LOCUS       NZ_LIWA01000005        22559 bp    DNA     linear   CON 28-MAR-2024
DEFINITION  Streptomyces sp. CB01883 scaffold5, whole genome shotgun sequence.
ACCESSION   NZ_LIWA01000005
VERSION     NZ_LIWA01000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CB01883
  ORGANISM  Streptomyces sp. CB01883
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 770318)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 770318)
  AUTHORS   Yan,X., Ge,H., Hindra,F., Yang,D., Huang,T., Crnovcic,I. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-AUG-2015) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2014
            Assembly Method                   :: CLC Genomics Workbench v. 7.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905855.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:34:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,089
            CDSs (total)                      :: 8,009
            Genes (coding)                    :: 7,788
            CDSs (with protein)               :: 7,788
            Genes (RNA)                       :: 80
            rRNAs                             :: 3, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 221
            CDSs (without protein)            :: 221
            Pseudo Genes (ambiguous residues) :: 0 of 221
            Pseudo Genes (frameshifted)       :: 85 of 221
            Pseudo Genes (incomplete)         :: 169 of 221
            Pseudo Genes (internal stop)      :: 25 of 221
            Pseudo Genes (multiple problems)  :: 50 of 221
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:33:31
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 500682
            Orig. end                         :: 523241
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LIWA01000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22559
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="3"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22559
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22559
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12559](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12559)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     gene            350..994
                     /locus_tag="AMK32_RS25005"
                     /old_locus_tag="AMK32_24565"
     CDS             350..994
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003981838.1"
                     /locus_tag="AMK32_RS25005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_24565"
                     /product="DUF1963 domain-containing protein"
                     /protein_id="WP_073896231.1"
                     /transl_table=11
                     /translation="MTTLMIDAGPSAADALVTRTGGLPLAPAGTEWPCCASCEGPMQFL
                     AQVLLDDRVEGPGEGGRGVLALFACQNDPGMCADWEPASGGNRALLFPVAGLGPLTRPD
                     GVEEEVLVLGAVRAVDLERGYGDEYEPAREAWAVESGRSESCVLGQLGGRPAWIQADET
                     PSCPACDRTMPLVVQLEEGPDHRSAMNFGGAGSAYAFACEPCGRASFLWQC"
     gene            complement(1042..1545)
                     /locus_tag="AMK32_RS25010"
                     /old_locus_tag="AMK32_24570"
     CDS             complement(1042..1545)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016433248.1"
                     /locus_tag="AMK32_RS25010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_24570"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_241841104.1"
                     /transl_table=11
                     /translation="MTKHIDPQGMNGRPCSLAATLEVVGDRWALPAIREVMLGNHRFRQ
                     IARNTGAPTDRLAARLKALVESGVLERRPLPDDARHHGYYLTEAGRDLAGVTRELIGWG
                     DRWAVTTPPVRFLHRDHALATHAVCDTCGEQVHAEDVHREELIPGWDRSGPVQPPSRRP
                     GPSR"
     gene            1641..3053
                     /locus_tag="AMK32_RS25015"
                     /old_locus_tag="AMK32_24575"
     CDS             1641..3053
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016433247.1"
                     /locus_tag="AMK32_RS25015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_24575"
                     /product="MFS transporter"
                     /protein_id="WP_241841106.1"
                     /transl_table=11
                     /translation="MATLVVLVAVFMTNLDLWIVNVALPAMGTAFSGGGAGATLGSLSW
                     VLNAYAITLAALLVVAGRAGDRMGQRPVFLAGIAVFTLASLGCALAPDLGTLVVARVVQ
                     AVGAAAQIPTSLALLLATVPAERRTHATRSWAAVGGLAAAAGPVAGGLLVEIDWRWVFA
                     VNVPIGIAAFVAGRSVLPRPTTREAGPLPDLLGALLVVSSVAALSGALVQAPDWGWTSG
                     GTVLLLAVAVIGGAGFVLRSLRHPHPLFELHLLRLPRFGAANAGSFLFGVAFAIMLLSN
                     VLWCQEVWHWSALRTGVALVPGPALVPVVTLLTARTAQRFGHGPLVAAGGLLFTAGMVW
                     RAGFASVDPDYLRDLLPSQVMTGTGVGLALGTLVAAGVHALPGHRAATGSALVNSVRQI
                     SATVGVAVLVAVVGSHVGAASRQDFRIAWYVAAVLSLATSVIGVRLSRGGGPARTAPVA
                     AKESEADTQALA"
     gene            complement(3263..3635)
                     /locus_tag="AMK32_RS25020"
                     /pseudo=""
     CDS             complement(3263..3635)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018891794.1"
                     /locus_tag="AMK32_RS25020"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSELGPGLWPPAPMRTERLLLRGSEARDRAAFVELFASPEVGAYT
                     GGPRPREELERVVPEVPGRRPGCFVVDLDGAAGGAPHPDRQLPGGAGGGEARVLGGGAV
                     RGVRRRAVARRADPGHPTGL"
     gene            complement(3683..4675)
                     /locus_tag="AMK32_RS25025"
                     /old_locus_tag="AMK32_24580"
     CDS             complement(3683..4675)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK32_RS25025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AMK32_24580"
                     /product="hypothetical protein"
                     /protein_id="WP_143611298.1"
                     /transl_table=11
                     /translation="MRSATVLLCLGLATATGCSNASSPSRPDAKPSGTVPGGRTATTGT
                     DWSVTFTASTAGAADGLDRTADRVRERVRTLGMTGTRVITEGTSLTVVGPYTAEQLQKL
                     GALGQLRFRPVLAQETAGSRTPTPGPSASPAQGRATTGALRADPAGSPQASASGGSDGT
                     SASLLAKFRALDCSAGSTHSESEQDTSPDSSAVACATDRSAGQPPSKYLLGPAILTGSE
                     LRSAKAVNDSTNGAGWMVQLDFTAAGAAKFADATARLAQNQSPQNEFAIVVDGGVVSAP
                     FVSQALTDGTAQISGSFTEKGARELAAKLNSGALPTPLRFAEATHVTER"
     gene            4836..5162
                     /locus_tag="AMK32_RS25030"
                     /old_locus_tag="AMK32_24585"
     CDS             4836..5162
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK32_RS25030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AMK32_24585"
                     /product="hypothetical protein"
                     /protein_id="WP_073896238.1"
                     /transl_table=11
                     /translation="MTGGDEQAQVLRYDRGAEDDDDRRRSRRGPILLTTLAVPAVGAAG
                     FQASSLRAGQGGNGILHLVVVVALLLIAFVVLALGIIWAINTVASLIGGIAAGRRRTRK
                     DVTR"
