LOCUS       NZ_CP015588            22187 bp    DNA     linear   CON 05-MAR-2024
DEFINITION  Streptomyces alfalfae strain ACCC40021 chromosome, complete genome.
ACCESSION   NZ_CP015588
VERSION     NZ_CP015588.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces alfalfae
  ORGANISM  Streptomyces alfalfae
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8625867)
  AUTHORS   Gu,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-MAY-2016) Institute of Agricultural Resources and
            Regional Planning, Chinese Agricultural Academy of Sciences, 12
            Zhong Guan Cun South Street, Beijing 100081, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: SOAPdenovo v. 2.04; Celera Assembler v. 8.0;
            GapCloser v. 1.12
            Genome Coverage                   :: 310.8
            Sequencing Technology             :: Illumina; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 02:19:30
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,535
            CDSs (total)                      :: 7,444
            Genes (coding)                    :: 7,210
            CDSs (with protein)               :: 7,210
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 234
            CDSs (without protein)            :: 234
            Pseudo Genes (ambiguous residues) :: 0 of 234
            Pseudo Genes (frameshifted)       :: 107 of 234
            Pseudo Genes (incomplete)         :: 177 of 234
            Pseudo Genes (internal stop)      :: 26 of 234
            Pseudo Genes (multiple problems)  :: 73 of 234
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:53:12
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2298855
            Orig. end                         :: 2321042
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP015588.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22187
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="16"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22187
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22187
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12187](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12187)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(444..459)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.11"
                     /tool="antismash"
     gene            complement(817..1443)
                     /locus_tag="A7J05_RS09595"
                     /old_locus_tag="A7J05_09210"
     CDS             complement(817..1443)
                     /EC_number="5.4.99.61"
                     /GO_function="GO:0016993 - precorrin-8X methylmutase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015578014.1"
                     /locus_tag="A7J05_RS09595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7J05_09210"
                     /product="precorrin-8X methylmutase"
                     /protein_id="WP_103557396.1"
                     /transl_table=11
                     /translation="MFDYEKDGAAIYRESFATIRAEADLAGLPADVSQVAVRMIHACGM
                     VDLVRDLAFSPRVIADARKALRDGAPILCDANMVASGVTRKRLPADNEVVCTLADPAVP
                     DLAAQLATTRSAAALELWRDRLEGSVVAIGNAPTALFRLLEMIEAGAPRPAAVLGIPVG
                     FVGAAESKDALAEHSSGLEYLVVRGRRGGSAMAAAAINAIASEAE"
     gene            complement(1455..2741)
                     /gene="cobG"
                     /locus_tag="A7J05_RS09600"
                     /old_locus_tag="A7J05_09215"
     CDS             complement(1455..2741)
                     /EC_number="1.14.13.83"
                     /GO_function="GO:0016709 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen, NAD(P)H as one donor, and incorporation
                     of one atom of oxygen [Evidence IEA]"
                     /GO_process="GO:0019250 - aerobic cobalamin biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="cobG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007267283.1"
                     /locus_tag="A7J05_RS09600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7J05_09215"
                     /product="precorrin-3B synthase"
                     /protein_id="WP_076684078.1"
                     /transl_table=11
                     /translation="MLAAMPPTRATSTNKGESLIRDRGDACPGALRPHLADDGALVRLR
                     LPAGLLTGHQAAVLADAAERLADGALSVTSRGNVELRGLADGCVSALAALLTDAGLLPS
                     GRHERIRNIVASPLAGLDGLGRADVQLWARELDGLLCAREWTAALSGRFLFALDDGRGD
                     MAGLGGDVTLIAESDGTAVVRAGGPALRVAAADAPRAALAAAGAFLAAAREAGNGAWRV
                     RELPDGRRVDLAAALEEAGVAATPAEPSTAPRATPHPPGVTGRAVAVSAPLGRVTAAQW
                     RALLPLPADELRVTPWRGFVLPGFADAGAARDRLAALAGAGFLTDPASPWLGVGACTGR
                     PGCAKSLADVRADAVPGLGGLPVHWSGCERRCGHPRGDWVDVLATGDGRYEVTVRTSGG
                     HGTPVRGGTLTEAVSTARTTSATTPTATK"
     regulatory      2891..2963
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            3020..6625
                     /gene="cobN"
                     /locus_tag="A7J05_RS09605"
                     /old_locus_tag="A7J05_09220"
     CDS             3020..6625
                     /EC_number="6.6.1.2"
                     /GO_function="GO:0051116 - cobaltochelatase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cobN"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1263: cobaltochelatase subunit CobN"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008744494.1"
                     /locus_tag="A7J05_RS09605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7J05_09220"
                     /product="cobaltochelatase subunit CobN"
                     /protein_id="WP_076684079.1"
                     /transl_table=11
                     /translation="MLLLLSTSDTDLLSARAAGGPVDYRFANPSRLDLAELPALLDGAD
                     LVVVRLLGGVRAWQDGLDQLTASGLPVVVLTGEQAPDAQLMASSTVPVGIAAEAHAYLA
                     HGGPANLEQLARFLSDTVLLTGHGFEPPAPAPSWGPLERAARDVAGPTVAVLYYRAHHM
                     SGNTAFVDALCGAIEDAGARPLPLYVASLRAPEPELIEELRAADAIVTTVLAAGGTKPA
                     EASAGGDDESWDAGALTGLDVPILQALCLTGSRSAWEENDEGVSPLDAASQIAVPEFDG
                     RLITVPFSFKEIDEDGLPAYVADAERAARVAGIAVRHARLRHIPAADKRLALVLSAYPT
                     KHSRIGNAVGLDTPASAVALLRRLIDEGYDFGPAEEIPGLVSGDGDELIRALIDAGGHD
                     QDWLTDEQLAANPVRIPAAAYKRWYATLPQELRESVEEHWGPPPGEMFLDRSRVADGGD
                     PEGDIVLAALRRGNLLILIQPPRGFGQNPIAIYHDPDLPPSHHYLAAYRWIAASADDGG
                     FGADAMVHLGKHGNLEWLPGKNAGLSAACGPDAALGDLPLVYPFLVNDPGEGTQAKRRV
                     HATLIDHLVPPMDRADSYGDIARLEQLLDEYAQISSMDPAKLPAIRAQIWTLIQAAKLD
                     HDLGLEDRPDDDGFDDFLLHVDGWLCEIKDMQIRDGLHVLGSAPAGAARVNLVLAILRA
                     RQIWGGASALPGLREALGLDESAATRASADEAEEKARALVQAMDDADWDLSAVPADQSE
                     QVRAILEFAAREVVPRLAATTAELDHSVHALNGGFVPAGPSGSPLRGLVNVLPTGRNFY
