LOCUS       NZ_LIWA01000005        22841 bp    DNA     linear   CON 28-MAR-2024
DEFINITION  Streptomyces sp. CB01883 scaffold5, whole genome shotgun sequence.
ACCESSION   NZ_LIWA01000005
VERSION     NZ_LIWA01000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CB01883
  ORGANISM  Streptomyces sp. CB01883
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 770318)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 770318)
  AUTHORS   Yan,X., Ge,H., Hindra,F., Yang,D., Huang,T., Crnovcic,I. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-AUG-2015) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2014
            Assembly Method                   :: CLC Genomics Workbench v. 7.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905855.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:34:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,089
            CDSs (total)                      :: 8,009
            Genes (coding)                    :: 7,788
            CDSs (with protein)               :: 7,788
            Genes (RNA)                       :: 80
            rRNAs                             :: 3, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 221
            CDSs (without protein)            :: 221
            Pseudo Genes (ambiguous residues) :: 0 of 221
            Pseudo Genes (frameshifted)       :: 85 of 221
            Pseudo Genes (incomplete)         :: 169 of 221
            Pseudo Genes (internal stop)      :: 25 of 221
            Pseudo Genes (multiple problems)  :: 50 of 221
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:33:31
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 275675
            Orig. end                         :: 298516
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LIWA01000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22841
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22841
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22841
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12841](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12841)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    177..191
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
     misc_feature    232..247
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.56"
                     /tool="antismash"
     CDS             318..380
                     /gene="allorf_275993_276055"
                     /locus_tag="allorf_275993_276055"
                     /protein_id="allorf_275993_276055"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MIAGGGAGGARRCADPGKFT"
     CDS_motif       318..344
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MIAGGGAGG"
                     /locus_tag="allorf_275993_276055_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       345..380
                     /prepeptide="core"
                     /locus_tag="allorf_275993_276055_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.50"
                     /molecular_weight="1203.4"
                     /monoisotopic_mass="1202.6"
                     /core_sequence="ARRCADPGKFT"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MIAGGGAGG"
                     /leader_location="[317:344](+)"
     gene            413..934
                     /locus_tag="AMK32_RS23915"
                     /old_locus_tag="AMK32_23510"
     CDS             413..934
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019498.4"
                     /locus_tag="AMK32_RS23915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_23510"
                     /product="cupin domain-containing protein"
                     /protein_id="WP_123439146.1"
                     /transl_table=11
                     /translation="MTDDPSRMPAAPLLRRPGDGELIDVAGVAHFFRLTGEHTGGRFAF
                     EEFALAPGTVGARPHVHEGHDEYFYVLEGELTLHTGDGEVTAGPGHLLAATRGTPHGFR
                     NAGPVVARALCLYTPAGYENYFREVHAAVSAGAEATDELLAEFRGRHRTTSHPLPSARS
                     ESEPVGPDLP"
     gene            931..1446
                     /locus_tag="AMK32_RS23920"
                     /old_locus_tag="AMK32_23515"
     CDS             931..1446
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005321979.1"
                     /locus_tag="AMK32_RS23920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_23515"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_073895855.1"
                     /transl_table=11
                     /translation="MTQPPPRLRLLHPGHAPALLAFERENRAYFARSVPDRGDDFFTRF
                     DERLRALLAEQEAGVCHFHVLLGGEGEVLGRVNLVDVADGGADLGYRIAERAAGRGLAT
                     WAVRALCHRAADRYALTHLRAAARLDNPASRAVLVKTGFTVVGETRLSGHPGLTYRRPL
                     GEVPAPPP"
     gene            1528..2271
                     /locus_tag="AMK32_RS23925"
                     /old_locus_tag="AMK32_23520"
     CDS             1528..2271
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014670881.1"
                     /locus_tag="AMK32_RS23925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_23520"
                     /product="beta-phosphoglucomutase family hydrolase"
                     /protein_id="WP_073895857.1"
                     /sec_met_domain="HAD_2 (E-value: 1.4e-15, bitscore: 53.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLRLPPHIRACLFDLDGVLTQTAKVHAAAWKEMFDGYLRERAARE
                     GAPFVPFDAVGDYDEYVDGRPREDGVRTFLAARGVHLPEGSPDDPPESETVNGLGTRKN
                     ALVLRRIREAGVEPYEGSVRFVHAVREAGLRCAVVSSSANCRDVLAAAGIDDLFDERID
                     GVVARDRRLRGKPAPDTYLEAARGLDTEPDAAAVFEDALAGVEAGRAGRFGVVVGVDRV
                     GQAEQLRAHGADVVVRDLAELLESR"
     gene            2268..4667
                     /locus_tag="AMK32_RS23930"
                     /old_locus_tag="AMK32_23525"
     CDS             2268..4667
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009720867.1"
                     /locus_tag="AMK32_RS23930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_23525"
                     /product="glycoside hydrolase family 65 protein"
                     /protein_id="WP_073895859.1"
                     /transl_table=11
                     /translation="MITHPSFTVEPWCLRETELNLEVLAQSESVFALSNGHIGWRGNLD
                     EGEPHGLPGAYLNGVHERHPLPYAEAGYGYPESGQTMINVTDGKIIRLLVDDHPCDLRY
                     GQLLEHERVLDFRSGVLSRTARWTSPGGRTVRITSRRLVSFAQRAVAAVVYEVEPVDGP
                     ASVAVQSELVANEQLPTITGDPRVAAATRSPLVGEEYFAQDTRLRLVHRTEASALRVGA
                     AADHLVEGPGSTRWTAQCEPDVSRLTVTADLEPGQPLRLVKFVAYGWSGERSLPAVHDQ
                     VDGAVAAAVSTGWDGLVAAQRAYLDRFWAGADVEVEGDAQIQQAVRFALFHVLQAAARG
                     ENRAIPAKGLTGTGYDGHSFWDTESYVLPLLTFTAPEAVAPALRWRHGTLPAARERARQ
                     LGLAGAVFPWRTIEGAECSAYWPAGTAAFHINADIANAAVRYVMVSGDEEFDRGEGLDL
                     LVDTARLWRSLGHHDAAGVFHIDGVTGPDEYSAIARDNLYTNLMARQNLVAAADAVTRH
                     PDRAAELGVDDEEAAVWRDAAARMAMPYNDTLGVHEQSAGYTHFQRWDFEATPPENYPL
                     LLHYPYFDLYRKQVVKQADVVLAMLEFPNAFTEEQKARNFAYYEALTVRDSSLSACCQA
                     VLAAETGHLRLAYAYLGEAALMDLDDLEHNTRDGLHIASLAGTWIALVSGFGGMRRHIG
                     EDGRPDLLGFAPRLPEALSRVAFTVLMRGRRLKVDIGPTHVRYRLVEGEPLEVLHHGEP
                     LTVTAGAPVERPVPPATARPEPQQPRGRRPAGLATEEEQLRPEAQE"