     gene            5276..5965
                     /locus_tag="AMK32_RS25035"
                     /old_locus_tag="AMK32_24590"
     CDS             5276..5965
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (1-162). E-value: 1.2e-12. Score:
                     40.0. Matches aSDomain:
                     nrpspksdomains_AMK32_RS25035_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003984982.1"
                     /locus_tag="AMK32_RS25035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_24590"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_073896239.1"
                     /transl_table=11
                     /translation="MGVHFITGAGSGIGAALAAAFAARGEELWLLARNEERARVLRARF
                     PRSRTPVADLAATGSLGGGLTEQELPARIDSLIHVAGVAESGTVAALGADVWQDTLAVN
                     VAAPAELTRLLLPALRAARGHVVFMNSGAGLHAPPRLSAYAASKFALKALAESLRAEEY
                     GSGIRVTTVYPGETDTPMQVRLHEQFGLPYDREAHMSPDSVAAAVLTALDLPRDTTMSD
                     LMLRPGR"
     aSDomain        5279..5761
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMK32_RS25035_PKS_KR.1"
                     /evalue="1.20E-12"
                     /label="AMK32_RS25035_PKS_KR.1"
                     /locus_tag="AMK32_RS25035"
                     /protein_end="162"
                     /protein_start="1"
                     /score="40.0"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="GVHFITGAGSGIGAALAAAFAARGEELWLLARNEERARVLRARFP
                     RSRTPVADLAATGSLGGGLTEQELPARIDSLIHVAGVAESGTVAALGADVWQDTLAVNV
                     AAPAELTRLLLPALRAARGHVVFMNSGAGLHAPPRLSAYAASKFALKALAESLRAEE"
     CDS_motif       5285..5350
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMK32_RS25035_0001"
                     /evalue="5.40E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="AMK32_RS25035"
                     /protein_end="25"
                     /protein_start="3"
                     /score="12.7"
                     /tool="antismash"
                     /translation="HFITGAGSGIGAALAAAFAARG"
     gene            complement(5901..7799)
                     /locus_tag="AMK32_RS25040"
                     /old_locus_tag="AMK32_24595"
     CDS             complement(5901..7799)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012998311.1"
                     /locus_tag="AMK32_RS25040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_24595"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_073896240.1"
                     /transl_table=11
                     /translation="MGDPTADAPHPQPETDRTARPPADLTDSAMRLVRGSLSHSRAAAV
                     RLTLWTLLHAAPALVAGKTLALAVDHGFLLHRPRTAALWLGVFALVTLAGAWASRQTYP
                     SLAEIVEPQRDRLLRDVVTGTLRRAVARGPRRRDDSAAVAVAQLTRQVEAVRDSLAGQL
                     MLVWQFVLTVAAVVAGTAAIAPGAVPLVAAPLVLALTVFAVLAPATVRRQRTAFVAEEV
                     LAHRTVSTLHALRDLVACGAAEKAEREMLDAIDAHLRASRALARLAAVRRMIVALGAHA
                     PLLLIVLAAPTLVRHGMTSGDVVGVVAYVLATLEPAVRLLIQGVGASWLRLAVAAERLS
                     AASRHPAPGTDPQPARTPVDGSAELSDLTFAYGPDAQPVLDGLDLSLADGDHLAVVGPS
                     GIGKSTMADVLAGILAPDRGQVLLGGVPLEHIARGDLHRARVLLPQDPYVFAGSVRENL
                     CYLAPDTPDDAVAAAVEQLGMARTVQRLGGLDAILTPAELSSGEAELIALARAYLSPAR
                     LVILDEATRHLDAVAEHRVEQAFRRRPGTVVTIAHRIAPARRADRVLLLDGVRPLTGTH
                     DTLLAAAPLYADLVGHWDTGVPGTDEACPGNTGRAVSAPASASDRSSSCPSADPAP"
     gene            complement(7879..9627)
                     /locus_tag="AMK32_RS25045"
                     /old_locus_tag="AMK32_24600"
     CDS             complement(7879..9627)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020127263.1"
                     /locus_tag="AMK32_RS25045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_24600"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_079192560.1"
                     /transl_table=11
                     /translation="MDSDRDRRGERAPGPGKGRVGESGRSDRFRRTPGARSWLWPTLLA
                     LAVTTGSLASLALPAVLARAVDQALSDGTGTGFLPLAAVLVLLTSTEATAQYAGPRATA
                     DETARLRRAMVRRVMAAGAFPPGRTAPGDLVARLTGSGAEAALATQAVVYAAAQLLMAV
                     GAVVALGLLAPELAAAFLVTAPAGYVLVRRHLRRTTQQGAGYQRAQGEVAARLVDALTG
                     SRTIAAAGTVDQEIARVMGPVPELSRCGRALWDSQRRVAWATGLLAPATQITVLASAGY
                     ELSVGRLSPGGLIAALGYATIGLGGFGTAQSLLDYARARAGRDRVADVLATPVQPPGTR
                     DLPPGPGLLELRGVTVRRSGRAVLDGLDLTLPAGSFVALVGRSGAGTSLLTAVAGGLLV
                     PDTGLALLDGVPMDDIRPDRLRTAVAFAFADPALTGDTVQDAVALAAEPVAADRVRAAA
                     RTAQADTFVRRLPETYLTPLAEAPLSGGERQRLGLARALARDSRLLVLDDATSSLDTTT
                     EALVLGAMAVTHRDRTRLMVTRRASTAARADAVAWLDEGRIRAFAHHDELWELPAYRSV
                     FRDGDD"
     gene            complement(9761..9904)
                     /locus_tag="AMK32_RS41535"
     CDS             complement(9761..9904)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012998309.1"
                     /locus_tag="AMK32_RS41535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_241841109.1"
                     /transl_table=11
                     /translation="MRWESNMSILGLQALETPEETTEYMSVISSLSAVNCTNSTVSTLL
                     CL"
     CDS_motif       complement(9836..9904)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MRWESNMSILGLQALETPEETTE"
                     /locus_tag="AMK32_RS41535_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9761..9835)
                     /prepeptide="core"
                     /locus_tag="AMK32_RS41535_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="5.40"
                     /molecular_weight="2344.7"
                     /monoisotopic_mass="2343.2"
                     /core_sequence="YMSVISSLSAVNCTNSTVSTLLCL"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRWESNMSILGLQALETPEETTE"
                     /leader_location="[9835:9904](-)"
                     /alternative_weights="2362.7"
                     /alternative_weights="2380.8"
                     /alternative_weights="2398.8"
                     /alternative_weights="2416.8"
                     /alternative_weights="2434.8"
                     /alternative_weights="2452.8"
                     /alternative_weights="2470.9"
     gene            complement(10001..12559)
                     /gene="lanKC"
                     /locus_tag="AMK32_RS25050"
                     /old_locus_tag="AMK32_24605"
     CDS             complement(10001..12559)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324972.1"
                     /locus_tag="AMK32_RS25050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_24605"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_073896241.1"
                     /sec_met_domain="micKC (E-value: 4.9e-277, bitscore: 916.8,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 1e-10, bitscore: 36.9,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="APH (E-value: 3.8e-08, bitscore: 29.0,
                     seeds: 156, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.6e-15, bitscore:
