LOCUS       NZ_LIVV01000005        10414 bp    DNA     linear   CON 28-MAR-2024
DEFINITION  Streptomyces sp. CB02009 scaffold5, whole genome shotgun sequence.
ACCESSION   NZ_LIVV01000005
VERSION     NZ_LIVV01000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CB02009
  ORGANISM  Streptomyces sp. CB02009
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 908521)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 908521)
  AUTHORS   Yan,X., Ge,H., Hindra,F., Yang,D., Huang,T., Crnovcic,I. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-AUG-2015) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC Genomics Workbench v. 7.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905825.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:41:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,214
            CDSs (total)                      :: 8,139
            Genes (coding)                    :: 7,984
            CDSs (with protein)               :: 7,984
            Genes (RNA)                       :: 75
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 51 of 155
            Pseudo Genes (incomplete)         :: 117 of 155
            Pseudo Genes (internal stop)      :: 15 of 155
            Pseudo Genes (multiple problems)  :: 26 of 155
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:06:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 118538
            Orig. end                         :: 128952
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LIVV01000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10414
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="1"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10414
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10414
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5414](+)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5414
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     misc_feature    1257..1272
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.5"
                     /tool="antismash"
     misc_feature    complement(1569..1584)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.27"
                     /tool="antismash"
     gene            1910..2611
                     /locus_tag="AMK27_RS19985"
                     /old_locus_tag="AMK27_19700"
     CDS             1910..2611
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015267 - channel activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017239820.1"
                     /locus_tag="AMK27_RS19985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_19700"
                     /product="hemolysin III family protein"
                     /protein_id="WP_073909921.1"
                     /transl_table=11
                     /translation="MTAATPDVPPIEPDPIGQTPSLPLKPRLRGWLHAGMFPAVIVAGL
                     VLVALSDSPRARIACGIYVLTACLLFGISALYHRGDWGPRGEAVLRRLDHANIFLIIAG
                     TYTPLTLLLLPDSTGRPLMWAVWAAALAGIAFRVFWVGAPRWLYTPCYIAMGWAAVFFL
                     PDFMRAGGIAVLVLVIVGGLLYSAGGVIYGIKRPNPSPRWFGFHEVFHSLTLAAFIVHY
                     VGISLVAYQHA"
