LOCUS       NZ_LIVZ01000010        22484 bp    DNA     linear   CON 27-MAR-2024
DEFINITION  Streptomyces sp. TSRI0107 scaffold10, whole genome shotgun sequence.
ACCESSION   NZ_LIVZ01000010
VERSION     NZ_LIVZ01000010.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. TSRI0107
  ORGANISM  Streptomyces sp. TSRI0107
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 362821)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 362821)
  AUTHORS   Yan,X., Ge,H., Hindra,F., Yang,D., Huang,T., Crnovcic,I. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-AUG-2015) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2014
            Assembly Method                   :: CLC Genomics Workbench v. 7.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905845.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:50:25
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,745
            CDSs (total)                      :: 7,667
            Genes (coding)                    :: 7,467
            CDSs (with protein)               :: 7,467
            Genes (RNA)                       :: 78
            rRNAs                             :: 2, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 200
            CDSs (without protein)            :: 200
            Pseudo Genes (ambiguous residues) :: 0 of 200
            Pseudo Genes (frameshifted)       :: 85 of 200
            Pseudo Genes (incomplete)         :: 158 of 200
            Pseudo Genes (internal stop)      :: 13 of 200
            Pseudo Genes (multiple problems)  :: 51 of 200
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:19:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 253508
            Orig. end                         :: 275992
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LIVZ01000010.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22484
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(micKC and not PKS_KS)"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..22484
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="neighbouring"
                     /product="lanthipeptide-class-iii"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..22484
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12484](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12484
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    3..17
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 20.21"
                     /tool="antismash"
     misc_feature    461..477
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 21.74"
                     /tool="antismash"
     misc_feature    complement(480..498)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 18.06"
                     /tool="antismash"
     gene            696..1655
                     /locus_tag="AMK31_RS27045"
                     /old_locus_tag="AMK31_26635"
     CDS             696..1655
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013002398.1"
                     /locus_tag="AMK31_RS27045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_26635"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_073943259.1"
                     /transl_table=11
                     /translation="MTAYSVLVPFLPRRPEQLLPYAALVEWTAARRLWQGQAMLIEPFQ
                     GFASAAGAGFRVPTGVGVTLMALRHPYEAAHQVRSLALATGEPVVAGFGPGGRQFQESV
                     LSRPYASPLTASREYLTIVRGLLEQGAVDFDGEYFSCHGAMPPAIHPRVDLGLGVLRAG
                     MARLAGEVADVGITWLTPAGYLRDVIFPALREGASRAGRPTPRLTAMVPLALAGPDRDP
                     EKLVLASNAAHMQAPHYIDMLKKAGIELAGDASVADAKTMLHGKAFLYGGLEEIRAELD
                     AYREIGVDEVILNLTGVYNLYGPQAAMADLRKLLAAAA"
     gene            1673..2728
                     /gene="mpaB"
                     /locus_tag="AMK31_RS40735"
                     /old_locus_tag="AMK31_26640"
     CDS             1673..2728
                     /codon_start=1
                     /gene="mpaB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013002399.1"
                     /locus_tag="AMK31_RS40735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_26640"
                     /product="daptide biosynthesis RiPP recognition protein"
                     /protein_id="WP_073943260.1"
                     /transl_table=11
                     /translation="MAATRISSVKKHLSSWGTGRVQPLETPAGKGSLTVVLEDAEHLDA
                     LLASDLVGGSTLVLSPGESREDVAGVAGVVGYEGSLAEPGGDLSVDDEFFLQTQDYASA
                     GYMSVIGATLVRVVEQADLDAFLDDADRARADGTFPTHVTSPAVQLADLAALGAGPAED
                     GPRTRLYVDADGTAAVSPWGAPLGTIADGLDALDARWRRLSEDAVHPCAVALGRAVPAA
                     AGQAAAAGRPWLGRYLAAVDALRELHARGIADIRVSGFGGRLSPALAGLPDGDDTGVPL
                     LLWTDDAAYVHLAGDRRTFRVDHAAGALLEALLVCGSVDAAAGYADRDGLLRAERLLTA
                     AGVRLRAVTPA"
     gene            2725..3528
                     /gene="mpaM"
                     /locus_tag="AMK31_RS27055"
                     /old_locus_tag="AMK31_26645"
     CDS             2725..3528
                     /codon_start=1
                     /gene="mpaM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010353340.1"
                     /locus_tag="AMK31_RS27055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_26645"
                     /product="daptide-type RiPP biosynthesis methyltransferase"
                     /protein_id="WP_079186941.1"
                     /transl_table=11
                     /translation="MTTTLEVPGRAGEFVRELGGRARLHDLYDDTGSGVYDDLCAADTS
                     ELREILHLVRRTKGPVLELAAGSGRLTFPLLATGREVTALELSPGMLRLLTDRLAEAPA
                     RLRERCLPVRADMSRFALGRRFGAIVLGTTSVSLLDEHGRAGLYRAVGEHLLPGGSFLV
                     SVIDPAPGEVADPETEFAVTGATGRRYRMVEHWPPAAATRTVTVLPADPPAEGPVDVCV
                     STVRVVSADLLAAELTGAGLVVRARHALPGGGPRHREVLLEVGTA"
     gene            3525..4787
                     /gene="mpaD"
                     /locus_tag="AMK31_RS27060"
                     /old_locus_tag="AMK31_26650"
     CDS             3525..4787
                     /NRPS_PKS="Domain: Aminotran_3 (22-351). E-value: 5.6e-65.
                     Score: 211.5. Matches aSDomain:
                     nrpspksdomains_AMK31_RS27060_Aminotran_3.1"
                     /codon_start=1
                     /gene="mpaD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005482729.1"
                     /locus_tag="AMK31_RS27060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_26650"
                     /product="daptide-type RiPP biosynthesis aminotransferase"
                     /protein_id="WP_073943261.1"
                     /sec_met_domain="Aminotran_3 (E-value: 3.7e-69, bitscore:
                     227.6, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNALWPSLLAPADHGRPDLCAVAASGVRLTFADGRTRLCGTSGL
                     WNTNLGYGNEAVAAAVHEALLKASYLSVFRYENDYARRAAEALVELCGAETYGRVLFST
                     SGGAANDLVMKLARHYQALRGETRRTLVVGLRGGYHGLTYGSLALTGEDLGQQLYGVDQ
                     RQIRHVTPNDLGELATLMDRQGARIAAVVVEPVLGSGAVPLTAEYVAELLRLRDEHGFL
                     LVADEVATGFGRTGTFLASQGWPAPPDLVIVSKGLTNGTCAAAAVVAARPVADAFDTAG
                     AVLTHAETQAGTPATCAAILATVEETRRLDAIAAGRRLAARLDTALDRLVAEEPAVTGT
                     TGTGLFRSVRLSGPDGTPLPAPRVPELVAAIREAGAVVHPGPSGIQLIPALTYSDAELD
                     ELMCRVADGIAAYVATAGAAV"
     aSDomain        3591..4577
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMK31_RS27060_Aminotran_3.1"
                     /evalue="5.60E-65"
                     /label="AMK31_RS27060_Aminotran_3.1"
                     /locus_tag="AMK31_RS27060"
                     /protein_end="351"
                     /protein_start="22"
                     /score="211.5"
                     /tool="antismash"
                     /translation="VAASGVRLTFADGRTRLCGTSGLWNTNLGYGNEAVAAAVHEALLK
                     ASYLSVFRYENDYARRAAEALVELCGAETYGRVLFSTSGGAANDLVMKLARHYQALRGE
                     TRRTLVVGLRGGYHGLTYGSLALTGEDLGQQLYGVDQRQIRHVTPNDLGELATLMDRQG
                     ARIAAVVVEPVLGSGAVPLTAEYVAELLRLRDEHGFLLVADEVATGFGRTGTFLASQGW
                     PAPPDLVIVSKGLTNGTCAAAAVVAARPVADAFDTAGAVLTHAETQAGTPATCAAILAT
                     VEETRRLDAIAAGRRLAARLDTALDRLVAEEPAVTGTTGTGLFRSVRL"
     gene            4784..5977
                     /gene="mpaC"
                     /locus_tag="AMK31_RS27065"
                     /old_locus_tag="AMK31_26655"
     CDS             4784..5977
                     /codon_start=1
                     /gene="mpaC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF041822.1"
                     /locus_tag="AMK31_RS27065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_26655"
                     /product="daptide-type RiPP biosynthesis dehydogenase"
                     /protein_id="WP_079186942.1"
                     /sec_met_domain="Fe-ADH (E-value: 1.2e-35, bitscore: 117.3,
                     seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLGWHCPTMLIAGHEGLSVWLAEQPDVRTVTVLADPAVAHGEIT
                     ALVRAQIAKAGRTDRVLTVAGTGDLASAVALADRLAGTDLVVGVGGGSLLDRAKLAALL
                     GDPAARARLAVAQRGGLTALPHDLRRTARLVAVPTTLGTGTELSPVACLARDGGKRLVL
                     GNALQPDVALLDPAATATLPRELVAEGVLEVLFRVAGLYVGDHRDLPTEDALAVAMAEA
                     AVRYGNAARDAYAAGRAPDAALRTEIAKLSGLSHQGWSVLGREPYCCRGWYVANELASV
                     CGVRKMTAVAALLPPLWRAVADGDARWGSARRLHALWERLRATDPRLPGDPADGIAALI
                     DGWGVGRRIVAPGVAEEVARRSVRAWGSGLPMLGAFRGADIARLVERTQTSGFPVTA"
     misc_feature    complement(6006..6022)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 15.0"
                     /tool="antismash"
     gene            6040..6216
                     /locus_tag="AMK31_RS40740"
     CDS             6040..6216
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF041808.1"
                     /locus_tag="AMK31_RS40740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="daptide-type RiPP"
                     /protein_id="WP_158074555.1"
                     /transl_table=11
