LOCUS       NZ_LIYH01000004        22337 bp    DNA     linear   CON 28-MAR-2024
DEFINITION  Streptomyces sp. CB03234 scaffold4, whole genome shotgun sequence.
ACCESSION   NZ_LIYH01000004
VERSION     NZ_LIYH01000004.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CB03234
  ORGANISM  Streptomyces sp. CB03234
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 931391)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 931391)
  AUTHORS   Yan,X., Ge,H., Hindra,F., Yang,D., Huang,T., Crnovcic,I. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-SEP-2015) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2015
            Assembly Method                   :: CLC Genomics Workbench v. 7.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905885.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:52:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,127
            CDSs (total)                      :: 7,053
            Genes (coding)                    :: 6,894
            CDSs (with protein)               :: 6,894
            Genes (RNA)                       :: 74
            rRNAs                             :: 2, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 159
            CDSs (without protein)            :: 159
            Pseudo Genes (ambiguous residues) :: 0 of 159
            Pseudo Genes (frameshifted)       :: 70 of 159
            Pseudo Genes (incomplete)         :: 112 of 159
            Pseudo Genes (internal stop)      :: 10 of 159
            Pseudo Genes (multiple problems)  :: 33 of 159
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:29:50
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 758042
            Orig. end                         :: 780379
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LIYH01000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22337
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="6"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22337
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22337
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12337](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12337)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    30..43
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.99"
                     /tool="antismash"
     misc_feature    complement(30..44)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.12"
                     /tool="antismash"
     misc_feature    40..54
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     misc_feature    complement(226..235)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     misc_feature    complement(270..284)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.19"
                     /tool="antismash"
     gene            complement(643..1200)
                     /locus_tag="AMK26_RS20460"
                     /old_locus_tag="AMK26_20185"
     CDS             complement(643..1200)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018515051.1"
                     /locus_tag="AMK26_RS20460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_20185"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_079277701.1"
                     /transl_table=11
                     /translation="MSSHMTGRGTAGRPGTWPVRIRRATAGDAKRLTALVRNSRAYEGP
                     YAPMVAGYRVGPDYIDAHEVHVAAGDDGRVLGFYALVLSPPELDLMFVADTAQGLGVGR
                     TLVAHMSERARAAGVTAVRVVSHPPAEGFYRSVGARRVGTVNANPPAVMWDRPELVIAV
                     QNPSSRRTARNSAGLGGGLTSP"
     gene            complement(1247..2863)
                     /locus_tag="AMK26_RS20465"
                     /old_locus_tag="AMK26_20190"
     CDS             complement(1247..2863)
                     /NRPS_PKS="Domain: AMP-binding (8-435). E-value: 1.9e-67.
                     Score: 219.5. Matches aSDomain:
                     nrpspksdomains_AMK26_RS20465_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015662883.1"
                     /locus_tag="AMK26_RS20465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_20190"
                     /product="acyl-CoA synthetase"
                     /protein_id="WP_073756115.1"
                     /sec_met_domain="AMP-binding (E-value: 3.1e-73, bitscore:
                     242.3, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFNLADLFESVVDVVPDREALVYVDHPGTGAERRLTYAELDAAA
                     NRVGHHLLGAGLRPGEHVGLHLYNGVEYLQTVLGCLKARLVPVNVNYRYVEEELVYLYR
                     DADLAGLVFDAEFTGRVAAALPKTERLRHLVRVGAAAEGGPGLAFTDAEADGSPERGFG
                     PRSGDDLFIIYTGGTTGMPKGVMWRQEDLFFSGLGGGAPTGEPVKSPEELAERVAAGGE
                     GITFFPTPPLMHGTSTLTAFIGFNFGQRVVLHRKFVPHEVLRTIEKEKVTSVSLVGDAM
                     LRPLIDALGGPLKGIDLSSLFSVSSSGAIMSETVREQFLALVPHVMLLNNFGSSESGFN
                     GTATEDSGSDKGFRLRVNGRTQVVDPATYEPVTPGEVGRIAQRGHVPLGYYNDPAKTAE
                     TFFRRGDERWVLLGDMATVDEEGIVTVLGRGSQCINTGGEKVYPEEVEQALKSHPDVYD
                     ALVAGVPDPRWGHHVAAVVQLRAGAARPSLDDIQGHCRTRLAGYKVPRRLVITDRIQRS
                     PSGKADYRWARSVAAADAEPR"
     aSDomain        complement(1559..2839)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMK26_RS20465_AMP-binding.1"
                     /evalue="1.90E-67"
                     /label="AMK26_RS20465_AMP-binding.1"
                     /locus_tag="AMK26_RS20465"
                     /protein_end="435"
                     /protein_start="8"
                     /score="219.5"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FESVVDVVPDREALVYVDHPGTGAERRLTYAELDAAANRVGHHLL
                     GAGLRPGEHVGLHLYNGVEYLQTVLGCLKARLVPVNVNYRYVEEELVYLYRDADLAGLV
                     FDAEFTGRVAAALPKTERLRHLVRVGAAAEGGPGLAFTDAEADGSPERGFGPRSGDDLF
                     IIYTGGTTGMPKGVMWRQEDLFFSGLGGGAPTGEPVKSPEELAERVAAGGEGITFFPTP
                     PLMHGTSTLTAFIGFNFGQRVVLHRKFVPHEVLRTIEKEKVTSVSLVGDAMLRPLIDAL
                     GGPLKGIDLSSLFSVSSSGAIMSETVREQFLALVPHVMLLNNFGSSESGFNGTATEDSG
                     SDKGFRLRVNGRTQVVDPATYEPVTPGEVGRIAQRGHVPLGYYNDPAKTAETFFRRGDE
                     RWVLLGDMATVDEEGIVTVLGRGSQCIN"
     CDS_motif       complement(1661..1708)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMK26_RS20465_0002"
                     /evalue="9.20E-05"
                     /label="NRPS-A_a6"
                     /locus_tag="AMK26_RS20465"
                     /protein_end="401"
                     /protein_start="385"
                     /score="14.9"
                     /tool="antismash"
                     /translation="VPLGYYNDPAKTAETF"
     CDS_motif       complement(2303..2353)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMK26_RS20465_0001"
                     /evalue="2.40E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="AMK26_RS20465"
                     /protein_end="187"
                     /protein_start="170"
                     /score="20.1"
                     /tool="antismash"
                     /translation="FIIYTGGTTGMPKGVMW"
