Select genomic region:
Overview
1.1
1.2
1.3
1.4
1.5
1.6
1.7
1.8
3.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP016896.1 (Acinetobacter soli)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | terpene-precursor | 39,203 | 60,111 |
Region 1.2 | redox-cofactor,RiPP-like | 459,294 | 481,487 | Low | bacillomycin D | NRPS:Type I+PKS
Region 1.3 | betalactone | 1,054,879 | 1,083,951 |  |
Region 1.4 | RiPP-like | 1,303,928 | 1,314,791 |
Region 1.5 | t3nrps-iterative,NRP-metallophore,NRPS | 1,825,933 | 1,881,842 | High | fimsbactin A | NRPS:Type I
Region 1.6 | arylpolyene | 1,922,918 | 1,964,144 | Low | berninamycin K/berninamycin J/berninamycin A/berninamycin B | ribosomal:RiPP
Region 1.7 | NAPAA | 2,492,125 | 2,526,117 |
Region 1.8 | arylpolyene | 3,331,984 | 3,373,189 | Low | APE Vf | other:other

NZ_CP016898.1 (Acinetobacter soli)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 3.1 | lassopeptide | 9,886 | 32,188 |

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | terpene-precursor | 39,203 | 60,111 |
Region 1.2 | redox-cofactor,RiPP-like | 459,294 | 481,487 | Low | bacillomycin D | NRPS:Type I+PKS
Region 1.3 | betalactone | 1,054,879 | 1,083,951 |  |
Region 1.4 | RiPP-like | 1,303,928 | 1,314,791 |
Region 1.5 | t3nrps-iterative,NRP-metallophore,NRPS | 1,825,933 | 1,881,842 | High | fimsbactin A | NRPS:Type I
Region 1.6 | arylpolyene | 1,922,918 | 1,964,144 | Low | berninamycin K/berninamycin J/berninamycin A/berninamycin B | ribosomal:RiPP
Region 1.7 | NAPAA | 2,492,125 | 2,526,117 |
Region 1.8 | arylpolyene | 3,331,984 | 3,373,189 | Low | APE Vf | other:other
Region 3.1 | lassopeptide | 9,886 | 32,188 |

No secondary metabolite regions were found in these records:
  NZ_CP016897.1 (Acinetobacter soli)
  NZ_CP016899.1 (Acinetobacter soli)
  NZ_CP016900.1 (Acinetobacter soli)
  NZ_CP016901.1 (Acinetobacter soli)
  NZ_CP016902.1 (Acinetobacter soli)
  NZ_CP016903.1 (Acinetobacter soli)

Compact view
NZ_CP016896.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 39,203 - 60,111 nt. (total: 20,909 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: acetyltransferase
BEN76_RS00230: GCN5-related N-acetyltransferase

smcogs
  SMCOG1111: GCN5-related N-acetyltransferase

Ligases: synthetase
BEN76_RS00245: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Translocases: permease
BEN76_RS00240: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000016.4 |  | 0.44 | other (other) | amphotericin B | Streptomyces nodosus
BGC0002219.2 |  | 0.39 | terpene | (-)-(R)-nephthenol | Stereum hirsutum FP-91666 SS1
BGC0000643.3 |  | 0.38 | terpene | carotenoid | Brevundimonas vesicularis
BGC0002571.2 |  | 0.38 | NRPS | pyoverdine DC3000 | Pseudomonas syringae pv. tomato str. DC3000
BGC0000634.3 |  | 0.37 | terpene | carotenoid | Brevundimonas sp. SD212
BGC0000557.5 |  | 0.37 | ribosomal | streptococcin A-FF22 | Streptococcus pyogenes
BGC0000043.5 |  | 0.37 | PKS | curacin A | Moorea producens 19L
BGC0000527.5 |  | 0.37 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000547.5 |  | 0.37 | ribosomal | salivaricin 9 | Streptococcus salivarius
BGC0000635.3 |  | 0.37 | terpene | carotenoid | Paracoccus sp. N81106

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000016.4 |  | 0.44 | other (other) | amphotericin B | Streptomyces nodosus
BGC0002219.2 |  | 0.39 | terpene | (-)-(R)-nephthenol | Stereum hirsutum FP-91666 SS1
BGC0000643.3 |  | 0.38 | terpene | carotenoid | Brevundimonas vesicularis
BGC0002571.2 |  | 0.38 | NRPS | pyoverdine DC3000 | Pseudomonas syringae pv. tomato str. DC3000
BGC0000634.3 |  | 0.37 | terpene | carotenoid | Brevundimonas sp. SD212
BGC0000557.5 |  | 0.37 | ribosomal | streptococcin A-FF22 | Streptococcus pyogenes
BGC0000043.5 |  | 0.37 | PKS | curacin A | Moorea producens 19L
BGC0000527.5 |  | 0.37 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000547.5 |  | 0.37 | ribosomal | salivaricin 9 | Streptococcus salivarius
BGC0000635.3 |  | 0.37 | terpene | carotenoid | Paracoccus sp. N81106

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
BEN76_RS00245: PT_FPPS_like
Domain 1 (36 - 301): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  IPP, DMAPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.82 out of 21.84
Confidence: medium
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.38 out of 26.85
Confidence: medium
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.82 out of 18.46
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.91 out of 29.38
Confidence: medium
Additional weak hits (4):
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 27.93 out of 36.54
Confidence: weak
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.81 out of 27.55
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.74 out of 29.65
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.69 out of 36.53
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
FuR variant 1 | Ferric Uptake Regulator
MexT | Global virulence regulator
RpoN | Regulator of nitrogen assimilation and virulence
RutR | Regulator of the pyrimidine and purine metabolism

NZ_CP016896.1 - Region 2 - RiPP-like,redox-cofactor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 459,294 - 481,487 nt. (total: 22,194 nt) Show pHMM detection rules used
redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
BEN76_RS02225: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acetyltransferase
BEN76_RS02195: acetyl-CoA acetyltransferase

smcogs
  SMCOG1124: acetyl-CoA acetyltransferase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | redox-cofactor | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001098.5 |  |  | 0.25 | NRPS, PKS | iturin | Bacillus subtilis
BGC0001090.5 |  |  | 0.25 | NRPS, PKS | bacillomycin D | Bacillus velezensis FZB42
BGC0000231.5 |  |  | 0.25 | PKS | griseusin A, griseusin B | Streptomyces griseus
BGC0000607.5 |  |  | 0.23 | ribosomal | micrococcin P1 | Macrococcus caseolyticus
BGC0000218.5 |  |  | 0.22 | PKS | doxorubicin | Streptomyces peucetius
BGC0002496.3 |  |  | 0.22 | NRPS | serratiochelin A, serratiochelin C, serratiochelin B | Serratia plymuthica
BGC0000217.5 |  |  | 0.21 | PKS | daunorubicin | Streptomyces sp.
BGC0001510.5 |  |  | 0.20 | other (other) | anisomycin | Streptomyces hygrospinosus
BGC0000234.5 |  |  | 0.20 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0002284.3 |  |  | 0.20 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000866.5 |  | 0.43 | other (other) | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0001098.5 |  | 0.43 | NRPS, PKS | iturin | Bacillus subtilis
BGC0001090.5 |  | 0.42 | NRPS, PKS | bacillomycin D | Bacillus velezensis FZB42
BGC0000231.5 |  | 0.42 | PKS | griseusin A, griseusin B | Streptomyces griseus
BGC0000867.3 |  | 0.41 | other (other) | polyhydroxyalkanoic acids | Ectothiorhodospira shaposhnikovii
BGC0002496.3 |  | 0.39 | NRPS | serratiochelin A, serratiochelin C, serratiochelin B | Serratia plymuthica
BGC0000218.5 |  | 0.39 | PKS | doxorubicin | Streptomyces peucetius
BGC0000043.5 |  | 0.38 | PKS | curacin A | Moorea producens 19L
BGC0000217.5 |  | 0.38 | PKS | daunorubicin | Streptomyces sp.
BGC0000607.5 |  | 0.38 | ribosomal | micrococcin P1 | Macrococcus caseolyticus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.53 out of 26.06
Confidence: strong
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 20.47 out of 20.47
Confidence: strong
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.55 out of 18.46
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.06 out of 28.19
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.54 out of 32.93
Confidence: medium
Additional weak hits (3):
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.53 out of 33.73
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.79 out of 26.06
Confidence: weak
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.31 out of 25.88
Confidence: weak
RREFinder
TFBS Finder
RRE predictions
RREfinder results sidepanel.