                     SVDPKAVPSRLAWETGQALADSLIERYRTDNGDYPTSVGLSLWGTSAMRTAGDDVAEAM
                     ALLGVRPVWDDASRRVTGLEAIPYEELGRPRIDVTLRISGFFRDAFPHTIGLLDDAVRL
                     AASLEEPAEQNHVRAHAQADLAEHGDERRATTRIFGSRPGTYGAGLLQLIDSRDWRTDA
                     DLAEVYTVWGGYAYGRGLEGRPARAEMETAYKRIAVAAKNTDTREHDIADSDDYFQYHG
                     GMVATVRALRGTAPEAYIGDSTRPETVRTRTLVEETSRVFRARVVNPKWIEAMRRHGYK
                     GAFELAATVDYLFGYDATTGVVADWMYDKLTETYVLDPTNRQFLQEANPWALHGIAERL
                     LEAESRGMWAKPDPAVLEALRQAYLETEGNLEDEG"
     gene            complement(6635..7906)
                     /locus_tag="A7J05_RS09610"
                     /old_locus_tag="A7J05_09225"
     CDS             complement(6635..7906)
                     /GO_function="GO:0004180 - carboxypeptidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1244: amidohydrolase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016572954.1"
                     /locus_tag="A7J05_RS09610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7J05_09225"
                     /product="amidohydrolase"
                     /protein_id="WP_076684080.1"
                     /transl_table=11
                     /translation="MSDDPARDRTPAAPAALAGLDALQGDLADLYRHLHAHPEPSFEEH
                     RTAAEAARRAASYGYEVTTGVGRTGVVAVLANGEGPAVLLRADMDALPVTEATGLPYAS
                     RTEGVMHACGHDMHVTCLLGALKLLADSRDAWSGRVVAVFQPAEEAGQGARVMVADRFY
                     ERFGTPDVVLGQHVAPLPAGMVGAHAGPAFAATDALRVRMFGKGGHGSRPEATVDPVVM
                     AASTVMRLQTVVSREVAGGETAVVTVGVLRAGAKHNVIPDEAELQLNIRTYTPEVRTRV
                     LAAVERIIKGEAATAGAEREPEITEIDTFPVVVNDAHAVDRTMAAVGAVIGAERVMDPG
                     QVTGSEDVGHFATSAEPEVPLCYWLLGGADPAKVIAAQRAGTFERDIPSNHSPFFAPLI
                     EPTITTGVTALTTAALAWLGGPRR"
     gene            8046..8525
                     /locus_tag="A7J05_RS09615"
                     /old_locus_tag="A7J05_09230"
     CDS             8046..8525
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014045198.1"
                     /locus_tag="A7J05_RS09615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7J05_09230"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_076684081.1"
                     /transl_table=11
                     /translation="MTERRIPSPADPDAADAALVSQPIGYWSGAVHRAVTRRIRDAMAR
                     MDVTQPQWWTLNRVAADPGPTRETVAAQLAEVADGPYEIPRVVDQLLHRGWLLVDPEQR
                     LFVTDEGREAMGRVTGLVTSLRAEVHDGVSDEDYVTTLRVLRTMLGNLDGGKQRA"
     gene            complement(8579..9949)
                     /locus_tag="A7J05_RS09620"
                     /old_locus_tag="A7J05_09235"
     CDS             complement(8579..9949)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000060: Oxidation (75% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014133527.1"
                     /locus_tag="A7J05_RS09620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7J05_09235"
                     /product="cytochrome P450"
                     /protein_id="WP_076684082.1"
                     /sec_met_domain="p450 (E-value: 3.8e-77, bitscore: 258.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQQTAQPEQQTFVAGTAPGAAPLVGHAWQMMRRPLQFMSSLSRH
                     GDLVKIRLGPTEAHVPTHPALLRQVLTSDNEYDKGGIFYDRARDIAGNGLVTCPYADHR
                     RQRRLMQSAFTRPQLKRYASAMHAEIETTAERWSDGAVVDAFPEMYGMALRTVGRTLYS
                     TPVSKELADSVERAFDAVLKGLFRQMFLPAAVRRMPSPGNRRYRANLDYLHRTTQTLID
                     DYRRDGADHDDLLSALLDSRDEDGGRLGDKEIHDQVITVMAAGTETVAATLTWIFYLLS
                     KYPRIEKALYAEIDEVLGGRAPEFDDVARLQLTDRIITETLRLYPPAWLFTRLTATDLD
                     VAGLRLPAGSTVVFSPAAVALDAGSFPHERRFDPDRWLPDRVTPQARQSFMAFGTGARK
                     CIGDLYARTEATLALATILSTWRVTCEPGVDVRPVPLATVYQPRRLRLRLTARTPGA"
     gene            complement(10001..11011)
                     /locus_tag="A7J05_RS09625"
                     /old_locus_tag="A7J05_09240"
     CDS             complement(10001..11011)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358321.1"
                     /locus_tag="A7J05_RS09625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7J05_09240"
                     /product="pentalenene synthase"
                     /protein_id="WP_076684083.1"
                     /sec_met_domain="T1TS (E-value: 4.9e-79, bitscore: 265.5,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPQDVDFSIPLPGRRSPDHARAEAAHIEWPRSFGLISSEAAAERH
                     RKGGYADLASRFYPSTTGADLDLGVDLMSWFFLFDDLFDGPRGEDPEQARQLTDAVAAA
                     LDGPLPASAPLIAHGFADVWRRTCQGMSKEWCTRSAQHWRHYFQGYVDEAHGRLDETPC
                     GSAREYLAMRRHTIGVQPTIDLAEATGHFEVPHRVFDGAVMSAMLRIAVDVNLMLNDIA
                     SLEKEEARGELNNMVFILMREHGWTRSRSIAHMQDEVGVRLEEFLLLESILPKVCDAFS
                     LTADEREAVERYRLDAVRPVIRGSYDWHRSSGRYDAEFALAAGRQGFLEELGSAR"
     gene            complement(11174..12187)
                     /locus_tag="A7J05_RS09630"
                     /old_locus_tag="A7J05_09245"
     CDS             complement(11174..12187)
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358322.1"
                     /locus_tag="A7J05_RS09630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7J05_09245"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_076684084.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 7e-61, bitscore:
                     204.6, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTAPACLSHSRVTITPALRAAVDRLDHRSRHQAAYHFGWITAGG
                     APTSADAGKAVRPALALLSAEAVGAPPEVALPGAVAVELVHNFSLVHDDLMDGDEERRH
                     RRTVWKLWGPSSAILTGDAMLALAQEVLLDTGLPTAAPAARLLARTTRHLIRGQVQDLS
                     FEQRGHVTVEECLDMAAGKTGALLSASAAIGAVLAGAPEATVDALALYGDHVGIAFQLV
                     DDVLGIWGDPAVTGKSAHSDLRSRKKTLPVSHALHQDGPLSAELAAWLATRGEPGEEEL
                     RRAAALVEGAGGRDWALAEAARRMALAEAALRGVDLDAGARDELLALGRFVVDREG"
     gene            complement(12184..13083)
                     /locus_tag="A7J05_RS09635"
                     /old_locus_tag="A7J05_09250"
     CDS             complement(12184..13083)
                     /EC_number="1.14.11.-"
                     /GO_function="GO:0051213 - dioxygenase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: TauD (4-281). E-value: 2.9e-53. Score:
                     173.3. Matches aSDomain:
                     nrpspksdomains_A7J05_RS09635_TauD.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000058: Dehydration, Oxidation (86% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1121: dioxygenase, TauD/TfdA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014182242.1"
                     /locus_tag="A7J05_RS09635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7J05_09250"
                     /product="TauD/TfdA family dioxygenase"