                     /translation="MLHSVEVREQDEFALELGMQELEALEAPGWWSVTGYISGAGVGGA
                     VTYSVVATAISAT"
     misc_feature    6071..6086
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.27"
                     /tool="antismash"
     gene            6265..6444
                     /locus_tag="AMK31_RS27070"
                     /old_locus_tag="AMK31_26660"
     CDS             6265..6444
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005482722.1"
                     /locus_tag="AMK31_RS27070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_26660"
                     /product="daptide-type RiPP"
                     /protein_id="WP_073943263.1"
                     /transl_table=11
                     /translation="MQDTKAPFSLDDMPALELGMQELEAMEAPGFWSNFKEGVSVSVAV
                     SAVYGGVASAISAT"
     misc_feature    6496..6510
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.03"
                     /tool="antismash"
     gene            6624..6821
                     /locus_tag="AMK31_RS27075"
                     /old_locus_tag="AMK31_26665"
     CDS             6624..6821
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK31_RS27075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AMK31_26665"
                     /product="hypothetical protein"
                     /protein_id="WP_073943264.1"
                     /transl_table=11
                     /translation="MSENESWRAANAKLALVIPVLVAGIAVSQVSLDGWAADGLTVFCA
                     AALIAVLLRIGLNARSGGGR"
     gene            6818..7564
                     /locus_tag="AMK31_RS27080"
                     /old_locus_tag="AMK31_26670"
     CDS             6818..7564
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003980797.1"
                     /locus_tag="AMK31_RS27080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_26670"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_073943265.1"
                     /transl_table=11
                     /translation="MTDTAVARFDGVTKRFGDTAAVEDVSFEVRPGRIVGLLGRNGAGK
                     TTSLRMLLGLTRPTSGRATVFGRPYAELPGAERRVGVSMDGIGTLPGVTGRRELSIWAR
                     MLELPASRVDEVLEQTGLTGAADKKIKGYSTGMRQRHAMAAALLADPELLVLDEPANGL
                     DPDGIRWLRTFLRSLADQGRTILLSSHLLAEVEQTVDDVVVLQRTLRYSGTLAELTEDG
                     KHALEDRFFELVGTGAGGGNGAVVHA"
     gene            7557..8300
                     /locus_tag="AMK31_RS27085"
                     /old_locus_tag="AMK31_26675"
     CDS             7557..8300
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013002406.1"
                     /locus_tag="AMK31_RS27085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_26675"
                     /product="ABC transporter permease"
                     /protein_id="WP_073943266.1"
                     /transl_table=11
                     /translation="MRNVIAAEWRKAWTGSAWWLLPLCGVFLSVLASSGYAAQAEEQLA
                     DRQTDLVAVTDEMVRSWFMLLLFSALFGAVLVTREFGSGAIHRSVLLGGTRDRLFAAKL
                     IVGTAMGVLYAALAAGLAAASPYVFLPGIGESPEWSGDTTLTLLGVFTVTVLGAPWGVL
                     LGWVLRNQVAAVGTLLVLTLLVDESLLRLVPDAGRFTMTIAMSSVYRDGKPELLSVPVA
                     LLVIGVWLALAGFVGRRLFTRRDLN"
     cand_cluster    7814..19067
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    7814..19067
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[12813:14067](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      12814..14067
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
     gene            8300..9970
                     /gene="mpaP"
                     /locus_tag="AMK31_RS27090"
                     /old_locus_tag="AMK31_26680"
     CDS             8300..9970
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="mpaP"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003980795.1"
                     /locus_tag="AMK31_RS27090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_26680"
                     /product="daptide biosynthesis intramembrane
                     metalloprotease"
                     /protein_id="WP_073943267.1"
                     /transl_table=11
                     /translation="MRALQLLERRRSPAPAPADHLTRPRLAPDVRVHAPLATGAPWVVQ
                     RGSQQYLRVGADLARLLQVLDGERGHAGLVAELGPPWTEQAVGRAVASLGEKGLLDDGS
                     RKRHSGTWFKFVPPLTFQLTLLKPERLLNALAPLVDRLANRAGAVVAAVLALGGLLALV
                     AQGPALAGALGEPLPLAVLLGVSLGSTVTTALHEIGHGAVLTYYGGRPSRMGVMLFYLT
                     PAFFCDVSDGWRLPHREQRVRVALAGIVTQAVVAGTAAFAALATGLAGGAPTLRAGLTV
                     FAVSTYVTGVLNLLPFVKLDGYLALMSHLDTSHLRDRAMTDARRLVARVLFGGRRYERE
                     LPALRWAPAFGLACMVFPLYLIGLALTLWLDILTGLGVIGASVVLAALAYLGYRAGKGA
                     SLLVREARKGGARIWRLLLAGAVAAAGLGAALAFVTVPYTITGGFVSEDGRTRLVLSDA
                     ADRAAVREGAAVTLQRRGLVLRTDLGTATVTGGAKPGTAPLSAFVPVREGDELPVPAYE
                     VPLAFDGGTDDHAGLARVDAGERPLGEWLYLSYVAPVWR"
     gene            10001..12484
                     /gene="lanKC"
                     /locus_tag="AMK31_RS27095"
                     /old_locus_tag="AMK31_26685"
     CDS             10001..12484
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003980794.1"
                     /locus_tag="AMK31_RS27095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_26685"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_073943268.1"
                     /sec_met_domain="micKC (E-value: 4.6e-198, bitscore: 654.3,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 2.9e-15, bitscore: 50.7,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="APH (E-value: 5.5e-07, bitscore: 24.1,
                     seeds: 156, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 6.4e-07, bitscore:
                     22.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDIVRHLHFCPPGTPFFDAPASAPDPADDFGPVRDALPAGWSRKV
                     GGEWVQWAPDGVEIPLQGWKIHASATPDSAPAILDTVVKYCVAERVMFKFIRSLPVLRR
                     RNGKYGDRSASGKFVTLYPADEARFEKILRELGGLLEGQPGPYILSDLRWGPGPLYVRY
                     GGFALRTARTDTGEQVYCVEDPDGRLVPDRRGPGFRPPEWVTLPDCLAESLAARNAGTL
                     KDFPYRVTQALHFSNGGGVYRGVDTRTGADVLLREARPLAGLDGDGRDAVARHEREHWA
                     LRRLDGLDCIPRLVDYRIGHEHYFLVREYVEGRSLSKETLRRNPLLLGETSAQARAEYA
                     AWALDVLEQIDRGVTAMHGRGVVFGDLHPGNVLVLDDGTVRFIDFETASAVDADAAQTM
                     AAVGFAAPEGVRGAAVDRYALGCLRLALFAPVAAVLPWGPEKVTEALELIRGRFPVPAD
                     FAEAVRRDLGLPETPGEPSPGVWHGDPAEWPRLRDALAEGIAGTATPDRTDRLFPGDAE
                     QFFAPEGGVGFAYGAAGVLWALAEAGVPVPEDHTDWLTKAALELNEPQPGFWTGLAGIA
                     YALDRLGRADTARRLVDRALDETVRPRRGGLLDGVSGLGLTALHFGDTHLEAAVRLAET
                     ITPTPDTGRPPGLLHGASGTALFLIRLYERTGDPALLDRAGTALRADLAALGWSSEEGR
                     FGAESVGRLPLISTGSGGTALVLQAWLRHREDPDFTAARDAVMALTEGHFAPQAGVFHG
                     RAGVLAVRLGLGAAGDPQGLLDPFGLHVVPHDGRPAFLGRENLRVSTDFATGGAGVLAV
                     LDAAVGGRVPRLPFL"
     gene            12814..14067
                     /locus_tag="AMK31_RS27100"
                     /old_locus_tag="AMK31_26690"
     CDS             12814..14067
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF014661.4"
                     /locus_tag="AMK31_RS27100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_26690"
                     /product="YcaO-like family protein"
                     /protein_id="WP_073943269.1"
                     /sec_met_domain="YcaO (E-value: 1.7e-41, bitscore: 137.3,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDVLPALEPSAGLVTLSRISPPAPPADLLWRCTVELARAEPDRA
                     GGVLSARLAGAHGHSSTDAMLRGVGEAVERYALHPDGPAPAGAVRATAAGLGSRAQRFH
                     GPDVALGAATDRELTWYPATRLRDGATVLVPSALVDYPLTGPDADGFDPSPSGAAAGEG
                     WTAAVRSALLETVERDAFQVAWERDLRPVRVADPGTDRTLTRLLRRAAQAGLEAVLAEV
                     PTGVPGVACAIGVVVDEAGPHPLATLGCKASDDPARRLLGALQEALQIRSAALVARERA
                     DRWPGGAVRDDDDRLRFLASPEGYARVRAWTDAFAQDGPGGPGDPAARRVSTDELVRAM
                     VTDGADPLIVDLTHRLPLGVRESGWAAVKAVPVGYQQLRIDDTRTDTWNRARLASAEAR
                     TGLTAGPAPTGVRPHPLP"
     gene            14076..15143
                     /locus_tag="AMK31_RS27105"
                     /old_locus_tag="AMK31_26695"
     CDS             14076..15143
                     /EC_number="2.7.7.24"
                     /GO_function="GO:0008879 - glucose-1-phosphate
                     thymidylyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0000271 - polysaccharide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019549711.1"
                     /locus_tag="AMK31_RS27105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_26695"
                     /product="glucose-1-phosphate thymidylyltransferase"
                     /protein_id="WP_073943270.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 3e-14, bitscore:
                     48.0, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKALVLAGGTGSRMRPLTHTAAKQLIPVGNKPILFYGLEALVAAG
                     VTEIGIVVGDTHREIREAVGDSGRFGARVTYLRQERPLGLAHAVLIARDFLADDDFVLY
                     LGDNFLVGGIDEVVADFRAARPDAGVLLTRVPDPSAFGVAELGPDGRLARLEEKPAEPR
                     SDLAVVGVYLFTPAIHEAVRAVEPSPRGELEITDALQWLIDQGHVVRPTLVKGYWKDTG
                     TAADLLAVNRTVLDGLTPEVRGSVDAGSVISGRVRVEPGARVVRSRVVGPAVIGAGAEV
                     VDSCVGPYTALAEGCRVVRSGVADSIVLSRAEIAGVGRVEASLVGRHASVHSTDHVSTA
                     HRLVLGDHSSVHIGH"
     gene            15257..16279
                     /gene="rfbB"
                     /locus_tag="AMK31_RS27110"
                     /old_locus_tag="AMK31_26700"
     CDS             15257..16279
                     /EC_number="4.2.1.46"
                     /GO_function="GO:0008460 - dTDP-glucose 4,6-dehydratase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009243 - O antigen biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0019305 - dTDP-rhamnose biosynthetic
                     process [Evidence IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (4-181). E-value: 7.4e-14.
