LOCUS       NZ_LIYH01000004        25057 bp    DNA     linear   CON 28-MAR-2024
DEFINITION  Streptomyces sp. CB03234 scaffold4, whole genome shotgun sequence.
ACCESSION   NZ_LIYH01000004
VERSION     NZ_LIYH01000004.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CB03234
  ORGANISM  Streptomyces sp. CB03234
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 931391)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 931391)
  AUTHORS   Yan,X., Ge,H., Hindra,F., Yang,D., Huang,T., Crnovcic,I. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-SEP-2015) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2015
            Assembly Method                   :: CLC Genomics Workbench v. 7.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905885.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:52:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,127
            CDSs (total)                      :: 7,053
            Genes (coding)                    :: 6,894
            CDSs (with protein)               :: 6,894
            Genes (RNA)                       :: 74
            rRNAs                             :: 2, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 159
            CDSs (without protein)            :: 159
            Pseudo Genes (ambiguous residues) :: 0 of 159
            Pseudo Genes (frameshifted)       :: 70 of 159
            Pseudo Genes (incomplete)         :: 112 of 159
            Pseudo Genes (internal stop)      :: 10 of 159
            Pseudo Genes (multiple problems)  :: 33 of 159
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:29:50
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 465723
            Orig. end                         :: 490780
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LIYH01000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25057
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="4"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25057
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25057
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15057](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15057
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(711..2234)
                     /locus_tag="AMK26_RS37845"
     CDS             complement(711..2234)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK26_RS37845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_241837967.1"
                     /transl_table=11
                     /translation="MTTDDPTTPARAAVPDRAKPPGPPDPATGPVTPPATTPVDAAYAD
                     AVRLGAASPAGETPVETAHPADPHAGTAQSRTVHTNGTYTNGTDANGTYRSGTDANGTY
                     PDAPRPGSGSFTAGFPGTVPPRPENPPFEAARPEAVPPAVTERATGSAPAAPTPTGRDT
                     DRNTEAEREAEADAASTDATRTADAVRAAAGPVDAALVDAVLAGSKSAGADGDDSDEPI
                     RTLLWTAATYRPLEEVAALVALLKSTGAVSSPADEALRAAAVVRPLEEVRQLVAMLNEA
                     GHPLDEADTALRAAAVGRPIEDVAELVSILGTGDAGARPAPAAASASAPGPAMKAGEGP
                     IAVPENPNVRPPRSASVTPSLEQPVTVADLARESASPALRSGLRWPAAAALFACGVIHL
                     PTDLAGLRSGGNADTLAFAVTVLCLVLGLWLGVRDTVRVWAAAGATAIGVVALHAVAGG
                     SDFDPLGGSVGAPYAWASAAAVMSAALAAALAGAAVLRRQREPDATNGT"
     misc_feature    complement(2430..2450)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.62"
                     /tool="antismash"
     misc_feature    2433..2445
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 16.34"
                     /tool="antismash"
     misc_feature    complement(2490..2507)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 22.23"
                     /tool="antismash"
     gene            2513..2701
                     /locus_tag="AMK26_RS19145"
                     /old_locus_tag="AMK26_18875"
     CDS             2513..2701
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136474.1"
                     /locus_tag="AMK26_RS19145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_18875"
                     /product="hypothetical protein"
                     /protein_id="WP_073755899.1"
                     /transl_table=11
                     /translation="MTSTEYELRDRTKILDSDIEEALNPGEAAGFYRDTRECGILALEA
                     GAGKLLLSPPTPRPKKG"
     misc_feature    complement(2879..2896)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 22.23"
                     /tool="antismash"
     gene            2902..3090
                     /locus_tag="AMK26_RS19150"
                     /old_locus_tag="AMK26_18880"
     CDS             2902..3090
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136474.1"
                     /locus_tag="AMK26_RS19150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_18880"
                     /product="hypothetical protein"
                     /protein_id="WP_073755900.1"
                     /transl_table=11
                     /translation="MTSTERELRDRTKVLDSDIEEALNPGELSGFYRNTRECAGLALQA
                     GAGKLLLSPPTPRPKKG"
     misc_feature    2932..2945
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.04"
                     /tool="antismash"
     gene            3103..3840
                     /locus_tag="AMK26_RS19155"
                     /old_locus_tag="AMK26_18885"
     CDS             3103..3840
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020700151.1"
                     /locus_tag="AMK26_RS19155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_18885"
                     /product="hypothetical protein"
                     /protein_id="WP_073755901.1"
                     /transl_table=11
                     /translation="MEQPGTSTPLMGAVQELATQVVSALTSGGHSRVSAGTAVTIGDDD
                     LGLAAVRVLGADVLLPSVLYRRPPAPVDLAVCEKAVLAYPPAPDASATSRWTHWAMTRT
                     LRDLGASAAVESPDGAEPDATWLEDLPWQALTHQLALLAALAVPAAGSTAHSTAGSMAD
                     CAVAHVAGRRVVDVARGFVRAVRRRGWQQAAGAGRWLAVLDGVPDTLGLDAGLEFVAQM
                     GGDDPRVALHLHAARHARAGAPG"
     misc_feature    complement(3120..3134)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.36"
                     /tool="antismash"
     gene            3837..4784
                     /locus_tag="AMK26_RS19160"
                     /old_locus_tag="AMK26_18890"
     CDS             3837..4784
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020116090.1"
                     /locus_tag="AMK26_RS19160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_18890"
                     /product="hypothetical protein"
                     /protein_id="WP_073755902.1"
                     /transl_table=11
                     /translation="MTATDVRRVAEAALGWLSDNRDGFRLGDDALEPDADVNSSWKPLG
                     ELAQTCVCVRRHTPPGSALHDTASDLLDHAWHQTRDGALFLDLQRLEPCATYPLEVYAA
                     FASGGLRHRAYEDFTAALLRTRSWRTTELLPNRLLSILNSERRSGFTPHEATAAVLRRT
                     WLGGLPEPWLFERTAGYTLTHVVYHLTDWGHDVDGVPADVAAYLDTWLPAWLDGCVETE
                     HWDLCCELLAVAAGLPEPLPPELTEDAWAAVARAQDDTGALTEMGRGPRGEEVLRVFAN
                     CYHSTLVAAFAATLTAARRPAGRSTDDTHRGVPA"
     gene            4781..5710
                     /locus_tag="AMK26_RS19165"
                     /old_locus_tag="AMK26_18895"
     CDS             4781..5710
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007381713.1"
                     /locus_tag="AMK26_RS19165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_18895"
                     /product="hypothetical protein"
                     /protein_id="WP_073755903.1"
                     /transl_table=11
                     /translation="MSAASTRLVHTVGVGAIEWLHEHRDGFRLEPDVDPEIGFLERFKP
                     VGELAVICKVLFREGVAGSRQADLARRLLDHAWRDVLDGGRMLVRGQRTEPTSPIPFEV
                     YVPFRELGYSQPELERAIRLNHRLTGWGALEVQPVRRLGLSAFERRFGLTASLPEDVAL
                     SRTWLGHTPEPWTVSAHTAYDITHTVFHLTDWGENPAGLPPRIASHLDLWLPVWLDDWL
                     DLERWDLLGELLVVDACLPRPTLDARAWEGFAAAQQPDGAMPALGPMPDGDPDDVFDIV
                     YHSTLVAAFASVLATSRALAQLTAEAPA"
     gene            5707..6786
                     /locus_tag="AMK26_RS19170"
                     /old_locus_tag="AMK26_18900"
     CDS             5707..6786
                     /EC_number="3.1.1.103"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016433847.1"
                     /locus_tag="AMK26_RS19170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_18900"
                     /product="serine hydrolase domain-containing protein"
                     /protein_id="WP_079277680.1"
                     /transl_table=11
                     /translation="MTADAHRAAPGDHEHHEHHQDRDDAGARLEEAVRAVDAPDVVLAL
                     SRHGRRTVRCGGTAPPPPVPRDRLRYELGSASKTYTGLLLADLIHSGTLSGTDPATALL
                     DPARPPGRHPATLTHLMTHTSGLPPLPADFYPQALPRWYTNPYAHYPAERVVRAFLRAR
                     PRHRPGSRWRYSNFAVAVLGHTLVAATATPWERLLTDCVLGPLGLVDTALRPTGPDTDA
                     TGHRLDGTTPTPPLHIGGFQAAGALRATPYDLLTFLEAHLRPERSPLAAALLEVRRPLL
                     RRGPGRRETHTLAWFHHPAEGGTMYFHIGATCGQTAFLGFRPDTGTALAGLATRRYSRK
                     DTLVPTAYALLSSSEDHPC"
     gene            6780..7580
                     /locus_tag="AMK26_RS19175"
                     /old_locus_tag="AMK26_18905"
     CDS             6780..7580
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018090688.1"
                     /locus_tag="AMK26_RS19175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_18905"
                     /product="VOC family protein"
                     /protein_id="WP_073755904.1"
                     /transl_table=11
                     /translation="MLTTDFVPGTPNWIDLGAPDTDAAVAFYSAVFGWTFQSAGPEAGG
