAPYLDDRVVEAAMSVRLEDRIAAGRYKPVLATAMRDVLPA
                     YAQGRATKGDYSGELYSGLRQHRAELLELCEESVLVGMGLVDRVALRGLLLGLHPDTSP
                     FMAFDSTLACELWLRSLYRDNRSGTTASLPPNREEI"
     gene            11839..12096
                     /locus_tag="A7J05_RS36540"
                     /old_locus_tag="A7J05_35705"
     CDS             11839..12096
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019330917.1"
                     /locus_tag="A7J05_RS36540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7J05_35705"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_062769902.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 5.9e-19,
                     bitscore: 66.7, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 8e-10, bitscore: 37.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRFALPPHVTNTETEHGAVLLNEKTGRYWQANDAGARVLRCLLDG
                     GTAETAAAALRPGDPKAYERALRDVRAMIDGLRDAGLVIS"
     aSDomain        11848..12090
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_A7J05_RS36540_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="2.20E-21"
                     /identifier="RREFam002.1"
                     /label="A7J05_RS36540"
                     /locus_tag="A7J05_RS36540"
                     /protein_end="84"
                     /protein_start="3"
                     /score="66.7"
                     /tool="antismash"
                     /translation="ALPPHVTNTETEHGAVLLNEKTGRYWQANDAGARVLRCLLDGGTA
                     ETAAAALRPGDPKAYERALRDVRAMIDGLRDAGLVI"
     gene            12093..12512
                     /locus_tag="A7J05_RS36545"
     CDS             12093..12512
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033537.1"
                     /locus_tag="A7J05_RS36545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_076688192.1"
                     /sec_met_domain="PF13471 (E-value: 2.5e-22, bitscore: 77.8,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGLVTTEVSERPPFGLLLTARCAVVVAFGLARLSPGGLRRVLRL
                     ISVRARPAGHEQALRARKAVVAASVRCAGPWCLPRSIATALLCRVGGTWPDWHTGVCAE
                     PFRAHAWVVADGEPVGESNASLVPFHSVIVVRAGR"
     misc_feature    complement(12624..12638)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.64"
                     /tool="antismash"
     gene            12649..12870
                     /locus_tag="A7J05_RS36550"
                     /old_locus_tag="A7J05_35710"
     CDS             12649..12870
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A7J05_RS36550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A7J05_35710"
                     /product="hypothetical protein"
                     /protein_id="WP_123985647.1"
                     /transl_table=11
                     /translation="MRSFAAVLGVIIAMTAVSTSPAQAAAEERLIAHYHSKSGCLDAGA
                     RGKRQGKWATYRCLPSWDGPGPWGLWVS"
     gene            12933..15032
                     /locus_tag="A7J05_RS36555"
                     /old_locus_tag="A7J05_35715"
     CDS             12933..15032
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019330919.1"
                     /locus_tag="A7J05_RS36555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7J05_35715"
                     /product="histidine kinase"
                     /protein_id="WP_076688194.1"
                     /transl_table=11
                     /translation="MALGLLAAVLVVKLTVLSVSGEQWRAVHYSPPQTIAEVMRLAVGL
                     PVWVIGVLLLADRSGRGMGALLLAAGVVLVVPRTVSDLLAFIGDWSAPVDVTVLALAAV
                     ALAGHPLSVLVFPVCFLREPAVRRCRWYVIAPAAAAHAGHGALWFLGVPGAPPFFSPWS
                     GTATAQWALQHIGPVSHLVDWVSGAAALAVTAAVAHCSLSGDDAAERRRWLLLAVAYAV
                     CVSLLLGQWWPERWTMAARAGGGTVWVVVICLTVARSDVWRLQRATVHRLSVAFVLTVF
                     GTAAVGAALVAWAALPAVRSTASLTVAGCALLAGWVTRPVVVQSSLRVERFFYGSRARP
                     HHAMRKLVTRLQEAPDPRDVPEQICRSAVEDLGVSGAAVEVDTRSGVRRLGAVGVPVIE
                     PKQVFALRHHGQVVGRLEVARDGTSTPVERDSDLLSLLADQAGPALAALRLVEETQAAR
                     ESLVLAREEERRRLRREIHDGLGPQLAAVQMRLGTAQACVGPQSSAPRHLRAAAEGLSE
                     ALTEVRRITAGLTPAVLVERGLLEAIRILAHRLSTEVVQVVVADPATKMPVLAPAVETA
                     AYRIAAEAMTNAVRHSGARRVLVGLAVTPASLTVKVSDDGNGLPGGGVPGTGLASFTER
                     AEEIGGTTGVHTGPHGTAVHATLPLTRQGRELEEGHERPERRGPAGSCGTGTGTGTGSA
                     STAGG"
     gene            14944..15657
                     /locus_tag="A7J05_RS36560"
                     /old_locus_tag="A7J05_35720"
     CDS             14944..15657
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014176075.1"
                     /locus_tag="A7J05_RS36560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7J05_35720"
                     /product="response regulator transcription factor"
                     /protein_id="WP_237283501.1"
                     /transl_table=11
                     /translation="MSAQNDADRQDHAAPAPAPAPARRVLLVDDHPLFREGLAAAIDLD
                     DHFTVVAEAASGEAALTETARTDPDLVVMDLCLPGISGIEATRRLLTAHPHLRIMVMTM
                     SEDDDSLLAAMRAGAHGYLLKGALREEVLRALHTVARGGAVFGPQMTERLSALFAAFGR
                     TPAKEAFPTLTARERDILDLLAAGLTYRQIAQRLCVVEKTVRNHVGAIFSKLQVHDRAA
                     AIVRARDAGLGPQPQ"
     gene            complement(16069..16638)
                     /locus_tag="A7J05_RS36565"
                     /old_locus_tag="A7J05_35725"
     CDS             complement(16069..16638)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020114144.1"
                     /locus_tag="A7J05_RS36565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7J05_35725"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_237283502.1"
                     /transl_table=11
                     /translation="MDARVTTSAPARMRARHISSDVDCDAFIEEIYDQYGPLLVRYATR
                     LLDGDWHRAEDMIQEAATRAWKHARFLGARREHVRPWLYTVVKNLVIDHHRARRCRPLE
                     QVPAQELDAVWDGLETTLTSHVILEALKELNEQQRAVIHLMYYMECSVAQAAEYLGIPP
                     GTVKSRAFYAIRALRTTLAERGVVGQ"
     gene            17075..17905
                     /locus_tag="A7J05_RS36570"
                     /old_locus_tag="A7J05_35730"
     CDS             17075..17905
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Thioesterase (45-254). E-value: 1.9e-08.
