LOCUS       NZ_LIVZ01000004        22161 bp    DNA     linear   CON 27-MAR-2024
DEFINITION  Streptomyces sp. TSRI0107 scaffold4, whole genome shotgun sequence.
ACCESSION   NZ_LIVZ01000004
VERSION     NZ_LIVZ01000004.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. TSRI0107
  ORGANISM  Streptomyces sp. TSRI0107
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 731359)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 731359)
  AUTHORS   Yan,X., Ge,H., Hindra,F., Yang,D., Huang,T., Crnovcic,I. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-AUG-2015) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2014
            Assembly Method                   :: CLC Genomics Workbench v. 7.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905845.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:50:25
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,745
            CDSs (total)                      :: 7,667
            Genes (coding)                    :: 7,467
            CDSs (with protein)               :: 7,467
            Genes (RNA)                       :: 78
            rRNAs                             :: 2, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 200
            CDSs (without protein)            :: 200
            Pseudo Genes (ambiguous residues) :: 0 of 200
            Pseudo Genes (frameshifted)       :: 85 of 200
            Pseudo Genes (incomplete)         :: 158 of 200
            Pseudo Genes (internal stop)      :: 13 of 200
            Pseudo Genes (multiple problems)  :: 51 of 200
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:19:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 501163
            Orig. end                         :: 523324
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LIVZ01000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22161
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="1"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22161
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22161
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12161](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12161
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     gene            complement(324..1532)
                     /locus_tag="AMK31_RS12700"
                     /old_locus_tag="AMK31_12570"
     CDS             complement(324..1532)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669257.1"
                     /locus_tag="AMK31_RS12700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_12570"
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_073940551.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 4.1e-08,
                     bitscore: 28.4, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRILVHDYSGHPFQAQLSRELARRGHDVVHSTCAAYVSGKGDLAA
                     DAVDGLRFVTIGDTVVLDKEAYVRRLFQETRLGFELARQVRRERPRVALLGNLPIPTLS
                     VAALMLGALRIPWVLWHQDVTAIALKSFAAAGVSRLMGVAAKVFERAEKWAARRAAAIV
                     VIAGSFLRVHREWGTDGKVTVIPNWAPLDEILPAPRDNAWSAEHGLTGVRTVLYSGTLG
                     LKHNPVLLVGLVERLREQGEQVRLVVVNDGPAVPVLKEAAAARGVPLTLLPFQPYERLP
                     EVLGTGDVLVVLLAEDAGEFSVPSKTLSYLCAGRPVLGLMPAGNPAAKLLRQASSAVFP
                     PEESALDGAARWVREVFDDPAHAEALGKESRSLAEREFALENCASRFEEILRTAIGASG
                     AGR"
     gene            complement(1560..2540)
                     /locus_tag="AMK31_RS12705"
                     /old_locus_tag="AMK31_12575"
     CDS             complement(1560..2540)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (69-204). E-value:
                     8.9e-09. Score: 26.7. Matches aSDomain:
                     nrpspksdomains_AMK31_RS12705_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003998839.1"
                     /locus_tag="AMK31_RS12705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_12575"
                     /product="NAD-dependent epimerase/dehydratase family
                     protein"
                     /protein_id="WP_073940552.1"
                     /transl_table=11
                     /translation="MSKQVDVVVAGGGGFIGGHLAADLLARGLTVRCVDIKPRHAWQQV
                     HEAAENVVADLSLLDEARAAVRDARQVYMLAADMGGMGFIENHKAACMMSVLTSTHMLK
                     AAHEAGVERYFYSSSACVYAAGKQNDPDVTALKEEDAYPAQPEDGYGWEKLFSERMCRH
                     FEEDFGFTCRVARYHNVYGPEGTWTGGREKAPAAVCRKIAEAAVSGDHRIEIWGDGRQT
                     RSFMYIDDCLRGTRLVMDGDSGVPVNVGSSELVTINQLVDIVEEIAGIRCERSYRLDAP
                     QGVRGRNSDNSLIRELYGWEPSIPLAEGLERTYAWVYDQVKLAQH"
     aSDomain        complement(1929..2333)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMK31_RS12705_NAD_binding_4.1"
                     /evalue="8.90E-09"
                     /label="AMK31_RS12705_NAD_binding_4.1"
                     /locus_tag="AMK31_RS12705"
                     /protein_end="204"
                     /protein_start="69"
                     /score="26.7"
                     /tool="antismash"
                     /translation="RQVYMLAADMGGMGFIENHKAACMMSVLTSTHMLKAAHEAGVERY
                     FYSSSACVYAAGKQNDPDVTALKEEDAYPAQPEDGYGWEKLFSERMCRHFEEDFGFTCR
                     VARYHNVYGPEGTWTGGREKAPAAVCRKIAE"
     gene            complement(2666..3370)
                     /locus_tag="AMK31_RS12710"
                     /old_locus_tag="AMK31_12580"
     CDS             complement(2666..3370)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003998840.1"
                     /locus_tag="AMK31_RS12710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_12580"
                     /product="CDP-alcohol phosphatidyltransferase family
                     protein"
                     /protein_id="WP_073940553.1"
                     /transl_table=11
                     /translation="MDFSSALRQLSEVQKPGRGVPGYARFVNRPAGRLLAAAAHRVGLS
                     PNQVTAASALVTFTAIAAIALCRPSHALGQWVCLALLLGFALDSADGQLARLHRSASVA
                     GEWVDHVVDCAKLLGVHAAVLVSFHRFFDLPAPVWLLAPLVFQFAAVVLFFAGILVEQL
                     MRRSAGARAAAADRPSVLRGMALLPVDYGLLCLLFLFVGNQELFLALYVTLLAAHVVML
                     PAFLAKWFRELS"
     gene            complement(3375..4520)
                     /locus_tag="AMK31_RS12715"
                     /old_locus_tag="AMK31_12585"
     CDS             complement(3375..4520)
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003998842.1"
                     /locus_tag="AMK31_RS12715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_12585"
                     /product="glycosyltransferase"
                     /protein_id="WP_073940554.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 3.2e-29,
                     bitscore: 97.2, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRIVHVVTLVSDDGAYGGPTSVAAGQLEECAARGHDVTLVSLWRG
                     RSLAPRRVGSVPLRTRPARSLLPGRFTGLMHPLLLGDMWRAMGRADVVHIHAGRDLVSL