                     YGFFQRDGGTVAALGPLTEEGASPAWTPYFHTPDADATSKAVEQAGGTVRVPPMDVFTA
                     GRMAAFTDPTGADFAVWQPGDTKGLDTVMEPNTLCWTELYTTDAAAAKDFYRSVCSWQY
                     QDMDMGGGMVYSVVSSPGGGTDDDPGQGGIMQLQEENLAAGSGSEWHPYFGVTDCDATF
                     ATATEHGATPLVAPIDAPGVGRLAMLMDPSGAPFALIKGDPTTT"
     gene            complement(7598..8580)
                     /locus_tag="AMK26_RS19180"
                     /old_locus_tag="AMK26_18910"
                     /pseudo=""
     CDS             complement(7598..8580)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018559332.1"
                     /locus_tag="AMK26_RS19180"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_18910"
                     /product="winged helix-turn-helix domain-containing
                     protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGWWQVNADTLAGSRFVVSPLAEAIACLKTLERGTAAHPGERGWL
                     DAHLPAYRERLAGDPVTALLVRAALGRTWNADFLTPTPGGEGEAVFEEEVERIRTWPPG
                     TARADLTVSLGGPLPARLHRSDLPERTAELLAWVWTRTVLPSWPRRRRVLEADVVARTA
                     RLGRAGWAGALDGMRSGMRWLGGDRSRSVRTPIRRGRSPGRG"
     gene            8651..9874
                     /locus_tag="AMK26_RS19185"
                     /old_locus_tag="AMK26_18915"
     CDS             8651..9874
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088481.1"
                     /locus_tag="AMK26_RS19185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_18915"
                     /product="MFS transporter"
                     /protein_id="WP_073755905.1"
                     /transl_table=11
                     /translation="MRTYRELFRTPEFTPLFLACAAQVAAQTVSGLALSTLVHRATGSA
                     LLSALAMFGPALAQVVGATTLLSAADRLPPRAAMTGLAVLFGLGTAVQAIPGLPVWALF
                     SVLAVLGVLGSLGGGVRYGLLNEIVAKDGYLLGRSLLNTSVGVTQICGFGVGGVLVTTV
                     SPRGTLLTGAALYVAAAAVARFGLARRPPRAAGRASVATTWRDNARLWSSRPRRYVYLA
                     LCVPNGLIVGCESLFVPYAPQDAGPLFASAAAGMLAGDILTGRFLPTRWRRNLAAPLLV
                     LLAAPYALLALRPPLPAAMAAVALSALGYSASLLLQERLMCLTPSRLSGHALGLHTSGM
                     LTMQGVGAALAGTAAGLTSPATAMAVMATASVGVTLALSPGLPRGDRKRAVARPPAGRR
                     AAHRRVRR"
     gene            10001..10984
                     /locus_tag="AMK26_RS19190"
                     /old_locus_tag="AMK26_18920"
     CDS             10001..10984
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018569787.1"
                     /locus_tag="AMK26_RS19190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_18920"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_073755906.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.6e-16, bitscore:
                     56.4, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVDVERLLADCLQDARTASLGTLPLAAEGAAYAAARRTFLAAGLR
                     ALRDDLPETGWVQLGLAPWPDAWPDLYRRLAETAQELTGCGWADDFFFMHKPPGLRIRF
                     HAPRPAGVAALRAELLRRFDRQDGAWTSPTEGVYEPETYLFGGPRAMPLVHALFTADSL
                     AWLDHHAARGKEAPADWRVSLTLLRAVLDGLGVVGWEHRGVWQVVREETGRRLVDGLHD
                     ASRQRAAAGIRAYWNLPFEEQLDALPEAWRAGVRDHQEAVRRAASRWRTDYFEAGDALV
                     GPRRAAAHYAIFHWNRGRFSAARQSLLTEALASDGHGHGDRDEGAC"
     gene            10986..13643
                     /locus_tag="AMK26_RS19195"
                     /old_locus_tag="AMK26_18925"
     CDS             10986..13643
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018569786.1"
                     /locus_tag="AMK26_RS19195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_18925"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_073755907.1"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 3.8e-07,
                     bitscore: 26.4, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_N (E-value: 6e-20, bitscore:
                     66.5, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGENRIQGAEEGAGGTALLRIAGMPCAAWTSAADPALFDRVARHA
                     RAGEQRAARARELAERLGESVVPHPDLADTDRGAVLALRRRLHAGNAPQAADLGLLDRL
                     PRHAVAAEVTGQARALAYEAEQAHTERAELERAVADGQERAAARAWDLTRAHPVLRDIL
                     EGAAPGLLADVERRLAAGESWGGKRLRKRAAYIWRVLGRAAAKTTPRGWAGQLATAPVR
                     TQAPGTLLITPGSTLGALAATGTENVHLVRSRPPGPPDLRTADAGTLLAPAPLHFTEPS
                     SVRAYVVDPRQPGRLRHVVLRRTRALDTVLSLLADGPCPLGELEKTLLGAAAGAGTVHG
                     GTKDPSTKAPDPAVLRGFLQHLHTMGVLQVCTAPRLRHSTWTPPEEVTAHGTLPRPLAA
                     TDGDPAGWFLDSYRAPAAPVPAAAAERVRRGLRAAARIAALRDAGTTTAQEAPELAAIT
                     EQPRPVSEILAALLPTATGGPPPTTAVRRRYGGWPEPTAPESGYARLLAHLAAHTGPGP
                     ADVDDALLDALGAPPADDALPPWPLDCLLRPLPGEGSGPVAVLETASAAGVLDARFADG
                     LRALYGGHGNADAHRAFLAAVERHTGVRFVELLVPPLGERAANAVRRPVTTGWWTGDPD
                     PTPYYGPRGTGARYLPLDRITVRRSGRRIVAEADGHRVIPVHHATRTPAPPYDRLLRVL
                     LAAGHPAGSYLLRLDGLDGALPAHTRLPRLTAGGELVLAPATWRLDRARLWRPGDDALH
                     KVRALALLQRAHGLPRHAFLRTAAGAKPVPVDLDSLTALQVIDRLCAQQPGTGLLVEEM
                     LPAPGDLPLRDPLHGGAAIAAQMLLRLPYDTGVRAIEQLAEAAADALRRGAPQDVPDGP
                     PAAGGRSVGAAIAH"
     aSDomain        11850..12107
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_AMK26_RS19195_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.30E-08"
                     /identifier="RREFam001.1"
                     /label="AMK26_RS19195"
                     /locus_tag="AMK26_RS19195"
                     /protein_end="374"
                     /protein_start="288"
                     /score="26.4"
                     /tool="antismash"
                     /translation="DPRQPGRLRHVVLRRTRALDTVLSLLADGPCPLGELEKTLLGAAA
                     GAGTVHGGTKDPSTKAPDPAVLRGFLQHLHTMGVLQVCTAP"
     gene            13663..13815
                     /locus_tag="AMK26_RS37340"
     CDS             13663..13815
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019546722.1"
                     /locus_tag="AMK26_RS37340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_198944109.1"
                     /transl_table=11
                     /translation="MPGTMELTDLDTLIDELDERITDSELPAEQAYTAGCSGVCTIVIC
                     TAIVC"
     gene            13885..15057
                     /locus_tag="AMK26_RS19200"
                     /old_locus_tag="AMK26_18930"
     CDS             13885..15057
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010475290.1"
                     /locus_tag="AMK26_RS19200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_18930"
                     /product="lanthionine synthetase LanC family protein"
                     /protein_id="WP_073755908.1"
                     /sec_met_domain="LANC_like (E-value: 1.5e-21, bitscore:
                     72.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTPHDPVVDLSLAHLEKWTAQPHETPAPSDPGIPVLAHLVAATG
                     GPEATATAARAVAVWARTAGRGPGHPGLYDGGLAGTLVGLRLGARLHPALHRAADRLRD
                     HLTGEAVATVWRTADVAFPDYDLITGPAGILLALCAGADPKAPELHRPAHHLTALCDHA
                     DLWRLRTGQYADHPHLSWTQGRVNTGVGHGVAGVVTALTAALRYTGDPGAAQALRHATR
                     WLATRSYVDERGVRTWPGAGLDGPPPAGANPRQAWCYGTPGVAWALWDAADALGDREAA
                     DWALTAFGTLAERYDEGFHLFGDGPADLLGLCHGAAGVLAVADAFDRHAHLPAAAALGS
                     RLTAHLRARLPEALGTPWPPGLLTGAPGALSALLTARGAPRDWLPCLGLR"
     gene            15121..15966
                     /locus_tag="AMK26_RS19205"
                     /old_locus_tag="AMK26_18935"
     CDS             15121..15966
                     /GO_function="GO:0016407 - acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012995.4"
                     /locus_tag="AMK26_RS19205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_18935"
                     /product="arylamine N-acetyltransferase"
                     /protein_id="WP_073755909.1"
                     /transl_table=11
                     /translation="MSVKGFEGYLARLGVTDPGAPSAEALSALQRAHLERVPYENIDIQ
                     LGRPPGIEPELSVRRFAAGQGGYCFHLNGGFAALLEALGYDVTRHVGGVHQEPEGRGAN
                     GNHLALTVRVDGEAWFVDTGLGDGPYEPLPLRPGRYQQGPFTYRMEPSVTEPGGWTLHN
                     GPQSAFPVMEFAARPVTMADFADEHLRLSTAPDSPFLTTFAALRRDAKGLDLLRGRVLT
                     RIDTAGRTERPLDTAGEWYAALADVFGRNLDGLDADDRSALWERVTRAHEEWLAARATP
                     "
     gene            complement(15973..17301)
                     /locus_tag="AMK26_RS19210"
                     /old_locus_tag="AMK26_18940"
     CDS             complement(15973..17301)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016471172.1"
                     /locus_tag="AMK26_RS19210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_18940"
                     /product="hypothetical protein"
                     /protein_id="WP_073755910.1"
                     /transl_table=11
                     /translation="MGRRCLVLSASMGAGHDTVARELARRLRADGHEVLVRDVLTLLPP
                     GTGPAMRGFYRFVVRRLPPVYAAIYALFLAPRPRSRGGRPRRGLDVSPMAALAERRLGA
                     LVARWRPDVIVSTFHLAGQITGRMRGRGVLRVPCAVFVTDFAVHRAWLDPGNDLYLCVT
                     ETAARAAREGTGRTAIATGPVVPPEFHEAGAGPRAPEAGAPAAGAREAGARKAGAPAAG
                     AREAEAREAGAPEAGAREAGAPGPGQPDGSGTRSTSTAGRQERGAGGAGDADADGRPVV
                     LLSGGAWGVGPGLLHTAGALARHGFLPVLLCGRDERLRRRASRLPGVRALGWTDDMPGL
                     MASARALIDNAAGQTAVQALAAGLPVVGHRPIAGHGAVGVREMAAEGLTVYASGLPALL
                     AAVGELAGPGPAREERAAAGSAVFRADAARLVADLAEAAHATG"
     gene            17496..18308
                     /locus_tag="AMK26_RS19215"
                     /old_locus_tag="AMK26_18945"
     CDS             17496..18308
                     /NRPS_PKS="Domain: PKS_KR (25-186). E-value: 9.4e-18.