     misc_feature    complement(2944..2958)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.63"
                     /tool="antismash"
     misc_feature    complement(2946..2962)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.71"
                     /tool="antismash"
     misc_feature    complement(2948..2963)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.75"
                     /tool="antismash"
     misc_feature    2990..3004
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.21"
                     /tool="antismash"
     gene            3018..3818
                     /locus_tag="AMK26_RS20470"
                     /old_locus_tag="AMK26_20195"
     CDS             3018..3818
                     /NRPS_PKS="Domain: ECH (9-258). E-value: 1.5e-52. Score:
                     170.3. Matches aSDomain:
                     nrpspksdomains_AMK26_RS20470_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019069072.1"
                     /locus_tag="AMK26_RS20470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_20195"
                     /product="crotonase/enoyl-CoA hydratase family protein"
                     /protein_id="WP_073756116.1"
                     /transl_table=11
                     /translation="MSGTEHLTVRREGATLVFTLNRPEAKNALSLPMLVGLYDGWLEAD
                     ADDAIRSIVLTGAGGAFCAGMDLKALAGDGMAGQEYRERLKDDPDLHWKAMLRHHRPRK
                     PVIAAVEGPCVAGGTEILQGTDIRVAAESSTFGLFEVRRGLFPIGGSTVRLPRQIPRTH
                     ALEMLLTGRPYSAAEAARIGLVGHVVPDGTALDKALAIAEQVNACGPLAVEAVKASVYE
                     TAELTETDGLTAELKRGWPIFDTADAKEGARAFTEKRAPVYRRA"
     aSDomain        3045..3791
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMK26_RS20470_ECH.1"
                     /evalue="1.50E-52"
                     /label="AMK26_RS20470_ECH.1"
                     /locus_tag="AMK26_RS20470"
                     /protein_end="258"
                     /protein_start="9"
                     /score="170.3"
                     /tool="antismash"
                     /translation="RREGATLVFTLNRPEAKNALSLPMLVGLYDGWLEADADDAIRSIV
                     LTGAGGAFCAGMDLKALAGDGMAGQEYRERLKDDPDLHWKAMLRHHRPRKPVIAAVEGP
                     CVAGGTEILQGTDIRVAAESSTFGLFEVRRGLFPIGGSTVRLPRQIPRTHALEMLLTGR
                     PYSAAEAARIGLVGHVVPDGTALDKALAIAEQVNACGPLAVEAVKASVYETAELTETDG
                     LTAELKRGWPIFDTADAKEGARAFTEK"
     gene            4014..5000
                     /locus_tag="AMK26_RS20475"
                     /old_locus_tag="AMK26_20200"
     CDS             4014..5000
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058750.1"
                     /locus_tag="AMK26_RS20475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_20200"
                     /product="OB-fold nucleic acid binding domain-containing
                     protein"
                     /protein_id="WP_073756117.1"
                     /transl_table=11
                     /translation="MTAAPTPETLRAPLVVEFPFTRSLGPVQSAFLTGLRERTLLGVRT
                     TDGRVLVPPVEYDPVTAEEIRDLVEVAPSGTVTTWAWNPAPRRGQPLGHPFAWVLVRLD
                     GADTALLHALDAPGGPDTVRTGMRVRVRWAPHRTGAITDIACFEPYDGAPHDDGVHAGT
                     PQPRPHTGRFTDPVTGIVASARLDYTYSPGRAQTGYLHALADRRAVGERCPSCRKVYVP
                     PRGACPTCGVATTEQVEVGPRGTVTTYCIVNIKAKNLDIEVPYVYAHIALDGADLALHG
                     RIGGIPYDQVRMGLRVEPVWTEGSRYPDHYRPTGEPDADYDTYKELL"
     gene            4997..6076
                     /locus_tag="AMK26_RS20480"
                     /old_locus_tag="AMK26_20205"
     CDS             4997..6076
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003987992.1"
                     /locus_tag="AMK26_RS20480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_20205"
                     /product="thiolase domain-containing protein"
                     /protein_id="WP_073756118.1"
                     /transl_table=11
                     /translation="MTPPARDPARDIAIVAFAQTAHRRRTDDLSEVEMLMPVLHQVLAD
                     TGLKTGDIGFTCSGSSDYLAGRAFSFTMALDGVGAWPPISESHVEMDGAWALYEAWVKL
                     LTGEADTALVYAYGKSSPGPLRDVLTRQLDPYYLAPLWPDSVSLAALQAQALIDAGETD
                     EPRLATLAARNRAAAAAHNPHAQLKGPRPQGDYLVRPLRTGDCPPIGDGAAAVVLAAGD
                     RARELCDRPAWIRGIDHRIEPHGLGVRDLTDSPSTRLAAERAGAFDGPVDTAELHAPFT
                     SQEVILRKALRLDDTVDVNPSGGPLAANPVMAAGLIRLGEAAARIHRGTSDRALAHATS
                     GPCLQQNLVAVLEGEPRAA"
     gene            6066..7235
                     /locus_tag="AMK26_RS20485"
                     /old_locus_tag="AMK26_20210"
     CDS             6066..7235
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005321394.1"
                     /locus_tag="AMK26_RS20485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_20210"
                     /product="thiolase domain-containing protein"
                     /protein_id="WP_073756119.1"
                     /transl_table=11
                     /translation="MPHKEPVAVVGVGQTKHVAARRDVSLAGLVREAAHRALLDAELTW
                     ADIDAVVIGKAPDFFEGVMMPELYLADALGAVGKPMLRVHTAGSVGGSTALVAASLVAA
                     RVHSTVLTLAFEKQSESNAMWGLSLPVPFQQPLLAGAGGFFAPHVRAYMRRTGAPDTIG
                     SLVAYKDRRNALKNPYAHLHEHDITLEKVQASPMLWDPIRYSETCPSSDGACALVLTDR
                     AGAARSPRPPAWVHGGAMRSEPTMFAGKDFVSPQAGKDCAADVYRQAQIADPRREIDAV
                     EMYVPFSWYEPMWLENLGFAAEGEGWKLTESGATELEGDLPVNPSGGVLSTNPIGASGM
                     IRFAEAALQVRGQAGEHQVPGARRALGHAYGGGAQFFSMWLVGAQPPAS"
     gene            7338..7580
                     /locus_tag="AMK26_RS20490"
                     /old_locus_tag="AMK26_20215"
     CDS             7338..7580
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003987990.1"
                     /locus_tag="AMK26_RS20490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_20215"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_073756120.1"
                     /transl_table=11
                     /translation="MAETITTQQQLTGWEKPDLDLSNADWQSGSQGAGDVQIAFVEGFI
                     AMRNGGRPESPSLIFTPAEWRAFVLNAREGEFDLT"
     gene            complement(7573..8145)
                     /locus_tag="AMK26_RS20495"
                     /old_locus_tag="AMK26_20220"
     CDS             complement(7573..8145)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK26_RS20495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AMK26_20220"
                     /product="hypothetical protein"
                     /protein_id="WP_073756121.1"
                     /transl_table=11
                     /translation="MTNERVLAVCRANWEYRGIDDASVREMLAELSAHLEDAAAAGRGP
                     KAVVGDDVKAFAASWARALQPLRRRAARIAAIVPFVVGALMLVSHLLWRTTTLPVTVGR
                     LALIGAVAAVTVTVELRRGSLGMARSWLVAAVVGLPVALAADVLAGDEPLFPMPLWVTV
                     LLILPGLALTVTDTRARQQADREVTLR"
     gene            8511..8912
                     /locus_tag="AMK26_RS20500"
                     /old_locus_tag="AMK26_20225"