redox-cofactor protocluster (459293...481487)
BEN76_RS02240
  RRE type: PqqD_RRE
  Location: 5 - 90
  Score: 108.1
RiPP-like protocluster (460910...472326)
BEN76_RS02240
  RRE type: PqqD_RRE
  Location: 5 - 90
  Score: 108.1

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
LexA variant 3 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
RpoN | Regulator of nitrogen assimilation and virulence
ToxT | Regulator of MSHA biosynthesis
VqsM | Regulator of quorum-sensing signalling systems
ZuR variant 1 | Zinc-responsive repressor

NZ_CP016896.1 - Region 3 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,054,879 - 1,083,951 nt. (total: 29,073 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
BEN76_RS05250: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

Transferases: acyltransferase carboxylase methyltransferase transferase
BEN76_RS05235: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

BEN76_RS05245: acetyl-CoA carboxylase, carboxyl transferase,

smcogs
  SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

BEN76_RS05265: methyltransferase

smcogs
  SMCOG1089: methyltransferase

BEN76_RS05280: acyltransferase 3

smcogs
  SMCOG1088: acyltransferase 3

Lyases: hydratase
BEN76_RS05240: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase
BEN76_RS05230: 2-isopropylmalate synthase

smcogs
  SMCOG1271: 2-isopropylmalate synthase

BEN76_RS05260: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002284.3 |  | 0.56 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0001160.5 |  | 0.52 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0000706.3 |  | 0.44 | saccharide | kanamycin | Streptomyces kanamyceticus
BGC0002493.3 |  | 0.43 | NRPS | parabactin | Paracoccus denitrificans PD1222
BGC0000234.5 |  | 0.43 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000207.5 |  | 0.42 | PKS | chartreusin | Streptomyces chartreusis
BGC0000922.5 |  | 0.41 | PKS | 2-heptyl-3-hydroxy-4-quinolone, 2,4-Quinolinediol, 2-heptylquinolin-4(1H)-one | Pseudomonas aeruginosa PAO1
BGC0000662.5 |  | 0.41 | terpene | grixazone A | Streptomyces griseus subsp. griseus NBRC 13350
BGC0002711.2 |  | 0.41 | PKS | nostovalerolactone, 9-dehydronostovalerolactone | Nostoc punctiforme PCC 73102
BGC0000253.4 |  | 0.41 | PKS | oviedomycin | Streptomyces antibioticus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002284.3 |  | 0.56 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0001160.5 |  | 0.52 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0000706.3 |  | 0.44 | saccharide | kanamycin | Streptomyces kanamyceticus
BGC0002493.3 |  | 0.43 | NRPS | parabactin | Paracoccus denitrificans PD1222
BGC0000234.5 |  | 0.43 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000207.5 |  | 0.42 | PKS | chartreusin | Streptomyces chartreusis
BGC0000922.5 |  | 0.41 | PKS | 2-heptyl-3-hydroxy-4-quinolone, 2,4-Quinolinediol, 2-heptylquinolin-4(1H)-one | Pseudomonas aeruginosa PAO1
BGC0000662.5 |  | 0.41 | terpene | grixazone A | Streptomyces griseus subsp. griseus NBRC 13350
BGC0002711.2 |  | 0.41 | PKS | nostovalerolactone, 9-dehydronostovalerolactone | Nostoc punctiforme PCC 73102
BGC0000253.4 |  | 0.41 | PKS | oviedomycin | Streptomyces antibioticus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.00 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.52 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.26 out of 27.78
Confidence: medium
Additional weak hits (3):
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.12 out of 28.14
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.98 out of 29.25
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.18 out of 26.85
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes

NZ_CP016896.1 - Region 4 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,303,928 - 1,314,791 nt. (total: 10,864 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002133.3 |  | 0.38 | ribosomal | group 1 methanobactin | Methylosinus sp. LW3
BGC0002489.2 |  | 0.32 | other (other) | pseudopaline | Pseudomonas aeruginosa PAO1
BGC0000947.5 |  | 0.23 | other (other) | vibrioferrin | Vibrio alginolyticus
BGC0002465.2 |  | 0.22 | NRPS | amphibactin E, amphibactin H, amphibactin I | Alcanivorax borkumensis SK2
BGC0000386.5 |  | 0.22 | NRPS | malleobactin A, malleobactin B, malleobactin C, malleobactin D | Burkholderia thailandensis E264
BGC0002691.2 |  | 0.21 | NRPS | amphibactin B, amphibactin C, amphibactin D, amphibactin E, amphibactin H, amphibactin S, amphibactin T, amphibactin V | Vibrio neptunius
BGC0000424.5 |  | 0.21 | NRPS | serobactin C, serobactin B, serobactin A | Herbaspirillum seropedicae SmR1
BGC0001189.5 |  | 0.21 | NRPS | taiwachelin | Cupriavidus taiwanensis LMG 19424
BGC0002571.2 |  | 0.21 | NRPS | pyoverdine DC3000 | Pseudomonas syringae pv. tomato str. DC3000
BGC0001721.3 |  | 0.21 | NRPS | ornibactin | Burkholderia cepacia

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002133.3 |  | 0.38 | ribosomal | group 1 methanobactin | Methylosinus sp. LW3
BGC0002489.2 |  | 0.32 | other (other) | pseudopaline | Pseudomonas aeruginosa PAO1
BGC0000947.5 |  | 0.23 | other (other) | vibrioferrin | Vibrio alginolyticus
BGC0002465.2 |  | 0.22 | NRPS | amphibactin E, amphibactin H, amphibactin I | Alcanivorax borkumensis SK2
BGC0000386.5 |  | 0.22 | NRPS | malleobactin A, malleobactin B, malleobactin C, malleobactin D | Burkholderia thailandensis E264
BGC0002691.2 |  | 0.21 | NRPS | amphibactin B, amphibactin C, amphibactin D, amphibactin E, amphibactin H, amphibactin S, amphibactin T, amphibactin V | Vibrio neptunius
BGC0000424.5 |  | 0.21 | NRPS | serobactin C, serobactin B, serobactin A | Herbaspirillum seropedicae SmR1
BGC0001189.5 |  | 0.21 | NRPS | taiwachelin | Cupriavidus taiwanensis LMG 19424
BGC0002571.2 |  | 0.21 | NRPS | pyoverdine DC3000 | Pseudomonas syringae pv. tomato str. DC3000
BGC0001721.3 |  | 0.21 | NRPS | ornibactin | Burkholderia cepacia

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.67 out of 26.06
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.80 out of 29.38
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.79 out of 30.25
Confidence: medium
Additional weak hits (2):
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.59 out of 29.25
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.74 out of 29.38
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ColR | Phenol-responsive regulator
FuR variant 1 | Ferric Uptake Regulator
MogR | Repressor of flagellar motility genes

NZ_CP016896.1 - Region 5 - NRP-metallophore,NRPS,t3nrps-iterative
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,825,933 - 1,881,842 nt. (total: 55,910 nt) Show pHMM detection rules used
t3nrps-iterative: (AMP-binding and PP-binding and (DUF98 or Orn_Arg_deC_N or Orn_DAP_Arg_deC) and not ATP-grasp)
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase oxygenase
BEN76_RS08785: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

