LOCUS       NZ_LIYH01000003        22104 bp    DNA     linear   CON 28-MAR-2024
DEFINITION  Streptomyces sp. CB03234 scaffold3, whole genome shotgun sequence.
ACCESSION   NZ_LIYH01000003
VERSION     NZ_LIYH01000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CB03234
  ORGANISM  Streptomyces sp. CB03234
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 941528)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 941528)
  AUTHORS   Yan,X., Ge,H., Hindra,F., Yang,D., Huang,T., Crnovcic,I. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-SEP-2015) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2015
            Assembly Method                   :: CLC Genomics Workbench v. 7.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905885.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:52:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,127
            CDSs (total)                      :: 7,053
            Genes (coding)                    :: 6,894
            CDSs (with protein)               :: 6,894
            Genes (RNA)                       :: 74
            rRNAs                             :: 2, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 159
            CDSs (without protein)            :: 159
            Pseudo Genes (ambiguous residues) :: 0 of 159
            Pseudo Genes (frameshifted)       :: 70 of 159
            Pseudo Genes (incomplete)         :: 112 of 159
            Pseudo Genes (internal stop)      :: 10 of 159
            Pseudo Genes (multiple problems)  :: 33 of 159
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:29:50
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 45543
            Orig. end                         :: 67647
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LIYH01000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22104
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="1"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22104
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22104
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12104](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12104)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     misc_feature    309..323
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.49"
                     /tool="antismash"
     misc_feature    complement(314..327)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.17"
                     /tool="antismash"
     gene            443..2518
                     /locus_tag="AMK26_RS13365"
                     /old_locus_tag="AMK26_13195"
     CDS             443..2518
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016327774.1"
                     /locus_tag="AMK26_RS13365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_13195"
                     /product="NADH-ubiquinone oxidoreductase-F iron-sulfur
                     binding region domain-containing protein"
                     /protein_id="WP_073754841.1"
                     /transl_table=11
                     /translation="MDLRFGDSKPTDEERAAVDALLGPPASAWEGADDRTDADLRWARG
                     GRAARERRDQLLPGLHALNDRVGWISEGGLDYLCRRLTVPPAEAYGVATFYSLFAVRPR
                     PATVLHVCTDLACAARGAGALTAAVEDRLGPPGAASNGAVWQPSPCLGLCERAPAALLL
                     RAGEPPGGGPPREPGRAGAGAVGPGASLLAALSGEEPGTTEPAAPAGESPVSSAVAEGP
                     VPAEGRRPGIVAAATQSGGSRVSAAAANAGHASRPPTRAAAVVAPASADALVEAVRAPE
                     DAPAEPSARMAVPQAGQGGLSLLRRVGVVDPYSLDDYRAHGGYAALRRAFALGPAGVIR
                     EVTEAGLLGRGGAAFPTGRKWQATAAQPDHPHYLVCNADESEPGTFKDRVIMEGDPYAL
                     IEAMTIAGYAVGAHLGHLYIRGEYPRATERLENAIVRARERGLLGDDVLGQGYAFDIEI
                     RRGAGAYICGEETALFNSIEGYRGEPRSKPPFPVEKGLFGKPTAANNVETLVNVLPILM
                     GTAETKLFCVSGNVARPGVYELPFGATLGELLELAGRPDRMRAILLGGAAGGFVRPDEL
                     DIPLTFEGTRAAGTTLGSGVVLVLDDTVDLPGILLRIAEFFRDESCGQCVPCRVGTVRQ
                     EEALHRIKDRTGAAAATDIALLREVGQAMRDASICGLGQTAWNAVESAIDRLGAFE"
     gene            2515..3396
                     /locus_tag="AMK26_RS13370"
                     /old_locus_tag="AMK26_13200"
     CDS             2515..3396
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer2_4"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014055833.1"
                     /locus_tag="AMK26_RS13370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_13200"
                     /product="2Fe-2S iron-sulfur cluster-binding protein"
                     /protein_id="WP_073754842.1"
                     /sec_met_domain="Fer2_4 (E-value: 5.9e-23, bitscore: 76.4,
                     seeds: 114, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAVPLQLPRRLVEFTLDGEPVRVPEGSTVLDACRAAGKDVPTLC
                     HGDTLTPKNACRVCVVEVEGARTLAPACSRRAEPAMTVRTDTERARHSRKVVLELLASS
                     VDLSTTPHVATWLKEYEAKPDRFGPDAARLGEDPKIDNDLYVRDYDKCILCYKCVDACG
                     EQWQNSFAISVVGRGFDARIAVEHDAPLTDSACVYCGNCVEVCPTGALSFKSEFDMRAA
                     GTWDESRQTQTTTVCAYCGVGCNLTLHVQDNEIVKVTSPHDNPVTHGNLCIKGRFGYQH
                     VQNHVQNPRKRD"
     gene            3402..4250
                     /gene="fdhD"
                     /locus_tag="AMK26_RS13375"
                     /old_locus_tag="AMK26_13205"
     CDS             3402..4250
                     /GO_function="GO:0016783 - sulfurtransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="fdhD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003994171.1"
                     /locus_tag="AMK26_RS13375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_13205"
                     /product="formate dehydrogenase accessory sulfurtransferase
                     FdhD"
                     /protein_id="WP_073754843.1"
                     /transl_table=11
                     /translation="MGRVTERRRVIRIRDGAVSTRPDTLVAEEPLEIRLNGKPLAVTMR
                     TPGDDFALAAGFLVSEGVLGAAGDVRNIVYCAGAKEDGTNTYNVVDVQLAPGVAVPDIT
                     LERNVYTTSSCGLCGKASLDAVRTTARFPIADTPPVRVEPELLAALPDRLRAAQRVFDR
                     TGGLHAAALFSEDGELLDVREDVGRHNAVDKLVGRALREDLLPLDRAILLVSGRASFEL
                     AQKAVMAGIPVLAAVSAPSSLAVDLAAETGLTLVGFLRGRNMNVYAGEDRIALTAAASQ
                     G"
     gene            complement(4324..4713)
                     /locus_tag="AMK26_RS13380"
                     /old_locus_tag="AMK26_13210"
     CDS             complement(4324..4713)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010474544.1"
                     /locus_tag="AMK26_RS13380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_13210"
                     /product="hypothetical protein"
                     /protein_id="WP_073754844.1"
                     /transl_table=11
                     /translation="MNRTWIRPGATRPCSLVVCRGCCCGDARKRPGTDHAGQLARLREA
                     AAASGGRLAVRTSDCLGPCGQANVMVVQPSTEARRRGARAAWIGWALDDDCLDDILAWV
                     EAGGPGVAEPPDTLALQMIDPPKKT"
     misc_feature    complement(4757..4771)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.82"
                     /tool="antismash"
     gene            complement(4840..5856)
                     /locus_tag="AMK26_RS13385"
                     /old_locus_tag="AMK26_13215"
     CDS             complement(4840..5856)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015293 - symporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018513420.1"
                     /locus_tag="AMK26_RS13385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_13215"
                     /product="bile acid:sodium symporter family protein"
                     /protein_id="WP_073755481.1"
                     /transl_table=11
                     /translation="MSRRPLSWLPIDPYILALVATVALAALFPASGAAADAVGGVSTGA
                     IALLFFLYGARLSTREALDGLRHWRLHVTVLAATFVVFPLLGLAAKGLVPSVLTPALYG
                     GLLFLCLVPSTIQSSIAFTSIARGNVPAAICAGSFSSLAGIVLTPLLAALLLGGSAGGF
                     SADSLVKIVAQLLVPFLAGQVLRRWVGGFLTRHKKVLGYVDRGSILLVVYTAFSEGMVQ
                     GVWHQVTPARLAALLGVEAVLLAVMLALTWYGAGRLGFGREDRIAIQFAGSKKSLAAGL
                     PMASVLFGAHASLAVLPLMLFHQMQLMVCAVIAKRRANDPVPAQPAPGPRPAEPARR"
     misc_feature    complement(5943..5959)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 15.83"
                     /tool="antismash"
     misc_feature    5948..5962
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.76"
                     /tool="antismash"
     gene            5974..6843
                     /locus_tag="AMK26_RS13390"
                     /old_locus_tag="AMK26_13220"
     CDS             5974..6843
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012378319.1"
                     /locus_tag="AMK26_RS13390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_13220"
                     /product="LysR substrate-binding domain-containing protein"
                     /protein_id="WP_073754845.1"
                     /transl_table=11
                     /translation="MGSVYEPTQLRTFLAVAQTLSFTQAARRLGLRQSTVSQHVRRLEE
                     EAGRALFTRDTHSVELTEDGEAMLGFARTILAAHERAAAFFTGTRLRGRLRFGVSEDFV
                     LTRLPEILESFRREHPEVDLELTVGLSGTLHEKLAAGRLDLVLAKRRGGDTHGRLVWHS
                     TLTWIGAPRLRLDPDRPVPLIVFPPPGITRARALEALEAHGRPWRIVCTSSSLSGLIAA
                     ARAGLGVMAHTRGLIPPGLSPVPARAGLPELGAVDFVLLHGRPKGTAQEAADALAAAIL
                     AGGDRLHR"
     gene            7100..8899
                     /locus_tag="AMK26_RS13395"
                     /old_locus_tag="AMK26_13225"
     CDS             7100..8899
                     /NRPS_PKS="Domain: AMP-binding (14-469). E-value: 5.3e-94.