     CDS             8511..8912
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014146368.1"
                     /locus_tag="AMK26_RS20500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_20225"
                     /product="ACT domain-containing protein"
                     /protein_id="WP_073756313.1"
                     /transl_table=11
                     /translation="MSGERDLTRLLAGMRPELNPGHFVFATVDGPAVPPGLHPVVTVTE
                     SEGLTLVVPQDEADAASLPYDYVAGWITLRVHSALDAVGLTAAVARELADAGLSCNVVA
                     GFHHDHLFVEYARAGEALTALRRLAERSA"
     gene            9048..9548
                     /locus_tag="AMK26_RS20505"
                     /old_locus_tag="AMK26_20230"
     CDS             9048..9548
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018550733.1"
                     /locus_tag="AMK26_RS20505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_20230"
                     /product="hypothetical protein"
                     /protein_id="WP_064070633.1"
                     /transl_table=11
                     /translation="MSFLRRRSAATPAGPDFDVLAMDPGDWPGNLGAGLLPAPDGTCQG
                     VFLRYDLFGGRGPAMIIGNLPEGSPARELAEGQIPFEVAQLLAALENDEPVEVVETEDV
                     PVMQGDNLLIVRRLKLSESRISCVQFDRSDNVLVTIASWDRPITDDLYALLKPLPAELF
                     QQG"
     gene            9584..9973
                     /locus_tag="AMK26_RS20510"
                     /old_locus_tag="AMK26_20235"
     CDS             9584..9973
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008405216.1"
                     /locus_tag="AMK26_RS20510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_20235"
                     /product="RNA-binding S4 domain-containing protein"
                     /protein_id="WP_073756122.1"
                     /transl_table=11
                     /translation="MAAHEGNPTARVDSWIWAVRLTKTRSQAATACRAGHVRVNGERAK
                     PAQPVKPGDEVRLFHAGRERIVEVKQALTKRVGAPVAAEAYVDNSPPPPPREHVALAGV
                     RDRGTGRPTKRERRELDQLRGIRPS"
     gene            complement(10001..12337)
                     /locus_tag="AMK26_RS20515"
                     /old_locus_tag="AMK26_20240"
     CDS             complement(10001..12337)
                     /EC_number="4.2.3.-"
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0046246 - terpene biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018383771.1"
                     /locus_tag="AMK26_RS20515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_20240"
                     /product="terpene synthase family protein"
                     /protein_id="WP_241837979.1"
                     /sec_met_domain="T1TS (E-value: 3.2e-84, bitscore: 279.4,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQPFVLPDFYMPYPARLNPHVEAARSHTRQWARRMGMLEGSGIW
                     EEHDLDSHDYALLCAYTHPDCDADALSLVTDWYVWVFFFDDHFLEVFKRTQDLVGGKAY
                     LDRMPAFMPLDLAQDMPEPVNPVEAGLADLWARTVPSMSTGWRSRFAEATEHLLNESLW
                     ELANINEGRIANPVEYIEMRRKVGGAPWSAGLVEYAAGAEVPESVADSRPLRVLRDAFA
                     DAVHLRNDLFSYQREVEDEGENSNGVLVLEKFLGCTTQEAAEAVNDLLTSRWQQFENTA
                     LTEVPGLCLEKGLGPEECAAIAAYTKGLQDWQSGGHEWHMRSSRYMNEGALGGPSMFSG
                     VLGTSALDITTLFGRPAAARARSLSHVPHQRVGPSLLPEFDLPYPLSLSPHHEDARAKS
                     IAWADRMGLLDDIWDEPMLAGFDFALCSAGLDPDATVEELELSAEWLTWGTYGDDYYPL
                     VFGRPRDLDGAKLCTERLKTCMPVDAPEAGAAVAKSPMERALADLWGRTAGPMGQEARA
                     SLRRAMDDMLDSWLWELHNQAQHRVPDPVDYIEMRRLTFGSDLTMSLSRLRHQHALPPE
                     VLRSGTMRSLENSVSDYATMVNDLFSYQKEIEVEGEVHNGVLVVQSFFNCDYRTGVSII
                     DDLMRSRLRQFEHVKEHELPVLSERFELGRDGRAALAAYVRELEDWLAGILNWHLSVRR
                     YRDEDVRSGAGTARLRTEGLGGLAGRAVPGSDVPGGSRMPEPGLAGAGLAGAGVAGNGL
                     ASAGLPTGPTGLGTSAARLAGLFTS"
     misc_feature    12321..12336
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.81"
                     /tool="antismash"
     gene            complement(12571..14328)
                     /locus_tag="AMK26_RS20520"
                     /old_locus_tag="AMK26_20245"
     CDS             complement(12571..14328)
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020610376.1"
                     /locus_tag="AMK26_RS20520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_20245"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_073756123.1"
                     /transl_table=11
                     /translation="MIRSHTADVASLKAFIEREITTLRAEVRRRAETAGVAEPSAGRAP
                     GEAAAPSPEAGGRGGEAQCPCGQGHGAPHTCVDAGEGHDPRTCLCAALPAIPVSAALLT
                     PVRDDSGGITDFVIRAGNHIRSAEWLVSPDQQVGQRFFAEARPGAAAGGLLAALQEVMA
                     TGRALNGLVVDYTEERYGTLRRVQLVHYASSCGDRVLTTWRPVRSQAELLTIDAQHLAS
                     MGWGRWDLLSGSVTWSEGLQRIFRTDPALPWSLLELCDALVPADVGPFGEFIASVLAGE
                     EPAWTRIRFLVLGEIRTVDLLGRPVAGTDGRPWALQIVARDLTPQMRSRRRLVEKQVET
                     EQLRQQAAAERHVASALREALLPTYSEGLAELGLTVAAAYLPAEPDAAVGGDWYKCRPL
                     ADGRALIAIGDASGHGLEAVARMAQQRHATAGLAQTGACAGDVTTWLNELVCSDPTSAT
                     ATMAVGHIGADRVFRWTCAGHPAPLLLREGRAYALPTEHRGPLLGVLPGHAYETAEFPL
                     ERGDVLLFYTDGVVERRGQDITEGINALTGLLAASSGLPPRRIVDRLTEEYERGVHDDD
                     ACLLAVRVD"
     gene            complement(14440..14724)
                     /locus_tag="AMK26_RS20525"
                     /old_locus_tag="AMK26_20250"
     CDS             complement(14440..14724)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014158114.1"
                     /locus_tag="AMK26_RS20525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_20250"
                     /product="GlsB/YeaQ/YmgE family stress response membrane
                     protein"
                     /protein_id="WP_073756124.1"
                     /transl_table=11
                     /translation="MGIIAWIIIGLLAGAIAKALMPGRDPGGILVTMLIGIVGGLLGGW
                     LGKVIFGVESIDGFFDLSTWIAAIVGSVIVLALYRVFTGRGHRGHGVHA"
     misc_feature    14713..14728
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.01"
                     /tool="antismash"
     gene            14958..15341
                     /locus_tag="AMK26_RS20530"
                     /old_locus_tag="AMK26_20255"
     CDS             14958..15341
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK26_RS20530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AMK26_20255"
                     /product="hypothetical protein"
                     /protein_id="WP_073756125.1"
                     /transl_table=11
                     /translation="MKWMARTKARLLRATDRFCPSRVLPPQHPDSLHVRSPAEGTRWTC
                     VERHRISWQYTGALWHPCDVVLERRTDEGWAPAALLAAHVDPRALGTSVVVPDLPSGPY
                     RVLITSPELPAAACSPPLVISHP"
     gene            15388..15708
                     /locus_tag="AMK26_RS20535"
                     /old_locus_tag="AMK26_20260"
     CDS             15388..15708
