LOCUS       NZ_LIWA01000001        21086 bp    DNA     linear   CON 28-MAR-2024
DEFINITION  Streptomyces sp. CB01883 scaffold1, whole genome shotgun sequence.
ACCESSION   NZ_LIWA01000001
VERSION     NZ_LIWA01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CB01883
  ORGANISM  Streptomyces sp. CB01883
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 2031838)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2031838)
  AUTHORS   Yan,X., Ge,H., Hindra,F., Yang,D., Huang,T., Crnovcic,I. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-AUG-2015) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2014
            Assembly Method                   :: CLC Genomics Workbench v. 7.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905855.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:34:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,089
            CDSs (total)                      :: 8,009
            Genes (coding)                    :: 7,788
            CDSs (with protein)               :: 7,788
            Genes (RNA)                       :: 80
            rRNAs                             :: 3, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 221
            CDSs (without protein)            :: 221
            Pseudo Genes (ambiguous residues) :: 0 of 221
            Pseudo Genes (frameshifted)       :: 85 of 221
            Pseudo Genes (incomplete)         :: 169 of 221
            Pseudo Genes (internal stop)      :: 25 of 221
            Pseudo Genes (multiple problems)  :: 50 of 221
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:33:31
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1403035
            Orig. end                         :: 1424121
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LIWA01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21086
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21086
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21086
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11086](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11086
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(245..1573)
                     /gene="aroA"
                     /locus_tag="AMK32_RS06410"
                     /old_locus_tag="AMK32_06340"
     CDS             complement(245..1573)
                     /EC_number="2.5.1.19"
                     /GO_function="GO:0003866 - 3-phosphoshikimate
                     1-carboxyvinyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="aroA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674885.1"
                     /locus_tag="AMK32_RS06410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_06340"
                     /product="3-phosphoshikimate 1-carboxyvinyltransferase"
                     /protein_id="WP_073889362.1"
                     /transl_table=11
                     /translation="MAPNTASTALWPAPHASRAVDATVHVPGSKSVTNRALVLAALASE
                     PGWLRRPLRSRDTLLMAGALRAMGVEIEETVSSSSSGGGAGEAWRVLPTGLRGPATVDV
                     GNAGTVMRFLPPVAALADGPIRFDGDPRSYERPLHGVIDALRHLGARIDDDGRGALPLT
                     VHGGGALDGGPVSIDASSSSQFVSALLLSGPRFNQGVEVRHTGTALPSMPHIRMTVDML
                     RAVGAQVDTPESGGEPNVWRVTPGALLGRDLTIEPDLSNAQPFLAAALITGGKVLIPDW
                     PARTTQPGDRLREIFTEMGGSCELTEFGLVFTGSGAVHGIDVDLSDVGELTPGIAAVAA
                     LADSPSTLRGVAHLRLHETDRLAALTKEINELGGDVTETADGLHIRPRTLHGGTFHTYE
                     DHRMATAGAIIGLAVEGVRIENVATTAKTLPDFPELWTGMLGQ"
     gene            complement(1602..2324)
                     /locus_tag="AMK32_RS06415"
                     /old_locus_tag="AMK32_06345"
     CDS             complement(1602..2324)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674886.1"
                     /locus_tag="AMK32_RS06415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_06345"
                     /product="M50 family metallopeptidase"
                     /protein_id="WP_073889364.1"
                     /transl_table=11
                     /translation="MDSLAATALPDVWDRLTGTQSDPDLWVVLATLAAALAVVVPGTLW
                     RISRNAITIAHEGGHGLVALLTGRQLTGIRLHSDTSGLTVSRGKPYGLGMILTAAAGYT
                     APSLLGLGGAALLAAGRITLLLWAATALLVVMLVMIRNAYGVLTVVLTGGAFLLVSWLT
                     GPQVQAAFAYAVVWFLLFGGVRPPFELQAKRSRGGAGDSDADQLSRLTHVPAGLWLFLF
                     HAVSLCSLIGGGRWLLEG"
     gene            2429..3244
                     /locus_tag="AMK32_RS06420"
                     /old_locus_tag="AMK32_06350"
     CDS             2429..3244
                     /GO_function="GO:0003697 - single-stranded DNA binding
                     [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009432 - SOS response [Evidence IEA]"
                     /GO_process="GO:0018142 - obsolete protein-DNA covalent
                     cross-linking [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980380.1"
                     /locus_tag="AMK32_RS06420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_06350"
                     /product="SOS response-associated peptidase"
                     /protein_id="WP_073889365.1"
                     /transl_table=11
                     /translation="MCGRYASSRGPEDLAGVFEIEKWEPEETLEPDYNVAPTKEVYAVL
                     DRPVKDADSPRPVRQLRKLKWGLVPSWAKTPEGGARMINARAETVHEKPSYRRAFATRR
                     CILPADGYFEWVTGKQERDLEEEGRKKRPRKQPYFVLPADGSVFAMAGLYEFWRDRTLP
                     DDHPQAWWVTCSVITTEAERTPLAVAPAEGPRSLTEIHPRMPLMLTPDRWDAWLDPART
                     DPEDLRGLLAPPPAGLMRAYPVSTAVSNVRNNGPELLKELEGPEEGTLF"
     gene            3246..3893
                     /locus_tag="AMK32_RS06425"
                     /old_locus_tag="AMK32_06355"
     CDS             3246..3893
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019522885.1"
                     /locus_tag="AMK32_RS06425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_06355"
                     /product="alpha/beta family hydrolase"
                     /protein_id="WP_073889367.1"
                     /transl_table=11
                     /translation="MSTESDTTTETVATQAGDARITWHRAKRARLVLAVSHGAGGGIEA
                     RDLRALARVLPGHGVSVALVEQPWRVAGKKLAPAPKTLDAGWRGLWPALVGPGLPVVSG