     gene            complement(2653..3675)
                     /locus_tag="AMK27_RS19990"
                     /old_locus_tag="AMK27_19705"
     CDS             complement(2653..3675)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015035843.1"
                     /locus_tag="AMK27_RS19990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_19705"
                     /product="glycosyl hydrolase"
                     /protein_id="WP_073909925.1"
                     /transl_table=11
                     /translation="MSRHLPGPRAALVVLLAAVLVLLLPYDRIAPGDRHTGTRAEPEPD
                     PAPLPGVPSGFFTGSDEAGVRRIAQAQAWLGGESLTVGHTYLPGDRWSNIEGHPALFGP
                     WARWKEARPGRLFVLNVPMMDRSEAGLPDTEVRAGLRSGAAGAFDGHFRTLGERLVDHG
                     LGDAVLVLGWEMNGTTYSHRCGPDPEAWKAYWRRVVEVLRGVAGQRFRFDFTPSRGRDA
                     VEWPRCYPGDDVVDIIGMDAYDQPAGLSFEDQVAEEYGLAHHVRFAAAHGKPVSYPEWG
                     LFRNGDNPAYVRGMLDWFAAHRPVYQTVTDYCPHGVWGCAGNPESARVVRNALGGPAGP
                     "
     gene            complement(3677..4330)
                     /locus_tag="AMK27_RS19995"
                     /old_locus_tag="AMK27_19710"
     CDS             complement(3677..4330)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017239817.1"
                     /locus_tag="AMK27_RS19995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_19710"
                     /product="vitamin K epoxide reductase family protein"
                     /protein_id="WP_073909929.1"
                     /transl_table=11
                     /translation="MATVNVRGGVPEQRQEREESARETAGTIGGSRALAWMLMITGAAG
                     VLAGWVITIDKFKLLEDPGFQPGCSLNPVVSCGNIMKSEQAAVFGFPNPMLGLVTYAVV
                     VALGAGLLAGARYRGWLWLGLNAGMLFGVGFCTWLMYQSLYEINSLCLWCCLAWVATIV
                     MFWYVTAHNVRHGVIPAPAGVRTFLGEFTFALPVLHIGIIGMLILTRWWEFWTS"
     gene            complement(4349..4852)
                     /locus_tag="AMK27_RS20000"
                     /old_locus_tag="AMK27_19715"
     CDS             complement(4349..4852)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889043.1"
                     /locus_tag="AMK27_RS20000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_19715"
                     /product="DUF5949 family protein"
                     /protein_id="WP_231072103.1"
                     /transl_table=11
                     /translation="MTTSNVVSSARSASPLGTLTVIPWASEPSADAPGTPFLMAYSLGD
                     GRDGPEAGQQAMRTALEAMGLSVGDRLFDLDKDAGITASLLVEGGSAVLNLPFLKVQCP
                     VPDEWQEAARERGQVYLICSVRPWPEAVPGQPVDEARLRAFVSDEEMLKESAHVLMPVR
                     RLQG"
     gene            5001..5414
                     /locus_tag="AMK27_RS20005"
                     /old_locus_tag="AMK27_19720"
     CDS             5001..5414
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0042438 - melanin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017239815.1"
                     /locus_tag="AMK27_RS20005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_19720"
                     /product="tyrosinase family oxidase copper chaperone"