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010986055.1"
                     /locus_tag="AMK26_RS20535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_20260"
                     /product="ANTAR domain-containing protein"
                     /protein_id="WP_073756126.1"
                     /transl_table=11
                     /translation="MKQNELNRLTTEVTQLRQALDSRAVIDQAQGMVMALTPCPAEQAW
                     QALVETSQHGNTKLRDVAAALVATAHGRPLPPRLRAPFTRALHRARADVPGPAACSRPH
                     TG"
     gene            complement(15831..16949)
                     /locus_tag="AMK26_RS20540"
                     /old_locus_tag="AMK26_20265"
     CDS             complement(15831..16949)
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060711.1"
                     /locus_tag="AMK26_RS20540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_20265"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_073756127.1"
                     /sec_met_domain="APH (E-value: 7.4e-16, bitscore: 54.4,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYTASSSVSAPPRPQRTVPAGSGPYLDPTQAGRARRWAGTVAGPL
                     SGRIDLSGTQGAQLRKVIASVHRICPEFNPVQVMRRSGRSVLLVGTTGRATAVAKCLLD
                     HSPAWVERFRHEIAAYRAFVRHRPPVRVPRLIAADPDNCTLVIERMPGRAAALTRHPLD
                     APPRADLRAALGAIKRLNDWRPPAGTFDAPLDYGSRISRYHELGLFTDRDRDDLQKLLH
                     GLAHAGGRQGMGQFCHGDALLSNILLSPAGPVLVDWEHAGWYLPGYDLATLWAVLGDAS
                     AARRHISQLAQREGPAARDAFLVNLMLVLTREIRTYETAVQRTIREAPPVGSVPVAPGA
                     VSTGEEQRLLLRRLHDDCALARRAVRAAVGTR"
     misc_feature    complement(16644..16646)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            17184..18677
                     /locus_tag="AMK26_RS20545"
                     /old_locus_tag="AMK26_20270"
     CDS             17184..18677
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017948353.1"
                     /locus_tag="AMK26_RS20545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_20270"
                     /product="hypothetical protein"
                     /protein_id="WP_073756128.1"
                     /transl_table=11
                     /translation="MTGEPNTRLADLFGLAGWSKGELARLVNRQAAAMGHPQLATDTSR
                     VRRWIDMGETPRDPVPRVLAALFTERLGRVVTIEDLGFVRHGRAGKRRDVRNTDNPDGL
                     PWAPERTAAVLTEFTGMDLMLNRRGLVGAGAALAAGSALTSAMHDWLHTDPALAADAPR
                     LDDPLHADPAGFDRYEAAPIGSQEIEALERSVEVFRAWDAARGGGLQRKAVVGQLNEVG
                     GMLAYRHPDHLQRRLWGVAANLAVLAGWMSHDVGLEPTAQKYFVIAAHAAREGGDRPRA
                     GEALSRAARQMVHLGRPDEALDLMKLARSGSGEEILPRTQAMLHTIEAWAQASMGRGQA
                     MRRTLGEAEELFVSDKADVPLPSWMQTFRSEDLYGMQALAYRTLAEHEPAAARQAQYFA
                     QKALALRNDGRQRSKIFDYLSMASACFIADDPEQADRYARLALMSMGETSSQRTWDRLR
                     EMYRLTGQYAGYSKIEDLREEIQLAMPKSTAKRSRRGQV"
     misc_feature    17226..17241
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.26"
                     /tool="antismash"
     gene            complement(18914..20383)
                     /locus_tag="AMK26_RS20550"
                     /old_locus_tag="AMK26_20275"
     CDS             complement(18914..20383)
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003959296.1"
                     /locus_tag="AMK26_RS20550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_20275"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_073756129.1"
                     /transl_table=11
                     /translation="MPSHLFADRPAPQPPERGTLDALISQTRRLRGDVDAVRRDAVADE
                     DDPQGRWQRALCDLAVHQLDDLGAQLGQLKEGVPMPLGEPAEQLEPTDPYGSMGTDEVA
                     ADPPPTGSLLSRVGSAEWNLLTDEVSWSDELYVIFGRSPDAGPMTLDELPSMVFAEDQS
                     LLTAMVTGCLIDGKPIDGEFRIVRTDGRVRTLHMMGEPVLDVDGCTASMWAVLRDVSEL
                     RRSERAVRETRDSLQRRRHIERTEHRMAVELQEAVLPPWRGSSGFPHGGPAGLDLAGQY
                     LPSGSSATIGGDWYDALELPDGDALLTVGDLTGHGVSATSTMAMLLGALRGMAVAGIRP
                     GALMGHLNQVLDSSSQPALGSAVCCRYDPRTRTLAWAQAGHPAPLLFRGGTGHALTRPE
                     GALLGATAGAAYEQAEVRLLPGDLLVLHTDGLTRGPGDTSRMDTLLELAPRFARARDAQ
                     ECVRTVVEEFGRSPREGDACVMVARIGSGRP"
     misc_feature    complement(19736..19738)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(20547..21341)
                     /locus_tag="AMK26_RS20555"
                     /old_locus_tag="AMK26_20280"
     CDS             complement(20547..21341)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (8-123). E-value: 1.2e-08. Score:
                     27.0. Matches aSDomain:
                     nrpspksdomains_AMK26_RS20555_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004979307.1"
                     /locus_tag="AMK26_RS20555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_20280"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_073756130.1"
                     /transl_table=11
                     /translation="MQVNLTGRTALVTGSTQGIGAAITTALARSGATVAVNGRTSDSVT
                     AAVKRLRAEVPDAEVVPVAADIATEEGAELAVELLPEVDVLVNNLGIFEPRPALEITDE
                     EWRRYFEVNVLAAVRLTRAYLPGMTGRGWGRVQYIASDSAVVIPAEMIHYGMSKTALLA
                     VSRGFAKEAAGTGVTVNAVIAGPTHTGGVEDLVYELVDRDLAWDEAQRVFMRKHRPQSL
                     LQRLIEPEEIAHMVVYLSSPQASATTGGAVRVDGGYVDSILP"
     aSDomain        complement(20973..21317)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMK26_RS20555_PKS_KR.1"
                     /evalue="1.20E-08"
                     /label="AMK26_RS20555_PKS_KR.1"
                     /locus_tag="AMK26_RS20555"
                     /protein_end="123"
                     /protein_start="8"
                     /score="27.0"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="TALVTGSTQGIGAAITTALARSGATVAVNGRTSDSVTAAVKRLRA
                     EVPDAEVVPVAADIATEEGAELAVELLPEVDVLVNNLGIFEPRPALEITDEEWRRYFEV
                     NVLAAVRLTRA"
     CDS_motif       complement(21225..21311)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMK26_RS20555_0001"
                     /evalue="4.00E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="AMK26_RS20555"
                     /protein_end="39"
                     /protein_start="10"
                     /score="13.1"
                     /tool="antismash"
                     /translation="LVTGSTQGIGAAITTALARSGATVAVNGR"
ORIGIN
        1 cgtcgaggcg ctgcgcgacc acctcggcct ggaccggatc gacctcctcg gccactcggc
       61 ctccggcacc ctcgccgtgc tgtacgcggc cgcgcacccc gagcggatcg ccacgctcac
      121 cgtcgtcacc ggcggcacgc gcgccgtcgg catccgggcg agcgagcagg actggcgcga
      181 ggcgaccgcc ctgcgggccg gggagccctg gtacgaggcg ggacgggccg ccttcgagga
      241 ggtgtgggcg ggccgggacg tggcggaggt ggccgagctg atcacgccgt tcgtgtacgg
      301 acgctgggac gcgaaggccc gggcgcacgc cgcgaccgcc gacgagcaga tcaactgggc
      361 ggcgtccgcc gcgtacttcg cggacggcgc cctgcccgac ccggcggcga cccgtgccgc
      421 gctcgccgcc gtcaccgcgc cggtgctcgt gtacgcgggc gagtacgacg gcggcccgac
