LOCUS       NZ_LIVV01000002        22745 bp    DNA     linear   CON 28-MAR-2024
DEFINITION  Streptomyces sp. CB02009 scaffold2, whole genome shotgun sequence.
ACCESSION   NZ_LIVV01000002
VERSION     NZ_LIVV01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CB02009
  ORGANISM  Streptomyces sp. CB02009
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 1350328)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1350328)
  AUTHORS   Yan,X., Ge,H., Hindra,F., Yang,D., Huang,T., Crnovcic,I. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-AUG-2015) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC Genomics Workbench v. 7.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905825.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:41:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,214
            CDSs (total)                      :: 8,139
            Genes (coding)                    :: 7,984
            CDSs (with protein)               :: 7,984
            Genes (RNA)                       :: 75
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 51 of 155
            Pseudo Genes (incomplete)         :: 117 of 155
            Pseudo Genes (internal stop)      :: 15 of 155
            Pseudo Genes (multiple problems)  :: 26 of 155
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:06:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1316011
            Orig. end                         :: 1338756
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LIVV01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22745
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iv"
                     /region_number="11"
                     /rules="(cds(LANC_like and Pkinase) and not micKC)"
                     /tool="antismash"
     cand_cluster    1..22745
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /kind="single"
                     /product="lanthipeptide-class-iv"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22745
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12745](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12745)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
     gene            complement(381..986)
                     /locus_tag="AMK27_RS12930"
                     /old_locus_tag="AMK27_12720"
     CDS             complement(381..986)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005307464.1"
                     /locus_tag="AMK27_RS12930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_12720"
                     /product="hypothetical protein"
                     /protein_id="WP_073905735.1"
                     /transl_table=11
                     /translation="MNDDDYSATELGSHWFERPTPEATPDRVEGEVLRFGPGVTAAALR
                     RAENSPTVVEIWHGTLPGVPAPRPARSRRPWRYAFAAVVLVAVLVFLAWRQYGPGVAVR
                     DVAVSAPGARLGCDGTADVVGLVRTDGRPGTLTYRWERSDGTRSGVLTEKLARGQKEAR
                     LHLLWTFHGPGTHRAVARLVITSPGTHSSEATFTYDCD"
     gene            complement(983..2671)
                     /locus_tag="AMK27_RS12935"
                     /old_locus_tag="AMK27_12725"
     CDS             complement(983..2671)
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017948949.1"
                     /locus_tag="AMK27_RS12935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_12725"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_073905738.1"
                     /sec_met_domain="Pkinase (E-value: 5.7e-43, bitscore:
                     143.2, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGAWVVPGYTEARELGAGASGRVVLATHEETGLPVAVKYLSERFR
                     SDEPFVRGFRSEARLLGALDSPYVVGLYEYVEAPRGAAIVMELVDGVALRALIAREGST
                     GPEAALVVLKGSLLGLAAAHRAGVVHRDYKPENVLVAADGSSKLVDFGIAAGRGATPGV