                     Score: 27.0. Matches aSDomain:
                     nrpspksdomains_A7J05_RS36570_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005481660.1"
                     /locus_tag="A7J05_RS36570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7J05_35730"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_076688197.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.4e-18, bitscore:
                     66.3, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 5.4e-06, bitscore: 25.0,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSTRPSRRTTLAGLTALAALSTVTVALPGAAGASPRHKALPTIV
                     LEHGAFADAASWDGVVKRLQRSGYPVVAAANPLRGPANDAAYLRSVVDHIDGPVVLVGH
                     SYGGTVISQAAAGLEDKVKALVYIAAFLPDAGESSLGLTDKFPGSTLGQVIEPVNYTLP
                     DGGQGADVYIKPEKFRKQFAADVPADKARLMAAGQRPVAAAALEEKSTTAAWKAIPSWS
                     LVTTKDRNIPVAAQRFMSARAHAHTTEIDASHAVTVSRPDAVTRIVEKAARTAR"
     aSDomain        17210..17836
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A7J05_RS36570_Thioesterase.1"
                     /evalue="1.90E-08"
                     /label="A7J05_RS36570_Thioesterase.1"
                     /locus_tag="A7J05_RS36570"
                     /protein_end="254"
                     /protein_start="45"
                     /score="27.0"
                     /tool="antismash"
                     /translation="LEHGAFADAASWDGVVKRLQRSGYPVVAAANPLRGPANDAAYLRS
                     VVDHIDGPVVLVGHSYGGTVISQAAAGLEDKVKALVYIAAFLPDAGESSLGLTDKFPGS
                     TLGQVIEPVNYTLPDGGQGADVYIKPEKFRKQFAADVPADKARLMAAGQRPVAAAALEE
                     KSTTAAWKAIPSWSLVTTKDRNIPVAAQRFMSARAHAHTTEIDASH"
     CDS_motif       17360..17404
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A7J05_RS36570_0001"
                     /evalue="1.20E-05"
                     /label="NRPS-te1"
                     /locus_tag="A7J05_RS36570"
                     /protein_end="110"
                     /protein_start="95"
                     /score="17.9"
                     /tool="antismash"
                     /translation="DGPVVLVGHSYGGTV"
     misc_feature    17929..17944
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.85"
                     /tool="antismash"
     gene            17988..18821
                     /locus_tag="A7J05_RS36575"
                     /old_locus_tag="A7J05_35735"
     CDS             17988..18821
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (25-264). E-value:
                     5.1e-42. Score: 136.1. Matches aSDomain:
                     nrpspksdomains_A7J05_RS36575_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020116052.1"
                     /locus_tag="A7J05_RS36575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7J05_35735"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_076688198.1"
                     /sec_met_domain="PF00561 (E-value: 1.2e-29, bitscore:
                     102.5, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.5e-21, bitscore:
                     76.7, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAFITVGQENSTSIDLYYEDHGTGQPVVLIHGYPLDGQSWEKQAA
                     ALLKAGYRVITYDRRGFGRSSRPTNGYDYDTFAADLNTVLETLDLHDAVLVGFSMGTGE
                     VGRYLGTYGSARIARAAFLASLEPFLLKTDDNPEGVDGSVFEGIEQAVTADRYAYFTAF
                     CEDFYNLDENLGTRISEEAVRNSWNTAAGASWYASLACVATWTTDFRADVAAIDVPALI
                     LHGTADRILPIEATGEPFHRALPQAEYVVIEGAPHGLLWTHAQEVTDALLAFLAT"
     aSDomain        18063..18779
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A7J05_RS36575_Abhydrolase_1.1"
                     /evalue="5.10E-42"
                     /label="A7J05_RS36575_Abhydrolase_1.1"
                     /locus_tag="A7J05_RS36575"
                     /protein_end="264"
                     /protein_start="25"
                     /score="136.1"
                     /tool="antismash"
                     /translation="PVVLIHGYPLDGQSWEKQAAALLKAGYRVITYDRRGFGRSSRPTN
                     GYDYDTFAADLNTVLETLDLHDAVLVGFSMGTGEVGRYLGTYGSARIARAAFLASLEPF
                     LLKTDDNPEGVDGSVFEGIEQAVTADRYAYFTAFCEDFYNLDENLGTRISEEAVRNSWN
                     TAAGASWYASLACVATWTTDFRADVAAIDVPALILHGTADRILPIEATGEPFHRALPQA
                     EYVVIEGAPHGLLWTHA"
     gene            complement(18912..22169)
                     /locus_tag="A7J05_RS36580"
                     /old_locus_tag="A7J05_35740"
     CDS             complement(18912..22169)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005481642.1"
                     /locus_tag="A7J05_RS36580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7J05_35740"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_237283503.1"
                     /transl_table=11
                     /translation="MRALGQELDFGLLGPLVVRRAGEVLDPGRRKQRLLLVRLLLADGC
                     AVTPQTLCEDLWAEEAGRAPGGAMASLHAHVSKVRAVLEPQHLRVRGTFAVLVTEPAGY
                     ALRVPPESRDTVRFERTAARAHQLLGQGQPEHVLRETDRALGMWRGAALADAAHHLFAA