      481 gcccgcccgc gccgcggagc tcgccgcgct gttcccgcac ggcgaggtgg ccgtgcagcg
      541 ccgcgcgggc cactacccgt gggtggacga cccgggcacc ttctcccgta ccgtcgccgc
      601 gttcctcgac cccgccgtac ggtcccgtat cgcgtaccgc gcctagggcg aggtgagccc
      661 gccgcccagg cccgccgagt tcctcgcggt ccttcgcgac gacgggttct gaaccgcgat
      721 caccagctcc ggccggtccc acatcaccgc cggcgggttg gcgttcaccg tgccgacccg
      781 ccgcgccccc acgctgcggt agaagccctc ggcgggcggg tgggagacga cccgtacggc
      841 cgtcaccccg gccgcccgcg cccgctccga catatgggcg acgagcgtac ggccgacacc
      901 gagtccctgg gcggtgtcgg cgacgaacat gaggtccagt tccggcgggg acaggacgag
      961 cgcgtagaaa ccgagcaccc ggccgtcgtc gccggcggcg acatggacct catgggcgtc
     1021 gatgtagtcg ggccccaccc ggtagcccgc caccatcggc gcgtaggggc cttcgtaggc
     1081 gcgcgaattg cgcaccagag cggtcagccg cttcgcgtcc cccgccgtcg cccgcctgat
     1141 ccgcaccggc cacgtgcccg gtcggcccgc ggtgccgcgc cctgtcatat gcgaactcat
     1201 acagagagta ttacccgtcg gcccatcccc cggagaaacg agctggtcag cgcggttcgg
     1261 cgtccgccgc cgccaccgac cgcgcccagc ggtagtccgc cttgccgctg ggcgaacgct
     1321 ggatccggtc ggtgatcacc agccgacggg gcaccttgta cccggccagc cgggtgcggc
     1381 agtggccctg gatgtcgtcc agcgagggcc gcgccgcgcc cgcgcgcagc tgcaccacgg
     1441 cggccacatg gtggccccac cggggatcgg gcacgccggc gaccagcgcg tcgtacacat
     1501 ccggatggga cttgagcgcc tgctcgacct cctcggggta gaccttctcg ccgcccgtgt
     1561 tgatgcactg cgagccgcgc ccgaggacgg tcacgatccc ctcctcgtcg accgtcgcca
     1621 tgtcgccgag cagtacccac cgctcgtcac cgcgccggaa gaaggtctcg gcggtcttgg
     1681 cggggtcgtt gtagtacccg agcgggacgt ggccgcgctg ggcgatgcgc ccgacctcgc
     1741 ccggcgtcac cggttcgtac gtcgccgggt cgaccacctg cgtacggccg ttgacccgca
     1801 gcctgaaccc cttgtcgctg cccgagtcct ccgtcgccgt gccgttgaaa cccgactcgg
     1861 aggaaccgaa gttgttcagc agcatcacat gcgggaccag tgccaggaac tgctcgcgca
     1921 ccgtctccga catgatcgcg cccgacgacg acacgctgaa cagcgacgac aggtcgatcc
     1981 ccttcagcgg gccgcccaga gcgtcgatca acggccggag catcgcgtcc ccgaccagcg
     2041 acacgctggt gaccttctcc ttctcgatcg tccgcagcac ctcgtgcggc acgaacttgc
     2101 ggtgcaggac cacacgctgg ccgaagttga agccgatgaa cgcggtgagc gtcgacgtgc
     2161 cgtgcatcag tgggggagtg gggaagaaag tgatcccctc gccgcccgcc gccacccgct
     2221 cggccagctc ctcgggggac ttcaccggct ccccggtcgg cgcaccaccg ccgagcccgg
     2281 agaagaacag gtcctcctgg cgccacatca cccccttggg cataccggtc gtgccgcccg
     2341 tgtagatgat gaacaggtcg tcccccgagc gcggaccgaa cccccgctcc ggggagccgt
     2401 ccgcctccgc gtccgtgaac gcgagccctg gcccgccctc agccgccgcc cccacccgca
     2461 ccagatgccg aagcctctcc gtcttcggca gcgcggccgc gacccgcccg gtgaactccg
     2521 cgtcgaagac gagccccgcc aggtccgcgt cccggtagag gtagaccagc tcctcctcca
     2581 cgtaccggta attgacgttc accggcacga gccgcgcctt gagacagccg agcaccgtct
     2641 gcaggtactc aacgccgttg tacaggtgca gccccacgtg ctcaccgggc cgcagcccgg
     2701 cgcccagcag atggtggccg acccggttgg cggcggcgtc gagctcggcg tacgtcagcc
     2761 gccgctccgc ccccgtaccg gggtggtcga cgtacaccag cgcctctcgg tccgggacca
     2821 cgtccaccac cgactcgaac aggtcggcaa gattgaactc caccgctcct cctccactgg
     2881 ctcggcggtc attagagcgc cgccgcgcac aagtgggaag ggtccccgca gaagaaactg
     2941 actgactgtc agaaaactat tgaactggca cccccactcc tgcaacctgt tctggatctg
     3001 gaaacgggag gactgccatg agcggtacgg aacacctcac cgtgcggcgc gagggcgcca
     3061 cactggtatt caccctgaac aggcccgagg cgaagaacgc gctgtccctg cccatgctgg
     3121 tagggctgta cgacggctgg ctcgaggccg acgcggacga cgccatccgc tccatcgtgc
     3181 tcaccggagc cggtggcgca ttctgcgcgg gcatggacct caaggccctc gccggggacg
     3241 gaatggccgg ccaggagtac cgggagcggc tgaaggacga ccccgacctg cactggaagg
     3301 cgatgctgcg ccaccaccgc ccccgcaagc cggtcatcgc cgccgtcgaa ggtccttgcg
     3361 tggccggcgg cacggagatc ctccagggca ccgacatccg ggtcgccgcc gaatcctcca
     3421 ccttcgggct cttcgaggtc cgccgcggcc tcttcccgat cggcggctcc acggtccgcc
     3481 tgccgcgcca gatcccgcgc acccacgccc tggagatgct cctgacgggc cgcccctaca
     3541 gcgcggcgga agcggcccgt atcggcctgg tcggacacgt cgtccccgac ggcaccgccc
     3601 tcgacaaggc cctggccatc gccgaacagg tcaacgcctg cggcccgctc gccgtcgagg
     3661 cggtcaaggc atccgtgtac gagacggccg aactcaccga aaccgacggc ctgaccgccg
     3721 aactcaagcg cggctggcca atcttcgaca ccgccgacgc caaggaaggc gcccgcgcct
     3781 tcaccgagaa acgcgccccc gtctaccgcc gtgcctgagc acccaaggcc accggcctcg
     3841 tgagggtgcc ccctctgggg agagacgacc ccggaggggc cacgccccca cccaccggca
     3901 ggaaccgccc cgcacgaacg gcagcggctc cggctccacc ggccggagcc acccacccgc
     3961 gccccagcga tccgcgcccc gccgcgccca gcgcggagat cggagcaccg cccatgacag
     4021 ccgcccccac gcccgagacg ctccgcgccc cgctggtcgt ggagttcccc ttcacccgct
     4081 ccctcggccc cgtccagtcc gccttcctca ccggcctgcg cgaacgcacc ctcctcggcg
     4141 tacggaccac cgacggcagg gtcctcgtcc cgcccgtcga gtacgacccg gtcaccgccg
     4201 aggagatacg cgacctcgtc gaggtcgccc ccagcggcac cgtcaccacc tgggcctgga
     4261 acccggcgcc ccggcgcggc cagcccctgg gccacccctt cgcctgggtt ctggtccggc
     4321 tcgacggcgc ggacaccgcc ctcctgcacg ccctggacgc acccggcggc cccgacaccg
     4381 tacgcaccgg aatgcgcgtc cgcgtccgct gggcaccgca ccgaacgggc gccatcaccg
     4441 acatcgcctg cttcgaaccg tacgacggcg caccgcacga cgacggcgtc cacgccggca
     4501 ccccccaacc tcgcccccac accggccggt tcaccgatcc ggtcaccggc atcgtcgcct
     4561 ccgcccgcct cgactacacc tactcgcccg gccgcgccca gaccggctac ctccacgccc
     4621 tcgccgaccg ccgcgccgtc ggagagcggt gcccctcctg ccgcaaggtg tacgtcccgc
     4681 cccgcggcgc ctgtccgacg tgcggcgtcg ccaccaccga gcaggtagag gtcggcccgc
     4741 gcggcacggt caccacgtac tgcatcgtca acatcaaggc caagaacctc gacatcgagg
     4801 tgccgtacgt ctacgcccac atcgccctcg acggcgccga cctcgccctg cacggccgta
     4861 tcggcggcat cccgtacgac caggtgcgca tgggcctgcg ggtcgagccg gtctggaccg
     4921 agggcagccg ctaccccgac cactaccgcc ccaccggcga accggacgcc gactacgaca
     4981 cctacaagga gctcctgtga cgccaccggc cagggatccc gccagggaca tcgcgatcgt
     5041 cgccttcgcc cagaccgcgc accgccgccg caccgacgac ctctccgagg tcgagatgct
     5101 catgccggtc ctccatcagg tgctggccga caccggcctg aagaccggcg acatcggctt
     5161 cacctgctcc ggttcctccg actatctcgc ggggcgtgcc ttctccttca ccatggccct
     5221 ggacggcgtc ggtgcctggc cacccatttc cgagtcgcat gtggagatgg acggagcctg
     5281 ggcgctgtac gaggcgtggg tgaagctgct gaccggcgag gccgacaccg ccctcgtcta
     5341 cgcgtacggc aagtcgtccc ccggccccct cagggatgtg ctcacccgcc agctcgaccc
     5401 ctactacctc gcccccctct ggccggactc cgtctccctc gccgccctgc aggcgcaggc
     5461 gctgatcgac gccggcgaga ccgacgaacc gcggctcgcc accctcgccg cccgcaaccg
     5521 cgccgcggcc gccgcccaca acccgcacgc ccagctcaag ggcccccgcc cgcagggcga
     5581 ctacctggtc cgcccgctgc gcaccggcga ctgcccgccc atcggcgacg gtgccgccgc
     5641 cgtcgtcctc gccgccgggg acagggcgcg cgagctgtgc gaccggcccg cctggatccg
     5701 cggcatcgac caccgcatcg aaccgcacgg cctcggcgtg cgggacctca ccgactcgcc
     5761 ctccacccgc ctcgccgccg agcgcgccgg tgccttcgac gggcccgtcg acaccgccga
     5821 gctgcacgcc ccgttcacct cccaggaggt gatcctgcgc aaggcgctcc ggctcgacga
     5881 cacggtggac gtcaacccct ccggtggccc ccttgccgcc aaccccgtca tggcggcggg
