LOCUS       NZ_LIVZ01000005        21098 bp    DNA     linear   CON 27-MAR-2024
DEFINITION  Streptomyces sp. TSRI0107 scaffold5, whole genome shotgun sequence.
ACCESSION   NZ_LIVZ01000005
VERSION     NZ_LIVZ01000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. TSRI0107
  ORGANISM  Streptomyces sp. TSRI0107
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 626176)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 626176)
  AUTHORS   Yan,X., Ge,H., Hindra,F., Yang,D., Huang,T., Crnovcic,I. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-AUG-2015) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2014
            Assembly Method                   :: CLC Genomics Workbench v. 7.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905845.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:50:25
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,745
            CDSs (total)                      :: 7,667
            Genes (coding)                    :: 7,467
            CDSs (with protein)               :: 7,467
            Genes (RNA)                       :: 78
            rRNAs                             :: 2, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 200
            CDSs (without protein)            :: 200
            Pseudo Genes (ambiguous residues) :: 0 of 200
            Pseudo Genes (frameshifted)       :: 85 of 200
            Pseudo Genes (incomplete)         :: 158 of 200
            Pseudo Genes (internal stop)      :: 13 of 200
            Pseudo Genes (multiple problems)  :: 51 of 200
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:19:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 42877
            Orig. end                         :: 63975
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LIVZ01000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21098
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21098
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21098
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11098](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11098
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(240..1577)
                     /gene="aroA"
                     /locus_tag="AMK31_RS13965"
                     /old_locus_tag="AMK31_13805"
     CDS             complement(240..1577)
                     /EC_number="2.5.1.19"
                     /GO_function="GO:0003866 - 3-phosphoshikimate
                     1-carboxyvinyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="aroA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018571327.1"
                     /locus_tag="AMK31_RS13965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_13805"
                     /product="3-phosphoshikimate 1-carboxyvinyltransferase"
                     /protein_id="WP_073940826.1"
                     /transl_table=11
                     /translation="MAHEAHPALWPAPHASGAVDATVHVPGSKSVTNRALVLAALASEP
                     GWVRRPLRSRDTLLMAGALRAMGVGIEETVSSSSVGAGAGDVTGEAWRVFPTGLRGPAT
                     VDVGNAGTVMRFLPPVAALADGPVRFDGDPRSYERPLHGVIDALRVLGARIDDDGRGAL
                     PLTVHGGGALDGGRVEIDASSSSQFVSALLLSGPRFNQGVEVRHVGAALPSLPHIRMTV
                     EMLRAVGAQVDTPESGGEPNVWRVTPGALLGRDLTVEPDLSNAQPFLAAALVTGGKILV
                     PDWPARTTQPGDRLREIFTEMGGSCELTEQGLRFTGSGAIHGIDVDLSEVGELTPGIAA
                     VAALADSPSTLRGVAHLRLHETDRLAALTKEINELGGDVTETADGLHIRPRPLHGGVFH
                     TYEDHRMATAGAILGLAVEGVQIENVATTAKTLPDFPELWTGMLGA"
     gene            complement(1673..2386)
                     /locus_tag="AMK31_RS13970"
                     /old_locus_tag="AMK31_13810"
     CDS             complement(1673..2386)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003992842.1"
                     /locus_tag="AMK31_RS13970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_13810"
                     /product="M50 family metallopeptidase"
                     /protein_id="WP_073940827.1"
                     /transl_table=11
                     /translation="MDSTTAASLWDELVGTQPEPDLWVVIATLVAALAVVVPQGLWRLA
                     RNAITIAHEGGHGLVALLTGRTLTGIRLHSDTSGLTVSRGKPYGLGMILTAAAGYTAPP
                     LLGLGGAALLASGRITLLLWLATALLLVMLVMIRNAYGVLTVVLTGAMFVLVSWLTGPQ
                     VQSAFAFAVVWFLLLGGVRPAFELQSKRRHGGAPDSDADQLARLTHAPAAVWLFLFHAV
                     SLCSLIGGGRWLLAL"
     gene            2438..3253
                     /locus_tag="AMK31_RS13975"
                     /old_locus_tag="AMK31_13815"
     CDS             2438..3253
                     /GO_function="GO:0003697 - single-stranded DNA binding
                     [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009432 - SOS response [Evidence IEA]"
                     /GO_process="GO:0018142 - obsolete protein-DNA covalent
                     cross-linking [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980380.1"
                     /locus_tag="AMK31_RS13975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_13815"
                     /product="SOS response-associated peptidase"
                     /protein_id="WP_073940828.1"
                     /transl_table=11
                     /translation="MCGRFAASRRPEDLAGVFEVEKWEPEETLAPDYNVAPTKEVYAVL
                     DRPLKDADDPRPVRQLRKLKWGLVPSWAKTPEGGARMINARAETVHEKPAYRRAFATRR
                     CIVPADGYYEWVTGKQERELEAEGKRKRPRKQPYFVLPADGSVFAMAGLYEFWRDRTLP
                     DDHPQAWWVTCSVITTEAETDPLAVAPAEGPYVLADIHPRMPLMLTPDRWDAWLDPSRT
                     EPEDLRALLAPPPPGLMRAYPVTTAVSNVRNNGPELLKELEGPEEGTLF"
     gene            3255..3905
                     /locus_tag="AMK31_RS13980"
                     /old_locus_tag="AMK31_13820"
     CDS             3255..3905
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010984469.1"
                     /locus_tag="AMK31_RS13980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_13820"
                     /product="alpha/beta family hydrolase"
                     /protein_id="WP_241842648.1"
                     /transl_table=11
                     /translation="MTRTETTEITELVETDAGTARITWRRAAKARLVLAVSHGAGGGVD
                     ARDLRALAAVLPGHGVTVALVEQPWRVAGKKMAPAPKTLDTGWRGVWPALSAPGLPVVS