BEN76_RS08795: oxidoreductase

smcogs
  SMCOG1083: oxidoreductase

BEN76_RS08800: acyl-CoA dehydrogenase type 2

smcogs
  SMCOG1191: acyl-CoA dehydrogenase type 2

BEN76_RS08850: lysine/ornithine N-monooxygenase

smcogs
  SMCOG1080: lysine/ornithine N-monooxygenase

BEN76_RS08875: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: PPTase
BEN76_RS08835: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1060: 4'-phosphopantetheinyl transferase

Hydrolases: esterase hydrolase
BEN76_RS08830: thioesterase

smcogs
  SMCOG1004: thioesterase

BEN76_RS08880: isochorismatase

smcogs
  SMCOG1027: isochorismatase

Lyases: decarboxylase
BEN76_RS08845: diaminopimelate decarboxylase

smcogs
  SMCOG1264: diaminopimelate decarboxylase

Isomerases: isomerase
BEN76_RS08885: isochorismate synthase

smcogs
  SMCOG1018: isochorismate synthase

Ligases: ligase
BEN76_RS08855: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

BEN76_RS08860: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

BEN76_RS08870: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

BEN76_RS17615: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | t3nrps-iterative | NRP-metallophore | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | ---
BGC0000352.5 |  |  |  | 1.33 | NRPS | fimsbactin A | Acinetobacter sp. ADP1
BGC0001128.4 |  |  |  | 0.91 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  |  |  | 0.91 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001132.4 |  |  |  | 0.90 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002286.3 |  |  |  | 0.90 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  |  |  | 0.87 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000307.4 |  |  |  | 0.86 | NRPS | AbT1 | Aureobasidium pullulans
BGC0002493.3 |  |  |  | 0.78 | NRPS | parabactin | Paracoccus denitrificans PD1222
BGC0000343.5 |  |  |  | 0.75 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0002474.2 |  |  |  | 0.73 | NRPS | agrobactin | Agrobacterium tumefaciens

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000352.5 |  | 0.77 | NRPS | fimsbactin A | Acinetobacter sp. ADP1
BGC0001128.4 |  | 0.64 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.64 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001132.4 |  | 0.64 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002286.3 |  | 0.63 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.63 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000307.4 |  | 0.62 | NRPS | AbT1 | Aureobasidium pullulans
BGC0002493.3 |  | 0.59 | NRPS | parabactin | Paracoccus denitrificans PD1222
BGC0002474.2 |  | 0.59 | NRPS | agrobactin | Agrobacterium tumefaciens
BGC0000343.5 |  | 0.59 | NRPS | enterobactin | Pseudomonas sp. J465

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.63 out of 18.46
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.38 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.93 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.71 out of 26.06
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.78 out of 29.38
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.60 out of 26.06
Confidence: medium
Additional weak hits (7):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.56 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.31 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.72 out of 32.74
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.43 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.57 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.23 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.72 out of 29.38
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 6, location 1825932 - 1881842:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Ser)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
BEN76_RS08855: diOH-Bz
Search NORINE for peptide: strict or relaxed
AMP-binding (42..446): diOH-Bz
nrpys: diOH-Bz

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Small clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Single AA prediction:
    dhb (diOH-Bz)

Stachelhaus prediction details:
  Stachelhaus sequence:
    SKSLFCMSSPGGSLQVGGAQQVYGMAEGLVNFTH
  Nearest Stachelhaus code(s):
    diOH-Bz CMPSQGVVNK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

BEN76_RS17615: Ser
Search NORINE for peptide: strict or relaxed
AMP-binding (458..858): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    VETTHDMSIFDACTNQGGDISIGGPTETTIWSIW
  Nearest Stachelhaus code(s):
    Ser DMFCNGIIWK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
MogR | Repressor of flagellar motility genes
RpoN | Regulator of nitrogen assimilation and virulence
ToxT | Regulator of MSHA biosynthesis

NZ_CP016896.1 - Region 6 - arylpolyene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,922,918 - 1,964,144 nt. (total: 41,227 nt) Show pHMM detection rules used
arylpolyene: (APE_KS1 or APE_KS2)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase reductase
BEN76_RS09170: alkyl hydroperoxide reductase subunit

smcogs
  SMCOG1176: alkyl hydroperoxide reductase subunit

BEN76_RS09255: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

BEN76_RS09330: alkyl hydroperoxide reductase/ Thiol specific

smcogs
  SMCOG1196: alkyl hydroperoxide reductase/ Thiol specific

Transferases: acetyltransferase acylase acyltransferase aminotransferase
BEN76_RS09230: acyltransferase 3

smcogs
  SMCOG1088: acyltransferase 3

BEN76_RS09260: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

BEN76_RS09285: GCN5-related N-acetyltransferase

smcogs
  SMCOG1111: GCN5-related N-acetyltransferase

BEN76_RS09320: aminotransferase class-III

smcogs
  SMCOG1013: aminotransferase class-III

Hydrolases: back translocase hydrolase
BEN76_RS09195: GTP-binding protein LepA

smcogs
  SMCOG1190: GTP-binding protein LepA

BEN76_RS09200: GTP-binding protein LepA

smcogs
  SMCOG1190: GTP-binding protein LepA

BEN76_RS09235: HAD-superfamily hydrolase, subfamily IA, variant

smcogs
  SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Ligases: synthase
BEN76_RS09220: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

BEN76_RS09300: Pseudouridine synthase

smcogs
  SMCOG1154: Pseudouridine synthase

BEN76_RS09315: 8-amino-7-oxononanoate synthase

smcogs
  SMCOG1109: 8-amino-7-oxononanoate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | arylpolyene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002276.2 |  | 0.57 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0000948.5 |  | 0.52 | other (other) | α-galactosylceramide | Bacteroides fragilis NCTC 9343
BGC0000866.5 |  | 0.50 | other (other) | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0001987.2 |  | 0.49 | PKS | koreenceine A, koreenceine B, koreenceine C, koreenceine D | Pseudomonas koreensis
BGC0000867.3 |  | 0.49 | other (other) | polyhydroxyalkanoic acids | Ectothiorhodospira shaposhnikovii
BGC0001917.4 |  | 0.47 | PKS | 5aTHQ-9i, 5aTHQ-9n, 5aTHQ-10a, STAMs-9i, STAMs-9n | Streptomyces nigrescens
BGC0000218.5 |  | 0.46 | PKS | doxorubicin | Streptomyces peucetius
BGC0002510.2 |  | 0.46 | PKS | youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4 | Streptomyces sp.
BGC0002052.3 |  | 0.45 | other (ectoine) | ectoine | Streptomyces sp.
BGC0000231.5 |  | 0.45 | PKS | griseusin A, griseusin B | Streptomyces griseus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002276.2 |  | 0.57 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0000948.5 |  | 0.52 | other (other) | α-galactosylceramide | Bacteroides fragilis NCTC 9343
BGC0000866.5 |  | 0.50 | other (other) | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0001987.2 |  | 0.49 | PKS | koreenceine A, koreenceine B, koreenceine C, koreenceine D | Pseudomonas koreensis
BGC0000867.3 |  | 0.49 | other (other) | polyhydroxyalkanoic acids | Ectothiorhodospira shaposhnikovii
BGC0001917.4 |  | 0.47 | PKS | 5aTHQ-9i, 5aTHQ-9n, 5aTHQ-10a, STAMs-9i, STAMs-9n | Streptomyces nigrescens
BGC0000218.5 |  | 0.46 | PKS | doxorubicin | Streptomyces peucetius
BGC0002510.2 |  | 0.46 | PKS | youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4 | Streptomyces sp.
BGC0002052.3 |  | 0.45 | other (ectoine) | ectoine | Streptomyces sp.
BGC0000231.5 |  | 0.45 | PKS | griseusin A, griseusin B | Streptomyces griseus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.06 out of 19.26
Confidence: strong
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.54 out of 26.33
Confidence: medium
Additional weak hits (6):
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.78 out of 30.25
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.78 out of 30.25
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.89 out of 39.62
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.88 out of 20.01
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.46 out of 39.62
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.02 out of 31.73
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS substrates
TFBS Finder
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
BEN76_RS09260: mal
PKS_AT (17..299): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 83.3%
  inactive: 62.5%
  Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 104.3
  Methoxymalonyl-CoA: 50.4
  inactive: 49.7
  Methylmalonyl-CoA: 46.3
  Propionyl-CoA: 26.3
  Ethylmalonyl-CoA: 24.1
  Acetyl-CoA: 18.5
  2-Methylbutyryl-CoA: 16.9
  CHC-CoA: 12.6
  trans-1,2-CPDA: 10.6
  fatty_acid: 0.0
  Isobutyryl-CoA: 0.0
  Benzoyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
CRP | Cyclic AMP receptor protein