                     Score: 56.7. Matches aSDomain:
                     nrpspksdomains_AMK26_RS19215_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010468147.1"
                     /locus_tag="AMK26_RS19215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_18945"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_079277681.1"
                     /sec_met_domain="adh_short (E-value: 2.7e-33, bitscore:
                     111.2, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPTPRREAAPGRARSTGGEPVARPVVLVTGASSGIGEAIADRFA
                     DDGRCRLLLGGRDEERLAAVARRTGGGALRADLAERAGVERLAAEALEREGRVDVLVAA
                     AGIGWAGPFTRMPADAVDRLIAVNLTSVVHLVRLLLPPMAERGAGHLVMIGSMAGRVGV
                     ANEAVYATTKGGLLAFADSLRYELAGTRVGVTVVLPGAVDTPFFTTRGVPYHRDHPRPV
                     PAERVAEVVWRAVARGRDDVFVPGWLAMPARMHGAVPGFFRAMAKRFG"
     CDS_motif       17571..17666
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMK26_RS19215_0001"
                     /evalue="2.30E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="AMK26_RS19215"
                     /protein_end="57"
                     /protein_start="25"
                     /score="20.2"
                     /tool="antismash"
                     /translation="VVLVTGASSGIGEAIADRFADDGRCRLLLGGR"
     aSDomain        17571..18053
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMK26_RS19215_PKS_KR.1"
                     /evalue="9.40E-18"
                     /label="AMK26_RS19215_PKS_KR.1"
                     /locus_tag="AMK26_RS19215"
                     /protein_end="186"
                     /protein_start="25"
                     /score="56.7"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVLVTGASSGIGEAIADRFADDGRCRLLLGGRDEERLAAVARRTG
                     GGALRADLAERAGVERLAAEALEREGRVDVLVAAAGIGWAGPFTRMPADAVDRLIAVNL
                     TSVVHLVRLLLPPMAERGAGHLVMIGSMAGRVGVANEAVYATTKGGLLAFADSLRYE"
     gene            18314..19192
                     /locus_tag="AMK26_RS36225"
                     /old_locus_tag="AMK26_18950"
     CDS             18314..19192
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018468727.1"
                     /locus_tag="AMK26_RS36225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_18950"
                     /product="DMT family transporter"
                     /protein_id="WP_073755912.1"
                     /transl_table=11
                     /translation="MLALSICLALLAALGNAGASVLQRQGAAATGPTPASARRGSWMAG
                     LVHRRVWVWGAALLAVSGILQALALATGPLSVVQPVMSTELMFTLVVGGVVFRRRPDTR
                     TKWAFAAMALGLAVFLAMADPTGGRSTVPVADWVWTALGAGAFVAFLGVVALRLSPAPR
                     AAVLGTATATGFACTAALLKDALGRLPDGVGAVLTTWQPYAAVGVGLASFVLLQVTLRA
                     GSLVASQPALTLGDALLSVVLGVTLFAERVHLGWRVVFEALALAVLVAGCVQLARSPLV
                     TDDPERPEERW"
     gene            19186..19902
                     /locus_tag="AMK26_RS19225"
                     /old_locus_tag="AMK26_18955"
     CDS             19186..19902
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005321186.1"
                     /locus_tag="AMK26_RS19225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_18955"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_073755913.1"
                     /transl_table=11
                     /translation="MVNSLPAAALGAVAAWHIGPAATWLPGVRAALWPGLDGRGDPSHV
                     ALTFDDGPDPDSTPEFLRALDALSVRATFFVLGSRLARRPALGRLIAAEGHELAVHGWQ
                     HDRPWCPRPLRDTRDLARTADLVADAAGRRPLWYRPAYGILTGGRWTAARAAGLRTVLW
                     SAWGRDWTAGATARSVHAEVTRTLRGGGTVLLHDSDVVSAPGAWRAALGALPGLVAECR
                     SRGLEVGPLRDHDVIE"
     gene            19936..20562
                     /locus_tag="AMK26_RS19230"
                     /old_locus_tag="AMK26_18960"
     CDS             19936..20562
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019526757.1"
                     /locus_tag="AMK26_RS19230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_18960"
                     /product="alpha-ketoglutarate-dependent dioxygenase AlkB"
                     /protein_id="WP_073755914.1"
                     /transl_table=11
                     /translation="MAAHLQGSLFDQTDEIRLGPLTGVRRTALGDGAWIDLLPGWLHGA
                     DALFEELAEGVPWRAERRQMYDHEVAVPRLLAFYGAADTLPHPVLDEARTALSAYYAAE
                     LGEPFTTAGLCYYRDGRDSVAWHGDRIGRGSREDTMVAILSVGEPRDLALRPRGGGPSR
                     RVPLGHGDLIVMGGSCQRTWEHAIPKTTKGAGPRISIQFRPRGVG"
     gene            complement(<20575..21240)
                     /locus_tag="AMK26_RS19235"
                     /pseudo=""
     CDS             complement(<20575..21240)
                     /GO_function="GO:0004089 - carbonate dehydratase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018510643.1"
                     /locus_tag="AMK26_RS19235"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="carbonic anhydrase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLRAALGGTAALGFAPAPAVAAPRPGSARPGTPVEAWRELVHGNK
                     RWRARHQAHPHEGVEDRTAAVAGQHPFALILGCVDSRVPPELVFDQGLGDLMTVRSAGE
                     VLDEAVLGSIAYGVLELGIPLVVVLGHQSCGAVAAAVKADETGEEPPAHIDYIAERIRP
                     VIDRSHTGAARIDATITANVRHVRALLAAEPDLAARVEARRLAIVGARYELGSQLVHHV
                     "
     misc_feature    21290..21300
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: strong, score: 22.05"
                     /tool="antismash"
     misc_feature    21380..21395
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.91"
                     /tool="antismash"
     gene            21505..24249
                     /locus_tag="AMK26_RS19240"
                     /old_locus_tag="AMK26_18970"
     CDS             21505..24249
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020551468.1"
                     /locus_tag="AMK26_RS19240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_18970"
                     /product="SpoIIE family protein phosphatase/ATP-binding
                     protein"
                     /protein_id="WP_241837968.1"
                     /transl_table=11
                     /translation="MVHFFDRFRGASVRSLADRRPRSVAGQVFVLQVALVVLLVLGAVL
                     ALLLQSRGDSDREARNRSIAVAESFAHSPGLENVLKTHPDPSSVLQPLTETARARAGVD
                     FIVVMDTRGIRYTHPQPERIGGRFVGTIEPSLAGRVHTESVDGPLGEEVQAIVPVRGSD
                     GTVIGLVSAGLEVRNVTGVVNRQLPVILATAAAGLAVATAGSALVARRLRRQTHGLGPA
                     EMTRVYEHHDAVLHSVREGVVIVGGDGRLLLANDEAERLLQLPPDAEGRTVKDLPGLDR
                     GMAELLCSGRVATDEVVPAGDRLLAVNQRHTDRHGGPAGTVATIRDTTELRSLTGRAEG
                     ARRRLNLLYDAGVGIGTTLDVVRTAEELAEVTVQRFADFVTVDLADPVLRGEEPSGTAA