     gene            4751..5179
                     /locus_tag="AMK32_RS23935"
                     /old_locus_tag="AMK32_23530"
     CDS             4751..5179
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010033637.1"
                     /locus_tag="AMK32_RS23935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_23530"
                     /product="hypothetical protein"
                     /protein_id="WP_073895861.1"
                     /transl_table=11
                     /translation="MTESNDDSSRKSAAVRESASKARRTADKATAPAGRAAKKAATTTD
                     GAVSAAKAGTERAAGATSAAARTAAQGVESGRQALITASGQVAATAKTAWTVIAHRKMI
                     AAGVGAGLTAWTAASYALGRRSERQTHGPLTRLTSGRF"
     gene            complement(5460..6149)
                     /gene="snpA"
                     /locus_tag="AMK32_RS23940"
                     /old_locus_tag="AMK32_23535"
     CDS             complement(5460..6149)
                     /EC_number="3.4.24.77"
                     /codon_start=1
                     /gene="snpA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019983653.1"
                     /locus_tag="AMK32_RS23940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_23535"
                     /product="snapalysin"
                     /protein_id="WP_073895863.1"
                     /transl_table=11
                     /translation="MASFPMPDRPKNSRRLLALALGLGLASAALGTATPASARSTAEAP
                     ARTSAAGYVGSAESSGDKAFFDAVLNSVAKRQAAQPSLKVVTVYYNASQAPSFRSQISS
                     AASIWNSSVSNVKLQATSGGADFAYYEGNDSRGSYASTDGHGSGYIFLDYAQNRQYDSI
                     RVAAHETGHVLGLPDHYSGPCSELMSGGGPGTSCTNRYPNSTERARVNQLWVNGLAKAV
                     ARLSKTG"
     misc_feature    6319..6334
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.3"
                     /tool="antismash"
     gene            6363..7400
                     /locus_tag="AMK32_RS23945"
                     /old_locus_tag="AMK32_23540"
     CDS             6363..7400
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010985831.1"
                     /locus_tag="AMK32_RS23945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_23540"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_073895865.1"
                     /transl_table=11
                     /translation="MELEVRHLRVLCAIADTGSLHKAARQLGLAQPSLSTQLRRIEHAL
                     GAPLFVRARTGCRPTPLGLAVLSRARPLVAEFAAIVTETRAAAARAAGGFQLRIGATAS
                     RAIPGWLRLLRARVPRIEPTLQMNVSANFLLGMVAAGRLDIAFVHEVEGSPLRIPPGLS
                     LRVLVEREPQFVTLAADHPAAARRQVPLSDLAGDRWMVDSTVDGEWDALCRALRAAGLE
                     SEMLHGDYLTAYSLAATGEVVTVSQPTAHPRPDLAIRPLEGDPIGVRLLLAARTEAELD
                     DVYPELAESYWTVARDAPAYREWLERARVPLVPLDRAAEPPLGRRRPGCPAQAPARPAA
                     PSTHR"
     misc_feature    6693..6695
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7530..8109
                     /locus_tag="AMK32_RS23950"
                     /old_locus_tag="AMK32_23545"
                     /pseudo=""
     CDS             7530..8109
                     /NRPS_PKS="Domain: PKS_KR (8-152). E-value: 2.1e-08. Score:
                     26.2. Matches aSDomain:
                     nrpspksdomains_AMK32_RS23950_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019526410.1"
                     /locus_tag="AMK32_RS23950"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_23545"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MDDDRPLALVTGASSGIGYELAGRFAENGFDLLINAEDDRLDHAA
                     QRLRESGAGVRAVRADLRAPEGVDKLVAATTGLRIDVAVLNAGVGQGGAFADTDLADDL
                     AIVDLNVASTVRLAKPLLRDMLTRGEGRMAFTSSIAATMPGSFQPAYDAIMQDEGPGPG
                     EQGPAGQCEGRPAPLHGRTGNGRGHRRTRL"
     CDS_motif       7554..7616
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMK32_RS23950_0001"
                     /evalue="3.00E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="AMK32_RS23950"
                     /protein_end="29"
                     /protein_start="8"
                     /score="10.3"
                     /tool="antismash"
                     /translation="LVTGASSGIGYELAGRFAENG"
     aSDomain        7554..7985
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMK32_RS23950_PKS_KR.1"
                     /evalue="2.10E-08"
                     /label="AMK32_RS23950_PKS_KR.1"
                     /locus_tag="AMK32_RS23950"
                     /protein_end="152"
                     /protein_start="8"
                     /score="26.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="LVTGASSGIGYELAGRFAENGFDLLINAEDDRLDHAAQRLRESGA
                     GVRAVRADLRAPEGVDKLVAATTGLRIDVAVLNAGVGQGGAFADTDLADDLAIVDLNVA
                     STVRLAKPLLRDMLTRGEGRMAFTSSIAATMPGSFQPAYD"
     gene            8215..9963
                     /locus_tag="AMK32_RS23955"
                     /old_locus_tag="AMK32_23550"
     CDS             8215..9963
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019068168.1"
                     /locus_tag="AMK32_RS23955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_23550"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_073896741.1"
                     /sec_met_domain="Pkinase (E-value: 5.5e-48, bitscore:
                     159.1, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDAGSDTSGRRVVDGRFELEKRLGGGGMGMVWLARDLMLHRHVA
                     VKEVRPADPDLAEYDPEAARQLRERVLREARALARVDHPNVVTIHHIVDGGAGGFPWIV
                     MELVTGGSLADRLARGPMDPREAALLGREVLAALSAAHAAGIQHRDVKPANVLLRPDGR
                     PVLTDFGIAAIRESTALTATGSVIGTPDYMAPERVSGHDGGPASDLWSLGMMLYTAVEG
                     RHPLRRGSTLATLAAVISEDIPPPVHAGALTDVLARVLVRDPAARPGAGELERMLEAAA
                     RDAGTPPTSYQLQPPPVEPPHPAPTTVTPGAPGPGHTTAADGFGPAPVMLPGPYGGTGQ
                     TVAPGPEDARPGSTTMPVRRGRGRRWTLVTVPVVGVALAGTLMWTLRPDGGTHDSSSGS
                     GSSHSADATTGAATPTGPARVSASPAGKEQTTGKSLLTPDGIRTAVEAIKKATGRDRFG
                     SLTVYPEYVSADVMVKGSDTKYDSYTYRPGQEVEEGIIHGKLTLGDAAITLDGFDWDAV
                     PALIREAEKKLNVDHPKTRYLVLELADDAFGTPDGMAVYLSDDYGTGYLQADRKGKVVR
                     VMPADG"
     gene            complement(10001..12841)
                     /locus_tag="AMK32_RS23960"
                     /old_locus_tag="AMK32_23555"
     CDS             complement(10001..12841)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="AMK32_RS23960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_23555"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_073895867.1"
                     /sec_met_domain="DUF4135 (E-value: 1.8e-72, bitscore:
                     240.1, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 5.7e-38, bitscore:
                     126.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNASAADGGERAEWFDGPVRGIARPWREDLARRLAAVTALHGEER
                     DVLLEAGHTALLNSLHAKLTRLFLVELHALRMAQGVPDAGRPGAPDTATWNAFVEQAGA
                     EGYLDKLAGRYPSLGRRVAVVARMSVAATAALAERLAADRDLLAPLLGAPAGRLGAVTF
                     GAGDSHGGGLTVSRLDLTGGTVMYKPRPSEVDVALGAMLEELFADFPEAPPRDERIRVP
                     RTLPREGYGWAEFVEHRYCADDTELAAFYRNMGHWLAVLRFTGGTDMHAENMIAAGPVP
                     VIVDAETLFDAPAPFPPSGRGDAVDLAAAIRRTVLRTGLLPVRGTGFALGGVDISGVGA