                     GGRSAGARVACRTATELGAAGVLALAFPLHPPGKPEKSRAEELLGAGARTLVVQGGNDP
                     WGKPAEFPDGDFELVEVPYADHGLAVPKRAPLDQDEALAVVTDAVVKWTGALG"
     gene            4183..4878
                     /locus_tag="AMK31_RS13985"
                     /old_locus_tag="AMK31_13825"
     CDS             4183..4878
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973756.1"
                     /locus_tag="AMK31_RS13985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_13825"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_198948493.1"
                     /transl_table=11
                     /translation="MGPVSGTDAGTDNGQAELPEGQGISADASTETTAERSARFERDAL
                     EFLDQMYSAALRMTRNPADAEDLVQETYAKAYASFHQFREGTNLKAWLYRILTNTFINS
                     YRKKQREPQRSAAEEIEDWQLARAESHMSTGLRSAESQALDHLPDSDVKEALQAIPEEF
                     RIAVYLADVEGFAYKEIADIMGTPIGTVMSRLHRGRRQLRGMLEDYARERGLVPAGAGK
                     SDEAKGSGS"
     gene            4875..5177
                     /gene="rsrA"
                     /locus_tag="AMK31_RS13990"
                     /old_locus_tag="AMK31_13830"
     CDS             4875..5177
                     /GO_function="GO:0016989 - sigma factor antagonist activity
                     [Evidence IEA]"
                     /GO_process="GO:0045454 - cell redox homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rsrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136687.1"
                     /locus_tag="AMK31_RS13990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_13830"
                     /product="mycothiol system anti-sigma-R factor"
                     /protein_id="WP_073940829.1"
                     /transl_table=11
                     /translation="MSCGEPHETDCSEVLDHLYEFLDSEMPPVDRDKFQHHFEECSPCL
                     EKYGLEQAVKKLVKRCCGHDEVPTDLRAKVMGRIDMIRSGQAVPEHDVTATPQES"
     gene            5310..6617
                     /locus_tag="AMK31_RS13995"
                     /old_locus_tag="AMK31_13835"
     CDS             5310..6617
                     /EC_number="3.1.4.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015657918.1"
                     /locus_tag="AMK31_RS13995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_13835"
                     /product="HD-GYP domain-containing protein"
                     /protein_id="WP_073940830.1"
                     /transl_table=11
                     /translation="MEAVPARARVYVAGVALGALCCLAPLSAAGPPWWATALLAALYAG
                     GEQIAGRRFSGTCYPVLLAGAFLLAPPAAALVALPGALSARVEQRPAALRRIWRAAELV
                     LAVWASAQVFRALGGGAAVATADFPYALLPATGGVLAFCAALALLDGGVLVLAEHVPAR
                     RAWRGLFARSLAPLGVHGLAGLMMAVLWRSPYGPTASLLVLLPMCVSWWAFAQYHRERA
                     AHRATIRALVQAVDIKDGYTRGHSERVGQASMMIARELGMPDDRVEVLRFAGILHDVGK
                     LGVPTRLLRKDGPLTPEERRIIELHPEYGHEMVRGISFLCEARAAVLHHHERLDGSGYP
                     YGLVGTQIPESARVVAVADAFDAMTSTRSYARARPVEAALAELERCAGTHFDPRMVAAL
                     TQALTRYGWHPAVTADEMPAPRPPAAPVPGKEGARR"
     gene            6614..7855
                     /locus_tag="AMK31_RS14000"
                     /old_locus_tag="AMK31_13840"
     CDS             6614..7855
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019072152.1"
                     /locus_tag="AMK31_RS14000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_13840"
                     /product="metal-dependent phosphohydrolase"
                     /protein_id="WP_107468606.1"
                     /transl_table=11
                     /translation="MTAALPRTLIHTSAALVAAVSLAVTLWTGMTERGVALAFGALITL
                     GELSRWTGAARVREAAPLGAAGALSYALLGENAGRPTGHGAAQVLTVVVAASLLGCVPH
                     IARGRGPMYDHLARRVLTVAFAAACFQPLYNRGVFDDWTGTAYALLLIALLSLTALCDA
                     VLAAALAHARTDWPFVPLLRDGLRAMSGVGSAVCATGAVIALAVAVAGLWALPVFCVPL
                     LLTQVSVRRYAAVRATYRQTIASLARATEIAGYTPAGHAHRVAALSRAVGRDLGLSGSE
                     LTVLEYAALMHDIGQLSLVDPVPAGATAVLPAAEQRRIALLGGAVVRQTGVDRRVAEVV
                     ERQADACAEQPLAARIVRVVNAYEEKARSAGPGGPLTALEELRLATAGEYAPEVVEALA
                     RVLSRDCLTLPAGG"
     gene            7972..8952
                     /locus_tag="AMK31_RS14005"
                     /old_locus_tag="AMK31_13845"
     CDS             7972..8952
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889310.1"
                     /locus_tag="AMK31_RS14005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_13845"
                     /product="hypothetical protein"
                     /protein_id="WP_073940831.1"
                     /transl_table=11
                     /translation="MRIFGKGRHRPSASWRQATDRAFTLIGDGRYEDAGALLTRAADLE
                     PWLSESWFNLALLHKFRHDWEQARTAGLRAVALLDREAGAPDWWNVGIAATALQDWPLA
                     RRAWQAYGLQVPGGATDNGEPVGMDLGSAAVRLSPEGEAEVVWGRRLDPARIEVLSIPL
                     PSSGRRWGEVVLHDGVPHGERTTAVGHSYPVFDEIELWAPSPVPTWVVLLEAATEADRD
                     ALEQLAADAGFAAEDWSSSVRLLCRMCSESRMPADEGDGEHLDPHDHSEPGHPGPLGHR
                     TDGQLWVPERECGVAAPASLVRGLLDGWVADSPDSRDWRDLEEVC"
     misc_feature    9045..9054
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.85"
                     /tool="antismash"
     gene            9073..9723
                     /gene="def"
                     /locus_tag="AMK31_RS14010"
                     /old_locus_tag="AMK31_13850"
     CDS             9073..9723
                     /EC_number="3.5.1.88"
                     /GO_function="GO:0042586 - peptide deformylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="def"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1275: peptide deformylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004983603.1"
                     /locus_tag="AMK31_RS14010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_13850"
                     /product="peptide deformylase"
                     /protein_id="WP_073940832.1"
                     /transl_table=11
                     /translation="MAQQDTDQQHVGVLPVDDEGFVIDTEQCEEREAEWRGRGTSRPIT
                     VVGNPVLHKECKDVTDFGDEFQQLVADMFASQRTAEGVGLAANQIGVDLKVFVYDCPDD
                     EGVRHVGVVCNPKLVELPAENRRLDDSNEGCLSVPTAYMPLARPDYAEVTGQDEKGNPI