                     DMRRTAVAGIRDDHPLYPRGKMIGFVPSTPQARGYGSGRAELVPDLSKAPGWQAQDPER
                     AARIVQYGIHSLIAVPLKARGVVLGVANFWRSEKPEPFEDEDLALAEELVARAAVCIDN
                     ARRYTREHAMAVTLQRSLLPRALPEQSALEVAHRYLPAQSGVGGDWFDVIPLPGSRVAL
                     VVGDVVGHGLHAAATMGRLRTAVHNFSTLDLPPDELLGRLDDLVGRIDQDEDEDDTGAA
                     GMTGATCLYAVYDPVSRRCSMARAGHPLPALIHPDGDVEFPDLPAGPPLGLGGIPFETA
                     ELDLAEGSQIVFYTDGLIEDRTRDIDVGIELLRKALGRPAATPEDRCQLVLDELLPAHP
                     KDDVALLVARTRALAGDRVADWDVPFHPGAVGGIRSAAVRKLTEWGLDDLSFAAELILS
                     ELITNAIRYGAAPVRVRLLYDRGLTCEVADNNSTSPHLRYAATTDEGGRGLFLVAQLAE
                     RWGTRYTAHGKVIWAELPLPGTGSSSGDGTGTLPFDVFNAGLI"
     gene            24259..24990
                     /locus_tag="AMK26_RS19245"
                     /old_locus_tag="AMK26_18975"
     CDS             24259..24990
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015606999.1"
                     /locus_tag="AMK26_RS19245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_18975"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_073755916.1"
                     /transl_table=11
                     /translation="MFTAHGPTLRELAAQALSSTQTGYDLLAPKFHHTPYRTSDGVLGA
                     VADALRPLGPFRAGLDVCCGTGAGVGVLRELCQESVTGVDFSAGMLDQARAAHADANGG
                     APGVHWVRADARALPFRSAFDLAVSFGAFGHFLPEERPRLFAGVHRALRPGGRFVFPIP
                     APPPVGSLPYWELWAFDAAMRVRNLLWRPRFIMYYRTLRLTDVVTELTRTGFTVDLTPL
                     EEFGRRPDGSPRCRMVTALRT"
ORIGIN
        1 gggaagtacg gggcccccgg cggcacttcg tccactccaa gatcatgtcg tgggtcgcgg
       61 ccgaccgcgc cctgcgcatg gcccgggtcg ccggactgcg cggctcggcc gagcgctggc
      121 gcgcgctgcg gcaggagatc cgcaaggacg tcctgcacca cggctgggac ggcgaactcg
      181 gctgcttcgt gcagtactac ggctcacggc ggatcgacgc ggcggccctg ctcatgcccc
      241 ggctcggctt cctccccccg gacgaccggc ggctgcacag cacgctggag gccacccggc
      301 tgctcgacga ccacggcttc ctgcggcggt acgccgactc gggcggcgac gaccgggtgc
      361 acgaggtcga cggactgtac ggcggcgagg gcacgttcct ggcctgctcg ctctggttcg
      421 cggactccct ggccctcacc ggccgccgtg aggaggcccg ggagcagttc gaacgcgtcc
      481 tggcggtacg caacgacgtc gggctgctgt cggaggagtg ggaccccgtg gccggccgcc
      541 agctcggcaa cctgccccag gccttcagcc atgtggcact ggtcaacacg gcgttcgccc
      601 tgcacggcac ccgcacgggg agccgcaacg gcaccggcgg ccggcacggc gacgggagcc
      661 gcgcggagag cggctcccgt gtgcgggcgg cccgctgagg gcatcgcccg tcatgtgccg
      721 ttggtcgcgt cgggctctct ctgccgacgc agcacggccg caccggccaa ggccgcggcc
      781 agcgcggcgg acatcaccgc cgcggcgctc gcccaggcgt acggcgcgcc cacactgcca
      841 cccagcgggt cgaagtcgct tccgcccgcc accgcgtgca gggcgaccac cccgatggcc
      901 gtcgctcccg cggccgccca tactcgcacg gtgtcccgca cgccgagcca cagcccgagt
      961 accaggcaca gcacggtcac ggcgaaggcc agggtgtcgg cgttcccgcc ggaccgcagc
     1021 cccgcgaggt ccgtcggcag gtggatgacg ccgcaggcga acagggcggc cgccgcgggc
     1081 caccgcaggc cggaacgcag ggcgggggag gccgactcgc gggccaggtc ggccacggtg
     1141 accggctgct ccagcgacgg agtcaccgaa gcggaccgcg gcggacggac gttggggttc
     1201 tccggtacgg cgatggggcc ctcacccgcc ttcatggcgg gaccgggtgc cgacgcggag
     1261 gccgccgccg gcgccggccg cgcgcctgcg tcaccggtgc cgaggatgct caccagttcg
     1321 gcgacgtcct cgatgggtct gccgacggcc gcggcacgca gcgccgtatc ggcctcgtcg
     1381 agcgggtggc ctgcctcgtt cagcatggcg accagctgcc gtacctcttc caggggccgg
     1441 accaccgcgg ccgcgcgcag cgcctcgtcg gccgggctgg agaccgctcc tgtgctcttg
     1501 agcagggcca ccagcgcggc gacctcctcc agcggccggt aggtggccgc cgtccagagc
     1561 agtgtcctta tgggctcgtc gctgtcgtcg ccgtccgcgc cggcgctctt ggagccggcg
     1621 agaacggcat ccaccagcgc ggcgtccacc ggcccggcgg cggcgcgcac ggcgtcggcg
     1681 gtacgtgtgg cgtccgtgga cgccgcgtcc gcctccgcct ccctctccgc ctccgtgttc
     1741 ctgtccgtgt ccctgccggt gggtgtgggt gcggcgggcg cggacccggt cgcccgctcg
     1801 gtcacggcgg gaggcaccgc ctccgggcgc gcggcctcga acggcgggtt ctccgggcgc
     1861 ggcggcacgg tgccggggaa gccggcggtg aaggacccgc tcccggggcg cggggcatcc
     1921 gggtacgtgc cgttcgcgtc cgtaccgctc cggtacgtgc cgttcgcgtc cgtgccgttt
     1981 gtgtacgtgc cgttcgtgtg caccgtcctg gactgcgcgg tcccggcatg cgggtcggcc
     2041 gggtgcgcgg tctcgacggg cgtttcgccg gccggtgacg cggcaccgag ccgtacggcg
     2101 tccgcgtacg cggcgtcgac gggtgtggtg gcgggcgggg tgaccgggcc ggtggcgggg
     2161 tcgggcggac cgggcggctt cgcccggtca gggaccgccg ccctggcggg agttgtgggg
     2221 tcgtcggttg tcatggcgtg gctccgttcg ccggactccg gtgaggcaca caccgtgtcg
     2281 gtcgtcgtgc gccgctgggg cgcgcggttt gctccatcta atgggcaagc cgggcaattg
     2341 cgccatccgg gaagggcgga cggggtaccc cggccccatc tcgcccccac gagggcccca
     2401 ctaggtgaaa tctgtacgac aacgttgaat attcgccatt tgcaccctat gtccgactgc
     2461 ggtccactag aagtggaaga aggcattcct ttccgcatga agggatggcg gtatgacgtc
     2521 aaccgagtac gaactccggg accgtacgaa gatcctggac agcgacatcg aagaagccct
     2581 caacccgggt gaagccgcag gcttctaccg tgacacccgt gaatgcggga tcctggccct
     2641 ggaggccggc gcaggcaagc tcctgttgtc gcctccgacg ccacgcccga agaagggttg
     2701 acagggcagt cgagcggtcc ggcgccgcaa gccgtccggc ggcgcggtgc cgaggcccgc
     2761 tcccacgtgg tccccgctct cgcgtgcggg ggccacgctc tgtttcccgg accgacgcct
     2821 tccgccgttt gcgaccactg ccggactggg gtccactgga agtggaagaa ggcattcctt
     2881 tccgcatgaa gggatggtgg catgacgtca accgagcgcg agctccggga ccgtacgaag
     2941 gttctggaca gcgacatcga agaagccctc aacccgggcg agctctcagg cttctaccgc
     3001 aacacgcgcg aatgcgcggg gctggccctg caggccggtg cgggcaagct gctgctgtcg
     3061 cccccgacac cgcggcccaa gaagggttga aagggcaact gaatggagca gcccggcact
     3121 tcgaccccgt tgatgggcgc ggtgcaggag ctcgcaaccc aggtggtctc tgctctcacg
     3181 agcgggggcc actcccgagt gtccgccggt acggcggtca ccatcgggga cgacgacctc
     3241 ggcctcgccg cggtacgcgt cctgggagcg gacgtcctgc tgccgagcgt cctgtaccgc
     3301 cgcccgcccg cccccgtcga cctggcggtg tgcgagaagg cggtcctcgc ctacccgccc
     3361 gcccccgacg cctcggccac ctcgcgctgg acccactggg ccatgacccg cacgctgcgg
     3421 gacctgggcg cctccgccgc cgtggagtcc cccgacggcg ccgagccgga cgccacctgg
     3481 ctggaggatc tgccctggca ggccctgacg caccagctcg ccctcttggc cgcactcgcc
     3541 gttcccgcgg ccggcagcac ggcccacagc acggccggca gcatggccga ctgcgcggtt
     3601 gcccatgtcg cgggacgccg cgtggtcgac gtcgcccggg gcttcgtacg agccgtacgc
     3661 cgccgcggct ggcagcaggc ggccggcgcg gggcgctggc tggccgtgct cgacggcgtg
     3721 cccgacacgc tgggcctgga cgcgggcctg gagttcgtgg cccagatggg cggcgacgac
     3781 ccacgggtgg cactgcacct gcacgcggcg cgccacgcac gggccggagc cccggggtga
     3841 cggcgacgga cgtgcggcgc gtggccgagg ccgccctggg ctggctgtcc gacaaccgcg
     3901 acggcttccg gctcggcgac gacgcgctgg aacccgacgc cgacgtcaac agctcctgga
     3961 agcccctggg cgaactggcc cagacgtgcg tctgcgtacg ccgtcacacc cctcccggct
     4021 cggccctcca cgacaccgcc tccgacctgc tggaccacgc ctggcaccag acccgcgacg