NZ_CP016896.1 - Region 7 - NAPAA
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,492,125 - 2,526,117 nt. (total: 33,993 nt) Show pHMM detection rules used
NAPAA: (AMP-binding and TIGR02353)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: methyltransferase
BEN76_RS11905: methyltransferase

smcogs
  SMCOG1089: methyltransferase

Ligases: ligase
BEN76_RS11945: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NAPAA | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001135.5 |  | 0.60 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001833.4 |  | 0.59 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001641.4 |  | 0.59 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.59 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.59 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0002518.3 |  | 0.45 | NRPS | syringafactin A, syringafactin C | Pseudomonas sp. SZ57
BGC0001844.4 |  | 0.45 | NRPS | holrhizin A, holrhizin B, holrhizin C, holrhizin D | Paraburkholderia rhizoxinica HKI 454
BGC0001748.4 |  | 0.44 | NRPS, PKS | pseudospumigin A, pseudospumigin B, pseudospumigin C, pseudospumigin D, pseudospumigin E, pseudospumigin F | Nostoc sp. CENA543
BGC0000623.3 |  | 0.42 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000527.5 |  | 0.42 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001135.5 |  | 0.60 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001833.4 |  | 0.59 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001641.4 |  | 0.59 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.59 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.59 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0002518.3 |  | 0.45 | NRPS | syringafactin A, syringafactin C | Pseudomonas sp. SZ57
BGC0001844.4 |  | 0.45 | NRPS | holrhizin A, holrhizin B, holrhizin C, holrhizin D | Paraburkholderia rhizoxinica HKI 454
BGC0001748.4 |  | 0.44 | NRPS, PKS | pseudospumigin A, pseudospumigin B, pseudospumigin C, pseudospumigin D, pseudospumigin E, pseudospumigin F | Nostoc sp. CENA543
BGC0000623.3 |  | 0.42 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000527.5 |  | 0.42 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.36 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.28 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.54 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.52 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.82 out of 27.78
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.40 out of 27.55
Confidence: medium
Additional weak hits (8):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.19 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.82 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.75 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.77 out of 26.06
Confidence: weak
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.30 out of 25.88
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.80 out of 26.12
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.31 out of 30.22
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 23.77 out of 35.63
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 8, location 2492124 - 2526117:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
BEN76_RS11945: X
AMP-binding (29..417): X
nrpys: Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    FSEFFDMSFEEIHANLGGEFNTYGPTETTVTSSL
  Nearest Stachelhaus code(s):
    Lys DIESIGTVTK (65% 8Å match)
  Stachelhaus code match:
    70% (weak)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM | Regulator of nitrogen-fixation genes
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis

NZ_CP016896.1 - Region 8 - arylpolyene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,331,984 - 3,373,189 nt. (total: 41,206 nt) Show pHMM detection rules used
arylpolyene: (APE_KS1 or APE_KS2)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
BEN76_RS15830: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

BEN76_RS15880: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

Transferases: PPTase halogenase
BEN76_RS15810: conventional flavin-dependent halogenase

halogenases
  conventional flavin-dependent halogenase
smcogs
  SMCOG1119: halogenase

BEN76_RS15835: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

Ligases: ligase synthase
BEN76_RS15775: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

BEN76_RS15780: polyprenol-monophosphomannose synthase ppm1

smcogs
  SMCOG1123: polyprenol-monophosphomannose synthase ppm1

BEN76_RS15820: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | arylpolyene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002341.2 |  | 0.75 | other (other) | 3,5-dibromo-p-anisic acid | Planctomycetales bacterium 10988
BGC0002608.2 |  | 0.75 | NRPS, PKS | ochratoxin A | Aspergillus steynii
BGC0000836.5 |  | 0.55 | other (other) | APE Ec | Escherichia coli CFT073
BGC0002008.3 |  | 0.54 | other (other) | aryl polyenes | Xenorhabdus doucetiae
BGC0000840.5 |  | 0.48 | other (other) | xanthomonadin I | Xanthomonas oryzae pv. oryzae
BGC0002711.2 |  | 0.48 | PKS | nostovalerolactone, 9-dehydronostovalerolactone | Nostoc punctiforme PCC 73102
BGC0001987.2 |  | 0.48 | PKS | koreenceine A, koreenceine B, koreenceine C, koreenceine D | Pseudomonas koreensis
BGC0001917.4 |  | 0.46 | PKS | 5aTHQ-9i, 5aTHQ-9n, 5aTHQ-10a, STAMs-9i, STAMs-9n | Streptomyces nigrescens
BGC0002510.2 |  | 0.46 | PKS | youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4 | Streptomyces sp.
BGC0001366.5 |  | 0.45 | PKS | BE-24566B, zunyimycin A | Streptomyces sp. FJS31-2

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002341.2 |  | 0.75 | other (other) | 3,5-dibromo-p-anisic acid | Planctomycetales bacterium 10988
BGC0002608.2 |  | 0.75 | NRPS, PKS | ochratoxin A | Aspergillus steynii
BGC0000836.5 |  | 0.55 | other (other) | APE Ec | Escherichia coli CFT073
BGC0002008.3 |  | 0.54 | other (other) | aryl polyenes | Xenorhabdus doucetiae
BGC0000840.5 |  | 0.48 | other (other) | xanthomonadin I | Xanthomonas oryzae pv. oryzae
BGC0002711.2 |  | 0.48 | PKS | nostovalerolactone, 9-dehydronostovalerolactone | Nostoc punctiforme PCC 73102
BGC0001987.2 |  | 0.48 | PKS | koreenceine A, koreenceine B, koreenceine C, koreenceine D | Pseudomonas koreensis
BGC0001917.4 |  | 0.46 | PKS | 5aTHQ-9i, 5aTHQ-9n, 5aTHQ-10a, STAMs-9i, STAMs-9n | Streptomyces nigrescens
BGC0002510.2 |  | 0.46 | PKS | youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4 | Streptomyces sp.
BGC0001366.5 |  | 0.45 | PKS | BE-24566B, zunyimycin A | Streptomyces sp. FJS31-2

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.82 out of 21.84
Confidence: medium
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 24.14 out of 26.12
Confidence: medium
Additional weak hits (8):
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.08 out of 30.22
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 25.17 out of 33.73
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.33 out of 20.01
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.45 out of 29.25
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.67 out of 26.06
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.96 out of 33.14
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.51 out of 32.93
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.40 out of 26.06
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS substrates
TFBS Finder
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
BEN76_RS15775: X
AMP-binding (23..285): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    EGLVHIYGLLFLISFSSGGTEILGSSETGGIAFR
  Nearest Stachelhaus code(s):
  Stachelhaus code match:
    0% (weak)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
LuxO | Repressor of luminescence
MexT | Global virulence regulator
ToxT | Regulator of MSHA biosynthesis

