LOCUS       NZ_LIVV01000012        25275 bp    DNA     linear   CON 28-MAR-2024
DEFINITION  Streptomyces sp. CB02009 scaffold12, whole genome shotgun sequence.
ACCESSION   NZ_LIVV01000012
VERSION     NZ_LIVV01000012.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CB02009
  ORGANISM  Streptomyces sp. CB02009
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 198667)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 198667)
  AUTHORS   Yan,X., Ge,H., Hindra,F., Yang,D., Huang,T., Crnovcic,I. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-AUG-2015) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC Genomics Workbench v. 7.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905825.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:41:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,214
            CDSs (total)                      :: 8,139
            Genes (coding)                    :: 7,984
            CDSs (with protein)               :: 7,984
            Genes (RNA)                       :: 75
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 51 of 155
            Pseudo Genes (incomplete)         :: 117 of 155
            Pseudo Genes (internal stop)      :: 15 of 155
            Pseudo Genes (multiple problems)  :: 26 of 155
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:06:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 147660
            Orig. end                         :: 172935
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LIVV01000012.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25275
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iv"
                     /product="terpene"
                     /region_number="1"
                     /rules="(cds(LANC_like and Pkinase) and not micKC)"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..25275
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="neighbouring"
                     /product="lanthipeptide-class-iv"
                     /product="terpene"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..22838
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /kind="single"
                     /product="lanthipeptide-class-iv"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22838
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12838](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12838)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
     gene            10..342
                     /locus_tag="AMK27_RS36995"
                     /old_locus_tag="AMK27_36540"
     CDS             10..342
                     /GO_function="GO:0051920 - peroxiredoxin activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017948069.1"
                     /locus_tag="AMK27_RS36995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_36540"
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="WP_073918181.1"
                     /transl_table=11
                     /translation="MATASETPVLDTLAAMTVDSVERCGLPPDTFLLTRIAALAASDAP
                     PVSYVAHIDPAIQAGLTAEQVQDVLVAIAPVVGTARVMTAAGNIAKGLGMTIAVAEAEA
                     QAQDSM"
     gene            483..707
                     /locus_tag="AMK27_RS37000"
                     /old_locus_tag="AMK27_36545"
     CDS             483..707
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK27_RS37000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AMK27_36545"
                     /product="hypothetical protein"
                     /protein_id="WP_073918183.1"
                     /transl_table=11
                     /translation="MATPADAVDVIGHVTDRLKKAHPHVAAALVREAVRTAYEEFRYAR
                     VPDYLPVLMESRADELLPSGRENARPGAG"
     misc_feature    506..520
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
     misc_feature    516..526
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            complement(775..1212)
                     /locus_tag="AMK27_RS37005"
                     /old_locus_tag="AMK27_36550"
     CDS             complement(775..1212)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK27_RS37005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AMK27_36550"
                     /product="hypothetical protein"
                     /protein_id="WP_073918185.1"
                     /transl_table=11
                     /translation="MTNADIRRKILRINSYFLMAFGGVSIITGDIWSIWFAPGPWEEML
                     RGEPSVGIGGLEAHGLAFLFGVMLWRASRTAPARQWHVYAAVAHAFLALCNILLWDIYT
                     LVGAVALGYISTIAHIVFATAETIAATRLYDAEPRERQNAA"
     gene            complement(1350..2252)
                     /locus_tag="AMK27_RS37010"
                     /old_locus_tag="AMK27_36555"
     CDS             complement(1350..2252)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015587.4"
                     /locus_tag="AMK27_RS37010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_36555"
                     /product="YhjD/YihY/BrkB family envelope integrity protein"
                     /protein_id="WP_073918187.1"
                     /transl_table=11
                     /translation="MARRGEEGLRGAPGRKDARRAGRTRSAGEWGRAKYRGSWAEHLWR
                     RLDAFDFLNQAILLAATLLLCAVPFMLVATALAGRSAVTGLSRRLGLSERAAAAVGDLF
                     ASSAATSAAVTGLSWVFFVLGGLASAGSLQKLYQQMFQLRPQGLRDIVRALAWLGLVVG
                     CAALASVVGHGMYAQAPVLWWIVNVPAFIAFWWFTMWFLLAGRIPWRSLVPCAVATGVL
                     WMGMLVVFHFVFSGMVTEYDEKYGPIGVVFALMSFFIAVGVVIILGAATGMMWQERGMS
                     FRSAVTTLRRSSRRPSARS"
     gene            2531..2857
                     /locus_tag="AMK27_RS37015"
                     /old_locus_tag="AMK27_36560"
     CDS             2531..2857
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019890588.1"
                     /locus_tag="AMK27_RS37015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_36560"
                     /product="WhiB family transcriptional regulator"
                     /protein_id="WP_079188739.1"
                     /transl_table=11
                     /translation="MTSSPTVNIPGPRTSELLCATADVDPEVFFPPPDAPRNWDRVAKR
                     LCKACPARISCLRTALEHGEKHGVWGGLNGKERSRFTERELPSEAVLRRTLGVRSAREI
                     RPTS"
     misc_feature    complement(2539..2553)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.56"
                     /tool="antismash"
     CDS             3024..3245
                     /gene="allorf_150684_150905"
                     /locus_tag="allorf_150684_150905"
                     /protein_id="allorf_150684_150905"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MTLRIDVSRLLDVQAQSVPEDEDVRVADHSALAVVACHKTCMPRP
                     TTADRVRARRVRLAPHIRPASHAGPSGE"
     CDS_motif       3024..3107
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTLRIDVSRLLDVQAQSVPEDEDVRVAD"
                     /locus_tag="allorf_150684_150905_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       3108..3245
                     /prepeptide="core"
                     /locus_tag="allorf_150684_150905_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="-1.00"
                     /molecular_weight="4730.5"
                     /monoisotopic_mass="4727.5"
                     /core_sequence="HSALAVVACHKTCMPRPTTADRVRARRVRLAPHIRPASHAGPS
                     GE"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTLRIDVSRLLDVQAQSVPEDEDVRVAD"
                     /leader_location="[3023:3107](+)"
                     /alternative_weights="4748.5"
                     /alternative_weights="4766.5"
                     /alternative_weights="4784.5"
                     /alternative_weights="4802.5"
     gene            complement(3430..4473)
                     /locus_tag="AMK27_RS37025"
                     /old_locus_tag="AMK27_36570"
     CDS             complement(3430..4473)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015983.4"
                     /locus_tag="AMK27_RS37025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_36570"
                     /product="radical SAM protein"
                     /protein_id="WP_073918193.1"
                     /sec_met_domain="PF04055 (E-value: 3e-19, bitscore: 63.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 6.8e-08, bitscore: 26.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNGPREVNWDVTYACPLRCTHCYSESGRRPSRRLKPEDRKRVAKA
                     LISLKPKAIQLSGGEPLLMEDLPVLAGMFRDAGIEVGLFTSGWLLDRARLDGLLGVFSS
                     VHVSVDGATAAVHDRIRGRAGSFDRAMRALELLDEATGSGTRPPVAFGIDCTLVRSNFD
                     DMEAMCRDVAGRFAHLGYLSFGAAVPGGLANREGYARHELLTDAQLDALAHPELGARLR
                     ELVPPSLSVQTFDGRALQMHPELVARGYALTNLMQVEPDGRVRGMAMYEGTVGSLLDEP
                     ADVLWSRTRDRVTSDFVVRTLAPVRTMAEWAEAARRIDLHFGSAADRARIAARPPFSPE
                     DTSPAGR"
     cand_cluster    4466..25275
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    4466..25275
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[14465:15275](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(14466..15275)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="2"
     gene            complement(4470..6278)
                     /locus_tag="AMK27_RS37030"
                     /old_locus_tag="AMK27_36575"
     CDS             complement(4470..6278)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="AMK27_RS37030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_36575"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_073918195.1"
                     /transl_table=11
                     /translation="MRADTGWALLRDEMRGNGAALRRLTVWSTVEALPALVTGVAVAKA
                     LDDGFLAGHPAAGTSWLAVVALALLVKALGARAVFAPLADVVEALRDGLTRRLVTATVG
                     RAAAVRQGPDASVIAQLTGHIDTVRTLTSALLRSVLRMGLTVVMAFVGAVSVSPVVGLI
                     AGPPLMVAVLALWRALPVMARRRHVAVLAGEAVSRRMGLFVAGMRDITAAGASERAVAD
                     VTDAAELHAAALRAAARTDATRIAVIAVGCHLPMIALLVSAPWLLRGHLLTVGELIGAM
                     LCLTQGIEPALRAVTNLLGAWGLQLGVVAGRLREVIDGGPSTAAPGSRPDLPRGSDLEF
                     DRVTFAFGASATPVVRAFSLVIPHGEHVAIVGPSGIGKSTLVDLLSGLRPADSGTVRYG
                     GVPLDRIRPDVLRREVTIIPQEAWLAPGTLRENLLYLAAVPNPRALEECVDLLGLAPVI
                     AAAGGLDASLSHRARSLSSGERQLLALGRAYLSPARVVVLDEATSSLDAETEARAESAF
                     AGRENTTLIVVAHRLTSAARADRTVLLEGDHPLVAPHSDLLGMSALYAEAAAHWSVDHV
                     TRPVACGRSALEAPPPPLGDNQGALP"
     gene            complement(6283..8094)
                     /locus_tag="AMK27_RS37035"
                     /old_locus_tag="AMK27_36580"
     CDS             complement(6283..8094)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="AMK27_RS37035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_36580"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_073918197.1"
                     /transl_table=11
                     /translation="MRRFALRSARTGSPQASSPTSSRAGRDADRLLVRTVATSRRSAAV
                     LVLGVALRSFTSLLIPAAIAAALDSASREQGLAQAVRPSVLLVLGVLASAAVLLGSVYT
                     SARAAVWLRVSLARHVLAVGQTGTRDLRHGDLVTRLVGNASETAEASYGLISLLSGFVT
                     PICGVLALWAIDWTVALAFLLTAAPITTISSRFFRSYSRNQSRYQEIQGELSASLSDVT
                     DGARSIAAMGTAQREIDRVLQPLARLSAEGRESWTAQKKATWRSSLLAPVCEFTVLVVA
                     GFKVSAGDISPGSLVAVTAYTAMALGLLDNLDPLARLARVRASAGRLVDVLGRPTPEAG
                     EVTPPVGPGALTLRSVTVTRGDQVVLDAVDLDVPAGSKVAVVGRSGSGKSALAGVIGHL
                     VRPDSGEVRLDGVPVSTMAPAARARSVVYAFARPEPLGGTVGDDITYGLSPEPTDEETV
                     ASARTACADAFIDRLPGGYGTPLHGLALSGGERQRLGLARAAARLKGACVLVLDEATSH
                     LDALTEVLVGRAFDTGRTEIAVTYRAATAARADVVLWMEDGRIREAGPHDRLWNIPAYR
                     SVLAVDGGAVVTPLEAVCESAKAEHDG"
     gene            complement(8091..9926)
                     /locus_tag="AMK27_RS37040"
                     /old_locus_tag="AMK27_36585"
     CDS             complement(8091..9926)
                     /NRPS_PKS="Domain: Abhydrolase_1 (374-489). E-value: 3e-09.