                     Score: 307.0. Matches aSDomain:
                     nrpspksdomains_AMK26_RS13395_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018100303.1"
                     /locus_tag="AMK26_RS13395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_13225"
                     /product="AMP-dependent synthetase/ligase"
                     /protein_id="WP_073754846.1"
                     /sec_met_domain="AMP-binding (E-value: 3.2e-89, bitscore:
                     294.9, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATAPLVGGLADSVFEHAVDDPDRVALGRKDADGQWVDVTAARFR
                     DEVLALAKGLLSDGVRFGDRVAIMARTRYEWTLFDFALWTVGAQSVPVYPTSSADQVHW
                     MLHDAEVTACVVEHEDHAMTVGSVVDRLPRLKRLWQLDAGAVAELVEAGARIDEEVVHR
                     HRRAVTPESIATIVYTSGTTGRPKGCVLTHANFMFEADTLVSRWEPVFHAKPGDEASTL
                     LFLPLAHVFGRMVEVAAVRKRVKFGHQPELTASALLADLAAFRPTFVLAVPYIFEKVYQ
                     AARRKAEAAGKAGPFDKAVEVAVRYAEALENKAFGLGPGPSAALRVQHQFFDKVVYGKV
                     RDALGGRVRHAMSGGSGMARRLGLFFEGAGVTVYEGYGLTESASAATANPPERTKYGTV
                     GPPIPGTTVHIADDGEVWLRGPHIFSGYLGDPAATAAVLHDGWLATGDLGKLDEDGYLT
                     ITGRKKEILVTSGGKSVSPAGLEERVRSHPLVAQCIAVGNDRPYIAALVTLDLEAVEHW
                     LAMQNRPPLPPAELVRDPSLETEIRRAVVAANTLVSQAESIRTFRILAHPFSEEHGLLT
                     PSLKLKRKAIEAAYAAEVEALYR"
     aSDomain        7142..8506
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMK26_RS13395_AMP-binding.1"
                     /evalue="5.30E-94"
                     /label="AMK26_RS13395_AMP-binding.1"
                     /locus_tag="AMK26_RS13395"
                     /protein_end="469"
                     /protein_start="14"
                     /score="307.0"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FEHAVDDPDRVALGRKDADGQWVDVTAARFRDEVLALAKGLLSDG
                     VRFGDRVAIMARTRYEWTLFDFALWTVGAQSVPVYPTSSADQVHWMLHDAEVTACVVEH
                     EDHAMTVGSVVDRLPRLKRLWQLDAGAVAELVEAGARIDEEVVHRHRRAVTPESIATIV
                     YTSGTTGRPKGCVLTHANFMFEADTLVSRWEPVFHAKPGDEASTLLFLPLAHVFGRMVE
                     VAAVRKRVKFGHQPELTASALLADLAAFRPTFVLAVPYIFEKVYQAARRKAEAAGKAGP
                     FDKAVEVAVRYAEALENKAFGLGPGPSAALRVQHQFFDKVVYGKVRDALGGRVRHAMSG
                     GSGMARRLGLFFEGAGVTVYEGYGLTESASAATANPPERTKYGTVGPPIPGTTVHIADD
                     GEVWLRGPHIFSGYLGDPAATAAVLHDGWLATGDLGKLDEDGYLTITGRKKEILVT"
     CDS_motif       7619..7678
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMK26_RS13395_0001"
                     /evalue="2.60E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="AMK26_RS13395"
                     /protein_end="193"
                     /protein_start="173"
                     /score="26.1"
                     /tool="antismash"
                     /translation="ATIVYTSGTTGRPKGCVLTH"
     CDS_motif       8339..8407
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMK26_RS13395_0002"
                     /evalue="1.50E-06"
                     /label="NRPS-A_a6"
                     /locus_tag="AMK26_RS13395"
                     /protein_end="436"
                     /protein_start="413"
                     /score="20.6"
                     /tool="antismash"
                     /translation="GEVWLRGPHIFSGYLGDPAATAA"
     gene            complement(8925..10004)
                     /locus_tag="AMK26_RS13400"
                     /old_locus_tag="AMK26_13230"
     CDS             complement(8925..10004)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712691.1"
                     /locus_tag="AMK26_RS13400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_13230"
                     /product="PQQ-dependent sugar dehydrogenase"
                     /protein_id="WP_073754847.1"
                     /transl_table=11
                     /translation="MTPTRRTLLAAALGAAALLTGLVPPSSAATAPASEPTGVTTLSTG
                     WTIPWGTAWLPDGSAALVTERDTFTVYKVTPSGTRTRVGTVPNSQTTGGEGGLMGVAVD
                     PGWATTRHVYFMHTSSEGNRIARMTYDGTTLTGYTTIVRGIRKARYHNGGRLAFGPDGY
                     LYASTGDAQVTSLAQDRNSLNGKILRMTKDGRPAPGNPFGTLVYSLGHRNPQGLAFDER
                     GRLWEAELGQNSRDELNLIKPGANYGWPACEGTCGVAGMTDPKKTWGVAEASPSGIAVA
                     DGAVYMASLRGQRLWRIPLDAGTEEVGTATAYYVGTYGRLRTVTTVPGAKHLWLSTTNA
                     DGNGGQPAGSDRILEVTIG"
     gene            complement(10001..11092)
                     /gene="pqqE"
                     /locus_tag="AMK26_RS13405"
                     /old_locus_tag="AMK26_13235"
     CDS             complement(10001..11092)
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003962383.1"
                     /locus_tag="AMK26_RS13405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_13235"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_073754848.1"
                     /sec_met_domain="PF04055 (E-value: 9.3e-21, bitscore: 70.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 4.2e-08, bitscore: 29.2,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 9.9e-11, bitscore:
                     37.5, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPPPPPPWALLAELTHGCPLRCAYCSNPLELVARSAELTAGEWA
                     GVFRQAAALGVVQTHLSGGEPLLRRDLDAIVAAADGAGIHTQLVTSGVGLTAQRLRGLV
                     AAGLRSVQLSVQHTDPAAAERIAGARAFTAKERAARLVREADLPLGVNVVLHRANLDAL
                     DDLVHLALTWGAERVELANTQFYGWALRNRAALLPDRAQVARAREAVARWRERLAGRLD
                     LVWVAPDYVDGTAKPCMGGWGAVSLTVHPDGTVLPCPAAAALPGLGAPNVKDHALDWIW
                     RESPAFTAYRGEEWMREPCRSCELRTSDFGGCRCQAYALTGDATRTDPACRKSPDHGLV
                     TALVDAAAVSTGSGYSYRTEGPR"
     gene            complement(11089..11418)
                     /gene="pqqD"
                     /locus_tag="AMK26_RS13410"
                     /old_locus_tag="AMK26_13240"
     CDS             complement(11089..11418)
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014174693.1"
                     /locus_tag="AMK26_RS13410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_13240"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_079277577.1"
                     /sec_met_domain="PqqD_RRE (E-value: 2.3e-17, bitscore:
                     58.1, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 7.4e-09, bitscore: 31.4,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSADSGLSADSGSGLSAGSGPGGGSGTWRPALHRSVMLRHDHVRG
                     TDLLVLPERVVVLHGNAGSVLRLCDGARDVDGIVAALQARHPGAPVAEEVPDFLGRLRA
                     EGWLT"
     aSDomain        complement(11092..11340)
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_AMK26_RS13410_PqqD_RRE.1"
                     /evalue="8.20E-19"
                     /identifier="RREFam006.1"
                     /label="AMK26_RS13410"
                     /locus_tag="AMK26_RS13410"
                     /protein_end="109"
                     /protein_start="26"
                     /score="58.1"
                     /tool="antismash"