NZ_CP016898.1 - Region 1 - lassopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
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Location: 9,886 - 32,188 nt. (total: 22,303 nt) Show pHMM detection rules used
lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lasso peptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lassopeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002322.3 |  | 0.51 | ribosomal | citrocin | Citrobacter pasteurii
BGC0001639.3 |  | 0.50 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0002312.2 |  | 0.47 | ribosomal | ubonodin | Burkholderia ubonensis
BGC0000572.5 |  | 0.44 | ribosomal | capistruin | Burkholderia thailandensis E444
BGC0000581.6 |  | 0.44 | ribosomal | microcin J25 | Escherichia coli AY25
BGC0000486.4 |  | 0.40 | ribosomal | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0000616.4 |  | 0.40 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0000517.4 |  | 0.37 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0002825.2 |  | 0.37 | ribosomal | nocapeptin A | Nocardia terpenica IFM 0406
BGC0001229.4 |  | 0.36 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002322.3 |  | 0.51 | ribosomal | citrocin | Citrobacter pasteurii
BGC0001639.3 |  | 0.50 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0002312.2 |  | 0.47 | ribosomal | ubonodin | Burkholderia ubonensis
BGC0000572.5 |  | 0.44 | ribosomal | capistruin | Burkholderia thailandensis E444
BGC0000581.6 |  | 0.44 | ribosomal | microcin J25 | Escherichia coli AY25
BGC0000486.4 |  | 0.40 | ribosomal | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0000616.4 |  | 0.40 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0000517.4 |  | 0.37 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0002825.2 |  | 0.37 | ribosomal | nocapeptin A | Nocardia terpenica IFM 0406
BGC0001229.4 |  | 0.36 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lasso peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Each core peptide shows the leader and core peptide sequences.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lassopeptide(s) for BEN76_RS17395

BEN76_RS17395
Leader:
MNNLKQNVKTEIEKKQKLQVISVKGSASKMTL
Full core:
G G K G P L P E Y F L M G G G G N F Y G
Putative macrolactam:
G G K G P L P E