                     HESARLEELRQTVRETRTTALLLSGRLPEAVDAAQELTREHPLRETGWALLLRALYLAG
                     RHPEALGHYADLRRRLADGLGLEPGPALRALHEGILRHELPPLPLPGTAGQPARTADRG
                     CPGHPAAPAASDGKPAASPGGQDVTGPAGARPAAATGPDADPSDISGDAVARGPAGEAS
                     PAGTVAGASAGPAGPADAHGHRPGDSGAEDIRPVRPAQLPRDLPVFAGRAAESAWLSAV
                     NGAPGRPAPSGAPVVVIGGAPGVGKTTFAVHHAHRIASSFPDGQLFVNLCGFHPTAPAV
                     EPGDALHGFLTALGVPAQRIPEDTDGRSTLFRSLLAGRRVLLVLDNARDEQQVRPLLPA
                     GGGCLTLVTSRNRLPGLIATEGAKTLTLALPSQAEAHETLTRRLGAERLDAEPAATADI
                     IQLCGRLPLALAVVAARAELDPTFPLHAVADDLRHAHGGLEAFTGFDDTTDVRSVFSWS
                     YRSLDEAVARLFRLLALHPGPDITAAAAAGLAGLPLPRAQRLLSVLTRSCLVEQPLPGR
                     YALHDLLRGYATELTHTHDDTSERHHATLRVLDHYMFTAYQGNRLFKQDSLPELDLGSP
                     SADVTPEDLTTVGQANRWFAAEHRVLAALLHTAVGQRMDHHITGLAWSLKEYLNRQEYW
                     PEAITALTPALDVARRRGDRLEEGRCLRHIGGIHGYLGHEEQALCHLNRAITILDELGA
                     VGEQARAHYALACALHLFGRTPEAVVASERGLALSRATGDQLWTAECLVELAWFHSNLG
                     QHEKGLTLSQEAMSLFQLLDAPWQQAQNWDVLGHILRQLGRYEESVTTYRQAVEAFEEL
                     GDQRNAVGALMRLGDTRLAMGDSEAARAEWTRALAGAEQHALSRSAQEVRERLAALDSE
                     MPLDPAASAESAGDARAPAPASGAPAHKVPVPVSRQV"
ORIGIN
        1 cggatcgctt tcgagccgta gcccttgtcg cccaagacgt gatcgggctg ggtgcggggt
       61 cgtcctgggc caaggcgggg cacccggatc gctttcatca cagtggtgaa ctcggtgcag
      121 tcgttggtgt tgccgcccgt gacggcgaag gcgagcggtc ggccccggcc gtcgcaggcc
      181 aggtgaatct tgctggtcag accgcctctg gaccggccga gggccgggtc gcggagcccc
      241 cttttcgggc cccggccgca tgctggtggg cccggacgat ggtggagtcg accgagacca
      301 gccactcgat gtcacccgcc gcgtccgcct ttgcctgcgc ggcccgtagc atccggtcga
      361 acgttccgtc cgccgctcac ctgcgaaaac gtctatgcag tgtcgcccac ggcccgtagc
      421 gctcgggcac gtcccgccag gccgtgccgg tgcggaacct ccacacgatc ccgttcagga
      481 cccggcgatc gtccagccgc ttccgccccc gcaacggctc aggcagcaac ggccggacga
      541 acccccactc ggcatcgggc agttcatggg cgttgagagc ctgggcccgc agcgtcgcat
      601 gcttgcgccc cggaatggac acgtcgccag gggaggccat cagctgggtg tcgcgttgtg
      661 cctcggtgca ggcaactcat tggtgttccg gaatctcgat cagcttcggg cttggcacac
      721 caggcacccg ttcagccgag ccagtccgtc actgggggcg ctgttcatgc gagcgtgccc
      781 acgagtgctg gccgaagtgc ggcagccaca ggcggtggca gtatcactgc cccctccctg
      841 cacaccgccc ggcggcggtg aagtgcggtg agcacaccgt gtcttgtgcg gcttctcccc
      901 gggagggggg ccgcagtgcc tgggggcagc cgctcaactc ggcgcactcc tcgggtgacg
      961 cggccatcga ctgagctacg gcgtggggaa gggcggcctg agtggatggt ctgccacggg
     1021 ctgtagcccc tctgctgtgc atgaccagag caacgagccg tcactcgccg gaggcacacc
     1081 cttcagcgag tgaaggcctc gggcagcgtc ccggaaatgt gttgccctgg ccggaaagtg
     1141 gctactaccc tcgcgccagc gtgacagacg cgtgatctcg ggatgaggag gttgatgaat
     1201 atggccgccg tcggccttca tcggcatgcc cttgtccggc ccgtgcgata acagagcgcg
     1261 gccggtcgtt ccaacgacca ggagatacac atgtcttccc cttctgcacc cgcccacacc
     1321 gacgtggtca ccgcgcgcct cgtactgcgg tcctggacca agagcgcggc caccgcggtc
     1381 ctcggcggcg cccgctcccc tcactgggcg gacgactttc ccgccgaagg cgaccgcgtg
     1441 atcgcaggcc tcttcaccca gtaccccgac tggctcggcg cctacggcca tcgcctgatc
     1501 attgagcgcg acagcggtct ggtggtgggc tccatcggcc tgttctggcc gcccaaggac
     1561 ggcgtcctcg agatcggata cggcatcgtg gcctcccgcc gcggccgggg ttacgccccc
     1621 gaggccactc aggccctggc cgagttcgcc ctcaccgcgc cagacgtcca caccgtgtca
     1681 gcagacgtgg aactgtcgaa cccggcctcg gtccgagtac tggagaaagc cggcttccac
     1741 cggtggacga ccgcgggcac catagccagg ttcaggatcg cgctcccgaa tcacgatcgg
     1801 cgctgactgt gcggggtcct ggagggatgc cgccaggacc ccatcgcggt ggccgagtcc
     1861 ccgggcaacc accgtgttcg gagagacaag acccggatga gcagaccggc ttggcccggc
     1921 gctgtgacgg cggcggacgc gggacgcggt ctgccaatgg acacacggtc gacttcggcc
     1981 aggctgacct ctccggctcc ccctctacga gtgccctgca caaccggccc gcgtatgcgc
     2041 gcgcgagatc gaggggggcg tgtcggccct cttgaggtca ttacgagaca ggttttttgg
     2101 gagaagaggc gtaccctttc cgccgcaacc gccgccacct acgaagacgc cagatcaagc
     2161 acaccatcca gagccgggca accagcgcgc gagcgtcaac gccgtgccag cagcggccgt
     2221 cggcccaccg gctcgccaga acgatctgcc aacacaggaa cgaagttgag caaacgatca
     2281 acgccccgac tctggcacag ccgatgaccc gtcggtgctc ctagggatgg tcgagctgtg
     2341 cagccagccc ggccagatcg tcggcgtgca cgtcgaatcc gtccgaggga gtgggcgggt
     2401 cgccgacggg gcgagcgacg taagcggtgc gcaggccaag gctctgcgct ccgcgcaggt
     2461 cccaggcgtg ggcagcgacc atcaggagcc gctccggcgg tcgtccggag acggtgacgg
     2521 ccaactggta gaccgccggg tccggcttgt aggtccgggc ttcttcggcg gacagggcct
     2581 ggtgccagcg tagtcccgcg tgggcgttga gccccagcag cgccgtccgg ctcgcgttgg
     2641 aaagtccgat cagtggaaac cgttcggcca gtcgggaaag ccccgccacg gtgtcaggcc
     2701 acggcgggag cctgcgacct gacatagcca gcgccgcgac ggcggccggg tcgtcgactc
     2761 cggcggcatc ggctacgagc cgggcggctt ccaggtcgag gacgtcactg gtgaggtagg
     2821 gccgcacacc gtcgaggacg cgacgttgct cgcggtcgat gtgctgttgc cacagtgaca
     2881 aaagctgctc gaccccagga tcgtcgagcg atgggtcgag ttcatgaata ccggcgcgaa