                     /protein_id="WP_073909935.1"
                     /sec_met_domain="melC (E-value: 7.7e-38, bitscore: 125.5,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVPRRLVLRSLFALAVTAFTGGALGRVTTRPPSGAPAERARDPH
                     AFDEMYGGRHLLGFSGPEGGPVALVDGRPLHLMRCADGGFVTPIDHYESCPTPLAAVRA
                     AVDELGTARLSPLAAAHGVHTDPTGGSPRGVHA"
     gene            5398..6264
                     /locus_tag="AMK27_RS20010"
                     /old_locus_tag="AMK27_19725"
     CDS             5398..6264
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017239814.1"
                     /locus_tag="AMK27_RS20010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_19725"
                     /product="tyrosinase family protein"
                     /protein_id="WP_073909939.1"
                     /transl_table=11
                     /translation="MVYTRKNQRDLTGAERRKFVAAVLELKRTGAYDRLVRTHIDHYTA
                     DGEGRLRVAHMTPSFLPWHRKFLLEFETALRRIDPTVSVPYWDWTRDNSPASSLWGEDF
                     LGGNGRRADLQVMTGPFAHSAGRWTITQSMTDERFLTRDFGRPRDPIALPTQAQLDEVM
                     RERVYDVTPWNSTSASGFRNRLEGWAPGRGNERFRIHNRVHRWVSGLMLGGGSVNDPVF
                     WLHHAFVDLVWSRWQQRNPGAAYLPAEPPPLGDAQYRKVVARHEPMAPWGVTPASMFDH
                     SRIYRYA"
     gene            complement(6363..6638)
                     /locus_tag="AMK27_RS20015"
                     /old_locus_tag="AMK27_19730"
     CDS             complement(6363..6638)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015035838.1"
                     /locus_tag="AMK27_RS20015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_19730"
                     /product="chaplin"
                     /protein_id="WP_030324043.1"
                     /transl_table=11
                     /translation="MSRIAKAAAVLAGTGAVALSGAGLAVADSGAEAVAAHSPGVASGN
                     VVQVPVHVPVNLCGNTVNVIGLLNPAFGNTCINADGHDNGDGGYGG"
     misc_feature    complement(6855..6866)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.17"
                     /tool="antismash"
     gene            complement(6994..7506)
                     /locus_tag="AMK27_RS20020"
                     /old_locus_tag="AMK27_19735"
     CDS             complement(6994..7506)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015035837.1"
                     /locus_tag="AMK27_RS20020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_19735"
                     /product="hypothetical protein"
                     /protein_id="WP_073909942.1"
                     /transl_table=11
                     /translation="MTLRSHAGMGLLMTAFASAALAAPASAVEAPVIVPLQGLDPVLPM
                     DAPTVATGVPVPMPGAPTGFQKGIGSLPDLALPSVPLTGTLPATVVDAPLPEVVKDSEP
                     GRALFATPHSEMAAATPGAVVGNPVVAPDGDGLGGLPELAKPRVGMLPPMVSGTLDSQL
                     GLAPEAR"
     misc_feature    7504..7518
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.6"
                     /tool="antismash"
     gene            complement(7624..8463)
                     /locus_tag="AMK27_RS42370"