                     /translation="TWRPALHRSVMLRHDHVRGTDLLVLPERVVVLHGNAGSVLRLCDG
                     ARDVDGIVAALQARHPGAPVAEEVPDFLGRLRAEGWLT"
     gene            complement(11415..12104)
                     /gene="pqqC"
                     /locus_tag="AMK26_RS13415"
                     /old_locus_tag="AMK26_13245"
     CDS             complement(11415..12104)
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645345.1"
                     /locus_tag="AMK26_RS13415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_13245"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_073754849.1"
                     /sec_met_domain="TIGR02111 (E-value: 3.3e-88, bitscore:
                     290.6, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTWSREEFTARLRAVATDRYHDRHPFNVRMHDGTLTPAELRRWI
                     LNRFHYQRHIPVKDALVLAKLDTPALRRAWLRRIQDHDGEKDGQGGIERWLRLGEAAGI
                     DRARLTSGDGVLPGVRLAVDGYVNFCRLRPRLEAVAASLTELSAPTLMRTRIEAFETHY
                     PWIDADGLAYFRDRIGQGGRDSAEALTLVLDWARTREEQERAVAALAFKCDVLWSLLDA
                     VEAGGRS"
     gene            complement(12101..12997)
                     /gene="pqqB"
                     /locus_tag="AMK26_RS13420"
                     /old_locus_tag="AMK26_13250"
     CDS             complement(12101..12997)
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003962380.1"
                     /locus_tag="AMK26_RS13420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_13250"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_073754850.1"
                     /transl_table=11
                     /translation="MLLQVLGTAAGGGLPQWNCACPGCAGARAHPERRRRHASLALRAD
                     EGCWYVVNATPDLGEQIEAARELWPGPGPRDTPLAGVVLTDAELDHTLGIARLREADGF
                     EILATPPVRTALLDHLRLGDTLAPYTRIEWRELSTKPQPLTAGGTIEIDAVPVSAKRPR
                     YATDNGPDDPTWVVALRLRDTTTGGTLLYAPALAAWTEEFQYAAEDADCVIVDGTFWDD
                     DEPVRSGFSTRSATAMGHLPIDGPGGTAHRLAALPARCLYTHLNNTNPLADPHAPQHAL
                     LAARGLHVAADRMVIEL"
     gene            complement(13009..13140)
                     /gene="pqqA"
                     /locus_tag="AMK26_RS13425"
     CDS             complement(13009..13140)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_023537811.1"
                     /locus_tag="AMK26_RS13425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_073754851.1"
                     /transl_table=11
                     /translation="MQESFASHENAEERAAASVLWQTPEYTVVETALEVTAYFLADR"
     gene            13347..14180
                     /locus_tag="AMK26_RS13430"
                     /old_locus_tag="AMK26_13255"
     CDS             13347..14180
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018848470.1"
                     /locus_tag="AMK26_RS13430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_13255"
                     /product="aldo/keto reductase"
                     /protein_id="WP_073754852.1"
                     /transl_table=11
                     /translation="MSKVPSLTLHNGVSMPQLGFGVWQVPDDEAAKAVGTALEAGYRSI
                     DTAAIYENEKGTGEAIAASGIARDELFVTTKLWNSEQGHDSTLRAFDASLAKLGLDYVD
                     LYLIHWPLPSKDLYVDTYKALEKIYADGRARAIGVSNFLPEHLERLLGETSVVPALNQI
                     ELHPQLQQAESRAFHARHGILTEAWSPLGQGKGLLEVPTIVAVARKHGRTPAQVVLRWH
                     LQLGTVVIPKSVTPSRIRENIDVFDFELDADDLAALAALDEGKRLGPDPATFDYS"
     gene            complement(14277..14747)
                     /locus_tag="AMK26_RS13435"
                     /old_locus_tag="AMK26_13260"
     CDS             complement(14277..14747)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006374162.1"
                     /locus_tag="AMK26_RS13435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_13260"
                     /product="hypothetical protein"
                     /protein_id="WP_073754853.1"
                     /transl_table=11
                     /translation="MQREDIPGPGESGLSTEDIAQPGGAGEATGERPDAPAFPMESTAE
                     PAGSAPPTAPEVAVPAEHDEDETPRLLAEEDEEDFRTRWQDVQTQFVDDPREAVHKADA
                     LVADVMRQLASTFADHKKDLEGQWNRGEDVDTEDLRKALRQYRSFFNRLLTT"
     gene            complement(14778..15335)
                     /locus_tag="AMK26_RS13440"
                     /old_locus_tag="AMK26_13265"
     CDS             complement(14778..15335)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018540661.1"
                     /locus_tag="AMK26_RS13440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_13265"
                     /product="hypothetical protein"
                     /protein_id="WP_073754854.1"
                     /transl_table=11
                     /translation="MSTGTLLAIIIPVAVILAALAVVAFLGFRSRRLRERFGPEYERTV
                     EDTGSRLAAERDLSAREKRHDELDIRPLPGEARDRYTRDWADVQGEFVDRPEDAVQDAD
                     LLVTSLMRERGYPTEDLDQRLKDLSVEHGRTIEHYRAAHEVNRLSMKHQATTEQLRGAM
                     VHYRALFDELLSDGGQSHRAPA"
     misc_feature    15297..15312
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.24"
                     /tool="antismash"
     misc_feature    complement(15423..15437)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.95"
                     /tool="antismash"
     misc_feature    complement(15423..15438)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.58"
                     /tool="antismash"
     misc_feature    15424..15437
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.07"
                     /tool="antismash"
     misc_feature    complement(15424..15439)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.45"
                     /tool="antismash"
     misc_feature    15427..15442
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.93"
                     /tool="antismash"
     gene            15466..16452
                     /locus_tag="AMK26_RS13445"
                     /old_locus_tag="AMK26_13270"
     CDS             15466..16452
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009719238.1"
                     /locus_tag="AMK26_RS13445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_13270"
                     /product="permease"
                     /protein_id="WP_073754855.1"
                     /transl_table=11
                     /translation="MNPAAPARERAPGAIPPSVAVTGAVSLLLIAALALPVLNHPGFRA
                     WQTICVALTVQALPFLLFGTVVSGAVNAFVPARVFSRALPRNPALAVPVAGAAGVVLPG
                     CECASVPVAGSLIRRGVTPAAAFAFLLSAPAVNPVVLVSTAVAFPGQPGMVAARLVASL
                     ATAATMGWLWLKWGRAEWLKMPARHTGHRAGHSRWEEFRVGFQHDFLHAGGFLVVGAMA
                     AATFNVLVPRSVLDVFADSPWLSVLFLAALAIVLAVCSEADAFVAASLTGFSPTARLTF
                     MVVGPMVDVKLIALQAGTFGRAFAVRFSAATAVVAVACACLTAWWLL"
     gene            16449..17213
                     /locus_tag="AMK26_RS13450"
                     /old_locus_tag="AMK26_13275"
     CDS             16449..17213
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017945051.1"