                     52.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDMRYEAYSYADKLFYDSPVRWATVEEFAAAGEPLPDGWVGRARD
                     VWVGRQPADLDLPEQGWKIHVSACLDNAEHILSVVSAYCFENRMAFKFLRSPALVQTQN
                     AKYASRGSSGKFMTLYPVGDDALERCLHDLGAALTGQQGPYILSDLRWREGPLHLRYGG
                     FTEHFCRSETGELVLAFREPSGRLRPDVRRAVFEVPDWAPVPAVLAQALADQSRASMAD
                     FPYTVERALHFSNGGGIYVGRPVGGGDHVVLKEARPHAGLDQRGDDAVLRLGRERDILD
                     RLAGLSAVPAALDYLTAWEHHFLVQEYVQGEPLNRWFGQRYPLVHPDPDEETVIRYREE
                     AQAVLASIEEGLRAIHERGVVFGDLHPRNLIVGPDGRVTFIDFELASLAAEFVRPALGA
                     AGFAAPPELEGFAVDAYALDALRLWIYMPLMQLTSLDPGKRAELTSAAAGRFQLPSPHL
                     PDPPGDPERAGLTALLRGDSAMWPALRDSMTAAIHASATPERTDRLFPGDPAQFTHDGL
                     GLAYGAAGVLWALHSTGAEVDPDHVQWLLDAVPREPCRPGLFIGSHGVAYALDRLGHAP
                     QAQRLLDRLLQDPPDGHGTDLAGGLPGIGLTLLHFAGTTGDSRLHSAALDTAERLAARL
                     KPADASGDPTPGRRTGLMYGTTGAALFFLRLYESTADTGLLDLAEQALEQDLAHCVLTD
                     DGTLQVDDGTRVLPYLESGSAGIAAVLHDFLRHRPDPELRQHVERIRLAAEPEFIVQPG
                     LFNGRAGLISLLHTLQDGTEVHGQVIRRHIRRLAWHLIPYQGHVAFPGEQLLRLSMDLA
                     TGSAGILLALGSALADTPALPFLTAERADKPASAPVLQAP"
     misc_feature    complement(12110..12112)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(12455..12457)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(12769..12782)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.85"
                     /tool="antismash"
     misc_feature    12770..12783
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.19"
                     /tool="antismash"
     misc_feature    12883..12898
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.01"
                     /tool="antismash"
     misc_feature    12908..12923
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.86"
                     /tool="antismash"
     gene            12914..13588
                     /locus_tag="AMK32_RS25055"
                     /old_locus_tag="AMK32_24610"
     CDS             12914..13588
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014677016.1"
                     /locus_tag="AMK32_RS25055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_24610"
                     /product="HEAT repeat domain-containing protein"
                     /protein_id="WP_073896242.1"
                     /transl_table=11
                     /translation="MAISTQEPDAERALQGLEDGRASVRLRAALALGTAPEPRFVDKLV
                     QRSAVEPEFFVRDMLTWALTRHPVDTTLPALLREVRAKSAQARSQALHTLSKIGDPRAW
                     PAITRTLLSDPDIEVARSAWRAAAVLVPEGEEHALATVLVTQLGRGGRETHLSLSRALV
                     ALGDVPPLLAATTAPDPVVRAHALATRRLLRDPDAGFACAIEEAKRVVALGGPGQEGRQ
                     AC"
     gene            13582..14676
                     /locus_tag="AMK32_RS25060"
                     /old_locus_tag="AMK32_24615"
     CDS             13582..14676
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007457518.1"
                     /locus_tag="AMK32_RS25060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_24615"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_079192561.1"
                     /transl_table=11
                     /translation="MLIGEVARRSGVSARMLRHYESLGLVRPSGRTVSGYREYSGEDIQ
                     RIFHVESLRSLGLSLREIGRALDDPGFTPPALVEDLIGRTRERIAAETELLTRLCRIDA
                     TDPTGWEDVLQVVALLQALESTSAGTRQRAALSSAHDVTVPVEALVEAALGESDANVAG
                     ALRWALARTGDPGSALLAEGLGSPVAAVRERAVRALAEIPGDETTTRLRDALANHDVVV
                     RRYAALALGTRGVADAVPTLVDMVVDGSNDTDAADVLSVLAGDTGTADRIASALVDLLT
                     HGTTGAPARGRLTQALAGIPGTRASTALAELSHDPDRAVALTAAYVLRLRGDMGGDMRT
                     VQPASRSRAFSEGDPGSTVYRPSV"
     gene            complement(14604..15434)
                     /locus_tag="AMK32_RS25065"
                     /old_locus_tag="AMK32_24620"
     CDS             complement(14604..15434)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014175566.1"
                     /locus_tag="AMK32_RS25065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_24620"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_073896243.1"
                     /transl_table=11
                     /translation="MSELAPETALREFLRTRRARLTPEQTGLPAHPGLPRSPGLRREEV
                     AQLAGVSADYYVRLEAGRGAGVSPSVLRAVARALQLDDTERDHLFALVEGVRQRPHAVV
                     EQQARLGLVRALDNIGDVPALLLGHRLDVLATNRLARALHLDFDGRPAEEWNMARYMFL
                     SEAARELCVDWAETAREIVGMLRLYAGHHPHDPTLDQLVSDLSADDRDFRDWWAGPEVY
                     LPRYGVQRYRHPLAGDLTLGFEVFTPLGDDDQTLGLYTVEPGSPSEKALLLLAG"
     gene            complement(15731..15886)
                     /locus_tag="AMK32_RS42725"
     CDS             complement(15731..15886)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014677068.1"
                     /locus_tag="AMK32_RS42725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_185091513.1"
                     /transl_table=11
                     /translation="MPGVLQRLKEFARSPQGQRTIEQARRTAADPRRRAQAQRLFGKLR
                     ARRSGM"
     misc_feature    complement(15928..15939)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     misc_feature    complement(16170..16188)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 21.42"
                     /tool="antismash"
     misc_feature    complement(16258..16269)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     gene            16346..16621
                     /locus_tag="AMK32_RS25070"
                     /old_locus_tag="AMK32_24625"
     CDS             16346..16621
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013518.4"
                     /locus_tag="AMK32_RS25070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_24625"
                     /product="alpha-amylase"
                     /protein_id="WP_158075351.1"
                     /transl_table=11
                     /translation="MSLTLPFALAEPASARSESPEPAPACVAMYESWRYTQAANDCADT
                     VALKVVYQDGATGPCHTLPPGAISTVGEGYLGLHGHADHLAVCALD"
     gene            complement(16644..16856)
                     /locus_tag="AMK32_RS25075"
                     /old_locus_tag="AMK32_24630"
     CDS             complement(16644..16856)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014677069.1"
                     /locus_tag="AMK32_RS25075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_24630"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_073896244.1"
                     /transl_table=11
                     /translation="MHKGKWITGSARKDLARTFTEEYGEGRSIRAIAEAHGRSYGFVHR
                     VLTEAGAPLRARGGDARSGAAKSTR"
     gene            17117..18166
                     /locus_tag="AMK32_RS25080"
                     /old_locus_tag="AMK32_24640"
     CDS             17117..18166
                     /EC_number="1.14.19.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0016717 - oxidoreductase activity, acting