                     /protein_id="WP_076684085.1"
                     /sec_met_domain="TauD (E-value: 3.6e-51, bitscore: 173.3,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVTPIPGAALGAVVDGAHVSGDMDEAQANEIWAALDAHLVLVFR
                     GHETPTYEEFLAFGRRFGHIPKTGLTSGAHPDHNEILIVSNLVEDGRKIGVGDAGWMGW
                     HTDYSFRPRVSQVGFLEAVEVPPSGGGETLFTDMYALYESLPAEERRRLHSYRVRHALR
                     TGYEETIEEELQGEVSLGEDPRRIRAEDGTSTVHPLVARNPRTGRRSVYVSTLNTERIV
                     DLAPDAGRELLDKLLAHAGTPRHTYAHTWRPGDIVMWDQLGTVHAKRAFDPAERRVMRQ
                     VVSIFDDPTAPWRAEAAA"
     aSDomain        complement(12241..13071)
                     /aSDomain="TauD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A7J05_RS09635_TauD.1"
                     /evalue="2.90E-53"
                     /label="A7J05_RS09635_TauD.1"
                     /locus_tag="A7J05_RS09635"
                     /protein_end="281"
                     /protein_start="4"
                     /score="173.3"
                     /tool="antismash"
                     /translation="PIPGAALGAVVDGAHVSGDMDEAQANEIWAALDAHLVLVFRGHET
                     PTYEEFLAFGRRFGHIPKTGLTSGAHPDHNEILIVSNLVEDGRKIGVGDAGWMGWHTDY
                     SFRPRVSQVGFLEAVEVPPSGGGETLFTDMYALYESLPAEERRRLHSYRVRHALRTGYE
                     ETIEEELQGEVSLGEDPRRIRAEDGTSTVHPLVARNPRTGRRSVYVSTLNTERIVDLAP
                     DAGRELLDKLLAHAGTPRHTYAHTWRPGDIVMWDQLGTVHAKRAFDPAERRVMRQ"
     gene            complement(13118..14872)
                     /locus_tag="A7J05_RS09640"
                     /old_locus_tag="A7J05_09255"
     CDS             complement(13118..14872)
                     /EC_number="1.14.13.-"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000057: Oxidation (93% identity)"
                     /gene_functions="other (smcogs) SMCOG1092: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014182241.1"
                     /locus_tag="A7J05_RS09640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7J05_09255"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_076688792.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 2.9e-07, bitscore:
                     28.8, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MREKYRQERDKRGAGRTYQFARGDFSHYARDPYTERREREPLTDE
                     VDVAVVGAGIGGLLTGANLRKETGLDRIRLIDEAGDVGGTWYWNRFPGVRCDVESYIYM
                     PLLEETGTIPTEKYSTGPEIFAHLQRIAREYDLYRDALFQTTVTELRWDEAAARWLVST
                     DRGDVIRARYVAMSIGLMHRPKLPGLPGLDAFAGHSFHASRWDFDYTGGDSTGGLTGLR
                     DKRVGVIGTGSTTIQLAPHLAEWAKELVLFQRTPATVDVRGNRPTPPGWAESLEPGWQQ
                     RRMENFHALTSGIPQDEDLVQDRWTQTTAKLAAAILPTGDTGGDPKERALAAERADFLK
                     MEELRARIDSVVTDPATAAALKPYYRVYCKRPCFHDGYLQTFNRPNVTLVDTQGQGVER
                     LTPAGVVANGREYPVDCLIFATGYEHEFAVPYTERAGYDIVGRGGTRLSEKWADGARTL
                     HGLQVNGFPNCFILSKVQAGRHVNIAYMLGEQTRHLAHIVKCVEERGHRVVEASEAGEK
                     EWVEEILRLASSDLDFLENCTPGLYNNEGDPGGLPLLNSSYGGGSVEFVNILRRWREAG
                     DLAGLDLR"
     gene            complement(14935..15762)
                     /locus_tag="A7J05_RS09645"
                     /old_locus_tag="A7J05_09260"
     CDS             complement(14935..15762)
                     /NRPS_PKS="Domain: PKS_KR (6-174). E-value: 6e-13. Score:
                     41.0. Matches aSDomain:
                     nrpspksdomains_A7J05_RS09645_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014182240.1"
                     /locus_tag="A7J05_RS09645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7J05_09260"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_076684086.1"
                     /sec_met_domain="adh_short (E-value: 1.5e-29, bitscore:
                     102.1, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHSQTQTAVVTGAASGIGLALSARLARAGASVIMADVEGGALRRR
                     AAELTAQGGQVTAVTADLTDPDAVERLADTAFDVLGDIDVVCNNAGVLGPVGQPLWEAP
                     LERMREVFEVNHWAHVLVARAFVPRLLARGRPAHLVHTASMSAFVVGAGSAAYAASKHA
                     DLAVARSLRADLADTGIRVSVLCPGRVDTPMVQGLTAPRGAGGDTSVSAEAVAGVVVDA
                     LGSDRFYLFSNSDAPQRLRDQFDDVWRHVSLSPPSPEEELWPAPKATTGATKH"
     aSDomain        complement(15241..15744)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A7J05_RS09645_PKS_KR.1"
                     /evalue="6.00E-13"
                     /label="A7J05_RS09645_PKS_KR.1"
                     /locus_tag="A7J05_RS09645"
                     /protein_end="174"
                     /protein_start="6"
                     /score="41.0"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TAVVTGAASGIGLALSARLARAGASVIMADVEGGALRRRAAELTA
                     QGGQVTAVTADLTDPDAVERLADTAFDVLGDIDVVCNNAGVLGPVGQPLWEAPLERMRE
                     VFEVNHWAHVLVARAFVPRLLARGRPAHLVHTASMSAFVVGAGSAAYAASKHADLAVAR
                     SLRAD"
     CDS_motif       complement(15286..15351)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A7J05_RS09645_0002"
                     /evalue="1.20E-02"
                     /label="PKSI-KR_m4"
                     /locus_tag="A7J05_RS09645"
                     /protein_end="159"
                     /protein_start="137"
                     /score="8.2"
                     /tool="antismash"
                     /translation="HLVHTASMSAFVVGAGSAAYAA"
     CDS_motif       complement(15673..15738)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A7J05_RS09645_0001"
                     /evalue="4.60E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="A7J05_RS09645"
                     /protein_end="30"
                     /protein_start="8"
                     /score="16.1"
                     /tool="antismash"
                     /translation="VVTGAASGIGLALSARLARAGA"
     gene            complement(15864..17318)
                     /locus_tag="A7J05_RS09650"
                     /old_locus_tag="A7J05_09265"
     CDS             complement(15864..17318)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358326.1"
                     /locus_tag="A7J05_RS09650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7J05_09265"
                     /product="MFS transporter"
                     /protein_id="WP_076684087.1"
                     /transl_table=11
                     /translation="MTQREGLPSPQGPTAAPEPPAGPRPAATGLSGIALVVVLTGYALS
                     IVDASIVNVALNPISDDLHGGPAALELVVSGYGLTYALGLVLGGRLGDAFGRQRLYAYG
                     LAAFTLTSALCGLAPTIEFLVAARLLQGAAAAMLVPQVLATIQAATEGQARARAIGMYG
                     ATAALGMVIGQILGGLLVSLDIAGIGWRAVFAINVPIGVAALLAVRRVPATKADAKPSF
                     DPRGTALFGLTMVCVLALVVAGPELGWPPWLWSLLLVAAAGAVALARVERGLEARGGSP
                     LLSPSVLSHQGMRRGLAAMVPFSAGFGAFLFVYALVAQGHFGFDGLESGGGLAPFAVAF
                     FAVTLFTPRIAAALGARIVTLGAFVQGAGLLLLALVIRLGWPHPSLTLVLVGIGLYGVG