     4081 gggcactctt cctcgacctg caacgcctcg aaccgtgcgc cacctacccc ctggaggtgt
     4141 acgccgcgtt cgcctcgggc ggcctgcggc accgcgcgta cgaggacttc accgccgcac
     4201 tcctccgcac ccgcagctgg cgcaccacgg aactgctgcc gaaccggctg ctcagcatcc
     4261 tcaactcgga gcggcgctcg ggcttcaccc cccacgaggc gaccgccgcc gtcctgcgcc
     4321 gcacctggct gggcggcctg cccgagccgt ggttgttcga gcggaccgcc ggatacaccc
     4381 tcacccacgt cgtgtaccac ctcacggact ggggccacga cgtggacggc gtaccggcgg
     4441 acgtcgcggc ctacctggac acctggctcc cggcctggct cgacggctgc gtggagaccg
     4501 aacactggga cctgtgctgt gagttgctcg ccgtcgcggc cggactgccc gagcccctcc
     4561 cgccggagct gaccgaggac gcctgggcgg cggtggcccg ggcccaggac gatacgggcg
     4621 ctctgaccga gatgggccgc ggaccgcgcg gcgaggaggt gctgcgggtc ttcgccaact
     4681 gctaccactc cacgctggtc gcggcgttcg cggccaccct gaccgcggcc cgccgcccgg
     4741 ccggccggag caccgacgac acccaccgag gagtgccggc atgagcgccg ccagtacccg
     4801 cctcgtccac acggtcggag tgggcgccat cgagtggctc cacgaacacc gtgacggatt
     4861 ccggctggaa ccggacgtcg acccggagat cggcttcctc gagcggttca aaccggtcgg
     4921 cgaactcgcc gtcatctgca aggtgctctt ccgtgaagga gtggcgggct cccgccaggc
     4981 cgacctcgcc cgccggctgc tcgaccacgc ctggcgcgac gtcctggacg gcggccggat
     5041 gctggtacgc ggccagcgca ccgaaccgac ctccccgatc cccttcgagg tgtacgtccc
     5101 gttccgggag ctcggctaca gccagcccga actggagcgg gcgatccggc tcaaccaccg
     5161 gctcaccggc tggggtgccc tggaggtgca gcccgtccgg cgcctcggcc tgagcgcgtt
     5221 cgagcgccgc ttcgggctga ccgcgagcct gcccgaggac gtggccctca gccgtacgtg
     5281 gctgggccac acccccgaac cgtggaccgt ctccgcgcac accgcgtacg acatcaccca
     5341 caccgtcttc cacctcaccg actggggcga gaaccccgcc gggctgccgc cccgcatcgc
     5401 gagccacctc gacctctggc tgccggtctg gctggacgac tggctcgacc tggagcgctg
     5461 ggacctgctc ggcgaactgc tcgtcgtcga cgcctgcctg ccccgcccca cgctcgacgc
     5521 gcgcgcgtgg gaaggcttcg ccgccgccca gcagccggac ggcgccatgc ccgcgctcgg
     5581 gcccatgccc gacggcgacc ccgacgacgt cttcgacatc gtgtaccact ccacgctggt
     5641 cgccgccttc gcctccgtcc tggccacctc ccgcgccctc gcgcagctca ccgcggaggc
     5701 ccccgcatga ccgcggacgc gcaccgcgcc gcccccggcg accacgagca ccacgagcac
     5761 caccaggacc gcgacgacgc cggcgcgcgg ctggaggagg ccgtacgggc ggtcgacgca
     5821 cccgacgtcg tcctcgctct ctcccgccac ggccgccgca ccgtccgctg cggcggcacc
     5881 gcgccgccgc cgcccgtccc gcgcgaccgc ctgcgctacg agctcggatc ggcgtccaag
     5941 acgtacaccg gcctgctgct cgccgacctc atccactccg gcacgctgtc cggcaccgac
     6001 ccggccaccg ccctcctgga cccggccagg ccccccggcc gccaccccgc caccctcacg
     6061 cacctgatga cccacacctc cggactcccc ccgctgccag ccgacttcta cccccaggcc
     6121 ctgccccgct ggtacaccaa cccctacgcc cactaccccg ccgaacgggt cgtccgcgcc
     6181 ttcctccgcg cccgcccccg ccaccggccc ggcagccggt ggcgctactc caacttcgcg
     6241 gtcgccgtcc tcgggcacac cctcgtcgcg gccaccgcca ccccctggga acggctcctg
     6301 accgactgcg tcctcggccc cctcgggctg gtggacaccg cgctgcgccc caccgggccg
     6361 gacaccgacg ccaccggtca ccgactggac ggcaccaccc ccaccccgcc cctgcacatc
     6421 ggcggcttcc aggcggccgg cgcgctccgc gccaccccgt acgacctgct caccttcctg
     6481 gaagcgcatc tgcgcccgga acgctccccc ctggccgccg cgctgctgga ggtgcgccgc
     6541 ccgctgctgc ggcgcgggcc cggccgccgg gagacgcaca cgctggcctg gttccaccac
     6601 cccgccgagg gcggcaccat gtacttccac atcggcgcca cctgcgggca gaccgccttc
     6661 ctcggcttcc ggcccgacac cggcaccgcg ctcgccggcc tcgccacccg ccgctacagc
     6721 cgcaaggaca ccctcgtacc gaccgcctac gcgctgctca gctcatcgga ggaccaccca
     6781 tgctgaccac cgacttcgta cccggcacac ccaactggat cgacctcggt gcccccgaca
     6841 ccgacgcggc cgtcgcgttc tactccgccg tgttcggctg gacgttccag tcggccggcc
     6901 cggaggccgg cggctacggc ttcttccagc gcgacggcgg tacggtcgcc gccctcggcc
     6961 cgctcaccga ggagggcgcg agccccgcgt ggacgccgta cttccacacc cccgacgccg
     7021 acgccacgag caaggccgtg gaacaggcgg gcggtacggt ccgcgtcccg cccatggacg
     7081 tcttcaccgc cgggcggatg gccgccttca ccgacccgac gggcgccgac ttcgccgtgt
     7141 ggcagccggg cgacaccaag gggctggaca cggtcatgga acccaacacc ctgtgctgga
     7201 ccgagctcta caccaccgac gcggcggccg ccaaggactt ctaccgctcg gtctgctcct
     7261 ggcagtacca ggacatggac atgggcggcg gcatggtcta ctccgtcgtc tcctcgccgg
     7321 gcggcggcac ggacgacgac cccggacagg gcggcatcat gcaactccag gaggagaacc
     7381 tcgccgccgg ctccggctcc gagtggcacc cgtacttcgg cgtgaccgac tgcgacgcca
     7441 ccttcgccac cgccacggaa cacggcgcca cgcccctggt cgcgcccatc gacgccccgg
     7501 gagtcgggcg gctcgccatg ctgatggacc cctcgggtgc cccgttcgcc ctcatcaagg
     7561 gcgaccccac cacgacctga cccatggagc cgcctcgtca accgtccccc tgctgcgccc
     7621 gcaccagcgc ctcgccggcg tccgagcggt agtacagcac cgaccgcccg gcacgccggc
     7681 gccccaccag ccgggcgtcc agcagcacct tcaggtgacg gcccaccgac cccaggccct
     7741 gcccggtcag cgccaccaac tgcgtcgtgc tcttcggcgt gtccagcagg accagcacac
     7801 ccgcccgcgc cggacccagc agcgcggcca gcgcgtgcgg cacgcccgcc gccccgccgc
     7861 cgctcccgtc cgccaggacg cccgcgcacg ggtacaccac ggcgtaccgg tgcggggcgt
     7921 cccacgagca ccagctctgc cggggcgtga ccggcacgaa catcagccgc gccccggaga
     7981 tctcccgcgg cggataggcg tacgtactga cctggagcgg tccccgccca gccaccgcat
     8041 cccggaccgc atgccgtcca gcgcgcccgc ccagccggcc cggcccagcc gcgccgtacg
     8101 cgccacgaca tcggcctcca gcacccggcg ccgccgcggc cacgacggca ggaccgtacg
     8161 cgtccacacc caggccagca gctccgccgt ccgctccggc aggtcggagc ggtgcagccg
     8221 ggccggcagc ggcccgccca gcgacacggt cagatccgcg cgggcggtcc cgggcggcca
     8281 cgtacggatc cgctccacct cctcctcgaa cacggcctcg ccctcgccac cgggcgtggg
     8341 cgtcaggaag tccgcgttcc aggtgcgccc gagggccgcc cgtacgagca gcgcggtgac
     8401 cgggtcgccg gccagccgct cccggtaggc gggcaggtgc gcgtccagcc acccgcgctc
     8461 gcccggatgc gcggccgtac cccgttccag ggtcttcagg cacgcgatgg cctcggcgag
     8521 cggcgacacc acgaaccggc tgccggcgag cgtgtccgcg ttgacttgcc accagcccat
     8581 gcgcaccccc gtgtttcgcg tgagcgcgaa acagtaacgg ccccgccgcg ccgcctccca
     8641 gactccggac atgcgcacct accgcgaact cttccgcacc ccggagttca cccccctctt
     8701 cctcgcctgc gccgcgcagg tggccgccca gaccgtcagc ggcctcgccc tgagcaccct
     8761 ggtccaccgg gcgaccggct ccgcgctgct gtccgcgctc gccatgttcg gtcccgccct
     8821 cgcccaggtc gtcggcgcca cgacgctgct gtcggcggcc gaccggctgc cgccgcgcgc
     8881 cgcgatgacc ggcctggccg tcctgttcgg cctcggcacc gccgtacagg cgatccccgg
     8941 tctgcccgtg tgggcgctct tctccgtcct cgcggtcctc ggcgtgctgg ggtcgctggg
     9001 cggcggagtg cgctacgggc tgctgaacga gatcgtcgcg aaggacgggt acctgctggg
     9061 ccggtctttg ctcaacacgt ccgtgggcgt cacgcagatc tgcgggttcg gcgtcggtgg
     9121 cgtgctcgtc accaccgtgt caccgcgcgg cacgctcctc accggcgccg cgctgtacgt
     9181 ggccgccgcg gccgtcgccc ggttcgggct cgcccgccgg ccgccccgcg ccgccggacg
     9241 ggcctccgtc gccacgacgt ggcgcgacaa cgcccgcctg tggtcctccc gcccccgccg
