LOCUS       NZ_LIWA01000006        22163 bp    DNA     linear   CON 28-MAR-2024
DEFINITION  Streptomyces sp. CB01883 scaffold6, whole genome shotgun sequence.
ACCESSION   NZ_LIWA01000006
VERSION     NZ_LIWA01000006.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CB01883
  ORGANISM  Streptomyces sp. CB01883
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 652158)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 652158)
  AUTHORS   Yan,X., Ge,H., Hindra,F., Yang,D., Huang,T., Crnovcic,I. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-AUG-2015) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2014
            Assembly Method                   :: CLC Genomics Workbench v. 7.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905855.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:34:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,089
            CDSs (total)                      :: 8,009
            Genes (coding)                    :: 7,788
            CDSs (with protein)               :: 7,788
            Genes (RNA)                       :: 80
            rRNAs                             :: 3, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 221
            CDSs (without protein)            :: 221
            Pseudo Genes (ambiguous residues) :: 0 of 221
            Pseudo Genes (frameshifted)       :: 85 of 221
            Pseudo Genes (incomplete)         :: 169 of 221
            Pseudo Genes (internal stop)      :: 25 of 221
            Pseudo Genes (multiple problems)  :: 50 of 221
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:33:31
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 242352
            Orig. end                         :: 264515
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LIWA01000006.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22163
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="3"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22163
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22163
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12163](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12163)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            541..1791
                     /locus_tag="AMK32_RS27325"
                     /old_locus_tag="AMK32_26825"
     CDS             541..1791
                     /GO_function="GO:0004181 - metallocarboxypeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016643570.1"
                     /locus_tag="AMK32_RS27325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_26825"
                     /product="M14 family zinc carboxypeptidase"
                     /protein_id="WP_073897357.1"
                     /transl_table=11
                     /translation="MSLLPELRYPSVPELVAHARVLAAQEPGLCTLRQVGSSRAGRPLH
                     LLSVGHAERAVLVVAGAHANEPAGGSTLQAVAERVLAERELRSGTSWHFLLCADPDGAS
                     LHVTPAPRSLFDYHLGFYRPTGAEQPEWSPSVLPPDRLPPETVALTGVIDELRPYLQVT
                     LHGTDLGGSWVQLTRDVPGLAEPFAKSAAELHIPVETGASDAAGWPASGPGVHVMPGPE
                     SGVAYPSMPDDARHSTWYHAHRHGGLTAVVEVPMWASDLVDDPAPHPAPAAAMRRLARR
                     LLRDSLEVEGVLAEALPRLDGADGPLLRAARWALELIPGLAEDWVHTPPAATTMAYVGS
                     VDAFGRRLPLRAAAMLLRVLREADDSAAPRLEQLVALWCDAFATRFRARWVPLENQVEH
                     QSRTVLVAAQQAREQVG"
     gene            complement(1837..2250)
                     /locus_tag="AMK32_RS27330"
                     /old_locus_tag="AMK32_26830"
     CDS             complement(1837..2250)
                     /GO_function="GO:0004867 - serine-type endopeptidase
                     inhibitor activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019071457.1"
                     /locus_tag="AMK32_RS27330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_26830"
                     /product="SSI family serine proteinase inhibitor"
                     /protein_id="WP_073897359.1"
                     /transl_table=11
                     /translation="MTYITRATAAAGALLAAAGLLAAGPARAAAGDTPTGNWLYLSVTK
                     GDGRPGGPRGGLLLCDPPLGHARAAEACAELGASGGDIDRIPARNVFCPMIFAPVTLHA
                     RGLWDGRSVDFRQTYTSRCVMEARTGAVLAFDD"
     misc_feature    2337..2346
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            complement(2373..2924)
                     /locus_tag="AMK32_RS27335"
                     /old_locus_tag="AMK32_26835"
     CDS             complement(2373..2924)
                     /GO_function="GO:0051219 - phosphoprotein binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675706.1"
                     /locus_tag="AMK32_RS27335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_26835"
                     /product="DUF1707 and FHA domain-containing protein"
                     /protein_id="WP_073897361.1"
                     /transl_table=11
                     /translation="MTSSFEFSTYPARLSDAERDKALQALRDGVAVGRLSHDTFVRRME
                     LALAARRSDELAVLVADLPRDNRFSRMVLGSVEAVSGFTVRLRRAWQAERLPKLLLPHP
                     EHTHPLRIGRDPASGLRLNHETVSRVHAELSRRGGMWILRDLGSTNGTTVNGRRVTGSV
                     VVREGDQVSFGRMAFRLATA"
     misc_feature    2953..2967
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.42"
                     /tool="antismash"
     gene            3101..4846
                     /gene="treZ"
                     /locus_tag="AMK32_RS27340"
                     /old_locus_tag="AMK32_26840"
     CDS             3101..4846
                     /EC_number="3.2.1.141"
                     /GO_function="GO:0033942 -
                     4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0005992 - trehalose biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="treZ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1297: Pullulanase, type I"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675705.1"
                     /locus_tag="AMK32_RS27340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_26840"
                     /product="malto-oligosyltrehalose trehalohydrolase"
                     /protein_id="WP_073897363.1"
                     /sec_met_domain="Alpha-amylase (E-value: 2.2e-12, bitscore:
                     42.1, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQFEVWAPQADRVTLQCEGGTRALARDPERAGWWTGEAEAADGAR
                     YGFALDDGPVLPDPRSRRQPDGPDGLSAVVDHGGYTWRSRWAGRGLPGAVLYELHVGTY
                     TREGTLDAAAARLEHLVELGVTHVELMPLCPFPGRHGWGYEGVSLWAVHEPYGGPEALK
                     RFVDRAHELGLGVVLDVVHNHLGPSGNHLPSFGPYFTDTHHTPWGSAVNLDAPGSDEVR
                     AFLLESALAWLRDYRVDGLRLDAVHALYDTRACHFLEELSAAVDGLAEEVGRPLFLIAE
                     SDLNDPRLITPRAENGLGLHAQWNDDFHHALRTTLTGESQGYYADFARAPFAALAKTLT