                     AALAVAALRRRGFVAQTHGMVQPRRGAAVRLFDRLYVPLLRRARGCLVLTEQERRHVAE
                     VIGAGGPPLLTLPNGVRPERAGDGARRPREREVLFLARLHPRKRPDAFVEMAALVHRRV
                     PDVRFTLYGADEGVLPAVRRLIVAHGLQGVVSYGGALEHAEAVRAYGRAAVYVLPSVDE
                     PFGMTVIEALSAGTPVVCTDTCGIADELARRGAAVVTDGSPRDLADAVCDLLADEDKRV
                     ALAAAGRRAVAEAFSVHAVTDRLEDIYRRSCSARPPAMTRG"
     gene            complement(4517..5104)
                     /locus_tag="AMK31_RS12720"
                     /old_locus_tag="AMK31_12590"
     CDS             complement(4517..5104)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156: Chloramphenicol acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018382363.1"
                     /locus_tag="AMK31_RS12720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_12590"
                     /product="putative colanic acid biosynthesis
                     acetyltransferase"
                     /protein_id="WP_073940555.1"
                     /transl_table=11
                     /translation="MAETAVPPETGIRPAVPEHRAVARRSLRGFTGAGYDKGRPLLVQA
                     AWFAVLHLVFVKWWFPARWRPSVLRAFGAQVGQRVLIRHGVRVHWPWRLRVGDDVWIGE
                     GAWLLNLEQITIGSDVCVSQEALLCTGSHQRHSHTFEFDNGPIRLEPGSWVAARAVVLR
                     GVTVGRGAVVGASAVARRDVGRGEVIGSGAAV"
     misc_feature    complement(5138..5155)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 21.71"
                     /tool="antismash"
     gene            complement(5279..6604)
                     /locus_tag="AMK31_RS12725"
                     /old_locus_tag="AMK31_12595"
     CDS             complement(5279..6604)
                     /EC_number="2.7.8.-"
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Bac_transf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1146: sugar transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669260.1"
                     /locus_tag="AMK31_RS12725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_12595"
                     /product="sugar transferase"
                     /protein_id="WP_073940556.1"
                     /sec_met_domain="Bac_transf (E-value: 2.8e-68, bitscore:
                     224.3, seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLFAFGDPRPVHQAVVIGVLWVLVGIAARRYAPWTWDEGAPVGPV
                     VRDWLVLVGAWVVLRAAWGAGGAPAAVLAALCPSVLVTVVLRKGIHRHLRAVRRRAQAL
                     RRVLVVGEAATVDAVVGRLAERTDHGYVAVGACVVGEGPVLSGVRVCSRLEADASAGPE
                     GDAASVGEAVEVLGADMVFVAASGHLSGDRLRRLSWSLHDRGRPLMVLPGIVEVTRRRV
                     RLTSAAGLTLLHVKPPTRRGLSTVLKAVTDQVGALLLLVALAPLFALLAVAVRVTSPGP
                     VIYRQTRVGRNNTHFSMWKFRTMVVGADRMKGELEGVNEHDGHMFKLRQDPRTTPVGRF
                     LRRYSLDELPQLVNVLLGHMSLVGPRPPLPEEVARYDQVEMRRLSVKPGLTGLWQVSGR
                     SDLSWHETVSLDLRYVDNWSWTWDMSVMARTVRAVLDGRGAY"
     misc_feature    complement(6572..6591)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 23.58"
                     /tool="antismash"
     misc_feature    6585..6600
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.98"
                     /tool="antismash"
     misc_feature    7037..7049
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 18.7"
                     /tool="antismash"
     misc_feature    complement(7084..7098)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 19.07"
                     /tool="antismash"
     misc_feature    7090..7105
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.82"
                     /tool="antismash"
     gene            7174..7677
                     /locus_tag="AMK31_RS12730"
                     /old_locus_tag="AMK31_12600"
     CDS             7174..7677
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK31_RS12730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AMK31_12600"
                     /product="hypothetical protein"
                     /protein_id="WP_073940557.1"
                     /transl_table=11
                     /translation="MSRSAVAATRLLGVGLTTAVAVGLAAAPASAAPDVPPIFIEGNPA
                     LTCPAGGEGLRVPPTDAEYEVELENGETGVLNVDISDDGTLLTFSIDLGGEIAVRSVTV
                     KGGPNANRYVYDAANGFPNGTTGDDDLVSPLNPGGNIPEISHIDFCFIPSDYDNGNGNG
                     GGTA"
     gene            7801..8919
                     /locus_tag="AMK31_RS12735"
                     /old_locus_tag="AMK31_12605"
     CDS             7801..8919
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669249.1"
                     /locus_tag="AMK31_RS12735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_12605"
                     /product="PQQ-dependent sugar dehydrogenase"
                     /protein_id="WP_079186816.1"
                     /transl_table=11
                     /translation="MSHPGRLARQPVRVGLASLTTAAALLAVSLTQPASAAIPGAQAAA
                     DGGVPASVTKFSGAWHLPWAISFLPDGQSALVTEKHRSQVYRLGRDGTRKLIGTVPHSV
                     IGSNPSATGGLLGVAPSPTWNGTTDKRVFFMHTTATDARVVRMDYDGTSLTGYTTVLGG
                     IQWKGNHTGGKIAFGPDGYLYVTTADAWQPQLAQDKNSLNGKILRITKSGAAAPGNPFG
                     NRVYSYGHRNAQGLAWDRQGRLWSVEIGQDKYDELNLIKPGANYGWPTCEGTCTAAGMT
                     NPKRTWTPAEGTPAQLAVVRNVLYISSLRGQRLWRVSITGDTEQVGTKAAYYAGAYGRL
                     RAIAKVPGADQLWVGTSDRGTDKDNIHQVTIK"
     gene            8948..9085
                     /gene="pqqA"
                     /locus_tag="AMK31_RS12740"
                     /old_locus_tag="AMK31_12610"
     CDS             8948..9085
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712687.1"
                     /locus_tag="AMK31_RS12740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_12610"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_073940558.1"
                     /transl_table=11
                     /translation="MNESTQQTHPAEQHPAQETRTAWQTPEFTEVDTALEVTAYSLNSR
                     "
     gene            9102..10004
                     /gene="pqqB"
                     /locus_tag="AMK31_RS12745"
                     /old_locus_tag="AMK31_12615"
     CDS             9102..10004
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669247.1"
                     /locus_tag="AMK31_RS12745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_12615"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_073940559.1"
                     /transl_table=11
                     /translation="MLLLVLGTAAGGGIPQWNCACPGCSGARAHPHRRRRHASLAVRAG
                     EGRWYVVNATPDLGDQIEAHPGLHPGPGPRQTPLAGIVLTDAELDHTLGIPRLREADGL
                     QVLATAPVRQALLDRLHLGDVLTPYTSVTWRELPRRGAEPLDTETAGGLRITGIPVSGK
                     RPRYAADAPGDDAWVIALRLYDPATGGTALYAPALAAWPDHFQRAAEEADCVIVDGTFW
                     DDEEPRRTGISSRTATGMGHPPIEGPGGTAERLAHLSARCLYTHLNNTNPLVDPAAPQH
                     KRLARLGLEVAHDGMVIEL"
     gene            10001..10744