                     Score: 28.8. Matches aSDomain:
                     nrpspksdomains_AMK27_RS37040_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012546.4"
                     /locus_tag="AMK27_RS37040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_36585"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_158076952.1"
                     /sec_met_domain="PF00561 (E-value: 8.1e-08, bitscore: 25.6,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_S9 (E-value: 4.4e-24, bitscore:
                     78.5, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEEPHRKSFAFSDHARHIACLRLTRSGWGVESWFGGAADRTPRM
                     LTTGGQSLATQLVPLDDGRVVLTRPSGGRHEIVLLGPGEGDHEAQERTLARSDAPSLRL
                     VAGQGPSWSAVAVTTEEGGSSLWTVAEDSTKLRLVVPQNRLQGMLRNGTRLDRHGLRMG
                     FDLLQEGRSRPVGIDLITGRVEPLTNPPAPGGAQGAPEADGTGRLLLAAPDAETALLVS
                     TSASGTRLVLVTDGVERPLPAAALVDPAGGPTPLPIALSPDARHLLLLVTEGARTRLLR
                     GSLDSRALPVKVAGDAEALFLPSARWTDRLQVIGSTPDEPSRPWVIAPRRTPPARTRRV
                     PRRRAVAHTEVLPGADDDMEVVVYGGRDWCVSRHLVIALHGGPEASWKLDHSPFFRRLA
                     KAGIAVVAPNQRGSTGYGAAHRLAVRGAWGGPDLDDVLRMSEALARRRRGMPPMTLYGE
                     SYGAHLALLAAAHRPHLWSRCAVSAPFLSPESLHGMANTSVRAFLARHGAWPHQPSGSA
                     HEPRTAEACLDRITAQLLVVHGTGDEVVPVGQSLELRRRLAAHGRREGEDFVVREASGG
                     HNVLSGPQGSRLQEEVTAFLLSGCGALIPSGGGDL"
     aSDomain        complement(8460..8804)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMK27_RS37040_Abhydrolase_1.1"
                     /evalue="3.00E-09"
                     /label="AMK27_RS37040_Abhydrolase_1.1"
                     /locus_tag="AMK27_RS37040"
                     /protein_end="489"
                     /protein_start="374"
                     /score="28.8"
                     /tool="antismash"
                     /translation="LVIALHGGPEASWKLDHSPFFRRLAKAGIAVVAPNQRGSTGYGAA
                     HRLAVRGAWGGPDLDDVLRMSEALARRRRGMPPMTLYGESYGAHLALLAAAHRPHLWSR
                     CAVSAPFLSPE"
     gene            complement(10001..12838)
                     /gene="lanL"
                     /locus_tag="AMK27_RS37045"
                     /old_locus_tag="AMK27_36590"
     CDS             complement(10001..12838)
                     /codon_start=1
                     /gene="lanL"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: Pkinase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038150.1"
                     /locus_tag="AMK27_RS37045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_36590"
                     /product="class IV lanthionine synthetase LanL"
                     /protein_id="WP_073918201.1"
                     /sec_met_domain="Pkinase (E-value: 2e-17, bitscore: 56.8,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 5.8e-50, bitscore:
                     163.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHRKTAAGREPLADLRLLTDLAEAAVARHGGGWTLRKDDFWCRVV
                     PPRHSSADQGWKIHLSATPLSAPLVLARGAEILLSAGCFFKFARDLDRATTLVDRNQPR
                     GYGGKFLTAYPEDNETCRALARRLHDATSDLHGPRILSDRPYAPGSLVHFRYGVFAAKP
                     TLTPDGSFEFLLRAPDGSLIKDERRAWFSPPSWASSPPFDAPPPRPAGDATTAVLVGGR
                     FRVSKAIKHANRGGVYRALDQRTGAEVVLKHARPHVDARLDGTDARDVLRHEAQILDAL
                     APLGIAPRTVALVEQQGSLFLAQEHVPGVTLRRWATDHVHASGTGTGVPLHEVAALAPK
                     VATLLDRAHGVPGLVLRDVTPQNIMVTPDGEVVLVDLEGAVTEGEPARRMYTPAYGAPE
                     QSTAPRFAPAPARSVDAYALGMVLFFLATGRDPLIVGPSPGTEAGQGRRTALIEAMQES
                     QPGLRALAPVIKGLTADEPTDRWQIRQAVAHLERSASVTGSVAPPYEARRAEPDARATP
                     ADPSRICGTQTTAATGSHTENLVEGGLQHLLNTMRPDEDRLWMSGQFGSTTDPCNVQHG
                     AAGVLGVLVQAARSVSDATYRESVQRVAEWTARRSREVPSSLPGLYFGRSGTAWALYDA
                     ARFLDDEELASRAVEMLETVALDWPNPDICHGLSGAGMALLHVGGESGRPSLTASALTC
                     ADRVLEGGRREKGRILWPIPSEFRSDLAGVVHYGFAHGVAGAGAFLLAAAQFSGRQAYL
                     DAAVEAGRTLCAVAETSRGAARWPAGPSPRQDGQRDMQHWCSGASGVGTFLARLWRVTG
                     DDRSLDLSRQAAETVHRARWNVGNAACHGLAGDGDFLVDMAQLTGDARYQHMARDVAEV
                     MYVLRAERGGLGLVTDESGHSVTADYGTGLSGALGFLMRLEHGGARLWMPGPRRSATPF
                     PGMPRLAPTPRAGTP"
     gene            complement(13100..13219)
                     /locus_tag="AMK27_RS43140"
     CDS             complement(13100..13219)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF038157.1"
                     /locus_tag="AMK27_RS43140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ALQxL family class IV lanthipeptide"
                     /protein_id="WP_198956003.1"
                     /transl_table=11
                     /translation="MTFDVDFLEEIVADEPEGLWPCEKTCTATCGITCTATQA"
     misc_feature    13290..13303
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.41"
                     /tool="antismash"
     misc_feature    complement(13580..13593)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.22"
                     /tool="antismash"
     gene            13728..14432
                     /locus_tag="AMK27_RS42805"
     CDS             13728..14432
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF022655.4"
                     /locus_tag="AMK27_RS42805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF2993 domain-containing protein"
                     /protein_id="WP_158076953.1"
                     /transl_table=11
                     /translation="MNSWRNKFPCLRSKGRTALALSVFGAFAVLLPLGEMATRGYATWK
                     IASVAERRIHTDAEVSLGSTPAVLQLGSGKFSDVKVEARQADFGKNVKVDFVAHLMNLS
                     RNSSGASVESSKVRAEVTEEAMSASRSAEGGGNVEADPETGTLVAHVGPGGGIDIPLTP
                     SLAGDKVTLTAGDPTFSGNPVPSGLADMIKSKAELTVDMSDLPLGLKVDALAVTSTGLQ
                     LDLSGGPATLEQ"
     gene            complement(14466..15275)
                     /locus_tag="AMK27_RS37055"
                     /old_locus_tag="AMK27_36600"
     CDS             complement(14466..15275)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: TS_UbiA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ubiA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF013226.4"
                     /locus_tag="AMK27_RS37055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_36600"
                     /product="UbiA family prenyltransferase"
                     /protein_id="WP_158076954.1"
                     /sec_met_domain="TS_UbiA (E-value: 6.1e-62, bitscore:
                     202.6, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="ubiA (E-value: 1.2e-25, bitscore: 83.8,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSSNVLIALLPALVTILAAARFSGTEPVRSVCFGGVHFLLAICV