                     GGYFHDGTYSSFRGRRHGRPLDRARVAGHRLLGYSQTHDQVGNRAQGDRLAAVLSPGLL
                     ACAAALTLTAPFTPMLFMGEEWAAGTPWQFFTDHTDPELAEAVRRGRRREFAEHGWAEE
                     DVPDPQDPATRERSCLDWSEPEREPHARVLAWYRRLIALRHEQPDLTDPDLADTKVAYD
                     DEARWLAFRRGDVRVAVNLGKEAAAIPLGTGRTEVLAAWEPVEAPGPDGLLQVPGESCV
                     VLTQP"
     gene            complement(4884..5819)
                     /locus_tag="AMK32_RS27345"
                     /old_locus_tag="AMK32_26845"
     CDS             complement(4884..5819)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675704.1"
                     /locus_tag="AMK32_RS27345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_26845"
                     /product="phosphotransferase"
                     /protein_id="WP_073897365.1"
                     /sec_met_domain="APH (E-value: 9.3e-18, bitscore: 59.9,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQAPTPTADTVRRLVRSLLDEGTGGTGGPDVRPVREGHAHTWWV
                     GTRHVLRLAPDREASARRRRELRLRDLVRPHVPVAVPTSVAHGDWAPGLAYTLDTLVPG
                     GTADEHDVSAVGEADLAGLLTGLRAVPQRQAETAGVPRTAPRSLEALRRMAVHAAERLA
                     AADEFDASRMHQLTPPGAAQLAAQPGTAVLTHHGLTGEHVVVSADGRVRGVLDWTEAAF
                     GDPAEDIAGLAVAVGSPAAVRAATLAGYGPRPCLRGLWLARCDTVMRLTGHLEGRTGGD
                     GTLLRARLSRVWEPILLERVTEFKDDETEP"
     gene            complement(5871..6998)
                     /locus_tag="AMK32_RS27350"
                     /old_locus_tag="AMK32_26850"
     CDS             complement(5871..6998)
                     /EC_number="3.4.11.9"
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0070006 - metalloaminopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1172: methionine aminopeptidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996926.1"
                     /locus_tag="AMK32_RS27350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_26850"
                     /product="aminopeptidase P family protein"
                     /protein_id="WP_073897367.1"
                     /transl_table=11
                     /translation="MTGSTPAPFTAAEYGARMERAARSAADAGLAGLLVAPGPDMVWLT
                     GYTPTAVTERLTVLVLAPGREPVLVVPTLEAPDAESAVGAAALTLRDWTDGKDPYAVTA
                     ALLDDGGRFGISDNTWSLHLLGLQRTLPGTSYAALTDALPMLRAVKDAAEVDLLAAAGA
                     AADAAFEEIRKVPFAGRRESEVGHDLAGLLRRFGHSQVDFTIVGSGPNGANPHHEVGDR
                     VIREGDMVVLDFGGLKDGYGSDTTRTVHVGEPTEEERRVHDVVRAAQEAGFRAVRPGAA
                     CQDVDRAARAVITDAGYGEYFIHRTGHGIGVTTHEPPYMIEGEEQPLVPGMCFSVEPGI
                     YLPGRFGVRIEDIVTVTEDGGRRLNDTTREMVIVD"
     misc_feature    complement(7089..7103)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 25.37"
                     /tool="antismash"
     gene            complement(7262..7825)
                     /locus_tag="AMK32_RS27355"
                     /old_locus_tag="AMK32_26855"
     CDS             complement(7262..7825)
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006381304.1"
                     /locus_tag="AMK32_RS27355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_26855"
                     /product="PDZ domain-containing protein"
                     /protein_id="WP_073897369.1"
                     /transl_table=11
                     /translation="MEQTVLRPKPMPGQDRRGGDTPAPARRPHAARRRGRRLRTLLLGL
                     AAGILLLLAGAGLGTVGATVIGMSRLAELQRQAPSAAPSGRAVPTAAPAPVTAGSGATL
                     GVEAVDAEKAGALVVGVHVPGPGFTAGLVRGDVLLQFGGARVDTAADLARAVARATPGK
                     TVVLTVRHSSGGYQQLTATPGVVT"
     misc_feature    complement(7809..7829)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 22.13"
                     /tool="antismash"
     gene            complement(7945..9819)
                     /gene="phsA"
                     /locus_tag="AMK32_RS27360"
                     /old_locus_tag="AMK32_26860"
     CDS             complement(7945..9819)
                     /EC_number="1.10.3.4"
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0050149 - o-aminophenol oxidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="phsA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675701.1"
                     /locus_tag="AMK32_RS27360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_26860"
                     /product="O-aminophenol oxidase PhsA"
                     /protein_id="WP_073897371.1"
                     /transl_table=11
                     /translation="MTETIEKPAARTTEEKAPEPGELTPYAAPLSVPTVLRPAADDVLR
                     ETEIALRPTWVRLHPQLPPTLMWGYDGQVPGPTIEVRRGRRIRIAWTNRIPEGGEYPVT
                     SVEVPVRAPGTPPATTEPGRGGAEPNKDVAALPAWSVTHLHGAQTGGGNDGWADNAVGH
                     GDAQLSEYPNEHQAVQWWYHDHAMNITRWNVMTGLYGTYLVRDDEEDALGLPSGDREIP
                     LLVADRNLDTDEDGRLNGRLLHKTVVVQQSNPETGKPVSLPFTGPYTTVNGRIWPYAEV
                     DAAWYRFRLVNASNARIFEFVLIDEDGEPVPETVYQIGSDGGLLPRPVPVDFDTEMPTL
                     TAAPAERFDLLVDFRALAGRTLRLVNKGPGRPPGVPDPAGDVRYPDVLEFRVRETCEED
                     TFELPEVLSGSFRRLTHDISHGHRLVLLTPPATKGAGGHPEMWEMTEVAAPDGLKLPAD
                     GIVQVTGADGTTKTYRRTARTFNDGLGFTVAEGSHEQWSFLNLAPIVHPMHIHLADFQL
                     MGRDAYDVSGFDPAVGGTRTPLRYDTGRTIPLAPNERGHKDVFRVPGNQLLRVMGRFDG
                     AYGRFMYHCHLLEHEDMGMMRPFVVMPPEALKFDHGGAHGGHGEGHTG"
     misc_feature    complement(9730..9732)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(10001..12163)
                     /gene="cyc2"
                     /locus_tag="AMK32_RS27365"
                     /old_locus_tag="AMK32_26865"
     CDS             complement(10001..12163)
                     /EC_number="4.1.99.16"
                     /EC_number="4.2.3.22"
                     /EC_number="4.2.3.75"
                     /codon_start=1
                     /gene="cyc2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018564389.1"
                     /locus_tag="AMK32_RS27365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_26865"
                     /product="germacradienol/geosmin synthase Cyc2"
                     /protein_id="WP_073897373.1"
                     /sec_met_domain="T1TS (E-value: 1.6e-82, bitscore: 273.1,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQPFELPHFYMPYPTRLNPHLDQARAHSTAWAREMGMLEGSGIW
                     EQADLEAHDYGLLCAYTHPDCDGPALSLITDWYVWVFFFDDHFLDMFKRTQDRAAGKAH
                     LDRLPLFMPLDPATPVPEPGNPVEAGLRDLWARTVPAMSVDWRRRFSVATEHLLNESMW
                     ELSNINEGRIANPVEYIEMRRKVGGAPWSAGLVEYATAEVPARVAATRPLRVLMETFSD
                     AVHLRNDLFSYQREVEDEGENSNGVLVLEKFFGCTTQEAAETVNDILTSRLHQFEHTAL
                     TEVPAVALEQALRPDEAAAVAAYTKGLQDWQSGGHEWHLRSSRYMNEGARAGTPWRIPS