                     on paired donors, with oxidation of a pair of donors
                     resulting in the reduction of molecular oxygen to two
                     molecules of water [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) delta12_cd03507"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014151972.1"
                     /locus_tag="AMK32_RS25080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_24640"
                     /product="acyl-CoA desaturase"
                     /protein_id="WP_241841162.1"
                     /sec_met_domain="delta12_cd03507 (E-value: 4.5e-13,
                     bitscore: 44.3, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVSASAAEQRGLAGNGSDFARLSQRIAAAGLMRRRPGYYTARIG
                     LVVALYAAGWGAFFLLGDSWGQLAVSAFLAFVFGQVALLAHDLAHRQIFGRRRPSEIMG
                     RLFGNLGVGMSYGWWMNKHTRHHANPNHEDLDPDVAPDILVWSTDQARASRGVARVIGG
                     HQALLFFPLLTLEGFNLHVSSLRALRAPYMKKRALEGALLLLHIAGLLSALFLILSPGK
                     ALAFLALNQCLFGVYLGCTFAPNHKGMPTFTGDERPDFLRRQVLTSRNVRGGRLTDVML
                     GGLNYQIEHHLFPSMPTPHLRRARTVVRQYCAEIGVAYHETGLIRSYREALAHLHRVGE
                     PIRRQRRAR"
     gene            complement(18257..18676)
                     /locus_tag="AMK32_RS25085"
                     /old_locus_tag="AMK32_24645"
     CDS             complement(18257..18676)
                     /NRPS_PKS="Domain: Polyketide_cyc2 (0-137). E-value:
                     7.2e-30. Score: 96.2. Matches aSDomain:
                     nrpspksdomains_AMK32_RS25085_Polyketide_cyc2.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009071066.1"
                     /locus_tag="AMK32_RS25085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_24645"
                     /product="SRPBCC family protein"
                     /protein_id="WP_073896246.1"
                     /transl_table=11
                     /translation="MASTSVSRVLPASPQQVWDLIGGFDALPDWLPFIRESTPLEGGRV
                     RRLTNPDGDVITERLIAYSEAERSYSYAIVDAPFPVTGYLSTLRVHPVAGRDDVAEVQW
                     SGRFTPDGVSDAEAEDLFAGIYRDGLEALRETLTA"
     aSDomain        complement(18266..18676)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMK32_RS25085_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="7.20E-30"
                     /label="AMK32_RS25085_Polyketide_cyc2.1"
                     /locus_tag="AMK32_RS25085"
                     /protein_end="137"
                     /protein_start="0"
                     /score="96.2"
                     /tool="antismash"
                     /translation="MASTSVSRVLPASPQQVWDLIGGFDALPDWLPFIRESTPLEGGRV
                     RRLTNPDGDVITERLIAYSEAERSYSYAIVDAPFPVTGYLSTLRVHPVAGRDDVAEVQW
                     SGRFTPDGVSDAEAEDLFAGIYRDGLEALRETL"
     gene            complement(18731..19741)
                     /locus_tag="AMK32_RS25090"
                     /old_locus_tag="AMK32_24650"
     CDS             complement(18731..19741)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669605.1"
                     /locus_tag="AMK32_RS25090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_24650"
                     /product="aldo/keto reductase"
                     /protein_id="WP_073896247.1"
                     /transl_table=11
                     /translation="MSLTDLIPGRLGFGTAPLGNMFRAIPDDEARATVEAAWDHGIRFY
                     DSAPFYGAGLAEQRLGEVLAGKPRDSYVLSTKVGRVILDEHETSARDLGEKGGLFEHGN
                     PNKIVHEWTAEATERSIEDSLKRLRTDRLDIVWVHDIAQDFLGDLWLQKFEEARTGAFR
                     VLSRLRDEGVIKAWGLGVNRTEPIELTLALDEPRPDGFLLAGRYTLLDHGHALQRLLPL
                     AQEQGVGMVVGGPYSSGVLAGGTHFEYQQAPAEIIERVGRLKDLAAQHGVGIKAAALQF
                     SLAHPAAVAVIPGATRPSRTAEDTAALDEHIPAAFWADLRAAGLVSPAAPLPPGA"
     misc_feature    complement(19735..19750)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.86"
                     /tool="antismash"
     misc_feature    complement(19873..19886)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.87"
                     /tool="antismash"
     misc_feature    complement(19990..20005)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.15"
                     /tool="antismash"
     gene            complement(20063..20683)
                     /locus_tag="AMK32_RS25095"
                     /old_locus_tag="AMK32_24655"
     CDS             complement(20063..20683)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027: isochorismatase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009882017.1"
                     /locus_tag="AMK32_RS25095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_24655"
                     /product="isochorismatase family cysteine hydrolase"
                     /protein_id="WP_073896827.1"
                     /transl_table=11
                     /translation="MTDRYDTGRTAVLLVDPYNDFLSEGGKLWSRLAPVADEVGLLRNL
                     RAVVDAARTAGLLVAFVPHRRYEEGDYVGWDHPNPTQRKARRLRLFARDSWGGEFHPDF
                     QPRPGDLRIAEHWAQSGFANTDLDCRLKQHGVTHVILIGLLANTCVESTGRFAMELGYH
                     VTLVTDATAAFSADMLRAAHELNGPTYAHAIVTTAELVHTLSG"
     misc_feature    complement(20687..20696)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            20918..21274
                     /locus_tag="AMK32_RS25100"
                     /old_locus_tag="AMK32_24660"
     CDS             20918..21274
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669327.1"
                     /locus_tag="AMK32_RS25100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_24660"
                     /product="hypothetical protein"
                     /protein_id="WP_073896248.1"
                     /transl_table=11
                     /translation="MRKIMTGTATTLLAAAVLCTGSPAQALDGTRAAPEASGFCGTDPA
                     SGLAVWGDRADACAAALAVASAYTKAAAGTAKGPGTVRAGGATWKCQERQGDPNPYQEC
                     VDASDSGRRVVLSS"
     misc_feature    complement(21904..21915)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     misc_feature    22360..22376
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.81"
                     /tool="antismash"
ORIGIN
        1 ctttcgcgtg cggtgatccc aagggtgtcg gcccccgact gttcttccag cgggttcccg
       61 agggcaaggt cgtcaagaac cgggtacatc tcgacgtgcg ggtcggcacc gggctggtgg
      121 gtgaagagcg cctcgccgta ctccaggccg agtgcgatcg gctggtcgcg ctcggcgcgg
      181 tccgcgagcg agtgctcctc gccgacgact acaacgagtc gtgcatcgtg atgcaggacg
      241 tcgagggcaa cgagttctgt ctcgactgag cccgcacccc cggagacggc gaggtgggtg
      301 ccgtcttcgg gggatcagca cacagggtgc ggccccttac agttcggcca tgacgaccct
      361 gatgatcgat gccggaccgt ccgcggcgga tgcgctggtg acccggaccg gcggactgcc
      421 cctggccccg gccggtacgg aatggccctg ctgcgcgtcg tgcgaaggtc cgatgcagtt
      481 cctcgcccag gttcttctgg acgaccgggt agaagggccg ggggagggcg ggcggggcgt
      541 tctcgccctg ttcgcgtgtc agaacgaccc gggaatgtgc gccgattggg agccggcctc
      601 cggcgggaat cgagccttgc tcttcccggt cgccggcctc gggccgctga cccggcctga