                     KVRGTGYFARCLQHETDHLYGYLYIDRLSKRDRKDALRQMAENEPRYPVVAND"
     misc_feature    complement(9853..9870)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     gene            10001..11098
                     /gene="cyc1"
                     /locus_tag="AMK31_RS14015"
                     /old_locus_tag="AMK31_13855"
     CDS             10001..11098
                     /EC_number="4.2.3.37"
                     /GO_function="GO:0052680 - epi-isozizaene synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cyc1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003992851.1"
                     /locus_tag="AMK31_RS14015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_13855"
                     /product="epi-isozizaene synthase"
                     /protein_id="WP_107468621.1"
                     /sec_met_domain="T1TS (E-value: 2.1e-62, bitscore: 206.9,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAFPHSTTATAVAVPPSLALPVIEAAFPRQLHPYWPRLQEKTRA
                     WLLEKRLMSADKVAEYADGLCYTDLMAGYYVGAPDEVMQAIADFSAWFFVWDDRHDRDI
                     VHRRPLAWSRLRSRLHTALDSPKDHLHHEDPLVAGFADSVLRLYSFLPGTWNAPGTWNA
                     RFARHFHAVIEAYDREFRNRAGGLVPTVEEYLELRRLTFAHWIWTDLLEPSAGRQLPDE
                     VRKHPAFRQAALLSQEFAAWYNDLCSLPKEIAGDEVHNLGISLVIHQGMSLETAVAEIR
                     RRIENCIADFLVAERDALRFADELADGTVQGKELSAAVRSCVANMRNWFSSVYWFHHES
                     GRYRVDSWEDRSTPPYVNNEAAGEK"
     gene            11095..12474
                     /locus_tag="AMK31_RS14020"
                     /old_locus_tag="AMK31_13860"
     CDS             11095..12474
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326965.1"
                     /locus_tag="AMK31_RS14020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_13860"
                     /product="cytochrome P450"
                     /protein_id="WP_073940834.1"
                     /sec_met_domain="p450 (E-value: 1.9e-74, bitscore: 246.1,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVESVKPPTSAAAQASQLREPPLAGGAVPLLGHGLKLVRDPLAF
                     MSRLREHGDVVRLKLGPKTVYAVTTPALTGALALSPDFKIDGPLWESLEGLLGKEGVAT
                     ANGPRHRRQRRTIQPAFRLDAIPAYGPIMEEEAHGLTTRWRPGETIDCTSESFRVAVRI
                     AARCLLRGEYMDERAERLCNALAVVFQGMYRRMVVPLGPLYRLPLPANREFNRALADLH
                     LLVDEIIAERRASGQKPDDLLTALLEAKDENGDPIGEQEIHDQVVAILTPGSETVASTI
                     MWLLQVLAAHPEHADRVREEVESVTDGRPVAFEDVRKLRHTNNVVVEAMRLRPAVWILT
                     RRAVTDTSLGGYRIPAGADIVYSPYAIQRDPHSYPDHLEFDPDRWLPERAKDVPKYAMS
                     PFSVGNRKCPSDHFSMAQLSLITAAIATKYRFEQVAGSDDATRVGITLRPQRLLLKPVP
                     R"
     gene            complement(12523..13536)
                     /locus_tag="AMK31_RS14025"
                     /old_locus_tag="AMK31_13865"
     CDS             complement(12523..13536)
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0009263 - deoxyribonucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674901.1"
                     /locus_tag="AMK31_RS14025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_13865"
                     /product="ribonucleotide-diphosphate reductase subunit
                     beta"
                     /protein_id="WP_073940835.1"
                     /transl_table=11
                     /translation="MSTRNQNLLDPGFELTLRPMRYPDFYERYRDAIKNTWTVEEVDLH
                     SDVADLAKLTPGEQHLIGRLVAFFATGDSIVANNLVLTLYKHINSPEARLYLSRQLFEE
                     AVHVQFYLTLLDTYLPDPDDRAAAFAAVENIPSIREKAEFCFKWMDSVEKLDRLETKAD
                     RRRFLLNLICFAACIEGLFFYGAFAYVYWFRSRGLLHGLATGTNWVFRDETMHMSFAFD
                     VVDTVRKEEPDLFDDQLQQQVTDMLREAVEAELQFARDLCGDGLPGMNTDSMRQYLECV
                     ADQRLSRLGFAPVHGSENPFSFMELQGVQELTNFFERRPSAYQVAVEGTVDLDEDF"
     gene            complement(13536..15896)
                     /locus_tag="AMK31_RS14030"
                     /old_locus_tag="AMK31_13870"
     CDS             complement(13536..15896)
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0009265 - 2'-deoxyribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015657909.1"
                     /locus_tag="AMK31_RS14030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_13870"
                     /product="ribonucleoside-diphosphate reductase subunit
                     alpha"
                     /protein_id="WP_073940836.1"
                     /transl_table=11
                     /translation="MTIAPADPASAATRSNDDGPGAALLRTLTELTADLPDADPGRVAA
                     AALRGRSAHADDAELRELATEAAAGLISEDPAYSRLAARLLAIGIAAEAASQGVTSFTE
                     SVAVGHREGLIADRTAEFVRLHADRLDALVDRTADDRFGYFGLRTLHSRYLLRHPITRK
                     VVETPQHFLLRVAAGLAEDDTTHSLDEVAALYALMSRLDYLPSSPTLFNSGTRHPQMSS
                     CYLLDSPKDELDSIYDRYHQVARLSKHAGGIGLSYSRIRSRGSLIRGTNGHSNGIVPFL
                     KTLDASVAAVNQGGRRKGAAAVYLETWHSDIEEFLELRDNTGEDARRTHNLNLAHWIPD
                     EFMRRVNADGQWSLFSPADVPELVDLWGEEFDAAYRRAEAAGLARKTIPARDLYGRMMR
                     TLAQTGNGWMTFKDAANRTANQTAEPGHVVHSSNLCTEILEVTDDGETAVCNLGSVNLG
                     AFVADGGIDWERLDATVRTAVTFLDRVVDINFYPTEQAGRSNAKWRPVGLGAMGLQDVF
                     FKLRLPFDSPEARALSTRIAERIMLAAYEASADLAERNGPLPAWEKTRTARGVLHPDHY
                     GVEPTWPERWAALRARIARVGMRNSLLLAIAPTATIASIAGAYECIEPQVSNLFKRETL
                     SGEFLQVNSYLVQDLKDLGVWDARTREALRESNGSVQDFAWIPQDVRRLYRTAWEIPQR
                     GLIDMAAARTPYLDQAQSLNLFMETPTIGKLSSMYAYAWKSGLKTTYYLRSRPATRIAR
                     AAQAQATVPVQQAADPEAVACSLENPESCEACQ"
     regulatory      complement(16043..16131)
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    complement(16146..16159)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.46"
                     /tool="antismash"
     misc_feature    complement(16153..16167)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: strong, score: 24.51"
                     /tool="antismash"
     misc_feature    complement(16184..16198)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: strong, score: 25.12"
                     /tool="antismash"
     gene            complement(16286..17896)
                     /locus_tag="AMK31_RS14035"
                     /old_locus_tag="AMK31_13875"