                     LPGQQPLIPNPVIAEGGAAAARFEVDLVAMPTAGNHPSPTPVLSTYWDRILAGFQEMTA
                     HLRRDEVDPLRLLHRFEGARVRRIRRPTQAYVDIGRMLWHPASLHDEDTAVARARDILR
                     RNAEVLPGAPTDTGTIDGEIADLLAGDVPLFAFTVDGTVVRNTVEDWRTADFALEESVI
                     QDALVGAYLNERSLPARVRVAAERPHARDREPRRRRLAAAMVRRLCDGAVRGADGTVTW
                     ISPVFTPAGWSIRVLPADLYTGQGGVALTLAEYVHEVRAGRADEVPGVEETFEGALRVL
                     IGTEDRTPTPSAGAFSGAASQVWTWLALHRVLDEPWPLARAAQRAVLLEGRLVDDDVEV
                     DLLNGAAGGIVPLIGLAEATGQDRWLSVAAHIGRRLIRLAAVDSGGARWTTRLNPEGIG
                     GFAHGATGIGWALARLALSGAGTPAERRAWRHIAERAFDFQESLWQPDAGNWLDIRDGA
                     EEDFFTSWCHGSAGVGIGMLDLHRRTGEPAHLDMARRAARACAAEGFGWSHTLCHGDLG
                     LWRFLTSMGGEGADGLGTLDDLDGEILTGLEQRGPVGGLAREAFSPSLMSGLSGVVHTL
                     LCMHRSASLPDPLLLD"
     gene            complement(12910..13110)
                     /locus_tag="AMK32_RS23965"
                     /old_locus_tag="AMK32_23560"
     CDS             complement(12910..13110)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017240677.1"
                     /locus_tag="AMK32_RS23965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_23560"
                     /product="DUF6229 family protein"
                     /protein_id="WP_198960451.1"
                     /transl_table=11
                     /translation="MSQNSVRTAAVLEAWLSGAETAYGELNPAGPLYVGGTAAEAALTD
                     PSDSLYGFCSSPSGSRGSWCC"
     CDS_motif       complement(13039..13110)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSQNSVRTAAVLEAWLSGAETAYG"
                     /locus_tag="AMK32_RS23965_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(12910..13038)
                     /prepeptide="core"
                     /locus_tag="AMK32_RS23965_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.60"
                     /molecular_weight="4033.4"
                     /monoisotopic_mass="4030.8"
                     /core_sequence="ELNPAGPLYVGGTAAEAALTDPSDSLYGFCSSPSGSRGSWCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSQNSVRTAAVLEAWLSGAETAYG"
                     /leader_location="[13038:13110](-)"
                     /alternative_weights="4051.4"
                     /alternative_weights="4069.4"
                     /alternative_weights="4087.4"
                     /alternative_weights="4105.4"
                     /alternative_weights="4123.5"
                     /alternative_weights="4141.5"
     misc_feature    complement(13096..13110)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.54"
                     /tool="antismash"
     CDS             complement(13191..13388)
                     /gene="allorf_288866_289063"
                     /locus_tag="allorf_288866_289063"
                     /protein_id="allorf_288866_289063"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MNAEEAGPAVGGHAVFLAGGERARGDLGLIVGAAGRPRESDWCHR
                     TPLPRPSSPGSPVDHRTTVA"
     CDS_motif       complement(13290..13388)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MNAEEAGPAVGGHAVFLAGGERARGDLGLIVGA"
                     /locus_tag="allorf_288866_289063_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13191..13289)
                     /prepeptide="core"
                     /locus_tag="allorf_288866_289063_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.30"
                     /molecular_weight="3397.7"
                     /monoisotopic_mass="3395.7"
                     /core_sequence="AGRPRESDWCHRTPLPRPSSPGSPVDHRTTVA"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNAEEAGPAVGGHAVFLAGGERARGDLGLIVGA"
                     /leader_location="[13289:13388](-)"
                     /alternative_weights="3415.7"
                     /alternative_weights="3433.8"
                     /alternative_weights="3451.8"
                     /alternative_weights="3469.8"
                     /alternative_weights="3487.8"
                     /alternative_weights="3505.8"
     misc_feature    complement(13381..13392)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     gene            13437..13994
                     /locus_tag="AMK32_RS23970"
                     /old_locus_tag="AMK32_23565"
     CDS             13437..13994
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007497239.1"
                     /locus_tag="AMK32_RS23970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_23565"
                     /product="hypothetical protein"
                     /protein_id="WP_317633587.1"
                     /transl_table=11
                     /translation="MAAGALTGCGNGGGGTGSTASATPTAPDTASFSGAPPSALASSAS
                     SAIASARESASAAASSASARAEEFEASVSAEFERRTQAAQNALKGVKGSGNAVSDVGMT
                     GIPKAQTGGVLAVLVTITNKTSQKASYAVQIDFEDADHHVVETRYTGAENLEPGKKEQP
                     IVFSHQQSEQNLTPRLAKAQRY"
     gene            complement(14037..15242)
                     /locus_tag="AMK32_RS23975"
                     /old_locus_tag="AMK32_23570"
     CDS             complement(14037..15242)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020127216.1"
                     /locus_tag="AMK32_RS23975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_23570"
                     /product="spore photoproduct lyase family protein"
                     /protein_id="WP_073895871.1"
                     /transl_table=11
                     /translation="MPYPTAGPDGDSDALFGLDALAGTATPGGGGTGPARLPEGRAPFR
                     DSPAARRLLPVRHVYAEPAAAASPRGREILARFPAANVVEVDSHWRIPGLHGNEGNVER
                     WVRVKGETLVLGERKSLTTRPNGRSADWIAPGASNGCAMACAYCYVPRRKGYANPVTVF
                     TNIDRIIAHLGRHIARQGPKREPNQCDDTAWVYDVGENGDCSVDALICDNTADLVHAFR
                     QWPTAKASFATKYVNPDLLALDPRGRTRVRFSVMPAEDSRLLDVRTSPVGERIAAAADF
                     LDAGYEVHFNLSPVVLRPGWKEAWAEVLRQLDDVLPDRVKQQAAAEVIMLTHNRELHEV
                     NLGWHPRAEEVLWQPGLQEAKRSENGAVNVRYDHRVKAEAVQAVRTLVAAHAPWLRIRY
                     AF"
     gene            complement(15340..16098)
                     /locus_tag="AMK32_RS23980"
                     /old_locus_tag="AMK32_23575"
     CDS             complement(15340..16098)
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971499.1"
                     /locus_tag="AMK32_RS23980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_23575"
                     /product="TetR/AcrR family transcriptional regulator
                     C-terminal domain-containing protein"
                     /protein_id="WP_073895873.1"
                     /transl_table=11
                     /translation="MAKQVVPEAARRRRRPTQQGTVLSEALIVRTALRVLREHGSAGLT
                     ARRLGTALGADPSTLYRYFGGMDDLTRAIGEELMGRALDSWTATGEWRADLRALGLAIH
                     SAYLAHPHAAALTASRVSGRPREIAVDETILGILRSAGFPDPAAVRLYHAFIDLSLAFV
                     ALDAGALALTEEARAADEDMWTSTYARLPAESYPHIAATAPLLAARMPHSAYATVLDTL
                     LDGAAAQLAPARSGTARRRSARPDGPADGR"
     misc_feature    complement(16088..16101)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.34"
                     /tool="antismash"
     gene            16228..17451
                     /locus_tag="AMK32_RS23985"
                     /old_locus_tag="AMK32_23580"
     CDS             16228..17451