      661 cggcgtcgaa gaggaagtgc tcgtgctggg cgccgtacgg gccgtggacc tcgagcgcgg
      721 gtacggggac gagtacgaac cggcccgcga ggcgtgggcg gtggaaagcg gacgctccga
      781 gtcctgcgtc ctcgggcagc tcggcggacg tcccgcctgg atacaggccg acgagacgcc
      841 gtcctgtccc gcgtgcgacc gcacgatgcc cttggtcgtc cagctcgagg aagggccgga
      901 tcaccgctcc gccatgaatt tcggcggggc gggcagcgcg tacgccttcg cctgtgagcc
      961 ctgtgggcgc gcgtcgttct tgtggcagtg ctgagacggc ggtgctgagg cgcacgcgga
     1021 cgagtccgcg gtggtgcggc tctaccggga cggccccggc cgccggctcg ggggctgtac
     1081 cgggccggag cggtcccagc cggggatcag ctcctcccga tggacgtcct ctgcgtgcac
     1141 ctgctcgccg caggtgtcac agaccgcgtg ggtggcgagt gcgtggtccc ggtggaggaa
     1201 gcgcacgggg ggcgtggtga cggcccagcg gtcgccccag ccgatgagct cgcgggtgac
     1261 gcccgccagg tcccgtcccg cctccgtcag gtagtagccg tggtggcgtg cgtcgtccgg
     1321 cagcgggcgc cgttcgagga caccgctctc caccagcgct ttcaaccgcg ccgccagacg
     1381 gtcggtgggg gcgccggtgt tcctggcgat ctgccggaag cggtggttcc cgagcatcac
     1441 ctcgcggatc gccggcaggg cccagcggtc gccgaccact tccagggtgg cggcgagcga
     1501 gcacgggcgt ccgttcatgc cctgcggatc gatgtgcttg gtcacctagc cagtatcacc
     1561 ctgaggggtt tgatttccaa accatctcat gcttggcttg cgccatgccc atgatgcttc
     1621 gattttcaaa gcaccctcgc atggccacac tggtcgtcct ggttgccgtc ttcatgacca
     1681 acctggatct gtggatcgtc aacgtcgcgc ttccggccat ggggacggcg ttctccgggg
     1741 gtggcgcggg tgcgaccctc ggttcgctgt cctgggtcct caacgcctac gcgatcaccc
     1801 tggcggccct tctggtggtg gccgggcgcg ccggtgaccg catggggcag cggccggtct
     1861 tcctcgccgg gatcgccgtc ttcaccctcg cgtcgctggg ctgtgccctg gcgcccgacc
     1921 tggggaccct cgtggtggcc cgagtggtgc aggccgtcgg ggcggccgct cagattccca
     1981 cgtccctcgc cctgctgctc gcgacggtgc cggccgagcg tcgtacccac gccacccgga
     2041 gctgggccgc ggtcggcgga ctcgcggcgg ccgccggacc cgtcgccggt ggtctcctgg
     2101 tcgagatcga ctggaggtgg gtcttcgccg tcaacgtgcc catcggcatc gcggcgttcg
     2161 tcgcgggccg atcggtcctg ccgaggccga ccacccggga ggccggaccg ctcccggacc
     2221 tcctcggcgc actgctggtg gtctcctcgg tcgctgcgct gtccggagcg ctggtgcagg
     2281 cgcccgactg gggctggacc agtggcggga ccgtcctgct cctggccgtc gccgtgatcg
     2341 gcggcgccgg gttcgtcctc aggtccctgc gtcacccgca cccgctgttc gaactgcacc
     2401 tgctgcggct gccgcgcttc ggagcggcga acgcgggcag cttcctgttc ggcgtcgcct
     2461 tcgcgatcat gctgctgtcc aacgtgctgt ggtgccaaga ggtctggcac tggagcgcgc
     2521 tgcgtaccgg tgtcgccctg gtgcccggtc ccgccctcgt cccggtcgtc accctgctga
     2581 ccgcccgcac cgcgcagcgc ttcgggcacg gcccgctggt cgccgcgggc ggactgctgt
     2641 tcaccgcagg catggtgtgg cgggcgggct tcgcgtccgt cgacccggac tatctgcgtg
     2701 acctgctgcc gagccaggtg atgaccggca cgggtgtcgg gctggccctg ggcacgctgg
     2761 tggccgccgg tgtgcacgcc ctgccggggc accgcgcggc gaccggatcg gcgctggtca
     2821 actccgtccg tcagatatcg gccacggtcg gcgtcgccgt cctcgtcgcg gtggtcggtt
     2881 cgcacgtcgg tgccgcctcc cgccaggact tccggatcgc ctggtacgtg gccgccgtgc
     2941 tgagcctggc gacgtcggtg atcggcgtgc gcctcagccg cggcggcggc ccggcccgga
     3001 cggcgcccgt cgccgcgaag gagtccgagg cggacacaca ggctctggcc tgatcacgct
     3061 cacccacgag gttccgcttc ggggagttca cggtcatccc gaccacggcg gcggccgagg
     3121 tggaccgcct tcaagaccga gatcgacggg gtggtgtgag ggcgaccgtc gtcgccctcg
     3181 acctcctgcg ctgccgacgc ggcggggccg gtggcgcgta gccggtcgcg cgcgtccccg
     3241 ccggctgcgg aggggacgca cctcagcccg gtgggatggc cggggtccgc gcgccgagcc
     3301 actgctcggc gccgtactcc tcgtaccgct ccacctccga gaacccgagc ttcgccgcca
     3361 cccgcaccgc ccgggagttg gcggtctggg tgcggagcac caccggctgc tccgtcgagg
     3421 tcgaccacga agcaaccggg gcggcggccg ggtacctcgg gcaccacgcg ttcgagctcc
     3481 tcacggggtc gagggccacc ggtgtaggca cccacctccg gtgaggcgaa cagctcgacg
     3541 aacgccgcac ggtcccgggc ttcggacccg cgcagcagga gccgttcggt cctcatcggc
     3601 gcaggcggcc agagaccggg tccgagttca ctcatggcgg gcaacctatc gcagggcctt
     3661 tggagtgagc cgaggacgca cctcagcgct cggtgacatg tgtcgcttcg gcgaacctca
     3721 acggagtggg cagcgcaccg gagttcagct tggcggccag ctcccgtgct cccttctcgg
     3781 tgaagctgcc ggagatctgc gcggtaccgt cggtgagcgc ctggctgacg aagggcgcgg
     3841 acaccacgcc accgtccacg acgatggcga actcgttctg cggcgactgg ttctgcgcaa
     3901 gccttgcggt cgcgtcggcg aacttcgcgg ctcccgcggc cgtgaagtcc agttgcacca
     3961 tccagcccgc cccgttcgtg ctgtcgttca ccgccttggc tgatctgagt tcgctgcccg
     4021 tgagaatggc cggcccgagc aggtacttcg agggtggttg gcccgcggag cggtcggtgg
     4081 cacaggcgac ggcggagctg tcggggctcg tgtcctgttc ggactcggag tgcgtggacc
     4141 cggcggagca gtccaatgcc cggaacttcg ccaggaggga ggcggacgta ccgtcggacc
     4201 cgccggaggc actggcctgc ggggaaccgg cagggtcggc ccggagtgcc cccgtggtcg
     4261 cgcgcccctg tgcggggctg gcgctgggcc cgggcgtggg tgtccgggag ccggcggtct
     4321 cctgcgccag caccggccgg aagcggagtt gccccagagc gccgagcttc tgcaactgct
     4381 cggccgtata gggtccgacg acggtgaggg acgtgccctc ggtgatgacc cgggtgcctg
     4441 tcatcccgag agtgcggacc cgttcccgca ctcggtcggc ggtgcgatcc agtccgtccg
     4501 cggccccggc cgtcgatgcg gtgaaggtca ccgaccagtc ggtgccggtg gtggccgtcc
     4561 ggccgccggg cactgtgccg gacggcttcg cgtccggccg ggacggggac gacgcattcg
     4621 agcagccggt cgcggtggcc aggcccaggc acagcagaac ggtcgcgctt ctcacgtgaa
     4681 gggtatgcac ggtgtgcagc ctcccagccg taatgccggg tgtgcaggca aatggccgac
     4741 tctcgggcgg cccgctcggc cagacgttaa tcttgttcgg ccctgtgggc cgcccgggcc
     4801 gacgcgaggg cgcggtgaga ctgcacaatc attctgtgac gggtggggac gagcaggcgc
     4861 aggtactccg gtacgaccga ggggcggagg acgacgacga ccgccgacgg tcgcggcgtg
     4921 gcccgatcct gctcaccact ctggccgtcc cggccgtcgg agccgccggt ttccaggcga
     4981 gctcgctgcg ggccggacag ggcggaaacg gcatcctgca cctggtggtg gtcgtcgccc
     5041 tgctcctcat cgccttcgtg gtgctggcac ttggcatcat ctgggccatc aacaccgtcg
     5101 cgtccctgat cggcgggatc gccgccggtc ggcgcaggac gcgcaaagac gtcactcgct
     5161 agcccggtcc cgcccgacga cgcaccggac ctgcccttac ccaacgccgt tcatttcagg
     5221 ccgaactgac caaggctcag tgacttacgg ccccatcatg ggtacatacc atgccatggg
     5281 cgtacatttc atcacaggtg ccggttcggg tatcggggcg gccctggccg cggctttcgc
     5341 ggccaggggt gaggagttgt ggctgctggc gcgcaacgag gagcgggcgc gggtactgcg
     5401 ggccaggttt ccccgcagcc ggacaccggt ggcggacctg gccgccacgg ggtcgctcgg
     5461 cggtgggctg accgagcagg aactgcccgc tcggatcgac tcgttgatcc atgtcgccgg
     5521 cgtcgcggag tccgggacgg tcgcggcact cggggcggac gtctggcagg acacgctcgc
     5581 ggtcaacgtg gccgcaccgg cggaactcac ccggctgctg cttcccgcac tgcgcgcggc
     5641 acgcggtcac gtcgtgttca tgaactccgg tgcgggtctg cacgcgccgc cacgactgag
     5701 tgcctacgcg gcgtcgaagt tcgcgctgaa ggcactcgcc gagtcgctca gagccgagga
     5761 gtacggcagc gggatccggg tcaccaccgt ctacccgggc gagaccgaca ccccgatgca
     5821 ggtccgcctg cacgagcagt tcggcctccc ttacgaccgc gaagcccata tgagcccgga
     5881 ttccgtcgcc gccgccgtgc tcacggcgct ggatctgccg agggacacga cgatgagcga
     5941 tctgatgctg aggccggggc gctgaccgcg cggccggtgt tcccgggaca cgcctcgtcc
     6001 gtcccgggaa ccccggtgtc ccagtgaccg accagatcgg cgtagagggg cgcggccgcc
     6061 agcagcgtgt catgggtacc ggtgagtggc cgtacgccgt ccaggagcag cacccggtcc