                     GPGASAADVGALLAGAARERLRAHSHVPHQKVGPSLIPEFHMPYELALSPHLDTARRRL
                     VDWSHRTGILQEGVWDEDKLAAYDLALCSAGLDPGATPEALDLSAQWLAWGTYGDDYYP
                     LVYGHRRDLATARLTTARLSDCMPVEGERTLVPGNAMERGLIDLWDRTAAGMTPDQRRG
                     LKAAVDSMTESWVWELSNQLQNRIPDPVDYLEMRRATFGSDLTLSLCRMGRGPAVPPEV
                     YRSGPVRSLENAAVDYACLLNDIFSYQKEIEYDGEIHNAVLVVQNFFGVDYPTALGVVH
                     DLTTQRMQQFEHVIAHELPVLYHDFRLSEAARAAMDGYVLDLQNWLAGILNWHRRVDRY
                     KAEWLGRRAHGFLPDRAPGTPALSPA"
     misc_feature    complement(12227..12242)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.75"
                     /tool="antismash"
     gene            12340..13167
                     /locus_tag="AMK32_RS27370"
                     /old_locus_tag="AMK32_26870"
     CDS             12340..13167
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (20-241). E-value:
                     2.8e-27. Score: 87.8. Matches aSDomain:
                     nrpspksdomains_AMK32_RS27370_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675699.1"
                     /locus_tag="AMK32_RS27370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_26870"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_073897374.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.1e-18, bitscore:
                     62.7, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 1.1e-21, bitscore: 72.5,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSFVLPHEVHGDGAHKVFAVHGWFADRTAWAAVLPDLDRTAFTY
                     ALVDLRGYGAAREAVGSYTTAEAAADLVELADRLGWERFSVVGHSMGGAVAQRLLSVAP
                     HRLRRIAGVSPVPAAGMPLPDEQGELFRDAGHKAENRRAIIDFTTGSRRPAAWLDRMVA
                     RSLERSDAKAFRAWLDSWAGDDFRADVEGSEVPALAVAGELDPALSPAVLRETWLTWYP
                     RAELVALPTAGHYAMDEAPLDLIRVVEDFLRADGADGAGGATGRDRAAAGEPA"
     aSDomain        12400..13062
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMK32_RS27370_Abhydrolase_1.1"
                     /evalue="2.80E-27"
                     /label="AMK32_RS27370_Abhydrolase_1.1"
                     /locus_tag="AMK32_RS27370"
                     /protein_end="241"
                     /protein_start="20"
                     /score="87.8"
                     /tool="antismash"
                     /translation="VHGWFADRTAWAAVLPDLDRTAFTYALVDLRGYGAAREAVGSYTT
                     AEAAADLVELADRLGWERFSVVGHSMGGAVAQRLLSVAPHRLRRIAGVSPVPAAGMPLP
                     DEQGELFRDAGHKAENRRAIIDFTTGSRRPAAWLDRMVARSLERSDAKAFRAWLDSWAG
                     DDFRADVEGSEVPALAVAGELDPALSPAVLRETWLTWYPRAELVALPTAGHYAMDEAP"
     CDS_motif       12595..12630
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMK32_RS27370_0001"
                     /evalue="3.10E-04"
                     /label="NRPS-te1"
                     /locus_tag="AMK32_RS27370"
                     /protein_end="97"
                     /protein_start="85"
                     /score="13.3"
                     /tool="antismash"
                     /translation="VVGHSMGGAVAQ"
     gene            13164..14444
                     /locus_tag="AMK32_RS27375"
                     /old_locus_tag="AMK32_26875"
     CDS             13164..14444
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015493378.1"
                     /locus_tag="AMK32_RS27375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_26875"
                     /product="cytochrome P450"
                     /protein_id="WP_073897376.1"
                     /sec_met_domain="p450 (E-value: 9.5e-18, bitscore: 59.1,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVPEAPPVPDVFDPRRYARGVPYDDYRVLRDHHPVAWQEEPEVL
                     GWPAGPGFWAVTRHADVVRVLKDAQVYSSHLGATQIRDPDPADLPYIRRMMLNQDPPHH
                     NRLRRLVSRAFTPARVERFADLARERARTLLAGALERARQGDGTADLVATVTDEYALLN
                     LADLLGVPEGDRRLLLRWTQRVIGYQDPDEAGEPVRDGAGRPVDPRSPAMLGDMFAYAR
                     DLAAHKRRHPADDVMTTLAQDGRLAPAELEMFFFLLTVAGNDTVRSAAPGGLSALAGHP
                     EAYELLRAGKAEPSAAVEELLRWHPPVLTFRRTAARDTELAGRRIRAGDKVVVFHASAN
                     RDERVFAGPDRLDLTRSPNPHVSFGDGPHVCLGAHFARLQLRLLYEETVRAVPRPRPAG
                     PPGRLVSHFINGVKSLPMHLVRPGTSG"
     gene            complement(14389..15603)
                     /locus_tag="AMK32_RS27380"
                     /old_locus_tag="AMK32_26880"
     CDS             complement(14389..15603)
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010034217.1"
                     /locus_tag="AMK32_RS27380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_26880"
                     /product="damage-control phosphatase ARMT1 family protein"
                     /protein_id="WP_073897875.1"
                     /transl_table=11
                     /translation="MADTPFAPVILGNEPGSFPHSVLAERHPAIISQVRDAFPYGPGQH
                     RALDELLKSCTEGTVEPLPADAPDRDRWQEWDLADHTGRSWYDVPWLWSESWFYRRLLQ
                     AVGYFGPGAWQGVDPFRPFKRAELDAPETGEELAALDGLRDLPEEDRARALLHGSLWGN
                     RADLGFRLSAAGAEAREPAPALVADDSETLWSLLPPGGAGTLVLVADNAGRELVPDLLL
                     IAHLLTEGRAARVVLHVKPYPYYVSDATTADVVDALRRLRTAPGAAGEYGRALWSALGD
                     GRLDVRAHPFSCAPLPYERMPGDLRADFAAATLTLLKGDLNYRRLVGDRLWPPTTPFAR
                     VTEHFPGPVGALRTLKSDVITGLSARTEDALVAAEGQRWRTDGTHALIQMSPAGRGASA
                     ATSRR"
     gene            complement(15626..16273)
                     /locus_tag="AMK32_RS27385"
                     /old_locus_tag="AMK32_26885"
     CDS             complement(15626..16273)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675696.1"
                     /locus_tag="AMK32_RS27385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_26885"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_073897378.1"
                     /transl_table=11
                     /translation="MARQLRAEQTRATIITAAADLFDQHGYESTSLSDIVAHAKVTKGA
                     LYFHFAAKEDLAHAILELQADAARQLVNEVEGRGYSSLESLMRTTFGIARLAVEDPVPR
                     AGLRLATADIAVRPPMRHPFTEWLEFATRKFTGAVRESDVHGDLDVGMVAHSLVCFFVG
                     TRVAGRSLEPVGRLPRRVAEMWHLMIRGLVPVHRRPRYVSLATQLEREIRTA"
     misc_feature    complement(16259..16261)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    16317..16334
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.23"
                     /tool="antismash"
     gene            16710..17663
                     /locus_tag="AMK32_RS27390"
                     /old_locus_tag="AMK32_26890"
     CDS             16710..17663
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010034207.1"
                     /locus_tag="AMK32_RS27390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_26890"
                     /product="lytic polysaccharide monooxygenase"