                     /gene="pqqC"
                     /locus_tag="AMK31_RS12750"
                     /old_locus_tag="AMK31_12620"
     CDS             10001..10744
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016433953.1"
                     /locus_tag="AMK31_RS12750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_12620"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_073940560.1"
                     /sec_met_domain="TIGR02111 (E-value: 6.1e-86, bitscore:
                     283.0, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTALAPRPEPSAPAEPWTPAEFEARLRAVTQERYHDRHPFNLRM
                     HSGDLTPAELRRWIANRFHYQRHIPVKDALITAKLDTSALRRMWLRRIEDHDGREEGEG
                     GIERWLRLAEAAGLDRETLLRTDDVLPGVRLAVDGYVNFCRHRPPLEAVAASLTELAAP
                     DLMRTRIDAFERHYRWIEADGLAYFRTRVDQGRRDSGEALGLVLAWARTRDGQERAVAA
                     LRFKCEVLWSLLDAVEAAGSREENP"
     gene            10741..11013
                     /gene="pqqD"
                     /locus_tag="AMK31_RS12755"
                     /old_locus_tag="AMK31_12625"
     CDS             10741..11013
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056909.1"
                     /locus_tag="AMK31_RS12755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_12625"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_073940561.1"
                     /sec_met_domain="PqqD_RRE (E-value: 6.6e-18, bitscore:
                     59.7, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.1e-10, bitscore: 37.1,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEATGSGWRPVLTPGALRRHDPVRDAVLLLLPERVGVLTGHGGE
                     IVELCDGTRSVRGIVDTLADRFPGAPVGTDVPPFLERLREEGWLR"
     aSDomain        10762..11007
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_AMK31_RS12755_PqqD_RRE.1"
                     /evalue="2.70E-19"
                     /identifier="RREFam006.1"
                     /label="AMK31_RS12755"
                     /locus_tag="AMK31_RS12755"
                     /protein_end="89"
                     /protein_start="7"
                     /score="59.7"
                     /tool="antismash"
                     /translation="GWRPVLTPGALRRHDPVRDAVLLLLPERVGVLTGHGGEIVELCDG
                     TRSVRGIVDTLADRFPGAPVGTDVPPFLERLREEGWL"
     gene            11010..12161
                     /gene="pqqE"
                     /locus_tag="AMK31_RS12760"
                     /old_locus_tag="AMK31_12630"
     CDS             11010..12161
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010357439.1"
                     /locus_tag="AMK31_RS12760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_12630"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_073940562.1"
                     /sec_met_domain="PF04055 (E-value: 2.7e-25, bitscore: 85.1,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 4.6e-08, bitscore: 28.9,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 2.6e-09, bitscore:
                     32.8, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSIDRTSPAAPTAVPARPWALLAELTHACPLHCGYCSNPLELTR
                     RSSELSAGQWTDVLRQAGELGVVHTHLSGGEPLLRPDLEHIVAAAESAGIYTQLVTSGV
                     GLDEARLAALTEAGLRSVQLSVQHADPDASDRIAVRRGSFAQKERAARLVRSAGLPLGL
                     NVVLHRENLDAVDAVVELGLAWGVDRIELANTQFYGWGLLNRDALLPTRDQLARARAAV
                     ERWRERLSAASGPDLVWVVPDYFDGVAKPCMGGWGAVSLTVSPDGTVLPCPAAAALPDL
                     DPPNVRDHPLAWIWDHSEAFTRYRGTDWMADPCRGCSRRDEDFGGCRCQAYALTGDASR
                     TDPACQLSPDHGLVRALTEDTTGGTAVPSPVPIRPRRPAQAAR"
     gene            complement(12146..13300)
                     /locus_tag="AMK31_RS12765"
                     /old_locus_tag="AMK31_12635"
     CDS             complement(12146..13300)
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1088: acyltransferase 3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009716957.1"
                     /locus_tag="AMK31_RS12765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_12635"
                     /product="acyltransferase"
                     /protein_id="WP_079186817.1"
                     /transl_table=11
                     /translation="MHGVAVVDDRPARTVPTTARNRVTAPGGRTRPRLYVLDGIRLIAA
                     LLVVLHHYAGTNRVNQPGNAIWDRPVSDIMPSWFRVASFGWIGVEIFFVISGFVICMSC
                     WGRTPKDFFVSRVIRLYPAYWFGVVFTTAVLVALPGVWERLPLREVLFNLTMLQQGSEV
                     ANVDLVYWTLWSELRFYLLFLVVVAMGLTYRRVVVFCCVWGAAAMLAPVSEFPLLVLAA
                     DPSGAWYFIAGLALYLMHRFGQDLLLWGILAMSWLMGQLELGERVAYEQVSSWRGAVVI
                     YTVFLLFMVAVALGFTDRIRWRWLVTAGALTYPLYLTHYLAGTAVINRLRDTMDARLLV
                     VCVIAGFLLLSWLVHRLVERPVARVLKRGLEASFTRLRGFQRAA"
     gene            13503..13886
                     /locus_tag="AMK31_RS12770"
                     /old_locus_tag="AMK31_12640"
     CDS             13503..13886
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015953.4"
                     /locus_tag="AMK31_RS12770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_12640"
                     /product="phage holin family protein"
                     /protein_id="WP_073940564.1"
                     /transl_table=11
                     /translation="MYKRRRLLGTYLGVAAAAALLPGITSILDSPPWEAILAGAVFLIV
                     NQLIYSYPSATRSAPPVALLLLAAFGVVQDTLLWLLVSWIGSQMDYGLHVDGFLTALLG
                     GVIVRGTVLALMALGPQPAPETS"
     gene            complement(13995..15188)
                     /gene="tuf"
                     /locus_tag="AMK31_RS12775"
                     /old_locus_tag="AMK31_12645"
     CDS             complement(13995..15188)
                     /GO_function="GO:0003746 - translation elongation factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006414 - translational elongation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="tuf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1190: GTP-binding protein LepA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004927329.1"
                     /locus_tag="AMK31_RS12775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_12645"
                     /product="elongation factor Tu"
                     /protein_id="WP_073940565.1"
                     /transl_table=11
                     /translation="MAKAKFERTKPHVNIGTIGHIDHGKTTLTAAITKVLHDAYPDLNE
                     ATPFDNIDKAPEERQRGITISIAHVEYQTEARHYAHVDCPGHADYIKNMITGAAQMDGA
                     ILVVAATDGPMPQTKEHVLLARQVGVPYIVVALNKADMVDDEEILELVELEVRELLSEY
                     EFPGDDVPVVKVSALKALEGEKEWVDSVLSLMSAVDESIPQPERDVDKPFLMPIEDVFT
                     ITGRGTVVTGRIERGVLKVNETVDIIGIKTEKTTTTVTGIEMFRKLLDEGQAGENVGLL
                     LRGIKREDVERGQVIIKPGSVTPHTEFEAQAYILSKDEGGRHTPFFNNYRPQFYFRTTD
                     VTGVVHLPEGTEMVMPGDNTEMRVELIQPVAMEEGLKFAIREGGRTVGAGQVTKIVK"
     gene            complement(15345..17471)