     6121 gcccggcggg ccggagcgat ccggtgggcg atcgtcacca ccgtccccgg ccggcgccgg
     6181 aacgcctgct cgacgcggtg ttcggccacc gcgtcgaggt ggcgggtcgc ctcgtcgagg
     6241 atgaccagtc tggctgggga caggtaggcc cgggccaggg cgatcaactc cgcttcgccc
     6301 gaggacagtt cggccggagt gaggatcgcg tcgaggccgc cgagccgctg caccgtacga
     6361 gccataccga gctgctcgac ggccgcggcg acggcgtcgt cgggagtgtc cggggcgagg
     6421 tagcacaggt tctcccgtac cgatccggcg aagacgtagg gatcctgggg cagaagcacc
     6481 cgggctcggt gcagatcgcc gcgcgcgatg tgctccaggg ggacgccgcc gagcaggacc
     6541 tgtccgcggt cgggggccag tattccggcg aggacgtccg ccatcgtgga cttgccgatc
     6601 ccggaagggc cgacgacggc caggtggtcg ccgtcggcga gcgagaggtc gagcccgtcg
     6661 agcaccggtt gcgcgtccgg cccgtacgcg aaggtgaggt ccgacagttc cgccgaaccg
     6721 tccacgggcg tccgtgcggg ctgcggatcg gtgcccggcg cgggatgccg tgaggccgcg
     6781 gacaggcgct cggcggccac ggcgaggcgc agccaggagg cgccgacgcc ttggatcagc
     6841 aggcggacag cgggttcgag ggtggccagc acataggcga ccacgcccac gacgtcgccg
     6901 gacgtcatac cgtgccgcac cagggtcgga gcggcgagga cgatcagcag gagcggggcg
     6961 tgggcgccca gtgccacgat catcctgcgt accgccgcca gccgcgcgag ggcccgcgac
     7021 gctcgcaggt gggcgtcgat cgcgtccagc atctcgcgtt ccgccttctc cgcggcgccg
     7081 cacgcgacga ggtcgcgcag cgcgtgcagg gtcgagacgg tgcggtgggc caggacctcc
     7141 tccgcgacga acgcggtgcg ctgcctgcgg acggtcgcgg gggccaggac ggcgaacacg
     7201 gtcagggcga gcaccagcgg tgcggcgacg agggggaccg cgcccggggc gatggcggcg
     7261 gtgccggcca cgaccgcggc cacggtgagg acgaactgcc acacgagcat cagctgaccg
     7321 gcgagcgagt cacggaccgc ctccacctgg cgggtgagct gggcgaccgc gacggcggcg
     7381 gagtcgtccc gccgccgggg gccccgtgcc accgctcggc gcagggtccc cgtgacgacg
     7441 tcgcgcagca ggcggtcgcg ctggggttcc acgatctcgg ccagcgacgg gtaggtctgc
     7501 cggctcgccc aggccccggc gagggtcacc agggcgaaca caccgagcca cagcgccgcc
     7561 gtcctcggcc ggtgcaggag gaagccgtgg tcgacggcca gggcgagcgt cttgccggcg
     7621 accagtgcgg gcgcggcgtg gagcagtgtc cacagggtca ggcgcacggc agcggctcgg
     7681 ctgtgcgaca gactgccccg gaccaggcgc atcgcgctgt ccgtgaggtc ggcgggtggt
     7741 cgggcggtcc ggtcggtttc cggctggggg tgcggtgcgt cggccgtggg gtcgcccact
     7801 ggcggtctcc tttcgtccgg tcgcgtccgc cgtccgccgc cgcggagacg gtgcgccgct
     7861 gcacgcggtg acggtgcgtc agtcgtcgcc gtcgcggaac acgcttcggt aggcggggag
     7921 ttcccacagt tcgtcgtggt gggcgaatgc ccggatgcgc ccctcgtcga gccatgccac
     7981 ggcatcggcg cgggcggccg tcgaggcgcg gcgggtcacc atcagccggg tgcggtcccg
     8041 gtgggtcacg gccatcgcgc cgaggaccag ggcctcggtg gtggtgtcga gactcgatgt
     8101 cgcgtcgtcg aggacgagca gccggctgtc ccttgccaag gcccgtgcca ggcccagccg
     8161 ttgacgctca ccgcccgaca gcggagcctc cgccagcgga gtcaggtagg tctcgggaag
     8221 ccggcggacg aaggtgtccg cctgtgccgt gcgggccgcg gcgcgcacgc ggtcggcggc
     8281 gaccggctcc gcggcgagag ccacggcgtc ctgcaccgtg tccccggtca gcgccgggtc
     8341 ggcgaaggcg aaggcgacgg cggtccgcag ccggtcgggc cggatgtcgt ccatggggac
     8401 gccgtcgagc agggcgaggc ccgtgtcggg gaccaggagt ccgccggcca cggcggtgag
     8461 cagcgaggtg cccgcgccgg agcgaccgac gagtgcgacg aaactcccgg ccgggagcgt
     8521 gaggtccagc ccgtccagga cggcacggcc ggaccggcgc acggtcaccc cgcggagttc
     8581 gaggagtccc gggcccggcg gcagatcgcg tgtgcccggc ggctggacgg gcgtggcgag
     8641 cacgtcggcg acacggtcgc ggcccgcgcg ggcccgcgcg tagtccagca gactctgtgc
     8701 cgtaccgaac ccgccgaggc cgatggtggc gtaaccgagc gcggcgatca ggccgcccgg
     8761 gctcagccgt ccgacggaca gctcgtaccc ggcgctggcg agcacggtga tctgcgtggc
     8821 cggggcgagg agtccggtgg cccaggccac gcggcgctgg ctgtcccaca gggcgcgccc
     8881 gcaccgggag agctcgggca caggacccat gacccgcgcg atctcctggt cgaccgtgcc
     8941 ggcggccgcg atggtacggc tgcccgtgag cgcgtccacc agccgtgccg ccacctctcc
     9001 ctgcgcgcgc tggtagccgg cgccctgctg tgtcgtacgc cggagatggc gtcgcaccag
     9061 cacatagccc gccggtgcgg tgacgaggaa ggcggcggcg agttccgggg cgagcaggcc
     9121 caacgcgacc acggcgccga cggccatgag gagttgggcg gccgcgtaca ccaccgcctg
     9181 tgtggcgagg gccgcctccg cgccgcttcc ggtgagccgc gccaccaggt cgcccggtgc
     9241 ggtccggccc ggcggaaacg caccggccgc catgacgcgc cgtaccatcg cgcggcgcag
     9301 gcgtgccgtc tcgtcggccg tggcacgcgg gccggcgtac tgcgccgtcg cctcggtgga
     9361 ggtgagcaga acgaggacgg cggccagcgg caggaagccc gtgccggtgc cgtcggacag
     9421 ggcctggtcg acggctcgcg cgagcaccgc gggcagggcc aggctcgcca gggaaccggt
     9481 cgtcaccgcc agtgccagca gggtgggcca cagccaggaa cgtgctccgg gcgtgcggcg
     9541 gaaccggtcc gaccggccag actcgcccac ccggcccttg ccgggtccag gggcccgctc
     9601 gccacggcgg tcgcggtcgc tgtccatgca tgcctcctcg gtgggccggc cggaatgggg
     9661 ccggacacga gacggagccg gtccgggctg cgatgcagtc cggaccggcc gtgctacccg
     9721 ggtcagtcgg cggcgcctgt ggctgacccg gtcgcgtcca ctagaggcag agcagggtgc
     9781 tgacggtgct gttggtgcag ttgaccgcgc tcagcgagct gatcaccgac atgtactcgg
     9841 tggtctcttc gggggtctcc agtgcctgca ggccgaggat cgacatgttg ctctcccatc
     9901 gcatggtgtg gtgctcctgc tttccggcga ttaccggaaa cctgtggacc gcggtgcggt
     9961 cgtcgcggcg ggccgccgct gtcttgcgtg gatcagtcgc tcagggcgcc tgcaggaccg
    10021 gggcggacgc cggcttgtcg gcccgctcag cggtcaggaa gggaagggcc ggggtgtcgg
    10081 cgagcgccga gcccagcgcc aggaggatgc cggccgagcc ggtggccagg tccatggaca
    10141 gccgaagcag ctgctcgccg gggaaggcga cgtggccctg gtaggggatg agatgccagg
    10201 cgagccgccg gatgtgccgt cggatgacct ggccgtggac ctcggttccg tcctgcagcg
    10261 tgtgcagcag cgagatcagt ccggcacggc cgttgaacag ccccggctgg acgatgaact
    10321 cgggttccgc ggcaaggcgg attcgttcga cgtgctgccg cagctccggg tccggacggt
    10381 ggcgcaggaa gtcgtggagc acggcggcga tgccggcgct gcccgattcg aggtacggca
    10441 gcacccgggt gccgtcgtcg acctgcaggg ttccgtcgtc ggtcaggacg cagtgggcga
    10501 ggtcctgctc cagcgcctgt tccgcgagat cgagcaggcc ggtgtcggcg gtgctctcgt
    10561 agaggcggag gaagaacagg gcggcgccgg tggtgccgta catgagcccg gtgcgccggc
    10621 cgggtgtcgg atcaccgctc gcgtcggccg gcttcagacg tgcggcgagg cgttcggcgg
    10681 tgtccagcgc ggcggagtgc aggcggctgt cgccggtcgt gccggcgaag tgcagcaggg
    10741 tcaggccgat tccggggaga ccgcccgcga gatcggtgcc gtggccgtcc gggggatcct
    10801 ggagcagacg gtccaggagg cgctgcgcct gtggggcgtg gcccaggcgg tctagggcgt
    10861 aggccacgcc gtgggaaccg atgaacagtc cgggccggca cggctcgcgg gggacggcgt
    10921 ccaggagcca ctggacgtgg tccggatcga cctcggcgcc ggtggagtgc agggcccaca
    10981 ggactcctgc cgcgccgtag gcgagcccca gcccgtcgtg ggtgaactgg gcggggtcgc
    11041 ccgggaacag gcggtcggtg cgttcggggg tcgcgctggc gtggatggcc gctgtcatgg
    11101 agtcgcgcag ggcgggccac atcgcgctgt cgccgcggag gagggcggtg agtccggcgc
    11161 gctcagggtc cccgggggga tcggggaggt gtggggaggg aagctggaac cggccggccg
    11221 cggccgaggt gagttcggct ctcttcccgg gatccagcga ggtcagctgc atcagcggca
    11281 tgtagatcca gagccggagc gcgtcgaggg cgtatgcgtc cacggcgaac ccctcgagct
    11341 ccggaggcgc cgcgaagccg gccgctccca gggcgggtct gacgaactcc gcggccagtg
    11401 aggcgagttc gaagtcgatg aacgtcaccc ggccgtcagg gccgacgatc aggttgcgtg
    11461 ggtgcaggtc cccgaagacg acgccgcgct cgtggatggc gcgcaggcct tcctcgatgc
    11521 tcgccaggac ggcttgtgcc tcctcgcggt accggatgac cgtttcctcg tccggatcgg
    11581 ggtggaccaa ggggtagcgc tgcccgaacc agcggttcag gggctccccc tgcacgtact