                     /protein_id="WP_073897379.1"
                     /transl_table=11
                     /translation="MTRNTARLGVTAAAAAAPLLLLPWTAGPALAHGAPTDPVSRVYAC
                     SPEGGDAARSTACAAAVAANGAPFTAWDNLRVAGVAGRDRQVIPDGRLCSGNLPAYRGL
                     DLARRDWPATRLTPGGRLTMTYASTIAHEGTFRLYLTRPGYDPAKPLKWSDLPERPFAE
                     ITDPPLRSGAYRFGVKLPADRTGRQVLYTIWQNSSTPDTYYSCSDVVFPGGGTAAGAAR
                     AAGTAPAPASQKPSARAGAPSAEGGSPAKSKPSAASATPSAKERPRKSDAAADAAPVAE
                     ATRGGSGPSAPLLAAGAAAVLVLTGGAALALRLRRR"
     gene            complement(17679..18332)
                     /locus_tag="AMK32_RS27395"
                     /old_locus_tag="AMK32_26895"
     CDS             complement(17679..18332)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675693.1"
                     /locus_tag="AMK32_RS27395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_26895"
                     /product="Tat pathway signal sequence domain protein"
                     /protein_id="WP_073897381.1"
                     /transl_table=11
                     /translation="MRTRSLLALAGTATALALTVAAPASADGAAVLTTGGAGGTAVAAG
                     DVLTAPLASGTSANFYSSATGTSGVKCASSQFTATVTDNPSAPGTATESVTAHTFDSGS
                     CTSNVIGVLGVNGITIDNLPYTATVASDGTLSVLPPSGSVVQATVKLRTLLGSVSCVYR
                     AAGLTGRADNTDSSITFTSQQFTKSSGSSLCFANGYFTAKYAPVTDGGAPVYVN"
     misc_feature    18694..18712
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 19.46"
                     /tool="antismash"
     misc_feature    complement(18730..18744)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.32"
                     /tool="antismash"
     gene            18970..19671
                     /locus_tag="AMK32_RS27400"
                     /old_locus_tag="AMK32_26900"
     CDS             18970..19671
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996942.1"
                     /locus_tag="AMK32_RS27400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_26900"
                     /product="DUF6230 family protein"
                     /protein_id="WP_073897383.1"
                     /transl_table=11
                     /translation="MASSPDVPSADSTPENPDPGASSEVPGAAATGGEGGERRGRVRAR
                     RAAVMAVPATLVLAGLAVLTAQGALGVQFAISGMPFTVTATELDGTGFEQFGGLDTMAD
                     GSPNAGDTGGQVLVVTSAIKNATLTKLCQSVDLGGTNLLITAGSGAEKVSAADLTTDST
                     ELTGDAAFGNIEIGNDASTLTKAGVKGPIGVFSQQADTVRIAHLRQTNYATTAGVFKLP
                     GLKLRFSESGC"
     gene            19677..20135
                     /locus_tag="AMK32_RS27405"
                     /old_locus_tag="AMK32_26905"
     CDS             19677..20135
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675691.1"
                     /locus_tag="AMK32_RS27405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_26905"
                     /product="DUF6114 domain-containing protein"
                     /protein_id="WP_241841184.1"
                     /transl_table=11
                     /translation="MPDRPRREPRLAFRGWRARRPFWGGLLLALGGGEILLTEKASLKV
                     VMHIGMQGLAGYLLPTLMVLLGLLVLVNPTQRLFYSVTGVLVSLGTWLTSNLGGFLLGL
                     LLGVAGSCLTFGWLPDQEPRAGRRRRRERARAERRAARRPRVSPGIRS"
     misc_feature    complement(20157..20175)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 18.41"
                     /tool="antismash"
     gene            20232..20687
                     /locus_tag="AMK32_RS27410"
                     /old_locus_tag="AMK32_26910"
     CDS             20232..20687
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675687.1"
                     /locus_tag="AMK32_RS27410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_26910"
                     /product="TerB family tellurite resistance protein"
                     /protein_id="WP_073897387.1"
                     /transl_table=11
                     /translation="MALWDRFKESASQMQTQLVAKKNDLKSGAFRDASMAMCALVAAAD
                     GTVDPSERQRVAQLISTNEVLQNFPADDLRRRFEENLAKLTTDFAFGKVSVLQEVAKAK
                     KKPAEARAVVQIGIVIGGADGDFDKTEQAVVREACYTLDLPPHEFDL"
     gene            complement(20787..21743)
                     /locus_tag="AMK32_RS27415"
                     /old_locus_tag="AMK32_26915"
     CDS             complement(20787..21743)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675685.1"
                     /locus_tag="AMK32_RS27415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_26915"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_073897389.1"
                     /transl_table=11
                     /translation="MTYTTLISRSIRRNRGAAVVALAAATALLAGCSSNDKADDPLSEG
                     KASGDGVVVGSNNFPESTLLADIYGEALKAKGIKVTYKPNIGSRETTYGLIKNGSLSVL
                     PEYNGALLAYLDPKATPKTADATTTAIEAKLDSKLTLLKPSAAQNKDSVTVNAATAKKY
                     HLTEKSSIADLKDVAKDLVIGGSPEFQTRQQGLVGLKSVYGLQFKSFKALDAGGPLTQA
                     ALKKDAVQAADLFTTDPTIAKEKFVVLQDPKNLFGFENVQPLVYKGALNQKGADALDAV
                     SAKLDTATLLDLDTQVQTENKDPLDVAKAWLKSAGLD"
     misc_feature    21836..21846
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     misc_feature    21842..21857
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.87"
                     /tool="antismash"
ORIGIN
        1 ccgtgccgtt cccgcccgag gtgcccggtg agaaggacgc gctgaccgcg gccgcgctgc
       61 ggctgcgggc gcggcggccg gacgtcttcg gcacggcggc ggcgtacgcg ccgctggccg
      121 ccgaggggcc cgcggcggag cactgtgtgg cgttcgcgcg ctcgggcgag gcggtcacgg
      181 cggtgacccg gctctcgctg cggctcgcgg aggcgggggg ctggcgggag acccggctgc
      241 cgctgccgcc cggacggtgg gccgacgtcc tctccccgga ccgggagttc accggcgacg
      301 cgcgggtggc ggacctgttc gagcaccggc ccgcggtgct gctggagcgg gtccccggca
      361 gctgagacgt acgtcggccg gccgcggccc gcaccagcgc cgttcgggcg gagtgcgggc
      421 ccggacggcc gccgggtgac tgcgtccggg cgcccccggc tcccgccccg tcgcgtgctt
      481 gacagttcac tcatcccgtg ggggacttgg agtgcgaagc cgggcggaaa caagtcgggg
      541 gtgagtctcc tgccggagct gcgctacccc agcgttcccg aactggtggc ccatgcacgc
      601 gtgttggccg ctcaggagcc agggctgtgc acgctgcggc aggtgggcag ctcgcgggcg
      661 ggcagacccc tgcacctgct gtcggtgggg cacgccgagc gagcggtgct ggtcgtcgcc
      721 ggtgcgcacg ccaacgagcc ggcgggcggc tccaccctgc aggcggtggc ggaacgggtc
      781 ctggcggagc gcgagttgcg gtcgggcacg tcctggcact tcctgctgtg cgcggacccg
      841 gacggggcga gcctgcacgt gaccccggcg ccgcgcagcc tcttcgacta ccacctcggc
      901 ttctaccggc ccacgggcgc ggagcagccg gagtggtcgc cgtcggtgct gccgccggac
      961 cggctgccgc ccgagacggt ggccctgacc ggggtgatcg acgagctgcg cccgtacctc
     1021 caggtgacgc tgcacggcac cgatctgggc ggcagctggg tgcagttgac gcgggacgtg