                     Score: 43.4. Matches aSDomain:
                     nrpspksdomains_AMK31_RS27110_NAD_binding_4.1"
                     /codon_start=1
                     /gene="rfbB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016430996.1"
                     /locus_tag="AMK31_RS27110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_26700"
                     /product="dTDP-glucose 4,6-dehydratase"
                     /protein_id="WP_073943271.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.3e-20, bitscore:
                     67.2, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 1.1e-13,
                     bitscore: 45.3, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 4e-13, bitscore:
                     43.4, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRILVTGGAGFIGSHFVRLLLGPDPGSRPTAVTVLDALTYAGDLT
                     RLDAVAGDPRYDFVYGDVRDRPLVEELVGGHDAVVHLAAETHVDRSIGGAGEFVSSNVL
                     GTQVLLDAVLRHGRTLVHVSTDEVYGSIAEGSWTEDCPPAPRSPYAAAKASSDLLALAY
                     HHTHGLDVRVTRCSNNYGPYQHPEKLIPRFSTLLLDGGRVPLYGDGRNVRDWLHVEDHC
                     RALLRVLLAGRAGRVYNIGGGTELTNLRLTRLLLDAFGAGPERIERVPDRKGHDLRYSV
                     DSGRIRRELGWRPRHSFAEGLAATVDWYRDNRAWWERHLAERDPAAAPQPSSRTGSPSR
                     "
     aSDomain        15269..15799
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMK31_RS27110_NAD_binding_4.1"
                     /evalue="7.40E-14"
                     /label="AMK31_RS27110_NAD_binding_4.1"
                     /locus_tag="AMK31_RS27110"
                     /protein_end="181"
                     /protein_start="4"
                     /score="43.4"
                     /tool="antismash"
                     /translation="VTGGAGFIGSHFVRLLLGPDPGSRPTAVTVLDALTYAGDLTRLDA
                     VAGDPRYDFVYGDVRDRPLVEELVGGHDAVVHLAAETHVDRSIGGAGEFVSSNVLGTQV
                     LLDAVLRHGRTLVHVSTDEVYGSIAEGSWTEDCPPAPRSPYAAAKASSDLLALAYHHTH
                     GLDVRVTRCSNNYG"
     gene            complement(16243..17202)
                     /locus_tag="AMK31_RS27115"
                     /old_locus_tag="AMK31_26705"
     CDS             complement(16243..17202)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014048327.1"
                     /locus_tag="AMK31_RS27115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_26705"
                     /product="D-2-hydroxyacid dehydrogenase family protein"
                     /protein_id="WP_073943272.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 2.2e-55, bitscore:
                     181.1, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLRCALLDDFQNAGTSAADWSPVADRVDVVPFTEHFDGEDELAA
                     ALAGFDIVVTLRERVPFPASLLARLPRLRLIVATGMRNTVIDHAAARAHGVTVCGTESS
                     STPPVELTWALILGLARGLVQENTGLREGGPWQSTVGADLHGRVLGLLGLGKIGSRVAA
                     IGQAFGMDVVAWSRNLTDERAGEAGVRRAASKEELLARSDVVSVHLVLSDRTRGLLGAP
                     ELALMKPDAFLVNTSRAAIVDQDALLAALHEGRIAGAGVDVFDVEPLPAGHPMRTAPRL
                     LATPHLGYVTRANYARYYGQAVEDIRAYLDGEPVRLLG"
     misc_feature    complement(17380..17397)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.41"
                     /tool="antismash"
     gene            17552..20752
                     /locus_tag="AMK31_RS27120"
                     /old_locus_tag="AMK31_26710"
     CDS             17552..20752
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009298000.1"
                     /locus_tag="AMK31_RS27120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_26710"
                     /product="AfsR/SARP family transcriptional regulator"
                     /protein_id="WP_073943273.1"
                     /transl_table=11
                     /translation="MRQSVMRFGLLGPPVLYQPCAAQGPQGTFVRTIRSPKARALLAVL
                     LLEAGRVVPVGSLKDALWGGAPPASAHASLHNHVTRLRRLLDDPDRLRAVPPGYVLRVE
                     PFELDVHVFEHHATAARTAHAAHDWERVVREAGAALALWRGTPLCGLPPELGGYAFVQR
                     LEEARLLLLEWRYDAELAVGGDRLGELVPELAELAAEHPLREAYQRQLMLALHRTDRRA
                     EALAVHRDLRARLLEELGVEPGPAVREAHLEVLRALPRTEPAAEPAPSDTAAETDAEAA
                     LSAPRPAQLPPPPPHFTGRTAARDELCRALLEPGAVAVVSGMAGVGKSALALHAAHTLA
                     ERFPDGQLYINLHGATPGMTPLTAPQALAALLRDLGAEPRRIPEHPDAAAALLRSLLAP
                     TRTLLVLDDAAHAAQIRPLLPGGPGCAVIVTSRSPLTALDGARRFPLAPLTGEDSAALL
                     RAVSGRDGLDAAHPLVDLTGRLPLALRVVAARLAARTALTPDVLADQLAATGSRLHHLE
                     YDDLSVRSSLAVAHDALAASSREADRDAAHALRRIGALDLPAYGAPLLARLTGTDERRA
                     EAALDRLVDVALLEETAYGRYEPHDLVRDFARELAEKQTGTGASGTDVGGEHEGADSGE
                     TGAEPGEAAPVSEGEADAEARALPRTGAGTGGTPSAPGRADDPSTEASGAVETALHWYA
                     AVAERALTAIVEPGLDQDDRRRPTAAQPPEHAAHVAATTPFRSAKAAFAWGDLELPNIV
                     TLVERHAGDPAHDHRTAAYVSTLIRLLFPYVQRSGRVAEMEVLGGAALDAARRLGDPAA
                     EAYALGDLAGLHFLTGRQGDALALNDRALEIWRRLGVVSWIRRCLNNRGLLLEGLGRYA
                     ESEAALRQSLTYSRQLRDPHGEAVTYSHLGNLYEHTDPRAAIEQHRRSLSIGVSIGAVI
                     VQHSAHCNIGYAHLSLGEPAAAARHFEESLRILGCRGDWHGESQTRLGLVRALRQLGLT
                     DRAASECAELMRRADARADHYTGGLARHQNGLLLHARGLHERAYDEWRTALAALDGTDD
                     SAVTAELRALLAGADARR"
     gene            complement(20765..22450)
                     /locus_tag="AMK31_RS27125"
                     /old_locus_tag="AMK31_26715"
     CDS             complement(20765..22450)
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006261 - DNA-templated DNA replication
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020141026.1"
                     /locus_tag="AMK31_RS27125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_26715"
                     /product="bifunctional 3'-5' exonuclease/DNA polymerase"
                     /protein_id="WP_073943274.1"
                     /transl_table=11