     CDS             complement(16286..17896)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444565.1"
                     /locus_tag="AMK31_RS14035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_13875"
                     /product="sodium:solute symporter family protein"
                     /protein_id="WP_073940837.1"
                     /transl_table=11
                     /translation="MKDGVNGVALAVFIFFFLAVTVMGFLAARWRKAENEHSLDEWGLG
                     GRSFGTWITWFLLGGDLYTAYTFVAVPAAIYAAGAAGFFAVPYTILVYPLIFTFLPRLW
                     SVSHKHGYVTTSDFVRGRFGSKGLSLAVALTGILATMPYIALQLVGIQAVLDVMGVGGG
                     EDTNWFIKDLPLLIAFGVLAAYTYSSGLRAPALIAFVKDTLIYIVIAVAIIYIPIKLGG
                     FDEIFAKADEKFTSAGAGGLVPPEAGQWTYATLALGSALALFMYPHSITATLSSKSREV
                     IRRNTTILPLYSLMLGLLALLGFMAIAAGIKVQNGQLAIPQLFETMFPDWFAGVAFAAI
                     GIGALVPAAIMSIAAANLFTRNIYKDFIRKDATPEQETKVSKLVSLLVKVGALAFVLTM
                     DKTVAINFQLLGGIWILQTFPALVGGLFTRWFHRWALLAGWAVGMLYGTIAAYGVASPT
                     QKHFGGSSKEIPGIGEIGYIGLTAFVLNVVVTVVLTFVLRAAKAPDGVDETKPEDYTAD
                     AGDPGVQVELPPATAGSAH"
     gene            complement(17893..18150)
                     /locus_tag="AMK31_RS14040"
                     /old_locus_tag="AMK31_13880"
     CDS             complement(17893..18150)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973741.1"
                     /locus_tag="AMK31_RS14040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_13880"
                     /product="DUF3311 domain-containing protein"
                     /protein_id="WP_073940838.1"
                     /transl_table=11
                     /translation="MSQAPEVNRGPVVTPVRVVIALCLVAPFVAMLWVGSYAKTDPALI
                     GIPFFYWYQMAWVLISTALTMIAFKLWQRDQRARRGGEQR"
     gene            complement(18263..19027)
                     /locus_tag="AMK31_RS14045"
                     /old_locus_tag="AMK31_13885"
     CDS             complement(18263..19027)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973740.1"
                     /locus_tag="AMK31_RS14045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_13885"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_073940839.1"
                     /transl_table=11
                     /translation="MSTDVSSAENEGGTTVRTARVPKYYRLKKHLLDMTETQAPGTPVP
                     PERTLAAEFDTSRTTVRQALQELVVEGRLERIQGKGTFVAKPKVSQALQLTSYTEDMRA
                     QGLEPTSQLLDIGYITADDRLAGLLDITAGGRVLRIERLRMANGEPMAIETTHLSAKRF
                     PALRRSLAKYTSLYTALAEVYDVHLAEAEETIETSLATPREAGLLGTDVGLPMLMLSRH
                     SLDREGKPVEWVRSVYRGDRYKFVARLKRPAE"
     misc_feature    19061..19074
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.09"
                     /tool="antismash"
     misc_feature    19102..19117
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 22.44"
                     /tool="antismash"
     misc_feature    complement(19249..19262)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.7"
                     /tool="antismash"
     misc_feature    complement(19273..19288)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: strong, score: 24.29"
                     /tool="antismash"
     gene            19371..20648
                     /locus_tag="AMK31_RS14050"
                     /old_locus_tag="AMK31_13890"
     CDS             19371..20648
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019523561.1"
                     /locus_tag="AMK31_RS14050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_13890"
                     /product="extracellular solute-binding protein"
                     /protein_id="WP_073940840.1"
                     /transl_table=11
                     /translation="MKRKLISAIGVAGMMISLAACGGDDGSGEGKGGADGYAGQTLTVW
                     VMDGSSPDQWQKDVAAAFEKKTKAKVKFEIQQWNGIQQKLTTALSEENPPDVFEIGNTQ
                     TPAYAKTGGLADLADLKTAIGGDWTESLNNSSVFEGKQYAAPWYFANRVVVYNKKVWAD
                     AGIKDLPKTRDEFYADLKQIGEKTDAEPIYLPGQNWYHFVGLVVGEGGELVKKDGDKYV
                     SNLDDPKVAAAMETYKKFQALSKAPKDKDEATPQQGEVFGKGKTGAFIGMGWEAGIAIE
                     ANPEIEKEIGYFTIPGATADKPEGVFLGGSNLAVAAGSQKQDLAKEFLKIALSDKYEGQ
                     LAKLNGVIPNKESLQGNVKGNAAAEAMAPAAAGGGTTPLIPEWAAVENAPNPVKTYMTA
                     VLNGKSPAEAAKQVEGEFNKRLAQQQ"
ORIGIN
        1 cgacccggtc gccgaccacg gccgccttgc ggcccagttc acgggccttc atcgcgacca
       61 ccggccggtc ctcgacgagg caggtcagcc tgccccggtc gacggtgagg accatgccct
      121 cggcggcgtc ctcgtgcttg ggccggatgt tcgtacgcgg ccggttgccc ttgcggttgg
      181 gacggctgcg gatgtcgtcc tcgtcggtgt gcttgccgta gcggcgcatc gcgatgtccc
      241 tatgccccga gcatcccggt ccacagctcg gggaagtccg ggagggtctt cgccgtcgtc
      301 gccacgttct cgatctgtac gccctcgacc gccaggccga ggatcgcgcc ggcagtggcc
      361 atgcggtggt cctcgtacgt gtggaagacg ccgccgtgca gcgggcgcgg gcggatgtgg
      421 agaccgtcgg cggtctcggt gacatcgccg ccgagttcgt tgatctcctt ggtgagggcc
      481 gccagccggt ccgtctcgtg cagccgcaga tgcgctacgc cccgcagtgt cgagggggag
      541 tcggcgagcg cggcgaccgc cgcgatgccc ggggtcagct cgccgacctc gctcaggtcg
      601 acatcgatgc catggatggc ccccgaaccg gtgaaccgca gaccctgttc cgtcagctcg
      661 caggaaccgc ccatctcggt gaagatctcg cgcagccggt caccgggctg cgtggtccgg
      721 gccggccagt ccgggacgag gatcttgcca ccggtgacca gggccgccgc gaggaacggc
      781 tgggcgttgg acagatccgg ctcgacggtc aggtcacggc cgagcagcgc acccggcgtg
      841 acccgccaca cgttcggttc gccgcccgac tcgggggtgt ccacctgggc gccgaccgcg
      901 cggagcatct ccaccgtcat ccggatgtgc ggcagcgagg gcagcgcggc accgacgtgc
      961 cgcacctcca caccctggtt gaaccgcggc cccgacagca gcagcgccga cacgaactgc
     1021 gaggacgagg acgcgtcgat ctcgacccgg ccgccgtcca gggcgccccc gccgtgcacg
     1081 gtcagcggca gcgcgccccg cccgtcgtcg tcgatccggg cgcccaggac gcgcagcgcg
     1141 tcgatgacgc cgtgcagggg acgctcgtac gacctcgggt cgccgtcgaa ccggaccggg
     1201 ccgtcggcga gcgcggcgac cggcggcagg aaccgcatca ccgtgccggc gttgccgacg
     1261 tcgaccgtgg ccgggccgcg cagccccgtg gggaacaccc gccaggcctc gcccgtgacg
     1321 tcaccggccc cggcgccgac cgagctggac gacacggtct cctcgatccc cacgcccatc
     1381 gcccgcaggg caccggccat cagcagggtg tcgcgggagc gcagcgggcg gcgcacccag
     1441 cccggctccg aggcgagcgc ggcgagcacg agggcgcggt tggtgaccga cttggacccc