     1081 ccgggcctcg ccgaaccgtt cgcgaagtcc gcggcggagc tgcacatccc ggtggagacc
     1141 ggcgcctcgg acgcggcggg ctggccggcc tccgggcccg gggtgcatgt gatgccaggc
     1201 ccggagtcgg gcgtcgccta ccccagcatg cccgacgacg cgcggcacag cacctggtac
     1261 cacgcgcacc gccacggcgg tctgacggcc gtggtggagg tgccgatgtg ggcgagcgac
     1321 ctggtggacg acccggcgcc gcacccggcg cccgcggccg ccatgcgccg gctggcccgg
     1381 cggctgctgc gggactcgct ggaggtggag ggggtgctcg ccgaggcact gccccggctg
     1441 gacggcgcgg acgggccgct gctgcgggcc gcgcgctggg cgctggagct gatcccgggt
     1501 ctcgccgagg actgggtgca cacgcccccg gccgccacga cgatggcgta cgtgggcagc
     1561 gtggacgcct tcggacggcg gctgccgctg cgggcggcgg cgatgctgct ccgggtgctg
     1621 cgggaggcgg acgacagcgc ggccccgcgg cttgaacagc tcgtggcgct gtggtgcgac
     1681 gccttcgcga cgcgtttccg ggcccgctgg gtgccgctgg agaaccaggt cgagcatcag
     1741 tcgcggacgg tgctggtggc cgcgcagcag gcccgggagc aggtggggtg aggcggtgcg
     1801 gcgccccgca ccgcccggcc cgaaagcccg cggggctcag tcgtcgaagg cgaggaccgc
     1861 tccggtccgc gcttccatga cgcaccggct cgtgtacgtc tggcggaagt cgacggaccg
     1921 tccgtcccac agtccgcgcg cgtggagggt caccggcgcg aagatcatgg ggcagaacac
     1981 gttcctggcc gggatgcggt cgatgtcgcc gccggaggcg ccgagttcgg cgcacgcctc
     2041 ggcggcgcgc gcgtgcccga ggggcgggtc gcacagcagc agaccgccgc gcggaccgcc
     2101 cggccggccg tcacccttgg tgaccgaaag gtagagccag ttgccggtag gggtgtcgcc
     2161 ggccgccgcc cgggccgggc ccgcggcgag gagcccggcg gccgccagca gggcgccggc
     2221 cgccgctgtc gctctggtga tgtaggtcat gcagggtcca tcggcacgga gggccgggtt
     2281 ccgcagtgcg gctcacccga tcgggacggt acgcgcgcgc gacggagcgc cagttcgaag
     2341 gcggccgggt tccgttcggc ccggtgcggg cgtcaggcgg tggcgagccg gaacgccatc
     2401 ctgccgaagg agacctggtc gccctcgcgg acgacgacgg agccggtcac ccggcggccg
     2461 ttgacggtgg tgccgttggt ggagccgagg tcccgcagga tccacatccc gccgcggcgg
     2521 ctgagttcgg cgtggacgcg ggagacggtc tcgtggttca ggcgcagccc gctggcgggg
     2581 tcgcggccta tgcgcagcgg gtgggtgtgc tcggggtgcg gcagcagcag cttgggcagc
     2641 cgctcggcct gccaggcccg gcgcagccgt acggtgaagc cggagacggc ctcgacactg
     2701 ccgaggacca tgcgggagaa gcggttgtca cggggcaggt cggctacgag gacggcgagt
     2761 tcgtcggagc ggcgcgcggc cagggccagt tccatgcggc gcacgaacgt gtcgtgggac
     2821 agccgtccca cggcgacgcc gtcacgcagt gcctgcagcg ccttgtcgcg ctccgcgtcg
     2881 gacaatcgcg cggggtacgt ggagaactcg aaggacgacg tcacgctcgt gattgtcggg
     2941 cagtgaaccc cgagtgtcca gaaaacgcgg aaccggtgcc gaaacgcggg tacttccgcg
     3001 acaccggccg ggaaaggacc gattgcgaag cggatcgatc gcccgggcgg cacgatggag
     3061 tcgcgggaca tcacggtgag cagacgaagg ggaaccgtcc gtgcagttcg aggtgtgggc
     3121 accgcaggca gaccgagtga cgctccagtg cgagggcggc acgcgcgcgt tggcgcgcga
     3181 tcccgagcgc gcgggctggt ggacgggtga ggcggaggcg gcggacggcg cccggtacgg
     3241 gttcgcgctg gacgacgggc cggtgctgcc cgatccgcgc tcgcgccgtc agccggacgg
     3301 cccggacggc ctgagcgcgg tggtggacca cggcgggtac acctggcggt cgcggtgggc
     3361 cgggcgcggg ctgccgggcg cggtgctgta cgagctgcac gtgggcacgt acacgcgcga
     3421 gggcaccctg gacgcggccg cggcccggct ggagcatctg gtggaactgg gtgtcacgca
     3481 tgtggagttg atgccgctgt gcccgttccc cggccggcac ggctgggggt acgagggggt
     3541 gtcgttgtgg gcggtgcacg agccgtacgg cggcccggag gcactgaagc ggttcgtcga
     3601 ccgggcgcac gaactcggcc tgggcgtcgt cctggacgtc gtgcacaacc atctgggccc
     3661 ctccggcaac cacctgccgt cgttcggccc gtacttcacg gacacccacc acacgccgtg
     3721 gggctcggcc gtgaacctgg acgcccccgg ctcggacgag gtccgggcgt tcctgctgga
     3781 gagcgcgctg gcgtggctgc gggactaccg cgtcgacggt ctgcgcctgg acgcggtgca
     3841 cgcgctgtac gacacgcgcg cgtgccactt cctggaggag ctgtcggccg ccgtggacgg
     3901 actcgccgag gaggtgggac gcccgctgtt cctgatcgcc gagtcggatc tgaacgaccc
     3961 gcggctcatc accccgcgcg cggagaacgg cctcggcctg cacgcgcagt ggaacgacga
     4021 cttccaccac gcgctgcgca ccacgctgac cggtgagtcg cagggctact acgccgactt
     4081 cgcccgcgct ccgttcgccg cgctggcgaa gacgctcacc ggcggttact tccacgacgg
     4141 cacgtactcc agcttccggg gccggcggca cggccgtcca ctggaccgcg cgcgcgtggc
     4201 cgggcaccgg ctgctcggct acagccagac gcacgaccag gtcggcaacc gcgcccaggg
     4261 cgaccggctc gccgccgtcc tctcccccgg tctgctggcc tgcgcggcgg ccctcacgct
     4321 gacggcgccg ttcaccccga tgctgttcat gggtgaggag tgggccgcgg gcacgccgtg
     4381 gcagttcttc accgaccaca ccgaccccga gctggccgag gcggtacggc ggggcaggcg
     4441 acgggagttc gcggagcacg ggtgggccga ggaggacgta ccggacccgc aggacccggc
     4501 gacccgggag cggtcctgcc tggactggtc ggagccggag cgcgagcccc acgcgcgcgt
     4561 gctggcctgg taccggcggc tgatcgcgct gcgccacgag cagcccgacc tcaccgaccc
     4621 cgatctcgcc gacaccaagg tggcgtacga cgacgaggcc cgctggctgg ccttccggcg
     4681 cggggacgta cgggtggcgg tgaacctggg caaggaggcg gcggccatcc cgctcggcac
     4741 cggccggacg gaggtgctgg ccgcgtggga gccggtcgag gcgcccggcc cggacgggct
     4801 gctccaggtg cccggggagt cctgcgtggt gctgacccag ccctgagccg cccccgggcc
     4861 gctcagggcc ctggaggacg tccctagggc tcggtctcgt cgtccttgaa ctccgtcacc
     4921 cgctccagca ggatcggctc ccagacccgg ctcagacggg cgcgcagcag tgttccgtcg
     4981 ccgcccgtgc ggccttcgag gtggccggtg aggcgcatga cggtgtcgca gcgggccagc
     5041 cagaggccgc gcaggcatgg gcgggggccg tagccggcca gggtggcggc gcggacggcc
     5101 gccggggagc cgacggcgac ggcgagcccg gcgatgtcct cggcggggtc gccgaacgcc
     5161 gcctcggtcc agtccaggac gccgcgcacg cgtccgtcgg cgctgaccac cacgtgttcg
     5221 ccggtcagtc cgtggtgggt gaggacggcg gtgccgggct gcgcggcgag ctgggccgcc
     5281 cccggcgggg tgagctggtg catccgggag gcgtcgaact cgtcggcggc ggcgagccgt
     5341 tcggccgcgt ggacggccat gcggcgcagc gcctccagcg accgcggggc ggtacggggg
     5401 acgccggcgg tctcggcctg gcgctggggc accgcgcgca gcccggtgag cagcccggcg
     5461 aggtcggcct cgccgacggc ggagacgtcg tgctcgtcgg ccgtgccgcc gggcaccagg
     5521 gtgtcgaggg tgtaggcgag gccgggcgcc cagtcgccgt gcgcgacgct ggtgggcacg
     5581 gcgacgggca cgtgcgggcg caccaggtcg cgcagccgca gttcgcgacg gcggcgggcg
     5641 gaggcctcgc ggtcgggggc gaggcgcagc acgtggcggg tgccgaccca ccaggtgtgc
     5701 gcgtggcctt cccggacggg ccgcacgtcg ggtccgccgg tgccgccggt gccctcgtcg
     5761 agcagcgagc ggaccagtct gcggacggtg tccgcggtgg gtgtcggtgc ctgggtcatg
     5821 ggtcgcgcgt gtgccgttcc ggtgtcgact ggggatgtcc tcggggccgc tcagtccact
     5881 atgaccatct cacgagtggt gtcgttgagg cggcggccgc cgtcctcggt gaccgtgacg
     5941 atgtcctcga tgcgcacgcc gaacctgccc ggcaggtaga tgccgggctc cacggagaag
     6001 cacatgccgg gcacgagcgg ctgctcctcg ccctcgatca tgtacggcgg ctcgtgcgtg
     6061 gtgacgccga tgccgtgccc ggtgcggtgg atgaagtact cgccgtagcc ggcgtcggtg
     6121 atcaccgcgc gggcggcgcg gtcgacgtcc tggcaggccg cgcccggccg tacggcgcgg
     6181 aagccggcct cctgggcggc gcgcacgacg tcgtggaccc ggcgctcctc ctcggtgggc
     6241 tcgccgacgt ggaccgtgcg ggtggtgtcg gagccgtagc cgtccttcag cccgccgaag
     6301 tcgaggacga ccatgtcgcc ctcgcggatg acgcggtcgc cgacctcgtg gtgcgggttg