                     AGTPAYMAPEQWNGAPASPAADVYAATATFFECLTGRKPFTGDNFAELALHHIDSPVPD
                     GQAPEPLRPLIRRGMAKSPHERPENAAAFVTELEAVAAAAYGPDWEERGRGRLAALAAL
                     LPLLLPSSGGGVSEGTTVFATTTLPTPPPRPRWRLPRGVPAGAAALVLALLLALAARAG
                     VEGTNGDKAAEAFATTSTGPGTSGPGPDTSPPSPSLSPSDSDSPEPSPSASTTEPSASG
                     SVEPSATSDGPPTEDTTTAPPSTSPPTPTPTSTSPTAPTPTTPTATPTTTTPPPPPVVV
                     TAVSVTSLRQTGPTTASGTVEVTTDGTGPVTIRVEWFTGDEKGAPGAPDGAESYQREGA
                     TQYTLTLAHDVRGAGCYWGLRATTDPAASNGGSLQQIFIRRCVIS"
     gene            3150..4787
                     /locus_tag="AMK27_RS12940"
                     /old_locus_tag="AMK27_12730"
     CDS             3150..4787
                     /NRPS_PKS="Domain: Abhydrolase_1 (128-289). E-value:
                     1.4e-14. Score: 46.3. Matches aSDomain:
                     nrpspksdomains_AMK27_RS12940_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020132080.1"
                     /locus_tag="AMK27_RS12940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_12730"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_241847448.1"
                     /sec_met_domain="PF00561 (E-value: 1.2e-16, bitscore: 57.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEQHIGPDGLPSVRGTVRTGRRRTARHIPPAGSPHRTRTRTALV
                     AAALVVIGALGPTPGSALSPPAEGPRPGPPARFVPGPCPETPEPIPGRCGFLEVPENRT
                     RKKTRTIRTTVAIIPAASARPAADPVVFMEGGPGGDAIGAIPFLVASQVNRDRDLIVMT
                     QRGALHSQPNLACPEIDRFNATAVGLPYDAPSTGRGLVRAAKECRDRLTADGADLASYN
                     TTENAADFADLRTALGIRKWNVYGYSYGTDLGLTYLRRHPQGIRTLAIDSVVPPQTVSL
                     PWAWDSAQEGINAIFAACEAQPACASRYPELSRTLTQQVRRLEANPLTLTVPPPGGGTP
                     VKVVLDGGTLVNLLVADGRLVPSADVPAALYELAAGNPERLARAQAAGATPAVGEFAHG
                     LTHSVACAEWAPGYSKRDVLKAGRRAFPGFPDSVLAHAPQLPFEHDLCRAWNVPDRTAV
                     QRIATHSEVPALIITGTFDAKTGAGWGPFAGRTLPRSTAVVVPGITHWVVPQEPCAASV
                     LVSFLARPTAPDTGCVAGVVPKPFTIIP"
     aSDomain        3534..4016
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMK27_RS12940_Abhydrolase_1.1"
                     /evalue="1.40E-14"
                     /label="AMK27_RS12940_Abhydrolase_1.1"
                     /locus_tag="AMK27_RS12940"
                     /protein_end="289"
                     /protein_start="128"
                     /score="46.3"
                     /tool="antismash"
                     /translation="PVVFMEGGPGGDAIGAIPFLVASQVNRDRDLIVMTQRGALHSQPN
                     LACPEIDRFNATAVGLPYDAPSTGRGLVRAAKECRDRLTADGADLASYNTTENAADFAD
                     LRTALGIRKWNVYGYSYGTDLGLTYLRRHPQGIRTLAIDSVVPPQTVSLPWAWDSAQ"
     gene            4810..6504
                     /locus_tag="AMK27_RS12945"
                     /old_locus_tag="AMK27_12735"
     CDS             4810..6504
                     /NRPS_PKS="Domain: Abhydrolase_1 (147-315). E-value:
                     5.6e-12. Score: 37.7. Matches aSDomain:
                     nrpspksdomains_AMK27_RS12945_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020132081.1"
                     /locus_tag="AMK27_RS12945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_12735"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_073905740.1"
                     /sec_met_domain="PF00561 (E-value: 5.3e-15, bitscore: 51.8,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPRTTPRRRPVRLPATLAGATAGALVAGLVAMPAHAESATDGPH
                     RPIGTVARTVGDARFVPGPCPRTADPIPDLARARCGTLTVPENRSKPKGADKPKGAEGA
                     DEHKAPDKPKASDKPRESGAHRGRTITLAVAIMPAESRTPAPDPIVWFAGGPGDDAVSE
                     IPMALAGGLNRDRDVIFMSQRGTYSADPVLTCPNIDEFNARALGLVSNAPATGRLHVEA