     2941 taccggcggg ctcgtcgacg agcgtaccga gcacgtcgaa cacgatggca tcgatcgcta
     3001 actctgacat gagttctcct ggtcgaagca ggcgcctacg gggggctgtt agtcgaacgc
     3061 agggggacgc cgccctgatt cccggaccgc acggcctgtg gggcaaccgc atcaacgtcg
     3121 ccagccaccg cgcccgccaa gccacaactc gcgagcggcg cacgacctcc gcgtagtccc
     3181 agagctagcg accgacagct cagccggacc agggaccctg acctgtagac cggatacgga
     3241 gaaggaatgc ggcggcgaat cggcggcgtc acgccgggct ggatcagtgg agcagggtgg
     3301 tttcggggca agtgcgcggc gcagtcggcc gactggatct ccccgagaac gcccagcacc
     3361 ttgccgaatc ctgccctggt gcatggccaa cacccgcccc gccgcaacgg ccgagagtca
     3421 ggaagtttcc gcgccgcaga agttcccgcg ctcacgattg aacgagtcgt ttaaaacggt
     3481 ccgttgacaa cgattcatga aatgcctcat cctcttctca tgtcgtcgac tcctgaacag
     3541 cccactgacc cgttcactcc tccgcagccg gagcaggcgc gagtgcaccg cgcacacgcg
     3601 tccctgttcc gcatcgccga gcggcacgcg gctaccgacg agcaacgcca ccgacaggtt
     3661 cacccctcgg tcatcgggcc gcacgaagcc gtcagactcg tgtcgttcct gctcagtggg
     3721 gccgcacagc tcgacgacgc tgagccggag gtggaccacg ccgacatcac cgccgcactg
     3781 agccttgtcc cgatggttcg cggcgagatg gacgaactcg aaaccggact tctccagatg
     3841 gcacgtggcc gcggcatgac gtggcaagag atcgccttcg gcctcgggct cggcactccg
     3901 caagcagcca ggcagcgcta cgaacgactg gccagccgtg ctgcatccga cgcggaaggc
     3961 ccggaatagg aagggcccgc cccggattgc ccaggggcag gggcctgggg ctgctgcacg
     4021 cgggcgcatg ccgatcctcc acaggcggac gccgggcccg ggttcttggg ggaatgcggc
     4081 ggcggcagtg ctcggttcga tgctctgcgc ccggacgcgg cagcgatgct tttcgtggcc
     4141 ggatctgcgg tcgccgagca gggttccagg tgcgccgtcg cgggcgttcg accaggcccg
     4201 ggatggatgg aaccgccggt cagcgcgtcg cgaatgggat gctttgcccg tcgcctagga
     4261 cgtggtgcgt gctacctgga cgtgcgcggc cgaccgggct cggtcccctt ctgtaccccg
     4321 ccgagcggcc cgtaggtggc tgaaggcgat caccgtccgg gaccagccca gttacttcgt
     4381 caccggcagt tacgtcagca ggacggcatg gagttgatcc cacacccggc ctgctggaca
     4441 gacacccgcg gccgcccggt ggtggccctg ggcccggcat gctgatgccg gccaggtgct
     4501 cgaaccccgc tgcctccccg ggggtgtcgc cgagctcatg ggcttgcgcg tgcccggcga
     4561 cgcccgacgt ttgcggcgat cagaccgtgt gggagcgggt cgaggtgatc acgatggacg
     4621 tgtagggcat ggtggcgtgg ccgccgagct tgtcgatcgc ggtcccggcg ctgtccagga
     4681 ccttcgccaa tttgtctgcg gggagttggg tgaggccgcc gaaggtgggg agctggtcga
     4741 gccactgttc tcgggagtag gtgcgttccc acgtgaagcg ccactgttcg ggctcggtga
     4801 agctgccggt ctgccggatc ccgtcggcga tcttcgtgaa cagtggctga taggcgtcca
     4861 cggccgatcc cttcagcagg ccggggttga acggagaata gggggcgacc cgttgaagtg
     4921 cttcggcgag ggtgtcgatc agctcaaccg gaagttgggg gacgtggtgg aaaggggcga
     4981 gtcggccgcc gggcccgagt acctgggcag ccttggccgc gccggcgacg gggtccaccc
     5041 agtgccatgc ggtgccggcg atgaccgcgt cgaactgccg gccggccggc tgccagtcct
     5101 cgaacctggc gacctcgacc tcgatgtggc tgcgtcgtgc gaaggcggcc atccgctcgt
     5161 cgggttcgac accgagcacc gtgcagccgg ctgcctggaa ttgccgggcc tcgatgccgg
     5221 taccggctcc gacgtcgagg acgtgcaggc cggggctcgc ggtgacgatc ctgtctacca
     5281 gggcctgggg atacggcggt cgggcgcggt cgtagcgttc ggcgtccact ccgaacgact
     5341 cggctgtctg ccggtgacgg tggggctcgg ggccggatgc gtccggctgc ccctgcgata
     5401 aagtgggcat gcgcccaccc tagtgggcgg acgcccactt gttaagccgg agcgggttcg
     5461 aaggggagac aatgccgtca ggggtgcaca tccacaatgt gcgcggccag ttgttcgaag
     5521 ccgccgagcg tgtcctgctt cggggcgggc ctgacgcgtt gaccagtcgg gcggtcacgg
     5581 aggaggcggg ctgtgccaag ggcgtgctgc accggcactt caccgacttc gacgctttcc
     5641 tggtggaact ggtcctcgac cgcgtccacg gcatcgagga ccacgccacg actctacgcg
     5701 cggccgccgg caccggcggc gtggtggaca acctcgccga cgcgctgcag gaactgttcg
     5761 ggccggtcac ggtggcgatc gtcgcgctca tcactttccg ggacagcctc cgcgcccggc
     5821 tgcgcgaagc cggtctgacc ggcatcccat tggtcatgca gggcaccgcc atgatcgcgg
     5881 cgtacctgac cgccgagcgg ggaatgggac gtctggccgg tgacgccgat atcgacacac
     5941 tcgcccccac cctcgtcggg gccgggcacc tgctgttcgc cgaccggacg aacgccccac
     6001 cgcagcccga cgccatccgc aagatggtga ccactgtcat cgccggcgcc ttgcgaccac
     6061 tccagccgta ggtcggttcc ccgggtcagg cgacggggga ctgcaccccg gcctggtccc
     6121 cgtagtccgg ctctacggtg gcggtttctt ctgcgacgcg ggccaggccc cccatcgcct
     6181 gtggaggtac acggagttgg ccaccacggc gctgggcgag atgaactcgt cggcgctgat
     6241 ccctcgaaaa cctcggagct ctctcgatgc ccaccggcgg gccaacaaag cccggccggg
     6301 tcggtgcccg ttgctacgtt cagaacaggg tgagtgtgag accgggggcg gcggccatct
     6361 ccaggccctc gtaggcgagg tgaggtcgtc ggcgatgtgg tggtggaccg gctcgacggc
     6421 gggcgactcc ccgcagaagg cgctcaaggc cggggctctc ggacgccggg tgacggtgac
     6481 cggtgtgacc ggtgtcggct tcgtgttccg gccgcagccg acgatctgcc tgctgtggca
     6541 ctgggggaag aggagacgcg gcgggtgatc gaggccacgc gcacgaggac gcggtcgagc
     6601 ggatgttgga gtggatcgag gtggaggtga tccggcaccg caatgacggc atccaccggg
     6661 tgtggccgcc ccacggcccg gtcgtcgcgc gcttccgcca ccacgaggcg cgctccggga
     6721 ggcccttgcg gcacgacgcg cagcgcgcgg ccctccctca cagggcccgg ggccgtcgtc
     6781 ggccgacgtc cgcaccgtag cgcggaccca taggagcact gccgatcaag ccccttggct