     5941 cctcatccgg ctcggggagg ccgccgcccg tatccaccgg ggcacctccg accgcgccct
     6001 cgcccacgcc acgtccggcc cctgcctcca gcagaacctg gtcgccgtcc tggaaggaga
     6061 gccccgtgcc gcataaggag cccgtggccg tcgtcggcgt cggccagacc aagcacgtcg
     6121 ccgcccgccg tgacgtctcc ctcgccggac tcgtcaggga ggccgcccac cgtgccctgc
     6181 tggacgccga actgacctgg gcggacatcg acgccgtcgt catcggcaag gcccccgact
     6241 tcttcgaggg cgtgatgatg ccggagctgt atctggccga cgccctgggc gcggtcggca
     6301 agccgatgct gcgcgtccac accgccggct cggtcggcgg ctccaccgca ctcgtcgcgg
     6361 ccagcctcgt cgccgcacgg gtccactcca ccgtcctcac cctcgctttc gaaaagcagt
     6421 cggagtccaa cgccatgtgg ggcctgtcgc tgcccgttcc gttccagcag ccgctgctcg
     6481 ccggcgcggg cggcttcttc gccccgcacg tgcgcgccta catgcgccgc accggcgcac
     6541 cggacacgat cggctccctc gtcgcctaca aggaccggcg caacgcgctg aagaacccgt
     6601 acgcgcatct ccacgagcac gacatcaccc tcgagaaggt ccaggcatcc ccgatgctct
     6661 gggaccccat ccgctactcc gagacctgtc cctcctccga cggcgcttgc gccctcgtcc
     6721 tcaccgaccg ggccggcgcg gcccgatcgc cgaggccacc ggcctgggtg cacggtggtg
     6781 ccatgcgcag cgagccgacg atgttcgcgg gcaaggactt cgtctcgccg caggccggca
     6841 aggactgtgc ggccgacgtc taccggcagg cccagatcgc cgacccgcgc cgggagatcg
     6901 acgcggtgga gatgtacgtg cccttctcct ggtacgagcc gatgtggctg gagaacctgg
     6961 gtttcgccgc cgagggagag ggctggaagc tcaccgagtc gggtgcgacc gaactcgagg
     7021 gcgacctgcc ggtgaacccc tcgggtggcg tcctgtccac caaccccatc ggcgcctccg
     7081 gcatgatccg cttcgccgag gcggcgctcc aggtgcgtgg tcaggcgggg gagcaccagg
     7141 tgcccggagc ccgccgcgcg ctggggcacg cctacggcgg cggcgcccag ttcttttcca
     7201 tgtggctggt cggtgcccaa ccgccggcct cctgaacgcc gcagaaccac cgcgtgccgg
     7261 tcgcgcgccg cgccctgtcc gtgaccggcc ccgatggcta gtctgagccc ggacgacgaa
     7321 ccgggaggag caggcacgtg gcggagacca tcaccaccca gcagcagctc acaggctggg
     7381 agaagccgga cctcgacctc agcaacgcgg actggcaatc gggcagtcag ggggcgggcg
     7441 acgtccagat cgccttcgtc gaggggttca tcgcgatgcg caacggcggc cgtcccgaga
     7501 gcccgtcgct gatcttcacc cccgccgagt ggcgtgcctt cgtgctcaat gccagggagg
     7561 gggagttcga cctcacctga gggtgacttc ccggtccgcc tgctgccggg cacgcgtgtc
     7621 ggtgacggtg agtgcgagtc ccggcagtat cagcaggacc gtgacccaca gcggcatggg
     7681 gaacagcggc tcgtcgccgg ccagcacgtc ggccgccagc gcgaccggca ggccgacgac
     7741 ggccgctacc agccagctcc tggccatccc cagcgaaccg cgccgcagct ccacggtcac
     7801 cgtgaccgcc gcgacggccc cgatgagcgc gagccggccg acggtgacag gaagcgtggt
     7861 ggtccgccac agcaggtggg agaccagcat cagcgccccg accacgaacg gcactatggc
     7921 cgcgatccgc gccgccctcc ggcgcagtgg ctgcagggcc cgcgcccagg acgcggcgaa
     7981 cgccttgacg tcgtcgccga ccacggcctt cggtccgcgc cccgccgccg cggcgtcctc
     8041 caggtgcgcg gacagctcgg cgagcatctc ccgcacggag gcgtcgtcga tgccgcggta
     8101 ctcccagttg gcgcggcaga ccgccaatac ccgctcgttg gtcatggtgt cgtttccccg
     8161 gccggcgcgc taccgcatgg ccgcatggtc gctccccacc ggacctcgcc ctcacccggc
     8221 cgccgtaccc ggtgccggtg tcgcgaccgt ccgcgccctc cgtgccgccg tgcgcgccct
     8281 gtttgccttc gccgtgccgg gcgcagccgg tcccgccgac gcccggcgcc tgctgcccgt
     8341 ggacaccgcg ccgcggccgc tcaacgaggc cgcggccgcc gcccccgccc cgccgtaccc
     8401 acctgacctg gaccgacgaa gccggtcctg tggccgtccg gcgcgcccgc gtcgcccgcc
     8461 accgtgcctg acggcgcatg tccccggccc gggggcctag ggtggcgatc atgagtggag
     8521 agcgtgatct gacccggctg ctcgccggta tgcggccgga gctgaacccc gggcacttcg
     8581 tcttcgccac cgtcgacggc ccagccgtcc cgcccggcct gcaccccgtc gtcaccgtca
     8641 ccgaatcgga gggcctcacc ctggtcgtgc cgcaggacga ggcggacgcc gcctccctcc
     8701 cgtacgacta cgtggccggc tggatcaccc tccgtgtcca ctcggcgctg gacgccgtgg
     8761 ggttgaccgc cgccgtcgcc cgggagctcg ccgacgccgg tctgagctgc aatgtcgtgg
     8821 cgggcttcca ccatgaccac ctcttcgtcg agtacgccag ggcgggcgag gctctcacgg
     8881 cactgcgccg tctggcggaa cgctccgcct gaccggcacg cctggagggc gtcgcccgaa
     8941 gcggtgaatc acggacaccc ccgtgggccg tgcggcgggg ccgtgccggg ggcgggacgc
     9001 gtggggccgg gggctggttc gggggtccgg gcacgtacca tggcggcatg tccttcctcc
     9061 gccgccgcag cgccgccaca cccgcgggcc cggacttcga cgtcctggcc atggatccgg
     9121 gcgactggcc cggcaacctc ggcgccggtc tcctccccgc ccccgacggc acctgccagg
     9181 gcgtcttcct gcggtacgac ctgttcggcg gccgcggccc cgcgatgatc atcggcaacc
     9241 tccccgaggg ctccccggcg cgcgagctcg cggagggcca gatccccttc gaggtcgcgc
     9301 agctcctggc ggcgctggag aacgacgagc cggtcgaggt cgtcgagacc gaggacgtac
     9361 cggtcatgca gggcgacaac ctgctcatcg tgcgccggct caagctctcc gagagccgga
     9421 tctcctgcgt gcagttcgac cgcagcgaca acgtgctggt caccatcgcc agctgggacc
     9481 ggccgatcac cgacgacctg tacgcgctgc tcaagccgct gcccgcggag ctcttccagc
     9541 agggctgagc cgttccgccc cgggccggat taaagtcggc accatggcag cacacgaagg
     9601 gaacccgacc gcccgggtcg acagctggat atgggccgta cggctcacca agacgcgctc
     9661 gcaggccgcc accgcatgcc gggccgggca cgtacgcgtc aacggcgagc gcgccaagcc
     9721 cgcccagccc gtcaagcccg gcgacgaggt ccggctgttc cacgccggcc gcgagcgcat
     9781 cgtcgaggtg aagcaggcgc tcaccaagcg cgtcggtgcg cccgtggccg ccgaggcgta
     9841 cgtcgacaac agcccgcccc cgccgccccg cgagcacgtc gccctggcgg gcgtacgcga
     9901 ccgcggcacc ggccggccca ccaagcggga acgccgcgaa ctggaccagc tccgcggcat
     9961 ccgcccgtcc tgatccaccg ccgcggtcgc gcggcagcgg ctacgacgtg aacaaccccg
    10021 ccagccgggc cgccgaggtc cccagccccg tcggcccggt cggaagccca gcgctcgcga
    10081 ggccattgcc cgcaaccccg gcacccgcga gcccggcacc cgcgagaccc ggctccggca
    10141 tgcgcgaccc acccggcacg tccgagcccg gcaccgcccg gcccgccagg ccgcccaggc
    10201 cctcggtccg cagccgggcc gtaccggcac cagagcggac gtcctcgtcc cggtaacggc
    10261 gcacgctgag gtgccagttg aggatcccgg cgagccagtc ctccagctcc cgcacatacg
    10321 cggcgagggc ggccctgccg tcccggccga gctcgaaccg ctcgctcagc accggcagtt
    10381 catgctcctt cacatgctcg aactggcgca gccggctccg catcagatcg tcgatgatcg
    10441 acacacccgt gcggtagtcg cagttgaaga aggactgcac caccagcacc ccgttgtgca
    10501 cctcaccctc gacctcgatc tccttctgat acgagaagag gtcattgacc atcgtggcgt
    10561 agtccgacac ggagttctcc aggctccgca tcgtcccgct ccgcagcacc tccggcggca
    10621 gggcgtgctg gtgccgcagc cgcgacaggc tcatggtgag gtccgagccg aacgtcaggc
    10681 gccgcatctc gatgtagtcg accggatcgg gcacccggtg ctgggcctgg ttgtgcagct
    10741 cccacagcca gctgtccagc atgtcgtcca tcgcccggcg cagcgaggca cgcgcctctt
    10801 gccccatcgg ccccgcggtg cgcccccaca ggtcggcgag cgcgcgctcc atcgggctct
    10861 tcgccaccgc cgccccggcc tcgggggcgt cgacgggcat gcaggtcttc agccgctcgg
    10921 tgcacagctt cgccccgtcg aggtcacgcg gccgcccgaa caccagcggg tagtagtcgt
    10981 ccccgtacgt cccccaggtc agccattcgg cgctcagctc cagctcctcg acggtggcgt
    11041 ccgggtcgag gccggccgag cagagcgcga agtcgaaacc ggcaagcatc ggctcgtccc
    11101 agatgtcgtc cagcagcccc atccggtccg cccaggcgat ggacttggcg cgggcgtcct
    11161 cgtggtgcgg gctgagcgac agcgggtacg gcagatcgaa ctccggcagc agcgaggggc
    11221 cgacccgctg atgcggtacg tggctgaggc tgcgtgcccg cgcggcggcc ggccggccga
    11281 agagcgtcgt gatgtcgagc gccgacgtgc cgaggacccc gctgaacatc gacggtccgc
    11341 ccagcgcgcc ctcgttcatg tagcggctgg agcgcatgtg ccattcatga ccgcccgact