     CDS             complement(7624..8463)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK27_RS42370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_143204870.1"
                     /transl_table=11
                     /translation="MRSIISRKVLTAAAATGILSLSGGFALAASTHAGTGDGPGPGSAG
                     HVQAPLPADVCGKSRELGGYVAAAVGDLCDQAEDPDGYGDEPGEPTHPGEPTHPGEPTH
                     PPTHPPTHPPTHPPTKPPTTPPTKPPTTPPTKPPTHPPTTPPTTHPPTHPPTTPPTKPP
                     TKPPTTPPTKPPTTPPTKPPTHPPTTPPTTHPPTHPPTTHPPTHPGECEEPAPGQEPEP
                     GCEEPTTHPTTKPPTGPPELPETGSETALMGAAAISAALIVGGTVVYLRGGRVARRH"
     misc_feature    8603..8617
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.82"
                     /tool="antismash"
     gene            complement(8719..9000)
                     /locus_tag="AMK27_RS20030"
                     /old_locus_tag="AMK27_19745"
     CDS             complement(8719..9000)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017239811.1"
                     /locus_tag="AMK27_RS20030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_19745"
                     /product="hypothetical protein"
                     /protein_id="WP_073909948.1"
                     /transl_table=11
                     /translation="MKPTKVAAVVAGSLMALGAAAPAMATEALTPTSLNGGLEAIAANG
                     LKSDVLSSTTDGSPVKTVTDTATQLNETTKGGSLLGGLPVGGGLPLGG"
     misc_feature    9070..9087
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.77"
                     /tool="antismash"
     gene            complement(9262..10092)
                     /locus_tag="AMK27_RS42375"
                     /old_locus_tag="AMK27_19750"
     CDS             complement(9262..10092)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006382606.1"
                     /locus_tag="AMK27_RS42375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_19750"
                     /product="hypothetical protein"
                     /protein_id="WP_073909951.1"
                     /transl_table=11
                     /translation="MRPLATRRITALAISAVITLGTAGPAIAGEHHPTTAAERAARAPL
                     PDVAALLAQAEALGELGSVTTPVTELVTAALKADSGQLPAVDAEALKAEIAAAVEEAKA
                     TAPAPLPDAPVTPPSTGLPVTPPSTDLPVTPPSTDLPVTPPAAELPVTPPVTLPVAADA
                     NAAWAGKAAAPADVVDDALATVEKAVAALLAAVTSGDAGGVVPQVTATLTSLVNLAVST
                     VLGSGLPAPDLAGLPALPALPVTTPELPAAPPELPAAPPAAVPELPAAPALPVR"
ORIGIN
        1 ggaactccag gtcctcggcc ggcaggtcga ggccctcggt gtcgagggac tccgcggtcg
       61 gcaggatgcc gatcggggtc tcgacgccct cggccttgcc ctccaggcgc tcgacgatcc
      121 acttcaggac gcggctgttc tcgccgaagc cgggccagac gaacttgccc gcgtcgttct
      181 tgcggaacca gttcacgtag tagatcttcg ggagcttcgc ggcgtccgcg gtggcaccga
      241 ccttgaccca gtgggccatg tagtcgccca tgttgtagcc gcagaacggc agcatggcga
      301 aggggtcgcg gcgcagctcg ccgaccttgc cctcggcggc ggcggtcttc tcggaggcga
      361 cgttcgcgcc gaggaagacg ccgtggttcc agtcgaagga ctcggtgacc agcgggacgg
      421 cggaggcgcg gcggccaccg aagaggatcg ccgagatcgg gacgcccttg gtgtcctccc
      481 actcgggggc gatcgtcggg cactgcccgg ccgggacggt gaagcgggcg ttcgggtggg
      541 cggccggcgt ctcggactcc ggcgtccagt cgttgccctt ccagtcggtg aggtgcgcgg