                     FDLSNQIVGVPEDRVNKPSRPLVTGLLTLRGAWWRLAAATVALLFSGWLLGIVHLALLW
                     VVVAGANNHLGLAKRPFLKPLIVGVQAGIQLLSAWQVGGGEPARFVPCVIAVSALLMLL
                     MPLQDLRDVAGDRCMGRRTLPLVYGARAVRIYLCVGFLLTPVAVRLLVEAHVLWTGGWV
                     EAVAAVICAATAVRVVTLRSPASDDATYRLLVLWYTAMAAAPLAATF"
     misc_feature    complement(15054..15056)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(15599..15614)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.03"
                     /tool="antismash"
     gene            15882..19202
                     /locus_tag="AMK27_RS37060"
                     /old_locus_tag="AMK27_36605"
     CDS             15882..19202
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012311.4"
                     /locus_tag="AMK27_RS37060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_36605"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_073918207.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 1e-58, bitscore:
                     192.4, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEQHKRGRLLAAAMAALMVAGGAGTAVAAATADGSPSLKASADA
                     KPVSVRTVTLVTGDQVVLTGFAGGREGVTVRPGPGREHVSFTYRSHGDSLSVIPSDALE
                     LLRSGAVDARLFDVQALEAMGYDDAARATLPLMVRYDATDRGQGARSAVSRLAAPRTTL
                     KSVNADVVATPKAKAGEAWEAMTQKRGMSRVLASGVSTIWLDGAVKASLDKSVPQIGAP
                     DAWHDGLTGRGVLTAVLDTGIDPAHPDLADAVVTSQDFTGSANGTADAHGHGTHVASII
                     TGDGSASAGRYAGVAPDTKLLVGKVLNSKGQGSESGTIAGMEWATSHGAKVVNMSLSAS
                     ATDGTDPMSQAVNSLTASTGALFVVAAGNEGVNEKVSSPASADAALAVGAVDADDQLAD
                     FSSRGPRLVDSAVKPEITAPGVGIVAARAAGTSHGDVVDDHYTKLNGTSMATPHVAGAA
                     ALLAQQHPDWDAARLKDALTSTAKPTAGLDVFAQGAGRVDLTRAVRQDAYATPGTLSNY
                     LKWPHATPVKRTVTYHNDGDEPLTLSLDVTLDGSGENGRLITPDADQLTVPAHGTAAAQ
                     LTIDPAQADAGTYSGVLTARSADGQTVVRTALGVFSEDEVYDTTIRLTDRAGETLSPAL
                     LQLINLDTGEGFDARAVGDALVGRVPKGRYTANAVIFNSTGSVQSATLVSQPDVVVAGD
                     TTVKLDARAGKIVQADVGTETQADTRWVGINETIAGVLNEFRVFTQDPEAVLYAAGTPA
                     VTSRPYTFVHLAALHAPAVPGRPEAAYNLALTRDGGIPADPSFQVRSDELAKVRVRYHT
                     QGDPAPAHRSNLASFDGSARASGGGYNVKLASEHTEYFTATNRVKWLGALDTGTSFETS
                     PLTQYKPGNATTEEWNKAAISPAAPDAGRCENSLFAPIQAFSTSAAGHLASAFEYTGTA
                     TLLRDGEEIGTTDDPQFAFFTDLPAGPSRYTLRLAAHHDTPAVALATKVDAEWTFSSAE
                     PEEGCEKPQKLPLLNTRIGAGFDLNNSAPADKPLPVTIKVERADAETPAVKALSLETTF
                     DDGATWHKVPVKSTGSASFSAVVPPVAAGNGYVGLRTTATDTDGNELKQTVLRAYRLR"
     gene            complement(20276..20692)
                     /locus_tag="AMK27_RS37070"
                     /old_locus_tag="AMK27_36615"
     CDS             complement(20276..20692)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK27_RS37070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AMK27_36615"
                     /product="hypothetical protein"
                     /protein_id="WP_143204920.1"
                     /transl_table=11
                     /translation="MNEFTGMRKITSVDRLNTTQLEQLRLSGIAYDGQDLPPEERISSH
                     DESELESVLNSCELWDVATDGFVVFEAWLYQGDSGSIFKAGTTEMIAEIIQCGLECDDD
                     DIELKIGMAMVQSNLLPTGDSEYERFSSALKALQ"
     misc_feature    20810..20825
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.04"
                     /tool="antismash"
     gene            complement(20814..21227)
                     /locus_tag="AMK27_RS42810"
     CDS             complement(20814..21227)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK27_RS42810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_158076955.1"
                     /transl_table=11
                     /translation="MGDDDPVLEGTVLPGRVKELRSSEREGLNVNGGSFAEFERAGIAL
                     EAGEGLAVSLEGALAEHDAGGGAAVGKVGSDVVEKLIRGHGRILVRVGELVASVEGLRH
                     KKFLAQHNSRQGALRTSCRRLVNHFAPHAAENE"
     gene            <21302..21532
                     /locus_tag="AMK27_RS41405"
                     /pseudo=""
     CDS             <21302..21532
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008744193.1"
                     /locus_tag="AMK27_RS41405"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="ECGLDEYEVRRYIGWYRHITLAMLAHAFLAGLAAECSKGCETTPP
                     ALLPSPWQRSAGSWNISCPQPEPGAILDITQ"
     gene            complement(21688..21870)
                     /locus_tag="AMK27_RS42495"
                     /old_locus_tag="AMK27_36620"
     CDS             complement(21688..21870)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK27_RS42495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AMK27_36620"
                     /product="hypothetical protein"
                     /protein_id="WP_143204921.1"
                     /transl_table=11
                     /translation="MENAKPATGEYPDIDELSLLLAGVAALAAIGWLRRIGPIEAPHDD
                     NEVNQPVKGLVHRVL"
     gene            21912..22373
                     /locus_tag="AMK27_RS42500"
     CDS             21912..22373
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK27_RS42500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_143204922.1"
                     /transl_table=11
                     /translation="MVDTVAASAADFGGPVAAPDRRPHPKGGLHGRIVVHVGEFSLVRN
                     HMHVDCGAVGLTNSHTANLTVLLLPSNGLYSCPRAKGCPAKISGAELVADERAYGLSAW
                     PQTNLGKATELLRQAVAEISVSDQGALRVLFAGGLACWCRSMTSGQHGQ"
     misc_feature    complement(22497..22511)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 19.02"
                     /tool="antismash"
     gene            22512..23282
                     /locus_tag="AMK27_RS37075"
                     /old_locus_tag="AMK27_36625"
     CDS             22512..23282
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009188870.1"
                     /locus_tag="AMK27_RS37075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_36625"
                     /product="IS5/IS1182 family transposase"
                     /protein_id="WP_073918211.1"
                     /transl_table=11
                     /translation="MASVITASEPSWIAPFAGLSPRCFSELLTALRRDGADVIHRGRPW
                     SLPLEDRVLLVTAYWRTNLTLRQLAPLFGVSKSTAGRVINHLGPLLALRPRKRFAKDAV
                     LIVDGTLVPTRDHVIGERSKNDRYSTNHQVVIDADTRFVVAVGRPLPGNRNDCKAWELS
                     GAKAAVGRATVIADGGYRGTGLIIPHRREHGQAELPAWKEEHNASHRKVRARVEHAFAR
                     MKAWKILRDCRLKGEGVHHAMRGIARLHNLALVG"