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031800.1"
                     /locus_tag="AMK32_RS23985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_23580"
                     /product="saccharopine dehydrogenase C-terminal
                     domain-containing protein"
                     /protein_id="WP_073895875.1"
                     /transl_table=11
                     /translation="MRVLLVGAGGVGTAVTRIAARRDFLAHMVVADYDLSRAEAAVTAL
                     KERGDRFSARRLDASDEDGVRRLLAEERCDVLLNATDPRFVMPLFRAALAAGAHYVDMA
                     MSLSAPHAERPYEECGVKLGDDQFALAGRWAESGRLALVGMGVEPGLSDVFARYAADEL
                     FDEIEEIGVRDGANLTVEGYDFAPSFSIWTTIEECLNPPVVYEKDRGWFTTAPFSEPEV
                     FDFPEGIGPVECVNVEHEEVLLIPRWVDARRVTFKYGLGDDFIAKLKTLHELGLDSTAK
                     VGVPGEDGAVRVSPRDVVAACLPDPATLGDRMTGKTCAGTWVKGTKDGAPREVYLYHVV
                     DNRWSMDEYGSQAVVWQTAVNPVVALELLATGAWSGKGVLGPEALPPRPFLDLLTEYGT
                     PWGLREQG"
     CDS             17519..17698
                     /gene="allorf_293194_293373"
                     /locus_tag="allorf_293194_293373"
                     /protein_id="allorf_293194_293373"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MCPGRAAAAVAVQRSRSAAAEVSWAAGRHRHEAGDGIRTRVSRCA
                     GEVAAACAPERSPP"
     CDS_motif       17519..17671
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MCPGRAAAAVAVQRSRSAAAEVSWAAGRHRHEAGDGIRTRVSRCAGEVAAA"
                     /locus_tag="allorf_293194_293373_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       17672..17698
                     /prepeptide="core"
                     /locus_tag="allorf_293194_293373_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.20"
                     /molecular_weight="837.9"
                     /monoisotopic_mass="837.4"
                     /core_sequence="CAPERSPP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MCPGRAAAAVAVQRSRSAAAEVSWAAGRHRHEAGDGIRTRV
                     SRCAGEVAAA"
                     /leader_location="[17518:17671](+)"
     gene            complement(17748..18239)
                     /locus_tag="AMK32_RS23990"
                     /old_locus_tag="AMK32_23585"
     CDS             complement(17748..18239)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017945613.1"
                     /locus_tag="AMK32_RS23990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_23585"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_073895876.1"
                     /transl_table=11
                     /translation="MPKKLPQAEMPAADYAFYGLVWAGTVMTERVDRALTKAHDLPVSW
                     FEVILWLASSPDPVPASVLGNSTMLSRSQVSRVVDALQARGLVSRTPSARDARSVEISL
                     TDEGHRLFERADATRREVLAPVFTDLLDEHDLEALGTVWRKLKADKERLAQDPVSGPTE
                     "
     gene            18341..19195
                     /locus_tag="AMK32_RS23995"
                     /old_locus_tag="AMK32_23590"
     CDS             18341..19195
                     /NRPS_PKS="Domain: PKS_KR (9-170). E-value: 8.1e-17. Score:
                     53.7. Matches aSDomain:
                     nrpspksdomains_AMK32_RS23995_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007268084.1"
                     /locus_tag="AMK32_RS23995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_23590"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_073895878.1"
                     /sec_met_domain="adh_short (E-value: 9.1e-34, bitscore:
                     112.5, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSATPRTDRTVLITGTSSGIGLAAAVAAARAGWRTVATLRDTTRA
                     DALRKAAAEAGVELDIRRLDVTDEASVAAAIEGVISDYGRLDAVVNNAGAGHLGTLEND
                     SLADVRKVMEVNFFGVLSVSKAALPHLRAVGGRLITVTSVGGVVGQPFNEAYCAAKFAV
                     EGYMESLAPVAGTLGVSVSVVEPGAVATEFVNNIGVDLEAGIDAGAYTGALRHYIDRTV
                     EQFLDGTAQTPAGAAEAVMEALDAERPAFRIQTTDWARAFVGTKLADVDGSAVQALTGS
                     WVG"
     CDS_motif       18368..18412
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMK32_RS23995_0001"
                     /evalue="5.10E-03"
                     /label="PKSI-ER_m5"
                     /locus_tag="AMK32_RS23995"
                     /protein_end="24"
                     /protein_start="9"
                     /score="9.6"
                     /tool="antismash"
                     /translation="TVLITGTSSGIGLAA"
     aSDomain        18368..18850
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMK32_RS23995_PKS_KR.1"
                     /evalue="8.10E-17"
                     /label="AMK32_RS23995_PKS_KR.1"
                     /locus_tag="AMK32_RS23995"
                     /protein_end="170"
                     /protein_start="9"
                     /score="53.7"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TVLITGTSSGIGLAAAVAAARAGWRTVATLRDTTRADALRKAAAE
                     AGVELDIRRLDVTDEASVAAAIEGVISDYGRLDAVVNNAGAGHLGTLENDSLADVRKVM
                     EVNFFGVLSVSKAALPHLRAVGGRLITVTSVGGVVGQPFNEAYCAAKFAVEGYMESL"
     gene            complement(19266..19862)
                     /locus_tag="AMK32_RS24000"
                     /old_locus_tag="AMK32_23595"
     CDS             complement(19266..19862)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018515167.1"
                     /locus_tag="AMK32_RS24000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_23595"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_073895880.1"
                     /transl_table=11
                     /translation="MGKAGTKGVSRAERERQIVDVALEEFGGKGYSGVSVAAVALRAGI
                     SKPLVYSYFDSKDGLYLACVHRVGGLLVDAVAAAGTRSGSAQHALDTLSAIFTAVEDCR
                     YAWAVLYDPALPPAGETRDAVRFYRGRLAAMGAAGAAGLLSHAGHDDPLDHQLLDHVWQ
                     YTVAAVMRWWSDHPDQSAAEMTARCARLLTSLGAG"
     gene            19932..21548
                     /locus_tag="AMK32_RS24005"
                     /old_locus_tag="AMK32_23600"
     CDS             19932..21548
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1261: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018851528.1"
                     /locus_tag="AMK32_RS24005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_23600"
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_073895882.1"
                     /transl_table=11
                     /translation="MTRSWWGWGNVEDAVKGAELKALLERARMLMPGEPTDHEPPDIAS
                     LGLPAPRVTAPASLAGLCSADPADRAAHAHGKAFRDVVRNLQGDLRHVPDLVARPRDER
                     DVVDLLDWCTREGIAVIPFGGGSSVVGGVEPRFDDRPGTVTVDLERLDQVMEIDRTSRA
                     ARIQAGVFGPRLEEQLRPHGLTLRHFPQSFEFSTLGGWLATRAGGHYATLYTHIDDLVE
                     SMRVVTPNGVSASRRLPGSGAGPSPDRLFLGSEGTLGIITEAWMRVQERPRWRAGASVR
                     FGDYAAAVAATRAIAQSGLNPANCRLLDAAEALLNAGADVGGGLLVLAFESADHPVHAR
                     LERALELCRDHGGEPSGVTSAEAPGHAGGEPDRAPGDGSAAENWRSSFLRMPYQRDAMA
                     RHAVIAETFETACTWDRFDALHRAVTEAARQAMYEVTGTGVVTCRFTHVYPDGPAPYFG
                     VYAPGRWGSMVSQWDHIKAAVSEAIETHGGTITHHHAVGRDHRPWYDRQRPGPFAAALT
                     ATKTALDPAGILNPGVLLPAP"
     misc_feature    22567..22581
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.02"
                     /tool="antismash"
ORIGIN
        1 ggttccggca cggtgcacgc cttcgacgcc gacgaggaga ccgtgcggga actccacgcg