      601 gggccgtctc ggtcatcccc tcccaccaca cgtcgttgtc gtcggtgagg gcgacgttgg
      661 tgaagacgga gttgccccag agggtcttca tggcgttggc gttggtgtgc tcgccggtgc
      721 cgggcgcgac gccgaagaag ccggcctcgg ggttgatcgc gtacaggcga ccgtcctcgc
      781 cgaagcgcat ccaggcgatg tcgtcgccga tggtctcgac ggtccagccg gagatcgtgg
      841 gctccagcat ggccaggttg gtcttgccgc aggcggacgg gaaggccgcc gcgacgtact
      901 tcgcctcgcc ctgcggcggg gtgagcttga ggatcagcat gtgctcggcg agccagccct
      961 cgtcacgggc catgacggag gcgatgcgga gcgcgtagca cttcttgccg agcagggcgt
     1021 tgccgccgta gccggagccg tacgaccaga tctcgcggct ctcggggaag tgcgagatgt
     1081 acttggtgga gttgcagggc cacggcacgt cctcctggcc ctcctccagg ggggcgccga
     1141 gggtgtggac ggccttgacg aagaagccgt cggtgccgag ctcgtcgagg acggcctgtc
     1201 ccatgcgggt catggtgcgc atggagacgg cgacgtacgc ggagtcggtg atctcgacgc
     1261 cgatggcgga gagcggggag ccgaccgggc ccatgcagaa gggcacgacg tacatggtgc
     1321 ggccacgcat cgagccgcgg aagatgccct tctcgcccgc gaaactgctt ccttctccgg
     1381 taaagatggc cttcatctcc gccggggcct tccagtggtt ggtcgggccc gcgtcctcct
     1441 ccttctcgga gcagatgaag gtccggtcct cgacgcgcgc gacgtcggtc gggtcggagg
     1501 cggcgtagta cgagttcggg cgcttcaccg ggtcgagctt cgtgaaggtc cccttggcga
     1561 cgagctcctc gcacaggcgc tcgtactcgg cctcggagcc gtcgcaccag acgatgctgt
     1621 ccggctgggt gatctcggcg atctcgttca cccaggagac gagcccctgg tgctgggtcg
     1681 gaagggtctg gggagccgcg ttgtcgcgcg ccacgattgc tccttgtaga ggggtttttt
     1741 ggtgtgtgcc ccgtgggggc cgcgacccgg acgcttcgta gctgctcatc cggtgccgac
     1801 cgcactcatt tgatcatccg acggatccgc ccatatgtcc aggggcacgc acacgtgagc
     1861 atcgccactc acatccagga cctacggggc cgtaggtacg attccgttca tgactgcagc
     1921 cacgccggac gtgcccccga tcgagccgga tccgatcggg cagaccccgt cgctcccgct
     1981 gaaaccccgg ctccgagggt ggctgcacgc gggcatgttc cccgccgtga tcgtcgccgg
     2041 cctggtcctg gtcgccctct ccgactcgcc ccgcgcccgc atcgcctgcg ggatctacgt
     2101 cctcaccgcc tgcctgctct tcggcatcag cgcgctgtac caccgcggcg actggggccc
     2161 gcgcggcgag gccgtgctcc ggcgcctcga ccacgccaac atcttcctga tcatcgcggg
     2221 cacctacacc ccgctcaccc tgctgctgct ccccgactcc acgggccggc cgctcatgtg
     2281 ggcggtctgg gcggcggccc tcgccggcat cgccttccgg gtcttctggg tcggcgcccc
     2341 tcgctggctg tacacgccct gctacatcgc catgggctgg gccgccgtgt tcttcctgcc
     2401 cgacttcatg cgcgcgggcg gcatcgccgt cctcgtcctc gtcatcgtcg gcggactgct
     2461 ctacagcgcg ggcggcgtca tctacggcat caagcgcccg aacccctcac cgcgctggtt
     2521 cggcttccac gaggtcttcc actcgctgac gctggccgcc ttcatcgtcc actacgtcgg
     2581 catctccctg gtggcctacc agcacgcctg accggacacc ggcaggacac ccgcgaacgc
     2641 gggccggctc cctcagggac cggccggccc gcccagcgcg ttccgcacca cccgcgccga
     2701 ctccgggttg ccggcgcacc cccacacccc gtgcgggcag tagtcggtga ccgtctggta
     2761 gaccggccgg tgggccgcga accagtccag catcccccgc acgtacgccg ggttgtcgcc
     2821 gttccggaag agcccccact ccgggtacga gaccggcttg ccgtgcgccg ccgcgaaccg
     2881 cacatggtgg gcgagcccgt actcctcggc cacctggtcc tcgaaggaga gccccgcggg
     2941 ctggtcgtac gcgtccatcc cgatgatgtc gacgacgtcg tcccccgggt agcagcgcgg
     3001 ccactccacg gcgtcccgcc cccggctcgg cgtgaagtcg aagcggaacc gctgccccgc