     gene            23850..24359
                     /locus_tag="AMK27_RS37080"
     CDS             23850..24359
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017949058.1"
                     /locus_tag="AMK27_RS37080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding protein"
                     /protein_id="WP_241847721.1"
                     /transl_table=11
                     /translation="MFTAPKIMVTFGESHGRRPATARGASVRPVKIPAPRPPSDDKAWP
                     LEHVPQSVRTARRIATQALTAWEVPEEAQQIALLVVSELVTNAVEHAQAPMALHLHRRR
                     AERELWIGVTDGGPAEVEGAWTTSCTPDEHGRGLALVDSLTEDHGTYSHVMPPATTHWA
                     RLPAAV"
ORIGIN
        1 agccccgcca tggccacagc atcggaaacc cccgtcctgg acaccctcgc cgcgatgacc
       61 gttgactcgg tggagcggtg tggtctgccc ccagacacgt tcttgctcac tcggatcgca
      121 gccctcgcgg cttcggacgc ccctcctgtc tcctacgtcg cccacatcga ccccgcgatc
      181 caagccggcc tgacggccga gcaggtccag gacgtcctgg tcgccatcgc cccggtggtg
      241 ggaacagccc gggtgatgac tgccgcgggc aacatcgcga agggtctcgg catgaccatc
      301 gcggtggccg aggcggaagc ccaggctcag gactcgatgt aaggggagcc tgtacgaggc
      361 ggcactcgca gcagtggaat ccggcgtctc ggccatgacc gcggctgtcg gcggctgcac
      421 gcgagtgtcg cgctcacgcg ggggtgtgag ggcaacggat tcgaccaggg cggaggggcg
      481 ccatggcaac acctgcggac gccgtcgatg tcatcggcca tgtcaccgac cggttgaaga
      541 aggcgcatcc tcacgtggct gccgctctgg tgagagaagc ggtacgaacg gcctacgagg
      601 aattccggta cgcgcgcgtc cccgactacc ttcccgtcct gatggagagc agagccgacg
      661 agctgctccc ctccggaagg gagaatgcta ggcccggcgc gggctgatgc catcgccgct
      721 ccccggatcg tcgacgcacc gccctccttc gggggtcggc gcgtcgacga cggctcaggc
      781 cgcgttctgc cgctcgcgag gctcggcgtc gtagagccgg gtcgcagcga tcgtttcggc
      841 cgtcgcgaag acgatgtggg cgatggtcga gatgtatccg agggcgacgg cgccgactag
      901 ggtgtagatg tcccagagga gaatgttgca caacgcgagg aaggcgtgag cgacagccgc
      961 gtatacgtgc cactgcctcg ccggagcagt gcggctcgcg cgccacagca tcactccgaa
     1021 aagaaaggcg agcccgtggg cttcaaggcc gccgattccc acggagggtt cgcccctcag
     1081 catttcctcc cacgggccgg gagcgaacca gattgaccag atgtcacctg tgatgatcga
     1141 gacgccaccg aacgccatga ggaagtatga attgatgcgc aagatcttgc gtctgatgtc
     1201 agcgttcgtc atctgtgcca cctcgcgcct tcacggaatg ccttcctcag cataggactg
     1261 cacgatgcgg tccgctagag agtcacgtta cgccggaggc cgggcacttc gatccgcaat
     1321 ggctactcat gcagggtgcg tgtccaccgt cacgatcggg ccgacggccg tctcgaggac
     1381 cgcctcagtg tggtcacggc gctccggaag gacatgccgc gttcctgcca catcatgccc
     1441 gtggccgcgc cgaggatgat caccaccccg acggcgatga agaacgacat gagggcgaag
     1501 acgacaccga tcgggccgta cttctcgtcg tactccgtga ccatgccgga gaacacgaag
     1561 tggaagacga ccagcatccc catccacagg acgcccgtgg cgacagcgca gggcaccagg
     1621 ctgcgccacg ggatgcgccc cgccagcagg aaccacatcg tgaaccacca gaacgcgatg
     1681 aaagccggga cgttgacgat ccaccacagg acgggcgcct gggcgtacat gccatgcccg
     1741 acgacgctcg ccaaagcggc gcagcccacg accagaccca gccaggccag tgcgcgaacg
     1801 atgtcccgga gaccttgcgg acgcagctgg aacatctgtt ggtacagctt ctggagcgag
     1861 ccggcggagg cgaggccgcc caggacgaag aacacccacg acaggccggt gaccgctgcc
     1921 gaagtcgccg cggacgaggc gaacaggtca cccacggccg cggccgcccg ttcgctgagc
     1981 cccagtcgcc ggctcagtcc cgtcaccgcc gaccggcccg cgagggcggt cgcgacgagc
     2041 atgaacggga ctgcacagag gaggagggtg gcggccagca ggatggcctg gttgaggaag
     2101 tcgaacgcgt ccagccgacg ccacaggtgc tctgcccatg atcccctgta cttcgcccgg
     2161 ccccactcac cggcggaccg ggtccggccg gcccgcctgg cgtccttcct gcccggcgct
     2221 ccgcgcagcc cctcttcgcc ccgccgcgcc attcggtcgt cacctggcct gcccgatgct
     2281 ctgtccctcg caggcatgac gcacacctcc agggctgatc cctccggccg cgcgggacga
     2341 ccgcgtgcgg cggcgcgcgg ccggggcacg gtcctccatc caccgtcgca cgccacccgg
     2401 gccctgtcag atttcggatt ccggacggtc ctctaccgcg gagggcaagt gagtattctg
     2461 cactcacggc aaacggaacc ggagaacgca tgatgggtgc gcagcgtatg cacctgatgg
     2521 aaagactgcg atgacttctt ctccgactgt gaacatcccc gggccgcgga caagtgaact
     2581 gctctgcgcc actgcagatg tggatccgga ggtgttcttc cctccgcccg acgcgccccg
     2641 caactgggac cgcgtggcaa agcggctttg caaggcctgc ccggcgagaa tctcgtgcct
     2701 tcgcacagct cttgagcacg gtgaaaagca tggcgtctgg ggcggattga acggaaagga
     2761 acgctcgcgt ttcacggagc gagagcttcc gagcgaggca gtgctccgtc ggacgctcgg
     2821 agtgagaagc gcccgggaga ttcggccgac atcctgatat caggcgtccc ggtcccggaa
     2881 cggtatcgcc tgcgcacggg cgggggccgt gtcgaacggt gtggagtttc gaagcggggc
     2941 gaggcacgta gggccgagtt cgacgaggca ttcccggacg agatcccgcc cgctgccccg
     3001 gagcgtgccg cggacgccgc ccgatgaccc tccgcatcga cgtctcccgg ctcctcgacg
     3061 tacaagcgca gagcgttccc gaggacgagg acgtcagggt cgccgaccac tccgccctcg
     3121 ctgtcgtcgc ctgccacaag acgtgcatgc cacgccccac caccgccgac cgcgttcgag
     3181 cccggcgcgt ccgactcgct ccgcacatcc gcccggcgtc tcacgcaggc ccgtcgggtg
     3241 agtagaaact actgaggcgc gaacccggtc gttcacggac tctggtgaca aggggggcca
     3301 aatccaactt tctgccctat caggcagaaa gttccgatat cggcccgctg tgggatcggg
     3361 caagcccgat ggcgtgtgcc tgccccgacc cgtgcccctg gacggacgct cggccgacgc
     3421 gggacgtgcc tatcggccgg cggggctcgt gtcctctggt gagaacgggg gccgggccgc
     3481 gatccgtgcg cggtcggccg ccgagccgaa atggagatcg atgcggcggg ccgcctcggc
     3541 ccattcggcc atggtgcgga ccggtgcgag cgtccgcacc acgaaatccg acgtgacccg
     3601 gtcccgcgta cggctccaga ggacgtcggc gggctcgtcc agcaggcttc ccaccgtgcc
     3661 ttcgtacatc gccatgcccc ggacgcgacc gtcgggctcc acctgcatga ggttggtcag
     3721 ggcatacccc cgggcgacca gctccgggtg catctgcaga gcgcgcccgt cgaaggtctg
     3781 tacggagagg gagggcggca cgagctccct caggcgcgcc cccagctccg ggtgggcgag
     3841 cgcgtccaac tgcgcgtcgg tcaggagttc atggcgcgca tagccctcac ggttcgccag
     3901 gcccccggga acggcagcgc cgaaggacag gtacccgagg tgggcgaacc ggcccgccac
     3961 gtcccggcac atggcttcca tgtcgtcgaa gttgctgcgg accagggtgc agtcgattcc
     4021 gaaggccaca ggcggccgag tgccgctccc ggtagcctcg tcgaggagtt cgagggcgcg
     4081 catcgcccgg tcgaaggagc cggcccgtcc tcggatgcgg tcgtgcactg ccgcggtagc
     4141 cccgtccacg ctcacgtgca cgctggagaa caccccgaga agaccgtcaa ggcgcgcacg
     4201 gtcgagcagc cagccgctgg tgaacaggcc cacctcgatg ccggcgtccc ggaacatgcc
     4261 ggccaggacg ggaaggtctt ccatgaggag aggttcccct ccgctcagct gtatcgcttt
     4321 cggcttcagc gagatgaggg ctttcgccac cctcttccgg tcctccggct tgagccggcg
     4381 cgagggacgg cggcccgatt cggagtagca gtgcgtacag cggaggggac aggcgtaagt
     4441 gacgtcccag ttcacttcac gggggccgtt catggcaggg ctccttgatt gtcgccgagt
     4501 ggcgggggtg gggcttcgag ggcacttcgc ccgcaggcga ccggacgtgt gacgtgatcc
     4561 accgaccagt gcgcggcggc ctctgcgtag agcgcggaca tgcccaggag atcggagtgg