     1501 ggcacgtgga ccgtcgcgtc gacggctccg ctcgcgtggg gggcgggcca gagggcgggg
     1561 tgtgcttcgt gggccatagg gccactttat aaggaggccg ctgttcgggt gcggcgccgt
     1621 tgtggctggt cgcgccccgc gcggtacggc ctcgcgcccc cgccgccggc cgtcacaggg
     1681 ccagcagcca ccgcccgccg ccgatcagcg agcacagcga caccgcgtgg aagaggaaca
     1741 gccacaccgc ggccggcgcg tgcgtcagcc tcgccagctg gtcggcgtcg gaatcgggcg
     1801 ctccgccgtg ccgccgcttc gactgcagct cgaacgccgg gcgcactccg cccagcagca
     1861 ggaaccagac cacagcgaac gcgaacgccg actgcacctg gggccctgtg agccaggaca
     1921 ccagtacgaa catggctccc gtcagcacca ccgtcagcac cccgtaggcg ttccggatca
     1981 tcaccagcat caccagcagc agggccgtcg ccagccacag cagcagggtt atgcggccgg
     2041 aggccagcag ggccgcgccg cccaggccca gcaggggcgg cgcggtgtag ccggcggcgg
     2101 ccgtgaggat catgcccagg ccgtacggct tgccgcggct gacggtgagg ccgctggtgt
     2161 cggagtgcag ccggatgccg gtgagggtgc ggccggtgag cagggcgacc aggccgtggc
     2221 cgccctcgtg ggcgatggtg atcgcgttgc gggcgagtcg ccacaggccc tgggggacga
     2281 cgacggcgag ggcggcgacc agggtggcga tcaccaccca caggtcgggc tcgggctggg
     2341 tgccgacgag ttcgtcccag agggaggcgg cggtggtgct gtccatgatt gctcgagcgc
     2401 tccctctcgt cgtgcggagt ctggcagtgt ggcacgtatg tgcggacggt ttgcagcgag
     2461 tcgtaggccc gaggatctcg cgggcgtctt cgaggtcgag aagtgggagc cggaggagac
     2521 cctggcaccc gactacaacg tggcgccgac caaggaggtc tacgcggtcc tggaccgtcc
     2581 tctgaaggac gccgacgacc cgcgcccggt tcgccagctg cgcaagctca agtggggcct
     2641 ggtgccgtcc tgggcgaaga cccccgaggg cggcgcccgg atgatcaacg cccgcgcgga
     2701 gaccgtccac gagaagcccg cctaccgccg cgccttcgcc acccggcgct gcatcgtgcc
     2761 cgccgacggc tactacgagt gggtcaccgg caagcaggag cgggagctgg aggccgaggg
     2821 caagcggaag cggccccgca agcagcccta cttcgtgctg cccgccgacg gctcggtctt
     2881 cgcgatggcc gggctgtacg agttctggcg ggaccgcacg ctgcccgacg accacccgca
     2941 ggcctggtgg gtcacctgct cggtgatcac caccgaggcg gagaccgacc cgctcgccgt
     3001 cgcgcccgcc gagggcccgt acgtgctcgc cgacatccac ccccggatgc cgctgatgct
     3061 caccccggac cgctgggacg cctggctgga cccgtcccgc accgagcccg aggacctgcg
     3121 cgccctgctc gccccgccgc cgcccggcct gatgcgcgcc tacccggtga ccacggccgt
     3181 cagcaacgtc cgcaacaacg gaccggagtt gctgaaggag ctggaggggc ccgaggaggg
     3241 cacactcttc tgatgtgacc aggactgaga ccaccgagat caccgagctc gtcgagaccg
     3301 acgccggaac cgcccgcatc acctggcgcc gggcggcgaa ggcccgtctc gtgctcgccg
     3361 tcagccacgg cgcgggcggc ggcgtcgacg cccgcgacct gcgggcgctg gcggcggtgc
     3421 tgccggggca cggcgtgacc gtggccctcg tcgagcagcc gtggcgggtg gccgggaaga
     3481 agatggcgcc cgcgccgaag acgctggaca ccggctggcg gggcgtctgg cccgcgctga
     3541 gcgcgccggg gctgccggtg gtctccggcg ggcggagcgc gggcgcccgg gtggcctgcc
     3601 gtaccgccac ggagctgggc gcggccgggg tgctggcgct cgccttcccg ctgcacccgc
     3661 cgggcaagcc ggagaagtcc cgcgccgagg agctgctggg ggcgggggcg cgcacgctgg
     3721 tcgtgcaggg cggcaacgat ccgtggggga agccggcgga gttccccgac ggggacttcg
     3781 aactggtcga ggtgccgtac gccgatcacg gcctcgcggt gccgaagcgg gcgccgctgg
     3841 accaggacga ggccctggcg gtcgtcaccg acgcggtcgt gaagtggacc ggcgcactcg
     3901 ggtgacgcgc cgggaatgac cggcgggtga ccgctgttgc agcggacaga agtgctgacg
     3961 accagcaccg acgtcgtagg agaggaagtc cgccgcatgg gttcgacctt ttgcccgagc
     4021 cgcagcagcc gcgctgacct ggactggacg gtgctgcacg cggccaagac ggcaccgctt
     4081 cgcgcggcgg gcggaacgga tcgacaggcg tccccgacgg tgggtcgtct atcctccgat
     4141 tccagtggga cctttttggg tcccgtccgg aactttgagg aggtgggtcc ggtcagcggt
     4201 accgacgcag ggaccgacaa cggccaggcg gagctgcccg agggccaggg catcagcgcg
     4261 gacgcgagca cggagacgac cgcggagcgc agcgcgcgct tcgagcggga cgcgctcgaa
     4321 ttcctcgacc agatgtactc ggccgcgctg cgcatgacgc gcaacccggc cgacgccgag
     4381 gacctggtgc aggagacgta cgcgaaggcg tacgcgtcct tccaccagtt ccgcgagggc
     4441 accaacctca aggcgtggct gtaccggatc ctcacgaaca cgttcatcaa ctcgtaccgc
     4501 aagaagcagc gtgaacccca gcgcagcgcg gccgaggaga tcgaggactg gcagctggcc
     4561 cgtgccgagt cgcacatgtc gacgggtctg cgctccgcgg agtcgcaggc gctcgaccac
     4621 ctgcccgact cggacgtgaa ggaagcgctc caggccatcc cggaagaatt ccgcatcgcc
     4681 gtgtatctcg ccgacgtaga gggctttgcg tacaaggaga tcgcggacat catggggaca
     4741 cccatcggta cggtgatgtc ccggctgcac cggggccgcc gtcaactgcg cgggatgctc
     4801 gaggactacg cccgcgagcg cgggctggtc ccggccggcg ccggtaagtc ggacgaagcg
     4861 aaaggctcgg gctcatgagc tgcggagagc cgcacgagac ggactgcagt gaggtcctgg
     4921 accacctgta cgagttcctc gacagcgaga tgccgcccgt cgaccgggac aagttccagc
     4981 accacttcga ggagtgctcc ccgtgcctgg agaagtacgg gctggagcag gccgtgaaga
     5041 agctggtcaa gcggtgctgc gggcatgacg aggtgccgac cgacctgcgc gccaaggtca
     5101 tggggcgcat cgacatgatc cgctccgggc aggccgtgcc cgagcacgac gtgacggcca
     5161 caccgcagga gtcctgagcc tcctcccggc ggccggccgc cgtcacccga acgtgctaat
     5221 cggcggacca tcggtccgca ccctccccct cgccgcccta ggctcccagc ccgaaacagg
     5281 caggaacggg ggcggggagg ggcggcgtca tggaggcggt tccggcacgg gcccgggtgt
     5341 acgtcgccgg tgtcgcactg ggcgcgctgt gctgtctcgc gccgctgtcc gccgcagggc
     5401 cgccctggtg ggcgacggcc ctgctggccg ccctctacgc gggtggtgag cagatcgccg
     5461 gccggaggtt ctccggcacc tgctaccccg tgctcctcgc cggcgccttc ctgctggcac
     5521 cgcccgccgc cgcgctcgtc gcgctgccgg gggcgctgtc ggcccgggtc gagcagcggc
     5581 ccgcggcgct ccgccggatc tggcgggccg ccgagctggt cctcgccgtc tgggcctcgg
     5641 cacaggtgtt ccgggcgctg ggcggcgggg cggccgtcgc gaccgccgac ttcccgtacg
     5701 cgctgctgcc cgccacgggc ggcgtgctgg cgttctgcgc ggcgctcgcc ctgctcgacg
     5761 gcggtgtcct ggtgctcgcc gagcacgtgc ccgcccgccg ggcctggcgg ggcctgttcg
     5821 cgcgctcgct cgccccgctc ggggtgcacg ggctggccgg gctgatgatg gccgtgctgt
     5881 ggcgcagccc ctacgggccg accgcctcgc tgctcgtgct gctgccgatg tgcgtctcgt
     5941 ggtgggcgtt cgcccagtac caccgggagc gggccgccca ccgggccacc atccgggccc
     6001 tggtgcaggc cgtcgacatc aaggacggat acacccgggg ccacagcgaa cgcgtcggac
     6061 aggcctcgat gatgatcgcc cgcgagctgg gcatgcccga cgaccgcgtc gaggtgctgc
     6121 ggttcgccgg gatcctgcac gacgtgggca agctcggcgt acccacccgg ctgctgcgca
     6181 aggacgggcc gctgacgccc gaggagcggc ggatcatcga gctgcacccc gagtacgggc
     6241 acgagatggt gcggggcatc tccttcctct gtgaggcccg ggccgccgtg ctccaccacc
     6301 acgagcggct ggacggcagc ggatacccct acgggctcgt cggcacccag atcccggagt
     6361 ccgcgcgggt ggtcgccgtc gccgacgcct tcgacgcgat gacctccacc cggtcctacg