                     /translation="MTDRWALAAAEGGGVELAPLGPDGLPSGPVLREADLARAVRERPE
                     VTRWVWRSTHEVYPRLLATGVRVERCYDIEDAETLLLGHEGRYGEPRSAAAALARLRGG
                     PVPPDPPQRAAEPGAQSPLFEPQDRPLPLADLLAVYAEQQRRHDRTAHPDRMRLLTAAE
                     SAGMLVAAEMNRAGLPWSTDVHRAVLHDLLGERYAGGGEPRRLAELADEVSAAFGRRVR
                     PDLPADVVKAFAQAGIKIRSTRRWELESVDHPAVKPLLEYKKLYRIWVAHGWSWLQDWV
                     RDGRFRPEFLAGGTVTGRWVTNGGGGLQIPKVIRRAVVADPGWRLVVADADQMEPRVLA
                     AISRDPGLMEVAGRESDLYQSVSDRAFSGDRAQAKLAVLGAVYGQTSGDGLKNLAALRR
                     RFPRAVAYVDDAARAGEEGRLVRTWLGRTCPPAARTGDDAAEEAGIPAPDEDGDDRQWV
                     PGYASTDARARGRFARNFVVQGSAADWALLLLAALRRACAGLAAELVFFQHDEVIVHCP
                     EEEAETVVAAIREASELAGRLTFGETPVRFPFTTAVVECYADAK"
ORIGIN
        1 ttggacgatc cgttctggca ggcccgccga ccggcccggg tggtgggcgt cgtcgaccgg
       61 gacgaccccg atcacggctt cgtctccgcc gtgcgggagg tgctgcacgg gcgcggctgg
      121 ctgtcgccgg agctggtgcc gtacgtcctg ggcggcggcg cgccgcgcgc tccgcggcag
      181 cggtcggccc aggtgctggg cgagggcggg ctcaccggcc gggagcggga tgtcgccctg
      241 ctggtcgcgg agggtctgtc gaatctcgag atagccgagg aactgaccgt cgaactcagc
      301 accgtgaagt tccatgtgtc gaacgtgctg cgcaagctgg gctgccggga ccggtcgcaa
      361 ctggtcgcgg tcattcacgc gggccggcac atggcggggc gcgcctagat tcgccgaagt
      421 cgaagccgaa gccgaaggcg ggcctgggaa ggaaatcacc cgtacataaa aggtgcgggg
      481 ccggaagtct gtccaggaat ccctttgtgg tgcggggaat ccccgtcctg cgacggggga
      541 gaagactctc ctcagggcgg gggttggaac ctggagggcc gggttaccgt cttccctgcc
      601 gggaggccgc cgagcgaaat ccattctgac tgaccatcgg taatggatgg gtagcctccg
      661 ggtaaagaca acggaatggc ttcacggggg atttgatgac cgcgtattcg gtgctcgtgc
      721 cgtttctgcc gcgcaggccg gaacagctgc tgccgtacgc ggcgctggtc gagtggacgg
      781 ccgcgcggcg gctctggcag ggccaggcca tgctgatcga gccgttccag ggcttcgcct
      841 cggcggccgg cgcgggcttc cgggtgccga ccggcgtggg cgtcaccctg atggcgctgc
      901 gccaccccta cgaggccgcg caccaggtgc gctcgctggc cctggccacc ggggagccgg
      961 tggtcgcggg gttcggaccg ggcggccggc agttccagga gagcgtcctg agcaggccgt
     1021 acgccagtcc gctgaccgct tcgcgggagt atctgaccat cgtgcggggc ctgctggagc
     1081 agggcgcggt cgacttcgac ggcgagtact tctcctgcca cggggcgatg ccgcccgcga
     1141 tccacccccg cgtcgacctc ggtctggggg tgctgcgggc gggcatggcc cggctcgcgg
     1201 gcgaggtcgc cgacgtcggc atcacctggc tgaccccggc cggctatctg cgggacgtga
     1261 tcttcccggc gctgcgcgag ggcgcctcgc gggccgggcg accgacgccg cggctgaccg
     1321 cgatggtgcc gctggcgctc gccggacccg accgggaccc ggagaaactg gtgctggcga
     1381 gcaatgcggc acatatgcag gcgccgcact acatcgacat gctgaaaaag gcgggaatcg
     1441 aactcgccgg agacgcctcg gtcgccgacg cgaaaaccat gctgcatgga aaggcatttc
     1501 tctacggcgg cctggaggag atccgggcgg aactcgacgc ctatcgggag atcggcgtcg
     1561 acgaggtgat cctcaatctg accggcgtgt acaacctgta cggcccgcag gcggccatgg
     1621 ccgatctcag gaaactgctg gccgcggccg cgtgacaagg gggagaacgc atatggctgc
     1681 cactcggata tcgagtgtga agaagcacct cagttcctgg ggaaccggtc gggtccagcc
     1741 gctggaaaca cccgccggga agggctcgct caccgtcgtc ctggaggacg cggagcatct
     1801 cgacgcgctt ctcgcctccg atctcgtcgg cggctccacc ctggtgctga gccccggtga
     1861 gtcccgcgag gacgtcgccg gcgtcgccgg tgtcgtcggc tacgagggct ccctggccga
     1921 gcccggcggc gacctctccg tcgacgacga gttcttcctc cagacccagg actacgccag
     1981 cgccggctac atgtcggtga tcggcgccac cctcgtccgg gtcgtggagc aggccgacct
     2041 cgacgccttc ctcgacgacg cggaccgcgc ccgcgccgac ggcaccttcc cgacccacgt
     2101 caccagcccc gccgtccagc tcgccgacct cgccgcgctc ggcgccggcc cggcggagga
     2161 cggcccgcgc acccggctct acgtggacgc ggacggcacg gccgccgtct ccccgtgggg
     2221 cgccccgctc ggcacgatcg ccgacggcct cgacgcgctg gacgcccggt ggcggcggct
     2281 cagcgaggac gccgtccacc cctgcgcggt cgccctcggc cgggccgtgc ccgcggcggc
     2341 gggccaggcc gcggccgccg gccggccctg gctgggccgc tacctcgcgg ccgtcgacgc
     2401 gctgcgcgaa ctgcacgcga ggggcatcgc cgacatccgc gtctccggct tcggcggccg
     2461 gctgtcgccc gccctggccg ggctgccgga cggcgacgac accggcgtac cgctgctgct
     2521 gtggaccgac gacgccgcgt acgtgcacct cgccggggac cgtcgcacct tccgcgtcga
     2581 ccacgcggcc ggcgcgctgc tcgaggcgct gctggtgtgc ggctccgtcg acgcggccgc
     2641 cgggtacgcc gaccgggacg ggctgctgcg cgccgagcgg ctgctgaccg ccgccggtgt
     2701 acggctccgg gcggtgaccc cggcgtgacg accaccctgg aggtgccggg ccgggcgggc
     2761 gagttcgtca gggaactcgg cggccgcgcc cgcctccacg acctgtacga cgacaccggc
     2821 tccggcgtct acgacgacct gtgcgccgcc gacacctccg aactgcggga gatcctgcac
     2881 ctggtccgcc gtaccaaggg cccggtgctg gaactggccg cgggatcagg ccggctgacg
     2941 ttcccgctgc tcgccaccgg ccgcgaggtc accgccctgg aactgtcccc gggcatgctg
     3001 cgcctgctca ccgaccgcct cgccgaggcg cccgcgcgac tgcgcgagcg gtgcctgccg
     3061 gtgcgggccg acatgagccg cttcgcgctc gggcggcggt tcggcgcgat cgtgctgggc
     3121 acgacgtcgg tgtcgctgct ggacgagcac gggcgggcgg gcctgtaccg ggcggtcggg
     3181 gagcatctgc tgcccggcgg ttccttcctg gtgtcggtga tcgacccggc tcccggggag
     3241 gtcgccgacc ccgagaccga gttcgccgtc accggcgcca ccggccgccg ctaccgcatg
     3301 gtcgagcact ggccgcccgc cgcggccacc cgcacggtca ccgtcctgcc cgccgacccg
     3361 cccgccgagg gccccgtcga cgtctgcgtc tccacggtcc gggtcgtctc cgccgacctg
     3421 ctggcggccg agctgaccgg cgccggactc gtcgtccgcg cccggcacgc cctgccgggc
     3481 gggggacccc ggcaccgcga ggtgctgctg gaggtgggca ccgcatgagc aacgccctgt
     3541 ggccgtcgct gctcgccccc gccgaccacg gccgtcccga cctgtgcgcg gtcgccgcct
     3601 ccggcgtccg gctgaccttc gccgacggcc gcacccggct gtgcggcacc agcggactgt
     3661 ggaacaccaa cctcggctac ggcaacgagg ccgtcgccgc cgccgtccac gaggcgctgc
     3721 tgaaggcctc gtacctgagc gtgttccggt acgagaacga ctacgcgcgc cgggccgccg
     3781 aggcactggt ggagctgtgc ggcgccgaga cgtacggcag ggtcctgttc tccacctcgg
     3841 gcggcgcggc gaacgacctc gtcatgaagc tggcccggca ctaccaggcg ctgcgcggcg
     3901 agacccgccg caccctggtg gtgggcctgc gcggcggcta ccacggtctg acctacggct
     3961 ctctcgccct gaccggcgag gacctgggcc agcagctgta cggcgtggac cagcggcaga