     6841 gcagggtgtg ttacacaggt agcaatcaga ggggtatttt gcagcagctc aagctcggaa
     6901 tcatttcgca gacccgcaaa gagaacgaac gccgtctgcc gatccaccca gcgcacttcg
     6961 aacgcatcga cgccgacctt cagcccagca tctacctaca ggccggttac ggagagcact
     7021 tcggtgtgtc ggaccggcaa ctcgcaccat gggtcgccgg tttccgctct cgcgaggagc
     7081 tgatcgcgga gtgtgacgtc atcctgctga ccaaaccgct gcacgaggac cttgcggagc
     7141 tgcgggaagg acaggtgctg tgggggtggc cgcactgcgt gcaggacgag aaggtcacgc
     7201 aggccgccat cgaccgcagg ctcacactga tcgccttcga ggcgatgaac cactggaccc
     7261 gggagggttc gttcaacctg cacgtcttcc acaagaacaa cgaactggcc ggctactcgt
     7321 cggtgctgca tgccatgcag ctgaccggag cgaccggtga ctacggacgc cgacggcgtg
     7381 cggcggtgat cggcttcggc gccaccgccc gcggcgcggt gaccgcgctc agtgcgctgg
     7441 gcgtgcatga cgtcgacgtg ttgaccgccc gcggggtcgc cgcggtcagt tcaccgatcc
     7501 actccgcgag gatcgtgcac ttcgaccacg acgtggccga cgagaccctc gacccccggc
     7561 gcagcgtcgt gctcaccgag cacggcccgg agccgctggc cgacttcctc gccggacacg
     7621 acatcatcat caactgcgtg ctccaggaca ccgcggcgcc gctgatgttc ttgctggagg
     7681 aggacctgcc gaaactcgcc cccggcaccc tcgtcatcga cgtctcctgc gaccagggca
     7741 tgggcttcgc ctgggcgcgg cctaccacct tcaccgagcc gatgttcacc gtcggcggcc
     7801 acgtccacta ctacggcgtg gaccacagtc cctcctacct gtgggatgcc gccacctggg
     7861 agaacagtga ggcactgatc cccttcctgc ggccggttct cgaaggaccg gccggctggg
     7921 acggtaaccg cacgattcac cgagcgatcg agatccgcgg cggcaccgtc cagaaccccg
     7981 cagtcctggc cttccagcac cgcgccgaac agtatccgca cgcactgctc tgagccgacg
     8041 cctctggtcg acggcacacc cacaccgggt atgccgtcga ccagaggccc cggccttctg
     8101 ccggccgtgg ggcgtatctc gccgattccc ggacctggcg tcgcttctga ggacaagatc
     8161 gtgagcccca aggcgtgtcc cggaacgaga cagccgcgaa cagctcaggc ctgcggcggg
     8221 acggaacatt cccaatgagg gccgacaact cgatccacac cacggccctg catgagaaca
     8281 caggccgcct tcgcggacct cgggttggca accgagccgc gcatcgtcac cccggggcgc
     8341 ctgccggtga tggagatcgc cggggtgccg catgagctga tccgctggac tgcccggcgc
     8401 agcgaccaga ccgccgcctg cctggccggg ctggagcacg agtacgtcac cgccgtcgac
     8461 gacggcgagc cgcgtttcct gcccgtgctc tccgagcggg ctcgcgccaa gctgaacgcc
     8521 gtggccgccc gtacgacccg ctcgcgcagc tgcgcgcatg gtggaagaag agcgcgatcc
     8581 tcacctccgg agtcgctgtc gacgtcatcc cctccctcct cgaccacgcc cgcgccgcgg
     8641 ctaccgcgat ccgggcccgg gccgccgccg tggtcgatgt cgcctggcgg ccgtcgacgt
     8701 cactgcgacg gtgttcctga tggacgaggg cgggcgctga caccgtcggc accggctcgc
     8761 cgaagcccga cgccaccttg ccctcgtcct gcgcggccac caccgcgacc ccggcctgga
     8821 tgaccaggtc gtggctgccg ccatctcgac ccactgcctg gacatcagcg aaccgaagac
     8881 cgtacgcggc ctggagcgcg gtcatcgcct gcaccacccg ttggcccctg cccgacctcc
     8941 ccgcttggaa ccgcccaccc actcccgcgc tcgatccgga gcggcaactc ctgtccgatc
     9001 ccggagagtc ggccgcgccc cgggcttcgg accaggccac gggggagtgg gagatgccct
     9061 gggcgtaggt cgccgtccac cagcaggcga cgatgcccga gcaactgctc gcgcccccgg
     9121 ccaccgaccc tgagcccgac gaccagaagc aggagcccgg ccgccgcgag gcgctggatc
     9181 cgacggcgct cgggccgacc ggctgcgccg cctccaggac gcgttcgcca agggggcgac
     9241 gactcccgtg tccgcgcgga ccgctatacc ggccaggacg gcgttaccgg ccggtgcgcc
     9301 cggacggtcg gcaggcgcac cacccacagg gtccggacca taccgaggcc gggaaaccgg
     9361 ccactgagcg cacccgatgg cgcgtacccg atggtgtgca cccggtgcgg tggtccgccc
     9421 agcacagggc gagcgggagc cccgccgccc catgtgtgcc gactgcggca ttggcatacc
     9481 gacgccggtg gccggcggga tggtccggcg gtactgccgg gagcgtgatg gtccgctgcc
     9541 ggtgacgatg acggcggccg cgatgttctg ctgagttcgg tgcggggcgt accgctcacc
     9601 gtatgagccg ggctgaggag ggggctgccg tcccggcgcg ttccgggacg gtcatggcgt
     9661 atggctcatg tgcctgggtc agcgggaagt cgatgctctt cttgtccgga tcagacgggc
     9721 ggcggatgga cggcagacct cgtccaccgc agacgacgag aagaaagagg tactcccatg
     9781 cagtccgaaa agctcgtgta cgacatgccg ctgatcgtgg aggtcggcgg cttccgtgag
     9841 ctgacccgtt ccgttcgccc cggccactgg atcgacttct tcggtggctg gtggctgtga
     9901 tcgagaccgc gctctgatgc gacggtccgg cacgtagcag aacaccgggc gatcggcgcg
     9961 aggcttcgcg tcgatcgccc actctgggac aaggaacccc atggaattca tcgttctccc
    10021 ggatcacccc gctgctgatg ccgtgctcgc tctgtcgccg cgcagggccg gggacaaggt
    10081 ggtcagacac ccctcgggcc ggccctgggt catcgggagt tggcgcgacg aggaactcac
    10141 cgccgcctcc gccggctcca atgcggtggt cctgctcggt cggacccgca tcggcgaaac
    10201 cgaactcgcc cgcaagctcg cggtgatgcg ctcagtgacc gacatggact cgttgagccg
    10261 ctcgacgcac ggatgcttcc acctgctcgc ctccatcggg agccaggtca gggctcaagg
    10321 cagcctgacc acggtgtgcc aggtcttcta cggatccgtg gccggggtgg cggtggccgc
    10381 cgaccggccc cagagtgtgg ccgcgctgac cggggccacc atcgatgagg aactcgtggc
    10441 acttcgcctc ctctctccca ccgcgccgca tcctttgtcc caggcctgcc tgtggcgagg
    10501 ggtcaccgcc ttgccgccgg gccattacct gctgatgccc gccaacagcg atgcgcgccc
    10561 cgtccggtgg tggacgccac ccgaaccgag cgttccgctg gcccaaggcg ccgacacact
    10621 gcgccgggcg ctcgaggcgg cagtcgagac gcggaccgct cactccgcca cggtgagcac
    10681 tgatctctct ggcggcatgg actccaccag tctgtgcttc ctcgccgccc cacgagctgc