     6421 cgcgcgcccg gcccgtcgag gccgcgctgg ccgagctgga gcggtgcgcc gggacgcact
     6481 tcgacccgcg catggtggcg gccctcacgc aggccctgac ccggtacggc tggcatccgg
     6541 cggtcaccgc ggacgagatg ccggcgcccc ggccgcccgc cgcgcccgtc cccggcaagg
     6601 agggggcgcg ccgatgaccg ccgccctgcc ccgcaccctc atccacacca gcgccgccct
     6661 cgtcgccgcc gtctccctcg ccgtcaccct ctggaccggg atgacggaac gcggggtcgc
     6721 cctcgccttc ggcgcgctga tcacgctcgg cgaactcagc cggtggaccg gggccgcccg
     6781 ggtcagggag gcggcgccgc tcggggccgc cggggcgctg tcgtacgcgc tgctcgggga
     6841 gaacgcgggc cggcccaccg ggcacggggc cgcccaggtc ctcacggtcg tggtcgccgc
     6901 ctcgctgctc ggctgcgtcc cgcacatcgc gcgcggccgg ggcccgatgt acgaccatct
     6961 ggcgcgccgg gtgctcaccg tcgccttcgc cgccgcctgc ttccaaccgc tctacaaccg
     7021 gggcgtgttc gacgactgga ccggcaccgc ctacgcgctg ctgctgatcg cgctgctctc
     7081 cctcaccgcg ctatgcgacg ccgtgctcgc cgccgcgctg gcgcacgccc gtaccgactg
     7141 gccgttcgtg ccgctgctgc gggacgggct gcgggccatg tccggagtgg ggtccgcggt
     7201 gtgcgcgacc ggggccgtga tcgcgctcgc ggtggccgtc gccgggctgt gggcgctgcc
     7261 cgtgttctgc gtgccgctgc tgctcaccca ggtctccgtc cgccggtacg ccgccgtgcg
     7321 cgccacctac cggcagacca tcgcctccct cgcgcgcgcc accgagatcg ccgggtacac
     7381 cccggccggg cacgcccacc gggtggccgc gctcagccgg gccgtcggcc gggacctggg
     7441 gctgtccggg agcgagctga ccgtgctgga gtacgcggcc ctgatgcacg acatcgggca
     7501 gctgagcctg gtcgacccgg tgccggccgg ggccaccgcc gtactgcccg ccgccgaaca
     7561 gcggcggatc gcgctgctgg gcggggccgt cgtccggcag accggggtgg accggcgggt
     7621 ggcggaggtg gtggagcggc aggccgacgc ctgcgcggag cagccgctcg ccgcgcggat
     7681 cgtgcgggtg gtgaacgcct acgaggagaa ggcgcggtcc gcggggcccg gcgggccgct
     7741 gaccgcgctg gaggaactgc ggctggcgac ggccggggag tacgccccgg aggtggtcga
     7801 agccctggcc cgagtgctgt ccagggactg tctgaccctg cccgcaggtg ggtaacccat
     7861 gggtaatgag cgcctctcca ggcgtacgtg gttggatgcg aaggagaggg agtccgagag
     7921 gctgtccggg ggcacagccg gcccactcca caaaactggc aggcgggaat cgtgaggatc
     7981 ttcggcaagg gacggcaccg gccctccgcc tcctggcggc aggccaccga ccgtgcgttc
     8041 acgctgatcg gcgacggccg gtacgaggac gcgggcgcgc tgctgacacg ggccgccgac
     8101 ctcgagccct ggctgtccga gtcctggttc aacctggccc tgctgcacaa gttccggcac
     8161 gactgggagc aggcccgcac ggccggcctg cgggccgtcg cgctgctgga ccgggaggcc
     8221 ggggcgcccg actggtggaa cgtcggcatc gccgccaccg ccctccagga ctggccgctg
     8281 gcccggcggg cctggcaggc gtacggactc caggtgcccg gcggcgccac cgacaacggg
     8341 gaacccgtcg gcatggacct gggcagcgcg gccgtgcggc tgtcgcccga gggcgaggcc
     8401 gaggtggtgt gggggcggcg gctggacccc gcgcgcatag aggtgctgtc cattccgctg
     8461 ccgtcgtccg ggcggcgctg gggcgaggtc gtactgcacg acggggtgcc gcacggcgag
     8521 cggaccacag ccgtggggca ctcctatccg gtgttcgacg agatcgagct gtgggcgccg
     8581 tcgccggtgc cgacctgggt ggtgctgctg gaggcggcca ccgaggcgga ccgggacgcg
     8641 ctggagcagc tggccgcgga cgccgggttc gccgcggagg actggtcgtc gtcggtgcgg
     8701 ctgctgtgcc ggatgtgctc ggagtcgcgg atgccggcgg acgaggggga cggggagcac
     8761 ctcgatcccc acgatcacag tgagccgggg catccggggc cgctggggca tcggacggac
     8821 gggcagttgt gggtgccgga gcgggagtgc ggggtggctg cgccggcttc gctggtcagg
     8881 gggttgttgg acggctgggt tgcggacagc ccggactctc gtgactggcg ggacctcgaa
     8941 gaggtctgct agcgccgttg ccggatctcc gtagtggggg ttgatcgcgc agttccccgc
     9001 gcccctcgcg gcgtcacccg taccctgtat cagcatcacc accctgtttt tctaggaagg
     9061 catacgtcgg tcatggcgca gcaggacacc gatcagcagc acgtgggcgt gctccccgtg
     9121 gacgacgagg gcttcgtcat cgacaccgag cagtgcgagg agcgggaggc cgagtggcgc
     9181 gggcggggta cctcgcggcc gatcacggtc gtcggcaacc ccgtgctgca caaggagtgc
     9241 aaggacgtca ccgacttcgg tgacgagttc cagcagctcg tcgcggacat gttcgccagc
     9301 cagcgcaccg ccgagggcgt gggcctggcc gccaaccaga tcggcgtcga tctgaaggtc
     9361 ttcgtctacg actgcccgga cgacgagggc gtgcgccacg tcggcgtggt ctgcaacccg
     9421 aagctggtcg agctgccggc ggagaaccgc cgcctcgacg acagcaacga gggctgcctg
     9481 tcggtgccga ccgcgtacat gccgctcgcc cggccggact acgccgaggt gaccgggcag
     9541 gacgagaagg gcaacccgat caaggtgcgg ggcaccggat acttcgctcg gtgtttgcag
     9601 cacgagaccg accacctgta cggctacctg tacatcgacc ggctgtcgaa gcgggaccgc
     9661 aaggacgcgc tgcggcagat ggccgagaac gagccccgct accccgtggt cgcgaacgac
     9721 tgacctcgtc cgcctcatcc gtacggcgcc cgaccgggct tcccttcccg gtcgggcgcc
     9781 gttcgtctgt ccgtcgcacg ttcgaccgtg tcccttcctt agtgatccag aaccagtcac
     9841 gcaagagggg tgtctcggca gtatggggta gtgagtgaag caaatccgtt cccagaacgg
     9901 tcagttgtgg tgctgaatgg taagtgcggg attacgcaac ggcgcacgcc cggcacgacg
     9961 gagaggcgtg cgccaaccgg cggctgagag gggtttgttc gtgcctgctt tcccacacag
    10021 caccaccgcg accgcggtcg ccgttccacc gtcgctcgca cttccggtga tcgaggcggc
    10081 gtttcccagg caattgcacc cgtattggcc caggctccag gagaagactc gtgcctggct
    10141 cctggaaaaa cggctcatgt cggcggacaa ggtggcggaa tatgccgacg gcctgtgcta
    10201 caccgacctg atggcggggt actacgtcgg cgccccggac gaggtcatgc aggcgatcgc
    10261 ggacttcagc gcgtggttct tcgtctggga cgaccgccac gaccgggaca tcgtccaccg
    10321 ccgtccgctc gcctggagcc ggctgcggtc ccggctgcac acggcactcg actcccccaa
    10381 ggaccatctg caccacgagg acccgctggt ggcggggttc gccgacagtg tgctgcggct
    10441 gtactccttc ctgccgggaa cgtggaacgc accgggaacg tggaacgcgc ggttcgcccg
    10501 gcacttccac gcggtgatcg aggcgtacga ccgggaattc cgcaaccgtg ccggggggtt
    10561 ggtccccacg gtcgaggagt atctggaact gcgccgcctc actttcgcgc actggatctg
    10621 gaccgatctg ctggagccga gcgcgggacg tcaactcccg gacgaggtac ggaaacaccc
    10681 ggcattccgg caggcggcac tgctgagcca ggaattcgcc gcctggtaca acgacctctg
    10741 ctcgctgccc aaggaaatcg cgggcgatga ggtccacaat ctcggcatca gtctcgtcat
    10801 ccatcaggga atgagcctgg aaacggcggt cgccgaaata cggcgccgga tcgagaactg
    10861 catagccgac tttctcgtcg ccgagcggga cgccctgcga ttcgccgacg agctggccga
    10921 cggcacggta cagggaaagg aattgagcgc cgccgtgcgg tcctgcgtcg cgaatatgcg
    10981 gaactggttc agctccgtct actggttcca ccacgagtcc ggccggtacc gggtcgacag
    11041 ctgggaggac cggtccacac ccccgtacgt caacaacgaa gcggcaggtg agaaatgacc
    11101 gtcgagtccg tgaagccccc gacctccgcg gccgcccagg cgtcgcagct gcgcgaacca
    11161 cccctcgcgg gaggggccgt accactcctc gggcacggcc tgaagctggt ccgcgacccg
    11221 ctggccttca tgtcccggct gcgtgagcac ggggacgtcg tccggctgaa gctgggaccc