                     GRSAGARVACRTAGELGAHAVLALSFPLHPPGRPERSRAAELLGTGVPTLVVQGGNDPF
                     GRPAEFPAGDFALVEVPHGDHGFAVPKRAETTQERALEIITESVVEWAASLG"
     gene            4150..4845
                     /gene="sigR"
                     /locus_tag="AMK32_RS06430"
                     /old_locus_tag="AMK32_06360"
     CDS             4150..4845
                     /codon_start=1
                     /gene="sigR"
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973756.1"
                     /locus_tag="AMK32_RS06430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_06360"
                     /product="RNA polymerase sigma factor SigR"
                     /protein_id="WP_198960315.1"
                     /transl_table=11
                     /translation="MGPVTGTDAGTDNGQAELPEGQGVSAEESSESTAERSARFERDAL
                     EFLDQMYSAALRMTRNPADAEDLVQETYAKAYASFHQFREGTNLKAWLYRILTNTFINS
                     YRKKQREPQRSAAEEIEDWQLARAESHMSTGLRSAESQALDHLPDSDVKEALQAIPEEF
                     RIAVYLADVEGFAYKEIADIMGTPIGTVMSRLHRGRRQLRGMLEDYARERGLVPAGAGE
                     SNEAKGSGS"
     gene            4842..5144
                     /gene="rsrA"
                     /locus_tag="AMK32_RS06435"
                     /old_locus_tag="AMK32_06365"
     CDS             4842..5144
                     /GO_function="GO:0016989 - sigma factor antagonist activity
                     [Evidence IEA]"
                     /GO_process="GO:0045454 - cell redox homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rsrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136687.1"
                     /locus_tag="AMK32_RS06435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_06365"
                     /product="mycothiol system anti-sigma-R factor"
                     /protein_id="WP_073889370.1"
                     /transl_table=11
                     /translation="MSCGEPHETDCSEVLDHLYEFLDSEMPDVDRDKFQHHFEECSPCL
                     EKYGLEQAVKKLVKRCCGHDDVPSDLRAKVMGRIDLIRSGQTVPEHDVTATAQES"
     gene            5254..6585
                     /locus_tag="AMK32_RS06440"
                     /old_locus_tag="AMK32_06370"
     CDS             5254..6585
                     /EC_number="3.1.4.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674892.1"
                     /locus_tag="AMK32_RS06440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_06370"
                     /product="HD-GYP domain-containing protein"
                     /protein_id="WP_073889371.1"
                     /transl_table=11
                     /translation="MEAVPARARAYVACVALLAVVCLLPLPRTHAPWWPIGLLAALYAA
                     CEHPLGRRFGGTFYPVLLAGAFLLPPPAAALVPVPAALFARGEHRPAPLRRVWRAAQPS
                     LAVWGAAHVHWALGGRDAVVDRDFPYALLPAGAAVLAFCLILTVLDGGILALTVGVPAP
                     PGRGSAPARRAWRGLLARSLAPVAVHGLAGLMMAVLWRSPYGPAAALLVLLPMCVSWWV
                     FAQYHRERAAHQATIRALVQAVDIKDGYTRGHSERVGQASVLIARELGMDDERVEVLRF
                     AGILHDVGKLGVPTRLLRKDGPLTPEERRIIELHPEYGHEMVRGISFLGEARAAILHHH
                     ERLDGSGYPYGLAGTRIPECARVVAVADAFDAMTSTRSYSRARPVPAAVAELERCAGSH
                     FDPRMVAALVRALRRHGWHPAVTADEPAHDRAPRQRPAGTGTPR"
     gene            6582..7877
                     /locus_tag="AMK32_RS06445"
                     /old_locus_tag="AMK32_06375"
     CDS             6582..7877
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674893.1"
                     /locus_tag="AMK32_RS06445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_06375"
                     /product="metal-dependent phosphohydrolase"
                     /protein_id="WP_073889373.1"
                     /transl_table=11
                     /translation="MTAPLRLVHGAAALVAAGCLALTLASGLREGGVALAFGVLIAVGE
                     LTRWGAAPGRQAAPLGAAGSLSYALLGADAGRPTQHGAAQVVTVVLTAALLGAVPHIWS
                     GRTPTRDHLARRVLTVGFAAVCFQPLYNRGVFDSWDGPAYALLLVALLSLSALCDAVLA
                     AALAHFRTRWPFGPLLREELHGLLGIGSAVCATGAVMALGVAVAGLWALPVFCLPLLLT
                     QLSVRRHAAVRATYRQTIASLARATEIAGYTPAGHAHRVAALSLAVGRDLGLTGPELTV
                     LEYAALMHDIGQLSLVDPVPAGATADLPDEEQRRIALLGGAVVRQTGVDAAVAVVVERQ
                     ADPCREQPVAARIVRAVNAYEEKTRGTGPEGPLRALEELRLGTAGDYAPEIVESLARVL
                     TQPRGRGESVPTGGGGRRAALSDPVRGWVTHG"
     gene            7978..8985
                     /locus_tag="AMK32_RS06450"
                     /old_locus_tag="AMK32_06380"
     CDS             7978..8985
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889310.1"
                     /locus_tag="AMK32_RS06450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_06380"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_073889374.1"
                     /transl_table=11
                     /translation="MRIFGKGRHRPSASWRQATDRAFTLIGDGRYEDAGELLTRAADLE
                     PWLAESWFNLALLHKFRHDWEQARAAGLRAVALLDREAGAPDWWNVGIAATALQDWPLA
                     RRAWQAYGLKVPGGSSRPKGGPGAPVSGEPVGMELGSAAVRLSPEGEAEVVWGRRLDPA
                     RMEVLSIPLPSSGRRWGEVVLHDGVPHGERTTSTGHSYPVFDEIELWAPSPVPTWVVLL
                     EAATEADRDALEQLAADAGFAAEDWSSSVRLLCRMCSESRMPSDEGEGVHLDPHDHSEP
                     GHPGPLGHRTDGQLWVPERECGVAAPASLVRGLLDGWVADSPDSRDWRDLEEVC"
     gene            9059..9709
                     /gene="def"
                     /locus_tag="AMK32_RS06455"
                     /old_locus_tag="AMK32_06385"
     CDS             9059..9709
                     /EC_number="3.5.1.88"
                     /GO_function="GO:0042586 - peptide deformylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="def"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1275: peptide deformylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004983603.1"
                     /locus_tag="AMK32_RS06455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_06385"
                     /product="peptide deformylase"
                     /protein_id="WP_073889376.1"
                     /transl_table=11
                     /translation="MAQQDTDQQHAGVLPVDDEGYVVDTEDCEERETAWRERGTSRPIT
                     VVGNPVLHKECKDVTEFGEELQQLVADMFASQRTAEGVGLAANQIGVDLKVFVYDCPDD
                     EGERHVGVVCNPKLVELPAEQRRLDDSNEGCLSVPTAYAPLARPDYAEVTGQDEKGNPI