                     /gene="fusA"
                     /locus_tag="AMK31_RS12780"
                     /old_locus_tag="AMK31_12650"
     CDS             complement(15345..17471)
                     /GO_function="GO:0003746 - translation elongation factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006414 - translational elongation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="fusA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1190: GTP-binding protein LepA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012379465.1"
                     /locus_tag="AMK31_RS12780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_12650"
                     /product="elongation factor G"
                     /protein_id="WP_073940566.1"
                     /transl_table=11
                     /translation="MATTSLDLARVRNIGIMAHIDAGKTTTTERILFYTGVSYKIGEVH
                     DGAATMDWMEQEQERGITITSAATTCHWPLEDVDHTINIIDTPGHVDFTVEVERSLRVL
                     DGAVTVFDGVAGVEPQSETVWRQADRYGVPRICFVNKLDRTGAEFHRCVDMISDRLGAQ
                     PLVMQLPIGAEADFKGVIDLVTMKALVWSAEATKGEMYDTVDIPDTHIEAAEEYRGKLL
                     EAVAENDEELMELYLEGTEPSVEQLYAAIRRITIASGKGGGTTVTPVFCGTAFKNKGVQ
                     PLLDAVVRYLPSPVDIEAIEGHDVKDPEQVIARKPSDDEPLAALAFKIMSDPHLGKLTF
                     VRVYSGRLESGTQVLNSVKGKKERIGKIYRMHANKREEIESVGAGDIVAVMGLKQTTTG
                     ETLSDDKAPVILESMDFPAPVIQVAIEPKSKGDQEKLGVAIQRLAEEDPSFQVHSDEET
                     GQTIIGGMGELHLEVLVDRMRREFKVEANVGKPQVAYRETIRKSVEKVEFTHKKQTGGT
                     GQFARVIIAIEPIEGGDASYEFVNKVTGGRIPKEYIPSVDAGAQEAMQFGILAGYEMTG
                     VRVTLLDGAYHEVDSSELAFKIAGSQAFKEAARKASPVLLEPMMAVEVTTPEDYMGEVI
                     GDINSRRGQIQAMEERAGARVVKGLVPLSEMFGYVGDLRSKTSGRASYSMQFDSYAEVP
                     RNVAEEIIAKAKGE"
     gene            complement(17511..17981)
                     /gene="rpsG"
                     /locus_tag="AMK31_RS12785"
                     /old_locus_tag="AMK31_12655"
     CDS             complement(17511..17981)
                     /GO_component="GO:0000314 - organellar small ribosomal
                     subunit [Evidence IEA]"
                     /GO_component="GO:0022627 - cytosolic small ribosomal
                     subunit [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rpsG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013054923.1"
                     /locus_tag="AMK31_RS12785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_12655"
                     /product="30S ribosomal protein S7"
                     /protein_id="WP_003998848.1"
                     /transl_table=11
                     /translation="MPRKGPAPKRPVIIDPVYGSPLVTSLINKVLLNGKRSTAERIVYG
                     AMEGLREKTGNDPVITLKRALENIKPTLEVKSRRVGGATYQVPVEVKPGRANTLALRWL
                     VGYSRARREKTMTERLLNELLDASNGLGAAVKKREDTHKMAESNKAFAHYRW"
     gene            complement(17984..18355)
                     /gene="rpsL"
                     /locus_tag="AMK31_RS12790"
                     /old_locus_tag="AMK31_12660"
     CDS             complement(17984..18355)
                     /GO_component="GO:0000314 - organellar small ribosomal
                     subunit [Evidence IEA]"
                     /GO_component="GO:0022627 - cytosolic small ribosomal
                     subunit [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rpsL"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020488528.1"
                     /locus_tag="AMK31_RS12790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_12660"
                     /product="30S ribosomal protein S12"
                     /protein_id="WP_003948652.1"
                     /transl_table=11
                     /translation="MPTIQQLVRKGRQDKVEKNKTPALEGSPQRRGVCTRVFTTTPKKP
                     NSALRKVARVRLTSGIEVTAYIPGEGHNLQEHSIVLVRGGRVKDLPGVRYKIIRGSLDT
                     QGVKNRKQARSRYGAKKEK"
     gene            18736..19485
                     /locus_tag="AMK31_RS12795"
                     /old_locus_tag="AMK31_12665"
     CDS             18736..19485
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0030552 - cAMP binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1133:
                     Transcription regulator, crp"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010354277.1"
                     /locus_tag="AMK31_RS12795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK31_12665"
                     /product="Crp/Fnr family transcriptional regulator"
                     /protein_id="WP_073940567.1"
                     /transl_table=11
                     /translation="MTIGTYAPDDGGLDDRVPFLARLESEDRSALLALGRTLSFTRRTI
                     LLHQHEPSSHVLFLVDGWTKVTASAANGYEALLALRGPGDIIGESAALTGRPRSATVTA
                     LEPVRAVALERERFRDFLGRSPAVSFALLGLTADRTRAADRRRLEFASMSVRERLAVLL
                     LELARTHGRRTPDGVELAVPLSKQELAGSVGASREMVQRLLKELRDKEAVITGRRTLLI
                     RRPDVLRRIGATAPAPGIPAPPGPREE"
     misc_feature    19509..19524
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.67"
                     /tool="antismash"
     gene            19611..>20180
                     /locus_tag="AMK31_RS42305"
                     /pseudo=""
     CDS             19611..>20180
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018101250.1"
                     /locus_tag="AMK31_RS42305"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSDPVSRTILLLDIERFSDRDDVEQAYLRRMLYDITDRTLERAGI
                     DETRRLRADRGDSVMELIDANAPVTALLRALLTEVPAQLRAVNRMASRSAQIRLRGVVA
                     SGWVAVDDRDGWVGSDLNHACRLLDADVLRAALRERADDFALCVSDGLYAGVVRHDHPG
                     IPADGFHAVTVASKNGPLTAWLHGPLP"
     misc_feature    20686..20701
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.14"
                     /tool="antismash"
     misc_feature    21841..21855
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.17"
                     /tool="antismash"
ORIGIN
        1 cgagcccgag ttcggtcagg accacggcgg ccagggcggt ggaatcgctg gtgcggtagc
       61 cgaggggata ggtgtcggtc gcgagcatgg cgagcggcgc caggccgagc cacacatagg
      121 tgaagagcca gaacccgaag gcgacgagtc gcaccgacgt ggcggtgagc acccgggcca
      181 gcgccgcacc cgtgtgcacc acgacgacgc actgcacggc gacagccgcc ccgaaccgga
      241 catgaggggt cagcaggacc agcccgggca gcagcccgac gagcacgacg gtccagcagc
      301 acaccgctgc gaccgaacgc tccttaccgt cccgcaccgg acgccccgat cgccgttctc
      361 aggatctcct cgaaccgcga ggcgcagttc tccagagcga actcccgctc ggccagcgac
      421 cggctttcct tccccagtgc ctcggcgtgc gccgggtcgt cgaacacctc gcgaacccag
      481 cgggccgcgc cgtccagcgc ggactcctcc ggcgggaaca ccgccgagct ggcctggcgg
      541 agcagtttgg ccgccgggtt gcccgccggc atcagcccca gcaccgggcg cccggcgcac
      601 aagtaggaca gcgtcttgga cggcaccgag aactctccgg cgtcctccgc cagcagcacg
      661 accagcacgt cacccgtgcc gagcacctcg ggcagccgct cgtagggctg gaagggcagc