       61 gacgtctcct ccctcgtcca ggtcaccctc cggttccagc gcctgctgga ggagttcacc
      121 ttcagcggcg acgacgccga cgaggaagcc gacttcgagc gcctggaggg cgaggtcgag
      181 cgcatcggcc aggagacgag ccgcgtcgac ccgctcccct tccaggacga cgagacggtc
      241 tggtcgatcg tcggcgagga gatcgccgcg ggccagcgct tcaagggcga cagcccggga
      301 gcccgctccc tgtacgggtg atcgccgggg gcggtgcggg aggggcacgt cgatgcgcgg
      361 accccgggaa attcacctga ccgccgcccc cgccctgcgt cacaatgccg ggatgaccga
      421 tgatccctcc cggatgcccg ccgctccgct gctgcgccgt ccgggggacg gtgagctcat
      481 cgacgtcgcc ggtgtcgcgc acttcttccg gctcaccggg gagcacacgg gcgggcggtt
      541 cgccttcgag gagttcgctc tggcccccgg caccgtcggg gccagaccgc acgtgcacga
      601 agggcacgac gagtacttct acgtcctcga aggcgagctg accctgcaca ccggcgacgg
      661 cgaggtgacc gcgggcccgg gccatctcct cgccgccacc cgcggcaccc cgcacggctt
      721 ccgcaacgcg ggaccggtcg tcgcgcgcgc cctctgtctc tacaccccgg ccggctacga
      781 gaactacttc cgcgaggtgc acgcggccgt cagcgccggc gccgaggcga ccgacgagct
      841 gctggccgag ttccgcggcc gccaccggac cacctcccac cccctgccct cggcacggtc
      901 cgagtccgag cccgtcggcc ctgatctccc atgacgcagc ccccgccgcg gctgcgactg
      961 ctccacccgg gccacgcccc cgcactcctc gccttcgaac gcgagaaccg ggcctacttc
     1021 gcgcgatccg ttcccgaccg cggggacgac ttcttcacac ggttcgacga acggctccgt
     1081 gctctgctcg ccgagcagga ggccggcgtc tgccacttcc acgtcctgct cggcggcgag
     1141 ggcgaggtac tggggcgggt gaatctcgtg gacgtggcgg acggcggtgc cgacctcggg
     1201 taccggatcg ccgaacgggc ggcgggccgt ggcctggcca cctgggccgt gcgggcactc
     1261 tgccaccgtg ccgcggaccg gtacgcactc acccacctgc gcgccgcggc gagactcgac
     1321 aaccccgcgt cccgggcggt actggtcaag accgggttca ccgtcgtcgg tgagacacgg
     1381 ctctccggcc accccggtct gacgtaccgg cgcccgctcg gcgaggtccc ggccccgccc
     1441 ccctgacgtg gaccgagcgg gtgccttccc gcccgccgga cggtgtcgcc ccgccgtcgg
     1501 acgcccgcac ctcctagcct cggcggcatg ctacggctac ctccccatat ccgggcctgc
     1561 ctgttcgacc tcgacggggt gctcacccag acggcgaagg tgcacgcggc cgcctggaag
     1621 gagatgttcg acggctatct ccgcgagcgc gctgcccgcg agggcgcgcc gttcgtgccc
     1681 ttcgacgcgg tcggcgacta cgacgagtac gtggacggac ggccccgcga ggacggggtg
     1741 cgcaccttcc tcgccgcgcg cggggtgcac ctgcccgagg gatcgccgga cgaccccccg
     1801 gagtcggaga ccgtcaacgg tctggggacg cgcaagaacg ccctggtgct ccggcggatc
     1861 cgcgaggccg gggtggagcc ctacgagggg tcggtccgct tcgtgcacgc ggtccgcgag
     1921 gccggtctgc gctgcgcggt ggtgtcgtcc agcgcgaact gccgggacgt cctggcggcg
     1981 gccggtatcg atgacctgtt cgacgagcgg atcgacggcg tcgtggcccg cgaccgccgg
     2041 ctgcgcggca agcccgcccc ggacacctat ctggaggcgg cccgcggact ggacaccgag
     2101 ccggacgccg ccgcggtctt cgaggacgcg ctggccggtg tcgaggccgg acgggcgggc
     2161 cggttcggcg tcgtggtcgg ggtcgaccgg gtcggccagg cggagcagtt gcgggcccac
     2221 ggggcggacg tggtggtccg tgacctggcg gaactcctgg agtcgcggtg atcacacatc
     2281 ccagcttcac ggtcgagccg tggtgcctgc gcgagaccga gctgaacctg gaggtgctcg
     2341 cacagagcga gtccgtgttc gccctgtcca acgggcacat cggctggcgc gggaacctcg
     2401 acgagggcga gccccacggg ctgcccggcg cctacctcaa cggcgtccac gagcggcacc
     2461 cgctgccgta cgccgaagcg ggctacggat atcccgagtc cggccagacg atgatcaacg
     2521 tcaccgacgg caagatcatc cgcctgctgg tggacgacca cccgtgcgac ctgcgctacg
     2581 gccaactgct ggagcacgaa cgcgtcctgg acttccggtc cggtgtgctc agccgtaccg
     2641 cacgatggac ctcacccggc ggccgcaccg tccggatcac ctcccggcgg ctcgtgtcct
     2701 tcgcccagcg ggcggtggcc gccgtggtct acgaggtcga gccggtcgac ggaccggcga
     2761 gcgtcgccgt gcagtccgaa ctcgtcgcca acgagcaact gcccaccatc acgggcgatc
     2821 cacgcgtcgc cgccgccacc cggtctccgc tcgtcggcga ggagtacttc gcgcaggaca
     2881 cccggctccg gctcgtgcac cgcaccgagg ccagcgcgct gcgggtcgga gcggcggccg
     2941 accatctcgt cgagggcccc ggaagcaccc gctggacggc ccagtgcgag cccgacgtca
     3001 gccgtctgac ggtgaccgcc gacctggagc ccgggcagcc gctgcgcctg gtcaagttcg
     3061 tggcctacgg ctggtccggc gagcgttccc tgccggccgt gcacgatcag gtcgacggag
     3121 cggtggcggc cgcggtcagc accggctggg acgggctggt cgccgcgcag cgcgcctacc
     3181 tggaccggtt ctgggccggc gcggacgtcg aggtggaggg cgacgcgcag atccagcagg
     3241 cggtgcggtt cgccctcttc cacgtgctcc aggccgcggc ccgcggggag aaccgcgcca
     3301 tccccgccaa gggcctgacc ggaaccggct acgacgggca ctccttctgg gacaccgagt
     3361 cctacgtcct gccgctgctg acgttcaccg caccggaggc cgtggcgccg gcactgcggt
     3421 ggcggcacgg aacgctgccg gcggcacgtg agcgcgcccg ccaactgggg ctcgccggag
     3481 cggtgttccc ctggcggacg atcgagggcg ccgagtgctc cgcctactgg ccggccggga
     3541 cggccgcctt ccacatcaac gcggacatcg cgaacgccgc ggtccgctac gtcatggtca
     3601 gcggggacga ggagttcgac cggggcgagg gactcgacct cctcgtggac accgcccggc
     3661 tgtggcgctc cctggggcac cacgacgccg cgggcgtctt ccacatcgac ggggtgaccg
     3721 gacccgacga gtacagcgcc atcgcgcggg acaacctgta caccaacctg atggcccggc
     3781 agaacctggt cgccgcggcg gacgcggtca cgcgccaccc ggaccgggcc gcggaactcg
     3841 gggtcgacga cgaggaggcc gccgtctggc gggacgccgc ggcccgcatg gccatgccgt
     3901 acaacgacac cctcggcgtc cacgaacagt ccgccggcta cacccacttc cagcgctggg
     3961 acttcgaggc gaccccgccc gagaactatc cgctgctgct gcactacccc tacttcgacc
     4021 tgtaccggaa gcaggtcgtc aagcaggccg acgtggtcct ggcgatgttg gagttcccga
     4081 acgccttcac cgaggagcag aaggcacgca acttcgccta ctacgaagcg ctgaccgtcc
     4141 gcgactcctc actgtccgcc tgctgccagg cggtgctcgc cgccgagacc gggcacctgc
     4201 ggctggccta cgcgtacctg ggcgaggccg cgttgatgga cctcgacgac ctggagcaca
     4261 acacccgcga cggtctgcac atcgcctccc tggccgggac gtggatcgcg cttgtctccg
     4321 gtttcggggg catgcgccgg cacatcggcg aggacggcag gccggacctg ctcgggttcg
     4381 cgccccgcct gcccgaagcg ctctcccggg tcgcgttcac cgtgctgatg cgcggccgcc
     4441 ggctcaaggt cgacatcggg cccacccacg tgcgctaccg gctggtggag ggcgaaccgc
     4501 tggaggtgct gcaccacggg gagccgctca ccgtgaccgc cggagcgccg gtggagcgcc
     4561 cggtgccgcc cgccaccgcc cgtcccgagc cgcagcagcc gcgcggccgg cgccccgccg
     4621 gcctggccac cgaggaggaa caactccggc cggaggcaca ggagtagccc ggagggacgc
     4681 aagaggtggc ataccgggcc ggctcggcgg tcccacgttt gtcccgccgg gtgcgggcaa
     4741 cgcgaagtcc atgactgaat cgaacgatga ctcgagccgg aagtccgcag cggtgcgcga
     4801 gagcgcgtcc aaggcgcggc ggacggcgga caaggcgacg gcaccggccg gccgggcggc
     4861 gaagaaggcc gcgacgacca ccgacggcgc cgtgtcggcc gcgaaggccg gcaccgagcg
     4921 tgcggccggg gcgacgagcg cggccgcccg tacggcggcc cagggcgtcg aatcgggccg
     4981 gcaggcgctg atcacggcct ccggccaggt cgcggccacg gccaagacgg cctggacggt
     5041 catcgcccac cgcaagatga tcgccgccgg tgtgggcgcg ggtctcacgg cgtggaccgc
     5101 cgcgtcctac gcgctggggc gacgctccga gcgccagacg cacggaccgc tcacccgcct
     5161 caccagcgga cggttctgac ccgtccacgg acgcggtccg acatgtccac cggtggacca
     5221 ggacgccccc gctttcccgg acgcaccagg gccggcccat cgttgtcgca caggcgatga
     5281 tgggccggcc ccctgccgtc gtagggccgg tggggccggg gccatgccgt cgcaacggcc
     5341 ggtgggaccg cccccggccg ttcccgcggc agcggtacgg accacggtcg gcgccgcggt
     5401 ccggaccgcg gcgggcggac cggcgggcgc cggaggccgg tccgcctcgt ccacctgggt
     5461 cagccggtct tgctcagccg cgcgacggcc ttggcgagac cgttcaccca gagctggttg
     5521 acgcgggcgc gctccgtgga gttcgggtac cggttggtgc aggacgtgcc ggggccgccg
     5581 cccgacatca gctcgctgca cgggccgctg tagtggtccg gcagacccag cacgtgaccg
     5641 gtctcgtggg cggcgacccg gatcgagtcg tactgccggt tctgcgcgta gtccaggaag
     5701 atgtagccgc tgccgtggcc gtcggtcgac gcgtacgagc cgcgcgagtc gttgccctcg