     3061 caccccccgc agcacctcga ccacccgccg ccagtacgcc ttccaggcct cagggtccgg
     3121 accgcagcga tggctgtacg tcgtgccgtt catctcccag ccgagcacca ggaccgcgtc
     3181 tccgagcccg tggtccacca gccgctcgcc cagcgtccgg aagtgcccgt cgaaggcccc
     3241 ggcggcgccg ctccgcagcc cggcccgcac ctcggtgtcc ggcagccccg cctcgctgcg
     3301 gtccatcatc ggcacgttga gcacgaagag ccgccccggc cgcgcctcct tccagcgcgc
     3361 ccagggcccg aagagggccg ggtggccctc gatgttggac cagcggtcgc ccggcagata
     3421 ggtgtgcccg acggtcagcg actcgccgcc gagccaggcc tgcgcctggg cgatcctgcg
     3481 cacaccggcc tcgtcggagc cggtgaagaa cccggacggc accccgggca gcggcgccgg
     3541 gtccggctcg ggctcggccc tggtgccggt gtgccggtcg ccgggggcga tccggtcgta
     3601 gggcagcagg agcacgagaa cggccgcgag cagcacgacg agtgcggccc gcggcccggg
     3661 gaggtgacgg ctcacgtcag ctcgtccaga attcccacca gcgggtcagg atcagcatcc
     3721 cgatgatccc gatgtgcagg acgggcaggg cgaaggtgaa ctcgccgagg aaggtccgga
     3781 cacccgccgg ggcggggatc accccgtgcc ggacgttgtg cgcggtgacg taccagaaca
     3841 tgacgatggt cgcgacccag gccaggcagc accacaggca gagcgagttg atctcgtaca
     3901 gcgactggta catcagccag gtgcagaagc cgacgccgaa gagcatgccg gcgttgagac
     3961 cgagccagag ccagccccgg tagcgggccc cggcgaggag ccccgcgccg agggcgacga
     4021 cgacggcgta cgtgacgagg ccgagcatcg ggttggggaa gccgaagacc gccgcctgct
     4081 cgctcttcat gatgttgccg caggacacga ccgggttcag gctgcacccg ggctggaacc
     4141 ccgggtcctc gagcagcttg aacttgtcga tcgtgatcac ccagccggcc agcacgcccg
     4201 ccgccccggt gatcatcagc atccaggcga gggcccggct cccgccgatc gtccccgcgg
     4261 tctcccgcgc ggactcctcc cgctcctgcc gctgctccgg caccccgccc cgtacgttga
     4321 ccgtcgccat ggcgcgaccc cttcccgctc agccctgcag acgccggacg ggcatcagga
     4381 cgtgggcgct ctccttgagc atctcctcgt cggagacgaa cgcccgcagg cgcgcctcgt
     4441 cgaccggctg gccggggacc gcctcgggcc agggccgcac ggagcagatc aggtagacct
     4501 ggccacgctc gcgggccgcc tcctgccact cgtcgggaac cgggcactgg accttcagga
     4561 acggcaggtt gaggacggcg gagccaccct cgacgagcag cgaggcggtg atcccggcgt
     4621 ccttgtccag gtcgaagagc cggtcgccga cggagagccc catggcctcc agggcggtcc
     4681 gcatggcctg ctgacccgcc tccggcccgt cccggccgtc gccgagcgaa tacgccatga
     4741 gaaacggcgt accgggcgcg tcggcggagg gctcgctggc ccacggaatc accgtgagag
     4801 ttcccagcgg agaggcgctg cgcgccgagg aaacgacgtt ggaagtggtc atgaatcgga
     4861 tgctagtgct ccaaccaccc tttccccgcg ccgaattcac ccgatcggcc gacattcacg
     4921 ccgctggcat ttccggcgca acgaacccgg gttttcatcg ttgtgcccag agggctcccc
     4981 cgaccccgag gagatcactc atgatcgtcc cgcgccgtct cgtcctgcgg tccctcttcg
     5041 cgctggccgt caccgctttc acggggggcg ccctcgggcg cgtcacgacc cgcccgccct
     5101 ccggagcgcc cgcggagagg gcgcgcgacc cgcacgcctt cgacgagatg tacgggggcc
     5161 gtcacctcct gggcttctcc ggccccgagg gcgggccggt ggccctcgtc gacggccggc
     5221 cgctgcatct gatgcgctgc gccgacggcg gtttcgtcac cccgatcgac cactacgagt
     5281 cctgcccgac gccgctggcg gccgtccgcg cggccgtgga cgagctgggc accgcccggc
     5341 tctccccgct cgccgccgcc catggcgtcc acaccgaccc gacgggaggg agcccgcgtg
     5401 gtgtacacgc gtaagaacca gcgcgacctg accggcgccg agcgccggaa gttcgtcgcc
     5461 gccgtcctgg agctcaagcg gacgggggcg tacgaccgcc tcgtccgcac ccacatcgac