     4021 tccgtcacgt cacaccgaac gacctcggcg aactggccac cctgatggac cgccagggcg
     4081 cgcggatcgc ggccgtggtg gtggagccgg tgctgggctc cggcgccgta ccgctcaccg
     4141 ccgagtacgt ggccgagctg ctgcggctgc gggacgagca cggattcctg ctggtcgccg
     4201 acgaggtcgc gaccgggttc gggcggaccg gcacgttcct cgcctcgcag ggctggcccg
     4261 cgccgcccga cctggtgatc gtctccaagg ggctcaccaa cggcacctgc gcggcggccg
     4321 ccgtggtggc cgcgcggccg gtggcggacg ccttcgacac cgccggggcc gtgctcaccc
     4381 acgccgagac ccaggccggc acgcccgcca cgtgcgcggc gatcctcgcc accgtcgagg
     4441 agacacgcag gctggacgcg atcgcggcgg gccgccggct cgccgcccgg ctcgacaccg
     4501 cgctggaccg gctggtcgcc gaggagcccg cggtcaccgg caccaccggc accggcctgt
     4561 tccggtcggt ccggctgtcc gggccggacg gcacgccgct gcccgcgccg cgggtgccgg
     4621 agctggtcgc ggcgatccgg gaggccggcg cggtcgtcca cccgggcccg tccggcatcc
     4681 agctcatccc cgccctgacc tactcggacg cggagctgga cgagctgatg tgccgggtcg
     4741 ccgacggcat cgccgcgtac gtggcgaccg cgggggccgc cgtatgagcc tcggctggca
     4801 ctgcccgacc atgctgatcg ccggccacga gggactgtcc gtgtggctgg ccgagcagcc
     4861 ggacgtccgc acggtgaccg tcctcgcgga cccggcggtc gcgcacggcg agatcaccgc
     4921 gctggtccgc gcccagatcg ccaaggccgg ccgcaccgac cgggtgctga cggtcgccgg
     4981 caccggcgac ctggcgtccg ccgtcgcgct cgccgaccgg ctggccggca ccgacctggt
     5041 ggtcggcgtg ggcgggggct cgctgctcga ccgggccaag ctggccgcgc tgctgggcga
     5101 cccggcggcc cgcgcccgcc tggcggtggc ccagcgcggc gggctgaccg cgctgccgca
     5161 cgatctgcgg cgcacggcac ggctggtggc ggtgcccacg accctgggca ccggcaccga
     5221 gctgagcccg gtcgcctgcc tggcgcggga cggcggcaag cggctggtgc tgggcaacgc
     5281 cctccagccg gacgtggccc tgctggaccc ggcggcgacc gcgacgctgc cgcgcgaact
     5341 cgtcgccgag ggcgtgctgg aggtgctgtt ccgggtcgcc gggctgtatg tcggcgacca
     5401 ccgggacctg ccgacggagg acgcgctggc ggtggccatg gcggaggcgg cggtgcggta
     5461 cggcaacgcg gcgcgcgacg cgtacgcggc gggccgggcg ccggacgccg cgctgcgcac
     5521 cgagatcgcc aagctgagcg ggctcagcca ccagggctgg agcgtgctgg ggcgggagcc
     5581 gtactgctgc cgcggctggt acgtggccaa cgagctcgcc tcggtgtgcg gggtgcggaa
     5641 gatgaccgcc gtcgccgcgc tgctgccgcc gctgtggcgg gcggtcgccg acggggacgc
     5701 ccgctggggc tccgcgcgcc gcctgcacgc gctgtgggaa cggctgcggg cgaccgatcc
     5761 gcggctgccg ggggatccgg cggacgggat cgcggcgctg atcgacggct ggggcgtcgg
     5821 gcggcggatc gtggcgcccg gcgtggccga ggaggtcgcg cggcgcagcg tccgggcctg
     5881 gggttcgggg ctgccgatgc tcggcgcgtt ccgcggcgcg gacatcgcgc ggctcgtcga
     5941 gcgcacacag acttccgggt ttccggtcac ggcctgaccg gtcggcccac ggaaacacgg
     6001 atgcacaaaa gaaaaatgac catgaaaggg ggagaagaaa tgctgcactc tgtcgaggtt
     6061 cgtgagcagg acgaattcgc gctcgaactc ggaatgcagg agctggaggc cctggaggcc
     6121 ccgggctggt ggtcggtgac cggctacatc agcggcgccg gtgtcggtgg cgcggtgacg
     6181 tactccgtcg tcgccaccgc gatcagcgcg acctgatccg gaatcgatca catttcaccg
     6241 aacgacatga gaaggaggtg ttccatgcag gacaccaagg ctccgttctc gctcgacgac
     6301 atgccggccc tggagctggg catgcaggag ctggaggcca tggaggcccc cggtttctgg
     6361 agcaacttca aggagggcgt ctccgtctcc gtggccgtca gcgcggtcta cggcggcgtg
     6421 gcctccgcga tctccgcgac ctgatccgtc gaccggaggg gtgcgctccg gcgcactgta
     6481 ggatcccgcg agcgaatttc ccggacaact ttccgatgag cgtacgtagt tgaaatttgt
     6541 tccgcttgcg gagtgccggc cccggtcgac tcatgacctt ccggggccgg tgcccatgtg
     6601 tccgccacga tgaaaggaat cacatgtcgg aaaacgagtc ctggcgcgcg gccaacgcga
     6661 agctcgcgct ggtcatcccg gtcctcgtgg cgggcatcgc cgtcagtcag gtgtcgctcg
     6721 acggctgggc cgccgacggg ctgaccgtct tctgtgccgc cgccctgatc gccgtgctgc
     6781 tgcgcatcgg gctcaacgcc cgttcgggag gcggacggtg accgacacgg ccgttgcccg
     6841 cttcgacggc gtgacgaagc ggttcggtga cacggcggcc gtcgaggacg tgtccttcga
     6901 ggtccgtccc ggccggatcg tcggtctcct cggccgcaac ggcgcgggca agaccacctc
     6961 gctgcgcatg ctgctcggac tgacccggcc gacctcgggc cgggccaccg tgttcgggcg
     7021 gccgtacgcc gaactccccg gcgccgagcg ccgggtgggc gtcagcatgg acggcatcgg
     7081 aacgctgccc ggcgtcaccg ggcggcggga gctgtccatc tgggcgcgga tgctggagct
     7141 tcccgcctcg cgcgtggacg aggtgctgga gcagaccggc ctgaccgggg ccgccgacaa
     7201 gaagatcaag ggctactcga ccggtatgcg gcagcggcac gcgatggccg ccgcgctgct
     7261 cgccgacccc gagctgctgg tcctcgacga gccggcgaac ggcctggacc cggacggcat
     7321 ccgctggctg cggaccttcc tgcggtcgct cgccgaccag ggccgcacga tcctgctgtc
     7381 cagccatctg ctggccgagg tcgagcagac ggtcgacgac gtggtcgtcc tccagcgcac
     7441 cctgcgctac agcgggacgc tggccgagct gaccgaggac gggaagcacg ccctggagga
     7501 tcgtttcttc gagctcgtgg gcaccggagc cggcggcggg aacggagcag tcgtccatgc
     7561 gtaacgtcat cgccgccgag tggcgcaagg cctggaccgg ctccgcctgg tggctgctgc
     7621 cgctgtgcgg cgtcttcctg tccgtcctcg cgagcagcgg ctacgcggcc caggcggagg
     7681 agcagctcgc cgaccggcag accgacctcg tcgccgtcac cgacgagatg gtccgctcct
     7741 ggttcatgct gctgctcttc tccgccctgt tcggcgccgt cctcgtcacc cgcgagttcg
     7801 gctccggcgc catccaccgc tcggtgctgc tcggcggcac ccgcgaccgg ctgttcgcgg
     7861 ccaagctgat cgtcggcacc gcgatgggcg tgctgtacgc cgccctggcc gccggcctcg
     7921 ccgccgccag cccgtacgtc ttcctgcccg gcatcggcga gtcccccgaa tggtcggggg
     7981 acaccaccct caccctcctc ggcgtgttca ccgtgaccgt gctcggcgcc ccctggggcg
     8041 tgctgctcgg ctgggtgctg cgcaaccagg tcgccgccgt cggcaccctg ctggtgctga
     8101 cgctgctcgt cgacgagtcg ctgctgcggc tcgtgccgga cgccggccgg ttcaccatga
     8161 ccatcgccat gagctccgtc taccgcgacg gcaagcccga actgctctcc gtcccggtcg
     8221 ccttgctggt catcggagtg tggctggcgc tcgccgggtt cgtggggcgg cggctgttca
     8281 cccggcggga cctgaactga tgcgcgcgct ccagctgttg gagaggcggc ggagccccgc
     8341 ccccgccccg gccgaccacc tcacccgccc ccgcctcgcc cccgacgtcc gcgtccacgc
     8401 cccgctggcc accggcgcgc cctgggtggt gcagcgcggc agccagcagt acctgcgggt
     8461 cggcgccgac ctggcccggc tgctgcaggt gctcgacggc gagcgcggcc acgccggtct
     8521 ggtggcggag ctcggcccgc cgtggaccga gcaggccgtc ggccgggcgg tggcgagcct
     8581 cggcgagaag ggcctgctgg acgacggcag ccgcaaacgg cacagcggca cctggttcaa