    10741 ccggctggtc acctaccacc atgtgccctt ggatccgtcg aacgacgacg gcatctgggc
    10801 aggtcggtgc gcagccgatc tgcctgacgc acggcatgtc aaagagcatt ccggcgcggc
    10861 gccggcctgg tatgccgggt gtctgtccac cgacgaggac gtggagggcc cctttcctct
    10921 catccggacc cgggcgaaac tggaacatct ggcccgaacg atggccgcgc tgggttcgac
    10981 agcgcacctt cagggcatcg gaggggacga gctgttccac gcccgtgccg catgtgcgca
    11041 cgcgctggct cgcgcacacc cgctccgatc ggcgcggcag gtgcgggtcg tcaggagtat
    11101 gagccgctgg acgacgtccg ccactatcgg ctatctcctg tccggtggca cctatgcccg
    11161 ctggctccgg tcctctgccg ccctcctcgg cccggagccg aggaagcggg ccacggggcc
    11221 ggcgtgggaa agcccgcccg ccatgccggt gtgggcaacg ccccgagcgg tcgacgccgt
    11281 acgcagcctc atccgcgcgg cggcggacgg ggagccggag ccgctcgccc cgctgccggt
    11341 gcagcacgac atgctgagcg tcgctcagct ctgtggtgag atgacacgcc gggcctcccg
    11401 cttcaccgca cgtcacgggg tctcctacga agccccttac ctcgacgacc gtgtcgtcga
    11461 ggccgcgatg tcggtccggc tggaggaccg gatcgcggcc ggacgctaca aaccggtgct
    11521 tgcgaccgcc atgcgagacg ttcttccggc gtacgcgcaa ggccgcgcga ccaagggcga
    11581 ctacagcggt gagctgtaca gcggcctgcg ccagcaccgg gccgagctcc tcgaactgtg
    11641 cgaggagtcc gtgctcgtgg ggatgggtct ggtcgaccgc gtggcactga ggggactgct
    11701 cctcggcctg cacccagaca ccagcccctt catggccttc gattcgacgc tggcatgcga
    11761 gctctggctg cgatccctgt accgggacaa ccggagtggc acgactgcgt ccctcccacc
    11821 gaaccgcgag gaaatctgat gcgcttcgcc cttcccccgc atgtcaccaa cactgagacc
    11881 gagcacggcg cggtgctcct gaacgagaag accggccggt actggcaggc gaacgacgcc
    11941 ggtgcgcggg tgctgcggtg cctgctcgac ggcgggacgg ccgaaaccgc cgcggctgcc
    12001 ctgcgccccg gcgatcccaa ggcatacgag cgggcactgc gcgacgtacg ggccatgatc
    12061 gacggcctgc gtgatgccgg cctggtgatc tcatgagtgg cctggtcacc accgaagtgt
    12121 ccgagcgccc acccttcggt ctcctcctca ccgcacggtg cgcagtcgtc gtggcgttcg
    12181 gtctcgcccg tctctcgccc ggcggcctac ggcgggtcct gcgcctcatc agcgtccggg
    12241 cccgtcccgc agggcatgag caggcgctgc gtgcccgcaa agcggtggtt gccgccagtg
    12301 tgcgctgcgc cggcccgtgg tgcttgcctc gctccatcgc cacagccctt ctgtgccgtg
    12361 tcggcgggac atggccggac tggcacaccg gggtatgcgc ggagcccttc cgcgcgcacg
    12421 cgtgggtggt ggcggacggc gaaccggtcg gagagagcaa tgcctctctc gttccgtttc
    12481 attccgtcat cgtcgtgcgg gccggccgct gaaggggttc cggcacgtgt ccgcccttgc
    12541 gggccaacac gtgaaacaca acggccgatc agtcgttctt cctcatacgg aacgcgaacg
    12601 cgtgccgccg ctgaaggtgg aggaacgaga gtgatgatgt ggaattccat gaggtcgttc
    12661 gctgctgtgc tgggcgtgat catcgccatg acagccgtct cgacgtcccc tgcccaggct
    12721 gcggccgagg agcggctgat cgcgcactac cactccaagt cggggtgtct tgacgcggga
    12781 gcccggggca agcgccaggg caagtgggcc acctaccggt gcctgccctc ctgggacggg
    12841 ccagggccgt ggggcctgtg ggtgtcttga ggccggggtc ggtcgccgtc tccggccacc
    12901 cgcacgccaa gcccgtggca cgggcggccg gaatggcgct gggcctgctt gcggcagtgc
    12961 tggtggtgaa actgacggtg ctgtccgtgt ccggagagca gtggcgcgct gtccactact
    13021 caccgccgca gaccatcgct gaggtcatgc ggttggcggt ggggcttccg gtgtgggtga
    13081 tcggggtgct gctcctcgcc gatcgttccg gtcgaggcat gggggcgctg ctgctggccg
    13141 caggagtcgt gctggttgtg ccgcgtacgg tgtccgacct gctcgccttc atcggcgact
    13201 ggtcggcgcc ggtggatgtg acggttctgg cgctggcggc tgtcgctctc gccggccacc
    13261 ccctgagcgt cctcgtcttt cccgtgtgtt tcctgcgcga acccgccgtg cgacggtgtc
    13321 gctggtacgt gatcgcgccg gccgccgctg cccacgccgg ccatggggct ctgtggttcc
    13381 tcggggtgcc gggggcgccg cccttcttca gtccgtggtc ggggaccgcg acggcgcagt
    13441 gggccctgca gcacatcggc ccggtgagcc atctggtgga ctgggtgagt ggtgcggcgg
    13501 cgctcgccgt gacggccgcc gtggcccact gctcgctgtc cggtgacgac gcggcggagc
    13561 gccgtcgctg gcttctgctt gccgtcgcct acgccgtctg tgtgtccttg ctgctcggcc
    13621 agtggtggcc agaacgctgg accatggccg cccgtgccgg aggaggcacg gtctgggtcg
    13681 tcgtcatctg cctcaccgtc gccagaagcg atgtctggcg actgcaacgt gcgactgtcc
    13741 accgattgtc cgtggcgttc gtcctcaccg tcttcggcac cgcggcggtc ggcgcggcct
    13801 tggtcgcctg ggcggctctt ccggccgtac gcagtacggc gtccctgacc gtcgcgggtt
    13861 gcgcgctgct ggccggttgg gtcacccggc ccgtggtggt gcagtcgtct ctccgagtcg
    13921 agcgcttctt ctacggttcg agagccaggc cccaccacgc catgagaaaa ctggtgacgc
    13981 gattgcagga ggctcccgac ccccgggatg tgccggagca gatctgccgc agtgcggtgg
    14041 aggacctggg cgtgtcagga gcagcggtcg aggtcgacac ccggtcaggt gtacgcaggc
    14101 tcggcgcggt cggagtgccg gtcatcgagc ctaaacaggt gttcgctctt cgccaccacg
    14161 gccaggtagt gggtcgcctg gaagtggcgc gcgacggcac gagcactcct gtggagaggg
    14221 acagcgacct gctgtccctg ctcgccgacc aggcgggacc cgccctggcg gcgctgcggc
    14281 tggtcgagga gacgcaggcc gcccgggaaa gcctcgtact ggcccgtgaa gaggaacgcc
    14341 gtcggctgcg ccgtgagatc catgacggcc tgggacctca actggctgcc gtacagatga
    14401 ggttgggcac cgctcaggcg tgcgtcgggc cgcagtcgtc ggcgccgcgg catctgaggg
    14461 cagccgccga gggactcagt gaggcactga ccgaagtacg ccgcatcacc gccggcctga
    14521 caccagctgt gctggtggag cgtggtctcc tcgaagcgat ccggattctg gcgcaccggt
    14581 tgagtaccga ggtggttcag gtggtcgtgg ccgatcccgc gacgaagatg cctgttctgg
    14641 cccccgcggt ggagacggcc gcctaccgca tcgccgccga ggcgatgacc aacgccgtgc