    11401 gccagtcctg aagccccttg gtgtacgcgg cgatcgcggc gcactcttcc gggcccaggc
    11461 ccttctccag gcacagcccg gggacctcgg tcagcgcggt gttctcgaac tgctgccacc
    11521 gtgaggtcag caggtcgttg accgcctcgg ccgcctcctg tgtcgtacag cccaggaact
    11581 tctccagcac caggacgccg ttgctgttct cgccctcgtc ctcgacctcg cgctggtagg
    11641 agaacaggtc gttgcgcagg tgcacggcat cggcgaacgc gtcccgcagc acccgcagcg
    11701 gccgggagtc cgccaccgac tcgggcacct cggcgcccgc cgcgtactcc accagccccg
    11761 ccgaccaggg cgcgcccccg accttgcgcc gcatctcgat gtactcgacg gggttggcga
    11821 tccgcccctc gttgatgttc gccagttccc acagggactc gttcagcaga tgctcggtcg
    11881 cttccgcgaa ccgggagcgc cagccggtcg acatgctcgg cacggtccgc gcccacaggt
    11941 cggcgagccc cgcctccacc gggttcaccg gctccggcat gtcctgggcg aggtccagcg
    12001 gcatgaaggc cggcatccgg tccagatacg ccttgccgcc caccaggtcc tgggtgcgtt
    12061 tgaagacctc caggaagtgg tcgtcgaaga agaacaccca cacgtaccag tcggtgacca
    12121 gggacagggc gtcggcgtcg cagtccgggt gggtgtacgc gcacagcagg gcgtagtcat
    12181 gggagtcgag gtcgtgttcc tcccagatcc ccgacccctc cagcatcccc atgcgccgcg
    12241 cccactgcct ggtgtgggaa cgggcggcct ccacgtgggg attgaggcgt gccggatagg
    12301 gcatgtagaa atccggcaga acgaagggct gtgccatgcg tgcgaggcct ttcggtgaag
    12361 gtggacatac cgggccaccc cctacccccc gccgacacgg tccacgccgc gagccgcatt
    12421 agtcgtatga gcggcttggt gtggtggggc cacacacgcg agacggtcac gtccgacgcc
    12481 ttctcgaagg ccatccggtg cccggatgtg cccggacgtg tcgaaggccg gcgcgaggtt
    12541 tcacatcacc aggcgcgccg gccgggcggt tcagtccacc cggaccgcga gcaggcacgc
    12601 gtcgtcgtcg tggacgccgc gctcgtactc ctcggtgagc cggtcgacga tccgtcgcgg
    12661 cggcagaccg ctgctcgccg ccagcaggcc cgtcagcgcg ttgatgccct cggtgatgtc
    12721 ctggccgcgc cgctcgacca ccccgtcggt gtagaacagc agcacgtcgc cccgctccag
    12781 cgggaactcc gccgtttcgt aggcgtgccc cggcagcaca cccagcagcg gcccccggtg
    12841 ctccgtgggc agcgcgtacg cgcgcccctc acgcagcagc agcggcgcag ggtgccccgc
    12901 acacgtccac cggaacaccc ggtccgcgcc aatgtgcccg accgccatgg tcgccgtcgc
    12961 cgaggtgggg tcgctgcaca ccagctcgtt cagccaggtg gtgacgtctc cggcgcacgc
    13021 ccccgtctgg gcgagccccg ccgtcgcatg ccgctgctgg gccatccggg cgaccgcctc
    13081 cagaccgtgc ccgctcgcgt cgccgatggc gatcagcgcc cggccgtccg ccagcggtcg
    13141 gcacttgtac cagtcgccgc ccaccgcggc gtccggctcg gcgggcagat aggccgccgc
    13201 gacggtcagg cccagctccg ccagcccttc cgagtacgtc gggagcagcg cctcccgcag
    13261 cgccgaggcg acgtgccgct ccgccgcggc ctgctgccgc agctgctccg tctccacctg
    13321 cttctccacc agccggcgcc ggctgcgcat ctggggagtg aggtcacggg ccacgatctg
    13381 cagcgcccat ggccggccgt ccgtgcccgc caccgggcgg cccagcaggt cgaccgtccg
    13441 gatctcgccc agcaccagga acctgatccg ggtccaggcc ggctcctcac cggccagcac
    13501 cgaggcgatg aactcgccga acggccccac atcggccggc accagcgcgt cgcacagctc
    13561 cagcagcgac cacggcagcg ccggatccgt acggaagatc cgctgaagcc cctccgacca
    13621 ggtcaccgac ccggacagaa ggtcccagcg cccccagccc atggacgcca ggtgctgcgc
    13681 gtcgatggtc aggagctccg cctggctgcg caccgggcgc catgtcgtca gcacccggtc
    13741 gccgcaggac gacgcgtaat ggaccagctg gacgcgcctg agcgtgccgt accgctcctc
    13801 ggtgtagtcc acgaccaggc cgttcaaggc gcggcccgtc gccatgacct cctggagcgc
    13861 ggccagcagc ccgccggcgg ccgcgcccgg ccgggcctcc gcgaagaacc gctggcccac
    13921 ctgctggtcg ggcgagacca gccattcggc cgaacgaatg tggttgccgg cgcggatgac
    13981 gaagtccgtg atgccaccgg agtcgtcccg caccggcgtc agcagcgccg ccgacaccgg
    14041 aatggccggc agcgccgcac acaggcacgt ccgggggtcg tgtccctcac cggcgtccac
    14101 gcacgtgtgc ggggcgccgt ggccctggcc gcacgggcac tgggcctccc caccccggcc
    14161 gccggcctcc ggcgacggcg ctgccgcctc gccgggggcc cggccggccg agggctccgc
    14221 cacgccggcc gtctccgccc tgcggcgcac ctccgcccgc agcgtcgtga tctcgcgctc
    14281 gatgaacgcc ttcagcgacg ccacatcggc ggtgtgcgac cggatcatga gggcgccacg
    14341 cccccggcgc tcaccgtcgc cccggcggcc ggagccggtc tcgtgccggt gccgggaagg
    14401 ttcatggtga cggcctttct cctcgtactc cgttcggggt caggcgtgaa ccccgtgtcc
    14461 ccggtgtccc cgcccggtga agacccggta gagggcgaga acgatcactg atccgacgat
    14521 cgcggcgatc cacgtcgaca ggtcgaagaa gccgtcgatc gactccacgc cgaagatgac
    14581 cttgcccagc cagccgccca gcagaccgcc cacgatgccg atcagcatgg tcaccaggat
    14641 gccgcccggg tcccgtcccg gcatcagcgc cttggcgatc gcaccggcga gcagcccgat
    14701 gatgatccac gcgatgattc ccattctcga cctcccatag gtttccgcac gccccgcgtc
    14761 gcggcgggac ccttcaccgc gttgccgcgc ccggggccga taaacaccgg cggccctcac
    14821 ccgcccggcg caggaccgaa cggcccggcc cgaacgggcc ggaagtcccg taacggacag
    14881 gccggtcggc gtgcttgccc ccgtcccgta ccggcaacac caacggcagc cgctcaccga
    14941 agagaagaga accacccatg aagtggatgg cccgtaccaa ggcccgactg ctgcgcgcca
    15001 ccgaccggtt ctgcccgtcg cgcgtcctgc cgccgcagca cccggactcg ctgcacgtcc
    15061 gcagccccgc cgaggggacc cgctggacct gtgtggaacg gcaccggatc agctggcagt
    15121 acaccggtgc cctgtggcac ccctgcgacg tggtgctcga acggcgcacc gacgagggct
    15181 gggccccggc cgcgctcctc gccgcgcacg tcgacccccg cgccctgggc acctccgtcg
    15241 tcgtacccga cctgccctca gggccctacc gcgtcctgat cacctcgccg gagctgcccg
    15301 ccgcggcctg cagcccgccc ctggtgatca gccacccgtg accccatccg gcccgcaccg
    15361 gcccgccgca ccaaggatcc gccgtacgtg aagcagaacg aactcaaccg gctcaccacc
    15421 gaggtgaccc aactgcgcca ggccctcgac agccgtgccg tcatcgacca ggcccagggc
    15481 atggtcatgg ccctcacgcc ctgcccggcc gaacaggcgt ggcaggccct ggtggaaacc
    15541 tcccagcacg gcaacaccaa gctgcgcgac gtcgccgccg cgctggtcgc caccgcccac
    15601 ggccgtccgc tgccgccccg gctgcgggcc ccgttcaccc gggccctcca ccgtgcccgg
    15661 gcggacgtgc ccgggccggc ggcctgcagc cgaccacata ccggctgagc cgtcgccgcg
    15721 cccgatcccc ggcccagccc ctggccgggc gggcgagcgg gcatacgaca gcgcgctgtg
    15781 ggccggtgtg tcggcaccgg tcacacagcg cgcttccccc tcgtcgccgg tcagcgtgtg
    15841 ccgaccgccg cgcgcacggc ccgccgtgcc agtgcgcagt catcgtgcag ccgccgcagc
    15901 agcagccgct gttcctcccc ggtcgacacc gcacccggcg cgaccggcac cgagccgacg
    15961 ggtggcgctt cgcgtatcgt gcgctgcacg gccgtctcgt acgtacggat ctcgcgcgtc
    16021 agtaccagca tcaggttcac caggaacgcg tcccgtgccg ccgggccctc gcgctgggcc
    16081 agctggctga tgtgacgccg ggccgcggag gcgtctccca gcaccgccca cagcgtcgcc
    16141 aggtcgtatc ccggcaggta ccacccggcg tgctcccagt cgaccagtac gggaccggcc
    16201 ggcgacagca ggatgttgga gagcagcgcg tccccgtgac agaactggcc catgccctgg
    16261 cgcccgcccg cgtgcgccag cccgtgcagc agcttctgca ggtcgtcccg gtcccggtcg
    16321 gtgaacaggc ccagctcgtg gtagcgggag atccgcgagc cgtagtccag cggggcgtcg
    16381 aacgtcccgg ccggcggccg ccagtcgttg agccgcttga tcgcgccgag cgcggcccgc
    16441 aggtccgccc ggggcggcgc gtccagcggg tgacgtgtga gggccgcggc ccggcccggc
    16501 atccgttcga tcaccagggt gcagttgtcg ggatccgccg cgatcagccg cggcacccgc
    16561 accggcggcc ggtgccgtac gaaggcccgg taggcggcga tctcgtggcg gaaccgctcg
    16621 acccacgcgg gggagtggtc cagtaaacac ttggcgacgg cggtggcgcg tccggtcgtc
    16681 ccgacgagca ggaccgagcg gccgctgcgc cgcatcacct gcaccgggtt gaactccggg
    16741 cagatccggt gcaccgacgc gatcaccttc cgcagctgcg cgccctgggt gccggacaag
    16801 tcgattctcc cgctgagcgg tccggccacc gtccccgccc agcgccgggc ccgacccgcc