     8641 gttcgtgccg ccgctcacct tccagctgac cctgctgaag ccggagcggc tgctgaacgc
     8701 cctcgccccg ctggtcgacc ggctcgcgaa ccgggccggc gcggtcgtcg ccgccgtcct
     8761 cgccctcggc ggcctgctcg cgctcgtcgc gcagggcccc gccctcgccg gcgcgctggg
     8821 cgagccgctg ccgctggccg tgctgctcgg cgtctcgctc ggctccaccg tgacgaccgc
     8881 cctgcacgag atcggccacg gcgcggtcct cacgtactac ggcggacgcc ccagccgcat
     8941 gggcgtgatg ctcttctacc tgacccccgc cttcttctgc gacgtctccg acggctggcg
     9001 gctgccgcac cgcgagcagc gggtgcgggt ggcgctcgcc gggatcgtca cccaggcggt
     9061 ggtcgccggc acggccgcct tcgcggcgct cgccaccggc ctcgcgggcg gcgcgcccac
     9121 gctgcgcgcc ggactgaccg tcttcgcggt ctccacgtac gtcaccggcg tcctcaacct
     9181 gctgccgttc gtgaagctcg acggctacct ggcgctgatg agccacctcg acacctcgca
     9241 cctgcgggac cgcgcgatga ccgacgcgcg ccgcctggtg gcgcgggtgc tgttcggcgg
     9301 ccggcgctac gaacgggagc tgcccgcgct gcgctgggcc ccggcgttcg gcctggcctg
     9361 catggtcttc ccgctctacc tgatcgggct ggccctcacc ctgtggctgg acatcctcac
     9421 cgggctcggc gtgatcggtg cctccgtggt cctcgccgcg ctggcctacc tcggctaccg
     9481 ggccggcaag ggcgcctccc tgctggtccg cgaggcccgc aaggggggcg cccggatctg
     9541 gcggctgctg ctcgcgggcg ccgtcgcggc ggcggggctc ggcgccgcgc tggccttcgt
     9601 caccgtgccg tacacgatca ccggcgggtt cgtctccgag gacggccgca cccggctggt
     9661 gctgtcggac gccgccgacc gggccgccgt ccgcgagggc gccgccgtca ccctgcagcg
     9721 ccgcgggctg gtgctgcgca cggacctcgg cacggccacc gtgaccggcg gggcgaagcc
     9781 cggcaccgcg ccgctgtcgg cgttcgtgcc ggtgcgcgag ggcgacgagc tgccggtacc
     9841 ggcgtacgag gtgccgctgg cgttcgacgg cggcacggac gaccacgcgg gcctggcccg
     9901 ggtggacgcg ggggaacggc cgctggggga gtggctgtac ctctcctacg tcgcgccggt
     9961 ctggcgctga cacctgatgg aacaccgacg gggatgagca atggacatcg ttcggcatct
    10021 gcacttctgc ccaccgggca cgcccttctt cgacgcaccg gcctccgccc ccgacccggc
    10081 ggacgacttc gggccggtgc gtgacgccct gccggccggc tggagccgca aggtcggcgg
    10141 cgagtgggtg cagtgggcgc cggacggcgt cgagatcccc ctccagggct ggaagatcca
    10201 cgcctcggcc accccggaca gcgcgcccgc gatcctcgac acggtcgtga agtactgcgt
    10261 cgccgagcgc gtgatgttca agttcatccg gagcctgccg gtgctgcggc ggcgcaacgg
    10321 caagtacggc gaccgcagcg cgagcggcaa gttcgtcacc ctctaccccg ccgacgaggc
    10381 gcggttcgag aagatcctgc gcgaactcgg cggcctgctc gaaggacagc ccggcccgta
    10441 catcctcagc gacctgcgct ggggccccgg cccgctgtac gtccgctacg gcggcttcgc
    10501 cctgcgcacc gcccgcaccg acaccggcga gcaggtgtac tgcgtcgagg accccgacgg
    10561 ccgcctcgtc cccgaccggc gcggccccgg cttccgcccg ccggagtggg tgacgctgcc
    10621 cgactgcctc gccgagtcgc tggccgcccg caacgcgggc accctcaagg acttcccgta
    10681 ccgggtcacc caggccctgc acttctccaa cggcggcggc gtctaccggg gcgtcgacac
    10741 ccgcaccggc gccgacgtcc tgctgcgcga ggcacggccg ctggccggac tggacggcga
    10801 cggccgcgac gccgtcgccc ggcacgaacg cgagcactgg gcgctgcggc ggctggacgg
    10861 gctggactgc atcccccggc tggtcgacta ccgcatcggg cacgagcact acttcctggt
    10921 gcgggagtac gtcgagggcc gctcgctgtc caaggagacg ctccggcgca acccgctgct
    10981 gctcggcgag acctccgcgc aggcccgcgc ggagtacgcg gcgtgggcgc tggacgtgct
    11041 ggagcagatc gaccggggcg tcacagcgat gcacggccgc ggcgtcgtct tcggcgacct
    11101 ccaccccggc aacgtcctcg tccttgacga cggcacggtc cggttcatcg acttcgagac
    11161 cgccagcgcg gtcgacgcgg acgccgcgca gaccatggcg gcggtcggct tcgccgcgcc
    11221 ggagggcgta cgcggggccg ccgtcgaccg gtacgcgctc ggctgcctgc ggctcgcgct
    11281 gttcgcgccg gtcgcggcgg tgctgccgtg gggaccggag aaggtgacgg aggcgctgga
    11341 actgatccgg gggcggttcc cggtgccggc ggacttcgcg gaggcggtac ggcgggacct
    11401 ggggctgccg gagacgccgg gggagccgtc cccgggcgtc tggcacggcg acccggcgga
    11461 atggccgcgg ctgcgggacg cgctcgccga gggcatcgcc ggtacggcca cccccgaccg
    11521 tactgaccgg ctcttccccg gcgacgccga gcagttcttc gcccccgagg gcggggtggg
    11581 cttcgcgtac ggcgcggcgg gtgtgctctg ggcgctcgcg gaggccgggg tgccggtccc
    11641 ggaggaccac accgactggc tgaccaaggc cgcgctggag ctgaacgagc cgcagcccgg
    11701 cttctggacc gggctcgccg gcatcgcgta cgccctcgac cgcctcggcc gcgccgacac
    11761 cgcccggcgg ctcgtggacc gcgccctcga cgagacggta cggccccgcc gcggcggcct
    11821 gctcgacggc gtgtccggcc tcggcctcac cgccctgcac ttcggcgaca cccacctgga
    11881 ggcggccgtc cgcctcgccg agacgatcac gccaacgccc gacaccggcc ggcctcccgg
    11941 cctcctgcac ggagcctccg gcaccgccct gttcctcata cggctgtacg agcggaccgg
    12001 ggacccggcg ctcctcgacc gcgccgggac cgccctgcgc gccgacctcg cggcgctcgg
    12061 ctggtcctcg gaggagggcc gcttcggcgc ggagtcggtg ggacggctgc cgctgatctc
    12121 cacgggcagc ggcggcacgg cactggtcct ccaggcctgg ctgcggcacc gcgaggaccc
    12181 ggacttcacc gccgcgcggg acgccgtaat ggccttgacg gagggccact tcgccccgca
    12241 ggccggggtg ttccacgggc gtgccggagt gctcgcggta cggctggggc tgggcgccgc
    12301 gggcgacccc cagggcctcc tcgacccctt cggcctgcac gtcgtcccgc acgacggccg
    12361 gcccgccttc ctcggccggg agaacctgcg cgtctcgacg gacttcgcga ccggcggggc
    12421 gggcgtgctc gccgtactgg acgcggcggt cggtgggcgg gtgccgcggc tgccgttcct
    12481 gtgagcggcc ggcgtcggct gcggttgctt ggagggttcg gcgtccgccg tggttgcttc
    12541 gggtggccgg cgtccgccgc cgctgcgacc gtcagccgtg tgcggtgcgc cgaccgccga
    12601 ccgccgaccg ccgaccgtcg ccgcgaccgt ctgccgaccg ccgaccgccg accgccgacc
    12661 gccgaccgcc gtctgtcgac cgccgaccgt cgccgcgacc gactgccgac tgccgaccgc
    12721 cgtcggcccc gcgatcgtcc gccgaccgcc gaccgccgtc cccccgcctt cctgacccgg
    12781 ccccttcacc cgaccgcccc cgggagccca cccatgatcg atgtcctccc cgccctggag
    12841 ccgagcgccg ggctggtcac gctgtcgcgg atcagtccgc ccgcaccccc ggccgacctg
    12901 ctgtggcggt gcacggtcga gctggcgcgg gccgaaccgg accgggcggg cggcgtgctg
    12961 agcgcacggc tggccggggc gcacgggcac tccagtacgg acgcgatgct gcgcggcgtg
    13021 ggtgaggcgg tcgaacggta cgcgctgcac cccgacggcc cggcgcccgc cggggcggtc
    13081 cgggcgacgg cggccgggct gggctcgcgc gcacagcgct tccacggccc ggacgtggcc
    13141 ctgggcgccg cgacggaccg cgaactgacc tggtacccgg cgacgcggct gcgcgacggg
    13201 gccaccgtgc tggtgccgag cgccctggtc gactacccgc tgaccggccc cgacgcggac