                     KVRGTGYFARCLQHETDHLYGYLYIDRLSKRDRKDALRQMAENEPRYPVVAND"
     gene            10001..11086
                     /gene="cyc1"
                     /locus_tag="AMK32_RS06460"
                     /old_locus_tag="AMK32_06390"
     CDS             10001..11086
                     /EC_number="4.2.3.37"
                     /GO_function="GO:0052680 - epi-isozizaene synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cyc1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003992851.1"
                     /locus_tag="AMK32_RS06460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_06390"
                     /product="epi-isozizaene synthase"
                     /protein_id="WP_107423600.1"
                     /sec_met_domain="T1TS (E-value: 5e-66, bitscore: 220.6,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQAFPHSTTATPTAVVVPPSLALPVIESAFPRRLHPYWPRLQEKT
                     RHWLLEKRLMPADKVHEYADGLCYTDLMAGYYTGAPDEVLQAIADYSAWFFVWDDRHDR
                     HVVHQRAGEWRRLRYRLHAALDAPRHHLHHPDPLVAGFADSVLRLYGFLPRSWNQRFAR
                     HFHAVIEAYDREFRNRTEGYVPGVEEYLALRRHTFAHWIWTDLLEPSAGCELPDAVRKN
                     PAYRRAALLSQEFAAWYNDLCSLPKEIAGDEVHNLGISLITHEGLTLEEAVDEVRRRVE
                     ECIEEFIVAEREAIRLADEIDDGTVSGKELSAAVRACVGNMRDWFSSVYWFHHESGRYM
                     VDSWDDRSTPPYVTNEAAGEK"
     gene            11083..12453
                     /locus_tag="AMK32_RS06465"
                     /old_locus_tag="AMK32_06395"
     CDS             11083..12453
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674897.1"
                     /locus_tag="AMK32_RS06465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_06395"
                     /product="cytochrome P450"
                     /protein_id="WP_073889379.1"
                     /sec_met_domain="p450 (E-value: 3e-65, bitscore: 217.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVESVKPVAPEAAELREPPLAGGAVPGLGHGLKLVRDPLAFMSG
                     LGEHGDVVRLRLGPKTVYAVTTPALTGALALSPDFKIDGPLWESLEGLLGKEGVATANG
                     PRHRRQRRTIQPAFRLDAIPDYGPVMEEEAHALTVRWRPGETIDCTSESFRVAVRIAAR
                     CLLRGEYMDERAERLSNDLATVFRGMYRRMVVPLGPLYRLPFPANREFNRALADLHLLV
                     DEIVAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETVASTIMWL
                     LQVLAEHPEHAEKVRTEVESVTGGRPVGFEHVRSLTHTNNVVVEAMRLRPAVWILTRRA
                     VTDTALGGYRIPAGADIVYSPYAIQRDARSYEGHLDFDPDRWRPERAKDVPKYAMSPFS
                     VGNRKCPSDHFSMTQLSLITAAVSAKYRFEQAGGSDDTTRVGITLRPHDLRLRAMPW"
     gene            complement(12476..13441)
                     /locus_tag="AMK32_RS06470"
                     /old_locus_tag="AMK32_06400"
     CDS             complement(12476..13441)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018544423.1"
                     /locus_tag="AMK32_RS06470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_06400"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_073889381.1"
                     /transl_table=11
                     /translation="MLKNVAAVLLDGVHPFELGVVCEVFGIDRSDEGLPVYDFAVVSAE
                     GPTLSTHVGGLSVSTPYGLERLEEADLIAVPAGADYVVRDYPPALLDALVRAVERGTRV
                     LSVCSGVFVLGAAGLLDGRRCSVHWRQAGELALRNPRAVIEPDVLYVDEDPVITSAGTA
                     AGIDACLHLVRKDQGPEVANKIARRMVVPPHRDGGQAQYIERPLPRTSCDTVGEVLVWM
                     EEHLDQEVTVEQLAARAHMSPRTFARRFQQETGTTPYRWILRQRVLLAQELLEGSDETM
                     DAIAWRTGFGTAAALRHQFVRAIGTTPNAYRRAFRGPQAA"
     gene            13535..13765
                     /locus_tag="AMK32_RS06475"
                     /old_locus_tag="AMK32_06405"
     CDS             13535..13765
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973747.1"
                     /locus_tag="AMK32_RS06475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_06405"
                     /product="hypothetical protein"
                     /protein_id="WP_073890416.1"
                     /transl_table=11
                     /translation="MNGNQIEGLIGMTATLGILLLLVLPSVLGIVRDRRIDRQLREAER
                     NGLRPAAASPQPPAPRRVTKSRRHHGATRAA"
     misc_feature    13551..13566
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.2"
                     /tool="antismash"
     gene            complement(13776..14789)
                     /locus_tag="AMK32_RS06480"
                     /old_locus_tag="AMK32_06410"
     CDS             complement(13776..14789)
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0009263 - deoxyribonucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674901.1"
                     /locus_tag="AMK32_RS06480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_06410"
                     /product="ribonucleotide-diphosphate reductase subunit
                     beta"
                     /protein_id="WP_073889382.1"
                     /transl_table=11
                     /translation="MSTRNQNLLDPGFELTLRPMRYPDFYERYRDAIKNTWTVEEVDLH
                     SDVADLAKLSPEEQHLIGRLVAFFATGDSIVANNLVLTLYKHINSPEARLYLSRQLFEE
                     AVHVQFYLTLLDTYLPDPEDRAAAFAAVENIPSIREKAGFCFKWINEVEKLDRLESKAD
                     RRRFLLNLICFAACIEGLFFYGAFAYVYWFRSRGLLHGLATGTNWVFRDETMHMSFAFE
                     VVDTVRKEEPDLFDDELQQQVVDMLREAVEAELQFARDLCGDGLPGMNTDSMRQYLECV
                     ADQRLTRLGFAPVYGSENPFSFMELQGVQELTNFFERRPSAYQVAVEGTVDFDEDF"
     gene            complement(14789..17158)
                     /locus_tag="AMK32_RS06485"
                     /old_locus_tag="AMK32_06415"
     CDS             complement(14789..17158)
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0009265 - 2'-deoxyribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006378224.1"
                     /locus_tag="AMK32_RS06485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_06415"
                     /product="ribonucleoside-diphosphate reductase subunit
                     alpha"
                     /protein_id="WP_073889384.1"
                     /transl_table=11
                     /translation="MTIAPADPASVSELKTDGPGAALLRTLTELTADLPDADPGRVAAA
                     ALRGRSARADEAELRELATEAAAGLISEDPAYSRLAARLLTLAIREEAASQGVTSFTES
                     VAVGHREGLIADRTAEFVRVHAERLDALVDRAADDRFGYFGLRTLHSRYLLRHPFTRKV
                     VETPQHFMLRVAAGLAEDDTVRSVDEVAALYGLMSRLDYLPSSPTLFNSGTRHPQMSSC