      721 agggtcaggg ggacgccccg ggcggcggcc gcctccttca gcacggggac ggccgggccg
      781 tcgttgacca cgaccaggcg gacctgctcg ccctgctccc gcagccgctc gaccagcccc
      841 accagcagga cggggttgtg cttgaggccg agggtgcccg agtacagcac ggtccggacg
      901 ccggtgaggc cgtgctccgc cgaccacgcg ttgtcgcggg gggcgggcag gatctcgtcc
      961 agcggggccc agttggggat gacggtgacc ttgccgtcgg tgccccactc cctgtgcacc
     1021 cgcaggaagg agccggcgat caccacgatc gccgccgccc gtcgcgccgc ccacttctcg
     1081 gcccgttcga agaccttggc ggcgacgccc atcagcctgg agactccggc ggcggcgaag
     1141 ctcttgagcg cgatggcggt gacgtcctgg tgccacagca cccacgggat gcgcagcgcc
     1201 ccgagcatca gcgcggccac ggacagcgtc gggatcggca ggttgccgag cagcgccacc
     1261 cgcggtctct cgcgccgtac ctgccgggcg agttcgaagc cgagccgggt ctcctggaag
     1321 aggcgccgga cgtacgcctc cttgtccagc acgacggtgt ctccgatggt gacgaagcgc
     1381 aggccgtcga ccgcgtctgc ggcgaggtcg cccttcccgg agacgtaggc ggcgcaggtg
     1441 gaatgcacca cgtcgtggcc gcggcgtgcc agctcgcggc tgagctgcgc ctggaacggg
     1501 tgtccgctgt agtcgtggac gaggatcctc atcggctgct ctcccggcct ggccgtcgat
     1561 cagtgctggg cgagcttcac ctggtcgtac acccaggcgt acgtcctctc cagcccttcg
     1621 gccagcggga tcgacggctc ccagccgtag agttcccgga tcaggctgtt gtcggagttg
     1681 cggccccgca cgccctgggg ggcgtccagc cggtacgagc gctcgcagcg gatgcccgcg
     1741 atctcctcga cgatgtcgac cagttggttg atggtgacga gctccgagga gccgacgttg
     1801 accgggacgc cgctgtctcc gtccatgacc agccgcgtgc cccgcaggca gtcgtcgatg
     1861 tacatgaagg agcgggtctg ccggccgtcg ccccagatct cgatccggtg atcaccggag
     1921 acagcggcct cggcgatctt gcggcacacg gctgccgggg ccttctcgcg gcctccggtc
     1981 caggtgccct cggggccgta gacgttgtgg tagcgcgcga cgcggcaggt gaacccgaag
     2041 tcctcctcga agtgccggca catgcgctcg gagaacagct tctcccagcc gtagccgtcc
     2101 tcgggctggg ccgggtacgc gtcctcctcc ttcaacgcgg tgacgtcggg gtcgttctgc
     2161 ttgccggctg cgtacacgca ggcggaggag gagtagaagt agcgctccac gccggcctcg
     2221 tgcgccgcct tcagcatgtg ggtgctggtc agcaccgaca tcatgcaggc ggccttgtgg
     2281 ttctcgatga agcccatgcc gcccatgtcg gcggcgagca tgtacacctg gcgggcgtca
     2341 cggacggcgg cgcgggcctc gtcgagcagc gacaggtcgg cgacgacgtt ctcggcggcc
     2401 tcgtgcacct gctgccacgc atgccggggc ttgatgtcga cgcagcggac ggtcagcccc
     2461 cgggccagga ggtcggccgc gaggtggcca ccgatgaatc ctccgcctcc ggcgacgacg
     2521 acatccacct gcttgctcat ggcagctcct tgagagaccc gggatctgcc aggcaggtta
     2581 gtcactgttt gtccggttta ttgccaattg gcgcgcgccc tcgtgtcccg ttgcgcacga
     2641 tgcccccatc cgagtgcccg tcccgtcacg acagctcccg gaaccacttg gcgagaaacg
     2701 ccggcagcat gacgacgtgc gccgcgagca gggtgacgta cagcgcgagg aagagctcct
     2761 ggttccccac gaacaggaag agcaggcaca gcaggccgta gtccaccggt agcagtgcca
     2821 tgccgcgcag caccgagggc cggtccgccg cggcagcccg tgccccggcg gaccgcctca
     2881 tcagctgctc caccagaatg cccgcgaaga acaacaccac ggccgcgaac tgaaagacga
     2941 gcggggccag cagccacaca ggagccggca ggtcgaagaa gcggtggaac gagaccagga
     3001 cagccgcgtg gacgcccagc agcttcgcgc agtcgaccac gtggtccacc cattcaccgg
     3061 ccacgctggc cgaccggtgc agccgggcca gctggccgtc cgccgagtcg agcgcgaagc
     3121 cgagcagcag ggcgaggcag acccactggc cgagcgcgtg cgagggccgg cacagggcga
     3181 tcgccgcgat ggccgtgaag gtgaccaggg cgctggcggc ggtcacctgg ttgggcgaca
     3241 gcccgacacg gtgcgccgcc gccgcgagca gcctgcccgc cggccggttg acgaaccgtg
     3301 cgtaaccggg gacgccccgg ccgggtttct gcacctctga gagctgccgc agggcactgg
     3361 agaagtccat gctctcaacc tcgtgtcatc gcgggcgggc gggcgctgca cgaccgccgg
     3421 tagatgtcct ccagccggtc cgtcaccgcg tggacggaga acgcctccgc tacggcgcgc
     3481 cgtcccgccg cggcgagcgc gacccgcttg tcctcgtcgg ccagcaggtc gcacaccgcg
     3541 tcggccagat cccgggggct gccgtcggtg accaccgccg ccccccggcg agccagctcg
     3601 tcggcgatgc cgcaggtgtc ggtgcacacc acgggggtgc ccgcggagag cgcctcgatc
     3661 acggtcatcc cgaacggctc gtcgacgctg ggcagcacgt agacggccgc cctcccgtag
     3721 gcccgtaccg cctccgcgtg ctccagcgcc ccgccgtagg agacgacgcc ctgcagcccg
     3781 tgggcgacga tgagccggcg caccgcgggc agcacgccct cgtccgcccc gtacagggtg
     3841 aaccggacgt cgggcaccct ccggtgcacc agcgcggcca tctcgacgaa cgcgtccggg
     3901 cgcttgcgcg ggtggagccg ggcgaggaag agcacctccc gctccctcgg ccgcctcgca
     3961 ccgtcccccg cccgctccgg ccgcaccccg ttgggcaggg tcagcagcgg cggaccgccg
     4021 gcgccgatga cctcggccac gtgccggcgc tcctgctccg tgaggaccag gcagccgcgc
     4081 gcccgtcgca gcagaggtac gtacagacgg tcgaagagcc ggacggcggc gccgcgccgg
     4141 ggctgcacca ttccgtgcgt ctgcgcgacg aacccccggc gccgcaacgc cgccacggcc
     4201 agcgccgcga gggacaccag gtcacgcccc gcgtggatgt gcaccacgtc ggccctgccc
     4261 atggcacgcc acatgtcccc gagaagcagc gggtgcatga gcccggtgaa ccgccccggg
     4321 agcagggatc gcgcggggcg cgtccgcagc ggcacggagc cgacgcggcg cggcgccagg
     4381 gacctgcccc gccacaagga caccaaggtg acgtcgtggc cgcgcgccgc gcactcctcc
     4441 aactgcccgg cggccacgct ggtgggtccg ccgtacgccc cgtcgtcgct gaccagcgtc
     4501 accacgtgca cgatcctcat acggcggctc cggaaccgat gacctcgccc cggccgacgt
     4561 cgcggcgggc gaccgccgag gcgcccacca ccgcaccgcg gccgacggtg acaccgcgca
     4621 gcacgaccgc acgcgccgcc acccaggagc ccggctccag gcggatgggc ccgttgtcga
     4681 actcgaaggt gtgactgtgg cgttggtggc tgcccgtgca cagcagcgcc tcctgggaga
     4741 cgcacacgtc gctgccgatc gtgatctgct ccaggttcag cagccaggcg ccctcgccga
     4801 tccagacgtc gtcaccgaca cgcagccgcc acggccagtg cacgcggacc ccgtgacgga
     4861 tgagcacccg ctgtccgacc tgcgcgccga acgcccgcag caccgagggc cgccagcggg
     4921 ccgggaacca ccatttgacg aagacgagat ggagtacggc gaaccaggcc gcctggacga
     4981 gcagcgggcg ccccttgtcg tagccggctc cggtgaagcc ccgcagggaa cgccgcgcga
     5041 ccgcccggtg ctccggcacg gccgggcgga ttccggtctc tggtggcact gcggtctctg
     5101 ccatggcgat ggcccttccc cgactggacg gtatgcctat cggcacaagg tgctatgaac
     5161 cggtgatccg agccaccaca taccggtgtg tcgcggacag actcgaccgc acggatcagc
     5221 gccgcccgat cggcggcggg gcggctcccg gtggcggggc ggctccgatg gcgggcgttc
     5281 agtaggcccc gcgtccgtcc agcacggcgc ggaccgtgcg ggccatgacg gacatgtccc
     5341 atgtccacga ccagttgtcg acgtagcgca ggtcgagcga gacggtctcg tgccaggaca
     5401 ggtcggaccg tccgctcacc tgccacagtc ccgtgaggcc gggcttcacg ctcagccggc
     5461 gcatctccac ctggtcgtac cgggcgactt cctcggggag cgggggccgg ggccccacca
     5521 gggacatgtg tccgagcagg acgttgacca gctggggaag ctcgtccagc gaatagcggc
     5581 gcaggaagcg gccgacaggg gtggtacgcg ggtcctggcg gagcttgaac atgtggccgt
     5641 cgtgctcgtt caccccctcc agctcaccct tcatccggtc ggcccccacg accatggtcc
     5701 ggaacttcca catggagaag tgggtgttgt tccgccccac tcgcgtctgg cggtagatga
     5761 cggggccggg cgaggtgacg cgcacggcga ccgcgaggag cgcgaacagc ggagccagcg
     5821 cgacgagcag gagaagcgcg ccaacctgat ccgtcacggc cttcaggacc gtggacaggc
     5881 cgcgccgcgt cggcggtttc acgtgcagca gggtgagccc ggccgctgag gtgagccgga
     5941 cccggcgccg ggtcacctcg acgatgcccg gcaggaccat cagcgggcgg ccccggtcgt
     6001 gcaacgacca ggacagccgc cgcagccggt ccccggacag gtgtccgctc gccgccacga