     4621 ggggccacca gaggatggtc accctcgagc aggacggtcc ggtcggcacg agcggccgac
     4681 gtgagccggt gggcgacgac gatcaacgtg gtgttctcac gcccggcgaa ggcggactcg
     4741 gcgcgcgcct cggtctccgc gtccagcgac gacgtcgcct cgtcgaggac gaccacccgg
     4801 gcgggcgaga ggtaggcgcg gccgagggcg aggagctgtc gctcccccga cgacaacgaa
     4861 cgcgctcggt gggagaggga ggcgtccagt ccgcccgcgg ctgcgatgac aggtgcgagg
     4921 ccgaggagat cgacacactc ctccagagct cgcggattcg gaacagccgc cagatagagg
     4981 aggttctccc ggagagtgcc cggcgcgagc caggcttctt gcggaatgat ggtgacctcg
     5041 cggcgcagta cgtccgggcg gatgcggtcc agcggtacgc cgccgtagcg caccgttccc
     5101 gagtcggccg ggcgcaggcc gctcagcagg tcgaccagcg tggacttgcc gataccactc
     5161 ggcccgacga tcgctacgtg ttctccgtgc gggatcacca gactgaaggc acgcacgacc
     5221 ggcgtggcgg acgcgccgaa ggcgaacgtg acccggtcga actccaggtc cgatccccgg
     5281 ggcaggtccg gccgggatcc cggtgcggcg gtcgacggcc caccgtcgat gacttcccgc
     5341 aggcggcctg ccaccacgcc gagctgcagt ccccacgccc cgaggagatt ggtgacggca
     5401 cgaagggcgg gctcgatgcc ctgggtcaga cacagcatgg caccgatcag ctcgcccacc
     5461 gtcagcaggt gaccgcgcag gagccacgga gcggagacga gcagcgcgat catgggcaga
     5521 tgacagccga ccgcgatcac tgcgatccgc gtggcgtccg tcctcgccgc ggcccgcaac
     5581 gcggctgcat gcagctcggc cgcgtccgtc acgtccgcga ccgctcgttc cgaggcaccc
     5641 gccgccgtga tgtcgcgcat ccccgcgacg aacagtccca tgcgccggga cacggcctcg
     5701 ccggccagaa cggcgacatg ccgtcggcgt gccatgaccg ggagcgcccg ccagagggcg
     5761 aggacggcga ccatcaaggg aggccccgcg atcagaccca cgacgggtga cacgctgacc
     5821 gctccgacga aggccatgac gacggtcagg cccatccgga gaacggaacg caggagagcc
     5881 gacgtgagcg tgcgcacggt gtcgatgtgc ccggtcaact gcgcgatgac ggacgcgtcg
     5941 gggccctggc ggaccgcggc cgcccggccc accgtggcgg tgaccaatcg cctggtcaga
     6001 ccgtcccgga gtgcctcgac gacatcggcg agcggagcga acaccgccct ggctcccaag
     6061 gccttgacga ggagcgccaa cgccacgacc gcgagccagg acgtgccggc agccgggtgc
     6121 ccggccagga atccgtcgtc cagagccttc gccacggcga ctcccgtgac cagcgcgggc
     6181 agcgcttcca cggtgctcca caccgtgagc cgccgaaggg ccgcgccgtt gccccgcatc
     6241 tcgtcccgca gcagcgccca gcccgtgtcg gcccgcatcc gctcatccat cgtgttccgc
     6301 tttcgccgac tcgcacacgg cttcgagggg agtgaccacg gcgcccccgt cgacagccag
     6361 gaccgacctg taggccggta tgttccacaa ccggtcgtga gggcccgctt cccgtatccg
     6421 cccgtcctcc atccagagca cgacgtcggc ccgggcggcg gtggcggccc ggtaggtgac
     6481 cgcgatctcg gtcctgccgg tgtcgaacgc gcgcccgacc aggacctcgg tcagcgcgtc
     6541 caagtgggag gtggcctcgt cgaggacgag gacgcacgcg cctttgagac gagcggcggc
     6601 gcgagccagg cccaggcgct gacgttcgcc accggacagg gccaggccgt ggagaggcgt
     6661 gccgtagccg ccgggcagcc ggtcgatgaa ggcgtcggcg caggcggtgc gcgccgacgc
     6721 gacggtctcc tcgtcggtcg gctcggggct cagtccgtag gtgatgtcgt cgccgacggt
     6781 gccgccgagg ggctccggcc gggcgaaggc gtagaccacc gaccgggccc gcgctgcggg
     6841 ggccatggtg ctcacgggca cgccgtccag acgtacttcg cccgaatcgg gccggaccag
     6901 gtgaccgatg actccggcca gagcggactt ccccgaaccc gaacggccga ccaccgccac
     6961 cttggagccg gccgggacgt cgaggtcgac cgcgtcgagc acgacctgat cgcctcgcgt
     7021 cacggtgacg gaccgcagcg tcagggcgcc ggggccgacg ggcggcgtca cctcgcctgc
     7081 ctccggcgtg ggccgtccga ggacgtcgac gagccgaccg gcactggcac gcactcgcgc
     7141 cagtcgcgcc agcgggtcga ggttgtccag gagcccgaga gccatggcgg tataggcggt
     7201 cacggccacg aggctcccgg ggctgatgtc tcccgcgctg accttgaacc cggccacgac
     7261 cagtacggtg aactcgcaga cgggtgccag caacgaggaa cgccacgtgg ccttcttctg
     7321 ggcggtccag gactcccggc cttccgcaga caggcgggcc aggggctgga ggacccggtc
     7381 gatctcccgt tgcgcggtcc ccatcgccgc gatgctgcgc gccccgtccg tcacatcgga
     7441 gagggacgct gagagctcgc cctggatctc ttggtagcgc gattgattcc gactgtacga
     7501 gcggaagaac ctgctggaga tcgtcgtgat cggagcggcg gtcaggagga aggcgagagc
     7561 cacggtccag tcgatcgccc acagcgcgag aacaccgcag atcggagtga cgaagccgct
     7621 gagcaggctg atcagaccgt aggaggcctc agccgtttcg gacgcgttgc ccacgagccg
     7681 ggtcacgaga tcaccgtgcc ggaggtcgcg tgtgcccgtc tgtccgaccg cgagcacatg
     7741 acgggccaag gagacgcgga gccacaccgc ggcacgggcg ctcgtgtaga cgctgcccag
     7801 aagcacggcg gcggaggcga gtacgcccag aacgagcaga acggacggcc ggacggcctg
     7861 cgcgagcccc tgctcccgcg atgccgagtc gagggcggcg gcgatcgcgg cagggatgag
     7921 gagcgaggtg aacgaccgca gggccacccc gagcacgagc accgctgcgg agcgccggga
     7981 cgtggcgacg gtccgcacca ggagccggtc ggcgtctctt ccggccctgg agctcgtggg
     8041 ggagctggct tgcgggctgc cggtgcgcgc gctgcggaga gcgaagcgcc tcacaggtct
     8101 cctcctccgc tcgggatgag agccccgcat cccgacagca ggaaggcggt gacctcctcc
     8161 tggagacggg atccctgggg gcccgacagc acgttgtgtc cgccggaggc ttcgcggacg
     8221 acgaagtcct ctccctcgcg ccgcccgtgg gccgccagcc gtcggcgcag ttccagcgac
     8281 tgaccgacgg gaacgacctc gtcgcccgtt ccgtgcacca cgagcagttg tgcggtgatc
     8341 cgatcgaggc acgcctcagc ggtcctcggc tcgtgagccg agccggacgg ctggtggggc
     8401 cacgccccgt gccgggccag gaaggcccgc acggacgtgt tcgccatgcc gtgcaggctt
     8461 tccggggaaa ggaacggcgc gctgacggcg caccgtgacc aaagatgtgg gcggtgcgcg
     8521 gcggcgagaa gggcgagatg ggctccgtag ctctcgccgt acagcgtcat ggggggcatc
     8581 cccctgcgcc ggcgggccag cgcttcgctc atgcggagga cgtcatccag atcgggaccg
     8641 ccccaagccc cccgcacggc cagacggtgg gcggccccgt accccgtact gcctcgctgg
     8701 ttgggcgcga ccacggcgat gccggccttc gccagtcgcc ggaagaaggg ggagtggtcc
     8761 agcttccagg aagcctccgg tcccccgtgc agcgcgatca cgaggtggcg gctgacacac
     8821 cagtcccgcc cgccgtacac cacgacctcc atgtcgtcgt cggcaccggg gagcacctcg
     8881 gtgtgcgcaa ccgcccggcg acggggcaca cgtcgcgtcc gtgccggggg cgtgcggcgc
     8941 ggggcgatga cccacggacg ggagggttcg tccggtgtgc ttccgatgac ctgaagccgg
     9001 tccgtccacc gcgcggacgg aaggaagagg gcttcggcgt cgcccgcaac cttgacgggc
     9061 agcgccctcg agtcgaggct gccgcggagc aagcgggtcc tggcgccttc ggtgacgagg
     9121 agcagcaggt gccgggcatc gggggacagc gcgatcggaa ggggcgtggg accgcccgcg
     9181 gggtcgacca gggcggctgc gggcagcggt cgttcgacgc cgtcggtgac gaggaccagc
     9241 cgggtcccgg atgccgaggt cgacacgagg agagccgtct cggcgtccgg ggcggcgagc
     9301 agcaaacgac ccgtgccgtc cgcctcgggc gcgccctgcg cgccgcccgg agccgggggg
     9361 ttcgtgaggg gctcgacccg gcccgtgatc aagtcgatgc cgaccgggcg ggaccgtccc
     9421 tcctggagga ggtcgaaccc catgcgcaga ccgtgccggt ccagccgcgt accgttgcgc
     9481 agcatgccct ggaggcggtt ctgcggcacc accaggcgca gcttcgtgga atcctcggct
     9541 acggtccaga ggctcgaccc accctcttcg gtcgtgacgg cgacggccga ccaggacggt
     9601 ccctggccgg ccacgagccg tagagaaggg gcatcggacc gggccagggt ccgttcctgc
     9661 gcctcgtggt cgccctcgcc gggaccgagc aggacgatct cgtgccgtcc tccgctcgga
     9721 cgggtgagta cgaccctccc gtcgtcgaga gggacgagct gggtggccag tgactgaccc