#### antiSMASH-DB 4.0 matches for BEN76_RS17395

100.0%
NZ_CP016898.1:
Lassopeptides: BEN76_RS17395_lassopeptide
1
G G K G P L P E Y F L M G G G G N F Y G
20
G G K G P L P E Y F L M G G G G N F Y G
1
G G K G P L P E Y F L M G G G G N F Y G
20
52.4%
NZ_AP021947.1 and 16 others:
NZ_CAJGEM010000015.1 Lassopeptides: JMT87_RS21655_lassopeptide NZ_CAJGGU010000008.1 Lassopeptides: JMU20_RS21490_lassopeptide NZ_CP010127.1 Lassopeptides: RG30_RS26380_lassopeptide NZ_CP031107.1 Lassopeptides: DUT84_RS26055_lassopeptide NZ_CP074577.1 Lassopeptides: KHZ70_RS24010_lassopeptide NZ_CP091672.1 Lassopeptides: L6L68_RS00080_lassopeptide NZ_CP097722.1 Lassopeptides: M9O79_RS23190_lassopeptide NZ_CP117571.1 Lassopeptides: PS035_RS23020_lassopeptide NZ_CP117612.1 Lassopeptides: PS038_RS23585_lassopeptide NZ_CP117622.1 Lassopeptides: PS039_RS24320_lassopeptide NZ_FZFT01000070.1 Lassopeptides: CPG75_RS26760_lassopeptide NZ_JABMLY010000084.1 Lassopeptides: HRQ70_RS23615_lassopeptide NZ_JZNY01000005.1 Lassopeptides: VE51_RS00690_lassopeptide NZ_JZOJ01000049.1 Lassopeptides: VE62_RS06215_lassopeptide NZ_MRDN01000066.1 Lassopeptides: BSF34_RS29250_lassopeptide NZ_OW968329.1 Lassopeptides: LQ108_RS23255_lassopeptide
Lassopeptides: H7R07_RS25795_lassopeptide
1
G G K G P L P E Y F L-M G G G G N F Y G
20
G G G +P E Y F+ +G +F Y G
1
G G A G H V P E Y F V G I G T P I S F Y G
21
50.0%
NZ_KI530699.1:
Lassopeptides: F987_RS22525_lassopeptide
1
G G K G P L P E Y F L M G G G G N F Y G
20
G G K G P+ E ++ G N+Y G
1
G G K G P I F E T W V T--E G N Y Y G
18
with 8 more sequence matches
26.9%
NZ_VYKJ01000032.1:
Lassopeptides: FJU30_RS26370_lassopeptide
1
G G K G P L P E Y F
10
G G G +P E Y F
1
G G D G G I P E Y F
10
24.2%
NC_014925.1 and 18 others:
NZ_ANOI01000001.1 Sactipeptides: F779_RS13290_sactipeptide NZ_CP031604.1 Sactipeptides: DNJ55_RS07055_sactipeptide NZ_CP031605.1 Sactipeptides: DRC71_RS00165_sactipeptide NZ_CP035741.1 Sactipeptides: EW136_RS01865_sactipeptide NZ_CP039747.1 Sactipeptides: EFT29_RS00935_sactipeptide NZ_CP054206.2 Sactipeptides: HP560_RS11995_sactipeptide NZ_CP060700.1 Sactipeptides: H9Q12_RS10940_sactipeptide NZ_CP065920.1 Sactipeptides: JC281_RS11580_sactipeptide NZ_CP066885.1 Sactipeptides: JGZ27_RS11325_sactipeptide NZ_CP076465.1 Sactipeptides: KDE16_RS00560_sactipeptide NZ_JANPRJ010000013.1 Sactipeptides: NVR03_RS10250_sactipeptide NZ_JANPRN010000039.1 Sactipeptides: NVR04_RS07875_sactipeptide NZ_JTKO01000012.1 Sactipeptides: NO87_RS10650_sactipeptide NZ_LR134267.1 Sactipeptides: EL085_RS11430_sactipeptide NZ_MQMO01000006.1 Sactipeptides: BSR38_RS07375_sactipeptide NZ_MQNF01000024.1 Sactipeptides: BSR36_RS12515_sactipeptide NZ_QQPJ01000025.1 Sactipeptides: DV949_RS11300_sactipeptide NZ_SEZW01000001.1 Sactipeptides: EWV33_RS08610_sactipeptide
Sactipeptides: SPSINT_RS00615_sactipeptide
3
K G P L P E Y F L M G G G G N F
18
G P L P++ +M G G F
14
D G P L P D F E V M G I T G I F
29
21.2%
NZ_CP027770.1:
Sactipeptides: C7J90_RS04260_sactipeptide
3
K G P L P E Y F L M G G G G N F
18
G P P++ +M G G F
14
D G P F P D F E V M G I T G T F
29
21.2%
NZ_CP066713.1:
Sactipeptides: JGZ50_RS11620_sactipeptide
3
K G P L P E Y F L M G G G G N F Y
19
G P L P++ G N F+
13
D G P L P D F R S H G N Y W N F W
29
18.2%
NC_000964.3 and 236 others:
NC_014479.1 Sactipeptides: BSUW23_RS18740_sactipeptide NC_014639.1 Sactipeptides: BATR1942_RS15950_sactipeptide NC_014976.1 Sactipeptides: BSN5_RS09700_sactipeptide NC_016047.1 Sactipeptides: GYO_RS41165_sactipeptide NC_017195.1 Sactipeptides: I33_RS18040_sactipeptide NC_017743.1 Sactipeptides: MY9_RS18920_sactipeptide NC_019896.1 Sactipeptides: A7A1_RS01935_sactipeptide NC_020244.1 Sactipeptides: C663_RS18295_sactipeptide NZ_BDDH01000003.1 Sactipeptides: A7P71_RS10610_sactipeptide NZ_CABIVP010000002.1 Sactipeptides: FY199_RS09010_sactipeptide NZ_CP007409.1 Sactipeptides: Q433_RS18950_sactipeptide NZ_CP009796.1 Sactipeptides: OB04_RS19085_sactipeptide NZ_CP011101.1 Sactipeptides: bslm_RS18365_sactipeptide NZ_CP011534.1 Sactipeptides: ABA10_RS18725_sactipeptide NZ_CP011802.1 Sactipeptides: D068_RS17505_sactipeptide NZ_CP016767.1 Sactipeptides: BCV50_RS14935_sactipeptide NZ_CP017072.1 Sactipeptides: BGM23_RS02945_sactipeptide NZ_CP017112.1 Sactipeptides: BS16045_RS19810_sactipeptide NZ_CP017313.1 Sactipeptides: BH660_RS14630_sactipeptide NZ_CP017314.1 Sactipeptides: BSBS38_RS19215_sactipeptide NZ_CP017676.1 Sactipeptides: BKN48_RS08085_sactipeptide NZ_CP018173.1 Sactipeptides: BAX60_RS03615_sactipeptide NZ_CP020367.1 Sactipeptides: BSK2_RS19060_sactipeptide NZ_CP020722.1 Sactipeptides: B7470_RS09560_sactipeptide NZ_CP020915.1 Sactipeptides: B9L64_RS11255_sactipeptide NZ_CP021169.1 Sactipeptides: B9N48_RS18685_sactipeptide NZ_CP021498.1 Sactipeptides: S101444_RS19170_sactipeptide NZ_CP021892.1 Sactipeptides: S100333_RS19720_sactipeptide NZ_CP021903.1 Sactipeptides: CD007_RS18975_sactipeptide NZ_CP021911.1 Sactipeptides: CDO84_RS18225_sactipeptide NZ_CP021921.1 Sactipeptides: S101392_RS19440_sactipeptide NZ_CP022391.1 Sactipeptides: CFK25_RS18875_sactipeptide NZ_CP022890.1 Sactipeptides: CJZ70_RS01210_sactipeptide NZ_CP023257.1 Sactipeptides: CLD04_RS19470_sactipeptide NZ_CP023409.1 Sactipeptides: Bateq7PJ16_RS20450_sactipeptide NZ_CP025941.1 Sactipeptides: C0W65_RS07300_sactipeptide NZ_CP026010.1 Sactipeptides: BS11774_RS03710_sactipeptide NZ_CP026030.1 Sactipeptides: C2H91_RS12110_sactipeptide NZ_CP026035.1 Sactipeptides: C2H96_RS13375_sactipeptide NZ_CP026036.1 Sactipeptides: C2H93_RS16885_sactipeptide NZ_CP026521.1 Sactipeptides: C1T29_RS22385_sactipeptide NZ_CP028201.1 Sactipeptides: C7M16_RS17535_sactipeptide NZ_CP028202.1 Sactipeptides: C7M17_RS17600_sactipeptide NZ_CP028217.1 Sactipeptides: C7M29_RS06900_sactipeptide NZ_CP028218.1 Sactipeptides: C7M30_RS12605_sactipeptide NZ_CP028812.1 Sactipeptides: DAE22_RS20770_sactipeptide NZ_CP029364.1 Sactipeptides: DIC78_RS12275_sactipeptide NZ_CP029461.1 Sactipeptides: DJ572_RS18795_sactipeptide NZ_CP029465.1 Sactipeptides: DKG76_RS19825_sactipeptide NZ_CP029609.1 Sactipeptides: DL538_RS20030_sactipeptide NZ_CP031675.1 Sactipeptides: DYS67_RS19275_sactipeptide NZ_CP031783.1 Sactipeptides: D0808_RS00710_sactipeptide NZ_CP031784.1 Sactipeptides: D0819_RS14700_sactipeptide NZ_CP032853.1 Sactipeptides: D9C10_RS17955_sactipeptide NZ_CP032855.1 Sactipeptides: D9C11_RS09165_sactipeptide NZ_CP035161.1 Sactipeptides: EQH88_RS19675_sactipeptide NZ_CP035167.1 Sactipeptides: EQJ08_RS19095_sactipeptide NZ_CP035226.1 Sactipeptides: EQW70_RS20085_sactipeptide NZ_CP035231.1 Sactipeptides: EQZ01_RS19685_sactipeptide NZ_CP035391.1 Sactipeptides: ES965_RS19370_sactipeptide NZ_CP035395.1 Sactipeptides: ES968_RS19740_sactipeptide NZ_CP035401.1 Sactipeptides: ETA19_RS19595_sactipeptide NZ_CP035402.1 Sactipeptides: ES969_RS19660_sactipeptide NZ_CP035403.1 Sactipeptides: ETA15_RS19805_sactipeptide NZ_CP035406.1 Sactipeptides: ETK61_RS20735_sactipeptide NZ_CP035413.1 Sactipeptides: ETL58_RS19505_sactipeptide NZ_CP039935.1 Sactipeptides: FCJ76_RS19255_sactipeptide NZ_CP045006.1 Sactipeptides: F9B13_RS01950_sactipeptide NZ_CP045425.1 Sactipeptides: GCU76_RS20710_sactipeptide NZ_CP045816.1 Sactipeptides: GII86_RS19920_sactipeptide NZ_CP045824.1 Sactipeptides: GII78_RS20125_sactipeptide NZ_CP046591.1 Sactipeptides: GO004_RS15965_sactipeptide NZ_CP046860.1 Sactipeptides: GPJ55_RS11605_sactipeptide NZ_CP047645.1 Sactipeptides: GSN02_RS19265_sactipeptide NZ_CP049924.1 Sactipeptides: G4G26_RS18960_sactipeptide NZ_CP050705.1 Sactipeptides: HCU65_RS18920_sactipeptide NZ_CP051462.1 Sactipeptides: HC662_RS19240_sactipeptide NZ_CP051464.1 Sactipeptides: HC660_RS18970_sactipeptide NZ_CP054050.1 Sactipeptides: HNV25_RS02005_sactipeptide NZ_CP054177.1 Sactipeptides: HR084_RS18935_sactipeptide NZ_CP054584.1 Sactipeptides: HT135_RS19775_sactipeptide NZ_CP060193.1 Sactipeptides: H7F27_RS02180_sactipeptide NZ_CP060417.1 Sactipeptides: H8S71_RS18495_sactipeptide NZ_CP061284.1 Sactipeptides: ICJ61_RS19715_sactipeptide NZ_CP061870.1 Sactipeptides: IE382_RS22305_sactipeptide NZ_CP062497.1 Sactipeptides: IHV08_RS19770_sactipeptide NZ_CP063276.1 Sactipeptides: IM743_RS18070_sactipeptide NZ_CP065858.1 Sactipeptides: I7X10_RS03370_sactipeptide NZ_CP069789.1 Sactipeptides: JR441_RS19085_sactipeptide NZ_CP070483.1 Sactipeptides: JQX68_RS19175_sactipeptide NZ_CP070976.1 Sactipeptides: JYG31_RS19675_sactipeptide NZ_CP071043.1 Sactipeptides: JS609_RS19245_sactipeptide NZ_CP073265.1 Sactipeptides: KCX77_RS18900_sactipeptide NZ_CP075344.1 Sactipeptides: KIL00_RS20100_sactipeptide NZ_CP076083.1 Sactipeptides: KFF76_RS18635_sactipeptide NZ_CP079759.1 Sactipeptides: KXZ66_RS19695_sactipeptide NZ_CP080508.1 Sactipeptides: K0V03_RS08595_sactipeptide NZ_CP089148.1 Sactipeptides: LRO88_RS20980_sactipeptide NZ_CP090125.1 Sactipeptides: LXE94_RS19505_sactipeptide NZ_CP092751.1 Sactipeptides: MKF32_RS18515_sactipeptide NZ_CP093289.1 Sactipeptides: MNG38_RS19730_sactipeptide NZ_CP093546.1 Sactipeptides: MOW04_RS19180_sactipeptide NZ_CP095736.1 Sactipeptides: MX663_RS20090_sactipeptide NZ_CP096590.1 Sactipeptides: M0696_RS18995_sactipeptide NZ_CP096889.1 Sactipeptides: EFK13_RS19225_sactipeptide NZ_CP098738.1 Sactipeptides: NDR85_RS18965_sactipeptide NZ_CP100651.1 Sactipeptides: NLW79_RS19990_sactipeptide NZ_CP100752.1 Sactipeptides: NLV76_RS19060_sactipeptide NZ_CP101718.1 Sactipeptides: NPA28_RS19075_sactipeptide NZ_CP101936.1 Sactipeptides: NP434_RS18980_sactipeptide NZ_CP103352.1 Sactipeptides: NX823_RS19780_sactipeptide NZ_CP104878.1 Sactipeptides: N8A75_RS20105_sactipeptide NZ_CP107539.1 Sactipeptides: OEG95_RS19105_sactipeptide NZ_CP110264.1 Sactipeptides: OMK57_RS18975_sactipeptide NZ_CP114899.1 Sactipeptides: O6U12_RS19480_sactipeptide NZ_CP116773.1 Sactipeptides: PNF29_RS01990_sactipeptide NZ_FTMW01000001.1 Sactipeptides: BW968_RS02045_sactipeptide NZ_JAAUXF010000005.1 Sactipeptides: HC742_RS19325_sactipeptide NZ_JABRUZ010000003.1 Sactipeptides: HRF55_RS03085_sactipeptide NZ_JABRVH010000018.1 Sactipeptides: HRF53_RS09100_sactipeptide NZ_JABUKD010000002.1 Sactipeptides: HRW04_RS09345_sactipeptide NZ_JAEACL010000001.1 Sactipeptides: I5F14_RS00800_sactipeptide NZ_JAHVOC010000002.1 Sactipeptides: KXD37_RS07830_sactipeptide NZ_JAJFDG010000003.1 Sactipeptides: LJF29_RS11575_sactipeptide NZ_JAJHUI010000011.1 Sactipeptides: LK399_RS16325_sactipeptide NZ_JALAJC010000012.1 Sactipeptides: MOB18_RS16080_sactipeptide NZ_JALAKW010000005.1 Sactipeptides: MOB93_RS12665_sactipeptide NZ_JALAKZ010000001.1 Sactipeptides: MOB76_RS02240_sactipeptide NZ_JALALA010000011.1 Sactipeptides: MOB82_RS15020_sactipeptide NZ_JALALE010000020.1 Sactipeptides: MOB33_RS20855_sactipeptide NZ_JALALO010000006.1 Sactipeptides: MOB75_RS09230_sactipeptide NZ_JALAMD010000002.1 Sactipeptides: MOB22_RS02315_sactipeptide NZ_JALAME010000005.1 Sactipeptides: MOC02_RS13805_sactipeptide NZ_JALAMJ010000012.1 Sactipeptides: MOB80_RS16635_sactipeptide NZ_JALAMO010000007.1 Sactipeptides: MOB98_RS08535_sactipeptide NZ_JALAMR010000019.1 Sactipeptides: MOC09_RS17975_sactipeptide NZ_JALAMZ010000002.1 Sactipeptides: MOC43_RS01370_sactipeptide NZ_JALANN010000012.1 Sactipeptides: MOC49_RS18290_sactipeptide NZ_JALANX010000001.1 Sactipeptides: MOC25_RS03365_sactipeptide NZ_JALAPT010000001.1 Sactipeptides: MOC95_RS01580_sactipeptide NZ_JALAPV010000005.1 Sactipeptides: MOC91_RS13515_sactipeptide NZ_JALAPW010000003.1 Sactipeptides: MOD18_RS06235_sactipeptide NZ_JALAPX010000003.1 Sactipeptides: MOC97_RS06805_sactipeptide NZ_JALAPZ010000002.1 Sactipeptides: MOC81_RS03830_sactipeptide NZ_JALAQA010000008.1 Sactipeptides: MOD07_RS14955_sactipeptide NZ_JALAQC010000001.1 Sactipeptides: MOD00_RS01290_sactipeptide NZ_JALAQD010000002.1 Sactipeptides: MOD08_RS05770_sactipeptide NZ_JALAQE010000002.1 Sactipeptides: MOD19_RS04725_sactipeptide NZ_JALASB010000002.1 Sactipeptides: MOD42_RS03685_sactipeptide NZ_JALASC010000024.1 Sactipeptides: MOD69_RS20580_sactipeptide NZ_JALASM010000006.1 Sactipeptides: MOD51_RS10970_sactipeptide NZ_JALASR010000006.1 Sactipeptides: MOD87_RS10780_sactipeptide NZ_JALAST010000011.1 Sactipeptides: MOE17_RS14670_sactipeptide NZ_JALASW010000005.1 Sactipeptides: MOE15_RS06925_sactipeptide NZ_JALATC010000001.1 Sactipeptides: MOD56_RS03380_sactipeptide NZ_JALATD010000001.1 Sactipeptides: MOE02_RS03350_sactipeptide NZ_JALATE010000006.1 Sactipeptides: MOD98_RS11440_sactipeptide NZ_JALATF010000003.1 Sactipeptides: MOD44_RS09960_sactipeptide NZ_JALATG010000002.1 Sactipeptides: MOE16_RS03490_sactipeptide NZ_JALATJ010000007.1 Sactipeptides: MOD90_RS15770_sactipeptide NZ_JALATU010000001.1 Sactipeptides: MOE27_RS01985_sactipeptide NZ_JALATV010000005.1 Sactipeptides: MOD97_RS07020_sactipeptide NZ_JALAUA010000008.1 Sactipeptides: MOD32_RS16030_sactipeptide NZ_JALAUD010000001.1 Sactipeptides: MOE28_RS03345_sactipeptide NZ_JALAUJ010000006.1 Sactipeptides: MOE37_RS12685_sactipeptide NZ_JALAUK010000012.1 Sactipeptides: MOE38_RS11825_sactipeptide NZ_JALAUV010000003.1 Sactipeptides: MOE71_RS06545_sactipeptide