     9301 gtacgtctac ctcgccctat gcgtgcccaa tgggctgatc gtcggctgcg agtcgctctt
     9361 cgtgccgtac gccccccagg acgccgggcc gctcttcgcg tccgccgccg ccgggatgct
     9421 ggccggtgac atcctgaccg gcaggttctt gcccacccgg tggcgccgga acctcgccgc
     9481 cccgctgctg gtgctgctcg ccgccccgta cgcgctcctc gcgctccgcc cgcccctgcc
     9541 ggcggccatg gcggccgtcg ccctctccgc gctcggctac tcggcgagcc tgctgctcca
     9601 ggagcggctg atgtgcctga cgcccagtcg actcagcggg cacgccctgg ggttgcacac
     9661 ctccggcatg ctcaccatgc agggcgtggg cgccgccctc gcgggcaccg ccgccggact
     9721 cacgtcgccg gccacggcga tggccgtcat ggccaccgcc tcggtggggg tcacccttgc
     9781 cctctccccg gggctgccac gcggcgaccg gaagcgtgcc gtcgcccgcc cgcccgccgg
     9841 gcgtcgggca gcccaccggc gtgtgcgccg gtaggtgcgc ggagagcgac tccgagcccg
     9901 cgcacctcag ttgattgtat gactagcttt tgtcgtgctt tcggacgacg gcggcccgga
     9961 catccactgg gaggaagcga cacccttcgg aggaggccgc atggtggacg tcgagcgact
    10021 gctggccgac tgccttcagg acgcgcgtac cgcatccctc ggtaccctgc cgctcgccgc
    10081 ggagggcgcc gcgtacgccg cggctcgccg cacgttcctg gccgccgggc tgcgggcgct
    10141 gcgcgacgac cttccggaga ccggctgggt ccagctcggc ctggcaccgt ggccggacgc
    10201 ctggcccgac ctgtaccggc ggctcgccga gaccgcccag gaactcaccg gctgcggctg
    10261 ggccgacgac ttcttcttca tgcacaagcc gcccggtctg cgcatccggt tccacgcccc
    10321 ccggccggcg ggcgtggccg ccctgcgcgc cgaactcctc cgccgcttcg accgccagga
    10381 cggcgcctgg acgagcccca cggaaggcgt gtacgagccg gagacctacc tgttcggcgg
    10441 cccgcgcgcc atgcccctgg tgcacgccct gttcaccgcc gactcgctgg cgtggctgga
    10501 ccaccatgcc gcacgcggca aggaagcccc cgcggactgg cgggtgtcgc tcacgctgct
    10561 gcgcgcggtc ctggacggcc tgggcgtcgt gggctgggag caccggggcg tctggcaggt
    10621 cgtacgggag gagaccgggc gccgtctcgt ggacggcctg cacgatgcgt cccggcagcg
    10681 ggcggccgcc ggtatccgcg cgtactggaa cctgcccttc gaggagcagc tcgacgccct
    10741 tccggaggcc tggcgcgccg gtgtgcgcga ccaccaggag gctgtccggc gggccgcgtc
    10801 ccgctggcgc accgactact tcgaggcggg cgacgcactc gtcggtccgc gccgggccgc
    10861 cgcccactac gccatcttcc actggaaccg gggcaggttc tccgcggccc ggcagagcct
    10921 gctgaccgag gcgctggcct ccgacggcca cggccacggc gaccgtgacg aaggggcctg
    10981 ctgacgtggg ggagaaccgg atccagggcg cggaggaggg cgcgggcggt acggcactgc
    11041 tgcggatcgc gggcatgccg tgcgcggcct ggacctccgc tgccgacccc gccctgttcg
    11101 accgggtcgc gcgccacgcc cgcgccggtg aacagcgggc cgcccgcgcc cgggaactgg
    11161 ccgagcggct cggagagagc gtcgtgccgc acccggacct ggccgacacc gaccgcggag
    11221 ccgtactggc gctgcgcagg cgcctgcacg ccggcaacgc cccgcaagcg gcggacctcg
    11281 gcctcctgga ccgcctcccg cggcatgccg tcgcggccga ggtgaccggc caggcccggg
    11341 cgctggcgta cgaggccgag caggcccaca ccgaacgggc cgagctggaa cgggcggtgg
    11401 ccgacggtca ggaacgggcc gccgcacggg cctgggacct cacccgcgcc caccccgtcc
    11461 tgcgggacat cctggagggc gcggcccccg gcctcctcgc ggacgtcgaa cggcgcctgg
    11521 cggccggcga gtcgtgggga ggcaagcggc tgcgcaagcg cgccgcgtac atctggcgcg
    11581 tcctgggccg cgcggcggcc aagaccaccc ccaggggctg ggccggccag ctcgccaccg
    11641 ccccggtccg tacgcaggcg cccggcaccc tgctgatcac ccccggcagc acgctcggcg
    11701 ccctcgccgc caccggcacc gagaacgtcc acctcgtccg ctcccggcca cccggaccgc
    11761 ccgacctgcg caccgccgac gccggcaccc tgcttgcgcc cgcgcccctg cacttcacgg
    11821 agccgtcctc cgtacgtgcc tacgtcgtcg acccgcgcca acccggccgg ctgcgccacg
    11881 tcgtcctgcg ccgcacccgc gccctggaca ccgtactgag cctgctcgcc gacgggccgt
    11941 gcccgctcgg cgaactggag aagaccctgc tgggcgcggc ggcgggcgcg ggcaccgtcc
    12001 acggcggcac caaagacccg tccaccaaag cccccgaccc tgccgtcctg cgcggcttcc
    12061 tccagcacct gcacaccatg ggcgtcctcc aggtctgcac cgcgccccgg ctccgccaca
    12121 gcacctggac accgcccgag gaggtcacgg cgcacggcac cctgccacgg ccgctcgccg
    12181 ccacggacgg agacccggcc ggctggttcc tcgactcgta ccgcgccccg gccgcccccg
    12241 tacccgccgc ggccgccgag cgcgtacggc gcgggctgcg cgccgcggcc cggatcgccg
    12301 ccctgcgcga cgccggcacc accaccgcac aggaggcgcc cgaactcgcc gcgatcaccg
    12361 aacagccgcg tcccgtcagc gagatcctcg ccgccctgct ccccaccgcc accggcggcc
    12421 cgcctcccac cacggcggtg cggcgccggt acgggggctg gccggagccc accgcccccg
    12481 aatccggcta cgcccggctg ctggcccacc tcgccgccca caccgggcct ggaccggccg
    12541 acgtggacga cgcgctcctg gacgccctcg gcgccccgcc ggccgacgac gccctgccgc
    12601 cctggcccct ggactgcctg ctgcgcccgc tgcccggtga gggctccggc cccgtcgccg
    12661 tgctggagac cgcctccgcc gcgggcgtgc tcgacgcccg gttcgccgac ggcctgcgcg
    12721 ccctgtacgg cggacacggc aacgccgacg cccaccgcgc cttcctcgcc gccgtcgaac
    12781 ggcacaccgg cgtacggttc gtcgaactgc tcgtcccgcc gctcggcgag cgcgccgcca
    12841 acgccgtacg ccgcccggtg accaccggct ggtggaccgg cgaccccgac cccactccgt
    12901 actacggccc ccgcggcaca ggcgcgcgct accttccgct ggaccggatc accgtgcgcc
    12961 gcagcggccg ccgcatcgtc gccgaggccg acggccaccg cgtcatcccc gtccaccacg
    13021 ccacccgcac ccccgccccg ccctatgacc ggctgctacg ggtactgctc gccgccggtc
    13081 accccgccgg ctcgtacctc ctgcgcctgg acggcctgga cggcgccctg cccgcacaca
    13141 cccggctgcc ccggctgacc gccggcggcg aactggtcct cgccccggcc acctggcggc
    13201 tggaccgcgc ccggctgtgg cggcccggcg acgacgccct gcacaaggtc cgcgccctcg
    13261 cgctcctgca gcgcgcgcac ggactgcccc gccacgcctt cctccgtacg gccgccggag
    13321 ccaaacccgt gcccgtggat ctcgactcgc tgaccgccct gcaggtcatc gaccggctgt
    13381 gcgcccagca gcccggcacc ggactgctcg tcgaggagat gctccctgcc cccggcgacc
    13441 tgccgctgcg cgacccgctc cacggcggcg cggccatcgc cgcccagatg ctgctgagac
    13501 ttccgtacga caccggtgtc cgcgccatcg agcagctcgc cgaggccgcc gccgacgccc
    13561 tgcggcgcgg cgccccccaa gacgtccccg acggtccgcc cgcagccggc ggccggagcg
    13621 tcggggcggc catcgcccac tagcgcgaga agggaaccaa ccatgcccgg aaccatggaa
    13681 ctcaccgacc tcgacaccct catcgacgag ctcgacgagc gcatcaccga cagcgagctc
    13741 cccgccgagc aggcgtacac cgcgggatgc agtggcgtgt gcaccatcgt catctgcacc
    13801 gccatcgtct gctgaccgca caggagccgc ccggcgcgtc cgggcggctc cgcccacccc
    13861 ggcccgcgac gtacgaggag cccgatggac accccgcacg acccggtcgt cgacctctcc
    13921 ctcgcgcacc tggagaagtg gacggcgcaa ccccacgaaa caccggctcc gtccgacccc
    13981 ggtatccccg tcctcgccca cctcgtcgcc gcgaccggcg gccccgaggc caccgccacg
    14041 gcggcccgcg cggtcgccgt ctgggccagg acggcagggc gcggacccgg ccacccgggc
    14101 ctgtacgacg gtggcctggc cggcaccctc gtcggcctgc ggctgggcgc ccggctccat
    14161 ccggcgctgc accgggcggc cgaccggctg cgcgaccacc tgaccggcga ggccgtcgcc
    14221 acggtctggc ggaccgcgga cgtcgccttc cccgactacg acctcatcac cgggcccgcc
    14281 ggcatcctgc tggccctgtg cgccggagcg gatccgaagg cgcccgaact ccaccggccc
    14341 gcccaccact tgacggccct ctgcgaccac gccgacctgt ggcgcctccg caccgggcag
    14401 tacgcggacc acccccacct gtcctggacg caaggccgcg tcaacaccgg cgtgggccac
    14461 ggcgtcgccg gcgtcgtcac cgcactgacc gcggctctgc gctacaccgg cgacccgggg
    14521 gcggcacagg cgctgcggca cgccacccgc tggctggcca cccggtccta cgtcgacgag