     9781 ccggtggtga gcatgcgcgg cgtccggtcc gccgcgccgc cgaaccacga ctccacgccc
     9841 cacccgctcc gggtcagccg gaggcacgcg atgtgacggg cgtgatcgga gaaggcgaag
     9901 ctcttgcgat gaggctcctc actcacggtg gcctctgcga agcggctcgt ccgcgtggcg
     9961 ctcgtcggcc cactgagggg acggttcgcc gagtgcgtcg tcatggcgtc cctgcccggg
    10021 gcgtgggagc gagccggggc atgccgggga acggcgtggc gctgcggcgc ggaccgggca
    10081 tccacagccg ggctccgccg tgctccagcc gcatcaggaa ccccagcgct ccggagagcc
    10141 ccgtgccgta gtccgcggtc accgagtggc cgctctcatc ggtcacgaga ccgaggcctc
    10201 cgcgttcggc cctcaggacg tacatgacct cggccacgtc gcgtgccatg tgctgatagc
    10261 gcgcgtcacc ggtgagttga gccatgtcga cgaggaagtc cccgtcaccc gcgagcccgt
    10321 ggcaggccgc gttgccgacg ttccatcgag cccggtgcac cgtttccgcc gcctgccggg
    10381 atagatcgag cgagcggtcg tcgccggtga cccgccagag ccgtgcgagg aaggtcccga
    10441 cgccggatgc tccgctgcac cagtgctgca tgtcccgttg gccgtcctgt cgcggcgacg
    10501 ggccggcggg ccaacgagcc gcgccgcgcg acgtctcggc gaccgcgcac agcgtccgtc
    10561 ctgcttcgac tgcggcgtcg agataggcct gtcggccgga gaactgggct gcggccagga
    10621 ggaacgctcc cgctccggcg acgccgtggg cgaacccgta gtggaccaca ccggcgaggt
    10681 ccgagcggaa ctccgatggg atcggccaga ggatccggcc tttctccctg cgaccgcctt
    10741 ccaggacgcg atccgcacag gtgagcgcgg aggcggtcag ggagggacgg cccgactcgc
    10801 cgcccacgtg gagaagggcc atgcccgcgc cggacagtcc gtggcagatg tcggggttcg
    10861 gccagtcgag agcgacggtc tccagcatct ccacggcacg ggacgccagt tcctcgtcgt
    10921 ccaggaaccg ggcggcgtcg tagagggccc atgcggtgcc cgaacggccg aagtacagtc
    10981 ccggcagcga actcggaacc tcccgcgaac gtcgggcggt ccactcggcc acccgctgaa
    11041 ccgattcccg gtacgtggcg tcgctcaccg accgggcggc ctggaccaga acgccgagca
    11101 cacctgccgc gccgtgctgg acgttgcagg ggtcggtggt ggagccgaac tggcccgaca
    11161 tccacagacg gtcctcgtcg ggtcgcatcg tgttcagcag gtgctggaga cctccctcga
    11221 cgaggttctc ggtgtgactc cctgtcgctg ccgtggtctg agtcccgcag atgcgactcg
    11281 ggtccgccgg ggtggcgcgc gcatcgggct cggcacgacg cgcttcgtac ggtggtgcaa
    11341 cggagccggt gacggacgcg gagcgctcca agtgtgcgac cgcctgacgt atctgccacc
    11401 tgtcggtcgg ttcgtcggcg gtgagcccct tgatcacggg ggcgagtgcg cgaagcccgg
    11461 gctgactctc ctgcatcgcc tcgatcaagg cggtcctgcg gccctggccg gcctcggtgc
    11521 cagggctcgg cccgacgatc agagggtctc ggcccgtcgc caggaagaac agcaccatgc
    11581 cgagggcgta cgcgtcgaca ctgcgggccg gggcgggagc gaagcggggt gccgtgctct
    11641 gctcgggtgc gccgtaggcg ggcgtgtaca tccggcgtgc gggctcgccc tcggtgacgg
    11701 cgccctccag gtcgacgaga accacctcgc cgtcaggcgt gaccatgatg ttctgcgggg
    11761 tgacgtcacg caggacgaga ccaggcacgc cgtgtgcccg gtccagcagc gtcgcgacct
    11821 tcggtgccag agccgccacc tcgtggagtg gtacgcccgt gcccgtcccg gacgcgtgaa
    11881 catgatcggt ggcccagcgg cgcaacgtca cgcccgggac gtgttcctgc gcgaggaaga
    11941 ggcttccctg ttgctcgacg agcgccacgg tgcgcggggc gatacccagg ggggcgagcg
    12001 catcgaggat ctgggcctca tggcgcagga cgtcccgtgc gtcggtgccg tcgagacggg
    12061 cgtcgacatg tgggcgcgcg tgcttgagga ccacctccgc gccggtgcgc tggtccagcg
    12121 cacgatagac gccgccgcgg ttggcgtgct tgatcgcctt ggagacgcgg aaacgtccgc
    12181 ccacgagtac ggccgtcgtc gcatcccccg ccggccgagg gggaggtgcg tcgaagggag
    12241 gggacgaggc ccacgaaggg gggctgaacc atgctcgacg ctcgtccttg atgaggcttc
    12301 cgtccggagc acggaggagg aactcgaacg atccgtcagg cgtgagcgtc ggcttcgcgg
    12361 cgaacacgcc gtagcggaag tggacgaggc ttccgggagc gtacgggcgg tcggacagga
    12421 tgcgaggacc gtgaagatcc gaggtcgcgt cgtgcagtcg tcgggcgaga gcccggcatg
    12481 tctcgttgtc ctccggatag gccgtcagga acttgccgcc gtagccacgt ggctggttcc
    12541 ggtccaccaa ggtggtggcc ctgtcaaggt ctcgggcgaa cttgaagaag cagccggccg
    12601 agaggaggat ctcggctccg cgcgcgagaa cgaggggggc ggacagcgga gtggcggaca
    12661 ggtggatctt ccagccctgg tccgcagagg agtggcgcgg cgggacgaca cggcaccaga
    12721 agtcgtcctt ccgaagggtc cagccgccgc cgtgacgggc gacggctgcc tcggccaggt
    12781 ccgtcagaag cctgaggtcg gcgaggggct cacgcccggc cgccgtcttt ctgtgcatgt
    12841 tcgtcctttg cgtcacggtg gccgtcggag taccggtccg gagaccccgg tgcggcgtgc
    12901 gccgcaccgg ggaacgcggg gcccgcgtta cgggagcgtg ttctcacacg tgctgccgca
    12961 ggaaacggag cacgtgatct cacacggcca cagaccctcg atctgctcgt tgtcgagcgt
    13021 ctccagaagt tcgatgttgt cggacattcc tcctccttcc tcaaccgagg agagccaggg
    13081 ctcaggtgtc atccggtggt caggcctgcg tggccgtaca cgtgatcccg caggtcgccg
    13141 tgcacgtctt ctcgcagggc cacagaccct ccggctcgtc cgcgacgatc tcttccagga
    13201 agtcgacgtc aaacgtcatg gtgttcgttc accccctcac ctcatgcatg aggcgccctc
    13261 acagcgctcg acgctcctca gctaagacgt tgatccagat ctgagtgaga gcgttcatta
    13321 ctcaatcgcc gtgctccata gggcctttga gcgggccgat gcgtggcgtt cgcgcagctt
    13381 ccgcacccgt ccgggccgag cgaggaccgc ccggacgggt gtgcggaccc cgacgtgaca
    13441 ccaggcgccg ggcgcgctgc cggggcgcag cgggacaccg ccccacggct ccggccgcgg
    13501 cgtcagcgct ggatccccgc gtggggcatt cgaacgtcga aacgcctttc gcgggatttc
    13561 tcagagcttt ctcaggtcct tctcataaaa gattcccgag tagacgcggc gttacctgtg
    13621 atgcatggat gcccgactct tccggaactc gaactttaag tagagagtac tcaacgaatt
    13681 tccgctgcga gccgccctac tggaagcggc tgagttactg tgaggccatg aactcttggc
    13741 gcaacaagtt tccttgcctc cgctcaaaag gccgtaccgc cctcgctcta agcgtgttcg
    13801 gcgcttttgc cgttctgctg cctctcggtg aaatggcgac gcgtggatac gctacctgga
    13861 agatcgcttc cgttgccgag cggaggattc atacggatgc ggaagtcagc ctcgggtcga
    13921 ctccggcggt tctccagttg ggtagcggaa aattttccga cgtgaaggtg gaggcccgtc
    13981 aggctgattt cggaaagaat gtgaaggtgg acttcgttgc gcacctcatg aatctctccc
    14041 ggaactcttc cggtgcgtcc gttgaatcca gcaaggtgcg agccgaggtg acggaagagg
    14101 cgatgtcggc gtcacggtcg gcggaaggcg gcgggaacgt cgaagccgac ccggaaacag
    14161 gaacgcttgt ggcgcatgtc gggccgggtg gcggaatcga cataccgctc acgccgtcct
    14221 tggccgggga caaggtgacg ctcaccgcag gtgatccgac attctccgga aacccggtcc
    14281 cgagcggcct ggcggacatg atcaagagca aggcagaact gacggtggac atgtcggatc
    14341 tccctctggg actgaaggtg gacgcgctcg ccgtcacctc cacgggcctg cagctcgacc
    14401 tctccggcgg ccccgcaacc ctggaacagt gaacggcgcg ccgcacgccg ctgcctcgac
    14461 ggcgttcaga acgtggcagc gagcggggcg gccgccatgg ccgtgtacca gagaaccagc
    14521 aggcgatagg tggcgtcgtc actcgcagga ctcctcaagg tgacgacgcg cacggcagtc
    14581 gctgcgcaga tgaccgccgc cacggcctcg acccatcctc cggtccacag aacatgggcc
    14641 tcgaccagca gccggaccgc gaccggagtg agaaggaacc ctacgcacag atagatccgc
    14701 acggcccggg ctccgtagac gagaggaagc gtccggcgcc ccatgcaccg gtccccggcc
    14761 acgtcacgaa gatcctgcag cggcatcaac aacatcaaca atgccgagac cgcgatgacg
    14821 cacggcacga accgggcggg ttcgccgccg ccgacctgcc aagccgaaag cagctgaatc
    14881 ccggcctgga cgccgacgat gagcggtttg agaaagggcc gcttcgcgag accgagatgg