    14701 gtcattcggg agcccgccgc gtactcgtcg gcctggctgt cacacccgcg tcgctgaccg
    14761 tcaaggtcag tgacgacggc aacggtctgc ccggcggggg cgtaccgggt acgggcctcg
    14821 cctcgttcac agagcgggcc gaggagatcg gcggcacgac tggcgtccac acgggccctc
    14881 atggcaccgc cgtgcacgcc accttgcccc tcacccggca gggccgagaa cttgaggagg
    14941 gtcatgagcg cccagaacga cgcggaccgg caggatcatg cggcaccggc accggcaccg
    15001 gcaccggctc ggcgagtact gctggtggat gaccaccccc tgttccggga aggcctcgca
    15061 gccgcgatcg acctggatga ccacttcacc gtggtcgcgg aggcggccag cggcgaagcg
    15121 gcactcaccg aaaccgcacg caccgatccc gacctggtgg tcatggacct ctgccttccc
    15181 ggtatctcgg gcatcgaggc cacacgccga ctgctcacgg cccacccaca ccttcgcatc
    15241 atggtgatga cgatgtccga ggacgacgac agcctcctcg cggcgatgcg cgccggtgct
    15301 catggctacc tcctgaaggg agctctgcgt gaggaagtcc tacgcgccct gcacacggtc
    15361 gcgcggggcg gagcggtctt cggcccgcag atgacggaac ggttgagcgc actgttcgct
    15421 gctttcggcc gcacaccggc gaaggaggcg ttcccgacgc tcacggcccg agaacgcgac
    15481 atcctcgatc tgctcgcggc cggcctcacc taccgacaga tcgcgcagcg gctctgcgtg
    15541 gtggagaaga ccgtgcgcaa tcacgtcggt gccatcttct ccaagctcca agtccacgac
    15601 cgtgccgcgg cgatcgtccg ggcccgcgac gcgggccttg gaccgcaacc gcagtgaaga
    15661 cccggtgacg gcggtcggta cttcccagcc gtccacccgg ccgtcgacag tggtgctgga
    15721 cgcggtgaag ctcgtcgacg cggacggtca gccacaccgg tcagggacgc gacagcgcac
    15781 caccttccac cggtgaaggc ggctggggag cagcagccag acagccgacg ggcttcagcg
    15841 gggcacccaa ggcaggccgg gtcggcctcc ccgagccagc acaatcaggg ctactgaggg
    15901 aggcggcgtc gaaagcgagc atgcgccggg cgggagtctc cggatagccg tgaccggctg
    15961 agaaccggcc gccccagagt cttgcggtat gccccctccc gggctcctga tggatactcg
    16021 gcgttccctg gtcctgccgg ggccgcaggt cgaaggagcc gggggaggct attggccgac
    16081 cacgccccgt tccgcgagtg ttgtgcgcag ggcgcgtatg gcgtagaagg cgcggctttt
    16141 gacggtgccg ggtgggatac cgaggtattc ggcggcctgg gccacgctgc attccatgta
    16201 gtacatgagg tgaatgacgg ctcgttgctg ttcgttgagt tccttcagcg cttcgaggat
    16261 cacgtgggag gtgagcgtgg tctccaagcc gtcccaaacg gcgtccagct cttgggcagg
    16321 gacctgttcc aaggggcggc atcggcgggc gcgatggtgg tcgatgacca ggttcttgac
    16381 cacggtgtac agccacggcc ggacatgttc gcggcgggcg cccaggaacc gggcgtgctt
    16441 ccaggcgcgg gtcgcggctt cctggatcat gtcctccgcc ctgtgccagt cgccgtccag
    16501 cagccgtgtg gcgtatcgga cgagcaaggg accgtactgg tcgtagatct cttcgatgaa
    16561 ggcgtcgcag tcgacgtccg atgagatgtg ccgggcccgc atccgggcgg gggcggaggt
    16621 ggtgaccctt gcgtccaagg tcccgttcat aggtggcgct cgatcctgtt cacgtgttct
    16681 gtggcgtgcc cccacacgag cgggagcgtg gggccaacac tgtgcggacc gccttggcga
    16741 aaccttttcg tcttcttgtc gccgtccctt gtcactcctg ccgcggccct gaccgggtca
    16801 gaccccaccg gcctcggcgt cccgctgatc ccggtccgtg caacacgggt gaaccggacc
    16861 tggcctcgga acgtaggaga cgaagaaggc gccgtcagcg aggcctttgg ccccggagag
    16921 cggtatgagg accggaactg ttcagcctgg caaccacctc tggccgcgcc ccggtgcgcc
    16981 ccggtgcgcc ccggtgcgtt tcggtgtggt ccccacacag ctcatcagcg ccttgccacc
    17041 cacgacagac aacccaagga agaggacttc cacgatgcgc tccacccgcc cgagccgccg
    17101 gaccaccctt gccggtctca ccgccctcgc ggccctgtcc accgtgaccg tcgccctccc
    17161 cggggcggcg ggagcctcgc cccgccacaa ggcgctgccg acgatcgtgc tggagcacgg
    17221 ggcgttcgcc gatgccgcga gctgggacgg cgtcgtcaag cggctgcagc ggtccggcta
    17281 cccggtggtg gccgccgcga acccgctgcg cggcccggcg aacgacgccg cctacctgcg
    17341 cagcgtggtc gatcacatcg acgggcccgt ggtcctggtc ggccactcct acggcggcac
    17401 cgtcatcagc caggccgcgg ccggactgga ggacaaggtg aaggcgctcg tctacatcgc
    17461 ggcgttcctg cccgacgcgg gcgagagttc gctggggctg accgacaagt tcccgggcag
    17521 caccctcggt caggtcatcg agccggtgaa ctacacgctg ccggacggcg gccaaggggc
    17581 cgacgtgtac atcaagccgg agaagttccg caagcagttc gccgcggacg tgccggcgga
    17641 caaggcgcgg ctcatggccg ccggacagcg tccggtggcc gcggccgcgc tggaggagaa
    17701 gtccacgacg gccgcctgga aggccatccc ctcctggtcg ctggtcacca ccaaggaccg
    17761 gaacatcccc gtggccgccc agcgcttcat gtcggcccgg gcgcacgcgc acacgaccga
    17821 gatcgacgcc tcccacgcgg tgaccgtctc acgccccgac gccgtcaccc ggatcgtcga
    17881 gaaggccgcc cgcacggccc gctgaccaca ccccgcatcc atccccttat tcacacctat
    17941 acaccccata cacggcacta cccctcatat aggaaggaag cggcatcatg gcattcatca
    18001 ccgtcggcca ggagaactcc acctccatcg acctctacta cgaggaccac ggcaccgggc
    18061 agccggtcgt gctgatccac ggctatccgc tcgacggcca gtcctgggag aagcaggccg
    18121 cagccctgct gaaggccggc taccgcgtca tcacctacga ccgccgcggc ttcggccgtt
    18181 ccagccggcc caccaacggc tacgactacg acaccttcgc cgccgacctc aacaccgtcc
    18241 tggagaccct cgacctccac gacgccgtcc tggtcggatt ctccatgggt accggcgaag
    18301 tcggccgcta cttgggcact tacgggtccg cccggatcgc cagggccgcc ttcctcgcct
    18361 ccctcgaacc gttcctgctc aagaccgacg acaaccccga gggggtcgac ggcagtgtct
    18421 tcgagggcat cgaacaggcc gtcaccgccg accggtacgc ctacttcacc gcgttctgcg
    18481 aggacttcta caacctcgac gagaacctcg gcacccggat cagcgaggag gccgtacgca
    18541 acagctggaa caccgccgcg ggcgcctcct ggtacgcctc gctggcctgc gtggcgacct