     6361 gcgccgttgg ggccggagcc gacgatggtg aagtcgacct gggagtggcc gaagcggcgc
     6421 agcaggccgg cgaggtcgtg gccgacctcg gactcgcggc gcccggcgaa ggggaccttc
     6481 cggatctcct cgaaggcggc gtcggcggcc gcgcccgcgg ccgcgaggag gtccacctcg
     6541 gcggcatctt tcaccgcgcg gagcatgggc agggcgtcgg tgagggcggc gtaggaggtg
     6601 ccgggcaggg tccgttggag gcccagcagg tgcagggacc aggtgttgtc gctgatgccg
     6661 aaccggccgc cgtcgtcgag gagggccgcg gtgaccgcgt aggggtcctt gccgtcggtc
     6721 cagtcgcgca gggtcagcgc cgcggctccg accgcgctct cggcgtccgg ggcctccagg
     6781 gtgggcacga cgaggacggg ctcgcggccg ggggcgagga ccaggacggt gagccgttcg
     6841 gtgacggcgg tgggtgtgta gccggtcagc cacaccatgt ccggccccgg cgccacgagg
     6901 agcccggcga ggccggcgtc ggccgccgag cgtgcggcac gctccatgcg ggcgccgtac
     6961 tcggcggcgg tgaagggcgc gggcgtacta ccggtcatcc gggcctccgg gcgcgggtgg
     7021 ggaaacgggc gacggcgtct cgggcagcat cctgcccggc cgggcggggc ggcgcgagcc
     7081 ggtcgccggg ggccggccgg cccggtgacc gcgcgggcgc cggggcggcg ggtcgcccgg
     7141 ggcgcgcgga gaggaggctc ggcatggggc catcatggcg cgcggggcgg gaggccacca
     7201 gcgggtttcg cgggggcgtg ggtggcgcgc cccggccggc ccgggtggtc cgcgtgtccc
     7261 ctcaggtcac cactcccggc gtcgccgtca actgctggta gccgccgctg ctgtgacgca
     7321 cggtgaggac gacggtcttc ccgggcgtgg cgcgggcgac ggcccgggcg aggtcggcgg
     7381 cggtgtcgac gcgggcaccg ccgaactgga gcaggacgtc cccgcggacc aggccggcgg
     7441 tgaaaccggg gccgggcacg tggacgccca ccaccagcgc gcccgccttc tccgcgtcga
     7501 cggcctccac cccgagggtc gccccggagc cggccgtgac gggggccggg gcggccgtgg
     7561 ggacggcccg gcccgagggg gccgccgacg gggcctggcg ctgcagctcg gccagtctgc
     7621 tcatgccgat gaccgtggcg ccgacggtgc cgagtccggc accggcgagc agcagcagga
     7681 tccccgcggc caggccgagc agcagggtcc gcagccgccg cccgcgccgc cgggcggcgt
     7741 gcgggcgacg ggccggggcg ggggtgtccc cgccccggcg gtcctggccg ggcatcggct
     7801 tgggccgcaa cacagtctgt tccatggttc gctcgcctcc ggctggtgct ctacccgggg
     7861 caccgggccg cgacgagaca cgaacgagtg agactggccg gagggtcgcg cagggtagtc
     7921 atggccgacg aggcaccggc ccgctcagcc ggtgtggccc tcgccgtggc cgccgtgcgc
     7981 ccctccgtgg tcgaacttca gggcctccgg cggcatcacg acgaacggcc tcatcatgcc
     8041 catgtcctcg tgctccagca ggtggcagtg gtacatgaac cggccgtacg ccccgtcgaa
     8101 gcggcccatg acccgcagca gctggttgcc cggcacccgg aacacgtcct tgtgaccgcg
     8161 ctcgttgggc gcgagcggga tcgtccggcc ggtgtcgtac cgcaggggcg tccgggtgcc
     8221 gccgaccgcg gggtcgaagc cggagacgtc gtaggcgtcc cgtcccatca gctggaagtc
     8281 ggccaggtgg atgtgcatgg ggtgcacgat gggcgcgagg ttgaggaagc tccactgctc
     8341 gtggctgccc tcggcgacgg tgaaccccag accgtcgttg aacgtccgcg cggtgcgccg
     8401 gtaggtcttc gtggtcccgt cggctccggt gacctgcacg atgccgtcgg ccggcagctt
     8461 caggccgtcc ggggccgcga cctcggtcat ctcccacatc tccggatggc cgccggcgcc
     8521 cttggtggcg ggcggggtga gcaggaccag gcggtggccg tgcgagatgt cgtgggtcag
     8581 ccggcggaag gagccggaga ggacctcggg cagttcgaag gtgtcctcct cgcacgtctc
     8641 gcggacccgg aactccagca cgtccgggta gcgcacgtca ccggccgggt ccggcacgcc
     8701 cggcggccgg ccgggaccct tgttgacgag ccggagggtg cggcccgcca gggcgcggaa
     8761 gtcgacgagc aggtcgaaac gctcggccgg ggccgcggtc agcgtgggca tctccgtgtc
     8821 gaagtcgacc ggcaccgggc gcggcagcag tccgccgtcg ctgccgatct ggtacacggt
     8881 ctccggcacc ggctcgccgt cctcgtcgat caggacgaac tcgaagatgc gcgcgttgga
     8941 ggcgttgacc agccggaagc ggtaccaggc cgcgtcgacc tcggcgtacg gccagatacg
     9001 gccgttgacc gtggtgtagg gaccggtgaa gggcagcgag accggcttgc cggtctccgg
     9061 gttgctctgc tggacgacca ccgtcttgtg cagcagccgg ccgttgaggc ggccgtcctc
     9121 gtcggtgtcg aggttgcggt cggcgacgag caacgggatc tcccggtcgc cggagggcag
     9181 ccccagggcg tcctcctcgt cgtcacggac gaggtaggtg ccgtacaggc cggtcatcac
     9241 gttccaccgg gtgatgttca tggcgtggtc gtggtaccac cactgcaccg cctggtgttc
     9301 gttggggtac tccgacagct gggcgtcgcc gtggccgacg gcgttgtccg cccagccgtc
     9361 gttgccgccg cccgtctggg cgccgtgcag atgggtcacc gaccaggcgg gcagcgcggc
     9421 cacgtccttg ttcggctcgg cgcccccgcg gccgggctcg gtggtggccg gcggggtgcc
     9481 gggcgcgcgg acgggcacct cgacggaggt gaccgggtac tcgccgccct cggggatgcg
     9541 gttggtccag gcgatgcgga tccgccggcc gcgccgcacc tcgatggtcg ggccgggcac
     9601 ctggccgtcg tagccccaca tcagggtcgg cgggagctgc gggtgcaggc gcacccaggt
     9661 ggggcgcagg gcgatctcgg tctcgcgcag gacgtcgtcc gcggcgggac gcaggacggt
     9721 gggcacggat aacggcgccg cgtacggcgt gagttcaccg ggttcgggtg ccttctcctc
     9781 cgtggtccgc gcggccggct tctcgatggt ctcggtcatg gtcgaacacc cccgtgtgtc
     9841 gcgaagcttg gtggtccgtc gttcctctcg ttgcgcaaga ccccgtgggc gtcacggaag
     9901 ttccctgaat gcccggttcc gtacgcggag attcggcgac cggcgccgga cgtgccacga
     9961 gccgtggacc ggtcccggtc cacggctcgt acggaggcgg tcaggcgggt gacagcgccg
    10021 gggtgccggg ggcgcggtcc ggcaggaagc cgtgggcccg gcggccgagc cactcggcct
    10081 tgtagcggtc gacgcggcgg tgccagttca ggatgccggc gagccagttc tgcaggtcga
    10141 ggacatagcc gtccatggcg gccctggccg cctcggacag ccggaagtcg tggtacagca
    10201 cgggcagttc atgggcgatc acgtgctcga actgctgcat gcgctgggtc gtcaggtcgt
    10261 ggacgacgcc gagcgcggtc gggtagtcca cgccgaagaa gttctgcacg accaggacgg
    10321 cgttgtggat ctcgccgtcg tactcgatct ccttctggta cgagaagatg tcgttcagca
    10381 ggcaggcgta gtcgacggcg gcgttctcca gggagcgcac cgggccgctg cggtacacct
    10441 ccgggggtac ggcggggccc cggcccatgc ggcacaggct cagggtgagg tccgagccga
    10501 acgtggcgcg ccgcatctcc aggtagtcga ccgggtcggg gatgcggttc tgcaactggt
    10561 tggagagctc ccacacccag ctctcggtca tggagtcgac ggccgccttg aggccgcgcc
    10621 gctggtcggg cgtcatgccg gcggcggtgc ggtcccagag gtcgatcagc ccgcgctcca
    10681 tggcgttgcc cgggacgagg gtccgctccc cctcgaccgg catgcagtcc gacagccggg
    10741 ccgtggtcag ccgggcggtg gcgaggtcac ggcggtggcc gtacacgagg gggtagtagt
    10801 cgtcgccgta cgtcccccag gcgagccact gggcgctgag gtcgagggcc tcgggagtgg
    10861 cgcccgggtc cagtccggcg gagcacagcg cgaggtcgta cgcggcgagc ttgtcctcgt
    10921 cccagacgcc ctcctggagg atgcccgtgc ggtgcgacca gtcgacgaga cgccgccggg
    10981 cggtgtccag gtgcgggctc agcgcgagct cgtagggcat gtggaactcg gggatcaggg
    11041 aggggccgac cttctggtgg ggcacgtggg agtgggcgcg cagccgctcc cgggcggcgc
    11101 cggcgaggag cgcgccgaca tcggcggcgg aggcccccgg accgctcggg atccgccacg
    11161 gcgtgccggc gcgggcgccc tcgttcatgt agcggctgga gcgcaggtgc cattcgtggc
    11221 cgccggactg ccagtcctgg agtcccttgg tgtaggcggc gaccgcggcg gcctcgtccg
    11281 gcctcagggc ctgctccagg gcgacggccg ggacctcggt cagcgcggtg tgctcgaact
    11341 ggtgcagccg tgaggtgagg atgtcgttga cggtctcggc ggcctcctgg gtggtgcagc
    11401 cgaagaactt ctccaggacg agcacaccgt tgctgttctc cccctcgtcc tccacctcgc
    11461 gctggtagga gaacaggtcg ttgcgcaggt ggacggcgtc ggagaaggtc tccatcagca
    11521 cccgcagcgg ccgggtggcg gcgacccgcg ccggcacctc ggcggtcgcg tactccacca
    11581 gccccgccga ccagggggcg ccacccacct tgcggcgcat ctcgatgtac tcgacggggt