    14941 ttgttggcgc ccgccacgac gacccagagc agcgccagat ggacgatgcc gagcagccag
    15001 ccgctgaaga gcagtgccac ggtggcggcg gcgagccgcc accaggctcc tcgtaaggtc
    15061 agaaggccgg tgaccaaagg gcgcgacggt ttgttgacgc ggtcttcagg cacgcccacg
    15121 atctggttgg agagatcgaa gacgcagatg gccaacagga agtggacgcc tccgaagcac
    15181 accgatctga cgggttcggt gccggagaac cgtgcggccg ccaagatggt caccagcgcg
    15241 ggcagaagcg cgatcaggac gttcgaggaa accacggccg cgaaggtacg gacctctcgg
    15301 gtcgccgtgg aaacgacctc tcccaccagg cgctcgacac ggggaactcc ggacggcccg
    15361 gcaccctcgc ggacgtcccc gccaaggggt gaagcgagct gtcgggcacg gcggttcggt
    15421 aaggggtgca cgagattcct gaaacgagag gacgatgccg ggccaccggc ctgtccggcg
    15481 cggtcgcggt tccattcagc tatggaaccg gcccggaggg atgcgtgttt tgtactcaag
    15541 cgagcacatg ccggccccac cggcggtgac gctcgctctc gggctgaggg gcgcaccttg
    15601 tggcgagcgt cacatgaggg ggacggggcg cggagcagcg tttgacgatg cgggcgacgt
    15661 ctgggggagg acgggtcgtg aggggctgtc tgctccggcc gtcactgccg tcccgtcatg
    15721 gtgcggcagc accacggggt ttcaccgccc gcccgggtcg ctcgtcggag tggccgaagg
    15781 gcattgccag caaggacgac cggatcttcg gccacggtgt gcggcgtgcc acgcaccgtg
    15841 ttgtcgcctg gtctttcctt cttctgccgg aaggctaaga gatgagtgaa caacacaagc
    15901 ggggcaggct gcttgccgcc gccatggcgg cgctgatggt ggcgggcggt gccggcaccg
    15961 ccgtcgccgc tgcgacggcc gacggaagcc cgtccctgaa ggcgagcgcc gacgcgaagc
    16021 ccgtttccgt gcgtacggtc acgctggtga ccggggacca ggtcgtgctg acggggttcg
    16081 ctgggggcag ggaaggcgtg acggtgcggc ccgggccagg ccgtgagcac gtctcgttca
    16141 cctaccggtc gcacggcgac tcgctctccg tcataccctc cgacgccctg gagctgctgc
    16201 ggagcggagc ggtcgatgcg cgcctcttcg acgtgcaggc gctcgaggcg atggggtacg
    16261 acgacgcagc gcgagcgacc ttgcccctga tggtgcgcta cgacgccaca gaccgggggc
    16321 agggtgcccg gtccgccgtg agccgcctcg ccgcacccag gacgaccctc aagagcgtca
    16381 acgcggatgt ggtggccacc cccaaggcga aggccggcga ggcctgggag gccatgaccc
    16441 agaagcgggg aatgtcccgt gtgctggctt ccggcgtctc cacgatctgg ctggacgggg
    16501 cagtgaaggc ctccctcgac aagagcgttc ctcagatcgg agctccggac gcctggcacg
    16561 acggactgac cggtcgtggt gtcctcaccg cggtgctgga caccggcatc gatccggcgc
    16621 acccggatct ggcggacgcc gtcgtgacgt cgcaggactt cacggggagc gcgaacggga
    16681 ctgcggacgc tcacggccac ggcacccacg tggcctccat catcaccggt gacggcagtg
    16741 catcggccgg ccgatacgcc ggagtcgccc ctgacaccaa gctgctggtg ggcaaggtgc
    16801 tcaacagcaa ggggcagggg tccgaatccg ggaccatcgc cggcatggaa tgggcgacca
    16861 gccacggcgc caaggtcgtc aacatgagcc tgagcgcgtc cgccacggac ggcacggacc
    16921 ccatgtccca ggctgtgaac agcctcaccg cctccaccgg agcgctgttc gtcgtcgcgg
    16981 caggcaacga aggcgtgaac gagaaggtca gcagccccgc atcggcagac gccgcgctcg
    17041 ccgtcggagc ggttgacgcc gacgaccagc tcgccgactt ctccagccgc ggcccccgcc
    17101 tcgtcgactc ggccgtcaag ccggagatca ccgcccccgg cgtgggaatc gtcgccgcac
    17161 gggcggcagg cacgtcgcac ggcgacgtgg tcgacgacca ctacaccaag ctcaacggca
    17221 cctccatggc gactccgcac gttgccggag cggccgcgct cctcgcgcag cagcatccgg
    17281 actgggacgc cgcacggctc aaggacgcgc tgacgagcac cgccaagccg acggccggcc
    17341 tggacgtctt cgcccaggga gccggacggg tcgacctgac ccgagcagta cgccaggacg
    17401 catacgccac cccgggtacc ctgtccaact acctgaagtg gcctcacgcc actccggtga
    17461 agcgcaccgt cacctatcac aacgacggtg acgagcccct gacgctgagc ctcgacgtca
    17521 cactcgacgg aagcggcgag aacggccggc tgatcacgcc ggacgcggat cagctgaccg
    17581 tgccggccca cggcaccgcc gcggcccagc tcaccatcga ccccgcccag gcggacgccg
    17641 gcacctacag cggggtgctc accgcacgga gcgcggacgg tcagaccgtc gttcgcaccg
    17701 ctctcggtgt gttctccgag gacgaggtgt acgacacgac gatccgtctc accgaccggg
    17761 ccggagagac gctttccccc gccctcctgc agctgatcaa cctcgacacc ggggagggat
    17821 tcgacgcccg cgccgtggga gacgcgctcg tcggccgcgt cccgaagggc cgctacaccg
    17881 ccaacgcggt catcttcaac tcgaccggaa gcgtacagag cgccaccctc gtctcccagc
    17941 cggacgtggt ggttgcaggc gacacgaccg tcaagctcga cgcccgcgca ggaaagatcg
    18001 tgcaggccga cgtgggcacc gagacccagg cggacacccg gtgggtcggg atcaacgaga
    18061 cgatcgccgg cgttctgaac gagttcaggg tcttcaccca ggaccccgag gccgtgctgt
    18121 acgccgcggg cacccctgcg gtgacctccc gcccctacac gttcgtccac ctggcagccc
    18181 tgcatgcccc cgccgtcccc ggcaggcctg aagcggccta caacctcgcg ctcacccgtg
    18241 acggcgggat ccccgccgat cccagtttcc aggtccgcag cgacgagctg gccaaggtgc
    18301 gcgtccgcta ccacacgcaa ggcgatccgg cgcctgccca ccggtccaac ctggcgtcct
    18361 tcgacggcag cgcccgcgcc tcgggcggag gctacaacgt caagctcgcg agtgagcaca
    18421 ccgaatactt caccgccacg aaccgcgtga agtggctcgg cgcactggac accggtacgt
    18481 cattcgagac cagcccactg acgcagtaca agcccggcaa cgccaccacg gaagagtgga
    18541 acaaggcagc catcagcccg gccgcgccgg atgccggacg ctgtgagaac tccctcttcg
    18601 cgcccatcca ggctttctcg acgtcggccg ccggccacct tgccagcgct ttcgagtaca
    18661 cgggcacagc cacgctgctg agggacggag aggagatcgg cactaccgac gacccccagt
    18721 tcgccttctt caccgacctg cccgccgggc cttctcgata caccctccgc ctggcggcac
    18781 accatgacac tcccgcggtg gccctggcga cgaaggtcga cgccgaatgg accttctcct
    18841 ctgccgagcc cgaagaaggc tgcgagaagc cccagaagct cccgctgctc aacacgcgca
    18901 tcggcgcggg cttcgacctg aacaacagtg ctcccgcgga caagcccctg cccgtgacca
    18961 tcaaggtgga acgtgccgac gcagagaccc ctgccgtcaa ggcgttgtcc ctcgagacga
    19021 cgttcgacga cggcgccacc tggcacaagg tgcccgtgaa gagcaccgga tcggcctcct
    19081 tctccgctgt cgtcccgccc gtcgctgccg gcaacggcta cgtcggactg cgcacgacgg
    19141 ccacggacac cgacggaaac gaactgaagc agacggttct ccgcgcctac cgactgcgct
    19201 gagtcgaaac caaggccgcc agcctcgtcc acgcgttgga cagcgggtgt gtccgttgag
    19261 ggctggcctt gctcgactgt cgatccgtcg ggcgacgtgc tcgacggaaa cgacagagcc
    19321 cccgcacttc ggtgcggggg ctctgccggg aactcggccc tcgcaaccac gacgagagac
    19381 agccgcagca ggccaacggc cgggtccggt cgtcctgatc agccccgagg agggtgctga
    19441 cggcgaggtc gggggcggcc cggtgacgga tgaggagcgg cctccggtga ggagaacccg
    19501 ccgggcaccg cggcgcgctg cctcggctgc tccacgggag cgggcacggg gttgagcagg
    19561 gcgggcctgg ccgtggccag aacagcgatg tgggggatgt tccgggcgca ggcctggcag
    19621 acctctgcca gggtccagac ctgtccgacg gccgggttgt ggacgaggac cagcagactg
    19681 gtgccggcgc agtggacggg cgtctcgtgg aggccgcaat gcgcgctgcc gcagctgcag
    19741 gcggcgttgg ggcgggcacc ggcgaggcgt ccgtgagctc tgacgtgttc cgccggaaac
    19801 ggcgcatgcc ggcagcgtcc ttcgagcggg gcggcatgcg gcacccgatg gtgctgcagg
    19861 taacggacac ggtgtggtcg gggtggccgg tgaggcggac cgtccaggtc cgtcccggca
    19921 cgcgtgctcc gggcatcagg gtcacgtcgc gtcctgtcgt tgtgcggttg gtggctggct
    19981 cgtgcaagag ccggggtgcg cgccgggtcg cggaggacaa cctgccagca gcgcggggcg
    20041 tccgggggca gagcgcgcgc agggcgggga ccacttcggc cgaggatagc cgcgctgttg