     5761 tagtaggcga agtccgcgcc gcccgaggtc gcctggagct tgacgttcga cacggagctg
     5821 ttccagatgg acgcggcgct cgatatctgg gagcggaagc tcggcgcctg ggaggcgttg
     5881 tagtagacgg tcaccacctt cagggagggc tgggcggcct gccgcttcgc caccgagttc
     5941 agcacggcgt cgaagaacgc cttgtcgccg gagctctcgg ccgaaccgac gtagccggcg
     6001 gcggaggtgc gggccggggc ctcggcggtg ctccgggcac tcgccggggt cgcggtgccg
     6061 agcgcggcgg aggccaggcc caggccgagc gcgagggcca gaagtctcct tgagttcttc
     6121 ggccggtcgg gcatggggaa cgaagccatg tggggggctc cttctcgtcc tgtggggttg
     6181 aacgatcggt tgccctggag tctccttcag tccaacggga ctgcggatga tggcagttgg
     6241 ggatagtccg gtgctatcgg cgggcggctc gcccctcgcg ccgcccggct cggccgactc
     6301 gtccggattc gttggaactt gaacatctgg tgcaccgacc cactccgccc tacgctccct
     6361 ccatggagtt ggaggtgagg cacctgcgcg ttctctgtgc catcgccgac accggcagcc
     6421 tgcacaaggc ggcacggcaa ctcggcctgg cacagccctc gttgagcacg cagctgcgac
     6481 gtatcgagca tgcgctgggc gccccgctct tcgtgcgcgc ccggaccggc tgccggccca
     6541 ccccgctggg gctcgcggta ctgagccgcg ccaggcccct ggtggcggag ttcgccgcga
     6601 tcgtcacgga gaccagggcg gcggccgccc gcgccgccgg gggcttccag ctgcgcatcg
     6661 gcgccacggc gagccgggcc atcccgggct ggttacgtct gctgcgggcc cgggtcccac
     6721 gcatcgaacc caccctccag atgaacgtct ccgccaactt cctgctcggc atggtcgccg
     6781 cgggacggct cgacatcgcg ttcgtgcacg aggtcgaggg cagtccgctg cgcataccgc
     6841 ccgggctcag cctgcgcgtc ctcgtcgagc gggagccgca gttcgtgacg ctcgcggcgg
     6901 accacccggc ggcggcccgt cggcaggttc cgctcagcga cctggcaggc gaccgctgga
     6961 tggtcgattc cacggtcgac ggggagtggg acgccctgtg ccgggcgctc cgggcggccg
     7021 gactggagtc ggagatgctg cacggcgact atctcaccgc gtactcgctg gccgccaccg
     7081 gcgaggtggt cacggtgagc cagcccaccg cccacccccg tcccgatctc gcgatccgtc
     7141 ccctggaggg cgacccgatc ggcgtacggc tcctgctcgc ggcccgtacg gaggccgaac
     7201 tggacgacgt ctacccggag ttggcggagt cgtactggac ggtggcccgt gacgctccgg
     7261 cctaccggga gtggctggaa cgggcacgcg tgccgctcgt accgctcgac cgcgccgccg
     7321 agcccccgct cggccgacga agaccgggct gtccggccca ggcgcccgcg agaccggcgg
     7381 ctcccagcac ccaccgctga tcgtcgagcc ggcgctcgcc cggacccgcg cgctggtgtc
     7441 cggcgaccct gagtggccac ggcacgaggg ccggacccgg attcaccctc ccgcggttgg
     7501 gccgcgggaa cggtggacac tcggccggca tggacgatga caggccgctc gccctggtga
     7561 ccggggcatc gagcggaatc ggatacgaac tggccggtcg gttcgccgag aacggcttcg
     7621 acctgctgat caacgcggag gacgaccggc tcgaccacgc cgcgcaacgg ctgcgcgagt
     7681 ccggcgccgg cgtacgcgcc gtacgggccg acctcagggc gccggaagga gtggacaagc
     7741 tggtcgcggc caccaccggc ctgcggatcg acgtcgccgt actcaacgcc ggagtcgggc
     7801 agggcggcgc cttcgcggac accgacctgg ccgacgacct cgcgatcgtc gacctgaacg
     7861 tggcctccac ggtgcggctc gccaagccgc tgctgcgcga catgctcacc cggggtgaag
     7921 gccggatggc gttcacgtcc tccatcgccg ccaccatgcc ggggtccttc cagccggcct
     7981 acgacgcgat catgcaggac gaaggcccag ggcctggcga acaaggtcct gccggacagt
     8041 gcgaaggccg ccctgcaccg ctccatggcc gaaccgggaa cggccgagga caccgacgga
     8101 cgcgactgac cggccggtga accgggcgcc gcacggtgac cgcgcgccgg ggccgcccgc
     8161 ccggccacga ggcccgtgcc acgggtgtcg gcggcgacaa ctatgctccc gcgcatgagc
     8221 gatgcgggca gcgacaccag cggcagacgg gttgtggacg ggcgcttcga gctggagaaa
     8281 cggctcggcg gcggcggtat gggcatggtc tggctggccc gcgacctgat gctgcaccgg
     8341 cacgtggccg tcaaggaggt ccggccggcc gaccccgacc tcgcggagta cgacccggag
     8401 gcggcgcggc agctgcggga acgggtcctg cgggaggccc gcgccctggc ccgggtggac
     8461 caccccaacg tggtgacgat ccaccacatc gtcgacggcg gcgcgggcgg cttcccctgg
     8521 atcgtgatgg agctcgtcac cggcggctcc ctggccgatc gcctcgcccg cgggccgatg
     8581 gacccgcggg aggcggcact gctcggacgg gaggtgctgg cggctctgag cgcggcgcac
     8641 gccgcgggca tccagcaccg tgacgtgaaa cccgccaacg tgctcctgcg gcccgacggg
     8701 cgcccggtgc tcaccgactt cggcatcgcg gcgatccgcg agtccacggc gctcaccgcg
     8761 accggatcgg tgatcggcac cccggactac atggccccgg aacgcgtctc gggccacgac
     8821 ggcgggcccg cctccgacct gtggtcgctg ggcatgatgc tctacacggc cgtggaaggc
     8881 cggcatccgc tgcgcagggg ttcgacgttg gcgaccctcg cggccgtcat cagcgaggac
     8941 atcccgccgc cggtccacgc cggcgcgctg accgacgtcc tggcccgggt cctcgtccgc
     9001 gaccccgccg cacgtcccgg cgccggtgag ctggagcgca tgctggaggc cgcggcccgc
     9061 gacgccggaa caccgccgac gtcgtaccag ctgcagccgc cgcccgtcga accaccgcac
     9121 cccgccccga cgacggtgac gcccggtgcg ccgggtcccg gccacaccac ggcggcggac
     9181 ggcttcggcc cggcgcccgt gatgctcccg gggccgtacg gcggcacggg gcagacggtg
     9241 gcaccgggtc ccgaggacgc gcggccgggg tcgacgacca tgcccgtgcg ccgcggacgc
     9301 ggccggcgct ggaccctggt gaccgtgccg gtcgtgggag tggcgctcgc cggcaccctc
     9361 atgtggacgc tgcggccgga cgggggcacc cacgactcct cctccgggtc ggggtcctcg
     9421 cactccgccg acgccaccac cggggcggcg acaccgaccg ggccggcccg cgtctccgcc
     9481 tctccggcag gaaaggaaca gacgaccggc aagagcctgt tgaccccgga cggcatccgc
     9541 accgccgtcg aggcgatcaa gaaggcgaca ggccgggacc gcttcggcag cctcacggtg
     9601 tacccggagt acgtctccgc cgacgtgatg gtgaagggca gcgacaccaa gtacgactcg
     9661 tacacctacc gtcccgggca ggaggtggag gaaggcatca tccacggcaa gctgaccctc
     9721 ggcgacgccg ccatcaccct cgacggcttc gactgggacg cggtcccggc gctgatccgc
     9781 gaggcggaga agaagctgaa cgtcgaccac cccaagacgc gctacctggt gctggaactg
     9841 gcggacgacg ccttcggcac tcccgacggc atggccgtgt acctgagcga cgactacggc
     9901 accggctacc tccaggcgga ccgcaagggg aaggtcgtac gggtgatgcc cgccgacggc
     9961 tgaggggcgc cccggcccgg gcgccccgcg tcggcgcggg ctagtcgagg agcaggggat
    10021 cgggcaggga cgccgaccgg tgcatgcaca gcagggtgtg cacgacgccc gagagtcccg
    10081 acatcaggct cggggagaac gcctcgcggg ccagcccgcc gacgggaccg cgctgttcca
    10141 ggccggtgag gatctccccg tccaggtcgt caagggtgcc gagaccgtcg gcgccttcac
    10201 cgcccatgga cgtgaggaac cgccagaggc ccaggtcgcc gtggcacagc gtgtggctcc
    10261 agccgaagcc ctcggcggcg caggcacggg cggcccggcg ggccatgtcg aggtgggccg
    10321 gctcgcccgt gcgccggtgc aggtcgagca tgccgatccc gacgcccgcg ctgccgtggc
    10381 accagctggt gaagaagtcc tcctcggcgc cgtcgcggat gtcgagccag ttgcccgcgt
    10441 cgggctgcca cagggactcc tggaagtcga aggcccgctc ggcgatgtgc cgccaggccc
    10501 gccgctccgc cggggtgccg gccccgctga gcgcgagcct ggccagcgcc cagccgatgc
    10561 cggtggcgcc gtgcgcgaac ccgccgatgc cctcggggtt cagccgggtc gtccagcgcg
    10621 cgccgccgga gtcgacggcg gcgagccgga tcagccggcg gccgatgtgc gcggcgacgg
    10681 acagccagcg gtcctgaccg gtggcctcgg ccaggccgat cagcgggacg atgccgccgg
    10741 cggccccgtt caggagatcc acctcgacgt cgtcgtcgac gaggcgccct tcgaggagta
    10801 cggcccgttg ggcggcccgc gccagcggcc acggctcgtc gaggacccgg tgcagcgcca
    10861 gccatgtcca cacctgcgag gcggccccgc tgaacgcgcc cgccgacggc gtgggtgtcc
    10921 ggtcctcggt gccgatcagc acgcgcagcg cgccctcgaa ggtctcctcg acgcccggta
    10981 cctcgtccgc ccggccggcg cggacctcgt gcacgtactc cgcgagcgtg agcgccaccc
    11041 cgccctgccc ggtgtagagg tcggcgggca gcaccctgat ggaccatccc gccggggtga
    11101 agaccgggct gatccaggtc accgtgccgt ccgcgccccg caccgccccg tcgcacagtc
    11161 ggcgcaccat cgccgcggcc agccgccgcc ggcgtggctc ccggtcacgg gcgtgcggtc
    11221 gctcggcggc gacccgcacc cgtgcgggca gggaccgctc gttgaggtac gcgcccacca
    11281 gggcgtcctg gatcaccgac tcctccagcg cgaagtcggc ggtgcgccag tcctcgacgg
    11341 tgttccgtac gacggtcccg tccacggtga aggcgaacag cggcacgtca ccggccagca
    11401 ggtcggcgat ctcgccgtcg atggtcccgg tgtccgtcgg cgcgcccggc agcacctcgg