    11281 aagaccgtct acgcggtcac caccccggcg ctcaccgggg ccctcgcgct gagccccgac
    11341 ttcaagatcg acgggccgct gtgggagtcc ctggagggcc tgctcggcaa ggagggcgtg
    11401 gccaccgcca acggcccccg gcaccgccgc cagcgccgca ccatccagcc cgccttccgg
    11461 ctcgacgcca tccccgccta cgggccgatc atggaggagg aggcgcacgg gctgaccacc
    11521 cgctggcggc ccggcgagac catcgactgc acctcggagt ccttccgggt ggccgtgcgg
    11581 atcgcggccc gctgcctgct gcgcggcgag tacatggacg aacgcgccga gcggctgtgc
    11641 aacgcgctcg cggtcgtctt ccagggcatg taccggcgga tggtcgtccc gctggggccc
    11701 ctgtaccggc tgccgctgcc ggccaaccgg gaattcaacc gggcgctggc cgatttgcat
    11761 ctgctcgtcg acgagatcat cgccgagcgc cgggcatccg gtcaaaagcc ggacgatttg
    11821 ctgacggcat tgctggaggc gaaggacgag aatggcgacc ccatcgggga gcaggagatc
    11881 cacgatcagg tggtggcgat actcaccccc ggaagcgaaa ccgtggcctc cacgatcatg
    11941 tggctgctcc aggtgctcgc ggcacatccg gaacacgcgg accgggtcag ggaagaagtt
    12001 gaatccgtga cggatggccg tccggtggca ttcgaggacg tccgcaagct gcggcacacc
    12061 aacaatgtcg tcgtcgaggc gatgcgtttg cgcccggccg tctggatatt gacccggcgg
    12121 gcggtcaccg acacctcgct cggcggctat cgcattccgg ccggagccga catcgtgtac
    12181 agcccgtacg cgatccagcg cgatccgcac tcgtacccgg accacctcga gttcgacccc
    12241 gaccgatggc ttccggaacg cgccaaggac gtgccgaaat atgccatgag ccccttcagt
    12301 gtgggtaatc ggaagtgccc gagcgaccac ttctcgatgg cccagctgtc gctcatcacc
    12361 gcggcgatcg cgacgaagta ccggttcgag caggtggccg gctccgacga cgccacccgc
    12421 gtgggcatca ccctccgtcc gcagcggctg ctgctgaagc ccgtaccgag gtgagggaag
    12481 acgggccggg gccggccctc gtgccggccc cggccgcggg gctcagaagt cctcgtccag
    12541 gtccacggtg ccctcgaccg cgacctggta cgcggacgga cgccgctcga agaagttggt
    12601 cagctcctgc actccctgca gctccatgaa ggagaacggg ttctccgagc cgtggaccgg
    12661 ggcgaagccc agccggctga gccgctggtc ggccacgcac tccaggtact gccgcatcga
    12721 gtcggtgttc atgcccggca ggccgtcccc gcacaggtcg cgcgcgaact gcagctccgc
    12781 ctccacggcc tcccgcagca tgtccgtcac ctgctgctgg agctggtcgt cgaagaggtc
    12841 cggctcctcc ttgcggacgg tgtcgaccac gtcgaacgcg aagctcatgt gcatcgtctc
    12901 gtcacggaac acccagttgg tgccggtcgc gagaccgtgc agcaggcccc ggctgcggaa
    12961 ccagtagacg tacgcgaacg cgccgtagaa gaacaggccc tcgatgcacg cggcgaagca
    13021 gatcaggttc agcaggaagc gacggcggtc cgccttcgtc tccagccggt cgagcttctc
    13081 caccgagtcc atccacttga agcagaactc ggccttctca cggatggacg ggatgttctc
    13141 gacggccgcg aaggccgccg cgcggtcgtc cgggtcgggg aggtaggtgt cgagcagcgt
    13201 caagtagaac tggacgtgca cggcctcctc gaagagctgg cgcgacaagt acaggcgcgc
    13261 ttccggggag ttgatgtgct tgtacagcgt cagcaccagg ttgttcgcca cgatcgagtc
    13321 gcccgtcgcg aagaacgcga ccaggcggcc gatcaggtgc tgctcaccgg gcgtcagctt
    13381 cgccaggtcg gcgacgtccg agtggaggtc gacctcctcc acggtccagg tgttcttgat
    13441 ggcgtcccgg tagcgctcgt agaagtccgg gtagcgcatc gggcgcaggg tcagctcgaa
    13501 gcccgggtcg aggagattct ggttacgggt ggacattact ggcaggcctc gcaggactcg
    13561 gggttctcaa gggagcaggc gaccgcttcg gggtcggcgg cctgctggac ggggacggtg
    13621 gcctgcgcct gggcggcgcg ggcgatgcgc gtcgcggggc gcgaacgcag gtagtacgtc
    13681 gtcttcagcc cggacttcca ggcgtaggcg tacatcgagg agagcttgcc gatggtcggc
    13741 gtctccatga acaggttcag ggactgcgcc tggtccaggt acggggtgcg ggccgccgcc
    13801 atgtcgatca ggccgcgctg cgggatctcc cacgccgtgc ggtacagccg ccgtacgtcc
    13861 tgagggatcc acgcgaagtc ctgcaccgag ccgttggact cgcgcagcgc ctcccgggtg
    13921 cgggcgtccc acacgccgag gtccttcagg tcctgcacca ggtaggagtt cacctggagg
    13981 aactcgccgg acagcgtctc gcgcttgaac aggttggaca cctgcggctc gatgcattcg
    14041 tacgcgcccg cgatcgaggc gatggtcgcg gtcggcgcga tcgccaggag cagcgagttg
    14101 cgcatgccga cccgcgcgat ccgggcccgc agcgccgccc agcgctccgg ccaggtcggc
    14161 tccacgccgt agtggtcggg gtgcagcaca ccccgggcgg tacgggtctt ctcccaggcc
    14221 ggcagcgggc cgttgcgctc ggccaggtcg gcggaggcct cgtacgcggc gagcatgatc
    14281 cgctcggcga tccgcgtgga cagggccctc gcctccggcg agtcgaacgg caggcgcagc
    14341 ttgaagaaca cgtcctgcag gcccatcgcg ccgaggccga cggggcgcca cttggcgttg
    14401 gagcggcccg cctgctcggt cgggtagaag ttgatgtcga ccacgcggtc gaggaaggtg
    14461 acggccgtgc ggaccgtggc gtccagccgc tcccagtcga tgccgccgtc ggcgacgaac
    14521 gcgccgagat tgacggagcc caggttgcag accgccgtct cgccgtcgtc ggtgacctcc
    14581 aggatctccg tgcagaggtt ggaggagtgg acgacgtggc ccggctcggc ggtctggttg
    14641 gcggtgcggt tggcggcgtc cttgaaggtc atccagccgt tgccggtctg cgccagggtg
    14701 cgcatcatcc ggccgtacag gtcgcgggcg gggatggtct tgcgggcgag gcccgccgcc
    14761 tcggccctgc ggtaggccgc gtcgaactcc tcgccccaca ggtcgaccag ttccggcacg
    14821 tcggcggggg agaacaggga ccactgcccg tcggcgttca cgcggcgcat gaactcgtcc
    14881 gggatccagt gggccaggtt caggttgtgg gtgcggcggg cgtcctcacc ggtgttgtcg
    14941 cgcagctcca ggaactcctc gatgtcggag tgccaggtct ccaggtagac cgcggcggcc
    15001 cccttgcgcc ggccgccctg gttcaccgcg gcgaccgagg cgtcgagggt cttcaggaac
    15061 gggacgatgc cgttggagtg gccgttggtg ccgcggatca gcgaaccgcg cgagcggatg
    15121 cggctgtacg acagaccgat gccgccggcg tgcttcgaga gccgggcgac ctggtggtag
    15181 cggtcgtaga tggagtccag ctcgtccttg ggggagtcca ggaggtagca ggacgacatc
    15241 tgggggtgcc gggtgcccga gttgaacagc gtgggggagg agggcaggta gtcgaggcgg
    15301 ctcatgagcg cgtagagcgc cgcgacctcg tccagggagt gcgtggtgtc gtcctcggcg
    15361 agaccggcgg cgacccgcag caggaagtgc tggggcgtct cgacgacctt gcgggtgatc
    15421 gggtggcgca gcagatagcg gctgtgcagg gtgcgcaggc cgaagtagcc gaagcggtcg
    15481 tcggcggtgc ggtcgacgag ggcgtccagg cggtcggcgt gcagccgcac gaactcggcg
    15541 gtgcggtcgg cgatcaggcc ctcgcggtgg ccgacggcga cggactcggt gaaggacgtg
    15601 acaccctgtg aggcggcctc ggcggcgatg ccgatcgcca gcaggcgggc ggccagcctg
    15661 ctgtacgcgg ggtcctcgga gatcaggccg gcggccgcct ccgtggccag ctcgcgcagc
    15721 tccgcgtcgt ccgcgtgcgc ggaccggccg cgcagcgcgg cggcggcgac ccggccgggg
    15781 tcggcgtcgg ggaggtcggc ggtcagctcg gtcagggtcc gcagcagcgc ggcaccggga
    15841 ccgtcgtcgt tcgaccgggt cgctgctgag gccggatctg cgggcgcgat ggtcacgtgg
    15901 aggctctccc tcgctgggca cgggggcctc ggtcgagggc agggggcagc tcacgagcgc
    15961 acgcggcgtc gcgtccaccg gcccattcca cgaggcccgg acgtcaggca cccggaccgg
    16021 acggccgggc gcactgtcgg caggtcctcg gactgacgct catgcgtgta tgcgggcata
    16081 cgcgcatgag tacaccgttg cgggacagtt ccggattcgc accggattcc cctgcggcga
    16141 cagcgagcat gagcatacat gttgtgccgg gtggcggtga cacccccaga tgttgtgtcc