     6061 agaccatgtc ggcgccgagc acctcgaccg cctcgcccac cgacgcggcg tcgccctcgg
     6121 ggccggccga cgcgtccgcc tccagccggg aacacacgcg tacgccggac agcaccgggc
     6181 cctcgccgac cacacaggcg ccgaccgcca cgtacccgtg gtcggtgcgc tcggcgagcc
     6241 gcccgaccac ggcgtcgacg gtcgcggcct caccgacgac cagcacccgg cgcagcgcct
     6301 gcgcgcgtcg gcggacggcg cgcagatggc ggtggatccc cttgcggagg acgacggtga
     6361 cgagcaccga gggacacagt gccgcgagga cggcggcggg cgcgccaccg gccccccagg
     6421 cggcgcgcag cacgacccag gccccgacga gcaccagcca gtcccgcacg accggcccga
     6481 ccggggcgcc ctcgtcccag gtccacggcg cgtaccggcg cgcggcgatg cccacgagca
     6541 cccagaggac gccgatcacc accgcctggt gcacggggcg ggggtccccg aaggcgaaca
     6601 gcatggccgc cgcggggaca gccgccccgg cggcgtcgac agcgacggtg gcgggcagac
     6661 accgtccaac cccactgctg ttgaacgaag ttgccctggg cggcgccaga gtcgccgcct
     6721 gccgtgatgc cgcgctgatg gactgccgca tggctctccc tgggaccccg tggaagacgt
     6781 agggcgcggc tgcaacggca cgggcagagc agcgcgcacg cctgatgtga tcgttatatc
     6841 aacgttccac cccttacgcc ctatttacat gctgtataga tgagcgcggc caccggcacg
     6901 cagggcacct catcaggggc cgcgaccccg cgaccggccc gtcgccaaag cgccgcgaca
     6961 tgagggcagt tcaccttgtc agccgaattg cggctcgtat ggcgtaaggg cgagatgtcg
     7021 cgaggtgtgt cagcgatcgg attatgcaaa tgttgcatcg cccggtggcg gacagaggtt
     7081 ccattctcga attgccaatg gaaacggcgc gagtgtccgc gggggcaaac caaaaaacta
     7141 ggaggaatac tcgtcatgcg agtagctacc cgtatgtcgc gctcggcagt ggccgcgacg
     7201 cgtcttctcg gcgtcggcct caccacggcc gtggccgtcg gtctcgccgc cgcccccgcc
     7261 tcggccgcgc cggacgtccc ccccatcttc atcgagggca acccggcgct gacgtgcccc
     7321 gccggcggcg aaggcctgag ggtccccccc accgacgcgg agtacgaggt cgagctcgag
     7381 aacggcgaga ccggcgtgct caacgtcgac atcagcgacg acggcaccct gctcaccttc
     7441 agcatcgacc tcggtggcga gatcgccgtc cgcagcgtca ccgtcaaggg cggccccaac
     7501 gccaaccgct acgtctacga cgcggcgaac ggcttcccga acggcaccac gggcgacgac
     7561 gacctcgtgt ccccgctgaa cccgggcggc aacatccccg agatcagcca catcgacttc
     7621 tgcttcatcc cgagcgacta cgacaacggc aacggtaacg gcggcggcac cgcctgacgc
     7681 gccgctgcgg tgaatgagtg agggggcccg gaaaaccggg ccccctcgcc atttccccga
     7741 gcgcgaaacc gaatttcgcg cgtattcacc cagccagaat cagcgtagaa gggtgtcgac
     7801 atgtcacatc caggccgcct cgcgcggcaa ccggtccgcg tgggcctggc ctcactcacc
     7861 actgctgccg ccctccttgc cgtcagcctc acacaacccg cttcggcggc catcccgggc
     7921 gcacaggccg ccgccgacgg cggcgtaccg gcctccgtca ccaagttctc cggcgcgtgg
     7981 cacttgccct gggcgatctc gttcctgccg gacgggcagt ccgcgctggt gaccgagaaa
     8041 cacagatccc aggtgtaccg gctcggccgg gacggcacca ggaaactgat cggcaccgtg
     8101 ccccactcgg tcatcggttc caatccgagc gccaccggcg ggctgctcgg cgtggccccg
     8161 tcgccgacct ggaacggcac gacggacaag cgcgtgttct tcatgcacac cacggccacg
     8221 gacgcccgcg tcgtccgcat ggactacgac ggcacgtcgc tgaccggcta caccacggtc
     8281 ctcggcggca tccagtggaa gggcaaccac accggaggca agatcgcctt cggccccgac
     8341 gggtacctct acgtgacgac cgccgacgcc tggcagccgc agctggcgca ggacaagaac
     8401 tccctgaacg ggaagatcct tcgcatcacc aagtccggcg ccgccgcccc cggcaacccg
     8461 ttcggcaacc gggtctacag ctacgggcac cgcaacgcgc agggcctggc ctgggaccgc
     8521 cagggcaggc tgtggtcggt ggagatcggc caggacaagt acgacgaact gaacctgatc
     8581 aagcccggcg ccaactacgg ctggcccacc tgcgagggca cctgcaccgc ggcgggtatg
     8641 accaacccca agcgcacctg gacaccggcg gagggcacac ccgcccaact cgccgtcgta
     8701 cgcaacgttc tgtacatctc gtcgctgcgc ggccagcggc tgtggcgggt ctcgatcacc
     8761 ggggacaccg agcaggtcgg cacgaaggcc gcctactacg ccggcgcgta cggccggctg
     8821 cgcgccatcg ccaaggtccc gggcgccgac caactgtggg tcggcaccag cgaccgagga
     8881 accgacaagg acaacatcca ccaagtcacc atcaagtgac ccccataccg agaagggcac
     8941 acgagacatg aacgagagca cgcagcagac gcatccggcc gagcagcacc ccgcgcagga
     9001 gacgaggacc gcctggcaga cccctgagtt caccgaagtc gacaccgccc tcgaagtgac
     9061 cgcctactcc ctcaactccc gctgaccgaa gagccgaagc catgctgctg ctggtactcg
     9121 gcaccgccgc cggcggcggg atcccccagt ggaactgtgc gtgtcccgga tgctccgggg
     9181 cacgcgcgca tccacaccgc cgccgccgtc acgcctcgct cgccgtccgc gcgggggaag
     9241 gccgctggta cgtcgtcaac gccacccccg acctcggcga ccagatcgag gcccaccccg
     9301 gactgcaccc gggccccggc ccccggcaga cgccgctcgc cggaatcgtc ctcaccgacg
     9361 ccgaactcga ccacaccctc ggcatccccc gtctgcgcga ggcggacggc ctccaggtgc
     9421 tcgcgacggc ccccgtccgc caggccctcc tggaccgcct gcacctcggc gacgtactca
     9481 cgccgtacac ctccgtgacc tggcgggagc tgccccggcg cggtgccgag ccgctggata
     9541 cggagacggc cgggggcctg cggatcaccg gcatcccggt gtcgggcaag cgcccccggt
     9601 acgccgccga cgcgcccggc gacgacgcct gggtgatcgc cctgcgcctg tacgaccccg
     9661 ccaccggcgg caccgcgctc tacgcgccgg cgctcgccgc ctggccggac cacttccagc
     9721 gggccgccga ggaggccgac tgcgtcatcg tcgacggcac cttctgggac gacgaggagc
     9781 cccgccgcac cggcatctcc tcgcgcaccg ccaccggcat gggccatccg cccatcgagg
     9841 ggccgggcgg caccgccgag cgcctcgcgc acctctccgc ccgctgcctc tacacgcacc
     9901 tcaacaacac caaccccctc gtcgacccgg cggcacccca gcacaagcgg ctcgcccggc
     9961 tgggtctcga ggtggcacac gacggaatgg tgatcgagct gtgaccacgg cactcgcccc
    10021 acgccccgag ccctccgccc ccgccgagcc ctggactccc gcagagttcg aggcacggct
    10081 gcgcgcggtc acccaggagc ggtaccacga ccgccacccc ttcaacctcc gtatgcacag
    10141 cggcgatctc accccggccg agctgcgccg ctggatcgcc aaccgcttcc actaccagcg
    10201 ccacatcccc gtcaaggacg cgctgatcac cgccaagctg gacacttccg cgctgcgccg
    10261 gatgtggctg cgccgcatcg aggaccacga cggccgggaa gagggcgagg gcggcatcga
    10321 acggtggctg cggctcgccg aggcggccgg cctggaccgc gagacgctgc tccgcacgga
    10381 cgacgtactc cccggcgtac gactcgcggt cgacggatac gtcaacttct gccggcaccg
    10441 cccgcccctc gaagccgtcg ccgcctcgct caccgaactc gccgcccccg atctgatgcg
    10501 cacccgcatc gacgccttcg agcgccacta ccggtggatc gaggccgacg gcctcgccta
    10561 cttccgcacc cgggtcgacc agggccggcg cgacagcggc gaggcgctcg gcctcgtact
    10621 cgcctgggcc cgcacccggg acggccagga acgcgccgta gccgccctgc gcttcaagtg
    10681 cgaggtcctg tggtcgctgc tggacgcggt ggaggcggcg ggcagccgcg aggagaaccc
    10741 gtgaccgagg cgaccgggag cggctggcgc cccgtcctca ccccgggcgc gctgcgccgc
    10801 cacgaccccg tccgcgacgc cgtcctgctc ctcctccccg agcgcgtcgg cgtcctgacc
    10861 ggtcacggcg gggagatcgt cgagctgtgc gacggcaccc ggagtgtgcg cgggatcgtc
    10921 gacacgctgg ccgaccggtt tcccggcgcc ccggtcggca ccgacgtacc cccgttcctg
    10981 gagcggctgc gcgaggaggg ctggctcaga tgaccagcat cgaccggacg agccccgccg
    11041 cgccgacggc cgtgcccgcc cgcccctggg ccctgctcgc cgaactcacc cacgcctgcc
    11101 ccctgcactg cggctactgc tccaacccgc tggagctgac ccggcgttcg agcgagctga
    11161 gcgccgggca gtggacggac gtgctgcgcc aggccggcga gctcggagtc gtccacacgc
    11221 atctctccgg cggcgagccg ctgctccgcc cggacctgga gcacatcgtc gccgccgccg
    11281 agagcgccgg gatctacacc cagctggtca ccagcggtgt cggcctcgac gaagcccggc
    11341 tggccgcgct caccgaggcc ggtctgcgca gtgtccagct gtccgtccag cacgcggacc
    11401 cggacgcctc ggaccgcatc gccgtacgcc ggggctcctt cgcgcagaag gaacgggccg