     5521 cactacacgg ccgacgggga gggccggctc cgggtcgccc acatgacgcc gagcttcctg
     5581 ccctggcacc gcaagttcct gctggagttc gagacggccc tgcgccggat cgacccgacg
     5641 gtctccgtcc cgtactggga ctggacccgc gacaacagtc cggcgtcctc gctctggggc
     5701 gaggacttcc tgggcggcaa cggccgccgg gccgacctcc aggtgatgac cggccccttc
     5761 gcgcactccg ccggacgctg gacgatcacc cagtcgatga ccgacgagcg cttcctgacc
     5821 agggacttcg gccgcccccg cgacccgatc gcgctgccga cgcaggccca gctcgacgag
     5881 gtgatgcggg agcgggtgta cgacgtgacg ccctggaact cgacgagcgc ctccggcttc
     5941 cgcaaccgcc tggagggctg ggcaccgggc cggggcaacg aacggttccg catccacaac
     6001 cgggtgcacc gctgggtcag cggcctgatg ctcggcggcg gctccgtgaa cgacccggtg
     6061 ttctggctgc accacgcgtt cgtcgacctc gtctggtcgc gctggcagca gcgcaacccg
     6121 ggggccgcct acctccccgc ggaaccgccg ccgctcgggg acgcgcagta ccgcaaggtc
     6181 gtcgcccggc acgagccgat ggcgccctgg ggagtgacac cggcgtcgat gttcgaccac
     6241 agccggatct accggtacgc ctgagggccc gggagggggc ggcccctccg gaggctcccc
     6301 gccccgcacg cacgtgtccc cccgacccgg ccggatcggg gggacacggt cgtcacgggg
     6361 gatcagccgc cgtagccgcc gtcaccgttg tcgtggccgt cggcgttgat gcaggtgttg
     6421 ccgaacgccg ggttcagcag gccgatgacg ttgacggtgt tgccgcagag gttgaccggg
     6481 acgtggaccg ggacctggac gacgttgccg gaggcgacac cgggcgagtg ggcggcgacg
     6541 gcctcggcgc ccgagtcggc gacggccagg ccggctccgc tgagggcaac ggcacccgtg
     6601 ccggcgagaa cagcggcagc cttcgcgatg cgagacatca agaactcctt ggacgtggaa
     6661 agcgaccgca ggaatcacgg ccgtcagtcc ggttcaacgt cgtaccacgg accgggtcac
     6721 ggccgttggg ccgaaaggga ggaaggaaaa ccgaaaaatg gtccgcggac cgagaaccgt
     6781 ccgccgccgg atacggcggg acggcctcgg tccacggacc gcggccatgc gacaagcctc
     6841 ttcttgcaac gaacgaaagc cctttcggtg gcggggaaga atcgtgtctt cacccacggg
     6901 gacgccgatc gcacagaaga acgaaaaggg cgcgggcgca ggggaacggc ctttcgcaca
     6961 ccgcaccgcg aaggggctcg ccgcgccgcc gcgtcagcgc gcctcgggcg ccagacccag
     7021 ctgggagtcc agcgtgccgc tcaccatcgg gggcagcatg ccgacccggg gcttcgccag
     7081 ctcgggaagg cccccgagac cgtcgccgtc gggcgcgacc accgggttgc cgacgacggc
     7141 gcccggggtg gccgccgcca tctccgagtg cggggtggcg aagagcgcgc ggccgggctc
     7201 gctgtccttc acgacctcgg gcagcggggc gtccacgacc gtcgcgggga gggtgccggt
     7261 gagcggcacg ctgggcaggg cgaggtcggg cagcgagccg atgcccttct ggaagccggt
     7321 gggcgcgccg ggcatcggga cgggtacgcc ggtggccacc gtgggggcgt ccatcgggag
     7381 caccgggtcg agcccctgga ggggcacgat caccggcgcc tcgacggccg aggccggggc
     7441 ggccagggcg gcggaggcga acgcggtcat gagaagtccc atgccggcgt gagagcgcag
     7501 agtcatgttc tgacaacgag accttcgggg gaacgactcc ggaactcccc catgtgcagc
     7561 aacggacgag gccctcaccg gtgaaggtga gggcctcggt tgacgccggg ccggtgcgcg
     7621 gcctcagtgg cgacgggcga ccctgccacc gcggaggtac acgacggtgc cgccgacgat
     7681 cagtgcggca ctgatcgcgg ccgcgcccat gagcgcggtc tcgctgcccg tttcggggag
     7741 ctcgggcggg ccggtggggg gcttggtcgt cgggtgcgtc gtgggctcct cgcagccggg
     7801 ctccggctcc tggcccggcg cgggctcctc gcactcaccg gggtgggtcg gcgggtgcgt
     7861 cgtcgggggg tgggtcggcg ggtgcgtcgt gggaggcgtg gtgggcgggt gcgtgggcgg
     7921 cttcgtcggc ggcgtcgtcg gcggcttcgt gggaggcgtc gtcggcggct tcgtcggggg