    11641 tggcgatccg cccctcgttg atgttggaca gctcccacat cgactcgttg agcaggtgct
    11701 cggtggccac ggagaaccgg cggcgccagt ccaccgacat cgccggcacc gtccgcgccc
    11761 acaggtcccg cagcccggcc tcgacgggat tccccggttc ggggacgggc gtcgcggggt
    11821 cgagcggcat gaacaggggc aggcggtcca ggtgggcctt cccggcggcg cggtcctggg
    11881 tgcgcttgaa catgtccagg aagtggtcgt cgaagaagaa cacccacacg taccagtcgg
    11941 tgatgagcga gagggcggga ccgtcgcagt cggggtgggt gtaggcgcac agcagtccgt
    12001 agtcgtgcgc ctccaggtcg gcctgctccc agatcccgga gccctccagc atgcccatct
    12061 cccgcgccca cgccgtcgag tgggcgcggg cctggtcgag gtgcggattg agccgggtgg
    12121 gatacggcat gtagaagtgc gggagttcga acggctgcgt catggccggg ccctacccgc
    12181 ggccaccggg gcccatccgc cacgccggac atgatcacac catcgcgtga aaggaccgcg
    12241 aaaccctgaa cttccggggc ggacatgggc gttcgccgcg cgggccgacc gtcgtacgcc
    12301 cccttgcccg gccggccgcg cgggcgccac ggtagcccca tgacctcctt cgtactgccc
    12361 catgaggtgc acggcgacgg cgcccacaag gtgttcgccg tgcacggctg gttcgccgac
    12421 cggaccgcct gggccgccgt cctgccggac ctcgaccgca ccgcgttcac ctacgcgctg
    12481 gtcgacctgc gcggctacgg cgcggcccgg gaagccgtcg gctcgtacac gaccgccgag
    12541 gcggccgcgg acctggtgga gctggccgac cggctcggct gggagcggtt ctcggtggtc
    12601 gggcactcca tgggcggcgc ggtggcgcag cggctgctgt ccgtcgcccc gcaccggctg
    12661 cggcggatcg ccggtgtgtc gcccgtgccg gccgcgggca tgcccctgcc cgacgagcag
    12721 ggcgagctgt tccgggacgc aggccacaag gcggagaacc ggcgcgcgat catcgacttc
    12781 accaccggga gccgccgtcc cgcggcgtgg ctggaccgga tggtcgcccg ctcgctggag
    12841 cgcagcgacg ccaaggcgtt ccgggcctgg ctggactcgt gggccgggga cgacttccgt
    12901 gccgacgtcg agggcagcga ggtgcccgcg ctcgccgtgg ccggtgagct cgatccggcg
    12961 ctgtcaccgg cggtgctgcg ggagacctgg ctgacctggt atccgcgcgc cgagctggtc
    13021 gcgctgccga ccgccggcca ctacgcgatg gacgaggcgc cgctggacct gatccgggtg
    13081 gtggaggact tcctgcgcgc ggacggcgcc gacggcgcgg gcggggccac cggccgggac
    13141 cgggccgccg cgggcgagcc ggcgtgagcg tgcccgaggc cccgccggtg ccggacgtct
    13201 tcgacccgcg ccggtacgcg cgcggggtgc cgtacgacga ctaccgggtg ctgcgcgacc
    13261 accatccggt ggcctggcag gaggagccgg aggtgctggg ctggccggcg ggacccggct
    13321 tctgggcggt gacccggcac gcggacgtcg tccgggtact gaaggacgcc caggtgtact
    13381 cgtcgcacct gggcgcgacc cagatccgcg accccgatcc ggcggacctg ccgtacatcc
    13441 gccggatgat gctcaaccag gacccgccgc accacaaccg gctgcggcgg ctggtgagcc
    13501 gggcgttcac gccggcacgc gtcgagcggt tcgcggacct ggcccgggag cgggcgcgca
    13561 ccctgctggc gggggcgctg gagcgggccc ggcaggggga cggcacggcc gatctcgtgg
    13621 ccacggtcac cgacgagtac gcgctgctga acctggcgga tctgctgggc gtcccggagg
    13681 gcgaccggcg gctgctgctg cgctggaccc agcgggtcat cggctaccag gacccggacg
    13741 aggcggggga accggtgcgg gacggggcgg gccggcccgt cgacccgcgc tcaccggcga
    13801 tgctcgggga catgttcgcg tacgcgcggg acctggccgc gcacaagcgg cggcatcccg
    13861 ccgacgacgt catgacgacc ctcgcccagg acggccggct cgccccggcc gagctggaga
    13921 tgttcttctt cctgctcacc gtcgcgggca acgacacggt gcgcagcgcc gcacccggcg
    13981 ggctgtcggc cctcgccggg cacccggagg cgtacgagct gctgcgcgcc gggaaggcgg
    14041 aaccgtccgc ggccgtggag gagttgctgc gctggcatcc gccggtgctg acgttccgcc
    14101 ggacggccgc gcgggacacc gagctggcgg ggcggcggat ccgggccggg gacaaggtcg
    14161 tggtgttcca cgcctcggcc aaccgggacg agcgggtctt cgccggaccg gaccggctcg
    14221 acctcacccg ctccccgaat ccgcatgtct ccttcggtga cggcccgcac gtctgtctcg
    14281 gcgcgcactt cgcccggctg caactgcggt tgctctacga ggagacggtg cgtgccgtgc
    14341 cacggccacg tccggccggc cctccggggc ggctggtctc gcacttcatc aacggcgtga
    14401 agtcgctgcc gatgcacctc gtccggccgg ggacatctgg atgagggcgt gcgtgccgtc
    14461 ggtacgccac cgttggccct ccgccgccac cagcgcgtcc tcggtccgcg ccgaaagacc
    14521 ggtgatcacg tcggacttga gggtgcgcag cgcgccgacc ggtccgggga agtgttcggt
    14581 cacccgcgcg aacggcgtgg tcggcggcca cagccggtcg cccaccaggc gccggtagtt
    14641 gaggtcgccc ttgagcaggg tcagcgtggc cgccgcgaag tcggcccgca ggtcgccggg
    14701 catccgctcg tagggcagcg gcgcgcagga gaacgggtgg gcgcggacgt cgagccggcc
    14761 gtcgccgagg gccgaccaga gggcgcggcc gtactcgccg gccgcgcccg gggcggtgcg
    14821 cagccggcgc agggcgtcga ccacgtcggc ggtggtggcg tcggagacgt agtacgggta
    14881 cggcttgacg tgcagcacca cccgggccgc gcgcccctcg gtgaggagat gggcgatcag
    14941 cagcaggtcg gggacgagtt cgcggcccgc gttgtccgcg accaggacga gggtgcccgc
    15001 cccgccgggc ggcagcagcg accacagcgt ctcgctgtcg tcggcgacga gcgcgggggc
    15061 cggttcgcgg gcctcggcgc ccgcggcgga gagccggaag cccaggtcgg cgcggttgcc
    15121 ccacagcgag ccgtgcagca gcgcccgggc ccggtcctcc tccggcaggt cccgcaggcc
    15181 gtccagggcc gccagttcct caccggtctc cggcgcgtcg agctcggcgc gcttgaacgg
    15241 ccggaagggg tcgacgccct gccaggcgcc cgggccgaag tatccgacgg cctggagcag
    15301 ccggcggtag aaccagctct cggaccacag ccacggcacg tcgtaccagg accgcccggt
    15361 gtggtcggcc aggtcccact cctgccagcg gtcccggtcc ggggcgtcgg cgggcagcgg
    15421 ttcgacggtc ccctcggtgc agctcttcag cagctcgtcc agtgcccggt gctgtccggg
    15481 gccgtagggg aaggcgtccc gcacctggct gatgatcgcg gggtgccgct cggccagcac
    15541 gctgtgcggg aacgagccgg gttcgttgcc gaggatcacg ggtgcgaacg gggtgtcggc
    15601 catgtccgtc accgtacccc gcacgtcagg cggttctgat ctcccgctcc agctgggtgg
    15661 cgaggctgac gtagcggggg cggcggtgca ccgggaccag gccccggatc atcaggtgcc
    15721 acatctcggc gacccggcgc ggaagccgtc cgaccggttc gagcgagcgg ccggcgaccc
    15781 gggtgccgac gaagaagcag acgagggagt gggcgaccat gccgacgtcc aggtcgccgt
    15841 gcacgtcgga ctcccggacg gctccggtga acttccgggt ggcgaactcc agccactcgg
    15901 tgaaggggtg gcgcatgggg ggccgtaccg ctatgtccgc ggtggccagg cggagtccgg
    15961 cgcggggcac ggggtcctcc acggcgagcc gggcgatgcc gaaggtggtc cgcatcaagg
    16021 actccagcga ggagtagccg cgtccctcga cctcgttcac gagttgcctg gcggcgtcgg
    16081 cctggagttc caggatggcg tgggccaggt cctccttggc ggcgaagtgg aagtacagcg
    16141 cgcccttggt gaccttcgcg tgcgcgacga tgtcactcag actggtggac tcgtagccgt
    16201 gctggtcgaa cagatcggcg gcagccgtga tgatcgttgc ccgggtctgc tcagcacgta
    16261 actgcctcgc catcgtgtga cccttcctcg cgactccaac gaacgggaca tgcggtttgt
    16321 ttttcacccg ttgcatacga taactcacgg gagggcagcg ggagtccggg cggaggcctc
    16381 acggcaggac acgtgtcggc cgtacgtccg gccgtcgtcg ggacgctcgg cggcccgtgc
    16441 gcggacgaga ccagaacggc tccccccttc gtggcgcggc tgttcccggc agccgcgggg
    16501 cgacgggtgc cgcacccatg atcgccacga tacgaggcgg acggccggca cctcaacggg
    16561 gtcgcacggg gggcgcgaag cagtggaacc ggccggttcc acgcgccccc tgggcggcgg
    16621 acgggccgtt gcgctgaaca cggggggcgc acgcgccgta caggacaccg gaagaacccg
    16681 ttgccgcccc tgcccaggag acgtccccga tgactcggaa caccgcccga ctgggcgtca
    16741 cggcggccgc cgccgcggca ccgctcctgc tgctgccgtg gacggccgga cccgccctgg
    16801 cgcacggcgc ccccaccgac ccggtcagcc gggtctacgc ctgctccccc gagggcggcg
    16861 acgccgcccg ttcgacggcg tgcgcggccg cggtcgcggc gaacggcgcc ccgttcacgg