                     AALTGPTLFRMILADVPPAQAGMGSGVLVTSQQMATALGATVGGTVYLSLADWQSTVSA
                     AVGVLALLACCSVTVLVISLKLPDPR"
     gene            complement(17377..18237)
                     /locus_tag="A7J05_RS09655"
                     /old_locus_tag="A7J05_09270"
     CDS             complement(17377..18237)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_037648981.1"
                     /locus_tag="A7J05_RS09655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7J05_09270"
                     /product="phytanoyl-CoA dioxygenase family protein"
                     /protein_id="WP_076684088.1"
                     /sec_met_domain="PhyH (E-value: 3e-17, bitscore: 62.3,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDTFSDYADCTPLIDDREALDRFYDEHGYLYLRGVLDRDLVRTA
                     AEQMLEGLIALGHAAPGTTLETLTIESFEAVDEVAMHDYVKYDDLWNHPSTLKVWEKAF
                     GEPVFVFKSTTIRYYPSAAGAAGSEEPHFLTPLHQDGFYIGPNKDFRTAWIPLLPTTPG
                     TGGVALADGSHKKGPREHVVTENFRRFGHPVRGIPAEEFGADERLLFSPMEPGDVLLFH
                     AYMCHKSIPNVSADPAAMRMSMDTRVQPATSHRGFNSLTPWPESAKDASKGILSKITGT
                     PTTIE"
     gene            complement(18332..19528)
                     /locus_tag="A7J05_RS09660"
                     /old_locus_tag="A7J05_09275"
     CDS             complement(18332..19528)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000059: Other (85% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014182237.1"
                     /locus_tag="A7J05_RS09660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7J05_09275"
                     /product="cytochrome P450"
                     /protein_id="WP_076684089.1"
                     /sec_met_domain="p450 (E-value: 3.2e-17, bitscore: 61.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTELPRLPFDNPSIMGIAPQMRALQREGPIARVRTAGEDAWLVTR
                     YDEVRTLLADPRLRLSNPDPEQSANSAARGFMVALMAGDDCATEPARHAQMRALLVPLF
                     STRRMRRMQTRIERHVDELLDQLAVSAPPVDLHRALSFPLPTMVVCDLLGVPLDDRERF
                     GQYARGTFDHSDDQHSANTFKKVVDYLRELVARKRTEPGDDILSELISAKDGALSDEEI
                     VQLGAAVLLFGYETTIVRIDLGTLLLFRNPAQRAQLVEDPGLAPAAVEEILRLGVGGKG
                     SNALIPRYAHSDITVGDTVIRAGDAVKLAIGAANIDGRAYPDPDVLDLTRDRPRSNLAF
                     GHGARLCIGRTLARIELTAVFERLFRRLPELRLAVPEESLRWQEHRITGGFDEIPVTF"
     misc_feature    complement(19508..19510)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    19859..19868
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.58"
                     /tool="antismash"
     gene            19871..20341
                     /locus_tag="A7J05_RS09665"
                     /old_locus_tag="A7J05_09280"
     CDS             19871..20341
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019357668.1"
                     /locus_tag="A7J05_RS09665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7J05_09280"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_076684090.1"
                     /transl_table=11
                     /translation="MTTSQTNSPPDHLDVGALITAIENFNRFYIRLPALQTLSFTTLSV
                     LDTLTSRGPTRLTKLARTEQISQPGLTQLVTRLEQDGLVERRPDPTDGRAVLVHITEAG
                     RQVGTSRLEDRIRRLGPLVAQLSPADQRAITKALPALSRLAQLGNEEGEDRP"
     gene            complement(20408..21412)
                     /gene="gap"
                     /locus_tag="A7J05_RS09670"
                     /old_locus_tag="A7J05_09285"
     CDS             complement(20408..21412)
                     /GO_process="GO:0006094 - gluconeogenesis [Evidence IEA]"
                     /GO_process="GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /GO_process="GO:0019682 - glyceraldehyde-3-phosphate
                     metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene="gap"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011559801.1"
                     /locus_tag="A7J05_RS09670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7J05_09285"
                     /product="type I glyceraldehyde-3-phosphate dehydrogenase"
                     /protein_id="WP_076684091.1"
                     /transl_table=11
                     /translation="MTVRVGINGFGRIGRNVFRAVAARNADLEIVAVNDLGDVPTMAHL
                     LTYDSVLGRFPEEVTAEPGAIRVGDREVKVLAERDPAKLPWGDLGVDVVIESTGIFTKA
                     EKARAHIDGGAKKVIIAAPASDEDVTIVLGVNDDIYDPERHTIISNASCTTNCLGVLAK
                     VLHDTVGIEYGMMTTVHAYTQDQNLQDAPHKDLRRARSAAVNVVPTSSGAAKAIGLVLP
                     ELQGRLDAFALRVPVPTGSVTDLTVTTSRRTTVEEINEAYAKAADGAYKGLLSYTEAPI
                     VSSDIVTDPASCVYDAGLTRVMGPQVKVVGWYDNEWGYSNRLIDLALKVGSSL"
     misc_feature    complement(21401..21416)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.62"
                     /tool="antismash"
     gene            21588..22010
                     /locus_tag="A7J05_RS09675"
                     /old_locus_tag="A7J05_09290"
     CDS             21588..22010
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019357668.1"
                     /locus_tag="A7J05_RS09675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A7J05_09290"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_232626868.1"
                     /transl_table=11
                     /translation="MTQFIAVVEEFNRFYIRLPRRGNHTFSTLSVLDALAREGSPKRLV
                     DLIASEQLSRPGLTQLVQRLESDGLVERGSDPRDGRAVLVHLTEKGRGVGTSRHRERVA
                     QLTPLIARLTPEERGAITGALPALRRLARLGRDTRG"
     misc_feature    complement(21622..21640)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.25"
                     /tool="antismash"
ORIGIN
        1 cctcgccgcg ggtctcgggg gccggctccg gcgcggggcc gccggtgagc ggggccacgc
       61 ggctggggag cacggccacg gagaagtacg gcaccgactc cgggtccacc tcggcgaggc
      121 gtcccgtgcg ctcgccctcc atggtggcgc gctccacgta acgggcctcg tccaggcggc
      181 ccgcgcgctc cagggcgtcg cgcaccttgc cgaaggtgcg gccgagcttc atcacgaccg
      241 ccgagtccgt cgccgcgagg cgcgccgcca gttcctcctc ggggagggtg ccgggcagga
      301 ccgtgaggac ctcctcggct tcgacgaggg gttcgccgag ccgggccgcc gccgcgctga
      361 ccgaggtgac gccggggatg acctcggtgt cgtagcggtg ggcgaggcgc ttgtgcatgt
      421 gctggtagga gccgtagaag agcgggtcgc cctcggcgag gacggcgacc gtgcgcccgg
      481 cgtccagatg cgcggcgagg cggcccgcgg cctcctcgta gaactcgtcg agggcgccgc
      541 ggtagccgcc ggggtggtcg gtggtctccg tggtgacggg gtagaccagc ggctcctcga
      601 tgtggtcgtc ccgcaggtgc ttcgccgcga tggagcgggc gatggaacgg ccgtgccgag
      661 cggagtggta cgcgacgacg tcggcggcgg cgatgacctc gacggcccgc acggtcatca
      721 gggaggggtc gccggggccg agcccgaccc cgtacagctt ccccggcgcg atcccgaggg
      781 ccccctgagc ggtggtcccc tgcgtggtct cggtgttcac tccgcctcgc tcgcaatcgc
      841 gttgatcgcc gccgcggcca tcgcgctgcc gccgcgacgc ccccgtacga ccaggtattc