                     YLLDSPLDELDSIYDRYHQVARLSKHAGGIGLSYSRIRSRGSLIRGTNGHSNGIVPFLK
                     TLDASVAAVNQGGRRKGAAAVYLETWHSDIEEFLELRDNTGEDARRTHNLNLAHWIPDE
                     FMRRVNADEQWSLFSPADVPDLVDLWGAEFDAAYRAAEAAGLARKTIPARDLYGRMMRT
                     LAQTGNGWMTFKDAANRTANQTAEPGHVVHSSNLCTEILEVTDDGETAVCNLGSVNLGA
                     FVADGGIDWERLDETVRTAVTFLDRVVDINFYPTEQAGRSNARWRPVGLGAMGLQDVFF
                     KLRLPFDSPEAKALSTRIAERIMLAAYEASADLAERNGPLPAWEKTRTARGVLHPDHYG
                     VEPAWPERWAALRERIASVGMRNSLLLAIAPTATIASIAGVYECIEPQVSNLFKRETLS
                     GEFLQVNSYLVRDLKDLGVWDARTREALRESNGSVQDFAWIPADVRQLYRTAWEIPQRG
                     LIDMAAARTPYLDQAQSLNLFLETPTIGKLSSMYAYAWKSGLKTTYYLRSRPATRIARA
                     AQAQAQPQASIPVQQAADPDAVACSLENPESCEACQ"
     regulatory      complement(17282..17419)
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    complement(17403..17417)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 24.21"
                     /tool="antismash"
     misc_feature    complement(17434..17448)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: strong, score: 25.12"
                     /tool="antismash"
     gene            complement(17588..19216)
                     /locus_tag="AMK32_RS06490"
                     /old_locus_tag="AMK32_06420"
     CDS             complement(17588..19216)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674905.1"
                     /locus_tag="AMK32_RS06490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_06420"
                     /product="sodium:solute symporter family protein"
                     /protein_id="WP_073889385.1"
                     /transl_table=11
                     /translation="MKDGVNGVALGVFIFFFLAVTVMGFLAARWRRAENEHSLDEWGLG
                     GRSFGTWVTWFLLGGDLYTAYTFVAVPAAIYAAGASGFFAVPYTILVYPLIFTFLPRLW
                     SVSHKHGYVTTSDFVRGRFGSKGLSLAVALTGILATMPYIALQLVGIQAVLDVMGVGGG
                     ENTNWFVKDLPLLIAFGVLAAYTYSSGLRAPALIAFVKDALIYIVIAVAIIYIPIKLGG
                     FDDVFAKAGDAFSQVNPATGKPRGALVPPEAGQWTYATLALGSALALFMYPHSITATLS
                     SRSREVIRRNTTILPLYSLMLGLLALLGFMAIAAGVKVTNGQLAIPQLFEDMFPDWFAG
                     VAFAAIGIGALVPAAIMSIAAANLFTRNIYKDFIKPDATPRQEAQVSKIVSLLVKVGAL
                     VFVLTMDKTVAINFQLLGGIWILQTFPALVGGLFTRWFHRWALLAGWAVGMVYGTVAAY
                     GVASPTQKHFGGSAKEIPGIGEIGYIGLTAFVLNVVVTVVLTFVLKAVKAPEGLDQTRP
                     EDYTADAGDPGVQVELPPATAGTGH"
     gene            complement(19213..19476)
                     /locus_tag="AMK32_RS06495"
                     /old_locus_tag="AMK32_06425"
     CDS             complement(19213..19476)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004925869.1"
                     /locus_tag="AMK32_RS06495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_06425"
                     /product="DUF3311 domain-containing protein"
                     /protein_id="WP_198960316.1"
                     /transl_table=11
                     /translation="MSETPQVRPPVVTPVRVVIGLCLVAPFVAMLWLGSYARTDPTFIG
                     IPFFYWYQMLWVLISTALTMTAYKLWQHDQRSRNGAKGGAAQ"
     gene            complement(19615..20379)
                     /locus_tag="AMK32_RS06500"
                     /old_locus_tag="AMK32_06430"
     CDS             complement(19615..20379)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973740.1"
                     /locus_tag="AMK32_RS06500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK32_06430"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_073889388.1"
                     /transl_table=11
                     /translation="MSTDVSSAENEAGTTVRTARVPKYYRLKKHLLDMTETQAPGTPVP
                     PERTLAAEFDTSRTTVRQALQELVVEGRLERIQGKGTFVAKPKVSQALQLTSYTEDMRA
                     QGLEPTSQLLDIGYITADDRLADLLDITAGGRVLRIERLRMANAEPMAIETTHLSAKRF
                     PALRRSLVKYTSLYTALAEVYDVHLAEAEETIETSLATPREAGLLGTDVGLPMLMLSRH
                     SLDREGKPVEWVRSVYRGDRYKFVARLKRPVD"
     misc_feature    20516..20531
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 21.49"
                     /tool="antismash"
     misc_feature    20621..20635
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.74"
                     /tool="antismash"
ORIGIN
        1 cgagggccac ccggtcgccg accacggccg ccttgcggcc cagctcgcgc gccttcatcg
       61 ccatcacgat ccggtcctcg accaggcagg tcagccgccc ccggtcgacg gtgaggacca
      121 tgccctcggc cgcgtcctcg tgcttgggcc ggatgttcgt ccgcggccgg ttgcccttgc
      181 ggttgggacg gctgcggatg tcgtcctcgt cggtgtgctt gccgtagcgg cgcatggcgt
      241 gtccctactg cccgagcatc ccggtccaca gctcggggaa gtccggcagc gtcttggccg
      301 tggtcgccac gttctcgatc cgcacgccct cgacggccag gccgatgatc gcaccggcgg
      361 tggccatgcg gtggtcctcg taggtgtgga aggtgccgcc gtgcagggtg cgcgggcgga
      421 tgtgcaggcc gtcggccgtc tccgtgacgt cgccgccgag ttcgttgatc tccttggtga
      481 gcgcggccag ccggtccgtc tcgtgcagcc gcaggtgggc cacgccccgc agggtggagg
      541 gagagtcggc gagcgcggcg accgccgcga tgcccggggt cagctcgccg acgtcgctca
      601 ggtcgacgtc gatgccgtga acagcacccg aaccggtgaa cacgagcccg aactcggtca
      661 gttcgcagga gccgcccatc tcggtgaaga tctcccgcag ccggtcaccc ggctgggtgg
      721 tgcgggccgg ccagtccggg atcagcacct tgccgcccgt gatcagggcc gccgcgagga
      781 acggctgcgc gttggacagg tccggctcga tcgtcaggtc ccggccgagc agggcgcccg
      841 gcgtcacccg ccacacgttg ggctcgccgc ccgactccgg ggtgtccact tgggcgccga
      901 ccgcgcgcag catgtccacc gtcatccgga tgtgcggcat ggacggcagc gcggtgccgg
      961 tgtgccggac ctcgacgccc tggttgaagc gcggaccgga cagcagcagt gccgagacga
     1021 actgggagga cgaggaggcg tcgatcgaca ccggcccgcc gtccagggcc ccgccgccgt
     1081 ggacggtcag cggcagcgcg ccccggccgt cgtcgtcgat ccgggcaccg agatgacgca
     1141 gcgcgtcgat caccccgtgc agggggcgct cgtacgaccg cgggtcgccg tcgaagcgga
     1201 tagggccgtc ggccagcgcg gccaccgggg gcaggaagcg catcaccgtg ccggcgttgc
     1261 cgacgtcgac ggtggccggg ccccgcaggc ccgtgggcag cacccgccag gcctcgccgg
     1321 cgccgccgcc cgaggagctg gaggacaccg tctcctcgat ctccacgccc atcgcgcgca
     1381 gcgccccggc catcagcagg gtgtcgcgcg agcgcagcgg ccgccgcagc cagccgggct
     1441 cggaggccag ggcggcgagg acgagggcgc ggttggtgac cgacttggac cccggcacgt