    11641 cctgcaccag gaagtggtgt tcccacgccg tcaggtagtc gagtgccgcg ggtaccgcgg
    11701 acagtcccgc cagccggtcg aggatgtcgc gctcccggcc gagtctgagc accgcgtcgt
    11761 cgccgcgctg gtcgaggccg gcgtgcggcc gcgcctcctt caggaccacg tggtcgccgc
    11821 cgccgacggg ccggccgaca tagatgcccc cgccgttgga gaagtgcagc gcacgttcca
    11881 ccgtgtacgg gaagtccgcc atgctcgccc ggctctgatc ggcgagggcc tgggcgagga
    11941 ccgccggcac gggggcccag tcgggcactt cgaacacggc gcgccgtacg tccgggcgga
    12001 ggcggcccga cggctcgcgg aaggcgagca cgagctcccc ggtctccgag cggcagaaat
    12061 gctcggtgaa cccgccgtag cgcaggtgga gcggtccctc gcgccagcgt aagtcgctga
    12121 ggatgtacgg cccttgctgt ccggtcagtg ccgcgccgag gtcgtgcaga catcgctcca
    12181 gtgcgtcgtc gccgaccggg tacagcgtca tgaacttgcc gctcgaaccg cgcgaggcgt
    12241 acttcgcgtt ctgcgtctgc accagtgcgg ggctgcgcag gaacttgaac gccatccggt
    12301 tctcgaagca gtacgcgctg acgacggaga ggatgtgctc ggcgttgtcc aggcatgcgg
    12361 acacatggat cttccagccc tgttcgggca ggtcgaggtc cgccggctga cggcccaccc
    12421 atacgtccct cgccctgccc acccagccgt cgggtaaggg ctcgccggcg gcggcgaact
    12481 cctcgacggt ggcccagcgg acaggcgagt cgtagaacag cttgtcggcg tatgagtacg
    12541 cctcataacg catgtccatg gcgacccccg atgtgacgag ctctcgcgac cacattcatc
    12601 gcgaatgacg ttcccggtcg cggacgcctc caccgtgtgg tggcttcgcc gctcgcggcc
    12661 tctgatgtga aggtagggga ggggaaccgt gagggacagg gcgcgcgcag tgtacggaga
    12721 gggggcgcga ggcccgcact caaaaaggaa gtgtatgtaa atgcgcccgt atacttattc
    12781 gagagctgtt tttaggattg tccctccggt attcctgcgc gacgtcgggc aacaggcgcc
    12841 acaccagcgg tcccggcttg accctgacac ggtgacaagc ctttgactgc ctggccgaag
    12901 gaggtggtcg cagatggcga tcagcacaca ggagcccgac gcggaacgag ccctccaggg
    12961 actggaggac ggtcgtgcgt ccgtgcgtct gcgggccgct ctggcgctgg gcacggcgcc
    13021 cgaaccgcgc ttcgtggaca agctcgtcca acggagtgcg gtcgagcccg agttcttcgt
    13081 ccgtgacatg ctgacgtggg cactcacccg ccacccggtg gacacgacac tgcccgcact
    13141 gctgcgcgaa gtccgcgcca agtccgcgca ggcaaggagc caggccctgc acacgctgtc
    13201 caagatcggg gacccccggg catggccggc gatcacccgg acgctgctct ccgacccgga
    13261 catcgaggtg gcgcggagcg cctggcgggc cgcggctgtc ctcgtcccgg aaggggagga
    13321 acacgccttg gccacggtgt tggtcaccca gctcggacgt ggcggacggg agacacacct
    13381 gagtctcagc agggcgctgg tcgcgctcgg ggatgtgcct ccgctgctgg ccgcgacgac
    13441 ggctcccgat cccgtcgtcc gcgcgcacgc gctcgccacg cgccggctgc tgcgcgaccc
    13501 cgacgccgga ttcgcgtgcg cgatcgagga ggccaagcgc gtggtggccc tcggcgggcc
    13561 cggccaggag ggacgacagg cgtgctgatc ggtgaggtgg cgcggcgctc cggggtgagt
    13621 gcccgcatgc tccggcacta cgagtcgctc gggttggtgc gtccttcggg gcgtaccgtc
    13681 tccggctacc gggagtactc cggggaggac atccagcgga tcttccacgt cgagagcctg
    13741 cgctcgctcg gactgtcgct gcgggagatc gggcgggcgc tcgacgatcc cggcttcacg
    13801 cccccggcgc tggtggagga cctcatcggc cggacacgcg aacgcatcgc ggcggagacc
    13861 gagttgctca cccggctgtg caggatcgac gccacggacc ccacgggctg ggaggacgtc
    13921 ctccaggtcg tcgcgctcct ccaggcactg gagtcgacga gcgccggcac acgccagcgc
    13981 gcggccctgt cctccgccca cgacgtcacg gtgccggtgg aggcactggt cgaggcggca
    14041 ctcggcgagt cggacgcgaa cgtcgccgga gcccttcggt gggcgctggc tcgcacggga
    14101 gatccgggct ccgcgctgct ggcggaaggg ctcgggtcgc cggtggccgc ggtacgggaa
    14161 cgtgccgtgc gggccctggc cgagattccc ggtgacgaga ccaccacacg cctgcgggac
    14221 gctctcgcga accatgatgt cgtggtccgc cggtacgcgg ccctggcgct cgggacacgc
    14281 ggcgtggccg acgcggtccc cacgctcgtc gacatggtgg tcgacgggag caacgacacc
    14341 gacgcggccg acgtgttgag cgtgctggcc ggtgacaccg ggacggccga ccggatcgcg
    14401 agcgcactcg tcgacctcct cacgcacggg accaccgggg cgccggcacg cgggcggctg
    14461 acccaggccc tggccggcat cccggggacg agggcgtcaa ccgccctcgc ggagctgtca
    14521 catgacccgg accgcgccgt ggcgctgacc gccgcgtacg tccttcggct gcgcggtgac
    14581 atgggaggtg acatgcggac ggttcagccg gcgagcagga gcagggcctt ctcggagggc
    14641 gatccgggtt cgacggtgta cagaccgagc gtctgatcgt catcgcccag cggggtgaac
    14701 acctcgaacc cgagggtcag gtcccctgcc agcggatggc ggtaccgttg gacgccgtac
    14761 cggggcaggt acacctcagg gccggcccac cagtcgcgga agtcccggtc gtcggcggac
    14821 agatcactca ccagctggtc gagcgtcggg tcgtgcgggt ggtggccggc gtacaggcgc
    14881 agcatgccca cgatctcgcg ggccgtttcg gcccagtcga cacacagctc acgggcggcc
    14941 tcactgagga acatgtagcg agccatgttc cactcctcgg ccggacggcc gtcgaagtcg
    15001 agatggaggg cgcgggccag acggttcgtg gccaggacgt ccagccgatg gccgagcagc
    15061 agtgccggta cgtcgccgat gttgtccagc gcccgcacca gtcccagccg ggcctgctgc
    15121 tccaccacgg cgtgggggcg ctgccgcaca ccttcgacca gcgcgaacag gtggtcacgc
    15181 tccgtgtcgt ccagttgcag cgcacgagcc acggcccgca ggacggaggg ggagacaccc
    15241 gcgccgcgcc cggcctccag ccggacgtag tagtccgcgc tcacaccggc cagctgggcg
    15301 acctcctcgc gccgcaggcc cggtgaccgg ggcaggcccg ggtgtgcggg aagacctgtc
    15361 tgctccggcg tgaggcgtgc ccggcgggtc cgaaggaact cccggagagc ggtctcaggc
    15421 gcaagctcac tcacgctctc aggctaacgg aggggtggtg ggcaccgccc gtcaatgcca
    15481 cccggccgac acggggcgcc agtcccgtac cggcggcacg gccgtggtgc gcggtcggtc
    15541 ggcggatttc acaccgtccg gcgcgattcg ctgccgacgg ctgccggccg ggcgaacacc
    15601 ggcgccgcac acccggcggc gccgcccgcg cacgagccgc acggcgggca ccccgttcac
    15661 ccgccgtgca aggggagcgg agtgagtcat cccgtggcgc cgacccggcc ggccacgcgt
    15721 cgggtgtggg tcacattccc gaccggcggg cccggagctt gccgaagagc cgctgggcct
    15781 gcgcccggcg gcgtggatcg gccgcggtac ggcgtgcctg ttcgatggtg cgctgcccct
    15841 gcgggctcct cgcgaactcc ttgagtcgtt gcagaactcc cggcatgtca ctcctctcgt
    15901 caggggtgcc ctctcgtggg ccccgcagcg ttcgcctacc cgttgaccga cggtccagcc
    15961 tcttccggcc gaaggtgagg cgtcgcggcg ccgtgccgct tgcagtcctt ccggcgcgca
    16021 cccgacagcg aggcgcgctg cctggaggaa cgcagccggc gcgggggaga gcactgaaat
    16081 ggttgaaggg ccgcgcggta cgcggacgcg gcccgactgc cccggtgcag ggcggcagcc
    16141 ggacacaggg tgcaagcgtc cccctgtccg aaggcgagcc aagcgtgttg cttccggctc
    16201 cgccccctga ttccttcgac acctgaacgc atgacgggtg ttcgccccca cgccttcgcg
    16261 tacatgtaca ccttctgtct ggagcaaggg agtcaagtcg gtgcacaact atatgaattg
    16321 ggttgcgcgg tgcgctggaa tcgtcatgtc tttgacgctt ccgttcgccc tcgcggagcc
    16381 ggcatcggcg cggtccgaaa gccctgagcc ggcccccgcc tgcgtcgcca tgtacgaaag
    16441 ctggcgctac acccaggccg ccaacgactg cgcggacacc gtggcgctga aggtcgtcta
    16501 ccaggacggt gccaccggcc cgtgtcacac gctgccgccg ggtgcgatca gcacggtcgg
    16561 cgaggggtac ctcggcctgc acggccatgc ggaccacctc gccgtctgcg ccctcgactg
    16621 accggcgacg ggccggccgg ctgtcaccgc gtcgacttgg cggcgccgct gcgcgcatcg
    16681 ccgccccgtg ccctgagggg cgcgccggcc tcggtgagga cgcggtgcac gaagccgtac
    16741 gaccgcccgt gcgcctcggc aatcgcgcgg atcgaccgtc cctcgccgta ctcctcggtg
    16801 aaggtcctgg ccaggtcctt tcgggcgctg cccgttatcc acttgccctt gtgcatggtg
    16861 atctcctctc gattcgtcga gacgtgatca ccggttgccc atctcgccgc tcctcatgcg
    16921 gccgaggtgc gcgcgggcgc ccgagcggct gcctgcgggc cgcgggcccg gacggtcggc
    16981 cgccgtcgga tccgggggat aacccccggt gcccgtgggg gaatgcctcg gggcagacgg
    17041 tggctggcag gcttcttcgg gctccgggcc cgacgaaaga cttgcgggca tgacgacttc