    16861 tgggtgggat ccagatacgg tccgctgccg gccgggacgg tgcgctgcgg ccggggcggg
    16921 gcggacacgg aggacgatgc tgtgtacatg ggcgagacag atcccttcgt gtgccgacga
    16981 tttgcgtacg ctgccccgtc ccggcaaccg gccgacaccc tggggaatga gggccggttg
    17041 ccggggcggg gtggcgcttt cctacctgac acccgggcgc gggtggcaca ccatctggcg
    17101 gaccctggcg aaccctggcg aatagtcgcc agccctatga cagcgggtta gtgtcaactc
    17161 agccgagaac ctgggggctt gacgtgaccg gagaacccaa cacccgcctt gcagacctgt
    17221 tcggcctggc cggctggtcc aaaggggaac tcgcaagact cgtgaaccgg caggcggcgg
    17281 ccatgggcca cccccagctg gcgaccgaca cctcgcgggt ccggcgctgg atcgacatgg
    17341 gggagacccc gcgcgatccc gtaccccggg tgctggcagc cctgttcacc gagcgactcg
    17401 gccgtgtcgt gaccatcgag gacctcgggt tcgtacgaca cgggcgcgcc gggaaacggc
    17461 gggacgtcag gaacaccgac aaccctgacg ggctgccctg ggcgcccgag cgtacggctg
    17521 cggtcctcac cgaattcacg ggaatggacc tcatgctcaa ccgacgcggc ttggtgggcg
    17581 cgggcgccgc gctcgccgca ggctccgcac tcaccagcgc catgcacgac tggctccaca
    17641 ccgaccccgc tctcgctgcc gacgcccccc gcctcgacga tcccctgcac gccgaccccg
    17701 ccggtttcga ccgctacgag gccgccccca tcgggtccca ggagatcgag gcgctggagc
    17761 gctccgtcga agtgttccgc gcctgggacg ccgcccgtgg cggcgggctc cagcgcaagg
    17821 ccgtcgtcgg ccagctcaac gaggtgggcg gcatgctcgc ctaccgccac cccgaccacc
    17881 tccagcgccg gctctggggt gtcgccgcca acctggcggt cctcgccggg tggatgtccc
    17941 acgacgtggg cctggagccc accgcccaga agtacttcgt catcgccgcc cacgcggcgc
    18001 gcgagggcgg tgaccggccg cgcgccggtg aggccctctc ccgcgccgcc cgccagatgg
    18061 tccacctggg gcgccccgac gaggccctgg acctgatgaa gctcgccagg tcgggctcgg
    18121 gtgaggagat cctgccgcgt acgcaggcca tgctgcacac catcgaggcc tgggcacagg
    18181 cctccatggg ccgcggccag gcgatgcgcc gcactctggg cgaggccgag gaactgttcg
    18241 tctccgacaa ggccgacgtg cccctgccga gctggatgca gaccttcagg agcgaggacc
    18301 tgtacggcat gcaggcgctc gcctaccgga cgctggccga gcacgagccg gccgcggcca
    18361 ggcaggcgca gtacttcgcg cagaaggcgc tggcgctgcg caacgacggc cggcagcgat
    18421 cgaagatctt cgactacctc tccatggcgt cggcgtgctt catcgccgac gaccccgaac
    18481 aggccgaccg gtacgcgcgg ctcgccctga tgtcgatggg cgagacgtcc tcccagcgca
    18541 cctgggaccg gttgcgggag atgtaccggc tcactgggca gtacgcgggc tactcgaaga
    18601 tcgaggacct ccgcgaggag atccagctgg ccatgccgaa gagcacggcg aagcggtccc
    18661 ggcgcggcca ggtctgacga cgcccgggcc gttcggcgtc gcacacgccg accggccgca
    18721 ccacttccta cgatccgcgt ccggcgtcgc atgtcggccg gccgcaccac ttcctacgat
    18781 ccgcgttctg cgccgcaccc gggccggacg cacctctccc tacgatccca gccccaccca
    18841 tctcacagcc ccacccatca acgaccgcgc ccacgcatcg cgaccgtacg gaacacgacg
    18901 catgggcccg gactcagggc cggccgctgc cgatcctggc gaccatcaca cacgcgtcac
    18961 cctcacgcgg tgagcgaccg aactcctcca ccaccgtccg cacacactcc tgcgcatcgc
    19021 gcgcccgggc gaaccgcggt gccagctcca gcaaggtgtc catacgagac gtgtcacccg
    19081 gaccgcgggt cagcccgtcc gtgtgcagca ccagcaggtc cccgggcagc agccggacct
    19141 cggcctgctc gtacgccgcc ccggccgtcg cccccagcag ggctccctcc ggacgcgtca
    19201 gcgcgtgccc cgtcccgccg cggaacagca gcggggcggg gtgcccggcc tgcgcccagg
    19261 cgagcgtccg ggtccggggg tcgtagcggc agcacaccgc actgcccagg gcgggctgcg
    19321 aggaggagtc cagcacctgg ttgaggtggc ccatcagggc cccggggcgg atcccggcga
    19381 ccgccatgcc gcgcagggcg cccagcagca tcgccatcgt ggacgtcgcg gacaccccgt
    19441 gcccggtcag atcgcccacg gtcagcagcg cgtcgccgtc cggcagttcg agtgcgtcgt
    19501 accagtcgcc gccgatcgtc gcgctggacc cggacggcag gtactgcccc gccaggtcga
    19561 ggccggccgg ccccccgtga gggaagccgg aggagccgcg ccacggcggc aggaccgcct
    19621 cctgcagttc cacggccatc cggtgctcgg tccgttcgat gtgccggcgg cgctggagcg
    19681 agtcgcgtgt ctcgcgcacg gcccgctcac tgcggcgcag ttcgctgacg tcccgtaaaa
    19741 ccgcccacat cgacgcggtg cacccgtcga cgtcgaggac gggctcgccc atcatgtgca
    19801 gggtgcgcac ccggccgtcc gtacggacga tccggaactc gccgtcgatg ggcttgccgt
    19861 cgatcagaca gcccgtcacc atcgcggtca gcagcgactg gtcctcggcg aacaccatgg
    19921 agggcagctc gtccagggtc atgggcccgg cgtcggggga gcggccgaaa atgacgtaca
    19981 actcgtcgga ccagctcacc tcgtcggtaa ggagattcca ctccgcgctg ccgacccggc
    20041 tgagcagcga cccggtgggg ggcgggtccg ccgccacctc gtcggtgccc atgcttccgt
    20101 acggatccgt cggctccagc tgctccgccg gctccccgag gggcatgggg acgccttcct
    20161 tgagctggcc caactgcgca cccaggtcgt cgagctggtg gacggcgagg tcgcacagcg
    20221 ctcgctgcca gcggccctgc gggtcgtcct cgtccgccac ggcgtcccgg cgcacggcat
    20281 cgacgtctcc gcgcagccga cgggtctgcg agatcaaggc gtccagcgtg ccgcgctcgg
    20341 gcggctgtgg ggcgggacgg tccgcgaaca gatgggacgg catgtcgtac tccgatacgg
    20401 gcgcggcgcg gccagggtcg tcaaactaag gaccggttac gactgttgca caggcggaga
    20461 ctgcctgtaa ggggtttggc aacactcgat acggtggtgc tcatggcata tgtcaaaggc
    20521 ccggtgggaa caggccatcc ggtggatcac ggcaggatcg aatccacata gccgccgtcg
    20581 acccgcaccg ctccaccggt cgtcgccgac gcctgcgggg agctgaggta caccaccatg
    20641 tgcgcgatct cctccggctc gatcagccgt tgcaacaggg actgcggccg gtgcttgcgc
    20701 atgaacacgc gttgggcctc gtcccatgcc aggtcccggt ccaccagctc gtagacgagg
    20761 tcctcgacac cacccgtgtg agtgggtccg gcgatgaccg cgttgacggt gacgcccgtt
    20821 ccggcggcct ccttggcgaa accgcggctc actgccagca gcgccgtctt ggacatgccg
    20881 tagtggatca tctcggccgg gatcacgacg gccgagtcac tggcgatgta ctggacacgg
    20941 ccccagccgc ggcccgtcat gcccggcagg tacgcgcggg tcagccgcac cgccgcgagc
    21001 acgttcacct cgaagtaccg ccgccactcc tcgtccgtga tctccagggc gggccgcggc
    21061 tcgaagatgc ccaggttgtt gacgaggacg tccacctcgg gcagcagctc aacggccagc
    21121 tccgcgccct cctcggtggc gatgtccgcg gccacgggga ccacctcggc gtcggggacc
    21181 tccgcccgca gccgcttcac ggcggccgtg acactgtccg aggtgcgccc gttgaccgcc
    21241 accgtcgccc ctgagcgcgc cagggcggtg gtgatcgccg cgccgatgcc ctgtgtcgag
    21301 ccggtgacga gcgccgtcct gcccgtgaga ttcacctgca tccgcccggt ttcccttctc
    21361 gcgtgcggtc ccccgcatcc catgcatccc ttcccgctcc cccgtcgccg gaagcgccgg
    21421 aagcgccgga agcgccggaa ggggcgccgc cgtgcgcaca caccgcccgt acgacgtgga
    21481 gtgccgcaca gcgggtaccc gggccttccg gcgccgggcc cccgggccgg tgcccgatgt
    21541 cgagccgtcg gaggacagga gccgtgaata tgaacgccgg gaagcgggtc gtcgtcactg
    21601 gagccaccgg aaatgtcggc acgagtgtgg tggcggccct cgccgaagac ccgcagatcg
    21661 catccgtact gggcctggcc cgccggctgc ccggctggtc accgccgaag accgactggg
    21721 ccgaggtgga cctgcgggac gaggcgaccg acctcgtcag gcacttcgag ggcgccgacg
    21781 ccgtgatcca cctggcctgg gccttccagc ccacgcacga cgcggtggcc acctggcgca
    21841 ccaacgtcct cggcagcctc acggtgttcc gggacgtctc cgccgccggc gtgcccgtgc
    21901 tcgtccacgc ctcctcggtg ggcgcgtact cgccggggcc gaaggacggc gcggtcgacg
    21961 agtcatggcc cacgcacggc tggccggagg ccgcgtactg ccgggagaag gcctacctgg
    22021 aacgggtcct ggacgccttc gaggcccgca acccgggcat gcgggtggtg cggatgcgcc
    22081 cggcgttcct gttcaaggag gagtcgggga gcgaacagcg gcggatcttc gccggccggt
    22141 tcatgcccgg gcagctcgcc gggcccaaga cgatccccgt cgtccccgac atccccggtc
    22201 tgcgcttcca ggccctgcac accgacgacg cggcccaggc ctaccggctc gcggtcacca
    22261 aggacgtgag cggtgccttc aacctggccg ccgagccgcc cctcgacgcg cggcaactcg
    22321 ccgacctcct cgacgcc
//