     1501 ggaccgtggc gtcgacggct ctgctcgcgt gcggggcggg ccagagtgcg gtggatgcgg
     1561 tgttcggggc catggggcca ctttataagg aggctccggg gtcaaccttc cagcagccag
     1621 cgcccgccac cgatgagcga gcacagggac accgcgtgga acaggaacag ccacaggccc
     1681 gccggcacgt gcgtcagccg ggacagctgg tccgcgtccg agtcccccgc ccctccacgg
     1741 gaccgcttgg cctggagctc gaacggcggc cgcaccccgc cgaacagcag gaaccacacg
     1801 accgcgtacg cgaaggccgc ctgcacctgc gggcccgtca gccaggacac cagcaggaag
     1861 gcgccgcccg tgaggacgac ggtcaggacg ccgtacgcgt tgcggatcat caccagcatc
     1921 accaccagca gcgcggtcgc cgcccacagc agcagcgtga tgcggccggc ggccagcagg
     1981 gcggctccgc ccaggcccag cagcgagggc gccgtgtagc cggcggcggc cgtcaggatc
     2041 atgcccaggc cgtacggctt gccgcggctg accgtgagtc cgctggtgtc ggagtgcagg
     2101 cggatgccgg tgagctgccg gccggtgagc agggcgacca gaccgtggcc gccctcgtgg
     2161 gcgatggtga tcgcgttgcg ggatatccgc cacagcgtgc cggggacgac cacggcgagc
     2221 gcggcggcca gcgtggccag caccacccac aggtcggggt cggactgggt gccggtgagc
     2281 cggtcccaga cgtcgggcag cgcggtcgcg gcgaggctgt ccatggggcg gcgttgctcc
     2341 tgtcgtcgtc gtcaacaggt gtcggcgcgg ggcgccgtcg ctgaggaacg gtggtcggtg
     2401 gacgggtggg cctggcagtg tggcacgtat gtgcggacgg tatgcatcga gtcgtgggcc
     2461 cgaggatctc gcgggagtct tcgagatcga gaagtgggag ccggaggaga ccctggaacc
     2521 ggactacaac gtggcgccga ccaaggaggt ctacgccgtt ctcgaccgtc cggtgaaaga
     2581 cgcggactcc ccgcgtccgg ttcgccagct gcgcaagctg aagtggggcc tcgtgccctc
     2641 ctgggccaag acgcccgagg gcggcgcccg gatgatcaac gcccgcgcgg agaccgtgca
     2701 cgagaagccc tcctaccgcc gggccttcgc cacccgccgc tgcatcctgc ccgccgacgg
     2761 ctacttcgag tgggtcaccg gcaagcagga gcgcgatctg gaggaggagg gccggaagaa
     2821 gcgaccgcgc aagcagccct acttcgtgct gcccgccgac ggctcggtct tcgccatggc
     2881 cgggctgtac gagttctggc gcgaccggac cctgcccgac gaccacccgc aggcctggtg
     2941 ggtcacctgc tcggtgatca ccacggaggc ggagcggacc ccgctggccg tcgcccccgc
     3001 cgagggcccg cgctccctca ccgagatcca cccccggatg ccgctgatgc tgaccccgga
     3061 ccgctgggac gcctggctcg accccgcccg caccgacccc gaggacctgc gcgggctgct
     3121 ggctccgccg ccggccgggc tgatgcgcgc ctacccggtc tccacggccg tcagcaacgt
     3181 ccgcaacaac ggcccggagc tgctgaagga gctggagggc ccggaggagg gcacactctt
     3241 ctgacgtgag taccgagtcc gacacgacga ccgagaccgt cgccacgcag gccggggacg
     3301 cccggatcac ctggcaccgg gcgaagaggg cgcggctggt gctggccgtg agccacgggg
     3361 ccggcggcgg catcgaggcg cgggacctgc gggccctcgc ccgggtgctg cccgggcacg
     3421 gcgtgagcgt ggccctcgtc gagcagccct ggcgggtggc ggggaagaag ctcgcgcccg
     3481 cgccgaagac cctggacgcc ggctggcgcg gcctgtggcc cgcgctcgtc ggacccggcc
     3541 tgcccgtggt ctcgggcggg cgcagcgccg gcgcccgggt cgcctgccgc accgccggcg
     3601 agctcggcgc gcacgccgtg ctcgcgctga gcttcccgct gcacccgccg ggccggccgg
     3661 agaggtcccg cgcggcggaa ctgctgggca cgggggtgcc cacgctggtc gtccagggcg
     3721 gcaacgatcc gttcggaagg ccggccgagt tcccggcggg tgacttcgca ctcgtcgagg
     3781 tgccgcacgg cgaccacggg ttcgcggtcc ccaagcgcgc ggagaccacc caggaacggg
     3841 ccctggagat catcacggag agtgtcgtgg agtgggccgc gtcactcggg tgacccccgg
     3901 gaatgctgcg cgacgcatcg ctgttgtggc ggacagaagt gctgaggcct cggcaccgac
     3961 gtcgtgggaa aggaagtccg ccgcatgggt tcgaccatct gcccgagccg cagcagccgt
     4021 actgacctgg actggacggt gctgcacgcg gccaaggcca cccctattcg aggggcggcg
     4081 ggcccgggtg gtgttctatc ctccgaaacg agtaggaccg gtttcggtcc tgcccgggat
     4141 cttgaggagg tgggtccggt caccggtacc gacgcaggga ccgacaacgg tcaggcggag
     4201 ctgcccgagg gccagggcgt gagcgcggag gagtcctccg agtccaccgc ggagcgcagt
     4261 gcgcgcttcg agcgggacgc gctcgaattc ctcgaccaga tgtactcggc cgcgctgcgc
     4321 atgacgcgca atccggccga cgccgaggac ctggtgcagg agacgtacgc caaggcctac
     4381 gcgtccttcc accagttccg cgagggcacc aacctcaagg cgtggctgta ccggatcctg
     4441 accaacacgt tcatcaactc ctaccgcaag aagcagcgtg agccccagcg ctccgccgcg
     4501 gaggagatcg aggactggca gctcgcccgt gccgagtcgc acatgtcgac cggtctgcgc
     4561 tccgccgagt cgcaggcgct cgaccacctg cccgactcgg acgtgaagga agcgctgcag
     4621 gcgatccccg aggagttccg catcgccgtc tatctcgcgg acgtcgaggg gtttgcctac
     4681 aaggagatcg cggacatcat ggggacaccc atcggtacgg tgatgtcccg gctgcaccgg
     4741 ggccgccgtc agctgcgcgg catgctggag gactacgccc gtgagcgcgg gctggtgccc
     4801 gccggcgccg gggagtcgaa cgaagcgaaa ggctcgggct catgagctgc ggagagccgc
     4861 acgagacgga ctgcagtgag gtcctggacc atctgtacga gttcctcgac agtgagatgc
     4921 cggacgtcga ccgcgacaag ttccagcacc acttcgagga atgctcgccg tgcctggaga
     4981 agtacggcct ggagcaggcc gtgaagaagc tcgtcaagcg gtgctgcggc catgacgacg
     5041 tgccctccga cctgcgcgcc aaggtcatgg gacggatcga cctgatccgc tccggacaga
     5101 ccgtgccgga gcacgacgtc accgccaccg cccaggagag ctgaccgccg ggtcatcacc
     5161 cgaacgtgct aatcctcagg tcataggccc cgcctccctc ccggcccgcc ctaggctccg
     5221 agcctggacg ggcacggtcg gggaaggggc gcgatggagg cggtaccggc gagggctcgc
     5281 gcctatgtgg cctgcgtcgc cctgctggcc gtggtctgcc tcctgccgct gccgcgcacc
     5341 cacgccccct ggtggccgat cggcctgctc gcggcgctct acgcggcctg cgagcacccc
     5401 ctgggccgcc gtttcggcgg caccttctac ccggtcctgc tggccggagc gtttctgctg
     5461 cccccaccgg ccgccgcgct cgtcccggtg cccgcggcgc tgttcgcgcg cggggagcac
     5521 cggccggcgc cgctgcggcg cgtctggcgc gccgcacagc cgtcactggc cgtgtggggc
     5581 gccgcccacg tccactgggc gctcggcggc cgggacgccg tcgtcgaccg cgacttcccc
     5641 tacgcgctgc tgcccgccgg cgcggccgtc ctcgcgttct gcctgatcct caccgtcctc
     5701 gacggcggca tcctcgccct caccgtgggc gtgcccgcgc cccccgggcg ggggagcgcg
     5761 cccgcgcgcc gggcctggcg cgggctgctc gcccgctcgc tcgcgccggt cgccgtgcac
     5821 ggactcgccg ggctgatgat ggccgtcctg tggcgcagcc cctacggccc ggccgccgcg
     5881 ctgctcgtgc tgctgccgat gtgcgtctcc tggtgggtgt tcgcccagta ccaccgtgag
     5941 cgcgccgcgc accaggccac catccgcgcc ctggtgcagg ccgtcgacat caaggacggc
     6001 tacacacgcg gccacagcga acgcgtcgga caggcctccg tgctgatcgc ccgcgaactc
     6061 ggcatggacg acgaacgcgt cgaggtgctg cgcttcgccg gcatcctgca cgacgtcggc
     6121 aaactgggcg tgcccacccg gctgctgcgc aaggacggcc cgctgacccc cgaggaacgc
     6181 cggatcatcg agctgcaccc cgagtacggc cacgagatgg tgcgcgggat ctccttcctc
     6241 ggcgaggccc gcgccgcgat cctgcaccac cacgagcgcc tcgacggcag cggctacccg
     6301 tacggcctcg ccggcacccg gatccccgag tgcgcccgcg tcgtcgccgt cgcggacgcc
     6361 ttcgacgcga tgacctccac ccggtcctac agccgggcgc ggcccgtccc cgccgcggtg