      901 caggcccgag gagtgctcgg cgagcgcgtc cttggactcg gcggcgccga cgaagccgac
      961 cggtatgccg agcacggcgg ccgggcgggg cgcgcccgcc tcgatcatct ccaggaggcg
     1021 gaagagggcg gtgggcgcgt tgccgatggc gacgacggag ccttcgaggc ggtcgcgcca
     1081 gagttccagg gcggcggcgc tgcgggtggt ggcgagctgg gcggcgaggt ccggcaccgc
     1141 cgggtcggcg agggtgcaga ccacctcgtt gtcggcgggc agccgcttgc gcgtgacgcc
     1201 gctcgcgacc atgttcgcgt cgcacaggat cggggcgccg tcgcgcagcg ccttacgggc
     1261 gtcggcgatc acgcgcgggc tgaaggcgag gtcgcggacg aggtcgacca tgccgcaggc
     1321 gtggatcatc cggaccgcga cctggctgac gtcggcgggc agccccgcga ggtccgcctc
     1381 cgcgcggatg gtggcaaagg actcgcggta gatcgccgcg ccgtccttct cgtagtcgaa
     1441 cactgtgctc tcgctcattt cgtggccgtt ggtgtggttg ccgaagtcgt acgtgccgtg
     1501 ctgaccgcct cggtgagggt gccgccccgc acgggtgtcc cgtgcccgcc ggaggtgcgc
     1561 accgtcacct cgtaccgccc gtcaccggtg gcgaggacgt cgacccagtc gccgcgcggg
     1621 tgcccgcagc gccgctcgca gccggaccag tgcacgggca gcccgccgag gccgggcacg
     1681 gcgtccgcgc ggacgtcggc gagggacttg gcgcagccgg gccgtcccgt gcaggcgccg
     1741 acgccgagcc agggcgacgc ggggtcggtg aggaacccgg cgccggccag cgcggcgagg
     1801 cggtcccgcg ccgcgcccgc gtcggcgaag ccggggagca cgaagccgcg ccacggggtg
     1861 acccgcagct cgtcggcggg cagcgggagc agggcccgcc actgggcggc ggtgacgcgg
     1921 ccgagggggg cgctgacggc gaccgcgcgg ccggtcacgc cgggggggtg cggggtggcg
     1981 cggggcgcgg tcgacggctc ggcgggcgtg gccgcgacac cggcctcttc cagcgccgcg
     2041 gccaggtcga cgcgccgccc atcgggcagc tcccgcaccc gccaggcccc gttgcccgcc
     2101 tcgcgggccg ccgcgaggaa cgccccggcc gcggcgaggg cggctcgcgg ggcgtccgcg
     2161 gcggccacgc gcagggcggg gcccccggcg cgcaccaccg ccgtcccgtc cgattctgcg
     2221 atcaaggtca catcgccgcc gagaccggcc atgtccccgc gcccgtcgtc gagggcgaac
     2281 aggaagcgcc cggacagcgc ggccgtccac tcccgcgcgc agaggagtcc gtccagctca
     2341 cgggcccaca actggacgtc ggcgcggccg agtccgtcga gtccggcgag cggggacgcc
     2401 acgatgttcc gtatgcgttc atggcgcccg gagggcagca gtccggcgtc cgtgaggagc
     2461 gcggccaggg cggagacgca gccgtcggcg aggccgcgca gctcgacgtt gccgcgcgag
     2521 gtgacgctga gggcgccgtc ggcgagccgt tccgccgcgt cggccaggac cgctgcctga
     2581 tgtcccgtca agagccctgc gggcagccgg agtcggacca gcgcgccgtc gtcggcgaga
     2641 tgcggtcgca gggctccggg acaggcgtcg ccccggtcac gtatgaggga ttcgcccttg
     2701 ttcgtggagg ttgctcgggt gggcggcatg gcggcgagca tacccacgcg cccgggcgcg
     2761 gtcgcctccc gaagtggacc gcggggacag gtggccgccc acttcggggc gggcaggact
     2821 tactatgcag tcggcgggcc gccaggtccg ccgacgccag cgacggcgtg ggcccgacag
     2881 gggcccgagg gaggaagccc ggtgcgattc cggcgcggtc ccgccactgt gagccccatc
     2941 caggtggggt gagccaggaa ctcctgccgt ccatacgacc acccggggcg cggacacccc
     3001 gaggaaggcc tgcgcccgca tgcttctgct gctgtcgacc tccgacaccg acctgctcag
     3061 cgcccgcgcg gcggggggtc ccgtcgacta ccggttcgcc aacccctccc gcctcgacct
     3121 cgccgagctg cccgccctgc tcgacggcgc cgacctggtc gtcgtacgcc tcctcggcgg
     3181 cgtccgcgcc tggcaggacg gcctcgacca gctcaccgcc agcggtctgc cggtggtcgt
     3241 actcaccggt gagcaggcgc ccgacgccca gctcatggcc tcctccaccg tgccggtcgg
     3301 catcgccgcc gaggcgcacg cctacctggc gcacggcggc cccgccaacc tggagcagct
     3361 ggcccgcttc ctctccgaca cggtgctgct caccggccac ggcttcgagc cgccggcgcc
     3421 cgcgccgtcc tggggccccc tggagcgcgc cgcgcgcgac gtcgcgggcc cgaccgtggc
     3481 ggtgctctac taccgcgccc accacatgag cggcaacacc gcgttcgtgg acgccctgtg
     3541 cggcgcgatc gaggacgcgg gcgcccgccc gctgccgctg tacgtggcct cgctgcgcgc
     3601 cccggagccg gagctgatcg aggagctgcg cgcggcggac gccatcgtga cgacggtcct
     3661 cgcggcgggc ggcaccaagc ccgccgaggc ctccgcgggc ggtgacgacg agtcgtggga
     3721 cgcgggcgcg ctgaccggcc tcgacgtgcc gatcctccag gcgctctgcc tgaccgggtc
     3781 gcgctcggcc tgggaggaga acgacgaggg cgtctcgccg ctcgacgccg ccagccagat
     3841 cgcggtgccg gagttcgacg ggcggctcat caccgtgccg ttctcgttca aggagatcga
     3901 cgaggacggg ctcccggcgt acgtcgcgga cgccgagcgc gccgcccgcg tcgccggcat
     3961 cgccgtacgc cacgcgcggc tgcggcacat cccggccgcc gacaagcgcc tggccctggt
     4021 cctgtccgcg tacccgacca agcactcgcg gatcggcaac gcggtgggcc tcgacacccc
     4081 cgcgtccgcc gtcgcgctgc tccgcaggct catcgacgag ggctacgact tcgggcccgc
     4141 cgaggagatc cccggcctgg tctccggcga cggcgacgag ctgatccggg cgctgatcga
     4201 cgcgggcggc cacgaccagg actggctcac cgacgagcag ctcgccgcca accccgtccg
     4261 catcccggcc gccgcctaca agcgctggta cgcgacgctg ccgcaggagc tgcgggagtc
     4321 cgtggaggag cactgggggc cgccgcccgg cgagatgttc ctggaccgct cccgcgtggc
     4381 ggacggcggc gaccccgagg gcgacatcgt gctcgccgcc ctgcgccgcg ggaacctgct
     4441 gatcctcatc cagccgccgc gcggcttcgg ccagaacccg atcgcgatct accacgaccc
     4501 ggatctgccg ccctcgcacc actacctggc ggcctaccgc tggatcgccg cgtccgccga
     4561 cgacggcggc ttcggcgccg acgcaatggt ccacctcggc aagcacggca acctggagtg
     4621 gctgccgggc aagaacgcgg gcctctccgc ggcctgcggc cccgacgccg cgctcggcga
     4681 cctccccctc gtctacccct tcctggtcaa cgacccgggc gagggcaccc aggccaagcg
     4741 gcgcgtgcac gccacgctca tcgaccacct ggtgccgccg atggaccgcg ccgactccta
     4801 cggcgacatc gcgcgcctgg agcagctgct cgacgagtac gcgcagatca gctccatgga
     4861 cccggcgaag ctgcccgcga tccgcgcgca gatctggacg ctcatccagg ccgcgaagct
     4921 cgaccacgac ctgggcctgg aggaccgccc ggacgacgac ggcttcgacg acttcctgct
     4981 gcacgtcgac ggctggctct gcgagatcaa ggacatgcag atccgcgacg gtctgcacgt
     5041 cctcggctcc gccccggcgg gcgccgcccg cgtcaacctc gtcctcgcga tcctgcgcgc
     5101 ccgccagatc tggggcggcg cctccgccct gccgggtctg cgcgaggcgc tgggtctcga
     5161 cgagtcggcg gcgacgcgcg cgagcgcgga cgaggccgag gagaaggccc gtgcgctcgt
     5221 ccaggcgatg gacgacgccg actgggacct ctccgccgtc cccgccgacc agagtgagca
     5281 ggtcagggcc atcctggagt tcgcggcccg cgaggtcgtg ccgcgcctgg cggccaccac
     5341 cgccgagctg gaccactccg tgcacgccct gaacggcggc ttcgtcccgg ccggcccctc
     5401 cggctccccg ctgcgcggcc tggtcaacgt cctgccgacc ggccgcaact tctactcggt
     5461 cgacccgaag gccgtcccgt cccgcctcgc gtgggagacg ggccaggccc tcgccgactc
     5521 cctcatcgag cgctaccgca cggacaacgg cgactacccc acctccgtgg gcctgtccct
     5581 gtggggcacg agtgccatgc gcacggcggg cgacgacgtc gccgaggcca tggcgctgct
     5641 cggcgtccgc ccggtctggg acgacgcctc acgccgcgtc accggcctcg aagccatccc
     5701 gtacgaggaa ctgggccggc cccgcatcga cgtgacgctg cgcatctcgg gcttcttccg
     5761 cgacgcgttc ccgcacacga tcggcctgct cgacgacgcg gtgcggctcg ccgcgtccct
     5821 ggaggagccc gccgagcaga accacgtgcg cgcccacgcc caggccgacc tggccgagca
     5881 cggggacgag cgccgggcca ccacccgcat cttcggctcg cgccccggca cctacggcgc
     5941 ggggctgctc cagctcatcg actcccgcga ctggcgcacg gacgcggacc tcgccgaggt
     6001 gtacacggtg tggggcggct acgcctacgg ccgcgggctc gaaggccgcc cggcgcgcgc
     6061 cgagatggag accgcgtaca agcgcatcgc ggtggccgcg aagaacaccg acacgcgcga
     6121 gcacgacatc gccgactcgg acgactactt ccagtaccac ggcggcatgg tcgcgaccgt
     6181 gcgcgcgctg cggggcacgg ctcccgaggc gtacatcggg gactccacgc gccccgagac