                     /locus_tag="AMK26_RS13450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_13275"
                     /product="TIGR03943 family protein"
                     /protein_id="WP_073754856.1"
                     /transl_table=11
                     /translation="MRRHIQAALLLLTGSAVLHISLLSQVYLRYVKEGLRPFLIASAVL
                     LLALGLISAVRDGLPFAPRRPDDEPLDDGHGHGHGDGGPRVAWVLFLPVLALLLYAPPA
                     LGSYTAARETDNLIAPVSEFRPLPDADPAPLALSGFIARVQQDRDRSLAGRTVLMTGFV
                     TPANPRAKDGTWYLTRLVVSCCAADSQSLRIRVYGRPAPSADTWVTVTGTWHPGGGGEL
                     GTATAAVALDARTVERVPEPVSPYQDTPPPPP"
     gene            complement(17263..18144)
                     /locus_tag="AMK26_RS13455"
                     /old_locus_tag="AMK26_13280"
     CDS             complement(17263..18144)
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (48-154). E-value: 1.1e-14. Score:
                     45.3. Matches aSDomain: nrpspksdomains_AMK26_RS13455_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019890514.1"
                     /locus_tag="AMK26_RS13455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_13280"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_073754857.1"
                     /sec_met_domain="PCMT (E-value: 2.3e-06, bitscore: 23.1,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRHHHGHHDHDDTHMDWNEMLPLLEQGAELQGPLYRQAAAWLGE
                     LAPAAGVRRILDIGSGPGVLSCLLAEAFPYAEVVAVDATPELLERTRERARAASLGDRV
                     TTHHADLPGGIAGLGRADLIWAADSLHHLGDQRGAVAELAGRLRPGGLLAVVEGGLPTR
                     RLPHNFGIGRPGLEARIDAVHADWFAEMRAGLPGAKEDVDDWRALLSGAGLVPSGTRTF
                     LHDMPAPVTDAVRQQIVTVFARYRDGLGERLAPEDVATLDRLLDPADPQSLHHRPDVFL
                     LTARTVHTARRG"
     aSDomain        complement(17683..18000)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMK26_RS13455_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="1.10E-14"
                     /label="AMK26_RS13455_oMT.1"
                     /locus_tag="AMK26_RS13455"
                     /protein_end="154"
                     /protein_start="48"
                     /score="45.3"
                     /tool="antismash"
                     /translation="AAGVRRILDIGSGPGVLSCLLAEAFPYAEVVAVDATPELLERTRE
                     RARAASLGDRVTTHHADLPGGIAGLGRADLIWAADSLHHLGDQRGAVAELAGRLRPGGL
                     LA"
     gene            complement(18171..>18770)
                     /locus_tag="AMK26_RS13460"
                     /old_locus_tag="AMK26_13285"
                     /pseudo=""
     CDS             complement(18171..>18770)
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018513427.1"
                     /locus_tag="AMK26_RS13460"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_13285"
                     /product="AraC family transcriptional regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="VGTYRMDSEVGRRLLDALPPLLHLTAEQGNCPVMPVREEEIGRDE
                     PGQSVVLDRILDLLLIAALRAWFSRPEAAAPGWYRAMGDPVVGAALRLMQNDPARPWTV
                     ASLAAEAGVSRAGLARRFTDLVGEPPMTYLTGWRLALAADLLRTTDATVESVARQVGYS
                     GSFALSAAFKRVRGVGPREHRARRRHLLPKQQQSSP"
     misc_feature    18984..18998
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.02"
                     /tool="antismash"
     gene            complement(19037..20008)
                     /locus_tag="AMK26_RS13465"
                     /old_locus_tag="AMK26_13290"
     CDS             complement(19037..20008)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010045980.1"
                     /locus_tag="AMK26_RS13465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_13290"
                     /product="YafY family protein"
                     /protein_id="WP_073754858.1"
                     /transl_table=11
                     /translation="MKSSRLLSILLLLQTRGRMTAAQLAAELEVSVRTVYRDVEALHTA
                     GVPLYGDAGHRGGYELLAGFRTRLTGLSAGEAEALFLTALPGPAADLGLGPALAGARLK
                     LRAALPPGLRAQADRMSRRFHLDAPGWYAEDDAVPFLPAVAEAVWRGRVLAVRYRRWTE
                     PTDVGRRLEPYGLVLKAGRWYVVAARPGGSGPRTYRVDQILELTVTGEEFDVPDDFDLS
                     AYWQAHQRDFHARLHRGEALVRLSPRGVARLTGAAARAAATTGTDEPDGWTRAVLPVES
                     PDHAHDQFLALGTDVEVLAPDELRTRLAETARAVAERYAAGA"
     gene            20048..20530
                     /locus_tag="AMK26_RS13470"
                     /old_locus_tag="AMK26_13295"
     CDS             20048..20530
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431675.1"
                     /locus_tag="AMK26_RS13470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_13295"
                     /product="hypothetical protein"
                     /protein_id="WP_073754859.1"
                     /transl_table=11
                     /translation="MPFAEKYLFVPPPVEAGGRRVKRYHVTADPSGIAPDVEKAAYALL
                     PGLLPEPDGTPPASFSVLHRGGDDGAYLNTYTWVWDNVLHCAIAVAGQPSLGCPDRDPT
                     HFVRLDKPWIGCVWELPPLAHERDAWVRHMLAPDRPDLDAYMADSLPEGTTGGTRA"
     gene            20527..20988
                     /locus_tag="AMK26_RS13475"
                     /old_locus_tag="AMK26_13300"
     CDS             20527..20988
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015656666.1"
                     /locus_tag="AMK26_RS13475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_13300"
                     /product="hypothetical protein"
                     /protein_id="WP_241837886.1"
                     /transl_table=11
                     /translation="MNGFDFLEGRWNVHNRMLADFLDPGSGWEEFDGHTTGHLHWSGAA
                     HVDEVVFPSKGFCGLTVRLYEPETGEWTLNWADSRTGRLEPPVRGRFDADGTGRFHGDD
                     HYAGRAVRVRFLWSGITATTARWEQAFSVDGEETEETWVTNRVMTFTRA"
     gene            complement(20993..21298)
                     /locus_tag="AMK26_RS13480"
                     /old_locus_tag="AMK26_13305"
     CDS             complement(20993..21298)
                     /EC_number="4.2.1.96"
                     /GO_function="GO:0008124 -
                     4-alpha-hydroxytetrahydrobiopterin dehydratase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006729 - tetrahydrobiopterin biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009343812.1"
                     /locus_tag="AMK26_RS13480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK26_13305"
                     /product="4a-hydroxytetrahydrobiopterin dehydratase"
                     /protein_id="WP_073754860.1"
                     /transl_table=11
                     /translation="MPTEPLSQKEIEDRLRELPGWSQEGDRIARTYRLGTHFAATAMVV
                     HVARIQEELNHHSDLTLGYNTVNLTVNTHDAGGAITEKDFSLAARVEEIAPVHGAN"
ORIGIN
        1 gtgggaggcg gacccggcgc ggcgcggtag gccggcgccc ttcgggatcg tgcggcacga
       61 cccgcccgtc gacctgacgg acgaccggta cccgatccgg ctgacgacgg gccggcgcct
      121 cgactcgtac aacacgggcg tgcagagcgg cagtttcgcc tcgccgctgc ggcgcgggga
      181 gtacgtcgag ctgtgccccg aggacgcgga gcggtacggg gtcgtggtcg gcgaggaggt
      241 gctggtgacg tcccggcggg gggcggtgac ggcgccggtg tgggtggacc cggcgctgcg
      301 gccgggcctg gcattcatga ccatgcactt tccggacgag gtggacacca accagctgac
      361 gatcgaggcg aactgcccga tcgcggggac ggcggagttc aaggcgtccg cgatccgcat
      421 cgagaagagg agctgatcgg gcgtggacct gcgcttcggt gacagcaagc cgaccgacga
      481 ggaacgggcg gcggtggacg cgctgctggg gccgccggcc tcggcctggg agggcgccga
      541 cgaccgcacg gacgcggacc tgcgctgggc gcgcggcggc cgcgcggccc gcgagcggcg
      601 cgaccagctg ttgccggggc tgcacgcgct gaacgaccgg gtcggctgga tcagcgaggg
      661 cgggctcgac tacctgtgcc gacggctgac ggtgccgccg gcggaggcgt acggggtggc
      721 cacgttctac tcgctgttcg cggtacggcc gcgccccgcg acggtgctcc acgtctgtac
      781 ggacctggcg tgcgcggccc gcggcgcggg cgccctgacg gcggcggtcg aggaccggct
      841 cggcccgccg ggcgccgcgt cgaacggcgc ggtgtggcag ccgagcccct gcctgggcct
      901 gtgcgaacgc gccccggcgg cgctgctgct gcgggcgggc gaaccgcccg ggggcggccc
      961 gccccgggag cccggccgag cgggtgccgg ggcggtgggt ccgggagcct cgctccttgc
     1021 cgcgttgagc ggtgaggaac ccggtacgac ggagcccgcg gctcccgccg gtgagtcccc
     1081 cgtgagcagc gccgtggcgg aagggccggt cccggccgag gggcggcggc ccgggatcgt
     1141 ggcggccgcc acccagagcg gcgggtcccg ggtcagtgcc gccgcggcga acgccggcca
     1201 cgcgtcccgg ccgccgacgc gggccgccgc cgtcgtggcg cccgcctccg cggacgcgct
     1261 cgtggaggcg gtgcgggcgc cggaggacgc gcccgccgag cccagcgcgc ggatggcggt
     1321 gcctcaggcc gggcagggcg gcctgtcgtt gttgcggcgc gtcggggtcg tcgatccgta
     1381 cagcctggac gactaccggg cgcacggcgg gtacgccgcg ctgcgccggg cgttcgcgct
     1441 cgggcccgcc ggggtcatcc gggaggtgac cgaggccggg ctcctcgggc gcggcggggc
     1501 ggcgttcccg acggggcgca agtggcaggc gaccgccgcc cagcccgacc acccgcacta
     1561 tctcgtgtgc aacgccgacg agtcggagcc gggcaccttc aaggaccggg tgatcatgga
     1621 gggtgacccg tacgcgctga tcgaggccat gaccatcgcc gggtacgcgg tcggcgccca
     1681 cctcggacac ctctacatcc ggggggagta cccgagggcc acggagcggc tggagaacgc
     1741 gatcgtacgg gcccgggagc gcgggctcct gggtgacgac gtcctcgggc agggctacgc
     1801 cttcgacatc gagatccggc gcggcgccgg ggcgtacatc tgcggcgagg agacggccct
     1861 cttcaactcc atcgagggct accgcggcga accccgctcc aagccgccct tccccgtgga
     1921 gaagggcctg ttcggcaagc cgaccgccgc caacaacgtc gagacgctgg tcaatgtcct
     1981 gccgatcctc atggggacag cggagacgaa gctgttctgc gtgtcgggga acgtggcgcg
     2041 gcccggcgtg tacgagctgc cgttcggcgc caccctcggc gagctgctgg agctggcggg
     2101 ccggccggac cggatgcggg ccatcctgct cggcggggcg gcgggcgggt tcgtacgccc
     2161 cgacgagctg gacatcccgc tcaccttcga gggcacgcgc gccgccggga ccaccctcgg
     2221 ctcgggcgtg gtcctcgtcc tggacgacac cgtcgacctg cccggcatcc tcctccgtat
     2281 cgccgagttc ttccgggacg agtcgtgcgg ccagtgcgtg ccgtgccggg tcggcaccgt
     2341 ccggcaggag gaggcgctgc accgtatcaa ggaccgtacc ggcgccgcgg ccgccaccga
     2401 catcgccctg ctgcgcgagg tcggccaggc catgcgcgac gcctcgatct gcggactggg
     2461 gcagaccgcg tggaacgccg tcgagtccgc catcgaccgt ctgggggcct tcgaatgacc
     2521 gccgtaccgc tgcaactccc gcgccgcctc gtcgagttca ccctcgacgg cgaacccgtc
     2581 cgcgtccccg agggctccac cgtcctggac gcctgccggg ccgccgggaa ggacgtcccg
     2641 accctgtgcc acggcgacac gctcacgccc aagaacgcct gccgcgtctg cgtcgtcgag
     2701 gtggagggcg cccgcacgct cgcccccgcc tgctcgcgcc gcgccgagcc ggccatgacc
     2761 gtccgcacgg acacggaacg ggcccggcac agccggaagg tggtgctgga gctgctcgcc
     2821 tcgtccgtcg acctgtcgac caccccgcac gtcgcgacgt ggctcaagga gtacgaggcg
     2881 aagccggacc gtttcggccc ggacgcggcc cgcctgggcg aggacccgaa gatcgacaac
     2941 gacctgtatg tccgcgacta cgacaagtgc atcctgtgct acaagtgcgt cgacgcgtgc
     3001 ggcgagcagt ggcagaactc cttcgccatc tccgtcgtcg gccgtggctt cgacgcccgg
     3061 atcgccgtcg agcacgacgc cccgctcacc gactccgcgt gcgtgtactg cggcaactgc
     3121 gtcgaggtgt gcccgacggg cgcgctcagc ttcaagagcg agttcgacat gcgggcggcc
     3181 ggtacgtggg acgagtcgcg ccagacgcag accacgacgg tctgcgcgta ctgcggagtc
     3241 ggctgcaacc tcaccctgca cgtgcaggac aatgagatcg tcaaggtcac ctcgccgcac
     3301 gacaacccgg tgacccacgg caacctctgc atcaagggcc gtttcggcta ccagcacgta
     3361 cagaaccacg tacagaaccc tcggaagcgg gactgatcag catgggacgg gtcaccgagc
     3421 gccgccgcgt catccgcatc cgggacggag ccgtctcgac ccgtcccgac accctggtgg
     3481 ccgaggagcc gctggagatc cggctcaatg gcaagccgct cgccgtcacc atgcgtacgc
     3541 cgggtgacga cttcgcgctg gcggccggtt tcctcgtcag cgagggggtg ctgggcgccg
     3601 ccggcgacgt acggaacatc gtgtactgcg ccggggccaa ggaggacggg accaacacgt
     3661 acaacgtggt ggacgtgcag ctcgcgcccg gcgtggccgt cccggacatc acgctggaac
     3721 ggaacgtcta caccacgtcc tcgtgcggcc tgtgcgggaa ggcgagcctg gacgccgtac
     3781 gcaccaccgc ccgcttcccg atcgccgaca ctcccccggt ccgcgtcgag ccggagctgc
     3841 tcgccgcgct ccccgaccgg ctgcgggcgg cgcagcgggt cttcgaccgg accggcgggc
     3901 tgcacgcggc cgcgctgttc tcggaggacg gcgagctgct ggacgtacgg gaggacgtcg
     3961 gccggcacaa cgcggtggac aagctggtcg gccgggcgct gcgggaggac ctgctgccgc
     4021 tggaccgggc gatcctgctg gtgtcggggc gggcgtcgtt cgagctggcg cagaaggcgg
     4081 tgatggcggg gatcccggtg ctggcggcgg tgtcggcgcc gtcgtcgctc gccgtggacc
     4141 tggccgccga gacgggcctg acgctggtcg gcttcctgcg cggccggaac atgaacgtgt
     4201 acgcgggtga ggaccggatc gccctgacgg ccgcggcctc ccagggctga cgcccggccc
     4261 cgcccggtgc acgggccggg ccggccggcg gggtgcgccc cctgcgccgg ccggttccgc
     4321 gccctatgtc ttcttcggcg ggtcgatcat ctgcagggcg agcgtgtccg ggggctccgc
     4381 gacgccgggg ccgcccgcct ccacccacgc caggatgtcg tcgaggcagt cgtcgtcgag
     4441 cgcccagccg atccacgcgg cccgtgcacc gcgccgccgg gcctctgtcg acggctggac
     4501 gaccatgacg ttggcctggc cgcacggccc gaggcagtcg ctggtgcgga cggcgagccg
     4561 cccgccggac gccgccgcgg cctcgcgcag ccgggccagc tgaccggcgt ggtcggtgcc
     4621 ggggcgttta cgggcgtcgc cgcaacagca gccgcggcac acgaccaggg agcaggggcg
     4681 ggtggcgccg gggcgtatcc aggtgcggtt caccgggcgg cgtccggggc gtcggatgag
     4741 ggcatgacct cacggtatcg acctgggtga tcatcccggg acggtggggt gcgcgatccg
     4801 ctcctgcagg gccacgaacc ggtttgcgtt cggcgggcgt cagcggcggg cgggctctgc
     4861 cgggcgcggg ccgggcgccg gctgtgccgg aaccgggtcg ttcgcgcggc gcttcgcgat
     4921 gaccgcgcag accatcagct gcatctggtg gaacagcatc agcggcagca cggcgagcga
     4981 ggcgtgcgcg ccgaacagca cgctcgccat gggaaggccc gccgccaggc tcttcttgga
     5041 cccggcgaac tggatcgcga tccggtcctc ccggccgaac cccagccgcc ccgctccgta
     5101 ccaggtgagc gccagcatca cggcgagcaa caccgcctcg acgcccagca gggccgccag
     5161 ccgggccggc gtcacctggt gccagacgcc ctggaccatg ccctcgctga acgccgtgta
     5221 gaccacgagc aggatcgagc cccggtcgac gtaccccagt accttcttgt gccgggtcag
     5281 gaaccctccc acccagcggc gcagcacctg ccccgccagg aacggcacca gcagctgcgc
     5341 gacgatcttc accagcgagt cggccgagaa gccacctgcg ctgccgccca gcagcagcgc
     5401 cgccagcagc ggcgtcagga cgatccccgc cagcgacgag aaggagcccg cgcagatcgc
     5461 ggcgggcacg ttgccgcgcg cgatcgacgt gaaggcgatc gacgactgga tggtggacgg
     5521 caccaggcac aggaacagca gcccgccgta cagggcgggc gtcagcacgg acggcaccag
     5581 gcccttcgcc gccagcccca gcaacgggaa gaccacgaac gtcgccgcca gcacggtcac
     5641 atggaggcgc cagtgccgca gcccgtccag cgcctcccgg gtggacagcc gcgccccgta
     5701 caggaagaac agcagggcga tcgcgccggt cgacaccccg ccgaccgcgt cggcggccgc
     5761 gccggaggcc gggaacagtg ccgcgagggc caccgtcgcg accagcgcca ggatgtacgg
     5821 gtcgatcggc agccaggaca ggggtcggcg gctcatgtgc tccacgtgct ctcgggttcg
     5881 ggtcgtgccc tctccatcgt ccacgtgatc gcgccgatcg ggaatcccgt acaccgctct
     5941 gactgtcatc atgttccacg atgaccgcct agtctgggga gcgtgtacga gcccactcag
     6001 ctgcgcacct tcctggccgt ggcgcagacc ctgagcttca cccaggccgc gcgccgcctc
     6061 gggctgcgcc agtcgacggt cagccagcac gtgcggcggc tggaggagga ggcggggcgt
     6121 gccctgttca cccgggacac gcacagcgtg gagctgacgg aggacggcga ggccatgctc
     6181 ggcttcgccc ggacgatcct ggcggcgcac gagcgggcgg cggcgttctt caccggtacg
     6241 cggctgcgcg ggcggctgcg gttcggggtg tcggaggact tcgtgctgac ccggctgccc
     6301 gagatcctgg agtcgttccg gcgcgagcac cccgaggtgg acctggagct gacggtcggc
     6361 ctgtccggca cgctgcacga gaagctggcg gccgggcggc tggacctggt gctcgccaag
     6421 cggcgcggcg gcgacaccca cggccggctg gtctggcact ccaccctgac gtggatcggc
     6481 gcgccccggc tgcggctgga cccggaccgc ccggttccgc tgatcgtctt cccgccgccg
     6541 ggcatcaccc gggcccgcgc tctggaggcg ctggaggcgc acggccgccc gtggcggatc
     6601 gtctgtacga gttcgagcct gagcggcctg atcgcggccg cccgcgcggg cctcggcgtg
     6661 atggcccaca cccgtggcct gatcccgccg ggcctgagcc ctgtgccggc ccgggcgggc
     6721 ctgccggaac tgggcgccgt ggacttcgtc ctcctccacg gccgccccaa gggcaccgcc
     6781 caggaggcgg cggacgccct ggcggcggcc atcctggcgg gcggcgaccg gctgcaccgg
     6841 tagccgcccc cggtgatccc gcgtgagcgc ggcgtacaga ttccgtggag attccgccac
     6901 ccactactta cccggcggtc agtagcgtgc gtgtccccac gcccgtggct gggcacttag
     6961 cttctgacct gtggcgatgt cgcacggacg gggttggcga aggccctccc gcgcgggtcc
     7021 ggcgtggggt accgtcaccc accgccgtgc ggagcacccc ccaaggagca ggccattgcg
     7081 cgagttcact gtccccccca tggcgacggc tcccctggtc ggcggactgg ccgattccgt
     7141 attcgagcac gccgtggacg atccggaccg tgtggcgctg gggcgcaagg acgcggacgg
     7201 gcagtgggtc gatgtgacgg cggcgcggtt ccgggacgag gtgctggcgc tcgccaaggg
     7261 gctgctctcg gacggcgtac ggttcggcga ccgggtcgcc atcatggcgc gtacgcgcta
     7321 cgagtggacg ctgttcgact tcgcgttgtg gacggtcggt gcgcagtccg tgcccgtcta
     7381 ccccacctcc tccgccgacc aggtccactg gatgctccac gacgccgagg tgacggcgtg
     7441 cgtggtggag cacgaggacc acgccatgac cgtcggctcg gtggtcgacc ggctcccccg
     7501 gctgaagcgg ctgtggcagc tggacgccgg ggcggtcgcc gagctggtgg aggcgggcgc
     7561 ccgcatcgac gaggaagtgg tgcaccggca ccggcgcgcg gtgacgcccg agtcgatcgc
     7621 cacgatcgtc tacacgtccg ggacgacggg ccgccccaag gggtgcgtcc tgacgcacgc
     7681 caacttcatg ttcgaggcgg acaccctggt cagccgctgg gagccggtgt tccacgccaa
     7741 gcccggcgac gaggcgtcga cgctgctgtt cctgccgctc gcgcatgtct tcgggcggat
     7801 ggtggaggtc gcggcggtcc gcaagcgcgt gaagttcggc catcagccgg agctgacggc
     7861 gagcgcgctg ctggccgacc tggcggcgtt ccggccgacg ttcgtgctgg ccgtcccgta
     7921 catcttcgag aaggtctacc aggcggcgcg ccgcaaggcg gaggcggcag ggaaggcggg
     7981 gcccttcgac aaggccgtcg aggtggcggt gcggtacgcg gaggcgctgg agaacaaggc
     8041 gttcgggctg gggccgggcc cgtcggcggc gctgcgcgtg cagcaccagt tcttcgacaa
     8101 ggtcgtctac ggcaaggtgc gcgacgcgct gggcgggcgg gtgcggcacg ccatgtcggg
     8161 cgggtcgggg atggcccggc ggctgggcct gttcttcgag ggcgcgggcg tcaccgtgta
     8221 cgaggggtac gggctgacgg agtccgcgtc ggcggccacc gcgaacccgc ccgagcggac
     8281 caagtacggc accgtcggcc cgcccatccc gggcacgacg gtgcacatcg cggacgacgg
     8341 cgaggtgtgg ctgcgcggcc cgcacatctt ctccggctac ctgggcgacc ctgccgcgac
     8401 cgccgccgtg ctccacgacg gctggctggc caccggtgac ctggggaagc tcgacgagga
     8461 cggctatctg accatcaccg ggcggaagaa ggagatcctg gtgacgtcgg gcggcaagag
     8521 cgtgtcgccg gccggcctgg aggagcgggt gcgctcccat cccctggtgg cgcagtgcat
     8581 cgcggtcggc aacgaccgcc cgtacatcgc cgctctggtg accctcgacc tggaggcggt
     8641 cgagcactgg ctggccatgc agaaccggcc gcccctgccg cccgccgagc tggtgcgcga
     8701 cccgtcgctg gagacggaga tacggcgggc ggtggtggcc gcgaacaccc tggtgtcgca
     8761 ggccgagtcg atccgtacgt tccggatact ggcgcatccg ttctcggagg agcacggcct
     8821 gctgacgccg tcgctgaagc tgaagcggaa ggcgatcgag gcggcgtacg cggcggaggt
     8881 cgaggcgctg taccggtgac cggccgccgc gcgcgcccgt ggtgtcagcc gatcgtgacc
     8941 tcgaggatcc ggtccgagcc ggccggctgc ccgccgttgc cgtccgcgtt ggtcgtggac
     9001 agccacaggt gcttggcgcc cggcaccgtg gtgacggtgc gcagcctgcc gtacgtcccc
     9061 acgtagtacg ccgtcgccgt gccgacctcc tcggtgccgg cgtcgagagg gatccgccac
     9121 agccgttggc cgcgcaggga cgccatgtag acggcgccgt cggcgacggc gatgccgctc
     9181 ggggacgctt cggcgacgcc ccaggtcttc ttcgggtcgg tcatgccggc gacgccgcag
     9241 gtgccttcgc aggccggcca gccgtagttg gcgccgggct tgatgaggtt gagctcgtcg
     9301 cgggagttct ggccgagttc cgcctcccac agccggcccc gctcgtcgaa ggccaggccc
     9361 tgcgggttgc ggtggcccag gctgtatacg agggtgccga aggggttgcc gggggcgggc
     9421 ctgccgtcct tggtcatgcg gaggatcttg ccgttgaggg agttcctgtc ctgggcgagc
     9481 gaggtgacct gggcgtcgcc ggtcgaggcg tacagatacc cgtcggggcc gaaggcgagc
     9541 cgtccgccgt tgtggtaccg ggccttgcgg atgccccgga cgatcgtggt gtagccggtg
     9601 agggtggtcc cgtcgtaggt catgcgggcg atgcggttgc cctcggacga cgtgtgcatg
     9661 aagtacacgt gcctggtggt ggcccagccg gggtcgacgg cgacccccat gaggccccct
     9721 tcgccgcccg tggtctggga gttgggtacg gtgccgacgc gcgtccgcgt gccggacggg
     9781 gtgaccttgt acaccgtgaa ggtgtcgcgc tcggtgacga gggcggcgga gccgtcgggc
     9841 agccaagcgg tgccccaggg gatggtccag ccggtggaga gggtggtgac gccggtgggt
     9901 tcgctcgcgg gggcggtcgc ggcggaggac ggcggtacga ggccggtgag gagcgcggcc
     9961 gcgccgaggg cggccgcgag gagggtcctg cgtgtggggg tcatcggggt ccttccgtgc
    10021 ggtaggagta gccggagccg gtgctcacgg cggccgcgtc gacgagggcg gtgacgagtc
    10081 cgtggtcggg ggacttgcgg caggcggggt cggtgcgggt ggcgtcgccg gtcagcgcgt
    10141 acgcctggca gcggcagccg ccgaagtcgc tggtgcgcag ctcgcagctc cggcacggtt
    10201 cgcgcatcca ctcctcgccc cggtacgcgg tgaaggccgg ggactcgcgc cagatccagt
    10261 ccagggcgtg gtccttgacg ttcggcgcgc cgagccccgg cagggcggcg gcggccgggc
    10321 agggcaggac ggtgccgtcg gggtggacgg tcagggacac ggcgccccag ccgcccatgc
    10381 agggcttggc ggtgccgtcc acgtagtcgg gtgcgaccca caccaggtcc aggcgcccgg
    10441 ccagccgctc ccgccaccgt gcgacggcct cccgtgcccg ggccacctgc gcccggtcgg
    10501 gcaggagggc ggcgcggttg cgcagcgccc agccgtagaa ctgggtgttg gccagctcga
    10561 cgcgctccgc gccccaggtg agggcgaggt ggacgaggtc gtcgagcgcg tccaggttgg
    10621 cgcggtgcag gaccacgttg acgccgagcg ggaggtccgc ctcccgtacg aggcgggcgg
    10681 cgcgctcctt ggcggtgaac gccctggctc ccgcgattcg ttcggcggcg gccgggtcgg
    10741 tgtgctgaac ggacagctgg acgctgcgca gcccggccgc caccaggccg cgcagccgct
    10801 gcgcggtgag tccgacgccg ctggtgacga gctgggtgtg gatgccggcg ccgtcggcgg
    10861 cggccacgat ggcgtccagg tcgcggcgca gcaggggttc gccgcccgac aggtgggtct
    10921 ggacgacacc gagagcggcg gcctgccgga agacgcccgc ccactcgccg gccgtcaact
    10981 ccgccgagcg ggcgaccagt tcgagggggt tggagcagta ggcgcagcgc aacgggcagc
    11041 cgtgggtgag ttcggcgagc agcgcccacg gcggtggggg cggcggtgtc atgtgagcca
    11101 gccctccgcg cgcagcctcc cgaggaagtc gggcacctcc tcggcgacgg gcgcgcccgg
    11161 gtggcgggcc tggagcgcgg ccacgatgcc gtcgacgtcc cgcgcgccgt cgcagagccg
    11221 caggacggac ccggcgttgc cgtgcaggac gacgacccgt tcgggcagga cgagcaggtc
    11281 ggtgccgcgg acgtggtcgt gccggagcat cacggaccgg tgcagcgccg gccgccacgt
    11341 accgctgccg ccgcccgggc cgctgccggc gctcaggccg ctgccgctgt cggcgctcag
    11401 gccgctgtcg gcgctcatga cctgcctccg gcctcgacgg cgtcgagcag cgaccacagc
    11461 acgtcgcact tgaaggcgag cgcggccacg gcccgctcct gctcctcgcg ggtgcgcgcc
    11521 cagtccagga ccagggtgag cgcctcggcg ctgtcgcggc cgccctgccc gatccggtcg
    11581 cggaagtagg ccagcccgtc cgcgtcgatc cacgggtagt gggtctcgaa cgcctcgatg
    11641 cgggtgcgca tgagggtggg cgcggacagt tcggtgaggg aggcggcgac ggcttcgagg
    11701 cgggggcgca gccggcagaa gttgacatag ccgtcgacgg cgagccgtac gccgggcagc
    11761 accccgtcgc ccgacgtgag gcgggcgcgg tcgatgccgg cggcctcgcc gagccgcagc
    11821 caccgctcga tgcctccctg gccgtccttc tcgccgtcgt ggtcctggat gcgccgcagc
    11881 caggcgcggc gcagcgcggg cgtgtccagc ttggcgagga cgagggcgtc cttgacgggg
    11941 atgtggcgct ggtagtggaa ccggttgagg atccagcggc gcagttcggc gggggtgagg
    12001 gtgccgtcgt gcatgcggac gttgaagggg tgacggtcgt ggtagcggtc ggtggcgacg
    12061 gcgcgcagcc gcgccgtgaa ctcctcccgg ctccaggtgc tcacagctcg atcaccatcc
    12121 ggtcggcggc gacgtgcagg ccccgtgcgg cgagcagcgc gtgctgcggg gcgtggggat
    12181 cggcgagggg gttggtgttg ttgaggtggg tgtagaggca gcgggcgggc agggcggcga
    12241 gccggtgggc ggtgccgccc ggtccgtcga tgggcaggtg ccccatggcg gtggcggacc
    12301 tggtggagaa cccgctgcgt acgggttcgt cgtcgtccca gaacgtgccg tcgacgatga
    12361 cgcagtcggc gtcctcggcg gcgtactgga actcctcggt ccaggcggcg agcgcgggtg
    12421 cgtagaggag ggtcccgccg gtggtcgtgt cgcgcagccg gagggcgacg acccaggtgg
    12481 ggtcgtcggg gccgttgtcc gtggcgtacc ggggccgttt ggcggagacg ggcacggcgt
    12541 cgatctcgat cgtcccgccc gcggtgagcg gctgcggctt ggtgctgagc tctcgccatt
    12601 cgatacgggt gtagggggcg agggtgtctc cgaggcggag gtggtcgagg agcgcggtgc
    12661 gtacgggtgg ggtggcgagg atctcgaagc cgtcggcctc gcggaggcgg gcgatgccga
    12721 gcgtgtggtc gagttccgcg tcggtgagga ccacgccggc gaggggcgtg tcccgggggc
    12781 cgggccccgg ccacagctcg cgggcggcct cgatctgttc gccgaggtca ggggtggcgt
    12841 tgacgacgta ccagcagccc tcgtcggcgc ggagggcgag cgaggcgtga cggcggcgcc
    12901 gctccgggtg ggcgcgtgcc ccggcgcagc cgggacacgc gcagttccac tggggcagcc
    12961 cgccgcccgc cgcggtgccg agcacctgca gcagcatggc ggcggggtct accggtcggc
    13021 gaggaagtag gcggtgactt cgagggcggt ctcgacgacc gtgtactcgg gggtctgcca
    13081 gaggaccgac gcggcggccc tctcctcggc gttctcgtgg gatgcgaacg attcctgcat
    13141 ggccggacct gctttcctga gaggtggggg ttcaggagtg ccgaacgcgg ctattcaacc
    13201 gttcagatgg gcgcatcgcg ttcagcgacg tgcaatagag tcgcgcgttt gatgggacgc
    13261 ggtcaatgcc gcgtcccggg aacacgttcc aggatgtgat cgttgtccct gggagtacca
    13321 accgacgacg ttaggatcga ccgctcgtga gcaaggtccc ttccctcacc ctccacaacg
    13381 gcgtctcgat gccgcagctc ggcttcggtg tctggcaggt gcccgacgac gaggcggcga
    13441 aggcggtggg cacggccctg gaggccggat accgcagcat cgacaccgca gcgatctacg
    13501 agaacgagaa gggcaccggc gaggccatcg ccgcctccgg tatcgcccgt gacgagctct
    13561 tcgtcaccac caagctctgg aacagcgagc agggccacga ctcgacgctg cgcgcgttcg
    13621 acgcctcgct ggccaagctc ggcctcgact acgtcgacct ctacctgatc cactggccgc
    13681 tgccctcgaa ggacctgtac gtcgacacgt acaaggcgct ggagaagatc tacgcggacg
    13741 gccgcgccag ggcgatcggc gtctccaact tcctgcccga gcacctggag cgcctcctcg
    13801 gcgagacctc cgtcgtaccc gcgctcaacc agatcgagct ccacccgcag ctccagcagg
    13861 ccgagtcccg ggcgttccac gcccgccacg gcatcctgac cgaggcctgg tcgccgctcg
    13921 gccagggcaa gggcctgctg gaggtgccga cgatcgtcgc ggtggcccgg aagcacggcc
    13981 gtacccccgc ccaggtggtg ctccgctggc acctccagct cggcaccgtc gtgatcccca
    14041 agtccgtgac cccctcccgg atccgggaga acatcgacgt cttcgacttc gagctggacg
    14101 ccgacgacct ggcggccctc gccgccctcg acgaaggcaa gcgcctgggc ccggacccgg
    14161 ccacgttcga ctacagctga gcctcacgta cggctgagcc ccacggctca cgggaacggc
    14221 gcgggccgcg tgtggtgcgg ccgcgccgtc cgcgccgtgc ggggcgtgcg tacgggtcag
    14281 gtggtcagca ggcggttgaa gaacgaccgg tactggcgga gcgccttgcg gaggtcctcg
    14341 gtgtccacgt cctcgccgcg gttccactga ccctccaggt ccttcttgtg gtcggcgaag
    14401 gtcgaggcca gttgccgcat gacgtccgcg acgagggcgt cggccttgtg cacggcctcg
    14461 cgggggtcgt cgacgaactg ggtctggacg tcctgccagc gggtccggaa gtcctcctcg
    14521 tcctcctcgg ccaggagccg cggtgtctcg tcctcgtcgt gttccgccgg gacggccacc
    14581 tccggggccg tgggcggggc cgatccggcc ggctccgcgg tgctctccat cgggaaggcg
    14641 ggggcgtccg gccgctcccc ggtggcttcg cccgcgccgc ccggctgggc gatgtcctcg
    14701 gtggacaggc cgctctcgcc gggtcctggt atgtcctcgc gttgcatgtc tcctcctccg
    14761 ccgtggtcgg cgccgggtca ggccggggcg cggtgggact ggcccccgtc ggacagcagc
    14821 tcgtcgaaga gggcgcggta gtgcaccatg gctccgcgca gctgctcggt cgtggcctgg
    14881 tgcttcatgc tcagcctgtt gacctcgtgc gcggcacggt agtgctcgat cgtgcggccg
    14941 tgctcgaccg acaggtcctt cagccgctgg tcgaggtcct cggtcgggta gccgcgttcc
    15001 cgcatcaggg aggtcaccag gaggtccgcg tcctgcacgg cgtcctccgg gcggtccacg
    15061 aattctccct gcacgtcggc ccagtcccgg gtgtagcggt cccgcgcctc acccggcagc
    15121 ggcctgatgt ccagctcgtc gtggcgtttc tcgcgtgcgc tcagatcgcg ctcggcggcg
    15181 agccggcttc cggtgtcctc gaccgtcctt tcgtactccg gtccgaaccg ctcacgcagg
    15241 cgccggctgc ggaagccgag aaaggcgacc acggccagag cggccaggat caccgcgacg
    15301 ggaatgatga tcgccaggag cgtccctgtc gacatgggac cgaccccctc acatcgtgtc
    15361 cgatatgccc cattcagggt atcgctgacc cctgaccagg ggaacggccg ggggcgagta
    15421 gggtgaaatg attgtcattc gccgctgcgg ataaggtgtg gctccatgaa cccagccgca
    15481 cccgcgcggg agcgcgcgcc cggcgcgata ccgccgtccg tcgccgtcac cggagccgta
    15541 tcgctgctgc tgatcgccgc gctcgccctg cccgtgctga accacccggg cttccgggcg
    15601 tggcagacca tatgtgtggc gctcaccgtg caggcgctgc cgttcctgct gttcggcacc
    15661 gttgtctccg gggccgtcaa cgccttcgta ccggcacggg tgttcagccg ggcgctgccc
    15721 cgcaaccccg cgctggccgt gcccgtcgcc ggtgccgccg gtgtggtcct gccgggctgc
    15781 gagtgcgcct ccgtgccggt cgcggggagc ctgatccggc gcggggtcac cccggccgcc
    15841 gcgttcgcgt tcctgctgtc cgcgccggcg gtcaaccccg tcgtgctggt ctcgaccgcc
    15901 gtcgcgtttc ccggacagcc cgggatggtc gccgcccggc tcgtcgcatc gctcgcgacg
    15961 gcggccacca tgggctggct gtggctgaag tggggccggg cggaatggct gaagatgccc
    16021 gcgcgccaca ccggccaccg ggccgggcac agccgctggg aggagttccg ggtcgggttc
    16081 cagcacgact tcctgcacgc gggcggcttc ctcgtcgtcg gcgcgatggc ggcggccacc
    16141 ttcaacgtgc tcgtcccccg ctccgtactg gacgtcttcg ccgactcccc ctggctgtcc
    16201 gtgctgttcc tcgccgcgct cgccatcgtg ctcgccgtct gctcggaggc cgacgcattc
    16261 gtcgccgcgt cgctcaccgg cttctccccc accgcgcggc tgacgttcat ggtggtgggg
    16321 ccgatggtcg acgtgaagct gatcgccctt caggccggga cgttcgggcg ggccttcgcg
    16381 gtgcgcttct cggcggcgac cgcggtggtg gccgtggcgt gtgcgtgcct gaccgcctgg
    16441 tggctgctgt gagacggcac atccaggcgg ccctgctgct gctcaccggc tccgccgtcc
    16501 tgcacatctc gctgctgagc caggtctatc tgcggtacgt gaaggagggc ttgcggccct
    16561 tcctgatcgc gtccgccgtg ctgctgctcg cgctgggcct catcagtgcc gtacgggacg
    16621 ggctgccgtt cgcgccacgg cgcccggacg acgagcccct ggacgacgga cacggacacg
    16681 gccacgggga cggcgggccg cgcgtcgcct gggtcctctt cctgcccgtg ctcgccctgc
    16741 tgctgtacgc cccgcccgcg ctcggctcgt acaccgcggc gcgcgagacc gacaacctga
    16801 tcgccccggt gtcggagttc cgtccgctcc cggacgccga cccggccccg ctcgccctgt
    16861 ccgggttcat cgcgcgcgtc cagcaggacc gcgaccggag cctggccggg cgtacggtcc
    16921 tgatgaccgg gttcgtcacg cccgcgaacc cgcgcgccaa ggacggcacc tggtacctga
    16981 cccggctcgt ggtcagctgc tgcgcggccg actcccagtc gctgcgcatc cgcgtgtacg
    17041 gcaggcccgc gccctccgcc gacacctggg tgaccgtgac gggcacgtgg caccccggcg
    17101 gcggcggtga gctcgggacg gcgacggccg cggtggcgct cgacgcccgg acggtggagc
    17161 gggtgcccga gccggtcagc ccgtaccagg acaccccgcc gccgccgccc tgatgacggg
    17221 tcggcccgtc ccggacacca cgcccccgct gccctgaggg gctcagcccc ggcgggccgt
    17281 gtgcaccgtg cgggccgtca gcaggaacac gtccggccgg tggtgcaggc tctgcgggtc
    17341 ggccgggtcc agcagccggt cgagcgtggc cacgtcctcg ggcgcgaggc gctcgcccag
    17401 cccgtcgcgg tagcgggcga agacggtcac gatctgctgc cgtacggcgt cggtgacggg
    17461 ggccggcatg tcgtggagga aggtgcgggt gccgctcggc acgaggcccg cgccggacag
    17521 cagggcccgc cagtcgtcca cgtcctcctt ggcgccgggc agccccgccc gcatctcggc
    17581 gaaccagtcg gcgtgcaccg cgtcgatgcg ggcctccagg cccggccggc cgatgccgaa
    17641 gttgtgcggc aggcgccgcg tgggcagccc gccctcgacg accgccagca ggccaccggg
    17701 gcgcaagcgg cccgccagct ccgcgacggc gccgcgctgg tcgcccaggt ggtgcaggga
    17761 gtcggccgcc cagatcaggt cggcgcggcc cagcccggcg atgccgcccg gcaggtcggc
    17821 atggtgcgtg gtgacccggt cgccgaggga cgcggcacgg gcgcgctccc gggtgcgctc
    17881 caggagctcg ggcgtggcgt cgacggcgac gacctcggcg tacgggaacg cttcggcgag
    17941 caggcaggac agcacgcccg gcccgctgcc gatgtcgagg atccggcgca ctccggccgc
    18001 cggtgccagc tcgccgagcc aggccgcggc ctgccggtac agcgggccct ggagctccgc
    18061 gccctgttcc agcagcggca gcatctcgtt ccagtccatg tgggtgtcat cgtggtcgtg
    18121 gtgaccgtgg tggtgtcggc tcatgcggac agggtggcgg cgcggtgccg tcatggcgag
    18181 ctttgttgct gcttcggcaa caggtggcgt cgcctcgcgc ggtgctcccg cgggccgact
    18241 ccccggaccc gcttgaacgc cgcgcttagc gcgaacgagc cgctgtagcc cacctgccgg
    18301 gccaccgact cgaccgtggc gtccgtggtg cgcagcaggt cggcggcgag ggcgagccgc
    18361 cagcccgtca ggtacgtcat cggcggctcc cccaccaggt cggtgaagcg gcgcgccagc
    18421 ccggcccgcg acacgccggc ctcggcggcg agcgaggcga ccgtccaggg acgcgccggg
    18481 tcgttctgca tcaaccgcag cgcggcgccg accaccgggt cgcccatggc ccggtaccag
    18541 cccggtgccg ccgcctcggg gcgggagaac caggcgcgca gggcggcgat cagcagcagg
    18601 tccaggatcc ggtcgaggac gacgctctgg cccggctcgt cccggccgat ctcctcctcc
    18661 ctcaccggca tgacggggca gttcccctgc tcggcggtca ggtgcagcag cggcggcagg
    18721 gcgtccagga ggcggcggcc gacctcgctg tccatccggt acgtacccac acggccggcc
    18781 gccgccctcc gggacggaca gcggctccgt gcgcggcacc gcgtcgaggc cggccggcga
    18841 gagcagcggg ccggctgggg cggccggaaa ccggcccggc accaggatcg tccgcgctgc
    18901 ccggcgcgct ggggcgacct cctccgggcc ggcgcgcgga ccgctgcgga ggtgcccggc
    18961 gcaccgtccc ggaacgcggc ggcggccgag gcgttccggg cggacccgcc ggcagcccgc
    19021 catgggaaac gacgtcctac gcgccggccg cgtaccgttc cgccactgcc cgggccgtct
    19081 cggcgaggcg ggtgcgcagt tcgtccggtg cgaggacctc cacgtccgtg ccgagcgcca
    19141 ggaactggtc gtgggcgtgg tccggcgact cgacggggag cacggcgcgc gtccacccgt
    19201 ccggctcgtc ggtgccggtc gtggcggcgg cccgggcggc ggcgcccgtc aggcgggcca
    19261 caccccgggg cgagaggcgg acgagggcct cgccccggtg caggcgggcg tggaagtcgc
    19321 gctggtgcgc ctgccagtac gcggacagat cgaagtcgtc cggtacgtcg aactcctcgc
    19381 ccgtgaccgt gagttccagg atctggtcca cccggtacgt acgcggcccg gagccgcctg
    19441 gccgtgccgc cacgacgtac cagcggcccg ccttgagcac caggccgtac ggttccaggc
    19501 ggcggccgac gtcggtcggc tccgtccagc ggcggtagcg gacggcgagg accctgccgc
    19561 gccagaccgc ctccgcgacg gccggcagga acggtacggc gtcgtcctcc gcgtaccacc
    19621 cgggcgcgtc caggtggaac ctgcggctca tccggtcggc ctgcgcccgt agtccgggcg
    19681 gcagggcggc gcgcagcttg agccgggcgc ccgcgagggc ggggccgagc ccgaggtcgg
    19741 ccgccgggcc ggggagcgcg gtcaggaaca gcgcctcggc ctcaccggcg gacaggccgg
    19801 tcagccgggt gcggaagccg gcgagcagtt cgtagccgcc gcggtgcccg gcgtccccgt
    19861 acagcgggac gcccgcggtg tgcagtgcct cgacgtcccg gtagacggtg cggacggaga
    19921 cctccagctc ggcggcgagc tgggcggcgg tcatgcggcc ccgggtctgg aggaggagca
    19981 ggatcgacag cagccggctg gacttcactg acacagggtg tcagtgaacc gctcgtaccg
    20041 tccagccatg cctttcgcag agaagtacct cttcgtcccg ccgccggtcg aggccggcgg
    20101 ccgccgcgtc aagcgctacc acgtcaccgc cgacccgtcc ggcatcgcac cggacgtgga
    20161 gaaggccgcg tacgcgctgc tgcccggcct gctcccggag ccggacggga ctcccccggc
    20221 gtcgttcagc gtcctgcacc gcggcgggga cgacggcgcg tacctcaaca cctacacctg
    20281 ggtgtgggac aacgtcctgc actgcgccat cgccgtggcg gggcagccgt cgctgggctg
    20341 cccggaccgg gatcccacgc atttcgtacg cctggacaag ccgtggatcg gctgcgtctg
    20401 ggagcttccg ccgctcgcgc acgaacggga cgcgtgggta cggcacatgc tcgcgccgga
    20461 ccgccccgac ctcgacgcgt acatggccga ctcgctcccc gagggcacga cgggcggcac
    20521 gcgcgcgtga acggcttcga cttcctcgaa ggccgctgga acgtccacaa ccgcatgctc
    20581 gccgacttcc tcgacccagg cagcgggtgg gaggagttcg acggccacac caccggacat
    20641 ctccactgga gcggcgccgc ccacgtcgac gaggtcgtct tcccctcgaa ggggttttgc
    20701 ggcctgaccg tgcggctgta cgagccggag accggtgagt ggacgctcaa ctgggccgac
    20761 agccgcacgg gccgcctcga accgcccgta cgaggccgct tcgacgcgga cggtacgggg
    20821 cggttccacg gcgacgacca ctacgcgggg cgggccgtcc gggtccgctt cctgtggtcg
    20881 ggcatcacgg ccaccacggc gcggtgggag caggccttct cggtggacgg tgaggagacc
    20941 gaggagacct gggtgacgaa ccgggtgatg accttcacgc gcgcgtagac cgtcagttcg
    21001 cgccgtggac gggcgcgatc tcctcgacgc gggcggcgag ggagaagtcc ttctccgtga
    21061 tcgcgccgcc cgcgtcgtgg gtgttcacgg tgaggttgac cgtgttgtag ccgagggtga
    21121 ggtcggagtg gtggttcagc tcctcctgga tccgggcgac gtggacgacc atcgcggtgg
    21181 cggcgaagtg cgtgcccagg cggtaggtgc gggcgatccg gtcgccctcc tgggaccagc
    21241 cgggcagttc gcgcagccgg tcctcgatct ccttctgcga cagcggctca gtgggcatgt
    21301 cccgtgctcc ctccgggtcg gtacgggcga tgacgacgtg accgtgacga tacggtccga
    21361 cggcaccggt ccgtggtcaa cacgtgggtt accgtctgcg gtatgacaac tgtcgtgtcc
    21421 ggtaccggag tagggccgct gctgcgcggc tggcgtgagc gccggcggct gagccagctg
    21481 gagctggcgc tgcgcgccga ctcgtcggcc cgtcacatct cgttcatcga gacgggccgg
    21541 tcccgtccga gcgaggatat ggtcctgcgc ctggccgagc acctggacgt gccggtgcgg
    21601 gagcgcaacg ccctgctgct ggcggcgggt tacgcccccc ggtacgccga gacgtcgctg
    21661 gacgacccgt ctctgggcac gctgcgggcg ggtatcgagc agttgctggc cgggtacgac
    21721 ccgtatccgg cgctcgtcgt cgacggctcg tacacggtgg tggccgcgaa ccggggcatc
    21781 tcgttgctgc tggacgggct gcccgagcac ctgctgacgc cgccgctgaa cgccatgcgc
    21841 gtcaccctgc acccggaggg cctggcgccc aggatccgca acctgcgcga gtggcgcggg
    21901 cacctgctgg cccagatgca gcggcagatc gcgctggccc gctccgagcc gctgcggcgg
    21961 ctgtacgagg aggtcgcggc gtatccgctg ccggagacgg ccggcgaccg ggacgaccgc
    22021 gaggagccgg ccccgtactt cgcactgccg atgcggatcg agcacgacgg tcaggtgctg
    22081 tccttcgtgt cgtcgatctc gacg
//