    16921 cgtgggacaa cctgcgggtc gccggggtgg cagggcggga ccggcaggtg attccggacg
    16981 gccggctgtg cagcgggaac ctgcccgcgt accggggcct cgacctggcc cggcgggact
    17041 ggccggcgac ccggctgacg cccgggggcc ggctgacgat gacgtacgcc tcgacgatcg
    17101 cgcacgaggg cacgttccgg ctgtacctga ccaggcccgg ttacgacccg gcgaagccgc
    17161 tgaagtggtc cgatctgccg gagcgcccct tcgccgagat cacggaccca ccgctgcgga
    17221 gcggcgccta ccggttcggg gtgaagctgc ccgccgaccg gacgggccgt caggtgctgt
    17281 acacgatctg gcagaacagc agcacgccgg acacctacta ctcgtgctcc gacgtggtct
    17341 tcccgggggg cggtacggcg gccggggccg cgcgggccgc gggtacggcg ccggccccgg
    17401 cgtcccagaa gccgtcggcc cgggccggcg cgccctcggc cgagggcggt tccccggcga
    17461 agagcaagcc gtcggcggcg tcggccacgc cgtcggcgaa ggagcgtcca cgaaagagcg
    17521 acgccgccgc ggacgccgcc cccgtggcgg aggcgacgcg cggcggttcg ggcccctcgg
    17581 ccccgctgct ggcggccggt gccgccgcgg tgctggtgct caccgggggc gccgccctgg
    17641 ccctgcgtct gcggcggcgc tgaaccgcgc ctgacgcatc agttgacgta gaccggggct
    17701 ccgccgtcgg tgacgggcgc gtacttggcg gtgaagtagc cgttggcgaa gcacagcgac
    17761 gagccggagc tcttggtgaa ctgctggctg gtgaaggtga tgctgctgtc ggtgttgtcg
    17821 gccctgccgg tcagcccggc cgcccggtag acgcacgaga cgctgcccag cagggtgcgc
    17881 agcttgaccg tggcctggac gacggaaccg ctcggcggca ggacggagag ggtgccgtcg
    17941 gaggccaccg tcgccgtgta gggcaggttg tcgatggtga tgccgttgac cccgaggact
    18001 ccgatgacgt tgctggtgca gctgccgctg tcgaaggtgt gcgcggtgac ggactcggtg
    18061 gccgtgcccg gcgcgctcgg gttgtcggtg acggtcgccg tgaactggga ggacgcgcac
    18121 ttgacgccac tggtgccggt cgcgctggag tagaagttcg cggacgtgcc cgaggcgagg
    18181 ggcgcggtca gtacgtcgcc ggccgcgacg gccgtaccgc cggcgccgcc ggtggtgagg
    18241 acggcggcgc cgtcggcgga ggcgggtgcg gccacggtga gggcgagcgc ggtggcggtg
    18301 ccggcgagag ccagcaggga tcgcgtacgc atgcgggtgc ctctttcctg agtggggttc
    18361 ggacgaggtg acgtgcgctg tgcgggccgt acgggcgatg ccgccggcgc ggggccgtcg
    18421 cgccttctcc gtacgcgacg gacccacgac ggcggcaggc cgggcgccgc cggccggagg
    18481 tcccgggggt gaacctccgt ccggcgggcg ggacacgtgc ggacaccggc cggcccgggg
    18541 ggaaggagcc gtgccggatc cgcgacgggg aacgactgcg gtgcgggtgc gtgagcgatt
    18601 gccgtgaacc ggcgagggcg tcgcctgaca gggccgggaa cgcggccggt acctcccggc
    18661 ggacccggcg ccacggatcc gcggaaacag gtgaagttgt agacctgatg ctgcgtcaac
    18721 gtcaagcgtt gaaaaggcag ttgacggtgg cggacgcggg tcgcgcacat ccgacaccct
    18781 tttctcacat ctgtattgac cccttgctgt aaccggcggt aacttcctcg caggccgccc
    18841 ccacgccgtc agaaagccct tgcgtccgca gggagtgcga ggagtgcgtg agcggcagcc
    18901 gccgtccgcg ccaggacacc gcgccacgga agtccgatcc gcatcgcctt cacgcccctg
    18961 ggagcagaca tggcctcgtc cccggacgtc ccgtccgcag acagcacccc tgagaacccg
    19021 gacccgggtg cctcgtccga agtgccgggt gccgccgcca ccggcggcga gggcggcgag
    19081 aggcggggcc gcgtcagggc ccgccgggcg gcggtgatgg cggtgcccgc cacgctcgtc
    19141 ctcgcgggac tcgcggtcct caccgcgcag ggcgcgctcg gtgtgcagtt cgcgatctcc
    19201 ggcatgccgt tcacggtgac cgcgaccgag ctcgacggca ccggtttcga gcagttcggc
    19261 gggctcgaca ccatggcgga cggcagcccc aacgccgggg acaccggcgg ccaggtgctc
    19321 gtggtcacct ccgccatcaa gaacgccacc ctcaccaagc tgtgccagag cgtcgacctc
    19381 ggcggcacca acctgctgat caccgcgggc agtggtgcgg agaaggtcag cgcggccgac
    19441 ctcaccaccg actccaccga gctgacgggt gacgcggcgt tcggcaacat cgagatcggc
    19501 aacgacgcga gcacgctgac caaggcgggc gtgaaggggc cgatcggcgt cttcagccag
    19561 caggcggaca ccgtgcgcat cgcccatctt cggcagacca actacgcgac gacagccggt
    19621 gtgttcaagc tgcccggtct caagctccgt ttcagcgaat cgggttgctg accgccgtgc
    19681 cggaccgtcc acgccgggaa ccgaggctcg ccttccgcgg atggcgggcc cgccggccgt
    19741 tctggggcgg gctgctgctc gccctgggcg gcggcgagat cctgctcacc gagaaggcct
    19801 cgctgaaggt cgtgatgcac atcggcatgc agggcctggc cggctatctg ctgccgacgc
    19861 tgatggtgct gctgggcctg ctcgtcctcg tcaaccccac ccagcggctg ttctactccg
    19921 tcaccggcgt cctggtctcc ctgggcacct ggctcacctc caacctgggc ggcttcctcc
    19981 tcggccttct cctcggggtg gccggcagct gtctcacctt cggctggctg ccggaccagg
    20041 agccccgcgc cggccgccgc cgacgccggg aacgggcacg ggccgaacgg cgggcggcgc
    20101 gccgcccacg cgtgtctccg gggattcggt cctgatctcc ggaacttccc ggccgctctg
    20161 gaagtttcta cggtgctgta gaagttgctg tcggcgtgct gagcagccgg ccggggatac
    20221 gaggagtgcg catggccctg tgggaccgct tcaaggagtc ggcgtcgcag atgcagaccc
    20281 agttggtggc gaagaagaac gacctgaaga gcggcgcgtt ccgcgacgcg agcatggcga
    20341 tgtgcgccct ggtcgcggcg gccgacggga ccgtcgaccc gtcggagcgc cagcgggtgg
    20401 cccagctcat ctccaccaac gaggtgctgc agaacttccc cgcggacgac ctgcggcgcc
    20461 gtttcgagga gaacctggcc aagctgacga ccgatttcgc cttcggcaag gtgagcgtgc
    20521 tccaggaggt cgccaaggcg aagaagaagc ccgccgaggc gcgtgccgtc gtccagatcg
    20581 gcatcgtgat cggcggtgcc gacggcgact tcgacaagac cgagcaggcg gtcgtgcgcg
    20641 aggcctgcta cacgctggac ctgccgcccc acgagttcga cctctgatcc cggcctgacg
    20701 acgggacggg ggcccggacc acggtgtggt ccgcgccccc cgtcctcggt gcgcgacggt
    20761 gccggccggt ggccggcacc gcggggtcag tcgagcccgg cggacttcag ccaggccttg
    20821 gcgacgtcca gcgggtcctt gttctccgtc tgcacctggg tgtccaggtc cagcagggtc
    20881 gcggtgtcca gcttcgcgga gaccgcgtcg agcgcgtcgg cgcccttctg gttcagcgcg
    20941 cccttgtaga caagcggctg gacgttctcg aagccgaaga ggttcttcgg gtcctggagg
    21001 acgacgaact tctccttggc gatggtcgga tccgtggtga agaggtcggc ggcctgcacc
    21061 gcgtccttct tgagcgccgc ctgggtgagc gggccgcccg cgtccagcgc cttgaaggac
    21121 ttgaactgca ggccgtagac ggacttgagg cccaccaggc cctgctgccg ggtctggaac
    21181 tccggcgagc cgccgatgac caggtccttg gcgacgtcct tcagatcggc gatggacgac
    21241 ttctcggtga ggtggtactt cttcgcggtg gccgcgttga ccgtgaccga gtccttgttc
    21301 tgtgccgcgg agggcttcag cagggtcagc ttggagtcca gcttggcctc gatggcggtc
    21361 gtggtggcgt ccgcggtctt cggggtggcc ttcgggtcga gataggccag cagcgcgccg
    21421 ttgtactccg gcagcaccga gagggaaccg ttcttgatca ggccgtaggt cgtctcccgg
    21481 ctgccgatgt tcggcttgta ggtgaccttg atccccttgg ccttgagcgc ttcgccgtag
    21541 atgtcggcga gcagggtgct ctcggggaag ttgttggagc cgacgacgac gccgtcaccg
    21601 ctcgccttcc cctccgacag ggggtcgtcg gccttgtcgt tggaggagca gcccgccagc
    21661 agggccgtcg ccgccgccag ggcgacgacc gccgcgcctc ggttcctccg gatggacctg
    21721 ctgataaggg tcgtataagt cacttgctga tccaatccag cctgttctcg gtcagtcaag
    21781 tgcccagggg caccgattgg cctcgatctg tggtcagttg tgggtatagg gcggatgcct
    21841 tgtcacgacc tcttcacacg ggcccgggcc gtacgaatct cacgaggcct gtccgccggg
    21901 gcggtcggcg tcagccgctg cggcgcaccc cgggcgacac ggtgagccgg gaagccgccc
    21961 agaacacggc gagggtggcg agggcgaggc cggcgaccag ggtggcgccg cccacgacct
    22021 tctcgtagtt gcgctggtag aggccgtcga tgatgtagcg gccgagaccg ccgaggctga
    22081 cgtaggcggc gatggtcgcc gtggagacga tctggatcgc cgcggtgcgc agtccgctca
    22141 ggatcagcgg gagcgcgacc ggc
//