     6241 ggtccgcacg cgcacgctgg tggaggagac ctcacgggtg ttccgcgccc gcgtggtcaa
     6301 cccgaagtgg atcgaggcga tgcgccgcca cggctacaag ggcgccttcg agctcgccgc
     6361 gacggtggac tacctgttcg gctacgacgc cacgacgggg gtcgtggccg actggatgta
     6421 cgacaagctc accgagacgt acgtcctcga ccccaccaac cggcagttcc tccaggaggc
     6481 caacccctgg gcgctgcacg gcatcgccga acgcctcctg gaggcggagt cgcgcggcat
     6541 gtgggccaag ccggacccgg cggtgctcga agcgctgcgg caggcctacc tggagaccga
     6601 ggggaacctg gaggacgagg gctgagcccc gccgtcaccg acgggggccg cccagccagg
     6661 cgagggcggc cgtcgtcagg gccgtgacgc ccgtggtgat cgtcggttcg atcagcgggg
     6721 cgaagaacgg cgagtggttg gaggggatgt cccgctcgaa ggtgcccgcc cgctgcgcgg
     6781 cgatcacctt cgcggggtcg gcgccgccca gcagccagta gcagagcggg acttcgggct
     6841 ccgccgaggt ggcgaagtgt ccgacgtcct cgctgccggt cacctggccg gggtccatga
     6901 cccgctccgc gccgatgacc gcgccgaccg ccgccatcgt cctgtcgacg gcgtgcgcgt
     6961 cgttgacgac gacggggaag gtgtcgatct ccgtgatctc gggctcccgc tccgcgccgg
     7021 ccgtggccgc ctcgcccttg atgatccgct cgacggcggc gaggacgcgg gtgcggacct
     7081 cgggcgtgta ggtgcggatg ttgagctgga gttcggcctc gtcggggatg acgttgtgct
     7141 tggcgcccgc ccgcagcacg ccgacggtga cgacggcggt ctcaccgccc gccacctcgc
     7201 gggacaccac cgtctggagc cgcatcacgg tggacgcggc catcaccacc gggtcgacgg
     7261 tcgcctccgg gcgcgagccg tggccgccct tgccgaacat ccgcacccgc agggcgtcgg
     7321 tcgccgcgaa ggcgggaccc gcgtgcgcgc cgaccatgcc cgcgggcagc ggggcgacat
     7381 gctggccgag gacgacgtcg ggcgtgccga accgctcgta gaaccggtcg gcaaccatca
     7441 cccgggcgcc ctgccccgcc tcctcggcgg gctggaacac ggcgacgacc cgccccgacc
     7501 aggcgtcgcg ggagtccgcg agcagcttca gcgcgccgag cagacaggtg acgtgcatgt
     7561 cgtggccgca ggcgtgcatg acgccctcgg tgcgggaggc gtacggcagg ccggtggcct
     7621 cggtcaccgg gagcgcgtcc atgtcggcgc ggagcagcac ggccgggccc tcgccgttcg
     7681 ccagcacggc cacgacaccg gtacggccca cgccggtggt gacctcgtac ccgtacgagg
     7741 cggcgcggcg ggcggcctcc gcggcggtgc ggtgctcctc gaaggacggc tcggggtggg
     7801 cgtgcaggtg gcggtagagg tcggcgaggt cgccctggag ggcgtcgagt ccggcaaggg
     7861 cggcgggggc cgcgggggtg cggtcgcggg cggggtcgtc ggacatggcg cgctcctcgt
     7921 tgtctcgctg cggtgcgggc cactgtacgg acgaacgggc cttggatgta cgcaccactc
     7981 ggtgggccgg tcagtggcta gggtggggcc acggccccgc cgggcgcgcc ccaggaagga
     8041 agcccatgac cgagcgtagg atcccctccc ccgccgaccc ggacgcggcg gacgccgccc
     8101 tcgtctcgca gcccatcggg tactggagcg gcgcggtgca cagggccgtc acccggcgca
     8161 tccgggacgc gatggcccgc atggacgtga cgcagccgca gtggtggacg ctcaaccgcg
     8221 tcgccgccga tcccggaccc acacgcgaga cggtcgccgc ccagctcgcg gaggtcgcgg
     8281 acggcccgta cgagatcccg cgcgtcgtcg accaactcct gcaccgcggc tggctcctgg
     8341 tggaccccga gcagcggctg ttcgtgacgg acgagggccg tgaggcgatg gggcgcgtca
     8401 ccggactcgt cacgtcgctg cgggcggagg tgcacgacgg cgtcagcgat gaggactacg
     8461 tgaccacgct cagggtgctg cgcacgatgc tcggcaatct ggacggcggg aagcagcggg
     8521 cctgagccgg atcgccgtgg cggggcggcg ggacggcccc gtcccgccgc cccgctcgct
     8581 acgccccggg cgtacgggcc gtcagtcgca ggcgcagccg gcgtggctgg tagacggtgg
     8641 ccagcgggac ggggcgcacg tcgacgcccg gttcgcaggt gacccgccag gtgctgagga
     8701 tggtggcgag cgcgagggtg gcctcggtgc gggcgtagag gtcgccgatg cacttgcggg
     8761 cgccggtgcc gaaggccatg aaggactgcc gggcctgcgg tgtcacccgg tcgggcagcc
     8821 agcggtcggg gtcgaaccgc cgctcgtggg ggaaagatcc ggcgtcgagg gccacggccg
     8881 ccgggctgaa caccacggtg gaaccggcgg gcagccgcag ccccgccacg tcgaggtcgg
     8941 tggcggtcag ccgggtgaag agccaggccg gcgggtagag ccgcagggtc tcggtgatga
     9001 tgcggtcggt gagctggagc cgggccacgt cgtcgaactc cggggctctg ccgcccagga
     9061 cctcgtcgat ctccgcgtac agcgccttct cgatccgcgg gtacttggag agcaggtaga
     9121 agatccaggt gagggtggcg gcgacggtct ccgtgccggc cgccatcacg gtgatgacct
     9181 ggtcgtggat ctccttgtcg ccgagcctgc cgccgtcctc gtcgcgcgag tcgaggaggg
     9241 cggagagcag gtcgtcgtgg tcggcgccgt cgcggcggta gtcgtcgatc agcgtctggg
     9301 tggtgcggtg caggtagtcc aggttggcgc ggtagcgccg gttgcccgga ctgggcatcc
     9361 tgcgcaccgc cgcgggcagg aacatctgcc ggaacagtcc cttgagcacg gcgtcgaagg
     9421 cgcgctccac gctgtcggcc agctccttgc tgaccggcgt cgagtacagc gtgcggccca
     9481 cggtgcgcag ggccatgccg tacatctcgg gaaaggcgtc gaccaccgcg ccgtcgctcc
     9541 agcgctcggc ggtggtctcg atctcggcgt gcatcgcgga cgcgtaccgc ttgagctggg
     9601 ggcgggtgaa cgccgactgc atcagccttc tctgccggcg gtggtcggcg taggggcagg
     9661 tgaccaggcc gttgcccgcg atgtcacggg ccctgtcgta gaagatgccg cccttgtcgt
     9721 actcgttgtc gctggtcagg acctggcgga gcagggccgg atgggtcggc acatgggcct
     9781 cggtggggcc caggcgtatc ttcaccaggt cgccgtggcg ggacagcgac gacatgaact
     9841 gcagcgggcg gcgcatcatc tgccaggcgt gcccgacgag gggcgccgct ccgggcgccg
     9901 tgcccgcgac gaaggtctgc tgctcgggct gggcggtctg ctgggccatg ggttctcctc
     9961 ggtttccctc ggcgggttcg gtgcgggggt ggcgggtccg tcagcgggcg ctgccgagct
    10021 cttcgaggaa cccctggcgg ccggcggcca gcgcgaactc ggcgtcgtag cgcccggatg
    10081 agcggtgcca gtcgtacgag ccgcggatga cggggcgcac cgcgtccagg cggtagcgtt
    10141 cgacggcctc gcgctcgtcg gcggtgaggg agaaggcgtc gcagaccttg ggcaggatgc
    10201 tctccaggag caggaactcc tccaggcgta cgccgacctc gtcctgcatg tgcgcgatgc
    10261 tgcggctcct ggtccagccg tgctcgcgca tcaggatgaa caccatgttg ttcagctcgc
    10321 cgcgcgcctc ctccttctcc agggaggcga tgtcgttgag catgaggttg acgtcgacgg
    10381 cgatccgcag catcgccgac atgacggccc cgtcgaagac gcggtgcggc acctcgaagt
    10441 gcccggtggc ctcggcgagg tcgatggtgg gctgcacgcc tatcgtgtgg cggcgcatgg
    10501 cgaggtactc ccgggcggaa ccgcagggcg tctcgtcgag gcggccgtgc gcctcgtcga
    10561 cgtagccctg gaagtagtgg cgccagtgct gggcgctgcg ggtgcaccac tccttcgaca
    10621 tcccctggca ggtgcgccgc cagacgtcgg cgaagccgtg cgcgatgagg ggcgcggagg
    10681 cgggcagcgg tccgtcgagc gcggcggcga cggcgtcggt gagctgcctc gcctgctcgg
    10741 ggtcctcgcc gcgcggaccg tcgaagaggt cgtcgaagag gaagaaccag gacatcaggt
    10801 cgacgccgag gtcgaggtcg gcgccggtgg tggaggggta gaagcgggag gcgaggtcgg
    10861 cgtagccgcc cttgcggtgg cgttcggcgg cggcctcgct gctgatgagg ccgaaggagc
    10921 ggggccactc gatgtgtgcg gcctcggccc gcgcgtggtc ggggctgcgg cggccgggca
    10981 gggggatgga gaagtcgacg tcctggggca tggggagact ccctgggcag tggaacaggg
    11041 cgcgagcggg cgcccgaacg ggggtggggg cacgcaccgg ggcgacgctg cccgcggtgc
    11101 gcggcgtacg cggacgtggg gtgggcggag gcggtgcacg cggggacacg cggctacggg
    11161 ggcaggtccg ggctcagccc tcgcggtcga cgacgaaacg gccgagcgcg aggagttcgt
    11221 cccgtgctcc ggcgtccagg tcgacgccgc gcagcgcggc ctcggccagg gccatgcgcc
    11281 gggcggcctc ggccagcgcc cagtcacggc cgccggcgcc ctcgaccagg gcggccgccc
    11341 ggcgcagttc ctcctcgccg ggttcgccgc gggtggcgag ccaggcggcg agttcggcgc
    11401 tgagcgggcc gtcctggtgc agggcgtggc tcaccggcag ggtcttcttg cgggagcgca
    11461 ggtcggagtg ggccgacttg ccggtgacgg cggggtcccc ccagatcccg agtacgtcgt
    11521 cgacgagctg gaaggcgatg ccgacgtggt cgccgtagag cgcgagggcg tccaccgtcg
    11581 cctcgggcgc cccggcgagg acggcgccga tcgccgcgct cgccgacagc agggcgccgg
    11641 tcttgcccgc ggccatgtcg aggcactcct cgaccgtgac gtggccgcgc tgttcgaagg
    11701 acaggtcctg gacctggccg cgaatcaggt gccgggtggt gcgcgcgagc agccgggcgg
    11761 cgggcgccgc cgtcggcagc ccggtgtcga gcagcacctc ctgggcgagg gcgagcatcg
    11821 cgtcgccggt caggatggcg ctggaggggc cccacagctt ccacaccgtg cgccggtggc
    11881 ggcgctcctc gtcgccgtcc atcaggtcgt cgtgcaccag ggagaagttg tgcaccagct
    11941 ccacggcgac ggcgccgggc agggcgacct ccggcggcgc gccgaccgcc tccgcggaga
    12001 gcagggcgag cgccgggcgt acggccttgc ccgcgtcggc gctggtgggc gcgccgccgg
    12061 cggtgatcca cccgaagtgg taggccgcct ggtggcgtga gcggtggtcg agccggtcga
    12121 cggcggcgcg cagcgccggg gtgatcgtga cgcggctgtg gctgaggcag gcgggagcgg
    12181 tgctcatgcg gcggcctccg ctcgccaggg ggcggtcggg tcgtcgaaga tgctgacgac
    12241 ctggcgcatg acgcgccgtt cggccgggtc gaaggcccgc ttggcgtgga cggtgccgag
    12301 ctggtcccac atgacgatgt ccccgggccg ccaggtgtgg gcgtaggtgt gccggggggt
    12361 gcccgcgtgc gcgaggagct tgtcgagcag ttcgcggccg gcgtcggggg cgaggtccac
    12421 gatccgctcg gtgttcaggg tgctgacgta gaccgagcgg cggccggtgc gcgggttgcg
    12481 ggcgaccagc gggtggacgg tggaggtgcc gtcctcggcc ctgatccgac gggggtcctc
    12541 gccgagggac acctcgccct ggagttcctc ctcgatggtc tcctcgtagc cggtgcgcag
    12601 ggcgtggcgg acccggtagg agtgcagacg ccggcgctcc tcggcgggca gggactcgta
    12661 cagggcgtac atgtcggtga agagggtctc gccgccgccg gagggcggca cttcgacggc
    12721 ttcgaggaag ccgacctggg agacgcgggg gcggaaggag tagtcggtgt gccagcccat
    12781 ccacccggcg tcgccgacgc cgatcttgcg gccgtcctcc accaggttgg agacgatcag
    12841 gatctcattg tggtcggggt gggcgccgct ggtcaggccg gtcttcggga tatgcccgaa
    12901 gcggcggccg aaggccagga actcctcgta ggtcggggtc tcgtggccgc ggaagaccag
    12961 gacgaggtgc gcgtcgagcg ccgcccagat ctcgttcgcc tgtgcctcgt ccatgtcgcc
    13021 cgagacatgg gcgccgtcca cgacggcgcc gagagcggcg ccgggtatcg gcgtgacgtc
    13081 catggtcctt gccgcctttc gcagaggggt gggatggtca gcgcaggtcg agtccggcga
    13141 ggtcgcccgc ctcgcgccag cgtcggagga tgttcacgaa ctccacggag ccgccgccgt
    13201 agctggagtt gagcagcggc agtccgcccg ggtcgccctc gttgttgtag aggccgggcg
    13261 tgcagttctc caggaagtcc aggtcgctgc tggcgaggcg gaggatctcc tccacccact
    13321 ccttctcgcc ggcctcggag gcctcgacga cccggtggcc gcgctcctcg acgcacttga
    13381 cgatgtgcgc gaggtgccgg gtctgctcgc ccagcatgta ggcgatgttg acgtgcctcc
    13441 ccgcctggac cttggacagg atgaagcagt tggggaagcc gttcacctgg agcccgtgca
    13501 gggtgcgcgc cccgtccgcc cacttctccg acagccgcgt gccgccgcgg ccgacgatgt
    13561 cgtagccggc gcgctcggtg tacgggacgg cgaactcgtg ctcgtagccg gtggcgaaga
    13621 tcaggcagtc gaccgggtac tcgcggccgt tggcgaccac cccggcgggg gtgagccgtt
    13681 ccacgccctg cccctgggtg tcgacgaggg tcacgttggg ccggttgaag gtctggaggt
    13741 agccgtcgtg gaagcagggc cgcttgcagt acacgcggta gtacggcttg agggcggcgg
    13801 cggtcgcggg gtcggtgacg acgctgtcga tgcgggcccg cagctcctcc atcttgagga
    13861 agtccgcccg ctcggccgcg agcgcccgct ctttcgggtc tcccccggtg tcgccggtgg
    13921 gcaggatcgc ggcggcgagc ttggccgtgg tctgggtcca gcggtcctgg accaggtcct
    13981 cgtcctgcgg gatgccggag gtcagtgcgt ggaagttctc catgcggcgc tgctgccagc
    14041 ccggttccag gctctccgcc cagccgggcg gggtgggccg gttgccgcgg acgtcgaccg
    14101 tggcgggggt gcgctggaag aggacgagtt ccttggccca ctcggcgagg tgcggggcga
    14161 gctggatggt cgtcgagccg gtgccgatga cgccgacccg cttgtccctc agcccggtca
    14221 ggccgccggt gctgtcgccg ccggtgtagt cgaagtccca gcggctggcg tggaaggagt
    14281 gcccggcgaa cgcgtcgagg cccggcagtc cggggagttt ggggcggtgc atcaggccga
    14341 tcgacatggc cacgtagcgg gcgcggatca catcgccccg gtcggtgctc accagccacc
    14401 tcgcggcggc ctcgtcccag cgcagctccg tgacggtggt ctggaagagg gcgtcgcggt
    14461 agaggtcgta ctcgcgggcg atccgctgga ggtgggcgaa gatctcgggt cctgtggagt
    14521 acttctcggt gggtatcgtg ccggtctctt cgagcagcgg catgtagatg tagctctcga
    14581 cgtcgcaccg gacgccgggg aagcggttcc agtaccaggt gccgcccacg tcgccggcct
    14641 cgtcgatcag ccggatgcgg tcgaggcctg tctccttgcg caggttggcg ccggtcagca
    14701 ggccgccgat gccggcgccg acgacggcga cgtccacctc gtcggtgagc ggttcgcgct
    14761 cccgccgctc ggtgtagggg tcgcgcgcgt agtggctgaa gtcgccgcgc gcgaactggt
    14821 aggtgcggcc ggcgccgcgc ttgtcgcgtt cctgccggta cttctcccgt atcgccgcca
    14881 ggtcgatggg tggtgcttct tcggtcggcg cctcttcggt cggtgcatct tcggtcagtg
    14941 cttcgtcgct ccggtcgtcg ccttcggtgc gggccacagc tcctcctcgg gggaaggggg
    15001 cgaaagggaa acatgacgcc atacgtcatc gaactgatcg cgcagccgct gcggcgcgtc
    15061 ggagttgctg aagaggtaga agcggtcgga gccgagggcg tccaccacga cgccggcgac
    15121 ggcctcggcg ctcaccgagg tgtcgccgcc cgcgccgcgc ggcgcggtca ggccctggac
    15181 catgggggtg tcgacccggc cggggcacag caccgacacc cggatgccgg tgtccgccag
    15241 gtcggcgcgg aggctgcggg cgaccgcgag gtcggcgtgt ttggacgcgg cgtaggcggc
    15301 actgcccgca ccgacgacga aggcggacat cgaggcggtg tggaccaggt gggcgggccg
    15361 gccgcgggcg aggagccgcg gcacgaaggc gcgcgccacc agcacgtgcg cccagtggtt
    15421 cacctcgaag acctcccgca tccgctccag cggcgcctcc cacaggggct gtcccacggg
    15481 gccgaggacg cccgcgttgt tgcacaccac gtcgatgtcg ccgagcacgt cgaacgcggt
    15541 gtccgcgagc cgttcgacgg cgtccgggtc ggtcaggtcg gcggtcaccg cggtgacctg
    15601 gccgccctgg gccgtgagtt cggcggcacg gcggcgcagc gcgccgccct cgacgtccgc
    15661 catgatcacg ctggcgccgg cgcgtgcgag gcgcgcgctg agggcgaggc cgatgccgct
    15721 ggccgcgccg gtcacgacgg ccgtctgggt ctgcgagtgc acgtggctgt ctccgcttct
    15781 gcgcacgggc acgccgacga agcggcgcgc cgtcgcccac gagaaggtct ggatcggatc
    15841 gcgccgttcg cggggcgcgg gcgttaccgg gggtcgggga gcttcaggct gatcacgaga
    15901 acggtcaccg agcagcatgc gaggagcgcg aggacgccca cggccgccga caccgtcgac
    15961 tgccagtcgg ccagggagag atagacggtc ccgccgacgg tcgcgccgag cgcggtcgcc
    16021 atctgctggc tggtcaccag cacaccgctg cccatgccgg cctgcgcggg cggtacgtcg
    16081 gcgaggatca tccggaacag cgtgggaccg gtcagcgccg cgcccacgcc gtagaggccg
    16141 atccccacga ggacgagcgt cagggagggg tgcggccagc ccagccggat caccagcgcg
    16201 agcagcagca ggcccgcgcc ttggacgaag gcgcccaggg tgacgatccg ggcgccgagg
    16261 gccgccgcga tcctcggggt gaacagcgtc accgcgaaga acgccacggc gaacggcgcg
    16321 aggcccccgc cggattcgag cccgtcgaag ccgaagtgcc cctgcgcgac gagtgcgtag
    16381 acgaacagga aggcgccgaa gcccgccgag aacggcacca tcgccgccag gcccctgcgc
    16441 atcccctggt gggagagcac cgacggggac agcagcggtg agccgccccg cgcctcgagt
    16501 ccgcgctcga cccgcgccag cgccaccgcg cccgccgccg cgaccagcag cagcgaccac
    16561 agccacggcg gccaccccag ctcggggccc gccacgacca gggcgaggac gcagaccatg
    16621 gtgaggccga acagggcggt gccccggggg tcgaaggacg gcttcgcgtc ggccttcgtc
    16681 gcggggacgc gccggacggc gagcagtgcg gccaccccga tgggcacgtt gatcgcgaag
    16741 accgcccgcc agccgatccc ggcgatgtcc agcgagacga ggagcccgcc gaggatctgt
    16801 ccgatgacca taccgagggc ggcggtcgcg ccgtacatgc cgatggcgcg ggcgcgcgcc