    16201 gggtggtttc acagtgtcaa ctgaacgcag ccggcggcga cccgcgcttc gcggatcgcc
    16261 gccggctgcc gggatcaggg cgcgctcagt gggccgatcc cgccgtcgcc ggcggcagct
    16321 ccacctggac gcccgggtcg cccgcgtcgg ccgtgtagtc ctccggcttg gtctcgtcga
    16381 cgccgtcggg cgccttggcg gccctcagga cgaaggtcag gaccacggtc accacgacgt
    16441 tgagcacgaa cgccgtgagg ccgatgtagc cgatctcccc gatgcccggg atctccttcg
    16501 aggagccgcc gaagtgcttc tgcgtcggcg aggccacccc gtacgcggcg atcgtgccgt
    16561 agagcatgcc gaccgcccag ccggcgagca gcgcccagcg gtggaaccag cgcgtgaaca
    16621 ggccgccgac cagggccggg aaggtctgca ggatccagat gccgccgagg agctggaagt
    16681 tgatggcgac ggtcttgtcc atggtcagga cgaaggccag cgcgcccacc ttcaccagca
    16741 gcgacaccag cttggagacc ttcgtctcct gttcgggcgt ggcgtccttg cggatgaagt
    16801 ccttgtagat gttgcgggtg aagaggttgg ccgccgcgat ggacatgatg gccgccggca
    16861 ccagcgcgcc gatgccgatc gccgcgaacg ccacacccgc gaaccagtcc gggaacatgg
    16921 tctcgaacag ctgcgggatg gccagctggc cgttctgcac cttgatgccg gccgcgatcg
    16981 ccatgaagcc cagcagggcc agcagtccca gcatgaggga gtacagcggc aggatcgtgg
    17041 tgttgcggcg gatcacctca cggctcttcg aggagagcgt cgcggtgatc gagtgcgggt
    17101 acatgaacaa cgcgagcgcg gagcccaacg ccagcgtggc gtacgtccac tgccccgcct
    17161 ccggcgggac gaggccgccc gccccggcgc tggtgaactt ctcgtccgcc ttggcgaaga
    17221 tctcgtcgaa gccgcccagc ttgatcggga tgtagatgat cgccacggcg atgacgatgt
    17281 agatcagcgt gtccttcacg aacgcgatca gcgccggggc ccgcaggccc gaggagtagg
    17341 tgtacgcggc cagcacaccg aaggcgatca gcagcggcag gtccttgatg aaccagttgg
    17401 tgtcctcgcc gccaccgacg cccatcacgt ccagcacggc ctgtatgccg acgagctgga
    17461 gcgcgatgta cggcatggtg gcgaggatgc cggtgagggc caccgccagg gacaggccct
    17521 tcgagccgaa ccggccgcgc acgaagtccg acgtcgtcac atagccgtgc ttgtgcgaga
    17581 ccgaccacag acgcggcagg aacgtgaaga tcagcgggta cacgaggatg gtgtacggca
    17641 cggcgaagaa gccggccgcg cccgctgcgt agatcgccgc cggtacggcg acgaaggtgt
    17701 aggccgtgta gaggtcgccg ccgagcagga accaggtgat ccaggtgccg aacgaccggc
    17761 cgcccaggcc ccattcgtcg aggctgtgct cgttctcggc cttgcgccag cgcgcggcca
    17821 ggaagcccat gaccgtgacg gccaggaaga agaagatgaa gacggcgagt gcgacgccgt
    17881 tcacgccgtc cttcatcgct gctcaccgcc ccggcgggcg cgctggtcac gctgccacag
    17941 cttgaacgcg atcatcgtga gcgcggtgga gatgagcacc cacgccatct ggtaccagta
    18001 gaagaacggg atgccgatca gagccgggtc ggtcttggcg tacgagccga cccacagcat
    18061 ggccacgaac ggtgcgacaa gacagagggc gatgacgacg cgaacgggcg tcaccaccgg
    18121 ccctctgttc acttctggcg cttgagacat ctcgcgactc cgtcccctca ctgatcacct
    18181 gcgtaatggg ctggcaatct aggtcacggt gtcggccaga ggaacccctc gtccgtatat
    18241 cggtaccggc tttacaaagt cgctactcgg cggggcgctt caggcgggcc acgaacttgt
    18301 accggtcgcc ccggtagacc gaccgcaccc actccaccgg cttgccctcc cggtccaggg
    18361 agtgccggga cagcatcagc atcggcaggc ccacgtcggt gccgagcagg ccggcctcgc
    18421 gcggggtcgc cagcgaggtc tcgatggtct cctcggcctc cgcgaggtgg acgtcgtaga
    18481 cctccgcgag ggcggtgtag agggacgtgt acttggccag ggagcggcgc agtgccggga
    18541 agcgcttggc ggagagatgg gtcgtctcga tcgccatcgg ctccccgttg gccatgcgca
    18601 gccgctcgat gcgcagcacc cggccgccgg cggtgatgtc gagcaggccg gcgagccggt
    18661 cgtcggcggt gatgtagccg atgtccagca gctgcgaggt cggctccagg ccctgggcgc
    18721 gcatgtcctc cgtgtaggag gtcagctgca gcgcctggga gaccttcggc ttggcgacga
    18781 aggtgccctt gccctggatg cgctccagcc gcccttcgac caccagctcc tggagggcct
    18841 ggcgcacggt ggtgcgggag gtgtcgaact cggcggccag ggtccgctcg ggcgggaccg
    18901 gggtgcccgg cgcctgcgtc tccgtcatgt cgagcagatg cttcttcagg cggtagtact
    18961 tgggcacacg cgcggtacgg acggtcgtcc caccctcgtt ctccgcactg ctgacgtcgg
    19021 tgctcatgct ccgccttccc ggctccgtag aggtgtcgtc ggcacgctcc gtgatcccct
    19081 ctgtataccg tcgcgggcct tgttggtcta gtccaccatg cctgaagtgg tctacccgag
    19141 tatgacgggt gtagccgctg ttttcgcggg gttcttactt aaaggttcct gcatatgtag
    19201 gtcccataac ggctggtcgg gccgtacttc aggcccttga cacgcctttt ggtctgggcc
    19261 aagctccccg gtactggtct acaccattgg tccaggtccc ggccccatgg gcggtacgtc
    19321 agttcaccgc ggggagcagg ggggtttgtg gcatccctga ggagggtggc gtgaagcgca
    19381 agctgatatc cgcgatcggt gtcgcgggca tgatgatctc gctcgcggcg tgcggtggcg
    19441 acgacggcag cggcgagggc aagggcgggg cggacggcta cgcgggccag accctgacgg
    19501 tgtgggtgat ggacggctcc tcgccggacc agtggcagaa ggacgtcgcc gcggccttcg
    19561 agaagaagac caaggccaag gtcaagttcg agatccagca gtggaacggc atccagcaga
    19621 agctgaccac cgccctgtcc gaggagaacc cgccggacgt cttcgagatc ggcaacaccc
    19681 agaccccggc ctacgccaag accggcggcc tcgccgacct cgccgacctc aagaccgcga
    19741 tcggcggcga ctggaccgag tccctgaaca actcctcggt cttcgagggc aagcagtacg
    19801 cggccccctg gtacttcgcc aaccgcgtcg tcgtctacaa caagaaggtc tgggccgacg
    19861 ccggcatcaa ggacctgccg aagacccgcg acgagttcta cgccgacctc aagcagatcg
    19921 gcgagaagac cgacgccgag ccgatctacc tgcccggcca gaactggtac cacttcgtcg
    19981 gcctggtcgt cggcgagggc ggcgagctgg tcaagaagga cggcgacaag tacgtctcca
    20041 acctggacga cccgaaggtc gccgccgcca tggagaccta caagaagttc caggccctct
    20101 ccaaggcccc caaggacaag gacgaggcca ccccgcagca gggtgaggtc ttcggcaagg
    20161 gcaagaccgg cgccttcatc ggcatgggct gggaagccgg catcgccatc gaggccaacc
    20221 cggagatcga gaaggagatc ggctacttca ccatccccgg tgccacggcc gacaagcccg
    20281 agggtgtctt cctcggcggc tccaacctcg ccgtcgccgc gggcagccag aagcaggacc
    20341 tcgccaagga gttcctgaag atcgccctgt ccgacaagta cgagggccag ctggccaagc
    20401 tcaacggcgt catcccgaac aaggagtcgc tgcagggcaa cgtcaagggc aacgccgccg
    20461 ccgaggccat ggcaccggcc gccgcgggcg gtggcaccac gccgctgatc cccgagtggg
    20521 ccgcggtgga gaacgccccc aacccggtca agacctacat gaccgcggtg ctgaacggta
    20581 agtccccggc cgaggccgcc aagcaggtcg agggcgagtt caacaagcgc ctggcgcagc
    20641 agcagtaaca gcgctcgccg gggacggggg ccgcacgcgc cgcaccgccg tgcggccccc
    20701 gccccgcgac agtcgtaggt ctagagaaga gatggcgagc atgaccgtgc agaccgaacg
    20761 gccgccctcc ggcccggcgg acgtccgcaa gggggcggac gtcggaggac cgggccggcc
    20821 cacaccgaga gcgtcccgcg ccggcgcgct cggcccctac ctcctgctgc tgccggcctg
    20881 cgcggccacc gtgctgctgc tcggctggcc gctgctcaag gacgtcctgc tgtcgttcca
    20941 gaacctcaac atggcgcagc tgatccagca cgtcaccgag tggaacggcg tcgacaacta
    21001 caccgaggtc ctcaccggcg aggacttctg gcgggtcacc ctccgctcga tcctgttcac
    21061 ggcggtcaac gtcgtcctga ccatggtcct gggctccc
//