     6421 gccgagctgg agcgctgcgc cggctcccac ttcgaccccc gcatggtcgc cgcgctcgtg
     6481 cgcgccctgc gccgccacgg ctggcatccc gcggtcaccg ccgacgagcc cgcccacgac
     6541 agggcacccc ggcagcggcc ggccggcacc gggacgcccc gatgacggcc ccgctgcggc
     6601 tcgtccacgg cgccgccgcc ctcgtcgcgg ccggctgcct ggccctcacc ctggcgagcg
     6661 gcctccggga agggggcgtc gcgctcgcct tcggcgtgct catcgccgtc ggcgagctga
     6721 cccgctgggg cgccgccccc ggccggcagg ccgcgcccct cggcgccgcc ggatcgctgt
     6781 cgtacgccct gctgggcgcc gacgccgggc ggcccacgca gcacggcgcg gcccaggtcg
     6841 tcaccgtcgt cctcaccgcc gccctgctcg gcgccgtccc gcacatctgg tccggccgca
     6901 cccccacccg cgatcacctg gcccgccgcg tcctcaccgt cggcttcgcc gccgtctgct
     6961 tccagcccct ctacaaccgg ggcgttttcg actcctggga cggccccgcc tacgccctgc
     7021 tcctggtcgc cctgctcagc ctcagcgcgc tctgcgacgc cgtgctggcc gcagccctgg
     7081 cccacttccg cacccgctgg ccgttcggcc cgctgctgcg cgaggagctg cacgggctgc
     7141 tcggcatcgg ctccgccgtc tgcgcgaccg gcgcggtgat ggcgctcggg gtcgccgtcg
     7201 cgggcctgtg ggcgctgccc gtcttctgcc ttcccctgct cctcacccag ctctccgtgc
     7261 gccggcacgc ggccgtccgc gccacctacc ggcagaccat cgcctccctc gcccgcgcca
     7321 cggagatcgc cgggtacacc cccgccggtc acgcccaccg ggtcgccgcg ctcagcctcg
     7381 ccgtcggccg ggacctcggc ctgaccggcc ccgaactgac cgtgctggag tacgcggccc
     7441 tcatgcacga catcggccag ctcagcctgg tcgacccggt cccggccggt gccaccgcgg
     7501 acctgcccga cgaggagcag cggcggatcg ccctgctcgg cggtgccgtc gtccggcaga
     7561 ccggcgtgga cgcggccgtc gcggtcgtcg tcgagcggca ggccgacccc tgccgtgagc
     7621 agcccgtcgc cgcgcggatc gtccgggccg tgaacgcgta cgaggagaag acccggggta
     7681 ccggccccga gggaccgctg cgtgcgctgg aggaactgcg tctcggcacc gccggggact
     7741 acgctccgga gatcgtggag tcgctggcac gggtcctcac ccagccgcgg ggacgcggcg
     7801 agagcgtgcc gaccgggggc ggcgggagac gcgcggcact gtctgacccc gtccgcggct
     7861 gggtaaccca tgggtaatga gcgcctttcg caccgcacgt ggttggatgc gagggagagg
     7921 gtgtccgggg gcacaagcca gcccactgag cggaactgga actggcaggc gggaatcgtg
     7981 aggatcttcg gcaagggacg gcaccggccc tccgcctcct ggcggcaggc caccgaccgc
     8041 gcgttcaccc tgatcggcga cggccggtac gaggacgcgg gcgagctgct gacacgcgcc
     8101 gccgacctgg agccgtggct cgcggagtcc tggttcaacc tcgccctgct gcacaagttc
     8161 cggcacgact gggagcaggc ccgggccgcc ggtctgcggg cggtcgccct gctggaccgg
     8221 gaggccggcg cccccgactg gtggaacgtc ggcatcgccg ccaccgccct gcaggactgg
     8281 ccgctggccc ggcgcgcctg gcaggcctac gggctgaagg tgcccggcgg ctcctcgcgg
     8341 ccgaagggcg gtcccggcgc ccccgtctcc ggtgagccgg tgggcatgga gctgggcagc
     8401 gcggccgtac ggctctcccc ggagggcgag gccgaggtcg tgtggggccg caggctggac
     8461 ccggcgcgga tggaggtgct gtccatcccg cttccgtcct ccggacgccg ttggggcgag
     8521 gtcgtgctgc acgacggcgt cccgcacggc gagcgcacga cgtccaccgg gcacagctac
     8581 ccggtcttcg acgagatcga gctgtgggcg ccgtcccccg tccccacctg ggtggtcctg
     8641 ctggaggcgg ccacggaggc ggaccgggac gcgctggagc agctggcggc cgacgccggg
     8701 ttcgccgccg aggactggtc ctcgtcggta cggctgctgt gccggatgtg ctcggagtcg
     8761 cggatgccgt cggacgaggg cgaaggggtg cacctcgacc cgcacgacca cagtgagccg
     8821 ggccatcccg ggccgctggg gcaccggacg gacggacagc tgtgggtccc ggagcgggag
     8881 tgcggggtcg ccgcgccggc ctcgctggtc cggggtctgc tggacgggtg ggtcgccgac
     8941 agcccggact cgcgggactg gcgggatctc gaagaggttt gctgagccgt ccgtgaccgg
     9001 ccgcctttag gctgtactcg cagaaatttc caggcttgca ggaaggcata cgtcggtcat
     9061 ggcgcagcag gacaccgatc agcagcacgc gggcgtgctc cccgtcgacg acgagggcta
     9121 cgtcgtggac acggaggact gcgaggagcg cgagacggcc tggcgggagc gcgggacctc
     9181 gcgcccgatc acggtcgtcg gcaacccggt gctgcacaag gagtgcaagg acgtcaccga
     9241 gttcggcgag gagctgcagc agctggtagc ggacatgttc gcgagccagc gcaccgccga
     9301 gggcgtgggc ctggccgcga accagatcgg ggtcgacctg aaggtcttcg tgtacgactg
     9361 ccccgacgac gagggcgagc ggcacgtcgg cgtggtgtgc aacccgaagc tcgtggagct
     9421 gcccgccgag cagcgccggc tggacgacag caacgagggc tgcctgtcgg taccgaccgc
     9481 gtacgcgccg ctcgcgcgcc ccgactacgc cgaggtgacc gggcaggacg agaagggcaa
     9541 cccgatcaag gtccggggca ccggctactt cgcacgctgt ttgcagcacg agaccgacca
     9601 cctctacggc tacctctaca tcgaccggct gtccaagcgg gaccgcaagg acgcgctgcg
     9661 gcagatggcc gagaacgagc cacgctaccc cgtggtcgcc aacgactagt cgccgcacgg
     9721 cagtaggggc gcccggccgg gatcactccc gggcgggcgc cccttcgcat gggtgcggtt
     9781 cgctcgtccg tgcgtcgtac atccggtcgc ttccgccctc cggcgatccc caatcggtca
     9841 cgcaagggga gattctcggc accttggggt agtgagtgaa gcaaatccgt tcccacgacg
     9901 gtcagttgtg gtgctgaatg taagtgcggg atacgcaacg gcgcacgccc ggcacgacgg
     9961 gaggggcgtg agctcctggc ggctgagagg ggtttgttct gtgcaagctt tcccacacag
    10021 caccacagcg acaccgacgg cggtggtggt cccaccctca ctggcactcc cggtgatcga
    10081 gtccgccttt ccccggcgac tgcacccgta ttggccgcga ctacaggaga agacgcggca
    10141 ctggctgctg gaaaaacggc tcatgccggc ggacaaggtg cacgaatatg ccgacggact
    10201 ttgctacacc gacctcatgg cgggttacta caccggcgcc cccgacgagg tcctgcaggc
    10261 catagccgac tacagcgcct ggttcttcgt ctgggacgac cggcacgacc gccacgtggt
    10321 gcaccagcgg gccggcgagt ggcggcggct gcgctaccgc ctgcacgcgg cgctcgacgc
    10381 gcccaggcac cacctgcacc atccggaccc gctggtcgcg gggttcgccg acagcgtgct
    10441 gcggctgtac gggttcctgc cccgcagctg gaaccagcgg ttcgcccggc acttccacgc
    10501 ggtgatcgag gcgtacgacc gcgagttccg caaccgcacc gagggatatg tgcccggcgt
    10561 cgaggaatac ctcgccctgc gccgccacac cttcgcgcac tggatatgga cggacctgct
    10621 ggagccgagc gccgggtgcg aactgccgga cgcggtacgg aagaatcccg cgtaccgcag
    10681 ggccgcgctg ctgagtcagg aattcgccgc ctggtacaac gacctttgct cactgcccaa
    10741 ggaaatagcg ggcgacgagg tccacaatct cggaatcagc ctcatcacgc acgaggggct
    10801 gactctcgaa gaagccgtgg acgaagtgag gcggcgcgtc gaggaatgca tcgaggaatt
    10861 catcgtggcc gaacgggaag ccatccggct cgccgacgaa atcgacgacg gcacggtgag
    10921 cggcaaggaa ttgagcgccg ccgtccgcgc ctgcgtcggc aatatgcggg actggttcag
    10981 ctccgtctac tggttccacc acgagtccgg ccggtacatg gtcgacagct gggacgaccg
    11041 gtccacgccc ccgtacgtca ccaacgaagc ggcaggtgag aaatgaccgt cgagtctgtg
    11101 aagcccgtgg cccccgaggc ggcggagctg cgggagcccc cgctggccgg gggcgcggtg
    11161 ccgggcctcg ggcacggcct gaagctggtg cgcgacccgc tcgcgttcat gtccgggctg
    11221 ggcgagcacg gcgatgtcgt gcgcctgagg ctcggcccca agacggtgta cgccgtcacc