    17101 ccctgatgtc tccgtgatgc ccgtgtccgc ctcagccgcc gagcaacgcg gcttggccgg
    17161 taacggcagt gacttcgccc ggctctccca gcggatagcc gcggccggcc tgatgcggcg
    17221 gcgccccggt tactacacgg cacgcatcgg cctggtggtg gcgctgtacg cggcgggctg
    17281 gggagccttt ttcctcctgg gcgacagctg ggggcagttg gccgtctcgg ccttcctggc
    17341 gttcgtgttc gggcaggtcg ccctgctcgc acacgacctg gcgcaccggc agatcttcgg
    17401 gcggcgccga cccagcgaga tcatgggcag gctgttcggc aatctcggtg tgggcatgag
    17461 ttacggctgg tggatgaaca agcacacacg ccaccacgcc aatcccaatc acgaggacct
    17521 ggacccggac gtcgccccgg acattctggt gtggtccacg gatcaggcac gtgccagccg
    17581 tggtgtggca cgggtgatcg gcggccacca ggccctgctg ttcttcccgt tgctgaccct
    17641 cgagggcttc aacctgcacg tgtcgagcct gcgggccctg cgcgcgccgt acatgaagaa
    17701 gcgcgcgctg gagggagccc tgctcctcct gcacatcgcg ggtctgctgt cggctctgtt
    17761 cctgatcctc tcgccgggca aggcgctcgc gttcctggcg ttgaaccagt gcctgttcgg
    17821 tgtgtacctc ggctgcacct tcgccccgaa ccacaagggc atgcccacct tcaccggtga
    17881 cgagcggccc gacttcctac ggcgccaggt cctcacctcc cggaacgtgc ggggcggccg
    17941 gctgaccgac gtgatgctcg gcggcctcaa ctaccagatc gagcaccacc tgttcccgag
    18001 catgcccacc cctcacctgc ggcgcgcccg gaccgtcgtg cggcagtact gcgcggagat
    18061 cggggtggcc tatcacgaga ccggattgat ccgctcctac cgtgaggccc tggcccatct
    18121 gcaccgggtg ggtgagccga tcaggcggca gcgcagggca cggtgacccg tcggggaccg
    18181 gcggagacat gccgcagccc gggcacgtac gactgggtcc gggctgcgga atcggcggtt
    18241 tcgtgtggcg gtggtgtcag gcggtgaggg tctcccggag agcttcgagg ccgtcacggt
    18301 agatcccggc gaagaggtcc tccgcttcgg cgtcgctcac cccgtcgggc gtgaagcggc
    18361 cggaccactg cacctcggcg acgtcgtccc ggccggcgac cgggtggacg cggagcgtgg
    18421 agaggtatcc ggtgacggga aagggcgcgt cgacgatggc gtagctgtac gagcgctccg
    18481 cctcgctgta ggcgatgagg cgctcggtga tcacgtcacc gtcggggttg gtgaggcggc
    18541 ggacccggcc gccttcgagc ggggtgctct cgcggatgaa cgggagccag tcggggaggg
    18601 cgtcgaatcc gccgatgagg tcccagacct gctgggggga ggcgggcagg acgcggctga
    18661 cggatgtgga ggccatggtc gtgctcctgg gggtcgtgcg gtgtgtccgg gtgggggagg
    18721 agtgcggggg tcaggcgccg gggggaaggg gagcggccgg gctgaccagg ccggcggcgc
    18781 gcaggtcggc ccagaacgcg gcggggatgt gctcgtcgag ggcggcggtg tcctcggcgg
    18841 tacggctcgg gcgggtggcg ccggggatga cggcgaccgc cgccgggtgt gccagcgaga
    18901 actgcagggc ggcggccttg atcccgactc cgtgctgcgc ggcgaggtcc ttcagccgcc
    18961 cgacgcgctc gatgatctcg gccggggcct gctggtactc gaagtgggtg ccgccggcca
    19021 ggacgccgga gctgtagggg ccgccgacga ccatgccgac gccctgctcc tgcgccaggg
    19081 gaagcaggcg ctggagggcg tggccgtggt cgaggagggt gtagcggccg gccaggagga
    19141 agccgtcggg ccggggctcg tcgagggcga gggtcagctc gatgggctcg gtgcggttga
    19201 cacccaggcc ccaggccttg atgacgccct cgtcgcgcag ccgggacagg acgcggaagg
    19261 cgccggtacg ggcctcctcg aacttctgga gccacaggtc cccgaggaag tcctgggcga
    19321 tgtcgtggac ccacacgatg tcgagccggt cggtgcgcag gcgcttcagg ctgtcctcga
    19381 tggaccgctc ggtggcctcc gccgtccact cgtggacgat cttgttgggg ttgccgtgtt
    19441 cgaagaggcc gcccttctcg ccgaggtcgc gggcggaggt ctcgtgctcg tcgaggatga
    19501 cccggccgac cttggtggac aggacgtagg agtcgcgggg cttgccggcg agtacctcgc
    19561 cgagtcgctg ctcggccagg ccggcgccgt agaagggggc gctgtcgtag aagcggatgc
    19621 cgtggtccca ggcggcttcc acggtggcgc gggcctcgtc gtcggggatc gcgcggaaca
    19681 tgttgccgag cggggcggtg ccgaagccga ggcggccggg gatgaggtcg gtgagtgaca
    19741 tgactgtgcc tctgcgtggt acgcggcgat acccgggccc cgcggctccg tcggcggagc
    19801 gagcgcgggg aggcgggtag ccacggggtg gtccgagcgc ccgcattcat tgcaggcgcg
    19861 ccttacttgc gatgacaata cttgcacacg cgggctattg caaggtgtgt cggatgctcg
    19921 aggtggtggc ctcggcggcc gtgcggcgga gtgcggtgcg gtggagtgtg gcgcgttgaa
    19981 gtgcagcgtg ttcgcaaatg tcgatcgggg gcgacgccgg agtccggatc cgcacgctcg
    20041 ggtgatcgct ctgctcacgg ggtcaccccg acagcgtgtg gaccagttcc gccgtggtga
    20101 cgatggcgtg cgcgtaggtg gggccgttca gctcgtgtgc ggcgcgcagc atgtcggcac
    20161 tgaaggccgc ggtcgcatcg gtgacgaggg tgacgtggta gccgagttcc atcgcgaagc
    20221 ggcccgtgga ctcgacgcag gtgttggcga gcagcccgat caggatcacg tgggtgacgc
    20281 cgtgttgctt gagccggcag tccaggtcgg tgttggcgaa gccgctctgg gcccagtgct
    20341 ccgcgatccg caggtccccc ggtcgcggct ggaagtccgg gtggaactcg cctccccagc
    20401 tgtcgcgggc gaagagccgc aggcgtcgcg ccttccgctg ggtgggattc gggtggtccc
    20461 agccgacgta gtcgccctcc tcgtaacgcc ggtgcggaac gaacgccacc agcaggccgg
    20521 ccgtgcgggc cgcgtcgacg accgcgcgca ggttgcgcaa cagacccact tcgtcggcca
    20581 ccggggccag gcgcgaccac agcttgcccc cttcggagag gaagtcgttg taggggtcca
    20641 ccagcaggac cgctgtgcgg ccggtgtcgt aacggtccgt catgacggcc gccttccgga
    20701 gagtgtgcag gtgatccact atcggctcgc gcacgcggcc cggccctgcg gctcgccgac
    20761 cggaccccgc ctgcccgcgc gtaagcacta catctgaagt cgtttctcgt gggcattggt
    20821 ggtatatcga cgacgagaac ggacgacttc tcaccgggga cggggaacgg gacaggagcc
    20881 cctgcgccca ccgtcaagac tgcggatgag gtgtgcgatg cgcaagatca tgacaggaac
    20941 ggccacgacc ctgctcgcgg cagccgtgct ctgcaccgga tcccccgccc aggcgctcga
    21001 cggcacgcgg gccgccccgg aagcgagcgg gttctgcggt acggacccgg cctccggcct
    21061 cgccgtctgg ggcgaccgcg ccgacgcctg cgccgccgcc ctggcagtgg cgagcgccta
    21121 caccaaggcc gcagccggta cggccaaggg gcccggcacg gtccgcgcgg gcggagccac
    21181 gtggaagtgc caggagcggc agggagaccc caacccctac caggaatgcg tcgacgcgag
    21241 cgacagcggc cgcagggtcg tcctctcgtc ctgacccgcc ccccacctga cctggcgctg
    21301 ggcgccgcgc tggactgcac taaggtgctt gctgcgccga gtccaagggg gatcatgacg
    21361 actgtcgccg agtcgccgca ggtcagcagt acgcctttgc ggatcgcggc tttccggagg
    21421 ttcgtgtcgg cgaacctcat ctcggcggcg gggtcggcga tggcccccct cgcgctggcc
    21481 tactccgtca tcgagcaggg cgggggagcc ggctccctcg gtgtcgtcct cgccacgaac
    21541 accgttccca cgatcgtgtt cctgctcgtg ggcggcgtcc tcgcggaccg cctgtcccgg
    21601 agccggatcc tcttcctcgg caacctgctg gcggcgggcg cgcagggcgc cctggccgtc
    21661 accgtggcca ccgggcacgc gacgacggcg tcgatcgcgg cttgtgggtt cgtctcggga
    21721 acggcggcgt cgttcatcgt cccggccacg cagggcgccg tcgggcagat cgttcccgag
    21781 gagcatctgc agcaggccaa cgcgctgctc aggctcccga gcaacgcggt caaggtactg
    21841 gggccggtcg tcggcggatt ggtcgtcgcc gcgagtggcg ccgcatgggc gctggcgtgg
    21901 gacgcgttca cgttcgccgt cgccgccgtc ctgcttctcg gtctgcgcct ggaggcgccg
    21961 cccggcgcgg ccgccggagt gctggccgac ctgcggacgg ggtggacggg tttccggtcc
    22021 cgcacctggc tgtggaccta cacggccgcc ggtacggtcc tcgtcgcggc gtggctggcc
    22081 ggcttccagc ttctcggccc cctcgtcgcc gcccagcggt acgccggacc gcgcgactgg
    22141 ggcctgatcc aggcggcctt ctcctgcgga ctgctggcgg gcaccgtcgt ctgcctgcgc
    22201 tggaagccct accgcctgct ggcggtcgcg atcgccgcga gcggtgccct cgcgctcccg
    22261 ttggcggcca tggccgtcgg cctgccgttg ccgctggtgc tggtggccgc cctgctggcg
    22321 ggtatcggac tcgacgtcgc catcgtcgcc tggaccaccg cgttccaaca gcacgtgcca
    22381 caggaggagc aaggtcgcat gagcgccttc aacggtgtcg gggaacgcct cgccatcccc
    22441 ctcggctacc tcgtcaccgc cctcgcggcc cagtcgtcca gcagccaggt ggtgctgctg
    22501 gcctgcgccg gcgtgatcgc cgccgccgcc gtactcaacc tgtgtgtccg ggacgtgta
//