    11461 cccggctggt acggtctgcc ggtctcccgc tcggcctcaa cgtcgtcctg caccgcgaga
    11521 acctggacgc cgtcgacgcc gtcgtcgagc tggggctggc ctggggtgtg gaccggatcg
    11581 aactggccaa cacccagttc tacggctggg gcctgctcaa ccgggacgcg ctgctgccca
    11641 cgcgcgacca gctcgcccgc gcgcgggccg ccgtggagcg gtggcgggaa cggctgtccg
    11701 ccgcctccgg acccgacctg gtctgggtcg tccccgacta cttcgacggc gtcgccaagc
    11761 cgtgcatggg gggttggggc gcggtctcgc tcaccgtctc ccccgacggc accgtcctgc
    11821 cctgcccggc cgccgccgcg ctgccggacc tcgacccgcc gaacgtccgt gaccacccgc
    11881 tggcctggat ctgggaccac tccgaggcgt tcacccgcta tcgcggcacc gactggatgg
    11941 ccgacccgtg ccgcggctgt tcccgccgcg acgaggactt cggcggctgc cgctgccagg
    12001 cctacgccct gaccggagac gcctcccgta cggaccccgc ctgccagctc tcccccgacc
    12061 acggcctggt gcgggcactg accgaggaca ccaccggcgg tacggccgtc ccctcccccg
    12121 tgccgatcag accgcgcaga cccgctcagg ccgcccgctg aaacccccgc aaccgcgtga
    12181 acgacgcctc cagcccccgc ttcagcacac gcgccaccgg ccgttccacc agccggtgca
    12241 ccagccagct cagcagcagg aacccggcga tcacgcagac caccagcagc cgcgcgtcca
    12301 tcgtgtcccg cagacggttg atgaccgccg taccggcgag gtagtgcgtc agatacagcg
    12361 gatacgtcag cgcgcccgcc gtcaccagcc accgccaccg gatccggtcc gtgaagccca
    12421 gcgccacggc gaccatgaac agcaggaaca cggtgtagat caccaccgcg ccgcgccagc
    12481 tgctgacctg ctcgtacgcc acccgctcgc ccagctccag ctggcccatc agccaggaca
    12541 tggcgagtat gccccagagc agcaggtcct ggccgaagcg gtgcatcagg tagagggcga
    12601 ggccggcgat gaagtaccag gcgccgctcg ggtcggcggc cagcacgagg agcgggaact
    12661 cggacaccgg cgcgagcatg gcggccgcgc cccagacgca gcagaacacc acgacccgcc
    12721 ggtaggtcag gcccatggcg acgacgacca ggaacagcag gtagaagcgc agctcggacc
    12781 agagggtcca gtagacgagg tcgacattgg caacctcgga gccctgctgg agcatcgtca
    12841 ggttgaacag cacctcgcgc agcgggagcc gctcccacac gcccgggagg gccaccagga
    12901 cagcggtggt gaagacgacc ccgaaccagt acgccgggta caggcggatc acccgcgaga
    12961 cgaagaagtc cttcggggtg cggccccagc aggacatgca gatgacgaag ccgctgatga
    13021 cgaagaagat ctcaacgccg atccagccga acgacgccac ccggaaccag ctcggcatga
    13081 tgtcggacac cggccggtcc cagatcgcgt tgcccggctg gttcacccgg ttcgtgcccg
    13141 cgtagtggtg cagtaccacc agcagggcgg cgatcaggcg gatgccgtcg aggacgtaca
    13201 ggcggggacg ggtccggccg ccgggtgctg tgacccgatt ccgcgcggtc gtgggcaccg
    13261 tccgtgccgg ccgatcgtcg acgactgcaa ccccgtgcat cagaaaaccc cagcaaccct
    13321 cgtgtcgtat gccgacggct cacgctacga ccgcacgatc cgcccccacg aggacagaaa
    13381 gaacaatccc cccacacggt cacggaagtt gacggaactc ttcccaaccc gccgcggaag
    13441 gttcgctcag gtttcatccc ggggccttgt cagcggcggc ggcgccccct catgatccgg
    13501 ccatgtacaa gcgaagacgc cttctgggca cctatctggg agttgccgca gccgccgcgc
    13561 tgctccccgg catcacctcg atactcgaca gcccgccatg ggaagcgatc ctggccggcg
    13621 ccgtcttcct catcgtcaac cagctgatct acagctatcc cagcgccacc cgcagcgccc
    13681 cgccggtcgc gctgctgctc ctcgccgcgt tcggcgtcgt ccaggacacg ctgctgtggc
    13741 tgctggtctc ctggatcggc tcccaaatgg actacggcct ccatgtggac ggcttcctca
    13801 ccgccctgct cggcggcgtc atcgtccgcg ggaccgtcct ggccctgatg gccctgggac
    13861 cccagcccgc gccggaaacc tcgtaacacc tcgcagccca tgacaaaggg gcccgtacga
    13921 ccgaagtcgt acgggcccct tcaggagctc gcggctggag ctaccgggtc acaggaccct
    13981 caagcaagcg ggacttactt gacgatcttg gtgacctggc cggcgccgac ggtccggcca
    14041 ccctcacgga tggcgaactt caggccctcc tccatggcga cgggctggat cagctcgacg
    14101 cgcatctcgg tgttgtcgcc cggcatgacc atctcggtgc cctcggggag gtgcacgacg
    14161 ccggtcacgt ccgtggtacg gaagtagaac tgcgggcggt agttgttgaa gaacggggtg
    14221 tggcggccac cctcgtcctt cgacaggatg taggcctggg cctcgaactc ggtgtgcggg
    14281 gtgaccgaac ccggcttgat gatgacctgg ccgcgctcga cgtcctcgcg cttgatgccg
    14341 cggaggagca gaccgacgtt ctcaccggcc tggccctcgt cgagcagctt gcggaacatc
    14401 tcgataccgg tgaccgtggt ggtggtcttc tcggtcttga tgccgatgat gtcgacggtc
    14461 tcgttgacct tcaggacacc acgctcgata cggccggtga cgaccgtacc gcgaccggtg
    14521 atcgtgaaga cgtcctcgat cggcatgagg aacggcttgt cgacgtcgcg ctccggctgc
    14581 gggatcgact cgtcgacagc gctcatcagg ctgaggacgg agtccaccca ctccttctcg
    14641 ccctcgaggg ccttcagagc ggagaccttg acgaccggaa cgtcgtcgcc cgggaactcg
    14701 tactcggaga ggagctcacg gacctcgagc tcgacgagct ccaggatctc ctcgtcgtcc
    14761 accatgtcgg ccttgttcag ggcgacgacg atgtacggaa cgccgacctg gcgggccagg
    14821 agcacgtgct ccttggtctg cggcatcggg ccgtcggtgg cggcgaccac gaggatggcg
    14881 ccgtccatct gcgccgcacc cgtgatcatg ttcttgatgt agtccgcgtg acccgggcag
    14941 tcgacgtggg cgtagtgacg cgcctcggtc tggtactcga cgtgcgcgat ggagatggtg
    15001 ataccgcgct gacgctcttc cggcgccttg tcgatgttgt cgaacggggt ggcctcgttc
    15061 aggtccgggt acgcgtcgtg cagcaccttg gtaatggcgg ccgtgagggt cgtcttaccg
    15121 tggtcgatgt gaccgatggt gccgatgttg acgtgcggct tagtccgctc gaacttcgcc
    15181 ttcgccactg gggtcctcct gtggagtggt tctgtacgcc ttacttcatc ggcgccaggt
    15241 gatctttgct ggatggcccg gatcccgggg gcaaacatcc gtgattgcgg ttgtttgccc
    15301 cacgaggctc cggagtcaag cctacggcgt ggacgcgagg tccgttactc gcccttggcc
    15361 ttcgcgatga tctcctcggc gacgttccgc ggaacctcgg cgtaggagtc gaactgcatg
    15421 gagtagctgg cgcggccgga cgtcttgctg cgcaggtcgc cgacgtaacc gaacatctcc
    15481 gaaaggggca cgaggccctt cacgacgcgg gcaccggccc gctcctccat ggcctggatc
    15541 tgaccacggc gggagttgat gtcgccgatg acctcaccca tgtagtcctc gggcgtggtg
    15601 acctcgacgg ccatcatcgg ctcgagcagc acggggctgg ccttgcgcgc ggcctccttg
    15661 aaggcctgcg aaccggcgat cttgaacgcg agctcggagg agtccacctc gtggtaggca
    15721 ccgtcgagca gcgtgacgcg cacaccggtc atctcgtaac cggcgaggat gccgaactgc
    15781 atggcctcct gcgcaccggc gtcgaccgaa gggatgtact ccttcgggat gcggccacca
    15841 gtcaccttgt tcacgaactc gtacgaggcg tcgccgccct cgatcggctc gatcgcgatg
    15901 atgacgcggg cgaactggcc ggtaccaccc gtctgcttct tgtgggtgaa ctcgaccttc
    15961 tcgaccgact tgcggatggt ctcgcggtac gcgacctgcg gcttgccgac gttggcctcg
    16021 accttgaact cacggcgcat acggtcgacc agcacctcga ggtgcagctc gcccatacca
    16081 ccgatgatgg tctggccggt ctcctcgtcc gagtggacct ggaaggacgg gtcctcctcg
    16141 gccaggcgct ggatcgcgac gcccagcttc tcctggtcgc ccttcgactt gggctcgatg
    16201 gcgacctgga tgaccggcgc cgggaagtcc atggactcca ggatcaccgg ggccttgtcg
    16261 tccgacagcg tctcaccggt ggtggtctgc ttcaggccca tgacggcgac gatgtcgccg
    16321 gcgcccaccg actcgatctc ctcacgcttg ttggcgtgca tgcggtagat cttgccgatg
    16381 cgctccttct tgcccttgac ggagttcagc acctgggtgc cggactccag gcgaccggag
    16441 tacacgcgga cgaaggtgag cttgccgagg tgcgggtcgc tcatgatctt gaacgccagc
    16501 gcggcgagcg gctcgtcgtc cgacggcttg cgcgcgatga cctgctccgg gtccttgacg
    16561 tcgtggccct cgatggcctc gatgtcgacc ggcgacggca ggtagcgcac gaccgcgtcg
    16621 agcaggggct ggacgccctt gttcttgaac gcggtgccgc agaacacggg ggtgacggtg
    16681 gtgccgccgc ccttgccgga cgcgatggtg atacgacgga tcgcggcgta gagctgctcc
    16741 acggagggct cggtgccctc caggtacagc tccatgagct cctcgtcgtt ctcggcgacg