    14581 cgcggtgtcc gcacctggcc gggcgccggg ctcgacggcc cgcccccggc cggcgccaac
    14641 ccccgccagg cgtggtgcta cggaacgccg ggcgtcgcct gggcgctgtg ggacgcggcc
    14701 gacgcgctgg gcgaccggga ggcggccgac tgggcgctca cggcgttcgg cacgctcgcc
    14761 gagcggtacg acgagggctt ccacctgttc ggcgacggcc cggccgacct cctcgggctg
    14821 tgccacgggg cggcgggcgt actggccgtg gccgacgcct tcgaccgcca cgcccacctg
    14881 cccgccgcgg ccgccctcgg ctcccgtctc accgcgcacc tgcgggcccg gctccccgag
    14941 gcgctcggta cgccgtggcc gcccgggctc ctgaccggcg ccccgggcgc gctgagcgca
    15001 ctcctcaccg cccggggtgc cccgcgcgac tggctgccct gcctcggtct gcgctgacgg
    15061 cggacatccc gggcaccccg ccgacgaccc gcccaaaccc actcgttagg gtgaacggcc
    15121 atgagcgtaa agggttttga gggttacctg gcccgcctgg gcgtcaccga ccccggcgcg
    15181 ccctccgccg aggcgctgag cgcgctgcag cgggcgcatc tggaacgcgt tccgtacgag
    15241 aacatcgaca tccagctcgg caggccgccc ggcatcgaac cggagctgtc cgtacgccgg
    15301 ttcgccgccg ggcagggcgg ttactgcttc cacctgaacg gcggcttcgc cgcgctgctg
    15361 gaggccctcg gctacgacgt gacccgccat gtcgggggcg tccaccagga gcccgagggg
    15421 cgcggcgcca acggcaacca cctggcgctg accgtccgcg tcgacggcga ggcctggttc
    15481 gtcgacacgg ggctcgggga cgggccgtac gaaccgctgc cgctgcgccc gggcaggtac
    15541 cagcagggcc cgttcacgta ccgcatggag ccgtcggtca ccgagccggg cggctggacg
    15601 ctccacaacg gcccgcagag cgcgttcccg gtcatggagt tcgccgcccg gcccgtcacc
    15661 atggccgact tcgccgacga gcacctgcgg ctgtccaccg cgccggactc gccgttcctg
    15721 acgacgttcg ccgccctgcg ccgcgacgcc aagggcctgg acctgctgcg gggccgcgtc
    15781 ctcacccgca tcgacacggc cgggcgcacc gagcggccgc tggacacggc gggggagtgg
    15841 tacgccgcgc tcgcggacgt cttcggccgg aacctggacg gcctcgacgc cgacgaccgg
    15901 tccgccctgt gggagcgggt gacgcgcgcc cacgaggagt ggctggccgc gcgggcgacg
    15961 ccgtagccgt aatcagccgg tggcgtgggc ggcctccgcg aggtccgcga ccaggcgcgc
    16021 ggcgtcggcc cggaacaccg ccgagccggc cgccgcgcgc tcctcccgcg ccgggccggg
    16081 cccggccagt tcgccgaccg ccgccagcag tgcggggagg ccggaggcgt acacggtcag
    16141 gccctccgcc gccatctccc gcacccccac ggcgccgtgc ccggcgatgg gccggtggcc
    16201 gacgaccggg agcccggcgg cgagggcctg caccgccgtc tggcccgccg cgttgtcgat
    16261 cagggcccgc gccgacgcca tcagccccgg catgtcgtcc gtccagccga gcgcccggac
    16321 gcccggcagc cgggaggcgc gccggcgcag ccgctcgtca cgcccgcaca gcagcaccgg
    16381 gaggaaaccg tgccgggcga gcgccccggc ggtgtgcagc agcccggggc ccacgcccca
    16441 cgccccgccg gacagcagca ccaccggccg accgtccgcg tccgcgtccc ccgccccgcc
    16501 ggcgccccgc tcctgccgcc cggccgtgct cgtgctccgc gtgccgctcc cgtccggctg
    16561 cccgggcccc ggcgccccgg cttcccgcgc cccggcttcc ggcgccccgg cttcccgcgc
    16621 ctcggcttcc cgcgccccgg ccgccggcgc cccggctttc cgcgccccgg cttcccgcgc
    16681 cccggccgcc ggcgccccgg cttccggcgc ccggggcccc gcccccgctt cgtggaactc
    16741 gggcggcacg accggcccag tggcgattgc cgtccgcccc gtgccctccc gggccgcccg
    16801 ggcggcggtc tccgtgacgc acaggtacag gtcgttgccc gggtccagcc aggcgcggtg
    16861 cacggcgaag tcggtgacga acaccgcgca cggcacccgc agcacgcccc ggccgcgcat
    16921 ccggccggtg atctggcccg ccaggtggaa cgtggagacg atcacgtccg gccgccaccg
    16981 cgccacgagc gcgcccagcc gccgctcggc cagcgcggcc atcggcgaga cgtccagccc
    17041 ccggcgggga cgccccccgc gcgaacgcgg ccggggcgcc aggaacagcg cgtagatcgc
    17101 cgcgtacacc ggcggcaggc gtcgcaccac gaaccggtag aagccgcgca tcgccggtcc
    17161 cgtgccgggc ggcagcagcg tcagcacgtc ccgtacgagg acctcgtggc cgtccgcgcg
    17221 cagccggcgt gccagttcgc gggccaccgt gtcgtggccc gcgcccatgc tcgcgctgag
    17281 gaccaggcat cgccgcccca tgtggtgccc tccgtttccg tgccgttcca tcctgttccg
    17341 tccgggcgtc cggcgcggcc cgaggggtgg ccgacggcgg ccgaatcgga ctgttcgggt
    17401 ggatcggagg gcgcggtggc gggtggcgag aggcgaaccg gcgggaaacc gggaggctgg
    17461 aagggcacgg tcgacgacag tccggaggat ccaccatgcc ccctacgccc cgtcgcgagg
    17521 ccgcaccagg aagggcacgg tccacgggcg gcgaacccgt cgcgcggccg gtcgtgctcg
    17581 tcacgggcgc gtcctccggg atcggcgagg cgatcgccga ccggttcgcc gacgacggcc
    17641 gctgccggct gctgctcggc gggcgcgacg aggagcggct cgcggcggtg gcgcggcgga
    17701 cgggcggtgg cgcgctgcgg gcggacctgg ccgagcgggc gggggtggag cggctggcgg
    17761 ccgaggcgct ggagcgcgag ggccgggtcg acgtcctggt ggcggcggcg ggcatcggct
    17821 gggcggggcc gttcacccgg atgcccgccg acgccgtcga ccggctgatc gcggtcaacc
    17881 tcacctcggt cgtgcacctg gtgcggctgc tgctgccgcc gatggcggag cggggcgcgg
    17941 ggcacctggt gatgatcggt tccatggcgg ggcgcgtcgg ggtggccaat gaggcggtct
    18001 acgccaccac caagggcggc ctgctggcct tcgccgacag cctgcgctac gaactggccg
    18061 gtacccgcgt gggggtgacc gtcgtgctgc cgggggcggt ggacaccccg ttcttcacca
    18121 cccggggcgt cccgtaccac cgtgaccatc cgcgcccggt gccggccgaa cgggtggccg
    18181 aggtggtgtg gcgcgcggtc gcacggggcc gggacgacgt gttcgtaccg ggctggctcg
    18241 cgatgcccgc ccggatgcac ggagccgtcc ccggcttctt ccgcgccatg gccaagcggt
    18301 tcggctgagt ccggtgctgg cgctgtcgat ctgcctcgcg ctgctggccg ccctcggcaa
    18361 cgccggggcg tccgtgctcc agcggcaggg cgcggccgcc accggcccca ccccggcctc
    18421 ggcacggcgc ggctcgtgga tggcgggact ggtgcacagg cgggtgtggg tgtggggcgc
    18481 ggcgctgctg gccgtgtcgg gcatcctcca ggcgctggcc ctggcgaccg ggccgctgtc
    18541 cgtggtgcag ccggtgatga gtacggaact gatgttcacg ctggtggtcg gcggcgtggt
    18601 gttccggcgc cgcccggaca cccgcaccaa gtgggcgttc gccgccatgg ccctgggcct
    18661 ggccgtgttc ctggcgatgg ccgacccgac gggcggccgg tccacggtgc ccgtggcgga
    18721 ctgggtgtgg acggccctgg gcgcgggcgc cttcgtggcc ttcctgggcg tggtcgcgct
    18781 gcgcctgtcg ccggcgcccc gcgccgcggt gctcggcacg gccaccgcga ccgggttcgc
    18841 ctgcacggcg gcgctgctca aggacgcgct ggggcggctc ccggacggcg tcggcgcggt
    18901 gctcacgaca tggcagccgt acgccgcggt gggcgtgggg ctggcgagct tcgtgctgct
    18961 ccaggtgacg ctgcgggccg gcagcctggt ggcgtcgcag cccgcgctca ccctggggga
    19021 cgccctgctg agcgtggtgc tgggggtgac gctgttcgcg gaacgggtgc acctgggctg
    19081 gcgggtggtg ttcgaggcgc tggcgctcgc ggtcctggtg gccggctgtg tccagctggc
    19141 caggtccccg ctcgtcacgg acgaccccga gcgcccggag gaacgatggt gaactccctt
    19201 ccggcggccg ccctgggtgc cgtcgccgcc tggcacatcg ggcccgccgc gacctggctg
    19261 ccgggcgtgc gcgccgcgct gtggccgggc ctcgacgggc gcggcgatcc gtcgcacgtg
    19321 gcgctgacgt tcgacgacgg cccggacccc gacagcacgc ccgagttcct gcgcgccctg
    19381 gacgccctgt ccgtacgggc cacgttcttc gtgctgggca gccggctggc acgccgcccc
    19441 gccctgggtc ggctgatcgc ggcggagggc cacgaactgg ccgtccacgg ctggcagcac
    19501 gaccggccct ggtgcccccg tccgctgcgg gacacccggg acctggcgcg cacggcggac
    19561 ctggtcgccg acgcggccgg gcgtcggccg ctgtggtacc gccccgcgta cggcatcctc
    19621 accggcggcc ggtggaccgc cgcccgcgcc gccgggctgc gcacggtgct gtggtcggcc
    19681 tggggccgcg actggacggc cggggcgacg gcgcggagcg tgcacgccga agtgacgagg
    19741 acactgcggg gcggcgggac ggtgctgctg cacgactccg acgtggtgag cgcacccggg