    13261 ggcttcgacc cgtcgccgtc cggcgcggcg gcgggcgagg gctggacggc ggccgtgcgt
    13321 tcggccctgc tggagacggt ggagcgggac gccttccagg tggcgtggga gcgcgacctg
    13381 cgcccggtcc gggtggccga cccgggcacc gaccgcacgc tgacccggct cctgcgccgc
    13441 gccgcccagg ccggtctgga agccgtcctc gcggaagtgc ccaccggcgt accgggcgtg
    13501 gcctgcgcga tcggcgtcgt cgtcgacgag gccgggcccc acccgctcgc caccctcggc
    13561 tgcaaggcct ccgacgaccc cgcccgccgc ctgctcggcg cgctccagga ggcgctgcag
    13621 atccggtcgg ccgcgctggt cgcccgtgag cgggccgacc ggtggccggg cggtgccgtg
    13681 cgggacgacg acgaccggct gcggttcctg gcctcccccg aggggtacgc gcgggtccgc
    13741 gcctggaccg acgcgttcgc ccaagacggt cccggtggtc ccggcgaccc cgccgcccgg
    13801 cgggtctcca ccgacgaact cgtccgcgcc atggtcaccg acggcgccga cccgctgatc
    13861 gtcgacctca cgcaccggct ccccctcggc gtgcgggagt cgggctgggc cgccgtcaag
    13921 gccgtaccgg tcggctacca gcagctgcgc atcgacgaca cccgcacgga cacctggaac
    13981 agggcgcggc tcgcgtccgc cgaggcccgt accggactga ccgcggggcc cgccccgacc
    14041 ggcgtacgcc cgcacccgct tccctgaagg accgtatgaa agccctcgtc ctcgccggcg
    14101 gcaccggcag ccggatgcgt ccgctcaccc acacggcggc caagcagctg atccccgtcg
    14161 gcaacaagcc gatcctcttc tacggcctgg aggcgctggt cgcggccggg gtgaccgaga
    14221 tcgggatcgt ggtgggggac acccaccgcg agatccggga ggcggtcggc gacagcggcc
    14281 ggttcggcgc gcgggtcacc tacctgcggc aggagcgtcc cctcggcctc gcccacgccg
    14341 tgctgatcgc ccgcgacttc ctcgccgacg acgacttcgt gctctacctc ggcgacaact
    14401 tcctggtcgg cggcatcgac gaggtcgtgg cggacttccg cgccgcccgg cccgacgccg
    14461 gtgtgctgct gacccgggtg cccgacccgt ccgcgttcgg ggtcgccgag ctgggccccg
    14521 acgggcggct ggcccggctg gaggagaagc cggccgagcc gcgcagcgac ctcgcggtgg
    14581 tcggcgtcta cctgttcacg ccggcgatcc acgaggccgt acgcgccgtc gagccgtccc
    14641 cgcggggcga gctggagatc accgacgccc tgcagtggct gatcgaccag gggcacgtgg
    14701 tccggccgac gctggtgaag gggtactgga aggacaccgg caccgccgcc gacctgctgg
    14761 ccgtcaaccg caccgtgctc gacggcctca cccccgaggt gcgcggctcg gtcgacgcag
    14821 gcagcgtgat cagcgggcgg gtgcgggtcg agcccggtgc ccgcgtggtg cggtcccggg
    14881 tggtcgggcc cgcggtgatc ggcgcggggg cggaggtcgt cgactcgtgc gtggggccgt
    14941 acaccgcgct ggcggagggc tgccgcgtcg tgcggagcgg ggtggccgac tcgatcgtgc
    15001 tgagccgcgc ggagatagcg ggggtcgggc gggtcgaggc ctcgctcgtc gggcggcacg
    15061 cgagcgtgca cagcaccgat catgtgtcca ccgcccaccg gcttgtcctc ggcgaccaca
    15121 gcagcgttca catcggacac tgaccccggg ccaccgaccc gcgcccccga cgccccttcc
    15181 gacgccctcc ccccgacgcc ctgcccctgc ccccaccgac ccgcgaccgc accgatcccc
    15241 gaccctcagg aaacccgtgc gcatcctcgt caccggcgga gccggcttca tcggctccca
    15301 cttcgtccgt ctcctgctgg gcccggaccc cgggtcccgc cccaccgccg tgaccgtgct
    15361 cgacgccctc acctacgccg gggacctcac ccggctggac gcggtggccg gcgacccccg
    15421 gtacgacttc gtgtacggcg acgtccgcga ccgcccgctg gtggaggaac tggtgggcgg
    15481 gcacgacgcg gtggtgcacc tcgccgccga gacacacgtc gaccgctcga tcggcggggc
    15541 gggcgagttc gtctccagca acgtcctggg cacccaggtg ctgctggacg cggtgctgcg
    15601 gcacgggcgc accctggtgc acgtctccac cgacgaggtc tacggctcga tcgcggaggg
    15661 ctcctggacg gaggactgcc cgcccgcgcc gcgctccccg tacgcggccg ccaaggcctc
    15721 ctccgacctg ctggcgctgg cgtaccacca cacccacggc ctggacgtcc gcgtcacccg
    15781 ctgctccaac aactacggcc cctaccagca cccggagaag ctcatcccgc gcttctccac
    15841 cctgctccta gacggcggcc gggtgccgct gtacggcgac ggccgcaacg tgcgggactg
    15901 gctgcacgtc gaggaccact gccgggccct gctgcgggtg ctgctggcgg gccgcgccgg
    15961 gcgggtctac aacatcggcg ggggtaccga gctgaccaac ctgcggctga cccggctgct
    16021 gctggacgcg ttcggcgcgg gcccggagcg gatcgagcgg gtgcccgacc gcaagggcca
    16081 cgacctgcgc tactcggtcg actccggccg gatccgccgc gagctgggct ggcgcccccg
    16141 gcactccttc gccgagggcc tggccgcgac cgtggactgg taccgggaca accgcgcctg
    16201 gtgggagcgg cacctggccg agcgcgaccc ggccgcggcc cctcagccga gcagccggac
    16261 cggctcgccg tccaggtagg cgcggatgtc ctcgaccgcc tgcccgtagt agcgggcgta
    16321 gttggcgcgg gtgacgtagc cgaggtgcgg ggtggccagc aggcgggggg cggtgcgcat
    16381 cgggtggccg gcgggcagcg gttcgacgtc gaacacgtcg acgcccgccc cggcgatccg
    16441 gccctcgtgc agcgcggcga gcagggcgtc ctggtcgacg atggccgcgc gggaggtgtt
    16501 gaccaggaag gcgtccggtt tcatcagggc gagttcgggg gcgccgagca ggccgcgggt
    16561 gcggtcggag aggaccaggt gcacggagac gacgtcgctc cgcgccagca gctcctcctt
    16621 gctcgcggcc cggcgcacgc cggcctcgcc ggcgcgttcg tcggtgaggt tgcggctcca
    16681 ggcgacgacg tccatgccga aggcctgccc gatcgccgcc acccggctgc cgatcttgcc
    16741 gaggccgagc agaccgagga cgcgtccgtg caggtcggcg ccgaccgtgg actgccaggg
    16801 gccgccctcg cgcaggccgg tgttctcctg gaccaggccg cgggccaggc cgaggatcag
    16861 cgcccaggtc agttccaccg gcggggtcga ggagctctcg gtgccgcaga cggtgacgcc
    16921 gtgggcccgg gcggcggcgt ggtcgatcac cgtgttgcgc atgccggtgg cgacgatcag
    16981 cctcagccgg ggcagccgcg ccagcagcga cgcggggaag gggacccgtt cgcgcagggt
    17041 cacgacgatg tcgaagccgg cgagagcggc ggcgagttcg tcctcgccgt cgaagtgctc
    17101 ggtgaagggg acgacgtcga cccggtcggc cacgggggac cagtcggcgg cggaggtgcc
    17161 ggcgttctgg aagtcgtcga ggagggcgca gcgcagtcgc atggcagtag tgtcctcgcc
    17221 ccggcggggg acgcgacgcg ggccccggtc gttcacctct gacggccggg gcccactggc
    17281 gtcccggatc cggccgcggc ggcgacactc ccccgagcaa cgcgttcacg cgcgcgcacc
    17341 gacgggccgg ttccgatgaa gtgatcacat cagaccgcgc caacggatcg ctaacatgtg
    17401 gccaacggtt ctccggggac ctgcccggcg gttggcgcga agtcgccctc cggccaccgg
    17461 gccgacaccg ggagacggcc ggaacggtag cggatcccgc cgggaaccgg cagtgagcgg
    17521 gtggcgggaa accgtcgtga tgagggcgga aatgcgccag agtgtgatgc ggttcggact
    17581 gctggggccg cccgttctct accagccgtg tgcggcccag ggcccccagg gcaccttcgt
    17641 acgcaccatt cgcagtccca aagcgcgcgc cctgctcgcc gtgctgctgc tggaggccgg
    17701 ccgggtcgtg ccggtcggct ccctcaagga cgccctgtgg ggcggcgcgc cgcccgcctc
    17761 cgcgcacgcc tccctgcaca accacgtcac ccggctgcgc cgcctgctcg acgaccccga
    17821 ccggctgcgc gccgtgccgc ccggctatgt gctgcgggtc gagccgttcg aactggacgt