    11281 acgccggcgc tcaccggcgc actggcgctg agccccgact tcaagatcga cggacccctg
    11341 tgggagtccc tcgaaggact gctcggcaag gagggcgtgg ccaccgccaa cggcccccgg
    11401 caccggcgtc agcggcgcac catccagccc gcgttccggc tcgacgcgat cccggactac
    11461 ggcccggtga tggaggagga ggcgcacgcg ctgaccgtgc gctggcggcc cggcgagacc
    11521 atcgactgca cctcggagtc cttccgggtc gccgtccgta tcgccgcccg ctgtctgctg
    11581 cgcggcgagt acatggacga gcgcgccgag cggctcagca acgacctcgc caccgtcttc
    11641 cgcgggatgt accggaggat ggtggtcccg ctcggaccgc tgtaccggct gccgttcccg
    11701 gccaaccgcg aattcaaccg ggcgctggcc gatttgcatc tgctggtcga cgagatcgtc
    11761 gccgagcgga gggcatctgg tcaaaagccg gacgatttgc tgacggcatt gctggaggcg
    11821 aaggacgaca atggcgaccc catcggggaa caggagatcc acgaccaggt cgtcgcgata
    11881 ctcacccccg gcagcgaaac agtcgcgtcc acgatcatgt ggctgctcca ggtcctcgcg
    11941 gaacatccgg aacacgccga gaaggtacgg accgaggtcg aatccgtgac cggtggccgg
    12001 cccgtcggat tcgagcacgt ccgctcactg acgcacacga acaatgtcgt agtcgaggcc
    12061 atgcggctca ggcccgccgt atggatattg acgcggcgcg cggtgaccga caccgcgctc
    12121 ggcggctatc gcattccggc cggggccgac atcgtctaca gcccctacgc gatccagcgc
    12181 gacgcccgct cctacgaggg ccacctcgac ttcgaccccg accgctggcg gcccgagcgg
    12241 gccaaggacg tgccgaagta cgcgatgagc ccgttcagcg tgggcaaccg caagtgcccg
    12301 agcgaccact tctccatgac ccagctgagc ctgatcaccg cggcggtctc ggcgaagtac
    12361 cgcttcgagc aggccggcgg gtcggacgac accacccgcg tgggcatcac gctccgtccg
    12421 cacgacctgc gcctgcgggc gatgccctgg taggccgact gataccggcg cgcgctcagg
    12481 cggcctgagg gccccggaac gcgcgccggt aggcgttcgg ggtcgtcccg atcgcccgga
    12541 cgaactggtg ccgcagcgcg gccgccgtgc cgaacccggt gcgccaggcg atcgcgtcca
    12601 tcgtctcgtc cgagccctcc agcaactcct gtgccagcag cacccgttgg cgaaggatcc
    12661 accggtaggg cgtggtcccc gtctcctgct ggaagcggcg cgcgaaggtg cgcggcgaca
    12721 tgtgggcgcg ggcggcgagc tgttccacgg tcacctcctg gtcgaggtgc tcctccatcc
    12781 acaccaggac ctccccgacg gtgtcgcacg aggtccgcgg cagcggccgc tcgatgtact
    12841 gcgcctgccc gccgtcccgg tgcggtggca ccaccatccg gcgggcgatc ttgttggcga
    12901 cctccgggcc ctggtccttg cgcaccaggt gcagacaggc gtcgatcccg gcggcggtgc
    12961 cggcggaggt gatgacgggg tcctcgtcga cgtagaggac gtccggctcg atgaccgccc
    13021 gcggattgcg cagcgccagc tccccggcct gccgccagtg cacgctgcac cggcgcccgt
    13081 cgagcagccc ggccgcgccg agcacgaaga cgcccgagca cacgctgagc acccgggtgc
    13141 cccgctccac ggcccgcacc agggcgtcga gcagcgcggg cggatagtcc cggacgacgt
    13201 agtcggcccc ggcgggcacg gcgatcaggt cggcctcctc cagccgctcc aggccgtacg
    13261 gcgtcgacac ggagagcccg ccgacatgcg tgctcagcgt cggcccctcc gccgagacca
    13321 ccgcgaagtc gtacaccggc agcccctcgt cgctgcggtc gatgccgaac acctcgcaca
    13381 cgacacccag ctcgaagggg tgcaccccgt ccagcagtac tgcggccacg ttcttcagca
    13441 tgctgccagt gtgcctcgtc ggtggcagta attcgagggt ctgcggcagt cctgccactc
    13501 acggtaagga gcattcggcg cgacagtggt gtccatgaac ggaaaccaga tcgaaggcct
    13561 gatcggaatg accgccaccc tcgggatcct gctcctgctg gtcctcccgt ccgtgctcgg
    13621 catcgtgcgc gaccggcgca tcgaccggca gctcagggag gccgagcgga acgggctgcg
    13681 gccggcggcc gcgtccccgc agccaccggc cccccggagg gtcaccaagt cccgccgtca
    13741 ccacggcgcc acccgcgccg cctgagggcg gccggtcaga agtcctcgtc gaagtcgacc
    13801 gtgccctcca cggcgacctg gtacgcggac ggacggcgct cgaagaagtt cgtcagctcc
    13861 tggacgccct gcagctccat gaaggagaag gggttctccg agccgtacac cggggcgaag
    13921 ccgagacgcg tcagacgctg gtcggcgacg cactccaggt actggcgcat ggagtcggtg
    13981 ttcatgccgg gcaggccgtc accgcacagg tcgcgcgcga actgcagctc cgcctcgacg
    14041 gcctcccgca gcatgtcgac gacctgctgc tggagttcgt cgtcgaacag gtccggctcc
    14101 tccttgcgga cggtgtcgac cacctcgaag gcgaaggaca tgtgcatcgt ctcgtcgcgg
    14161 aacacccagt tggtgcccgt ggcgagaccg tgcagcagac cccggctgcg gaaccagtag
    14221 acgtacgcga aggcgccgta gaagaacagc ccctcgatgc acgcggcgaa gcagatcagg
    14281 ttgagcagga agcggcgtcg gtccgccttc gactcgaggc ggtccagctt ctccacctcg
    14341 ttgatccact tgaagcagaa cccggccttc tcgcggatcg aggggatgtt ctcgacggcg
    14401 gcgaaggcgg cggcccggtc ctccgggtcg ggaaggtagg tgtcgagcag cgtcaggtag
    14461 aactggacgt gcacggcctc ctcgaacagc tggcgcgaca ggtacaggcg cgcctccggg
    14521 gagttgatgt gcttgtacag cgtcagcacc aggttgttcg cgacgatcga gtcgcccgtc
    14581 gcgaagaacg cgaccagccg gccgatcagg tgctgctcct ccggggacag cttcgcgagg
    14641 tcggccacgt ccgagtgaag gtcgacctcc tccacggtcc acgtgttctt gatggcgtcc
    14701 cggtagcgct cgtagaagtc cgggtagcgc atgggacgca gggtcagctc gaagcccggg
    14761 tcgaggaggt tctggttacg ggtggacatc actggcaggc ctcgcaggac tcggggttct
    14821 caagggagca ggcgaccgcg tcggggtcgg cggcctgctg gacggggatg gacgcctggg
    14881 gctgcgcctg ggcctgggcg gcccgggcga tccgcgtcgc cgggcgggag cgcaggtagt
    14941 acgtcgtctt caggcccgac ttccaggcgt acgcgtacat cgaggagagc ttgccgatgg
    15001 tcggcgtctc caggaacagg ttcagggact gcgcctggtc caggtacggg gtacgcgccg
    15061 cggccatgtc gatgaggccg cgctgcggga tctcccaggc ggtgcggtac agctgccgga
    15121 cgtccgccgg gatccaggcg aagtcctgca ccgagccgtt ggactcgcgc agcgcctcgc
    15181 gggtgcgcgc gtcccacacc ccgaggtcct tcaggtcccg taccaggtag gagttgacct
    15241 ggaggaactc acccgacagc gtctcgcgct tgaacaggtt ggagacctgc ggctcgatgc
    15301 actcgtagac gcccgcgatg gaggcgatgg tggcggtcgg ggcgatggcg aggagcagcg
    15361 agttgcgcat gccgaccgag gcgatccgct cgcgcagcgc cgcccagcgc tccggccagg
    15421 ccggctccac accgtagtgg tcggggtgca gcacaccgcg ggcggtacgg gtcttctccc
    15481 aggccggcag cgggccgttg cgctcggcga ggtcggcgga cgcctcgtag gcggccagca
    15541 tgatgcgctc ggcgatccgc gtcgacaggg ccttcgcctc gggcgagtcg aagggcagcc
    15601 gcagcttgaa gaagacgtcc tgcagaccca tcgcgccgag gcccaccggc cgccacctgg
    15661 cgttggagcg gcccgcctgc tctgtcgggt agaagttgat gtccacgacg cggtcgagga
    15721 aggtgacggc ggtgcggacc gtctcgtcca gccgctccca gtcgatgccg ccgtcggcga
    15781 cgaaggcgcc caggttgacc gagcccaggt tgcagaccgc ggtctcgccg tcgtccgtga
    15841 cctcaaggat ctccgtgcag aggttggagg agtggacgac gtggcccggc tcggccgtct
    15901 ggttggcggt gcggttggcc gcgtccttga aggtcatcca gccgttgccg gtctgcgcca
    15961 gcgtgcgcat catgcggccg tacaggtcac gggccgggat ggtcttccgg gccagcccgg
    16021 cggcctcggc cgcgcggtac gcggcgtcga actccgcgcc ccacaggtcc accagatcgg
    16081 gcacgtccgc cggggagaac agcgaccact gctcgtcggc gttgacgcgg cgcatgaact
    16141 cgtccgggat ccagtgcgcc aggttcaggt tgtgcgtacg gcgggcgtcc tcaccggtgt
    16201 tgtcccgcag ctccaggaac tcctcgatgt cggagtgcca ggtctccagg tacaccgcgg
    16261 ccgcgccctt gcgccggccg ccctggttca ccgcggccac cgaggcgtcc agggtcttca
    16321 ggaacgggac gatgccgttg gagtgcccgt tggtgccgcg gatcagcgaa ccgcggctgc
    16381 ggatccggga gtacgacaga ccgatgccgc ccgcgtgctt ggagagccgc gcgacctggt
    16441 ggtaccggtc gtagatggag tccagctcgt ccagcgggga gtccagcagg tagcaggacg
    16501 acatctgcgg gtgccgcgta ccggagttga acagggtggg ggaggacggc aggtagtcga
    16561 ggcggctcat gagcccgtag agcgccgcga cctcgtccac cgagcggacg gtgtcgtcct
    16621 cggccaggcc ggcggcgacc cgcagcatga agtgctgggg cgtctcgacg accttgcggg
    16681 tgaaggggtg ccgcagcagg tagcggctgt gcagggtgcg caggccgaag tagccgaagc
    16741 ggtcgtcggc ggcccggtcg accagcgcgt ccagccgctc ggcgtgcacc cggacgaact
    16801 cggcggtccg gtccgcgatg agcccctcgc ggtgccccac ggccacggac tcggtgaacg
    16861 aggtgacgcc ctgcgaggcg gcctcctcgc ggatggcgag ggtcagcaga cgggcggcca
    16921 gccgggagta ggcggggtcc tcggagatca ggccggcggc cgcctccgtg gccagctcgc
    16981 gcaactccgc ctcgtcggcc cgagcggacc ggccgcgcag cgcggcggcg gcgacccggc
    17041 cggggtcggc gtcggggagg tcggcggtca gctcggtcag ggtccgcagc agcgcggcac
    17101 cgggaccgtc ggtcttcagc tcgctgactg aagccgggtc ggctggcgcg atggtcacgt
    17161 ggggctctcc ctcgctcggc acagggcctg gcggagggca gggggcagcc acgagcgcgc
    17221 acggcgtcgc gtccaccggc ccactccgcg aggcccggac gtctgtgagc acccggaccg
    17281 gacggccggg cgcgctggcg gcaggtcctc ggactgaaca ggcgtgcgga gacacgcaag
    17341 tacaccgttg cgggacagtt ccggattcgc accggattcc cctgcggcga cagcgagcac
    17401 gagcatacat cttgtgctcg cccggcacgc cacccccaga tgttgtgtcg ccgtcggttt
    17461 cagagcgtca actggtaggt gagaagagtg atgtcgccgg cctccggccc gggcggcggc
    17521 ggtgcgccgg gcggaaacgg cgacgggccg ccggatctcc tccggcggcc cgtcgcgcgg
    17581 ctgcggctca gtgaccggtg cccgccgtcg ccggcggcag ctccacctgg acgcccgggt
    17641 cgccggcgtc cgcggtgtag tcctccggcc gggtctggtc gaggccctcg ggggccttca
    17701 cggccttcag gacgaaggtc aggaccacgg tgacgacgac gttcaggacg aaagcggtga
    17761 ggccgatgta cccgatctcg ccgatacccg ggatctcctt cgcggagccg ccgaagtgct
    17821 tctgcgtcgg cgaggccacc ccgtacgcgg cgaccgtgcc gtacaccatg ccgaccgccc
    17881 agccggccag cagcgcccag cggtggaacc agcgggtgaa caggccgccc accagggccg
    17941 ggaaggtctg caggatccag atgccgccca gcagctggaa gttgatggcg accgtcttgt
    18001 ccatggtgag gacgaagacc agcgcgccca ccttcaccag cagcgacacg atcttggaga
    18061 cctgggcctc ctgcctgggc gtggcgtccg gcttgatgaa gtccttgtag atgttgcggg
    18121 tgaagaggtt ggccgccgcg atggacatga tggccgccgg cacgagcgcg ccgatgccga
    18181 tcgccgcgaa ggccacgccc gcgaaccagt ccgggaacat gtcctcgaac agctgcggga
    18241 tcgccaactg cccgttggtc accttcaccc cggccgcgat cgccatgaag cccagcagcg
    18301 ccagcaggcc cagcatgagc gagtacagcg gcaggatggt ggtgttccgg cggatcacct
    18361 cacggctcct ggacgacagg gtcgcggtga tcgagtgcgg gtacatgaac agcgcgaggg
    18421 ccgagccgag cgccagcgtg gcgtaggtcc actggcccgc ctcgggcggg acgagggcgc
    18481 cgcgcggttt gccggtggcc gggttgacct ggctgaacgc gtcgcccgcc ttggcgaaga
    18541 cgtcgtcgaa gccgcccagc ttgatcggga tgtagatgat cgccaccgcg atgacgatgt
    18601 agatcagcgc gtccttgacg aacgcgatca gcgcgggcgc gcgcaggccg gaggagtacg
    18661 tgtaggccgc gagcacaccg aaggcgatga gcagcgggag gtccttcacg aaccagttgg
    18721 tgttctcgcc gccgccgacg cccatcacgt cgagcaccgc ctggatgccc acgagctgca
    18781 gcgcgatgta cggcatcgtc gccaggatgc cggtgagcgc caccgccagc gacaggccct
    18841 tcgagccgaa ccggccgcgc acgaagtccg aggtggtcac gtagccgtgc ttgtgcgaga
    18901 cggaccacag gcggggcagg aaggtgaaga tcagcgggta caccaggatc gtgtacggca
    18961 ccgcgaagaa gccggacgcg cccgccgcgt agatggccgc cgggacggcg acgaaggtgt
    19021 aggccgtgta caggtcaccg cccagcagga accaggtgac ccaggtgccg aacgaccggc
    19081 cgcccaggcc ccattcgtcc agggagtgct cgttctcggc ccggcgccag cgcgcggcca
    19141 ggaagcccat gaccgtgacg gccaggaaga agaagatgaa gacgccgagc gcgacgccgt
    19201 tgaccccgtc cttcactgcg cggcaccccc cttcgcaccg ttgcgggaac gctggtcgtg
    19261 ctgccacagc ttgtacgcgg tcatcgtgag cgcggtggag atcagcaccc agagcatctg
    19321 gtaccagtag aagaacggga tcccgatgaa cgtggggtcc gtcctggcgt acgagccgag
    19381 ccacagcatc gcgacgaagg gcgccacgag acacaggccg atgacgaccc ggaccggtgt
    19441 caccaccgga ggtctcactt gaggtgtttc ggacatgcca cggctcccgt cccctcgctg
    19501 atcacgcgtg taatgcgcag gcaatctagg tgacgggatc agtgcacggg aagacctcgt
    19561 ccggatatcg gtatgccgat ttcggggtgg cggtgtgaag aggggccgcc ggggtcagtc
    19621 gacgggccgc ttcagccgcg cgacgaactt gtaccggtcg ccccggtaga ccgaccgcac
    19681 ccactccacg ggcttgccct cgcggtccag cgagtgccgg gagagcatca gcatcggcag
    19741 gcccacgtcc gtgccgagca ggcccgcctc acggggcgtg gccagggagg tctcgatggt
    19801 ctcctcggcc tcggcgaggt ggacgtcgta gacctcggcg agcgccgtgt acagcgacgt
    19861 gtacttcacc agcgagcggc gcagggccgg gaagcgcttg gcgctcaggt gcgtggtctc
    19921 gatcgccatc ggctcggcgt tggccatgcg cagccgctcg atgcgcagca cccgcccgcc
    19981 ggcggtgatg tcgagcaggt cggcgagccg gtcgtcggcc gtgatgtagc cgatgtccag
    20041 cagctgcgag gtcggctcca ggccctgggc gcgcatgtcc tcggtgtacg aggtgagctg
    20101 cagcgcctgg gagaccttgg gcttggcgac gaaggtgccc ttgccctgga tgcgctccag
    20161 ccgtccctcg acgacgagct cctgcagggc ctggcggacg gtggtgcggg aggtgtcgaa
    20221 ctcggcggcc agcgtgcgct cgggcggtac cggcgtgccc ggcgcctgcg tctccgtcat
    20281 gtcgagcagg tgcttcttca agcggtagta cttgggcacg cgcgcggtac ggacggtcgt
    20341 gccggcctcg ttctccgcac tgctgacgtc ggtgctcatg ctctgccttc ccggctccgg
    20401 atgccgaaag cgaccgacct cgcatcggcc acggctcaca tcgtggcacg gcttcgtgcg
    20461 ccaggagtcc accccgcacg ctccgtgatc tcctctgtat accggggccc ccgctgttgg
    20521 tctagtccat caggggcagt gcgtgcggcg gcatcccggc cgcgccgccg ccgctccggt
    20581 cagatcccct gccactccgg cttgtgcgcg taggtgtggc ggaagtagtc ggccagcttc
    20641 agcttgcccg cggccgcctc gtcgacgacg accgtggcgt gcgggtggag ctggagcgcg
    20701 gaggccgggc acaccgccgc gaccggtccc tcgacggtcg ccgcgacggc gtccgccttg
    20761 ccctcgccgg tcgccagcag caccaggtgc cgggcctcca ggatcgtgcc gatgccctgg
    20821 gtgatgacgt ggtgcgggac ctgctcgatg tcaccgtcga agaagcgcgc gttgtcgacg
    20881 cgggtctgct cggtcagcgt cttgatccgg gtgcgcgagg cgagcgagga gcacggctcg
    20941 ttgaacccga tgtgcccgtc ggtcccgatg ccgagcagct ggaggtcgac cccgccggcc
    21001 gcggcgagcg cccggtcgta cgcctcgcac gccgcctgca cgtccgcggc cgtgccgtcc
    21061 gggcccatga acgcgtccat gccgat
//