    18601 ggacgaccga cttccgcgcc gacgtcgccg cgatcgacgt acccgcgctg atcctgcacg
    18661 gcaccgccga tcgcatcctc ccgatcgagg ccaccggaga acccttccac cgggcccttc
    18721 cgcaggccga gtacgtggtc atcgagggcg ccccgcacgg tctgctgtgg acccacgccc
    18781 aggaagtcac cgacgccctg ctcgccttcc tggccacgtg acccacacca gggcggccgc
    18841 tccgcggctc cggcggagcg gccgccctgg caacgaacgc ccgcgccatc ggatcggctc
    18901 cgggagatcc gctagacctg cctcgagaca ggcacgggaa ccttgtgcgc aggggcgccg
    18961 ctcgccggag ccggggcgcg ggcgtctccg gcggactccg ccgacgcggc gggatcgagg
    19021 ggcatctcgc tgtccagagc ggccagccgc tccctgacct cctgggcgct gcgggacagt
    19081 gcgtgttgtt cggcgccggc gagggcccgg gtccattcag cccgggcagc ctccgagtcg
    19141 cccatggcca gacgtgtgtc acccaggcgc atcagcgcgc cgacggcatt ccgctggtca
    19201 cccagttcct cgaaggcttc caccgcctgc cggtaggtgg tcaccgattc ctcgtaccgg
    19261 ccgagctgac ggaggatgtg gcccagaacg tcccagttct gggcctgctg ccagggggcg
    19321 tccagaagct ggaacaggga catggcctcc tggctcagcg tgaggccctt ctcgtgctgc
    19381 cccaggttgg agtggaacca ggcaagctcg acgaggcatt cggcggtcca gagctggtcc
    19441 cctgtcgccc gggacagggc gagcccccgc tcggaagcca ccaccgcctc cggggtccgg
    19501 ccgaacaggt gcagggcgca cgccagggcg tagtgggcgc gggcctgctc gcccacggcg
    19561 ccgagttcat cgagaatcgt gatggcgcgg ttcaggtggc acagggcctg ttcctcgtga
    19621 ccgaggtagc cgtggatgcc accgatgtgg cgcaggcagc ggccttcttc gaggcggtcg
    19681 ccccggcgcc gggccacgtc cagggcggga gtcaacgcgg tgatggcttc cggccagtac
    19741 tcctggcggt tgaggtactc cttcagcgac caggcgaggc cggtgatgtg gtggtccatc
    19801 ctctggccga cggcggtgtg cagcagggcg gccagtaccc ggtgctcggc ggcgaaccac
    19861 cggttcgcct gccccacggt ggtgagatcc tccggggtga cgtccgcgct cggtgagccg
    19921 aggtcgagtt cgggcagtga gtcctgcttg aacagccggt tgccttggta ggccgtgaac
    19981 atgtaatggt caaggacccg cagggtggcg tggtgacgct cgctggtgtc gtcgtgggtg
    20041 tgggtgagct cggtggcgta gccgcgcagc aggtcgtgca gggcgtaccg gcctggcagt
    20101 ggttgttcga cgaggcagga gcgggtgagt acggagagca ggcgttgggc ccgggggaga
    20161 gggagcccag cgaggccggc ggcagccgcg gcggtgatgt cgggcccggg atggagggcc
    20221 aggagccgga agagccgtgc gacggcctcg tccagggacc ggtaggacca ggagaacacg
    20281 ctccggacat cagtggtgtc gtcgaatccg gtgaacgcct ccaagccacc gtgggcatgg
    20341 cgcaggtcat cggcgactgc gtgcaggggg aacgtcgggt cgagttcggc gcgagcggcc
    20401 actacggcga gtgccagggg gagacgtccg cacagctgga tgatgtcggc cgtggcggcg
    20461 ggctcggcgt ccaggcgttc ggcccccaac cgccgtgtca gcgtctcgtg agcctctgcc
    20521 tgtgagggca gcgcgagggt gagggtcttg gccccttcgg tcgctatcag gcccgggagc
    20581 cggttgcggc tggtgaccag ggtgaggcag ccgccgcctg cgggcagcag gggtcggacc
    20641 tgctgttcgt cgcgggcgtt gtccaggacg aggaggaccc gccggccggc caggaggctg
    20701 cggaacagcg tgctgcggcc gtcggtgtcc tcggggatgc gctgggcggg gacgccgagc
    20761 gcggtgagga agccgtgcag ggcgtcgccg ggctccacgg cgggtgcggt cggatggaac
    20821 ccgcagaggt tgacgaagag ctgtccgtcg gggaaggagg aggcgatgcg gtgggcgtgg
    20881 tggacggcga aggtggtctt gccgactccc ggggcgccgc cgatgacgac gacgggagcg
    20941 ccggacggcg ccggccggcc gggcgcaccg ttcacggcgg acagccaggc gctctcggcc
    21001 gcccggcccg cgaacaccgg caggtcccgt ggcagttgtg ccgggcgcac cggccggatg
    21061 tcctccgcgc cactgtctcc cggccggtgg ccgtgagcat cggccggacc tgccggaccg
    21121 gcggatgccc cggcgaccgt gccggccggg gacgcctcgc cggccggccc gcgggccacg
    21181 gcatcaccgg agatgtcact ggggtcggca tctgggcctg tggcggcagc aggtcgtgca
    21241 ccggcaggtc ctgtgacgtc ctggcccccg ggagaggccg cgggcttgcc gtcggatgcc
    21301 gcaggcgcag ccgggtgccc cggacagccg cggtctgcgg tgcgggccgg ctgtcccgcc
    21361 gttcccggca gaggcagggg cggcagctca tggcggagga tgccctcgtg cagggcacgc
    21421 agcgcggggc cgggttcgag gccgaggccg tcggcgaggc gccggcgcag atccgcgtag
    21481 tgccccagtg cctcggggtg tctgccggcc agatacagcg cacgcagcag cagggcccag
    21541 ccggtctccc gcagcgggtg ctctctcgtc agctcctgtg ccgcgtcgac ggcctcgggc
    21601 agccgtccgc tcaggagcag ggcggtggtg cgggtctccc ggacggtctg ccgcagttcc
    21661 tccagccgcg cgctctcgtg ggcggcgaac aggtgatgtg cggcatcggc gagtgcggca
    21721 ccacgccaca tccccagagc ccggtcggtc tcccgcagca cgtgttcggg ctgtccctgg
    21781 cccaacagct ggtgcgctcg ggcggccgtc cgctcgaagc gcacggtgtc cctgctctcg
    21841 ggcgggacgc gcagggcgta gccggcgggc tcggtgacca ggaccgcgaa cgtcccccgc
    21901 acgcgcaggt gctgcggctc caggaccgcg cggaccttgc tgacatgggc gtgcagggag
    21961 gccatcgccc cgcccggcgc gcgacccgcc tcctccgccc acaggtcctc gcacagggtc
    22021 tggggagtga ccgcacagcc gtccgcgagc agcagtcgta ccaggagcag ccgctgcttg
    22081 cgccgccccg gatcaaggac ctcgcccgcc cgcctcacca ccagcgggcc cagcagcccg
    22141 aagtcgagtt cctgccccaa agccctcacc catcccaccc agtaccttgc tcaacattct
    22201 cgccgcctct ccgcgcacga cggcacgcgg tcactgtcgc ggcgcccctc ccgggcctgg
    22261 ggaggggaaa gcggcacggg tcgtccgaag cggggagaac cctctcgcgt ccccccgggg
    22321 gcgcgaggta cgggtaacgg gtccgctccg gccgaccgct ggggtcgtga ccgtcgtgac
    22381 ccatacccct tgacttcgtg cggcgggtgc cgtgcaagcg taaccgtgtg cccggctccg
    22441 ggcgtacggg cccatgatcg atcacgcacc gcgactcgcc ggggatcagg gccggtgtgg
    22501 ctgctggtcg cc
//