    19801 gcgtggcggg ccgcgctggg cgcgctgccg gggctcgtcg cggagtgccg gtcccgcggt
    19861 ctggaggtcg ggccgctcag ggaccatgac gtgatcgaat agctcataca ttcgatttgc
    19921 tcgtacgctg aaggcatggc agcacacctg cagggctcgc tcttcgacca gaccgacgaa
    19981 atccgtctcg ggccgctgac cggcgtccgg cggaccgcgc tcggcgacgg cgcgtggatc
    20041 gacctgctcc ccggctggct gcacggagcc gacgccctgt tcgaggagct ggccgagggc
    20101 gtgccatggc gggccgagcg acgccagatg tacgaccacg aggtcgccgt accccgcctc
    20161 ctggccttct acggcgcagc ggacaccctg ccgcaccccg tgctcgacga ggcgcgcacc
    20221 gccctgtccg cgtactacgc cgccgaactg ggggagccgt tcaccacggc ggggctctgc
    20281 tactaccggg acggccggga cagcgtcgcc tggcacgggg accggatcgg gcgcggctca
    20341 cgcgaggaca ccatggtcgc gatcctgtcg gtcggcgagc cccgcgacct ggcgctgcgc
    20401 ccccgagggg gcggcccgtc gaggcgggtg ccgctcgggc acggcgacct gatcgtgatg
    20461 ggcggctcct gtcagcgcac ctgggagcac gccatcccca agaccaccaa gggcgccggc
    20521 ccccggatca gcatccagtt ccggccccgg ggcgtgggct gagcggccct ggtggacgtg
    20581 gtgcacgagc tggctgccca gctcgtaccg cgcccccacg atcgccagcc ggcgcgcctc
    20641 cacccgggcg gcgagatccg gttcggcggc cagcagggcg cgtacgtggc gtacgttcgc
    20701 ggtgatcgtc gcgtcgatcc gtgccgcccc ggtgtggctc cggtcgatga cgggccggat
    20761 ccgctcggcg atgtagtcga tgtgggcggg cggttcctca cccgtctcgt ccgccttcac
    20821 cgccgccgcc acggccccgc acgactggtg ccccagcacc acgacgagcg gtatgcccag
    20881 ctccagcacc ccgtacgcga tgctcccgag aaccgcctcg tccagcacct cgcccgccga
    20941 gcggaccgtc atcagatcgc ccaggccctg gtcgaatacc agctcgggcg ggacgcggga
    21001 gtcgacgcag cccaggatca gcgcgaaggg atgctgcccg gcgacggccg ccgtccggtc
    21061 ctccacgccc tcgtgcggat gcgcctggtg ccgggcgcgc cagcgcttgt tgccgtggac
    21121 cagctcgcgc cacgcctcca ccggggtacc ggggcgcgcg gagccggggc gcggtgccgc
    21181 gacggccggc gcgggggcga acccgagggc ggcggtgccg ccgagcgccg cacgcagcag
    21241 ggcgcggcgg ccgcgcgggg agggcagggc tgccggtccg tcacctggat gccatgtcac
    21301 gccccgaaac gtacgtccga ctgctcgccg ggtgttcgag tttgacctct gttggcccgc
    21361 ccatggccga cgtatggaca cgctttgggc gaacgatgga ttcctccgcc ggagcccccc
    21421 ccgccccgca cgcgccccgt ggtcgtccgg cgaccggcgg tcactcatgg tcgccatggg
    21481 gcgtgcggtg ttagaaaggg gaacgtggtc cacttcttcg accgattccg tggtgcctcg
    21541 gttcggtcac tggccgacag gcgcccacgg agcgtcgcgg gacaggtctt cgtcctgcag
    21601 gtggcgctgg tcgtgctgct ggtgctcggc gcggtcctgg ccctgctcct ccagtcgcgc
    21661 ggcgacagcg accgggaagc ccgcaaccgc tccatcgccg tcgccgaatc cttcgcccac
    21721 tccccgggcc tggagaacgt actgaagacc catcccgacc cgtcgagcgt gctccagccg
    21781 ctcaccgaaa cggcccgcgc gagggccggg gtcgacttca tcgtcgtgat ggacacccgc
    21841 ggcatccgct acacccaccc ccagcccgag cggatcggcg gacggttcgt cggcaccatc
    21901 gagccgtccc tggccggccg cgtccacacc gagagcgtcg acggcccgct cggcgaggag
    21961 gtccaggcca tcgtgcccgt gcggggctcc gacgggacgg tcatcggcct ggtctccgcc
    22021 ggactggagg tcaggaacgt caccggcgtc gtcaaccggc aactgcccgt catcctcgcc
    22081 accgccgccg ccggcctcgc cgtggccacc gccggatcgg ccctggtggc ccgccggctg
    22141 cgccgccaga cccacgggct cggccccgcc gagatgaccc gggtgtacga acaccacgac
    22201 gccgtcctgc actccgtacg cgagggcgtc gtcatcgtcg gcggcgacgg caggctcctg
    22261 ctcgccaacg acgaggccga acggctgctc cagctgcccc ccgacgccga gggccgcacc
    22321 gtcaaggacc tgccgggact cgaccgcggc atggccgagc tgctctgctc cggccgcgtc
    22381 gccaccgacg aggtcgtccc ggccggcgac cggctgctcg ccgtcaacca gcgccacacc
    22441 gaccggcacg gcggccccgc cgggaccgtc gccaccatcc gcgacaccac cgagctgcgc
    22501 tccctcaccg gccgcgccga gggcgcccgc aggcggctca acctgctgta cgacgccggc
    22561 gtcggcatcg gcaccacgct cgacgtcgtc cgcaccgccg aggaactcgc cgaggtcacc
    22621 gtccagcgct tcgccgactt cgtcaccgtc gacctcgccg accccgtcct gcgcggcgag
    22681 gagccctccg gcacggccgc cgacatgcgc cgcaccgccg tcgccggcat ccgcgacgac
    22741 caccccctct acccgcgcgg caagatgatc ggcttcgtcc cctccacgcc ccaggcacgc
    22801 ggctacggca gcggccgcgc ggaactggta cccgacctgt ccaaggcgcc cggctggcag
    22861 gcccaggacc ccgagcgggc ggcccggatc gtccagtacg gcatccactc cctcatcgcc
    22921 gtccccctca aggcccgggg cgtcgtcctc ggcgtcgcca acttctggcg ctccgagaag
    22981 cccgaaccct tcgaggacga ggacctcgcc ctcgccgagg aactcgtcgc ccgcgccgcc
    23041 gtctgcatcg acaacgcccg ccgctacacc cgcgaacacg ccatggccgt caccctccag
    23101 cgcagcctgc tgccccgcgc cctgcccgag cagagcgccc tggaggtggc ccaccgctac
    23161 ctgcccgccc agtcgggcgt cggcggcgac tggttcgacg tcatccccct gcccggcagc
    23221 cgcgtcgccc tcgtcgtcgg cgacgtcgtc gggcacgggc tgcacgccgc cgccaccatg
    23281 ggccggctgc gtaccgccgt acacaacttc tccaccctcg acctgccccc cgacgaactc
    23341 ctcggccgcc tcgacgacct cgtcggccgc atcgaccagg acgaggacga ggacgacacg
    23401 ggcgccgccg gaatgaccgg cgccacctgc ctgtacgcgg tgtacgaccc cgtctcccgg
    23461 cgctgctcca tggcccgcgc gggacacccg ctgcccgcgc tgatccaccc cgacggggac
    23521 gtcgagttcc ccgacctgcc ggccggacca ccgctcggcc tcggcggcat acccttcgag
    23581 accgccgaac tggacctggc cgagggcagc cagatcgtct tctacaccga cgggctgatc
    23641 gaggaccgca cccgcgacat cgacgtcggc atcgaactgc tccgcaaggc cctgggccgc
    23701 cccgccgcca cccccgagga ccgctgccaa ctggtcctcg acgagctcct gcccgcccac
    23761 cccaaggacg acgtggccct cctcgtcgcc cgcacccgcg cgctcgccgg cgaccgcgtc
    23821 gccgactggg acgtgccgtt ccaccccggc gccgtcggag gcatacgctc ggccgccgtg
    23881 cgcaagctca ccgagtgggg cctggacgac ctgtccttcg ccgccgagct gatcctcagc
    23941 gagctcatca ccaacgccat ccgctacggc gccgcccccg tccgcgtacg cctgctgtac
    24001 gaccgcggcc tgacctgcga ggtcgccgac aacaacagca cctcacccca cctgcggtac
    24061 gccgccacca ccgacgaggg cggccgcggc ctcttcctcg tcgcccagct ggccgaacgc
    24121 tggggaacgc gttacaccgc ccacggcaag gtgatctggg ccgaactccc gctccccggc
    24181 accggctcgt cctccggcga cggcaccggc accctgccgt tcgacgtctt caacgccggc
    24241 ctgatctgaa aggcgcccat gttcaccgcg cacggcccga ccctccgcga actcgccgcc
    24301 caggccctct cctccaccca gaccgggtac gacctgctgg cccccaagtt ccaccacacc
    24361 ccctaccgca cctccgacgg cgtgctgggc gcggtcgccg acgccctccg cccgctcgga
    24421 ccgttccgcg cgggcctcga cgtgtgctgc ggcaccggag ccggggtggg cgtgctgcgc
    24481 gagctgtgcc aggagagtgt gacaggcgtc gacttcagcg ccggcatgct cgaccaggcc
    24541 cgcgccgccc acgcggacgc gaacggcggt gcccccggcg tccactgggt acgcgccgac
    24601 gcccgcgccc tgccgttccg ctccgccttc gacctggccg tgagcttcgg cgcgttcggg
    24661 cacttcctcc ccgaggagcg gccccgcctg ttcgccggcg tgcaccgggc cctgcgaccc
    24721 ggcggccggt tcgtcttccc catccccgcc ccgcccccgg tcggctccct gccctactgg
    24781 gagctgtggg cgttcgacgc ggcgatgcgg gtgcgcaacc tgctgtggcg accgcgcttc
    24841 atcatgtact accgcaccct ccggctcacc gacgtcgtca cggagctgac ccgcaccggg
    24901 ttcacggtgg acctgacccc gctggaggag ttcggccggc ggcccgacgg ttcgccccgg
    24961 tgccggatgg tgaccgcgct gcgcacctga gccacctggg cgacggccgg ttgcggggca
    25021 cctgaactgc cggtcgagtg ggagaccggt ccgcgat
//