     7981 cttcgtggga ggcgtcgtcg gcggatgcgt cggaggatgc gtggtcggcg gcgtcgtcgg
     8041 cgggtgcgtg ggcggcttcg tcggaggcgt cgtcggcggc ttcgtgggag gcgtcgtcgg
     8101 cggcttcgtc ggagggtggg tcggcgggtg ggtcggcggg tgcgtgggcg ggtgcgtggg
     8161 ttcacccgga tgagtcggct cgccggggtg cgtaggttca cccggctcgt cgccgtagcc
     8221 gtcggggtcc tccgcctggt cgcagaggtc accgacggcc gcggcgacgt aaccgccgag
     8281 ttccctgctc tttccgcaga cgtccgcagg cagcggggcc tggacatgac cggcgctgcc
     8341 ggggcccgga ccgtcgcccg taccggcgtg ggtgctcgcg gccagggcga atccgccgct
     8401 cagcgacagg atgccggtcg ctgccgccgc ggtgagtact ttcctgctga tgatggaccg
     8461 cataccgctc ttcctctgga gaaagggaga gaccggcgag gatcccccct cgctccgacc
     8521 ggcctgatcc acgccgacgt tcgcgcggga ctggccagag ggtatgggtc ggcgaacccc
     8581 gtgcaacggg ggccacacgg cagctgatca gaaaatcatt cgatcagccg accgtgggag
     8641 gaggcggcgt cgaggccgcc gcaagtgccc gtggaggcag gcttgctgag gtggtgtcag
     8701 cctggcgtgg agccggtgtc agccaccgag cggcaggccg ccgccgaccg ggaggccacc
     8761 cagcagcgag ccgcccttcg tggtctcgtt cagctgggtc gcggtgtccg tgacggtctt
     8821 gaccggggag ccgtccgtgg tgctgctcag gacgtccgac ttcagcccat tggcggcgat
     8881 cgcttcgagg ccaccgttca ggctggtggg ggtcagcgcc tccgtggcca tggcgggggc
     8941 ggcagcgccg agggccatca gcgaaccggc gacaaccgcg gcgaccttgg tgggcttcat
     9001 ggggtgaatc cttcctctaa gtcttcaagt cacttaccgc acaggcctct tggccgaatc
     9061 ccgtgcgctt tgttctgctt ctgtaacgaa cggcgtgccg cacggaaact caagaaggaa
     9121 ggatttctcg acactgcacc cgatcgatgc ggcgcggtgc tatttgccga tcgggcaccg
     9181 ccgcggccgg gccgcgccgc cgccgcacgc gcctgtgccg gcccggcggg acgccggacc
     9241 ggcacgaggg cctgcggggg gctaccggac cggcagcgcg ggcgcggccg gcagctcggg
     9301 tacggcggcc ggcggggcgg ccggcagctc cggcggagcg gcgggcagct cgggcgtggt
     9361 gaccgggagc gcgggcagcg cgggcagtcc ggccaggtcg ggagcgggca ggccactgcc
     9421 gaggaccgtg gagacggcca ggttgaccag cgaggtcagg gtcgccgtga cctgcgggac
     9481 gactccgccg gcgtcgccgg aggtgaccgc ggcgagcagg gcggcgaccg ccttctcgac
     9541 cgtggcgagg gcgtcgtcga cgacgtccgc cggggcggcc gccttcccgg cccaggccgc
     9601 gttcgcgtcg gccgcgacgg gcagggtcac gggcggcgtg acggggagtt cggccgcggg
     9661 cggcgtgacc gggagatcgg tcgagggggg cgtgaccggg agatcggtcg acgggggcgt
     9721 gaccgggagg ccggtcgacg gcggtgtgac gggtgcgtcc ggcagcgggg ccggcgcggt
     9781 ggccttggcc tcctcgacgg ctgccgcgat ctcggccttg agggcctcgg catcgaccgc
     9841 cgggagctga ccggagtcgg ccttgagcgc ggcggtgacg agttcggtca cgggagtggt
     9901 caccgagccg agctctccga gcgcctcggc ctgggccagc agggcggcga catcggggag
     9961 gggtgcgcgg gcggcccgtt cggccgcggt agtcggatgg tgttcgccgg cgatggcggg
    10021 tcccgccgtg ccgagggtga tgacggcgga tatcgccagg gcggtgatgc ggcgcgtggc
    10081 caggggacgc atatgtgttc cttttcctta tgcgtcggac aacttccctc tcaccgtgcc
    10141 tgcgggtata gcgctccgca accgcagaac tactgagcgc cacgcctccg ttcgagtgaa
    10201 tccacgcctc gaacatgccc ccggaagggg cgtacgccgt tgcaccgacc ggcgcacgac
    10261 ggtgccgccg aacgagtacc gaccccatga ccgcaaggag aaagccggtg cgcccactcc
    10321 gtcgggagtg ggcgcaccgg cttcggaagg actgatcagg cgtgccggat caggcgttga
    10381 cgcaggtgtt gccgaaggcc gggttcagcg cgcc
//