    11461 cgttgcgccg caggatgtcc cgggcccgtg ccacggccgt gtcctcgtcg tgcagcgacg
    11521 ccgggtgcca cagcatccgc ccgatgtcga cataggcctg ggtcggccgc cggatccgcc
    11581 gcacgcgggc cccttcgaag cggtgcagca gccggagcgg gtccacctcg tcgcgccgca
    11641 gatgggcggt catctcctgg aagccggcca ggatccggtc ccagtaggtg ctcagcacgg
    11701 gggtcgggct cgggtggttg cccgccgtgg gcatcgccac caggtccacc tcgaagcggg
    11761 ccgccgcggc accgccctcg gcgatcaccg ggttggggat cagcggctgc tggccgggca
    11821 gcgcgccgac gccggagatg tccaccccgc ccagcgcgaa tccggtgccc cgcactggca
    11881 gcagcccggt gcgcagcacg gtccggcgga tggccgccgc caggtcgacc gcgtccccgc
    11941 ggccgctggg cgggaagggg gcgggggcgt cgaagagcgt ctcggcgtcc acgatcaccg
    12001 gcaccggacc cgccgcgatc atgttctcgg cgtgcatgtc ggtgccaccg gtgaagcgga
    12061 gcacggcgag ccagtgcccc atgttgcggt agaaggcggc gagttccgtg tcgtccgcgc
    12121 agtagcggtg ctccacgaac tcggcccatc cgtagccctc gcgcgggagg gtgcggggca
    12181 cccggatccg ctcgtcccga gggggtgcct cggggaagtc cgcgaacagc tcctccagca
    12241 tggcgccgag ggcgacgtcc acctcggacg ggcgtggctt gtacatgacc gtcccgccgg
    12301 tgaggtcgag ccggctgacg gtcaggccgc ctccgtggct gtcgcccgcg ccgaaggtga
    12361 cggccccgag gcggcccgcg ggtgcgccga gcagcggcgc gagcaggtcc cggtcggcgg
    12421 cgaggcgttc ggcgagggcg gccgtggccg ccaccgacat ccgggcgacg acggcgacgc
    12481 gccgcccgag gctcgggtag cggccggcca gcttgtccag gtagccctca gctccggcct
    12541 gttcgacgaa cgcgttccag gtggcggtgt ccggggcgcc ggggcgcccg gcgtccggaa
    12601 cgccctgcgc catgcgcagg gcgtgcagtt cgacgaggaa cagccgggtg agcttcgcgt
    12661 gcagggagtt gagcagtgcg gtgtggccgg cctccagcag gacgtcccgc tcctccccgt
    12721 gcagtgcggt cacggccgcc aaccgccggg ccaggtcctc ccgccacgga cgcgcgatgc
    12781 cgcgcacggg accgtcgaac cactccgccc gttctccgcc gtccgctgcc gatgcgttca
    12841 cccgccaccc tccctgcttc ttcggacggc acgcgcccat tcggacgcgt gccgggaaaa
    12901 cacgggaggt cagcagcacc agctgccgcg cgacccgctc gggctggagc agaagccgta
    12961 cagggagtcg ctcgggtcgg tgagcgcggc ctccgcggcg gtgcctccga cgtacagcgg
    13021 gccggcgggg ttgagctcgc cgtacgcggt ctcggcaccc gacaaccagg cttcgagcac
    13081 cgcggccgtg cgcacactgt tctgagacat gggtggcctc cgaattcgcg agtgagggcg
    13141 gttcgcccag cccgagtatc gccgtgttcg acggcccgtc agccgatcaa tcaagccact
    13201 gtggtgcggt ggtccacggg ggagccgggg ctgctgggac gggggagggg cgtccgatgg
    13261 caccagtccg actcgcgcgg ccgcccggca gcaccgacga tgagtccaag atctcctcgt
    13321 gcacgttccc cacctgcaag gaagaccgca tgccctccca ccgccggacc ggcctcctca
    13381 gcgttcacgt tcgtcctcgt tccctggcat cgatcacctt gacgtgttgc tgcctcgtgg
    13441 cagcgggcgc gctcaccggt tgcggcaacg gcggcggtgg caccggctcc accgccagcg
    13501 cgacgcccac cgccccggac acggcctcgt tcagcggggc gccgccctcg gcgctcgcct
    13561 cctccgcgtc ctcggccatc gcctcggccc gggagtcggc atcggcggcc gcctcctcgg
    13621 cgtcggcccg cgccgaggag ttcgaggcct cggtgtcggc cgagttcgag cgcaggaccc
    13681 aggcggccca gaacgcgctc aagggggtca agggcagcgg caacgcggtg tccgacgtcg
    13741 gcatgaccgg cattcccaag gcgcagaccg ggggagtgct cgccgtgctg gtgaccatca
    13801 ccaacaagac gagccagaag gcgtcctacg ccgtgcagat cgacttcgag gacgcggacc
    13861 accacgtcgt ggagaccagg tacaccggcg ccgagaacct cgaacccggg aagaaggaac
    13921 agcccatcgt cttcagccac cagcagtccg agcagaatct cacccctcgt ctggccaagg
    13981 cccagcgcta ctgacccacc gaccggccgg cccgctcggc ctcccggaca gggcggtcag
    14041 aaggcgtagc ggatgcgaag ccacggcgcg tgggccgcga ccagcgtgcg cacggcctgt
    14101 acggcctccg ccttgacgcg gtggtcgtac cggacgttca ccgccccgtt ctcggagcgc
    14161 ttcgcctcct gcaggcccgg ctgccacagc acctcctcgg cgcgcggatg ccagccgagg
    14221 ttgacctcgt gcagttcccg gttgtgggtc agcatgatca cttcggcggc cgcctgctgt
    14281 ttgacccggt ccggcaggac gtcgtcgagc tgccgcagca cttcggccca cgcctccttc
    14341 cagccggggc gcaggacgac gggcgagagg ttgaagtgga cctcgtagcc cgcgtccagg
    14401 aagtccgcgg cggcggcgat ccgctcgccc acaggtgagg tgcgcacgtc cagcaggcgc
    14461 gagtcctcgg cgggcatcac cgagaaccgg acgcgtgtcc ggccgcgcgg gtcgagcgcc
    14521 agcaggtcgg ggttgacgta cttggtggcg aaggaggcct tcgcggtcgg ccactgacgg
    14581 aaggcgtgta ccaggtccgc ggtgttgtcg cagatcagcg cgtccacgga gcagtcgccg
    14641 ttctccccga cgtcgtagac ccaggccgtg tcgtcgcact ggttgggctc ccgcttgggg
    14701 ccctggcgcg cgatgtgccg ccccaggtgg gcgatgatcc ggtcgatgtt ggtgaagacg
    14761 gtgacggggt tcgcgtaccc cttgcggcgc ggcacgtagc agtacgcgca ggccatcgcg
    14821 catccgttgg aggcgccggg ggcgatccag tcggcggacc gtccgttcgg ccgggtggtc
    14881 agcgacttcc gctcacccag gacgagggtc tcgcccttca cccggaccca gcgctcgacg
    14941 ttgccctcgt tgccgtgcag ccccgggatg cgccagtggg agtccacctc caccacgttc
    15001 gcggccggga accgggcgag gatctcgcgg ccgcgcgggg acgcagcggc cgcgggctcc
    15061 gcgtagacgt gccgcaccgg cagcagacgg cgcgccgcgg gcgagtcgcg gaacggggcg
    15121 cggccctccg gcaggcgcgc cgggcctgtg ccgcccccgc cgggcgtggc ggtaccggcc
    15181 agcgcgtcga gaccgaacag ggcgtcggag tcgccgtccg gtccggcggt ggggtacggc
    15241 atcgtgtgct ccgctcggcg tgggggagga atggcctgaa tcaggtccaa gcacccaccg
    15301 tacgtgaggc ggcgcgccga cccgcggcgc gcgcccggct caccggccgt cggccggtcc
    15361 gtccggccgg gcggaccggc gacgggcggt gccggaccgc gccggcgcga gttgtgcggc
    15421 tgcgccgtcc agcagggtgt ccaggacggt cgcataggcg ctgtgcggca tgcgggcggc
    15481 cagcaggggg gcggtcgcgg cgatgtgcgg atagctctcc gcgggcagcc gggcgtaggt
    15541 ggaggtccac atgtcctcgt ccgccgcacg ggcctcctcc gtgagggcga gcgctccggc
    15601 gtcgagggcc acgaaggcca ggctcagatc gatgaaggcg tggtagagcc ggacggcggc
    15661 gggatcgggg aagcccgcgg agcgcaggat gcccaggatc gtctcgtcga ccgcgatctc
    15721 ccggggccgg cccgacaccc ggctcgcggt cagggcggcg gcgtgcgggt gggcgaggta
    15781 cgcggagtgg atggccaggc cgagggcgcg caggtccgcg cgccactcgc cggtggcggt
    15841 ccagctgtcc agcgcccgcc ccatcagctc ctcgccgatg gcccgcgtca ggtcgtccat
    15901 accgccgaag tagcggtaca gggtgctcgg gtccgcgccg agcgcggtgc ccagcctgcg
    15961 tgcggtcagg ccggcgctgc cgtgctcgcg cagcacccgc agcgcggtcc gcacgatcag
    16021 cgcctcggac agcaccgtgc cctgctgggt cggccggcgc ctgcgccgcg ccgcctcggg
    16081 caccacctgc ttggccatac ggaccactcc tcttcggcgc gccacgaccg cgctccttat
    16141 gccaacgcag ttgactttac cttgagcggt cccgttgcat cggggcgtcc cgcaaaggcg
    16201 ggtgccttgc ggagaaaggt gtcggacatg cgagtacttc tcgtgggcgc gggcggtgtc
    16261 ggaaccgcgg tcacccggat cgcggcccgc cgcgacttcc tggcccacat ggtcgtggcg
    16321 gactacgacc tgagccgggc cgaggcggcc gtcaccgcgc tgaaggagcg gggggaccgc
    16381 ttcagcgccc gacgcctgga cgcctcggac gaggacgggg tgcgccggct gctcgcggag
    16441 gagcgctgcg acgtcctgct caacgcgacc gacccgcggt tcgtgatgcc cctgttccgc
    16501 gcggcgctcg cggcgggcgc gcactacgtg gacatggcca tgtcgctgtc cgccccgcat
    16561 gccgaacgcc cgtacgagga gtgcggcgtc aagctgggcg acgaccagtt cgcactggcc
    16621 ggccgctggg ccgagtcggg ccggctcgcg ctggtcggca tgggtgtgga acccggcctg
    16681 tccgacgtct tcgcccggta cgccgccgac gaactcttcg acgagatcga ggagatcggc
    16741 gtccgcgacg gggccaacct gaccgtcgag ggctatgact tcgccccctc cttcagcatc
    16801 tggaccacca tcgaggagtg cctgaacccg ccggtggtct acgagaagga ccggggctgg
    16861 ttcaccaccg cgccgttcag cgagccggag gtcttcgact tccccgaggg catcggcccg
    16921 gtcgagtgcg tgaacgtgga gcacgaggag gtgctgctca tcccgcgctg ggtggacgcg
    16981 cgccgggtga cgttcaagta cggcctcggc gacgacttca tcgccaagct gaagaccctg
    17041 cacgagctgg gcctggactc caccgcgaag gtcggcgtcc cgggtgagga cggggccgtg
    17101 cgggtctccc cgcgggacgt ggtcgccgcg tgcctgccgg acccggccac cctgggcgac