    16801 gcctcgagca gcttgccgcg gtactcctcg gcagcctcga tgtgggtgtc cgggatgtcg
    16861 acggtgtcgt acatctcgcc cttggtcgcc tcggccgacc agaccagggc cttcatcgtc
    16921 acgaggtcga tgacgccctt gaagtccgcc tccgcaccga tcggcagctg catgaccagc
    16981 ggctgcgcgc ccaggcggtc ggagatcatg tcgacacagc ggtggaactc ggcaccggtg
    17041 cggtcgagct tgttgacgaa gcagatacgc ggaacgccgt agcggtccgc ctgacgccac
    17101 acggtctcgg actgcggctc aacgccggcg acgccgtcga acaccgtcac ggcaccgtcg
    17161 agcacgcgga gcgaacgctc cacctcgacg gtgaagtcga cgtggcccgg cgtgtcgatg
    17221 atgttgatgg tgtggtcgac gtcttccagc ggccagtgac aggtggtggc agcagaggtg
    17281 atcgtgatgc cacgctcctg ctcctgctcc atccagtcca tggtggcagc gccgtcgtgg
    17341 acctcaccga tcttgtacga aacgccggtg tagaacagga tccgctcggt ggtggtcgtc
    17401 ttgcccgcgt cgatgtgggc catgatcccg atgttgcgga ccctggccag gtcaagcgaa
    17461 gtggtagcca taaggcttca gtcttctctc ggtctcgatg gggtctgcga ctaccagcgg
    17521 tagtgcgcga aggccttgtt ggactcggcc atcttgtgcg tgtcctcgcg cttcttcaca
    17581 gcggcaccga ggccgttgga cgcgtcgagg agctcgttga gcagacgctc ggtcatggtc
    17641 ttctcgcgac gggcgcggga gtaaccgacc agccagcgca gcgccagggt gttggcacgg
    17701 ccgggcttga cctcgaccgg aacctggtag gtggcgccac cgacacggcg ggacttgacc
    17761 tcgagggtcg gcttgatgtt ctcgagagcg cgcttcagcg tgatgaccgg gtcgttgccg
    17821 gtcttctcgc gcaggccctc catggcgccg tagacgatgc gctcggcggt ggagcgcttg
    17881 ccgttcagca gcaccttgtt gatcagggag gtcaccagag gagagccgta gaccgggtcg
    17941 atgatgaccg ggcgcttcgg ggcggggccc ttacgaggca ttcttacttc tccttcttgg
    18001 cgccgtagcg gctgcgggcc tgcttgcggt tcttgacacc ctgggtgtcg agcgagccgc
    18061 ggatgatctt gtagcgaaca cccggcaggt ccttcacacg gccgccgcgc acgagcacga
    18121 tggagtgctc ctgcaggttg tgtccctcac ccggaatgta ggccgtgacc tcgatgccgc
    18181 tggtcagacg cacacgcgcg accttacgca gggccgagtt cggcttcttc ggggtggtcg
    18241 tgaacacacg cgtgcagacg ccacgacgct gaggggaacc ctcgagtgcg ggcgtcttgt
    18301 tcttctcgac cttgtcctgc cggcccttgc ggaccagctg ctggatcgta ggcactactt
    18361 ctccggtttc tgtgtgccga tgggtacagc taacctggaa cgtcgccgac ccacgcggtc
    18421 gggtgtgtcg aatcctgcgg actcccgccg caaggcagaa agaggcgcgg atcacggtgg
    18481 ccggtcacag ctccctatgc ggttgaaggc acgcaggaga gccaaggcac accccaggca
    18541 caaggtctga gcgtacctac ctcacggact tcggtcaaaa caaatggagc ccaccccgac
    18601 acgccggact tctcacctcc atacctgcct ttcgtcctcc cgtcgcgccg atggccgaaa
    18661 cacgctcttt ccgcgtcggc ggtcttgcac gttcagtacg ttgatccgcc cgcggcgaca
    18721 aacgggggaa tgcgcatgac aatagggacg tacgctccgg acgacggcgg cctggacgac
    18781 cgggtgccgt tcctggcacg gctggagagc gaggaccgct ccgcgctgct ggccctcggc
    18841 cgcaccctgt ccttcacccg gcgcacgatc ctgctgcacc agcacgagcc gtcctcccac
    18901 gtgctcttcc tggtggacgg ctggacgaag gtcaccgcgt cggccgccaa cggctacgag
    18961 gccctgctgg cgctgcgcgg ccccggcgac atcatcggcg agtcggcggc gctgaccggg
    19021 cggccgcgct ccgccacggt caccgcgctt gagccggtgc gggcggtggc cctggagcgg
    19081 gaacgcttcc gcgacttcct ggggcgctcc cccgccgtgt cgttcgccct gctcggcctc
    19141 accgcggacc gcacccgggc agccgaccgg cgccggctgg agttcgcgtc gatgagcgtc
    19201 cgcgaacggc tcgccgtcct gctcctcgaa ctcgcccgca cccacggccg gcgcaccccc
    19261 gacggcgtcg aactcgccgt accgctcagc aagcaggagc tggccggctc ggtgggcgcc
    19321 tcccgcgaga tggtgcagcg gctgctgaag gaactccggg acaaggaggc cgtgatcacc
    19381 ggccgccgca ccctgctgat ccgccgcccg gacgtcctgc gccgcatcgg cgccaccgcc
    19441 ccggcgcccg gaatccccgc gccgccgggg ccccgcgagg agtgacccgc gggtcccaat
    19501 cgcccatctg tgcacacggt cacactccga atgggtcatc cgccctcacc accacacgcc
    19561 ccggacgacc actctgctgc atgcccgcca cccccgttcg agaggcgacc atgagcgacc
    19621 ccgtgagccg cacgatcctg ctgctggaca tcgagaggtt cagcgaccgg gacgacgtgg
    19681 aacaggcgta cctgcggcgc atgctctacg acatcaccga ccgcaccctg gaacgcgccg
    19741 gcatcgacga gacccggcgg ctgcgggccg accgcgggga ctcggtgatg gagctcatcg
    19801 acgcgaacgc ccccgtcacg gcactgctgc gggccctgct caccgaagtg ccggcccagt
    19861 tgcgggcggt caaccgcatg gcgtcccgct ccgcgcagat ccggctgcgc ggcgtggtcg
    19921 cctccggctg ggtcgccgtc gacgaccggg acggctgggt cggctccgac ctgaaccacg
    19981 cctgccgtct gctggacgcc gacgtgctgc gcgccgcgct gcgcgagcgc gccgacgact
    20041 tcgcgctgtg cgtctcggac ggcctgtacg ccggtgtcgt acggcacgac cacccgggca
    20101 tcccggccga cggcttccac gcggtgacgg tggccagcaa gaacggcccg ctgacggcct
    20161 ggctgcacgg gccgctcccc gccggcggct tcggggcggc ccacacggac cacggtgaga
    20221 gggggaaggg ggacgcgccg ggcggatcgg gggaccgccc ggcgcctccc acgccggagg
    20281 gcacgcgggc gtctgcggct tcggcagctg gtggtgagct ggtccgctcg ggttcagccg
    20341 gcgacggggg gcaggcgcat ggggccgcgg ccgacgaggg cgagcacgcg cctgcggccg
    20401 tcactggtga cggcgagcac gcaccggggg ccgccggcgg cgacggacgg cgtgcacctg
    20461 cggcctccgc cggcgacggg cggcacgccc ctggagcctc cgccggcgac ggcgagcacg
    20521 cgcccgcggc ccccgcagcc aacggcaacc acacccccgc agcccccacg gcccccgcgg
    20581 ccgacgggcg gcaccagagc ggcccggcgt cggacggatc gggggccccg gcgccgggct
    20641 ccgggctgca cgtcagtggc ggctcggtca gtttcggcgg gggctacgcc gcgggcgacc
    20701 agcacgcggt gtccggcggg caggtcaccg gcgacgtcgt gatgggcggc aagcaggtcg
    20761 tcatgggcga caaggcgcag cggggtgagc ggccgtgacc gccgggcagg agccgcaggg
    20821 cccggcaccg gcggcgccgg gcggcgggcc cgcgccggac cagggcggcg acccggcccc
    20881 ggacgaggcc cgcaaggagg gcggcgccga ggagtccgag gagcgggacc agccgcagaa
    20941 cgcctggtcg gcgcggcgcg acctggtcga ccacagcccc cgcaccatga acgtcggcgc
    21001 ccgcaccagc ttcggcggcg gctacgcggc cggcgaccag cacggcgtca gcggcggccg
    21061 ggtcaccggc gacgtcatca tgggcagcaa gacggagatc caccactggt cgttctccgg
    21121 gctgtccgcc gccgcctccg tcaccgcctc cggcgagatc ccccgcgcca ggctggaccg
    21181 gctcgccgag tccttcgtag ccgccgagga gaccgtcgag ggcctgctgg accggctgcg
    21241 ccgcgaacgc gtcctggtgc tgtccggcgc ccgcttcacc ggccgccgca cggccgcgct
    21301 gatgctgctg caccggctcg gcgcgtcccc cgtgcacgtc ctggaccgcg acacgtcccc
    21361 cggcgcgctc tccgagcgcc tgaccgcacc cgccgacggt gccggcggca cccgcggcta
    21421 cgtcctgtgc gacctggcga cccggcgcgg cagcccgctg cgcgagccgc acgtgctcgc
    21481 cgcccgggac cggctcgccg agcaggacgc ctacctggtg atcaccgtcg gccccaccgc
    21541 cgtactggag gacgtgcccg ccgtcgagtg gcggccgccc gccgccgagg acgtgctgag
    21601 cgcgcacctg cgtgccgtga cggacgagga gacggccggg cgcctgctcg gcctgccgga
    21661 cgtcaaggat ttcctgggcc ggggccacca gttgcgcgag atcgccgcgt tcgcccggct
    21721 gctcggccgg tacgccgccg gggaggtcac cgagcaggcc gtcgccgact tctccctcat
    21781 ctccctggag aaccaggtcc aggagtggtt cgaggaggac gagagcgccg tacacctgcg
    21841 ggacaaggcg ttcctcgtcg cgctcgccgc gttcgacggc ggcccgtacg cgctcaccgc
    21901 cgaactcagc gacctgctct accgcttcct ccagaagacc gagaacccgg cccgcgtccc
    21961 cgaggtcccc gtcttcggca cccacatggg caagcgcctg caactggccc gcgccgagcg
    22021 gtacgagggc gacgagcaca ccgagtgggg cccggtcacc cagacgaagg cggcgttcgc
    22081 cgacgaccgg gtctcgctgg tgctgctgcg cgaggtgtgg acgggccacc cgtccgcccg
    22141 gcccgcgctg accgagtggc t
//