NZ_JALAUW010000015.1 Sactipeptides: MOE83_RS13210_sactipeptide NZ_JALAVA010000002.1 Sactipeptides: MOE81_RS02625_sactipeptide NZ_JALAVE010000001.1 Sactipeptides: MOE67_RS03645_sactipeptide NZ_JALAVI010000011.1 Sactipeptides: MOE80_RS14660_sactipeptide NZ_JALAVK010000006.1 Sactipeptides: MOE96_RS10120_sactipeptide NZ_JALAVL010000002.1 Sactipeptides: MOE60_RS03290_sactipeptide NZ_JALAVM010000009.1 Sactipeptides: MOE49_RS16195_sactipeptide NZ_JALAVO010000008.1 Sactipeptides: MOE63_RS14665_sactipeptide NZ_JALAVQ010000003.1 Sactipeptides: MOE59_RS02420_sactipeptide NZ_JALAVS010000002.1 Sactipeptides: MOE46_RS02250_sactipeptide NZ_JALAVT010000005.1 Sactipeptides: MOF25_RS08325_sactipeptide NZ_JALAVU010000004.1 Sactipeptides: MOE78_RS09660_sactipeptide NZ_JALAVV010000004.1 Sactipeptides: MOE66_RS02855_sactipeptide NZ_JALAVW010000001.1 Sactipeptides: MOE86_RS01005_sactipeptide NZ_JALAVX010000009.1 Sactipeptides: MOE40_RS07525_sactipeptide NZ_JALAVZ010000002.1 Sactipeptides: MOF00_RS02525_sactipeptide NZ_JALAWB010000008.1 Sactipeptides: MOE87_RS15020_sactipeptide NZ_JALAWK010000002.1 Sactipeptides: MOF06_RS12140_sactipeptide NZ_JALAWW010000010.1 Sactipeptides: MOF23_RS17300_sactipeptide NZ_JALAXQ010000012.1 Sactipeptides: MOF24_RS14120_sactipeptide NZ_JALAXV010000001.1 Sactipeptides: MOF15_RS00375_sactipeptide NZ_JALAYA010000016.1 Sactipeptides: MOF34_RS08915_sactipeptide NZ_JALAYD010000019.1 Sactipeptides: MOF39_RS20725_sactipeptide NZ_JALNTO010000006.1 Sactipeptides: MTN95_RS11045_sactipeptide NZ_JAMDFN010000008.1 Sactipeptides: M3M31_RS18245_sactipeptide NZ_JAMYDW010000003.1 Sactipeptides: NHM07_RS10830_sactipeptide NZ_JANBMP010000002.1 Sactipeptides: NL430_RS07940_sactipeptide NZ_JANDGG010000001.1 Sactipeptides: NKU38_RS03365_sactipeptide NZ_JANFAP010000001.1 Sactipeptides: NEC81_RS02065_sactipeptide NZ_JAQFFE010000015.1 Sactipeptides: PG051_RS13540_sactipeptide NZ_JAQOXM010000001.1 Sactipeptides: PO770_RS01950_sactipeptide NZ_JH600279.1 Sactipeptides: GYU_RS0104160_sactipeptide NZ_JXHL01000020.1 Sactipeptides: B4069_RS07025_sactipeptide NZ_JXHP01000031.1 Sactipeptides: B4073_RS09425_sactipeptide NZ_JXHR01000010.1 Sactipeptides: B4146_RS06925_sactipeptide NZ_KZ848487.1 Sactipeptides: DSL71_RS14015_sactipeptide NZ_LPVE01000021.1 Sactipeptides: AU385_RS06600_sactipeptide NZ_LSBB01000001.1 Sactipeptides: AXI57_RS01770_sactipeptide NZ_LUUT01000004.1 Sactipeptides: A6751_RS18460_sactipeptide NZ_MOEO01000004.1 Sactipeptides: BLL41_RS09830_sactipeptide NZ_MUXL01000002.1 Sactipeptides: B0W20_RS08845_sactipeptide NZ_MZZI01000001.1 Sactipeptides: B2G85_RS18515_sactipeptide NZ_NBBO01000003.1 Sactipeptides: B6K89_RS01830_sactipeptide NZ_NERK01000024.1 Sactipeptides: B9T64_RS18540_sactipeptide NZ_NJRD01000003.1 Sactipeptides: CE053_RS09115_sactipeptide NZ_NJRE01000002.1 Sactipeptides: CE047_RS07205_sactipeptide NZ_NKAK01000003.1 Sactipeptides: CE489_RS10400_sactipeptide NZ_NMOM01000004.1 Sactipeptides: CFI07_RS07245_sactipeptide NZ_PHIE01000002.1 Sactipeptides: CVV77_RS10760_sactipeptide NZ_PJCT01000002.1 Sactipeptides: CW370_RS11825_sactipeptide NZ_PVQM01000002.1 Sactipeptides: C6W22_RS11490_sactipeptide NZ_PVQN01000002.1 Sactipeptides: C6W23_RS05885_sactipeptide NZ_PVRK01000001.1 Sactipeptides: C6350_RS02025_sactipeptide NZ_PVWC01000004.1 Sactipeptides: C6372_RS11675_sactipeptide NZ_QRFZ01000012.1 Sactipeptides: DXT72_RS19010_sactipeptide NZ_SDKE01000003.1 Sactipeptides: EUA35_RS12130_sactipeptide NZ_SHOB01000002.1 Sactipeptides: ES060_RS14270_sactipeptide NZ_SIRN01000006.1 Sactipeptides: EYH65_RS15720_sactipeptide NZ_SNWK01000001.1 Sactipeptides: DFO69_RS02055_sactipeptide NZ_SOBO01000012.1 Sactipeptides: DFO78_RS18210_sactipeptide NZ_SORJ01000001.1 Sactipeptides: BJ795_RS03350_sactipeptide NZ_VBRP01000025.1 Sactipeptides: FE220_RS07065_sactipeptide NZ_VFNF01000001.1 Sactipeptides: FB592_RS03405_sactipeptide NZ_VIOH01000001.1 Sactipeptides: FLN47_RS01935_sactipeptide NZ_VLJK01000012.1 Sactipeptides: L605_RS10195_sactipeptide NZ_VLJL01000006.1 Sactipeptides: L604_RS05585_sactipeptide NZ_VLJX01000001.1 Sactipeptides: L609_RS01950_sactipeptide NZ_VTEK01000003.1 Sactipeptides: FZC71_RS10310_sactipeptide NZ_WTKJ01000004.1 Sactipeptides: NWT17_RS06185_sactipeptide
Sactipeptides: BSU_37350_sactipeptide
3
K G P L P E Y F L M G G G G N F
18
G P+P++ + G G F
14
D G P I P D F E I A G A T G L F
29
18.2%
NZ_ATDF02000020.1 and 7 others:
NZ_CP063367.1 Sactipeptides: IPU22_RS12430_sactipeptide NZ_CP094808.1 Sactipeptides: MUA11_RS01375_sactipeptide NZ_CP094809.1 Sactipeptides: MUA95_RS01320_sactipeptide NZ_CP094813.1 Sactipeptides: MUA84_RS01300_sactipeptide NZ_KV827785.1 Sactipeptides: HMPREF2580_RS10900_sactipeptide NZ_LR134263.1 Sactipeptides: EL101_RS12790_sactipeptide NZ_VKCY01000004.1 Sactipeptides: FNK43_RS05155_sactipeptide
Sactipeptides: M462_RS08950_sactipeptide
2
G K G P L P E Y F L M G G G G N F
18
G P+P++ + G G F
13
A D G P I P D F E V A G I T G T F
29
18.2%
NZ_CP048852.1:
Sactipeptides: G4P54_RS19300_sactipeptide
3
K G P L P E Y F L M G G G G N F
18
G P+P++ + G G F
14
D G P I P D F E V A G A T G L F
29
15.2%
NC_022584.1 and 2 others:
NZ_CP047883.1 Sactipeptides: M594_RS05585_sactipeptide NZ_KV802690.1 Sactipeptides: HMPREF2764_RS03300_sactipeptide
Sactipeptides: N596_RS03165_sactipeptide
2
G K G P L P E Y F L M G G G G N F Y G
20
G P+P++ + G F
13
A D G P I P D F E I A G V S A V F T A
31

#### MIBiG 4.0 matches for BEN76_RS17395

52.4%
BGC0000581.6 (AAD28494.1):
Lasso peptide: microcin J25
1
G G K G P L P E Y F L-M G G G G N F Y G
20
G G G +P E Y F+ +G +F Y G
1
G G A G H V P E Y F V G I G T P I S F Y G
21
25.0%
BGC0001639.3 (OUH62395.1):
Lasso peptide: klebsidin
1
G G K G P L P E Y F
10
G G P+ E+F
1
G S D G P I I E F F
10

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 26.94 out of 27.78
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.92 out of 27.78
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.94 out of 21.55
Confidence: medium
Additional weak hits (2):
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.27 out of 25.75
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.90 out of 28.14
Confidence: weak
Lasso peptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of disulfide bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

BEN76_RS17395 - Class II
  Cleavage pHMM score: -0.20
  RODEO score: 25
  Monoisotopic mass: 1998.9 Da
  Molecular weight: 2000.2 Da
  Number of bridges: 0

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria