LOCUS       NZ_LIWA01000007        22163 bp    DNA     linear   CON 28-MAR-2024
DEFINITION  Streptomyces sp. CB01883 scaffold7, whole genome shotgun sequence.
ACCESSION   NZ_LIWA01000007
VERSION     NZ_LIWA01000007.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CB01883
  ORGANISM  Streptomyces sp. CB01883
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 747387)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 747387)
  AUTHORS   Yan,X., Ge,H., Hindra,F., Yang,D., Huang,T., Crnovcic,I. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-AUG-2015) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2014
            Assembly Method                   :: CLC Genomics Workbench v. 7.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905855.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:34:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,089
            CDSs (total)                      :: 8,009
            Genes (coding)                    :: 7,788
            CDSs (with protein)               :: 7,788
            Genes (RNA)                       :: 80
            rRNAs                             :: 3, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 221
            CDSs (without protein)            :: 221
            Pseudo Genes (ambiguous residues) :: 0 of 221
            Pseudo Genes (frameshifted)       :: 85 of 221
            Pseudo Genes (incomplete)         :: 169 of 221
            Pseudo Genes (internal stop)      :: 25 of 221
            Pseudo Genes (multiple problems)  :: 50 of 221
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:33:31
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 470723
            Orig. end                         :: 492886
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LIWA01000007.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22163
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="6"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22163
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22163
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12163](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12163)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     misc_feature    402..415
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.33"
                     /tool="antismash"
     gene            669..1649
                     /locus_tag="AMK32_RS31055"
                     /old_locus_tag="AMK32_30480"
     CDS             669..1649
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005310105.1"
                     /locus_tag="AMK32_RS31055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_30480"
                     /product="MCE family protein"
                     /protein_id="WP_073899137.1"
                     /transl_table=11
                     /translation="MKPFRERNPVVIGAVGLAVLALLTVAAFNADSLPLIGGGDTYSAA
                     FSEAGGLKPGDEVRIAGVKVGKVEAVDLDGDHVKVAFKVNGRPAFGTDTGAAIRVKTIL
                     GAKYLALYPKGPGRLEAGSEIPLGRTVSAYDVVQAFSDLTTTTEEVDTDRLAKALDTIS
                     VTFQDSPEEVRASIKGLSRISRTVAARDKALRGLLDHANGVTKILAGHTKDFSALMKDG
                     DALFKEIDKRRTAIHTLLKSSALLGVELSGLVDDNSKEIGPALKNLNTFVTMLERNQSS
                     LDRSVRLLAPYIRLFSNTLGNGRWFDSYIQNLVAAPVTPRTGGTR"
     gene            1646..2758
                     /locus_tag="AMK32_RS31060"
                     /old_locus_tag="AMK32_30485"
     CDS             1646..2758
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003989831.1"
                     /locus_tag="AMK32_RS31060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_30485"
                     /product="MCE family protein"
                     /protein_id="WP_198960495.1"
                     /transl_table=11
                     /translation="MTRRLLALFPALALLIGLAVILWPAAPGPVRVTAYFPRTVGIYPG
                     SDVRVLGVRIGEVREITPEGDRVRVELEYDRGRRIPADAQAAIVNSSVVSDRYVQLMPV
                     YRKGAELRDGDVIPESRTAVPVELDRIFDSLHTTAEALGPNGANKKGSLSRLLGVSADN
                     LQGQGENLHQTVRDLSQAVTTLSDGRGDLFGTVRNLQVFTAALAADDTSVRSFNSDLAV
                     VAGQLAGERKDLAAALKYLAVALGDVSGFVKGNKKALTSNVRGLAKVTKVLVTQRKALE
                     ELLTVAPTGLSNLQNAYDPAAGTLDTRNNPQSSQDPASVLCSILKTTGKDHDDCADLKK
                     LFDSLPELPSAPASTGTVDKTLGGILKAPA"
     gene            2755..4047
                     /locus_tag="AMK32_RS31065"
                     /old_locus_tag="AMK32_30490"
     CDS             2755..4047
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010987297.1"
                     /locus_tag="AMK32_RS31065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_30490"
                     /product="MCE family protein"
                     /protein_id="WP_073898604.1"
                     /transl_table=11
                     /translation="MSARRKGRTAAWAAVGSLLLTGCEFNGWYDVPLPGGAASDGHAYH
                     VTVEFRDVLDLVPQSAVKVNDVTVGAVEKVELDGWHARVRLRVADSVKLPGNAIADLRQ
                     TSMLGEKYVALSAPAGTRPLGRLRDGDRIPLSRSGRNPEVEEVLAALSALLNGGGVAQL
                     KTITVELNKALGGREDRVRSLLKQLDTFLGGLDDQRAEIVRALKGVDRLAKRLKKEKKT
                     IALAVDTMPPALKALADQRKDLTKMLTALSGLGKTATKVVNASHDDTVADLKKLQPILR
                     KLNKAGDDLPDSLEILTTYPFPRNATDAVKGDYVNLKITADLDLANLYGNITGKPGKGR
                     KSPAPGAPHLPSLPTPAPLPSLPSVPSLPSTPSLPSTPPVPSAPPTPSDGSSLLCPPVC
                     TAAYSTRGGARRLPSGIDLGLAELMLKGILP"
     gene            4044..5330
                     /locus_tag="AMK32_RS31070"
                     /old_locus_tag="AMK32_30495"
     CDS             4044..5330
                     /GO_process="GO:0015914 - phospholipid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004001710.1"
                     /locus_tag="AMK32_RS31070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_30495"
                     /product="MlaD family protein"
                     /protein_id="WP_073898606.1"
                     /transl_table=11
                     /translation="MITRTVRTQLLAFTAVTVLGVSYVGARYTGLVDDVLHRGYTVRAD
                     FAESGGIFSGAEVTYRGVPVGRVGDLRLTGSGVSVALKIEDGARIPADTLAVVADRSAV
                     GEQYVDLQPRRSGGPYLTDGSPIPRSRTRTPLAVTDLVLSLDRLVNSVGKDDLRVTVDE
                     LGKAFVGTGPNLSRLVDSGDSLVESASESLPQTVSLIEDSRKVLKTQADKGSAIKSFSR
                     DLATLTAQLKSSDGDLRRLVGNTPPAAQQVDSLLRSTRPHVPVLLANLISGGQITLARL
                     PGVEQALVTLPLTVAGSYTVIPGDGTTHFGMTVNADDPPACTQGYGTRRRDPADTSTRP
                     ANTDARCTVPRGSKTSVRGAQNAPGPTTGRYSADRAAFVAPYDPETGTATGPDGTPVEI
                     GSTGGEKTVFGKESWQWLLVGPMAGEAHA"
     gene            5288..5800
                     /locus_tag="AMK32_RS31075"
                     /old_locus_tag="AMK32_30500"
     CDS             5288..5800
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003989828.1"
                     /locus_tag="AMK32_RS31075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_30500"
                     /product="hypothetical protein"
                     /protein_id="WP_073898608.1"
                     /transl_table=11
                     /translation="MAARGTDGGRGARVRLLSAGLAAATVLTTVPCVWLGVRLSDQHAV
                     EQRRQDILAAARQSALNFTSLDYRHYDRDSGNVLKGATGEFKKEFAAQTAQLTKLVAQN
                     KSVSQGQVLEAGIVRSDARSARVLVVADSKVTNTGAPEGQARTYRLQLDLTRVAGRWLT
                     SDVTFVG"
     gene            5835..6587
                     /locus_tag="AMK32_RS31080"
                     /old_locus_tag="AMK32_30505"
     CDS             5835..6587
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009313589.1"
                     /locus_tag="AMK32_RS31080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_30505"
                     /product="hypothetical protein"
                     /protein_id="WP_241841283.1"
                     /transl_table=11
                     /translation="MAIPTSRTRGTGSPARRTMTAAARAAAKRAGRPVRPERGADQDER
                     TPSGRTLLVEPPTNGWEDPPEPESFEEEPEDGARPRKAGRPGVLTAVLGVVLVAALITV
                     AVLGWQYVQERQTEQARGEAVAAAREAAPVVLSYDYRHLDRDFSRAHGLLTGHFRDQYG
                     KTTKAAVAPTATKYHGVVKATVATPADGSAPAVSVVSATPDRAVVLLFVNQVTRSTQVP
                     QPRLDLNRVRMTLTRTSDGWKVSGVDAL"
     gene            7014..7448
                     /locus_tag="AMK32_RS31085"
                     /old_locus_tag="AMK32_30510"
     CDS             7014..7448
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK32_RS31085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AMK32_30510"
                     /product="hypothetical protein"
                     /protein_id="WP_143611372.1"
                     /transl_table=11
                     /translation="MSCATAQPCDDYALKVSVPADFDAGHGLRIDVRWPDSAADFDLYV
                     LDADGREVAASASSGDPEAVLLPAVSASYTVRVVPYAPLGDSFTGTASLITAPVDPPPS
                     TATPPTYANSWAPDGITDAHNAGEPSIGVDRASGAAMFQA"
     gene            7692..8615
                     /locus_tag="AMK32_RS31090"
                     /old_locus_tag="AMK32_30515"
     CDS             7692..8615
                     /EC_number="3.2.1.-"
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK32_RS31090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AMK32_30515"
                     /product="sialidase family protein"
                     /protein_id="WP_073898614.1"
                     /transl_table=11
                     /translation="MDHQTIGGGPFAPGGPGALTSYRNAVYYCSQDIADASCAVSRDGG
                     LTYGPAVAMYSLLDCGGLHGHVKVAPDGTVYVPNKGCGDHQAVAVSEDNGLTWTVRKNP
                     SSTAGDSDPSVGIGAGGTVYMGYQNSDGTPRIAVSHDKGKTWLYDQNVGAALGIENVVF
                     PTVTAGDDNRAAFAFLGTTTGGNYQDPAFPGVWHLYVATTYDGGQSWVTADATPTDPVQ
                     RGSICTGGTTCGKDRNLLDFVDVTTDAQGRVLAAYADGCTGTCATGGAQNYDALASIAR
                     QSSGNTLYGAYDAVVSGKHKKPGGSH"
     gene            8616..9119
                     /locus_tag="AMK32_RS31095"
                     /old_locus_tag="AMK32_30520"
     CDS             8616..9119
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK32_RS31095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AMK32_30520"
                     /product="hypothetical protein"
                     /protein_id="WP_073898616.1"
                     /transl_table=11
                     /translation="MRPSLSAAVLVGAVLSLAAVTGCSAAGNHAERPGATQDPVKRATE
                     APAGNKAGAAPDGCPTAASLPLPKDFPANLPVPDGAVVTSVEHRTGGRLVVTTVVRGGF
                     DTTLAFLHTRLPKAGYIPEEGEVEEDDAESNFFTATVRGRWALRKMPDCGGGVYLTYLT
                     ADVS"
     misc_feature    complement(9336..9354)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 21.84"
                     /tool="antismash"
     gene            9399..9938
                     /locus_tag="AMK32_RS31100"
                     /old_locus_tag="AMK32_30525"
     CDS             9399..9938
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014671043.1"
                     /locus_tag="AMK32_RS31100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_30525"
                     /product="manganese efflux pump"
                     /protein_id="WP_073898618.1"
                     /transl_table=11
                     /translation="MIWEILVLGFVLSLDNFRVSIALGTVPFGLKRAVQVALTFGLWDA
                     VMPLVGLLIGHQIGESVGDVADVVGAGALGGYGLYLVISSLRNPEPDELDHPWALFGIP
                     LTLSLDNLFAGASLGVLGISPWFSAATFGVMTAVLSLVGLQLGRAAARLIRIRSDLLSG
                     VTLIIAAAALPLWFGN"
     gene            complement(10001..11140)
                     /gene="pqqE"
                     /locus_tag="AMK32_RS31105"
                     /old_locus_tag="AMK32_30530"
     CDS             complement(10001..11140)
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014671044.1"
                     /locus_tag="AMK32_RS31105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_30530"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_073898620.1"
                     /sec_met_domain="PF04055 (E-value: 6.7e-26, bitscore: 87.1,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 3.3e-09, bitscore: 32.6,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 6.4e-09, bitscore:
                     31.6, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDSPFGLLAELTYRCPLACPYCSNPLNMAGYQDELTTDEWRRVLA
                     EASELGVLQCHLSGGEPLLRRDLGEIVAHAHDVGLYTNLITSALGLSRSKAEELRAAGL
                     DHVQISIQADEPTVSDRIAGTPSFQRKIEAMGVVKELGWPLTMNVVLHRHNIDRVADVL
                     ALAEDVGADRLELANTQYYGWAWRNRDALLPSRAQLEAAEVVVRAARKRLRDRMDVIYV
                     IPDYYSRFPKPCMGGWASRQLTVTPNGDVLPCPAAQPLPLPRASVRDEPLERIWAESPI
                     MTAFRGTDWMPEPCRSCYRRELDFGGCRCQAFLLTGDAARTDPVCYLSPDHDLVVRAVE
                     AANADSRSDDPPLIPRPHRPGLPAIAPPQGRRGGRGHQG"
     gene            complement(11133..11462)
                     /gene="pqqD"
                     /locus_tag="AMK32_RS31110"
                     /old_locus_tag="AMK32_30535"
     CDS             complement(11133..11462)
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03859.1"
                     /locus_tag="AMK32_RS31110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_30535"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_073898622.1"
                     /sec_met_domain="PqqD_RRE (E-value: 1.8e-21, bitscore:
                     71.2, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 8.6e-15, bitscore: 50.3,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDPPPTGTTQTGTRTRPGVEVSDFDRPRLPRHVRLAFCRTRRRRI
                     LLHPETVVVLNGSGGAVIELCDGRHTVTEIVTELGARYQAVSEDEVRQFLTQLVSRRWL
                     ELTDG"
     aSDomain        complement(11145..11402)
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_AMK32_RS31110_PqqD_RRE.1"
                     /evalue="7.10E-23"
                     /identifier="RREFam006.1"
                     /label="AMK32_RS31110"
                     /locus_tag="AMK32_RS31110"
                     /protein_end="106"
                     /protein_start="20"
                     /score="71.2"
                     /tool="antismash"
                     /translation="VSDFDRPRLPRHVRLAFCRTRRRRILLHPETVVVLNGSGGAVIEL
                     CDGRHTVTEIVTELGARYQAVSEDEVRQFLTQLVSRRWLEL"
     gene            complement(11465..12163)
                     /gene="pqqC"
                     /locus_tag="AMK32_RS31115"
                     /old_locus_tag="AMK32_30540"
     CDS             complement(11465..12163)
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014671046.1"
                     /locus_tag="AMK32_RS31115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_30540"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_073898624.1"
                     /sec_met_domain="TIGR02111 (E-value: 2.5e-97, bitscore:
                     320.3, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTTTRTGADGFVETLRAHSRQYHDHHPFHVRMNAGRLSPRQIR
                     GWVANRFYYQENIPRKDAAILSNCPDLEVRRRWIRRIIDHDGTADGEGGIEAWLRLGEA
                     TGLTREEIRDHRHLVPGARFAVDAYVNFTRARPWVEAVASSLTELFAPDLMAARLQAFE
                     RWYPWIDPEGLAYFRSRLEQAPRDCEHALEVVTAHCLSAESQARAIDALSFKCDVLWSL
                     MDAIDQAYPE"
     misc_feature    complement(12151..12171)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     gene            complement(12168..13055)
                     /gene="pqqB"
                     /locus_tag="AMK32_RS31120"
                     /old_locus_tag="AMK32_30545"
     CDS             complement(12168..13055)
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018559515.1"
                     /locus_tag="AMK32_RS31120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_30545"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_073898626.1"
                     /transl_table=11
                     /translation="MLLRVLGSAAGGGSPQWNCGCPVCAAVRSRTGLARTQSSVAVSAD
                     HRRWFLINASPDVRTQIEAFPALHPRGDRTTPLEAALLTDSELDHTLGLLLLREARALR
                     LYTTPATHKTLCDGSGILRTLERYCPVEWHAATPGADLDLADGLSCRVFDVPTTKRARF
                     GAGVDHGRVVGYRLTDQRSGRTLVYLPGVQSLTPALRAEIEDCACLLIDGTCYRDDELV
                     RLGLSGKTSREMGHLPIDGPDGSLAQLPSLGAGRTIFVHMNNTNPILLEDAPERRTVEE
                     SGMQVAMDGLEVQV"
     gene            complement(13163..13294)
                     /gene="pqqA"
                     /locus_tag="AMK32_RS31125"
     CDS             complement(13163..13294)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: protein motif:HMM:TIGR02107.1"
                     /locus_tag="AMK32_RS31125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_073898628.1"
                     /transl_table=11
                     /translation="MEPQLTVWETPETQSQLAAWETPEFDEIAVAAEVTMYLDQLEE"
     gene            complement(13341..15050)
                     /locus_tag="AMK32_RS31130"
                     /old_locus_tag="AMK32_30550"
     CDS             complement(13341..15050)
                     /EC_number="1.1.2.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014671047.1"
                     /locus_tag="AMK32_RS31130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_30550"
                     /product="PQQ-dependent dehydrogenase, methanol/ethanol
                     family"
                     /protein_id="WP_073898629.1"
                     /transl_table=11
                     /translation="MTVDYADYVDAGEAVDQGALSGKVAGGEVAPPVVAGVDYERILNA
                     REEPQNWLTYYGAYNGQRYSPLDQINTENVKRMVPAWVFQAGTTGLIAGASTYSFEAAP
                     IVVDGVMFLSGWDGWVWALDAKTGVEIWRYKHAVPFDVSLCCGNVNRGVAVAQGKVFFV
                     TANARVLALDATTGKRVWDKTYGDVRAGESATVAPLIVKSMVIVGSSGGEFGVRGHLDA
                     FDLETGEHQWRCYTVPKPGEPGSETWPADGEAWARGGANCWVTGTFDPETNLLYVGTGN
                     PAPDFDGGVREGDNLFTDSIIAVDVDSGQIRWHYQCTPHDLWDYDSIAECILFEHDGRK
                     LLGHFDKNGYFFVLDRTNGERVQITPFVDRITWGAITRDGQVTAKVYPDKEGEPVHFYP
                     GPAGAKEWTHAAYSPKTELFYVPVQDTGATATRRRREFKESIPYWGAGVQVDIEDMAGS
                     ISAFDAGGEEKWRWRNELPMCASVLATGGDLVFAGEASGEFNALDARTGELLWQFQCGS
                     GHHSSPTTYMVDNRQYIAVPVGWGGWAEGFLPGMLGAGHGSALIVFALPEAA"
     gene            complement(15073..15534)
                     /locus_tag="AMK32_RS31135"
                     /old_locus_tag="AMK32_30555"
     CDS             complement(15073..15534)
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:1901661 - quinone metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018559512.1"
                     /locus_tag="AMK32_RS31135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_30555"
                     /product="MSMEG_3727 family PQQ-associated protein"
                     /protein_id="WP_073898631.1"
                     /transl_table=11
                     /translation="MTTAQERADLLDKIGLAAQNKAALGQVLGTGSIGQATEKSDGHME
                     ATIRIHPDELTFDPSILVMPHGGDIELELVNDDQNTHCALLPSNGDRKFIWLVNHSHGH
                     AHLNLDGPGYYWYASPTGNDEGRGLTGAIVVLGDAPPEARLDRPEQPRP"
     misc_feature    15649..15662
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.12"
                     /tool="antismash"
     misc_feature    15650..15663
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.81"
                     /tool="antismash"
     gene            complement(<15819..>15938)
                     /locus_tag="AMK32_RS43485"
                     /pseudo=""
     CDS             complement(<15819..15938)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010040282.1"
                     /locus_tag="AMK32_RS43485"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="type I restriction endonuclease subunit M"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLREGFDFRTGLRAEHEQRIDEVARAAYCAKTEQAARSAA"
     gene            complement(16040..18184)
                     /gene="katG"
                     /locus_tag="AMK32_RS31145"
                     /old_locus_tag="AMK32_30560"
     CDS             complement(16040..18184)
                     /EC_number="1.11.1.21"
                     /GO_function="GO:0004096 - catalase activity [Evidence
                     IEA]"
                     /GO_function="GO:0004601 - peroxidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="katG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018559511.1"
                     /locus_tag="AMK32_RS31145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_30560"
                     /product="catalase/peroxidase HPI"
                     /protein_id="WP_073899142.1"
                     /transl_table=11
                     /translation="MGGASNRDWWPNQLDLTILRTHRGVADPMGEDFDYAAEFRTLDLD
                     ALARDVDEALTTSQEWWPADFGHYGPLVIRMVWHCAGTYRIDDGRGGAGTSLQRFAPLN
                     SWPDNRNLDKARRLLWPTKKKYGRKISWADLMIFAGNRALETMGFRTFGYAGGRAEVWG
                     PDEGIFWGRERTWLGDERHVGVRELEHPLAAVQMGLIYVNPEGPNTVPDPLTAARDIRE
                     TFRRMGMNDEETVALIAGGHTFGKTHGAADPEAYLGPEPEGAPLEEQGLGWKSSYGTGK
                     GRDTISSGLEGTWTPTPTRWDNSFFETLFGYEWDLELSPAGLWQWIPRDGGGARTVPDA
                     HNPSTAHAPTILTTDLALRSDPVYEPISRRFLENPDQLADAFARVWFKLTHLDMGPIQR
                     YLGPLVPRETLRWQDPVPALDHELVGAADIAALKSRILASGLSVSQLVSTAWASASTFR
                     ISDKRGGANGARIRLEPQRNWEVNDPDKLAQVLHTLEGIQESFNSSQTGDKKISLADLI
                     VLGGAAAVEQAARTAGYDVQVPFTPGRTDATQEWTDAESFAPLEPKADGFRNYRGKGNR
                     LPSEHLLVDRANLLNLSAPEMTVLVGGLRVLGANYQGSPLGVFTSVPGSLTNDFFVNLL
                     DTGTEWQPTSAAGEAFEGRDRATGEVKWTGSRVDLVFGSNSELRAVTEVYASDDAQEKF
                     MQDWIAAWDKVMNLDRYDLV"
     gene            complement(18320..19687)
                     /locus_tag="AMK32_RS31150"
                     /old_locus_tag="AMK32_30565"
     CDS             complement(18320..19687)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014671050.1"
                     /locus_tag="AMK32_RS31150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_30565"
                     /product="DNA-binding protein"
                     /protein_id="WP_241841284.1"
                     /transl_table=11
                     /translation="MSADPGGGSVLAAWERFVQGEDHIPGVRPLVAISWHRCREQYRVD
                     PHLTEAPVALPEFGHAPEHDVVFAELGFRAASVANEVGNLGCVVTVTDAAGRILAEWGD
                     QATLARAGGCNLAPWFCWSECAVGTNGMGTALEAHGPVPIRGAEHWCRAFHDWFSAGIA
                     VRDVVTTEPIAVLNICCWRSELPASAESWLAKAVTMTQHPLRRRARDSGAELVAAYTQA
                     RGRSGAALAALDTGGKVVIADDMASVLLGVPACTPAVDPTLRWNPGLPELIAAARYAAG
                     QAAHNPDWVGSTQIFAHLADEPTSISFRPVFSSGHLIGNLVSFGASDGAQLPQAEGSAH
                     PSVQPRRLIAIRGNRMVLLRLPEVSFAESMGNDVWLSTEQGRLRAASLSLDKLDNELAD
                     SGFLRVHRRYVVNLSRVREIERGLKGDLVLIMDGRVNDRVPVSRRNAPAVRRALDI"
     misc_feature    19866..19875
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            complement(20365..21285)
                     /locus_tag="AMK32_RS31160"
                     /old_locus_tag="AMK32_30575"
     CDS             complement(20365..21285)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012955.4"
                     /locus_tag="AMK32_RS31160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_30575"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_073898637.1"
                     /transl_table=11
                     /translation="MKVLIGRPSLRPYLSYQQRTAAHREGLSAHFLGTSSVLLSDGQTS
                     VLSDGFVTRPGMLRVGMGKIAPNRALVRSAIERLRVDTLAAVVCAHSHYDHALDAPVWA
                     LETGAELVGSESTANIGRGLGVPESSLRVVGDGDTATYGSFTLTFLDSVHSPGDHYPGT
                     VDQPLIPPARAGAWKTGTAHSVLVTHPNGRVLLQASANYRPGALRGHHADVVYLGVGTL
                     GKQPAEFLHTYWDEVVATTGAKRVILVHWDDFFLGLDRPLRPMPYLLDDLDTTMSRLLP
                     LARRDGVDVVLPVSWQTSAPLAGLA"
     misc_feature    22088..22103
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.28"
                     /tool="antismash"
ORIGIN
        1 ctggagacgc tcgacaaacg cggctcccgt ttctccggtc tgctcacgca gctgcgccgg
       61 gtggtctcgg ggctgtccgc cgaccgcagg cccatcgggg agtcgctggt gagcatcggc
      121 gacctcacgg acgtcacgtc ggggctgctg aaggacgcgc gtccaccgct gaaggacgac
      181 atcggcggga tcggcgatct caccggaacg ctgaacagga acgagaacac cgtggagggc
      241 gtcctgaagc ggctgccgaa caagctcgag aaactgacgg gcaccgcctc gtacggctcg
      301 tggttcaact tctacctctg cgacttcgac ggccggatcg tgctgccgaa gaccagacag
      361 gtgatcaccc cggacataca cgtggcgcga gcgaggtgcg gcggatgagc atgcgcgtca
      421 ggcggcgcac accccgcccc gagcccctgg tgaaggtgcg tgtcctgccg ccgaagctgc
      481 cgaagcttcc caggctgctg ccgagacgca caccccgccc cgagcccctg gtgaaggtgc
      541 gtgtcctgcc gccgaagctg ccgaagcttc ccaagctgct gccgagacgc acaccccgcc
      601 ccgagcccct ggtgaaggtc cgtgtcctgc cgccgaagct gccccggatc cggctccggc
      661 ggccacggct gaagcccttc cgcgagcgca atccggtcgt catcggcgcg gtcggcctcg
      721 ccgtcctcgc gctgctcacc gtcgccgcct tcaacgccga cagcctgccg ctgatcggcg
      781 gcggtgacac ctacagcgcg gccttctccg aggccggcgg actcaagccg ggcgacgagg
      841 tacggatcgc cggggtcaag gtcggcaagg tcgaggctgt cgacctggac ggcgaccacg
      901 tcaaggtggc cttcaaggtg aatggccgcc cggcattcgg taccgacacg ggtgcggcga
      961 tccgggtcaa gacgatcctc ggcgcgaagt acctggccct gtacccgaag gggcccggcc
     1021 ggctggaggc gggcagcgag atcccgctcg ggcggaccgt gtcggcctac gacgtcgtcc
     1081 aggccttcag cgacctgacg accaccaccg aagaggtcga caccgaccgg ctcgcgaagg
     1141 cgctggacac gatctccgtc accttccagg actctcccga ggaagtgcgg gcgtcgatca
     1201 aggggctgtc gcggatctcc cggaccgtcg ccgcccgtga caaggcactg cgagggctcc
     1261 tcgaccacgc gaacggagtc accaagatac tggccggtca cacgaaggac ttctccgcgc
     1321 tgatgaagga cggtgacgcc ctgttcaagg agatcgacaa acggcgcacg gcgatccaca
     1381 cgctgctcaa gagctccgca ctgctgggcg tcgagctgtc cggcctggtc gacgacaaca
     1441 gcaaggagat cggacccgcc ctgaagaacc tcaacacctt cgtgacgatg ctcgaacgca
     1501 accagagcag cctcgaccgc agcgtccgac tgctcgcccc ctacatacgg ctcttcagca
     1561 acaccctcgg caacgggcgc tggttcgact cctacatcca gaacctggtc gccgccccgg
     1621 tcacgccacg gacgggaggc acccgatgac ccgcagactc ctggccctct tccccgcgct
     1681 cgcgctcctc atcggccttg ccgtgatcct ctggccggcg gcccccggcc ccgtccgcgt
     1741 cacggcctac ttcccgcgca cagtcggcat ctaccccggc tccgacgtcc gcgtcctcgg
     1801 cgtccgcatc ggcgaggtca gggagatcac gccggagggc gaccgggtac gggtggagct
     1861 ggagtacgac cggggccgca ggatccccgc cgacgcacaa gccgccatcg tcaactcctc
     1921 cgtcgtcagc gaccgttacg tgcagctaat gccggtgtac cgcaagggcg cggagctgcg
     1981 ggacggagac gtcatccccg agtcgcgtac ggccgtcccc gtcgaactgg accggatctt
     2041 cgacagcctg cacaccaccg ccgaggcgct cggcccgaac ggcgccaaca aaaagggctc
     2101 gctgtcccgg ctgctcgggg tgagcgcgga caacctccag gggcagggcg agaacctcca
     2161 ccagacggtg cgagacctgt cccaggcggt caccacgctg tccgacgggc gcggcgacct
     2221 gttcgggact gtgcggaatc tgcaggtgtt cacggccgcg ctggcggcgg acgacaccag
     2281 cgtgcgctcg ttcaactccg acctcgccgt cgtggccggg caactcgccg gggaacgcaa
     2341 ggatctcgcg gccgcgctga aatacctggc cgtcgcgctc ggtgacgtgt ccggcttcgt
     2401 caagggcaac aagaaggcgc tgacctcgaa cgtgcggggc ctggccaagg tcaccaaggt
     2461 cctcgtcacc caacggaaag ctctggagga gctgttgacc gtcgccccca cgggcctgtc
     2521 gaacctgcag aacgcctacg accccgccgc cggcacgctc gacacccgca acaacccgca
     2581 gtcctcgcag gatccggctt ccgttctctg ctcgatcctg aaaacgaccg gcaaggacca
     2641 cgacgactgt gccgacctga agaaactctt cgactccctc cccgagcttc cgtcggctcc
     2701 cgcgtcgacg ggtacggtcg acaagaccct cggcggaata ctgaaggcac cggcatgagc
     2761 gcgcggcgca agggccggac ggcagcctgg gcggcggtcg gctccctgct cctgaccggc
     2821 tgcgagttca acggctggta cgacgtcccg ctccccggcg gcgccgcctc ggacggtcac
     2881 gcctaccacg tcacggtcga attccgggac gtcctggacc tcgtgccgca gtcggcggtc
     2941 aaggtcaacg acgtgaccgt cggcgcggtg gagaaggtgg aactggacgg ctggcacgcc
     3001 cgcgtgcggc tccgggtcgc cgactcggtg aagctgcccg gcaacgcgat cgccgatctg
     3061 aggcagacca gcatgctcgg cgagaagtac gtcgccctgt ccgcgccggc cggcacgcgg
     3121 cccctcggac ggctccgcga cggcgaccgc atcccgctgt cccgcagcgg ccgcaacccc
     3181 gaggtagagg aggtgctggc ggccctgtcc gcgctgctca acggcggcgg ggtggcccag
     3241 ctgaagacga tcaccgtcga gttgaacaag gccctcggcg gccgcgagga ccgggtcagg
     3301 tccctgctga agcagctcga cacgttcctc ggcggcctcg acgaccagcg ggcagagatc
     3361 gtacgcgcgc tgaaaggcgt cgaccggctc gcgaagcggc tgaagaagga gaagaagacg
     3421 atcgccctgg ccgtcgacac catgccaccc gccctgaagg ccctcgccga ccagcgaaag
     3481 gacctgacga agatgctcac cgccctgtcc gggctcggca agacggccac caaggtggtg
     3541 aacgcctccc acgacgacac cgtcgccgac ctgaaaaagc tccagcccat cctgcgaaag
     3601 ctgaacaagg cgggcgacga cctgcccgac tccctcgaga tcctcaccac gtacccgttc
     3661 ccgcgcaacg cgacggacgc cgtcaagggc gactacgtca acctgaagat caccgccgac
     3721 ctcgacctgg cgaacctcta cggcaacatc accggcaagc ccggcaaggg caggaagtcc
     3781 ccggcccccg gagcaccgca cctccccagc ctccccactc ccgcccccct cccgtccctc
     3841 ccctccgtcc cgtccctgcc gtccaccccg tccctgccgt cgaccccgcc cgtgccctcc
     3901 gcgcccccga cgccctccga cggcagcagc ctgctgtgcc cgccggtgtg caccgccgcc
     3961 tacagcaccc gtggcggcgc gcgtcgcctc ccgtcaggga tcgacctcgg ccttgccgag
     4021 ctgatgctga agggaatact gccgtgatca cccgtacggt caggacccaa ctgctcgcct
     4081 tcacggccgt caccgtcctt ggggtgtcgt acgtcggcgc ccggtacacg ggcctcgtgg
     4141 acgacgtcct gcaccgcggg tacaccgtgc gcgccgactt cgccgagtcc gggggcatct
     4201 tctccggcgc cgaggtcacc taccgggggg taccggtggg ccgcgtgggc gatctgcggc
     4261 tgaccgggtc cggggtctcg gtggcgctca agatcgagga cggcgcaagg atcccggccg
     4321 acacgctcgc ggtggtagcc gaccgttccg cggtgggcga gcagtacgtc gacctccaac
     4381 cgcggcggtc gggcgggccg tacctcacgg acggcagccc gatcccgcgc agccgcaccc
     4441 gcaccccgct ggcggtcacc gaccttgtcc tcagcctcga ccgactggtc aactcggtcg
     4501 gcaaggacga cctccgggtc accgtcgacg aactgggcaa ggcgttcgtc ggcaccgggc
     4561 cgaacctgag ccgactggtg gactccggcg actcgctggt ggagtcggcc tccgagtcgc
     4621 tgccccagac ggtctcgctg atcgaggact cccggaaggt gctcaagacc caggccgaca
     4681 agggctcggc catcaagtcg ttctcccgcg atctcgccac cctgacagcg cagttgaagt
     4741 cgagcgacgg cgacctgcgc cggctggtcg gcaacacgcc acccgccgcg cagcaggtcg
     4801 actccctgct gaggtccaca cggccgcacg tgccggtcct gctggccaac ctcatcagcg
     4861 gcggccagat caccctggcc cggctgcccg gcgtcgaaca agccctggtc acgctcccgc
     4921 tcacggtcgc gggcagctac acggtcatcc ccggtgacgg caccacccac ttcgggatga
     4981 ccgtgaacgc cgacgacccg cccgcgtgca cccagggcta cggcacccgg cggcgcgacc
     5041 ctgccgacac cagcacccgc ccggcgaaca ccgacgcgcg ctgcacggta ccgcgcggca
     5101 gcaagacctc ggtgcgtggt gcccagaacg cgcccggccc gaccaccggt cggtacagcg
     5161 ccgaccgggc cgccttcgtg gccccctacg acccggagac cggcaccgcg accggcccgg
     5221 acggaacacc cgtcgagatc ggctcgacgg gcggagaaaa gaccgtgttc ggaaaggagt
     5281 cgtggcaatg gctgctcgtg ggaccgatgg cgggagaggc gcacgcgtga ggctgctgtc
     5341 ggcggggctc gccgccgcga cggtgctgac gaccgtgccc tgtgtctggc taggggtgag
     5401 gctgtccgac cagcacgcgg tggaacagcg ccgccaggac atcctcgcgg cggcccgcca
     5461 gtcggcgctg aacttcacct cgctcgacta ccggcactac gaccgggaca gcggcaacgt
     5521 gctgaagggc gccaccggcg agttcaagaa ggagttcgcc gcgcagaccg cacaactgac
     5581 gaagctggtc gcgcagaaca agtcggtatc acaggggcag gtcctggaag cgggcatcgt
     5641 gcggtccgac gcgcgttcgg cgcgggtcct tgtcgtggcc gacagcaagg tgaccaacac
     5701 cggcgcgccc gagggccagg cgcgcaccta ccggctccag ctcgacctca cgcgcgtggc
     5761 cggacgctgg ctgacctccg atgtcacgtt cgtgggctga accgactgta cggccatcaa
     5821 tgaggagaga caccgtggca attcccacct cccgcacccg cgggaccggc tcaccggctc
     5881 ggcgcaccat gactgcggcc gcccgcgccg cggccaagcg cgccggacgg cccgtgcgcc
     5941 ccgagcgggg cgccgaccag gatgagcgaa ctccctccgg gcgcaccctg ctcgtcgagc
     6001 ccccgacgaa cggctgggag gacccgccgg agcccgagtc gttcgaggag gagccagagg
     6061 acggcgcgcg cccgcgcaag gccggccggc caggcgtgct caccgcagtg ctgggcgtcg
     6121 tcctcgtggc ggccctgatc acggtcgccg tactcgggtg gcagtacgtg caggagcggc
     6181 agacggagca ggcccgcggc gaggccgtgg cagccgcgcg tgaggcggcg ccggtcgtgc
     6241 tgtcgtacga ctaccggcac ctggaccggg acttctcccg ggcccacggc ctgctgaccg
     6301 gccacttccg cgaccagtac ggcaagacca cgaaggcggc ggtcgcgccg accgcgacga
     6361 agtaccacgg cgtggtgaaa gccaccgtgg ccacacccgc cgacggcagc gccccggcgg
     6421 tgtccgtcgt gtcggcaaca ccggaccggg ccgtcgtcct gctcttcgtc aaccaggtca
     6481 cccgaagcac tcaggtcccg cagccccggc tggacctcaa ccgggtgcgt atgacgctca
     6541 cccgcacctc cgacggctgg aaggtgagcg gcgtcgacgc cctctgacca ggcctccgta
     6601 agtgctgttg cgcagtcgcg caggggagtg gggcgcggcc cgaatggtat ggcgggcccg
     6661 cgcgccgttc ggcctccttc gagaagagtc cgttctctcg cgacggacgc cgcccgcctc
     6721 cccgtagagc agacgaaggc atcaccccta ccgccacaca tcaccaccct ccgtctgact
     6781 cgcgaaccca cgaggtacct gtggctctcc tctccacacg ccgtcttcac caccacccgc
     6841 gatcacgggg gcgtctcgcc gtcgggttgt cggcgctcat cgccgcaacc ctgccgagtg
     6901 cggccgctga cgccgccacc ccgccctccg gatcggtcag cgacaccgcg cccacgacca
     6961 catggagcgc cggtcccttc gccgtcccga acgtctccgg cactgccggg acggtgagct
     7021 gcgcgactgc gcaaccctgc gacgactacg ccctcaaggt gtcggtgccc gcggacttcg
     7081 acgccggtca cggcctgcgt atcgacgtca gatggccgga ctccgccgca gacttcgacc
     7141 tgtacgtcct cgacgcggac ggccgggagg tggccgcctc agcctcatcc ggcgaccccg
     7201 aggccgtgct gcttccggcg gtgtcggcgt cgtacaccgt gcgcgtggtg ccgtacgcgc
     7261 cgctcggcga cagcttcacc ggcaccgcaa gcctgatcac cgctccggtc gatccaccgc
     7321 cgagcacggc cacaccgccg acgtacgcga actcctgggc acccgatggc atcacggatg
     7381 cgcacaacgc cggtgaaccc tcgatcggcg tcgaccgtgc gagcggcgcc gcgatgttcc
     7441 aggcgtaaac ctcgacgctc aaggtcacct acgacagtgg cggtgcggcc acatggcagg
     7501 acaaaagcgc gatcgcggcc aacggctgcc cccagggcag cactaccagc ctcgacccga
     7561 tcctgttcac cgacccggtc acccaccgca ccttcgagtc gcagctcgcc ggcaagaccg
     7621 cgctgacctg ctacaccgac gacgacggtg aaacgtggac gccgacagcc ggctcgggca
     7681 tcaactccgg tgtggaccac cagaccatcg gcggtggccc cttcgccccg ggcggaccag
     7741 gcgccctcac gtcgtaccgg aatgccgtct actactgctc gcaggacatc gctgatgcct
     7801 cctgcgcggt cagccgggac ggcggcctga cgtacgggcc cgccgttgcc atgtactcgc
     7861 tgctggactg cggcggcctg cacggacatg tgaaggtcgc cccggacggc acggtgtacg
     7921 tgcccaacaa gggctgcggt gaccatcaag ccgtggccgt ctccgaggac aacgggctga
     7981 cgtggaccgt ccgcaagaac ccgtccagca cggccggtga ctcggacccg agcgtgggga
     8041 tcggagccgg cgggactgtc tacatgggct accagaacag cgacggcacg ccccgtatcg
     8101 ccgtcagcca cgacaagggc aagacgtggc tgtacgacca gaacgtcggc gcggccctcg
     8161 gcatcgagaa cgtcgtcttc cccaccgtga ccgcgggcga cgacaaccgc gccgccttcg
     8221 ccttcctcgg caccaccacg ggcggcaact accaggaccc ggccttcccg ggagtgtggc
     8281 acctgtacgt ggccaccacc tatgacggcg gccagtcctg ggtgacggcc gacgccaccc
     8341 ccaccgaccc cgtccagagg ggttcgatct gcacgggcgg taccacctgt ggcaaggacc
     8401 gcaatctcct ggacttcgtc gacgtcacca ccgacgccca gggccgcgtg ctcgccgcct
     8461 acgccgacgg ctgcaccggc acctgcgcga ccggaggagc gcagaactac gacgcgctgg
     8521 catccatcgc ccgccagtcc tccggcaaca cgctctacgg agcgtacgac gccgtggtca
     8581 gcggcaagca caagaagccc ggaggaagcc actagatgag accctcgctc tcggctgccg
     8641 tactggtagg agccgtcctc agcctggccg cggtcaccgg atgctcggcg gcgggcaacc
     8701 acgccgagcg cccgggggcg acgcaggacc cggtgaagcg ggcaaccgag gcgccggccg
     8761 ggaataaggc cggcgccgcg cccgacggct gtcccacggc agcctcgctg cctctcccca
     8821 aggactttcc cgcgaacctg ccggtgcccg acggcgcggt cgtgacctcg gtggagcacc
     8881 gcaccggcgg ccgactcgtc gtcaccaccg tcgtacgggg cggcttcgac accaccctgg
     8941 cgttcctgca cacgcggctg cccaaggccg gctacatccc tgaggagggc gaggtggagg
     9001 aggacgacgc cgagtcgaac ttcttcaccg cgaccgtccg gggccgctgg gccctgcgga
     9061 agatgcccga ctgtggggga ggggtgtacc tgacgtacct gacggctgac gtctcctgaa
     9121 cccggcccgg ccgagtcctc cagtccaagg cgacgcacag ttgggtcgga ccgtcagcca
     9181 agcgagcatc acgccctctg tcaggggcgg acgggccggg tcgccgttcc agcgtccgtt
     9241 tctgctattc ggcgtcgtac tcggctaatt cgccccggaa tttggctttc caggtttatc
     9301 agtcgaccgg gctgagatac tctgtagaac atggtggagg tgagccgagg cggagtcgca
     9361 ttcgccgacg ccggtcgtca tcgggcagtg gcgtcgccat gatctgggag atactggtcc
     9421 tgggttttgt actcagtctc gataatttcc gggtatcgat cgcgctcggc acggtcccat
     9481 ttggtttgaa gcgcgcggtg caggtcgcgc tgaccttcgg actgtgggac gcggttatgc
     9541 ctctggtcgg gctgttgatc ggtcaccaga tcggggaatc cgtaggggac gtcgccgatg
     9601 tggtgggcgc gggcgcgctc ggcgggtacg gcctctatct cgtcatctcg tcccttcgga
     9661 accccgagcc ggacgagttg gaccacccgt gggcgttgtt cggcattccg ttgacgctga
     9721 gcctggacaa tttgttcgca ggtgcgagcc taggagtcct tggtatctcg ccgtggttct
     9781 cggccgccac tttcggcgtg atgacagcag tgttgtcgct ggtcggtctg cagctcgggc
     9841 gggccgcggc gcggctcatc cggattcgct cggacctgtt gagtggggtc accttgatca
     9901 ttgccgcagc ggcgctgccg ttgtggttcg gcaactgacc cgctccgccg ggaggcggtc
     9961 ggcctgcaaa ggggcaacgg aaaggccacc gacctgcggg tcagccctgg tggcctcgac
    10021 cgcctcggcg accctgtggc ggggcgatag ccggcagccc gggccggtgc gggcggggga
    10081 tcagcggagg atcgtcggac cgcgagtcgg cgttggcggc ttcgaccgcc cggacgacga
    10141 ggtcgtggtc gggggacagg tagcagaccg ggtcggtgcg ggccgcgtca ccggtgagca
    10201 ggaacgcctg gcagcggcac ccaccgaagt ccaactcccg ccggtagcag ctccggcagg
    10261 gctccggcat ccagtcggtc ccccggaacg cggtcattat gggggactcg gcccagatcc
    10321 gctccagcgg ctcgtcccgg acgctggccc gcggcagcgg caggggttgg gcggccggac
    10381 agggcaggac gtcaccgttc ggcgtcacgg tcagctgccg ggaggcccag ccgcccatgc
    10441 agggtttcgg gaagcggctg tagtagtcgg ggatgacgta gatgacgtcc atgcggtccc
    10501 gcagccgctt gcgggctgcc cgcacgacga cctcggccgc ctcgagctgg gcccggctcg
    10561 gcagcagcgc gtctcggttt cgccacgccc atccgtagta ctgggtgttg gccagctcca
    10621 gccggtcggc gcccacgtct tcggccagtg cgagcacgtc ggcgacgcgg tcgatgttgt
    10681 gccggtgcag caccacgttc atggtgagcg gccagcccag ttccttgacg acgcccatcg
    10741 cctcgatctt gcgttggaag gagggggtgc cggcgatgcg gtcggacacg gtcggctcgt
    10801 cggcttggat gctgatctga acgtggtcca ggccggcggc ccgtagctcc tcggctttcg
    10861 aacgcgagag cccgagggcg ctggtaatga ggttggtata gaggcccacg tcgtgggcgt
    10921 gcgccacgat ctcccccagg tcgcgccgca gcagtggctc ccctccggac aggtgacatt
    10981 ggagaacgcc cagttcgctt gcctcggcca gcacgcgccg ccactcgtcg gtggtcagct
    11041 cgtcctggta gccggccatg ttcagcgggt tggagcagta cgggcaggca agcggacacc
    11101 ggtaggtgag ctcggcgagc aatccgaacg ggctatccat cggtgagctc cagccagcgc
    11161 cgggagacga gctgggtcaa gaactgtcgc acctcgtcct cggagacggc ctggtagcgc
    11221 gcgcccagct cggtgacgat ctcggtcacg gtgtgccgcc cgtcgcacaa ctcgatgaca
    11281 gccccgccgc tgccgttcag aaccactacc gtctcggggt gcagcagaat ccgacgcctc
    11341 ctggtccggc agaaggccag cctgacatgg cgcggcaacc ggggccggtc aaagtccgac
    11401 acttcgacgc cgggtcgggt cctggtaccg gtctgggtcg ttccggtagg gggcgggtcc
    11461 atggtcactc cgggtaggcc tggtcgattg cgtccatcag gctccacagg acgtcgcact
    11521 tgaacgacag cgcgtcgatg gcacgggcct gggactcggc ggagaggcag tgcgcggtga
    11581 ccacctcgag ggcgtgttcg cagtcgcggg gtgcctgctc caggcgggag cggaagtagg
    11641 caaggccctc ggggtcgatc cacgggtacc accgttcgaa ggcctgcagc cgcgctgcca
    11701 tcaggtcggg cgcgaacagc tccgtgagcg aggacgcgac tgcctccacc cacgggcggg
    11761 cccgggtgaa gttcacgtag gcgtcgacgg cgaaccgcgc accgggtacc aggtgccggt
    11821 ggtcgcggat ctcctcgcgg gtcagccccg tggcttcgcc gaggcgcagc catgcctcga
    11881 tgccgccctc gccgtcggcg gtaccgtcgt ggtcgatgat ccgtcggatc cagcggcggc
    11941 ggacctcgag gtcggggcag ttggacagga tcgcggcgtc cttgcggggg atgttctcct
    12001 ggtagtagaa gcgattggcg acccagccac ggatctgccg ggggctcagc ctgccggcgt
    12061 tcatccggac gtggaacggg tgatggtcgt ggtattgccg cgagtgggcc cgcaacgtct
    12121 cgacgaagcc gtcggcgccg gttctcgtag ttgtcgtcgt cacggctcta cacctggacc
    12181 tcgaggccgt ccatggccac ttgcatgccg ctctcctcta cggtacgccg ctcgggtgcg
    12241 tcctccagga ggatggggtt ggtgttgttc atgtgcacga agatcgtccg tcccgcaccg
    12301 agcgacggga gctgcgccag gctgccgtcc gggccgtcga tgggcaggtg gcccatctcc
    12361 cgggacgtct tgccggacag cccgagccgt acgagttcgt cgtcgcggta gcaggtcccg
    12421 tcgatcaaca ggcatgcgca gtcctcgatt tccgcgcgta gcgccggcgt cagcgattgc
    12481 accccgggca ggtacaccaa tgtcctcccg ctgcgctggt cggtcagccg gtagcccacg
    12541 acgcgaccat ggtcgacccc ggctccgaac cgggcgcgtt tggtggtggg cacgtcgaaa
    12601 acccggcagg acagcccgtc tgccaggtcg aggtcggctc cgggggtcgc tgcatgccac
    12661 tcgaccgggc agtagcgctc gagcgtgcgc agaatccccg agccgtcgca cagtgtcttg
    12721 tgcgtggcgg gtgtggtgta cagccgcagg gcgcgggcct cgcgcaagag aagcaggccg
    12781 agcgtgtggt ccagctcgga gtcggtgagc agcgccgcct ccagcggcgt cgtccggtcg
    12841 ccgcgggggt gcagggcggg gaaggcctcg atctgggtgc ggacgtcggg cgaggcgttg
    12901 atgaggaacc accggcggtg gtcggcactg accgcgaccg acgactgggt gcgcgcgagg
    12961 ccggtccggg agcggaccgc ggcgcacacc gggcagccgc agttccactg cggggagccg
    13021 ccccccgccg ccgaacccag cacgcgcagc aacacgccag cactccgttc gtcgaagtcc
    13081 ggtccgtcgc cggcacggcc gtccggggcc gtgccgggct gtccgagggc gccggatcag
    13141 gtccgacgcc gccccggatc cgctactcct ccaactgatc gaggtacatg gtcacctcgg
    13201 ccgcgacagc gatctcgtcg aactcgggcg tctcccacgc ggcgagttga gactgtgtct
    13261 cgggggtctc ccacacagtg agctggggtt ccatcgattc acctcctttc tgcccgaatg
    13321 cggcaggctg cggtcatgcg ctacgccgct tcagggaggg cgaagacgat caaggcgctt
    13381 ccgtggcccg cgccgagcat gccggggagg aatccctcgg cccagccgcc ccatccgacc
    13441 ggcacggcga tgtactgcct gttgtcgacc atgtaggtgg tcgggctgct gtggtggccg
    13501 cttccgcatt ggaactgcca caacagttca ccggtgcggg cgtcgagtgc gttgaactcg
    13561 ccggaggctt cgccggcgaa caccaggtcg ccgccggtgg ccagcaccga ggcgcacatg
    13621 ggaagttcgt tgcgccagcg ccacttctcc tcgccgcctg cgtcgaacgc gctgatggac
    13681 cctgccatgt cctcgatgtc cacctgaacg cccgcgcccc agtacggaat gctttccttg
    13741 aactctcggc gtcgccgcgt ggcggtggcg ccggtgtctt ggactgggac gtagaagagt
    13801 tcggtcttcg ggctgtaggc cgcgtgggtc cattccttgg cgccggccgg acccgggtag
    13861 aagtggactg gttctccctc cttgtccggg tacaccttgg ctgtcacctg gccgtccctc
    13921 gtgatcgccc cccacgtgat ccggtccacg aacggggtga tctgtactct ttcgccgttc
    13981 gtgcggtcga gtacgaagaa gtagccgttc ttgtcgaagt gcccgagcag tttgcgcccg
    14041 tcgtgctcga acaggatgca ctcggcgatg ctgtcgtagt cccacaagtc gtgcggggtg
    14101 cactggtagt gccagcggat ctgaccgctg tccacgtcga cggcgatgat gctgtccgtg
    14161 aagaggttgt cgccctcgcg gacacctccg tcgaagtcgg gtgccgggtt gccggtgccg
    14221 acgtacagca ggttcgtctc cgggtcgaag gtgccggtga cccagcagtt cgccccgccc
    14281 cgtgcccagg cctcgccgtc ggcgggccag gtctccgagc cgggctcccc gggcttcggc
    14341 acggtgtagc agcgccattg gtgctcgccg gtctcgaggt cgaacgcgtc gaggtggccg
    14401 cgcacgccga actcgccgcc ggaacttccc acgatgacca tggacttcac gatcagcggg
    14461 gcgaccgtgg cgctctcccc ggctcggacg tctccgtagg tcttgtccca gacccgcttg
    14521 ccggtggtgg cgtcgagcgc gagcacacga gcgttcgccg tgacgaagaa gaccttcccc
    14581 tgagccacgg cgaccccacg gttcacgttc ccgcagcaca aggacacgtc gaaggggacc
    14641 gcatgcttgt accgccagat ctccacaccc gtctttgcgt caagggccca gacccagccg
    14701 tcccagccgg agaggaacat gaccccgtcg acgacgatcg gggccgcctc gaacgaatag
    14761 gtcgacgcgc ccgcgatcag gccggtggtg ccggcctgga atacccaggc ggggaccatg
    14821 cgcttgacgt tctctgtgtt gatctggtcc agcgggctgt accgctgccc gttgtaggcg
    14881 ccgtagtagg tgagccagtt ctggggttcc tcgcgggcgt tgagtatgcg ttcgtagtcg
    14941 acgccggcca ctaccggcgg cgcgacctcc ccgcccgcga ccttgccgct cagggctccc
    15001 tgatcgacag cctcacccgc gtcaacgtag tcggcgtagt cgacggtcat ttcctccacc
    15061 tcctacttgt tcctacggcc gcggctgttc gggacggtcg aggcgagcct ctggcggagc
    15121 gtcccccagg acgacgatgg ccccggtcag cccccgcccc tcgtcgttgc cggtgggcga
    15181 ggcgtaccag tagtagcccg gcccgtcgag gttgaggtgc gcgtgtccgt gcgaatggtt
    15241 caccaaccag atgaatttcc ggtcgccgtt gctcggcagg agcgcgcagt gcgtgttctg
    15301 gtcgtcgttg acgagctcca gctcgatatc gcctccgtgg ggcatgacca gaatggaggg
    15361 atcgaaggtc agctcgtccg ggtggatgcg aattgtggcc tccatatgac catccgattt
    15421 ctcggtggcc tggccaatgc ttccggttcc cagcacttgc cccagcgctg ctttgttctg
    15481 tgcggccaac ccgatcttgt ccagcaggtc ggctcgctcc tgcgcggtcg tcataggggc
    15541 ttcactcccc tcatctcgaa tctctgcgtc caattcgcat agatcgcgct gaaggagtcc
    15601 gaatttagag cccgctatgc caagtgaatc agaccgagaa gggtgagaaa tttgtactca
    15661 aaaggcacgc tacgccggat ggatcacacc gacaagggtg agctccagtt cgggcgactc
    15721 atgccgctcg tccgcgacca actaccgttc gtcctcggat agccgccgtt gggaggagtc
    15781 ggctgcactg cactgcactg caccgcgtca cgccgtgacg cggccgatct ggcggcctgc
    15841 tcggtcttcg cgcagtaggc ggcgcgggct acctcgtcga tccgttgctc gtgttcggcg
    15901 cgcagcccgg tgcggaagtc gaagccctcg cgcaggagtg ttcccacctg cgccggcaga
    15961 acccggtctg atcgcgcgcc tcgttctcct cgcccctgga acccgcccca taagacagcc
    16021 actaaacctc gatggaggat catacgaggt cgtaccgatc aaggttcatg accttgtccc
    16081 acgcggcgat ccagtcctgc atgaacttct cctgtgcatc gtcgctcgcg tagacctccg
    16141 tgacggcgcg cagctcggaa ttcgagccga agacgaggtc gacccggcta ccggtccact
    16201 tgacctcgcc ggtggcgcgg tcgcgaccct cgaaggcttc cccggccgcg gatgtcggct
    16261 gccattccgt gcccgtgtcg agcagattca cgaagaagtc gttggtgagc gacccgggca
    16321 ccgaggtgaa gacgcccagc ggcgacccct ggtagttggc gcccagcacc cgcaggccac
    16381 ccacaaggac ggtcatctcg ggcgcgctca ggttcagcag gttcgcgcgg tcgaccagca
    16441 ggtgctccga cggcagccgg ttgcccttgc cccggtagtt gcggaacccg tccgctttcg
    16501 gctcgagcgg ggcgaaggac tccgcatcgg tccactcctg cgtggcgtcc gtgcgtcccg
    16561 gagtgaacgg gacttgaacg tcgtagccgg cggtcctggc cgcctgttcc acggcggcag
    16621 ctccgccgag cacgatgagg tcggccagcg agatcttctt gtccccggtc tgggagctgt
    16681 tgaaggactc ctgaatcccc tccagggtgt gcagcacctg tgccagcttg tcggggtcat
    16741 tgacctccca gttccgctgc ggctcgaggc ggatgcgcgc gccgttcgcc ccgccacgtt
    16801 tgtcgctgat gcggaacgtc gaggccgacg cccatgcggt cgaaacgagc tgggagaccg
    16861 acagcccgga ggcgagtatg cggctcttga gcgcggcgat gtccgccgcc ccgacgagct
    16921 cgtggtcgag cgcggggacc gggtcctgcc agcgcagcgt ttcccggggc accagggggc
    16981 cgagatagcg ctggatcggg cccatgtcga ggtgcgtcag cttgaaccac acccgggcga
    17041 acgcgtccgc gagctggtcg gggttctcca ggaagcgccg agagatcggc tcgtagaccg
    17101 ggtccgatcg cagcgcgagg tccgtcgtca gaatcgtcgg ggcatgtgcc gtcgacgggt
    17161 tgtgggcgtc gggcacggtg cgggccccgc cgccgtccct cgggatccat tgccacagac
    17221 cggcggggct cagctccagg tcccactcgt agccgaacag ggtctcgaag aagctgttgt
    17281 cccatctcgt cggggtggga gtccacgtac cctcaagccc gctggagatg gtgtccctgc
    17341 cctttccggt gccgtagctg ctcttccagc ccaggccctg ctcttcgagg ggcgcgccct
    17401 cgggttcggg gccgaggtac gcctccgggt cggccgcgcc gtgggtcttg ccgaacgtgt
    17461 ggccgcccgc gatcagcgcg acggtctcct cgtcgttcat ccccatgcgc cggaacgtct
    17521 cacggatgtc ccgggccgcg gtgagcgggt ccgggacggt gttcggtccc tccgggttga
    17581 cgtagatcag gcccatctgg accgcggcga gagggtgctc cagctcccgg acgccgacgt
    17641 ggcgttcgtc gccgagccag gtgcgctcgc gaccccagaa gatcccttcg tcgggtcccc
    17701 agacctccgc ccggccaccg gcgtagccga aggtcctgaa gcccatcgtc tccagggcac
    17761 ggttgcccgc gaagatcatc aggtctgccc acgaaatctt gcggccgtac ttcttcttcg
    17821 tcggccagag cagccggcgc gccttgtcga ggttgcgatt gtccggccag ctgttcagcg
    17881 gcgcgaaacg ctgcaggctg gtgcccgcgc caccgcggcc gtcgtcgatg cggtacgtcc
    17941 cggcgcaatg ccacaccatg cggatcacga gcggcccgta gtggccgaag tcggccggcc
    18001 accactcctg ggacgtcgtc agcgcctcgt cgacgtcccg cgcaagggcg tcgaggtcga
    18061 gcgtccggaa ctccgcggcg tagtcgaagt cctcgcccat ggggtcggca acgccgcggt
    18121 gtgtccggag gatcgtcagg tcgagctggt tcggccacca gtcgcggttg ctcgcgcccc
    18181 cgatcggacg accgcggtgc tcggccgaga cagagaggcc aaggccgccc gcgctcccag
    18241 gtttcatctc gccgctcatg gcgtcccgac tgtcagacac gggaacttcc ttccggaccc
    18301 ataggccgtg ccggcctact cagatgtcca gcgcgcgacg cacggccggc gcgttccgcc
    18361 gggagaccgg caccctgtcg ttcacccggc cgtccatgat caaaacgagg tcgcccttta
    18421 gcccccgctc gatctcccgg acgcggctga ggttgaccac ataccggcgg tgcacccgca
    18481 ggaagccgga atccgccagc tcattgtcga gcttgtccag gctcagagag gcggcccgca
    18541 gccgcccctg ttcggtggag agccacacgt cgtttcccat cgattcagcg aaggagactt
    18601 ccggcagccg cagcagcacc atccggttgc cgcgtatcgc gatcagtcga cgcggctgca
    18661 ccgacgggtg cgcggaaccc tccgcctgcg gcaactgtgc cccgtcggag gcaccgaacg
    18721 agaccaggtt gccaatcagg tgtccggacg agaagacggg tcggaaactg atcgatgtcg
    18781 gctcgtcggc gagatgggca aatatctgcg tcgagccgac ccagtcaggg ttgtgagccg
    18841 cctggccggc ggcataccgg gcggccgcga tcaattccgg cagcccgggg ttccatcgca
    18901 gtgtggggtc gaccgccggg gtacatgccg ggacgccgag gagcacgctt gccatgtcgt
    18961 cggcgatcac caccttgccc ccggtgtcca gcgcggcgag cgccgcaccg gagcgtcccc
    19021 tggcctgggt gtaggcagcg accagctcgg cgccactatc cctggcgcgc ctcctcagcg
    19081 ggtgctgggt catggtgacc gccttcgcca gccagctttc cgcggacgca ggaagctcgc
    19141 tgcgccagca gcagatgttc aggaccgcga tcggttccgt ggtcaccacg tcacgcaccg
    19201 cgatacccgc gctgaaccaa tcgtggaacg cccggcacca gtgctccgcg ccccggatcg
    19261 gtaccgggcc gtgcgcctcg agcgccgtac ccatgccgtt cgtacccacc gcgcactcgg
    19321 accagcagaa ccagggcgcc agattgcagc cgccggctct ggcgagcgtg gcttgatcac
    19381 cccactcggc gagtatgcgg ccggcggcat cagtgacggt gacgacgcaa ccgaggttgc
    19441 ccacttcatt cgccacggag gcggcacgga agcccaactc ggcgaacacg acatcgtgct
    19501 cgggggcatg gccgaactcc ggaagggcta ccggagcctc tgtgaggtga ggatcgaccc
    19561 ggtactgctc gcggcagcgg tgccaggaga tcgccacgag aggccggaca cccgggatgt
    19621 gatcctcgcc ctgtacgaac cgctcccacg ccgcgagcac gctgccgccg cccgggtccg
    19681 ccgacatggg ctcaagccga tgtgcactcc tcatggttca gaaccgcctc tggtccatcc
    19741 ccaacgcgct gcgtcgcgcg ccctactgct tcgtcacgtt ccaggctgtg tcacagacct
    19801 ccacctccca ccctaggtac ggttgtcggg ctgcgcacgt cccttccggg ccgcgtgggc
    19861 acgtcgaagg cggccacgcc gaccacacgc acgggtctct tgacctgcct gcccacggtc
    19921 atggcgacca tgatccggct ggctcagatg cctgcgtcga cagcgaagac gtcgaggccc
    19981 gcggcgtggg ccggcttcca cgccgcgtgc acagcggctg cgctcgctgc ctgctcgggc
    20041 gtgtggctgt gggcgatgag ctagagagat cgccaggacg gcgagccttt cccgcaggtt
    20101 cctggacgtc cggcggtcgg acagccttgc gcaggccggc ctcggtctca agagcaagcg
    20161 cccggtcgct gggagccggc tcccacacct ggtcatggat ctgctgcccg gcttccgtcc
    20221 gccaaccggt cgggccgctt cactcgccag cgcacctcag ccggcgcgcc caaccccact
    20281 gccgcacctt cagtgagtgg ctcgtctcgc atcgctggcc gggtaatcgc cgcgctacgc
    20341 ggattccagg ggatgcgggc gagttcatgc aagaccggcg aggggcgcgc tggtctgcca
    20401 ggagacgggc aggacaacat cgactccgtc acggcgggcc aggggcagca gtcggctcat
    20461 ggtggtgtcg aggtcgtcga gcaggtaggg catggggcgt agtggccggt cgaggccgag
    20521 gaagaagtcg tcccagtgca ccaggatgac ccgcttggcc ccggtcgtgg ccacgacctc
    20581 gtcccaatag gtgtgcagga actcggcggg ctgtttgccc agtgtgccga cgcctaggta
    20641 gacgacgtcg gcgtggtgac cgcgcagcgc gccgggccgg tagttggcgc tggcttgcag
    20701 gagtacacgg ccgttggggt gggtgaccag cacggagtgg gcggtgccgg tcttccaggc
    20761 accggcgcgg gccggcggga tcaagggctg atcgacggtg ccggggtagt ggtcgcccgg
    20821 gctgtgcacg gagtccagga aggtcagcgt gaagctgccg tacgtcgcgg tgtcgccgtc
    20881 gccgaccacc cgcaaggacg actcggggac cccgaggccg cgcccgatgt tggcggtgga
    20941 ctccgacccg accagctctg caccggtctc cagcgcccac accggtgcgt cgagggcgtg
    21001 gtcgtagtgg gaatgcgcgc acaccacggc ggccagggtg tccacccgca ggcgctcgat
    21061 ggcggaacgg accagcgctc ggttcggggc gatcttgccc atgcctactc gcagcatccc
    21121 cgggcgggtg acgaacccgt cgctgagcac cgatgtctgc ccgtccgaca gcagcactga
    21181 actcgtgccc aggaaatgag cgctcagccc ctcacggtgc gctgcagtgc gctgctggta
    21241 agacaggtag ggccgcagac tgggacgacc gatcagcacc ttcatacgag catcctcgaa
    21301 ccccaggggc aggagcggcc acctccggac ctcgtgtgcc ctctcacaac cggtccatcc
    21361 tgcaaagccc gttcagcgcg cgcccgtgag ccgccgcggg gcccgggctt cctctcagca
    21421 ggcgtgacac cgtgccgcac cgcttcccgc gagcaggtcg aggtctccgg aaggccgttt
    21481 tcacgaaccg gggttcaggc cctccgagcg ccgctgcgca tgcccgggcg tcgggtccag
    21541 atacacccgg cacaccgccg ggaacgcctc gtgcagtcgc tgctcggccc gctcacaggc
    21601 ccactcgacc tcggcggcgg tcgacaggtc acggaagtcc accttggccg ccaccagggc
    21661 ctcccccggt gcctgcacca gagtcgtcag ctccagtacc gcctcgatgt gctccacctg
    21721 caggagttcc gcccggatcc gctcccgcac cggccggggc agcggccgcc cgatgagaag
    21781 ctccacgttc gaccggccga gcacccaggc gacgtacagc agcagcacgc cgatggacag
    21841 ggaggctatg ccgtcccaga ccccggatcc cgtgagctgc ccgcccagca ggccgcccgc
    21901 cgccagcacc aggccgatca gcgcagccga gtcctccaga accaccgcct tcacggcggt
    21961 gtcgggcgtg tgccgcagat agagccggaa gggcatcccg cggcggtccg cgtcaccgcg
    22021 cgcctggcgc accccggtcc gcagcgagaa gccctccagc gcgaaggcga tcgcgaggac
    22081 gatgtacgac acccgcgggt caccgagcgt ctcgcccctg gtcagggtgt ggatgccgtc
    22141 gtagagggag aagaccgcgc cgc
//