    17161 cggatgaccg gcaagacgtg tgccggcacc tgggtgaagg gcacgaagga cggcgctccc
    17221 cgcgaggtgt acctctacca cgtggtcgac aaccggtggt cgatggacga gtacggctcc
    17281 caggccgtgg tctggcagac cgcggtgaac ccggtcgtcg ccctcgaact cctcgccacc
    17341 ggggcgtggt cgggcaaggg ggtcctcggc cccgaggccc tgccgccccg cccgttcctc
    17401 gacctgctca ccgagtacgg cactccctgg ggcctgcgcg agcagggctg aggcccggct
    17461 cctcggccca caccgccacg agagaggtgg gggccgggac gacgaagccg cccgccgggt
    17521 gtgccccggg cgggcggctg ctgccgtagc tgttcagaga tcgaggtcgg cggcggctga
    17581 ggtgtcctgg gccgctggac gacaccggca cgaagccggt gacgggattc gaacccgcgt
    17641 ttcccgctgt gcaggcgaag tagccgctgc ctgcgcacct gaacgatcac caccctagtg
    17701 cgcggccgct ccgcggggca cctcatttac cggcgcggtc acgggcgtca ctcggtgggc
    17761 ccgctcaccg ggtcctgcgc cagccgctcc ttgtccgcct tgagtttccg ccacaccgtg
    17821 ccgagcgcct ccaggtcgtg ctcgtcgagg agatcggtga acaccggcgc caggacctca
    17881 cggcgggtgg cgtcggcccg ctcgaagagg cggtggccct cgtcggtcag cgagatctcg
    17941 accgaccgtg cgtcacgcgc ggacggggtg cggctgacga ggccgcgggc ctggagggcg
    18001 tcgaccaccc gcgagacctg gctgcggctg agcatggtgc tgttgccgag gacggacgcg
    18061 ggcaccgggt cggggctgga ggccagccag aggatgacct cgaaccagga caccgggagg
    18121 tcgtgcgcct tcgtgagggc ccggtcgacc cgttcggtca tcacggtgcc ggcccagacg
    18181 agcccgtaga aggcgtagtc ggcggcgggc atctcggcct ggggcagctt cttcggcatg
    18241 cgtcgaagta taggcggggt tgcgtgcgca cacacataaa gctatgttgt gtgtgcacgc
    18301 acataaacca gcgtgtttcg atcgtccgaa aggccccgcc atgtccgcca ccccccgcac
    18361 cgaccgcacc gtcctcatca ccggtacctc ctccggtatc ggcctcgccg cggccgtggc
    18421 cgccgcccgg gcgggctggc gcacggtcgc caccctccgc gacaccacac gcgccgacgc
    18481 gctgcgcaag gccgccgccg aagcgggcgt ggagctcgac atccgccgcc tcgacgtcac
    18541 cgacgaggcc tcggtcgccg ccgcgatcga gggtgtgatc tccgactacg gccgcctcga
    18601 cgccgtcgtc aacaacgcgg gcgcagggca cctcggcacc ctggagaacg actccctcgc
    18661 ggacgtccgc aaggtgatgg aggtcaactt cttcggtgtg ctcagcgtct ccaaggccgc
    18721 gctgccccac ctccgcgccg tcggcggccg cctgatcacc gtcaccagcg tcggcggtgt
    18781 cgtcggccag ccgttcaacg aggcctactg cgccgcgaag ttcgccgtcg agggctacat
    18841 ggagagcctg gcccccgtcg ccgggacgct cggtgtgagc gtgtccgtcg tggaacccgg
    18901 cgccgtggcg accgagttcg tgaacaacat cggcgtcgac ctcgaagccg gcatcgacgc
    18961 cggcgcgtac accggcgcgc tgcgccacta catcgaccgc accgtggagc agttcctgga
    19021 cggcaccgcg cagaccccgg ccggtgcggc ggaggcggtc atggaggccc tcgacgccga
    19081 gcggcccgcg ttccggatcc agaccaccga ctgggcccgc gccttcgtcg gcaccaagct
    19141 ggccgacgtc gacggctccg ccgtgcaggc cctgacgggc tcctgggtcg gctgaccggt
    19201 cgcgcgatcg cgcggccgtc cggccgggcc cgcgcgcggc ggcggttccg gcaccgggac
    19261 gcgggtcagc cggcgcccag tgaggtgagc aggcgggcgc agcgggccgt catctcggcc
    19321 gcgctctggt ccgggtggtc ggaccaccag cgcatcaccg ccgccaccgt gtactgccag
    19381 acgtggtcca ggagctggtg gtccagcggg tcgtcgtgcc cggcgtgact gaggaggccc
    19441 gccgcgccgg ccgcgcccat ggccgccagg cgcccgcggt agaaccgcac ggcgtcgcgc
    19501 gtctcaccgg ccggcggcag ggccgggtcg tagagcaccg cccaggcgta ccggcagtcc
    19561 tcgaccgcgg tgaagatcgc ggacagcgtg tccagcgcgt gctgcgccga tccgctgcgc
    19621 gtcccggcgg cggccacggc gtccaccagc aggccgccca cccggtggac gcaggcgagg
    19681 tacaagccgt ccttggagtc gaagtagctg tacaccagcg gcttggagat ccccgcgcgc
    19741 agcgcgacgg cggcgacgga cacccccgag tagcccttgc cgccgaactc ctccagtgcc
    19801 acgtcgacga tctgtcgctc ccgctcggcg cgggagacgc ccttcgttcc ggccttgccc
    19861 atgggccgac cctaccccac gatatgactg aagagtaatt tacccatggg tcaattgacg
    19921 ggagtggtgt catgacgcgg tcgtggtggg gctggggcaa tgtcgaggac gcggtgaagg
    19981 gcgccgaact caaggcgctg ctcgaacgcg cgcgcatgct gatgcccggg gaaccgaccg
    20041 atcacgagcc gccggacatc gcctcgctcg gcctgcccgc gccccgggtg accgcgcccg
    20101 cctccctggc cggcctgtgc tccgccgacc cggccgaccg ggcggcgcac gcgcacggca
    20161 aggcgttccg ggacgtggtg cgcaacctcc agggggacct gcgccatgtg ccggacctcg
    20221 tggcaaggcc gcgcgacgag cgggacgtcg tcgacctcct cgactggtgc acgcgcgagg
    20281 gcatcgccgt catcccgttc ggcgggggca gttcggtggt cggcggggtc gagccgcgct
    20341 tcgacgaccg ccccggcacg gtcaccgtgg acctggaacg actggaccag gtaatggaga
    20401 tcgaccggac cagccgggcc gcgcgcatcc aggcaggcgt gttcggcccg cgcctcgagg
    20461 agcagctgcg cccccacgga ctgaccctgc gtcacttccc gcagtccttc gagttctcca
    20521 cgctcggcgg ctggctcgcc acgcgcgccg gcggccacta tgcgacgctg tacacgcaca
    20581 tcgacgacct cgtcgagtcg atgcgggtgg tcacgccgaa cggggtcagc gcgtcgcggc
    20641 ggctgcccgg ctccggcgcg ggaccgtcac cggaccgcct cttcctcggc agcgagggca
    20701 cgctgggcat catcaccgag gcgtggatgc gggtgcagga acgtccccgc tggcgggccg
    20761 gggcgtcggt ccggttcggc gactacgcgg cggcggtggc ggccacccgg gcgatcgcgc
    20821 agagcgggct caacccggct aactgccgcc tcctcgacgc cgccgaggcc ctgctcaacg
    20881 cgggcgccga cgtcggcgga gggctgctcg tcctcgcctt cgagtcggcg gaccacccgg
    20941 tccacgcccg gctggagcgg gccctggaac tgtgccgtga ccacggcgga gagccgtcgg
    21001 gcgtcacctc ggccgaggcg cccgggcacg ccgggggaga gccggaccgc gcccccggcg
    21061 acgggtccgc ggcggagaac tggcgctcgt cgttcctgcg catgccctac cagcgcgacg
    21121 cgatggcccg tcacgcggtg atcgccgaga cgttcgagac ggcgtgcacg tgggaccggt
    21181 tcgacgcgct ccaccgggcg gtcaccgagg cggcccggca ggcgatgtac gaggtcaccg
    21241 gcaccggcgt ggtcacctgc cggttcaccc atgtgtaccc cgacgggccg gcgccgtact
    21301 tcggcgtgta cgcccccggc cgctggggca gcatggtgag ccagtgggac cacatcaagg
    21361 cggcggtgtc cgaggcgatc gagacgcacg gcggcacgat cacccaccac cacgcggtcg
    21421 gccgcgacca ccgcccctgg tacgaccgcc agcgccccgg cccgttcgcc gcggcactga
    21481 cggccaccaa gaccgccctg gacccggccg gcatcctcaa ccccggcgtg ctgctgccgg
    21541 ccccgtgaac cgtgtgccgg ccaccacagg cgtgccgtgc cggtccggtc agaccggcgc
    21601 ggtgaaggtg tagccgcccg cgggcacgtg gtaggtcgcc gaacccgtcg ggacggcctc
    21661 ggcgggggcc gtgaccgact gcgggcggga ggtggggacc gtgaccgtgg cgaaggtgtt
    21721 ggccggcacc gtcacccgca gggtgagccg ggtgccggtc accgaccagg cgctcgccgc
    21781 ggtgccgaag ggcgtgtcgt aggtggtgtc ggcggacgtg agcccgccgc ccggccgcgg
    21841 agcgatacgc agggaggcgt agcccggact cgcggggccg agtccgccga cgtaccggta
    21901 gaggaagtca ccgaccgagc ccaggccgta gtggttgaac gagttcatgc cgggatcgtt
    21961 gaaggagccg tcggtacgga tgccgtccca gcgctcccag atcgtggtgg caccgtggtc
    22021 gatcatgtag ccccagccgg ggaaaccgcg ttgcagcagg atgcggtacg ccgtgtcggc
    22081 gtgcccgtgg tcggccagca cgggcagcag gtgctcgacg ccgaggaagc ccacgctcag
    22141 atgcccgtcg ttcgcggcga ccttggcggc cagcctgtcc gctaccggct ggaccaggga
    22201 cgccgggagc agttcgaagg ccagggccag cacgtggccg gtctgggtgt tgccgcgcac
    22261 cgtgccgtcg ccggagacga aacgggcgct gaaggcggcg gccacctggt cggcgagccg
    22321 tccgtacgac gtggcctcgg ccttgcggcc ggtggcggcg gccatgcgcg cgaccagccg
    22381 ggccgaacgg gcgaagaagg cggtgcagat gaggtcctgg gcggtgttgt cgttgacgtt
    22441 gagccagtcg ccgtaggtct gctgattgcg tatcaggtca ctgccggagg tgccgcgcag
    22501 gtagtccacc catttcgcca tggccgggaa gtgccggtcg gcgacgctga ggtcgccgaa
    22561 gcgctgccac agcgtgtagg ggatgatcgt gcccgcgtcg ccccagccgg cggtgcccga
    22621 gccgttgatc accgcgggcg cgacgtcggt gaaggcgccg ttggcctgct gggcgtcgac
    22681 caggtcgtcc gcgaacttgg cgaggaaggt gtgggtgtcc aggttgaacg tggatgtcgc
    22741 acagaacgcg gcgatgtcgc ccgtccagcc cagacgttcg tcccgctgcg ggcagtcggt
    22801 cgggatggag agcatgttgc tgcgctcgcc ccagacgatg t
//