    20101 ctctgatccc ctcgtacgcc gcgctgtgcg gcacggcact cggcccctcg ggcgcgccac
    20161 cgatccgcgg acggccgctg gcgattcggt gcgtcggaga cgtgtcgttc caggcggtgg
    20221 cgtgtgcgac gccggtcgac gaccaggccc gacgtatccg tcataaccgt tgtgtctact
    20281 gcagtgcttt cagggcgctg ctgaaccgct cgtactcgga gtcaccggtg ggcagcaggt
    20341 ttgactgaac cattgccatc ccgatcttga gctcgatgtc gtcgtcgtcg cactcaagcc
    20401 cgcactggat gatctcggca atcatttcag ttgtgccggc cttgaagatc gagccgctgt
    20461 cgccctggta gagccaggcc tcgaagacga cgaatccatc agttgccaca tcccagagtt
    20521 cgcaggaatt gagcacggac tcaagctctg attcatcgtg ggatgaaatg cgctcctccg
    20581 ggggcaggtc ctggccatcg taggcaattc cagacagcct cagctgttca agctgcgtgg
    20641 tgttcagtcg atccaccgac gtaattttgc gcatgcctgt gaactcattc atgaaggaat
    20701 gctagcagcc tgttcccgag ccgcccccgc gcagtaataa aacccagaag agatctgtct
    20761 cgggcatctt cggcagattg tcttgcggtc cccagtggtg agaagagtat gtgctactca
    20821 ttctctgccg catgcggggc aaagtggttg accagccgtc ggcatgacgt acgaagggcg
    20881 ccttgtctgc tgttgtgttg agcgagaaac ttcttgtgtc gaagtccctc caccgacgca
    20941 accagttcac ccacccgaac aaggatccgc ccgtgacccc tgatcaactt ttcgacgaca
    21001 tcgctgccga ccttgcccac tgcggcgcca ccgccggcgt catgttcggc aagcgcgccc
    21061 tcaaggctca cggcaaggcc ttcgcctgcc tcaagggcga ttccggcgcg ttcaaactcg
    21121 gcgaaggaac caccgttcac gttgaggccc tcgcgctcac tggagcggag ctctttgacc
    21181 cgtccgggaa gcactgtccc ttcaaggact gggtcgtcgt cccccacgcg cacgccgcgc
    21241 agtggctcaa cctggccgca gccgcactga acggcatcag ttcacaaccc gagtgccgag
    21301 cgagtgcggt ctggacgagt acgaggtccg ccgctacatc ggctggtatc ggcacatcac
    21361 cctggccatg ctcgcccacg ctttcctcgc cgggcttgcc gccgaatgca gcaaaggctg
    21421 tgaaacgacg ccaccagcat tgttgccctc accgtggcag agatccgccg gctcctggaa
    21481 catctcctgc ccccaaccag aacccggcgc gatcctcgac atcacgcaat gaactggtcc
    21541 cactggcgac gacatcggca agcagttgct cggcgctgtc actaccaaag aagaaccagc
    21601 tcaagaaacg atccgctgct ggagtactag ccacggctga acgcgaacgt cttcgaaggg
    21661 cagctctgcg gggccgtgcg gttgctgcta gaggacgcgg tgtacaaggc ctttgacagg
    21721 ctggttgacc tcgttgtcgt cgtgtggggc ctcgatcggg ccgatccgtc tcagccagcc
    21781 gatcgcggcg agcgctgcga ctccggccag tagcaggcta agttcgtcga tgtcggggta
    21841 ttcgccggtc gccggcttag cgttctccac acgccactca acccccggcg accgcgctaa
    21901 ggcacgcgac gatggtcgac accgtcgcgg cgagcgccgc cgacttcgga ggtccggttg
    21961 cggcaccaga caggcgtccg catcccaagg gcggtcttca cgggcggatc gtcgttcatg
    22021 tcggcgagtt ctccctggtc agaaaccaca tgcatgttga ctgcggagcc gtcggtctca
    22081 ccaacagcca cacggccaac ctcacggtcc tcctgcttcc ctcgaacggg ttgtactcgt
    22141 gtccccgcgc taagggttgt cccgcaaaga tctcgggggc ggaacttgtg gctgacgagc
    22201 gggcgtacgg gctttcggca tggccgcaga cgaacctcgg caaggctacg gagctgttgc
    22261 gtcaggctgt tgccgagatc agcgtttccg atcagggagc tcttcgagtc ctgttcgcgg
    22321 gcggtttggc ttgctggtgc cgatcaatga cgagcggtca gcatggtcag tgacggtcct
    22381 cgaccatgga gttctcaccg ccaagcccgg cggcggggtg gcagtaagcg atcccggctc
    22441 cgagacgtag tccggcctcg tttgatgacc cgggcttcga gcgaggaccg gccctgatcg
    22501 atgatcatga tgtggcgagt gtgatcacgg catcggagcc gtcttggata gccccattcg
    22561 cagggctgag cccgcgctgc ttcagcgaac tgctgacggc gttgcggcgc gatggagcag
    22621 atgtgatcca ccgcggtcgg ccgtggagtc tgccgctgga ggatcgggtg ctgctggtca
    22681 cggcctattg gcgtaccaac ctgacgttgc ggcagctcgc tccgctgttc ggcgtctcga
    22741 agtccacagc tggccgagtc atcaaccacc tcgggcccct gctcgcgctc cggccccgca
    22801 agcggttcgc gaaggacgcc gtgctcatcg tggacggcac tctggtcccc acccgcgacc
    22861 acgtcatcgg cgagcgttcg aagaacgacc ggtactccac caaccaccag gtcgtcatcg
    22921 acgccgacac ccggttcgtg gtcgccgtcg gccggcccct gccaggcaac cgcaatgact
    22981 gcaaggcatg ggagctgtcc ggtgcgaagg ccgccgttgg cagggcaacc gtgatcgctg
    23041 acggcggtta ccgcggcacc ggcctgatca tcccgcaccg ccgggaacac ggtcaggccg
    23101 aactaccagc ctggaaagag gagcacaacg cttcccaccg caaggtccgg gctcgcgtcg
    23161 agcatgcctt cgcccgcatg aaggcgtgga agatcctccg cgactgccgc ctcaagggcg
    23221 agggcgttca ccacgccatg cgcggcatcg cccgcctcca caacctcgcc ctcgtcgggt
    23281 aagacacagc gccgctggtt gattggcacg ccgcagatca tttacgggac agcccttagg
    23341 cactgggtgg ttggtgcctt tcggcgttct ggtgggtgga tggccgcctt gcagcgcgca
    23401 ttcgctcaac tcctggccac cgcaacccac tccgcaacgc agcgtctccg agctccagaa
    23461 cgagggcgac caggcccaac gcctcgcact gtgcttcatc ggcgtcgtcc gcctgcacaa
    23521 gaagagccat ccgcacgcac ccggtggtcc gatcagggct gtacgcctca ccaccccggt
    23581 ttccgcgttc gacggttagg tacccgacgc cgccccgccc tgagcgcgcc ttcatcagct
    23641 ccgcactcaa ggagaccgac tgctctttgc tccagtcgcg tgctacagcg tgcgcagtgg
    23701 taacgaatct gctggtcaga gcccgattca aatcctaggg gtatgcctag gggggtatcc
    23761 ctggcgcccc ttctgtgcgg cattggaatc gttgtccgtg taagggctca gcatgagtga
    23821 gtggtctctg aaggacagga gggatcctgg tgtttaccgc cccgaagatc atggtcacat
    23881 tcggtgaatc gcacggccgg cgtccagcta cggcgcgtgg cgcctccgtc cgaccggtaa
    23941 aaatccctgc gccgaggccg ccaagcgacg acaaggcatg gccgctcgag cacgtacccc
    24001 agtctgtccg cacggctcga aggatcgcca cgcaggcttt gacggcatgg gaggtaccgg
    24061 aagaggcaca acagatcgcg ctcctggtgg tttccgagtt ggtgaccaac gcggtcgagc
    24121 atgctcaggc acccatggcc ttgcacctac accgccgacg tgcagaaaga gagctgtgga
    24181 tcggcgttac ggatggcgga ccggccgaag tggaaggcgc ctggaccacg tcctgcaccc
    24241 ctgatgaaca cggccgcggc ctagccctgg tcgattcgct gacggaagat cacggcacat
    24301 acagccatgt gatgccccct gccaccacgc actgggcccg cctgcccgct gcggtctgaa
    24361 caagaacccg gctctcgtgc gtggtcgtga gaggcgggat ccccagggct tcggggattt
    24421 cgccccagac ctcgtcggcc cggatggcgc cactggaacg ccgccaacgg atcagaagcg
    24481 ttcggagttg agcaccagac tcgcccagaa cgatgcccaa aggtctctca acagtccgct
    24541 gctgtaaaca acgaaaagaa ccgcgccaat aggtcagaca ctgtctggtg tccgacccgg
    24601 aatcgatcgg gccaggacac cagacgaaga tccacagcca cacatgggca gttccgattt
    24661 tcgaatccgc gatgatcgtg gagtctccgg agccgtacgg cgatcgtcga gtgggagccg
    24721 tcaatcatcc ctgtcgcagc ggcagtcggc gaacaccctg ccagtggatt ctttgagacc
    24781 tcaagaattg gaaaggcatt caatccgtgc gctttacatc tcaccagata tccatcgcgg
    24841 tgatcgccgc tgcttcggcc tcgatcttca ccgctaccac cgtggctgct gcgccccttg
    24901 agacgtggga cgccgttgct gcctgcgaaa gcagcggcga ttggagtgcc gtcagcccta
    24961 gcggataccg tggtgggctg cagttctcgc agagcacatg gcaggagttc ggcgggaccc
    25021 agtacgcccc gaccgcagac aaggccacga aagagcagca gatcatcatt gccgaaaagg
    25081 tccttcaaga ccagggaccc ggtgcctggc cagtctgctc agtcaaggct ggactggccg
    25141 gtagcatcgc cactgcgccc tctgaagagg aggtaccgag ggcctcctcg acgcagacag
    25201 cagcccctgc aatcgtccaa agggctcaag tccctttcgc cacctacaag gtgcagccgg
    25261 gagatacatg gaact
//