    17881 ccatgtcttc gagcaccatg ccaccgccgc gcgcaccgcg cacgccgccc acgactggga
    17941 gcgggtcgtg cgcgaggccg gggccgcgct cgcgctgtgg cggggcacgc cgctgtgcgg
    18001 cctcccgccc gagctcggcg gctacgcctt cgtccagcgt ctcgaggagg cccggctgct
    18061 cctgctggag tggcgctacg acgccgagct ggccgtcggc ggggaccggc tcggcgaact
    18121 ggtgccggag ctcgcggaac tggccgccga gcacccgctg cgcgaggcct accagcgcca
    18181 gctgatgctc gccctgcacc gcaccgaccg ccgtgccgaa gccctggccg tccaccgcga
    18241 cctgcgcgcc cggctgctgg aggagctggg cgtggagccc ggcccggcgg tgcgggaggc
    18301 gcacctggag gtgctgcgcg cgctgccgcg caccgagccc gcggccgagc cggccccctc
    18361 ggacaccgcg gcggagaccg acgcggaggc ggctctgtcc gccccccgcc ccgcgcagct
    18421 cccgccgcca ccgccccact tcaccggccg taccgccgcc cgcgacgagc tgtgccgggc
    18481 gctgctggaa cccggtgccg tggccgtggt cagcgggatg gcgggggtgg gcaagagcgc
    18541 cctcgccctg cacgcggccc acactctggc ggaacgtttc cccgacggcc agctctacat
    18601 caacctgcac ggcgccaccc ccggcatgac ccccctcacc gccccccagg ccctcgccgc
    18661 cctgctgcgg gacctcggcg ccgagccccg ccgcatcccc gagcaccccg acgccgccgc
    18721 cgcgttgctg cgctccctgc tcgcccccac ccgcaccctc ctggtcctcg acgacgctgc
    18781 ccacgccgcc cagatccggc ccctgctgcc gggcggcccc ggctgcgcgg tcatcgtcac
    18841 cagccgctcc ccgctcaccg ccctcgacgg cgcccgccgc ttcccgctcg ccccgctcac
    18901 cggcgaggac agcgcggcac tgctgcgcgc ggtctccggc cgggacggcc tcgacgccgc
    18961 ccacccgctc gtcgacctca ccggccgcct cccgctcgcc ctgcgcgtcg tcgccgcccg
    19021 gctcgccgcc cgcaccgccc tcaccccgga cgtcctcgcc gaccagctgg ccgccaccgg
    19081 gagccgactg caccacctgg agtacgacga cctcagcgtg cgcagctccc tcgccgtcgc
    19141 ccacgacgcg ctcgccgcgt cctcccgcga ggccgaccgc gacgccgccc acgccctgcg
    19201 ccgcatcggc gccctcgacc tccccgccta cggcgccccc ctcctcgccc gcctcaccgg
    19261 caccgacgaa cgccgcgcgg aagccgcgct ggaccgcctg gtcgacgtgg cactgctgga
    19321 ggagacggcg tacggcaggt acgagccgca cgacctggta cgggatttcg cgagggaact
    19381 ggcggagaag cagacgggca cgggcgcgtc gggaacggac gtgggagggg agcacgaagg
    19441 ggcggacagc ggggagaccg gcgcagagcc gggcgaggcg gcaccggtga gcgaagggga
    19501 ggccgacgcc gaggcgcggg cactccctcg gacgggtgcg ggcacgggcg gcaccccgtc
    19561 ggcgccgggc cgcgccgacg accccagcac cgaggcgagc ggtgccgtgg agaccgccct
    19621 gcactggtac gcggcggtgg ccgaacgcgc cctcaccgcc atcgtcgaac ccggcctgga
    19681 ccaggacgac cgccgccgcc cgaccgccgc ccagcccccc gagcacgccg cccacgtcgc
    19741 cgccaccacc cccttccgct ccgcgaaggc ggccttcgcc tggggcgacc tggaactgcc
    19801 gaacatcgtc accctcgtcg agcggcacgc gggcgacccc gcccacgacc accgcaccgc
    19861 cgcctacgtc tccaccctca tccgcctcct cttcccgtac gtccagcgca gcggccgcgt
    19921 cgccgagatg gaggtgctgg gcggcgccgc gctcgacgcc gcccgccgcc tcggcgaccc
    19981 cgccgcggag gcgtacgccc tcggcgacct cgccggactg cacttcctca ccggccgcca
    20041 gggcgacgcc ctcgccctca acgaccgcgc cctggagatc tggcggcgcc tcggcgtcgt
    20101 ctcctggatc cgccgctgcc tgaacaaccg cggcctgctc ctcgaaggcc tcggccggta
    20161 cgccgagtcc gaggccgccc tgcgccagag cctcacctac tcccggcagc tgcgggaccc
    20221 gcacggcgag gccgtcacct acagccacct cggcaatctc tacgagcaca ccgacccgcg
    20281 cgccgccatc gaacagcacc ggcgctcact gtcgatcggc gtctcgatcg gcgcggtcat
    20341 cgtgcagcac tccgcgcact gcaacatcgg ctacgcccac ctcagcctcg gcgaaccggc
    20401 cgccgccgcc cggcacttcg aggagagcct gcgcatcctc ggctgccgcg gcgactggca
    20461 cggcgagtcc cagacccggc tcggcctggt gcgcgccctg cgtcagctcg gtctcacgga
    20521 ccgcgccgcg agcgagtgcg cggaactgat gcgccgcgcg gacgcccgcg ccgaccacta
    20581 caccggcggt ctcgcccgcc accagaacgg tctgctgctg cacgcccggg gtctgcacga
    20641 gcgggcgtac gacgagtggc gcaccgctct cgccgcgctg gacggcacgg acgacagcgc
    20701 ggtgacggcg gagctgcggg cgctgctggc cggcgccgac gcccgccgct gacggcccgg
    20761 ccggtcactt ggcgtcggca tagcactcca ccaccgccgt ggtgaacggg aaccgcaccg
    20821 gcgtctcccc gaacgtcagc cgccccgcca gctccgacgc ctcccggatc gccgcgacga
    20881 ccgtctccgc ctcctcctcg gggcagtgca cgatcacctc gtcgtgctgg aagaagacca
    20941 gctcggccgc caggccggcg caggccctgc gcagcgcggc gagcagcagc agcgcccagt
    21001 cggcggcgct gccctggacc acgaagttgc gggcgaaccg gccgcgggcg cgggcgtcgg
    21061 tcgaggcgta gcccggcacc cactgccggt cgtcaccgtc ctcgtccggc gccgggatgc
    21121 cggcctcctc cgccgcgtcg tcgcccgtgc gggccgccgg cgggcaggtc cggccgagcc
    21181 aggtgcgcac cagccgcccc tcctcaccgg cgcgggcggc gtcgtcgacg tacgccacgg
    21241 ccctggggaa gcggcggcgg agcgcggcga ggttcttcag gccgtccccg gaggtctgtc
    21301 cgtagaccgc gccgagcacc gcgagcttgg cctgggcgcg gtcgccggag aaggcgcggt
    21361 cggagaccga ctggtagagg tcgctctcgc ggcccgcgac ctccatcaga ccggggtcgc
    21421 gggagatcgc ggcgagcacg cgcggttcca tctggtcggc gtcggcgacg accagccgcc
    21481 agccggggtc ggcgacgacg gcccggcgga tcaccttggg gatctgcagg ccgcccccgc
    21541 cgttggtgac ccagcgcccg gtgacggtgc cgcccgcgag gaactcgggc cggaaccgcc
    21601 cgtcgcgcac ccagtcctgg agccaggacc agccgtgggc gacccagatc cggtacagct
    21661 tcttgtactc cagcagcggt ttcacggccg ggtggtcgac ggactcgagc tcccaccggc
    21721 gggtggacct gatcttgatc ccggcctgcg cgaacgcctt gacgacgtcg gcgggcaggt
    21781 cgggccgcac ccgccgcccg aacgcggcgg acacctcgtc ggccagctcg gcgaggcgcc
    21841 ggggctcgcc gccgcccgcg taccgctcgc cgagcaggtc gtgcagcacc gcgcggtgga
    21901 cgtccgtact ccacggcagt cccgcgcggt tcatctcggc ggccaccagc atgcccgccg
    21961 actcggcggc cgtcagcagc cgcatccggt ccgggtgggc cgtacggtcg tgccgccgct
    22021 gctgctcggc gtagacggcg agcaggtcgg ccaggggcag cgggcggtcc tgcggttcga
    22081 agagcgggga ctgcgcgccg ggttccgccg cgcgttgcgg cggatccggc gggacgggcc
    22141 cgccgcgcag ccgggccagg gcggcggcgg ccgaacgcgg ctcgccgtac cgcccctcgt
    22201 ggcccaggag gagggtttcg gcgtcctcga tgtcgtagca ccgctccact cgcacccccg
    22261 tggcgagcag acgcggatag acctcgtggg tggaccgcca cacccagcgc gtcacctcgg
    22321 gccgctcccg cacggcccgc gccaggtccg cctcccgcag caccggcccg gagggcagcc
    22381 cgtccgggcc gaggggggcg agctccacgc cgccgccctc ggccgctgcg agcgcccacc
    22441 ggtcggtcat gcaagcgagt gtggcacccg ggtctgacaa cggc
//