    16861 tgaccctcgg tggccgcctg gatcgtggcg agcacctgcg gcacgagcat ggcggcggcg
    16921 gcgccttgga gcagccgggc cgcgacgagg aactcgatgg tcggcgcgag tccgcagagc
    16981 gccgaggtga gggtgaacgc cgcgagcccg taggcgtaca ggcgctgccg gccgaaggcg
    17041 tcaccgagac gtccgccgag cacgaggccg agggcgtagg tgaggccgta gccggacacc
    17101 accagttcga gtgcggcggg gccgccgtgg aggtcgtcac tgatcgggtt cagcgccacg
    17161 ttgacgatgg aggcgtccac gatggacagg gcgtatccgg tgagcaccac cacgagggcg
    17221 atgccgctga gccccgtggc ggccggccgg gggccggccg ggggctcggg tgccgcggtg
    17281 ggtccctgcg gagaggggag accctcgcgt tgtgtcatgc gctgcctacc cgggcgtgtg
    17341 tgggggacgg tggggactgg ttcgggggtg ggaaggtcat tcgatggtgg tgggcgtacc
    17401 ggtgatcttc gacaggattc ccttggaggc gtccttcgcg gactccggcc agggcgtcag
    17461 ggagttgaac ccgcggtgcg aggtggcggg ctggacgcgg gtgtccatcg acatccgcat
    17521 ggcggccggg tccgcggaga cgttcgggat ggacttgtgg cacatgtagg cgtggaagag
    17581 gagcacgtcc cccggttcca tgggcgagaa cagcaggcgc tcgtccgcgc cgaactcctc
    17641 ggcggggata ccgcgtacgg ggtggccgaa gcggcggaag ttctcggtga cgacgtgctc
    17701 gcgcgggccc ttcttgtggc tgccgtcggc gagggcgacg ccgcccgtcc cgggggtcgt
    17761 cgggagcagc ggtatccagg cggtgcggaa gtccttgttc ggccctatgt agaagccgtc
    17821 ctggtgcagg ggcgtcagga agtgcggttc ctccgagccc gcggcgcccg cggcggaggg
    17881 gtaatagcgg atcgtcgtcg acttgaagac gaagacgggc tcgccgaagg ccttctccca
    17941 gaccttgagg gtggaggggt ggttccacag gtcgtcgtac ttgacgtagt cgtgcatcgc
    18001 cacctcgtcg accgcctcga aggattcgat ggtgagggtc tccagcgtgg tgccgggagc
    18061 ggcgtggccg agggcgatca ggccttcgag catctgctcg gcggcggtcc gcacgaggtc
    18121 gcggtcgagg acgccgcgca gatagaggta gccgtgctcg tcgtagaacc ggtcgagggc
    18181 ctcacggtcg tcgatgaggg gcgtgcagtc ggcgtagtcg ctgaaagtgt ccgtcatgat
    18241 ccttgtcctc gtggtgtccg cgcgggggaa ggaggagttc gatgcggagg ttcctgctgg
    18301 gggcgggccg ccggcggccg gcggacgccg ctcagaacgt cacggggatc tcgtcgaagc
    18361 cgccggtgat gcggtgctcc tgccagcgca gggactcctc ggggacggcg agccgcagtt
    18421 cgggcagcct gcggaacagc cgctcgaaga cggccgtcag ctcgatgcgg gccagggtgc
    18481 ggccgatgca gaggcgggcg ccgtgcccga aggccaggtt cgacctgggc ctgtcccggg
    18541 tcaggtcgag cacgtccggg tcggggtagg cccggccgtc gatgttggcc gcgccgatgg
    18601 ccagtttcac cgcgtccccg gcccggatca cggtgtcgcc cacggtgatg tcgctgtggg
    18661 cgtagcgggg tatcagcgcg ttggagccct tgccgccgac gccgaggcgc aggatctcct
    18721 cgaccgcggc gggcgcgagt cccgggtcct cgacgagttg cgcgcgctgg gccgggttgc
    18781 ggaacagcag cagggtgccc aggtcgatgc ggacgatggt ggtctcgtag ccgaacagca
    18841 ggacggcggc gcccagttgg acgatctcct cgtcggacag ggcgccgtcc ttggcggaga
    18901 tcagctcgga gaggatgtcg tcgcccggct cggtccgctt gcgggccacc agttccctca
    18961 gatagtcgac gaccttcttg aaggtgttcg ccgagtgctg gtcgtcgctg tggtcgaagg
    19021 tgcctctcgc gtactgcccg aaccgctccc ggtcgtccag cggcacgccg agcaggtcgc
    19081 agaccaccat ggtcggcagc gggaacgaca gggcgcggtg caggtcgacg ggcggggcgc
    19141 tcacggccaa ctggtcgagc agttcgtcca catggcgctc gatgcgggtc tgcatccggc
    19201 gcatgcggcg cgtggagaac aaggggacga gcagggcgcg catctgggcg tgccgggcgg
    19261 gctcggtcgc gcagtcgtcc ccggccatca gggcgaccat gaagcccctg gcggcgctgt
    19321 tggccgactg ctcggggtcg gggttgctga ggcggaggcg ggggtcggcg agcagtgtcc
    19381 tgacctcgtc gtaccgggtg accagccagg cgtcctcacc ggcggtccgc accctggcga
    19441 tcggcccttc ccgctgcagt gcccgcatct gcggcgcgat gcccatgatg gacgggttgt
    19501 cgaagggtaa cctcggaagt tccgtcacgt gtccatgctc atttccccga ggcctttcgg
    19561 cattcctctg aaagcgcccc ggatcgacag cggcgggaaa ttctgcgtca gtgtctgctc
    19621 ttcaccgtct tcaccgcgac gggagcgcgc ggcttgggcg gggccggttc atggggaggc
    19681 cacgatgccg aggtccgtgc tccgtgcggt gccgatacgc gtgggcatgg atgcgttcct
    19741 cgctctgcgc tactgacgtg ggccgacgcg ccattgcgcc atggaggtcc ggaacggccc
    19801 gcataccgcc gcgaggcgcc gacctcgaat gcatcaacga gactatataa gtgtgcgcta
    19861 tttttctagg gtgaccactt cgcagaccaa cagcccgccg gaccacttgg acgtgggcgc
    19921 cctgatcacg gcgatcgaga acttcaaccg cttctacatc cgcctgccgg cgctgcagac
    19981 gctgtcgttc acgacgcttt cggtgctcga caccctgacc tcccgcggcc cgacgcggct
    20041 caccaaactg gccaggaccg agcagatcag ccagccgggc ctcacccaac tggtcacgcg
    20101 tctcgaacag gacgggctcg tggaacgccg tcccgacccg acggacggac gcgccgtcct
    20161 cgtccacatc acggaggcgg gccgccaggt cggcacgtcg cgcctggagg accgcatccg
    20221 gcgcctgggc ccgctcgtcg cccagttgtc gcccgcggac cagcgggcga tcacgaaggc
    20281 gctgccggcg ctctcccgcc tcgctcaact cggcaacgag gagggcgagg accggccgtg
    20341 acggatcggc ccgacgcccc gcgagggcgc gagccggacc cgtcgacgac cggtcccacg
    20401 acgggcctca gagcgaggag ccgaccttca gggcgaggtc gatgaggcgg ttggagtagc
    20461 cccactcgtt gtcgtaccag ccgacgacct tgacctgcgg gcccatcacg cgggtgagcc
    20521 cggcgtcgta gacgcaggag gccgggtccg tgacgatgtc ggagctgacg atgggcgcct
    20581 cggtgtagga gagcagcccc ttgtacgcgc cgtcggcggc cttcgcgtac gcctcgttga
    20641 tctcctcgac cgtggtgcgg cggctcgtgg tgaccgtcag gtcggtgacc gagccggtcg
    20701 gcacggggac ccgcagcgcg aatgcgtcga ggcggccctg gagttcgggc aggacgaggc
    20761 cgatggcctt ggcggctcca ctggacgtcg gcaccacgtt gacggcggcc gagcgcgcgc
    20821 ggcgcaggtc cttgtgcggg gcgtcctgga ggttctggtc ctgggtgtag gcgtggaccg
    20881 tggtcatcat cccgtactcg atgccgaccg tgtcgtgcag caccttggcc aggacgccca
    20941 ggcagttggt ggtgcaggag gcgttggaga tgatcgtgtg gcgctcgggg tcgtagatgt
    21001 cgtcgttgac acccaggacg atggtgacgt cctcgtcgct cgcgggggcg gcgatgatca
    21061 ccttcttggc gccgccgtcg atgtgcgcgc gggccttctc ggccttggtg aagatgcccg
    21121 tggactcgat gaccacgtcc acccccaggt cgccccaggg gagtttcgcg gggtcgcgct
    21181 cggcgaggac cttgacctcg cggtcgccga cccggatggc gccgggctcg gcggtgacct
    21241 cttcggggaa acggccgaga accgaatcgt aggtcaggag gtgggccatg gtcggaacgt
    21301 cgcccaggtc gttgaccgcg acgatctcca ggtccgcgtt cctggcggca accgcccgga
    21361 agacgttcct cccgatgcgg ccgaagccgt tgatacctac acgaacagtc atgcgttcct
    21421 ctcacagcgt ttgaggctcg acagtcgggg agagggtggc cgcgcaggac gcgccagccg
    21481 tgccggccac ccgaaacacc ataagcaact tgtgtaagtt atcaatacat cgccacttcg
    21541 caagctatag gctccccggc gtgcgcgcct ccggaaacca tctgaatgtg actcagttca
    21601 tcgccgtcgt cgaggagttc aaccgtttct atatccggct gccacgtcgg ggtaaccaca
    21661 ccttcagcac gctgtcggtg ctcgacgccc tcgcccgcga gggcagcccg aaacggctgg
    21721 tcgacctgat cgcgagcgaa cagctcagcc gcccggggct cacccagctc gtccagcgcc
    21781 tggagagcga cggcctcgtg gaacgcggga gcgacccgcg cgacggccgc gccgtcctcg
    21841 tccacctcac cgagaagggc cgcggcgtcg gcacgtcacg gcaccgggaa cgggtcgcgc
    21901 agctcacccc gctcatcgca cggctcaccc ccgaggagcg cggcgcgatc accggggcac
    21961 tgcccgccct gcggcgcctc gcacggctgg gaagggacac acggggctga ccggggcccg
    22021 gcgtcagccg acccgtcgca gcgccttctc cctgcgttcg gccacggccg atccggactc
    22081 ccgccgggcc atgcgccgca gcacgacggg ggcgaggacg agaccggcga tcgcccaccc
    22141 cgtcaggact ccgacggtct ccagatgccg ccaggactcg ccgatct
//