                     TRACRDRVDGLGADRSTYDDIESSADYEALRRTLGVRKWNVFGISYGTHLALNYMRLHP
                     KGIRSVGIDGVLPPSLAGGAVTWKAAREGFDGLFKACAEQPACNTRYPNLKATFLRLVS
                     ELEAEPITTTVTVPTQPEPVKVVLDGSNLVGWLTSATHVAAGVPRSLDELAHGNPQRIA
                     EQLAGGKYSPQAIGRVAHGLVYGVFCRQWTPYESRADIIRGGRRAFPSFPGSMLANAPQ
                     LAWLHDDCRAWDVPPAPAWIRDVTRSDIPTLALSGGFDAQTAPSNGAYVARTLSRSHAV
                     TVPYVAHVVFADSPCAQTITTSFFADPAAPDTRCLAGLQPPQFEIAP"
     aSDomain        5251..5754
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMK27_RS12945_Abhydrolase_1.1"
                     /evalue="5.60E-12"
                     /label="AMK27_RS12945_Abhydrolase_1.1"
                     /locus_tag="AMK27_RS12945"
                     /protein_end="315"
                     /protein_start="147"
                     /score="37.7"
                     /tool="antismash"
                     /translation="PIVWFAGGPGDDAVSEIPMALAGGLNRDRDVIFMSQRGTYSADPV
                     LTCPNIDEFNARALGLVSNAPATGRLHVEATRACRDRVDGLGADRSTYDDIESSADYEA
                     LRRTLGVRKWNVFGISYGTHLALNYMRLHPKGIRSVGIDGVLPPSLAGGAVTWKAAREG
                     FDGLF"
     gene            6683..7537
                     /locus_tag="AMK27_RS12950"
                     /old_locus_tag="AMK27_12740"
     CDS             6683..7537
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019891068.1"
                     /locus_tag="AMK27_RS12950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_12740"
                     /product="DMT family transporter"
                     /protein_id="WP_073905742.1"
                     /transl_table=11
                     /translation="MGVVLPVLFSLFAAFSNALATVLQRRAALTVPQSDSFRPGLILDL
                     LHRPLWLAGILAVIAAGVGQAAALATGPLALVQPLFVLELPLALLIATLLTRERLPARL
                     WAAVAGVVLGLGVALAAASPTGNRTHVALDRWVPVLVACAVAVVALAAVGLRRPPGRAR
                     AGCLGAATAICYALTAALMKTSMHILGDGGIGAFLTAWQTYAFCAAGIAALLLLEHAMQ
                     GGPLVASQPALTLGDATVSLSLGVLLYEEHVRAGWWLLPQLAGIALIVLGVFALARSGV
                     GTS"
     gene            complement(7599..8516)
                     /locus_tag="AMK27_RS12955"
                     /old_locus_tag="AMK27_12745"
     CDS             complement(7599..8516)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015031829.1"
                     /locus_tag="AMK27_RS12955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_12745"
                     /product="ABC transporter permease"
                     /protein_id="WP_079188375.1"
                     /transl_table=11
                     /translation="MTDLTVKSPETPPTPDDPGAPGTSGALGNAETHGSGWPARLRHEL
                     RAIHALVYRDLLRLAGQRTHTALMLLHPMLYLLILGGGLAALIPRSSLGVGYQTYLFPG
                     MLMMTVQTPAIMVGIRLITDRQSGYLRELLMAPVSRATLLLGHCVGGTVTAAAQGAVLL
                     CLAGTVGLPYDPLLLGLLLGGMILASFTITALALALAVTLRRPETFHTLLGLIMMPLLF
                     LSGGFFPLHTLPGWAQTLAAANPLAYAVDLLRRCITHLVPDQQAVTGIAWAGRQPPLPL
                     EAGLLLATGLLALLWAARRFNRPE"
     gene            complement(8513..9532)
                     /locus_tag="AMK27_RS12960"
                     /old_locus_tag="AMK27_12750"
     CDS             complement(8513..9532)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018552846.1"
                     /locus_tag="AMK27_RS12960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_12750"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_241847475.1"
                     /transl_table=11
                     /translation="MRGLVKSYPGPQGTTTHAVRGLDLDVAQGETFAFLGPNGAGKSTT
                     IAVLCALARPTSGHATVAGADVVERPHEVRRRVGMLFQHSALDADLTAEQNLHIHARLY
                     GLARRHARSRAAEVLETAGLTDRRRSPVRTLSGGMRRRLEIARALLHSPRVLFLDEPTT
                     GLDPHARAQVWEHLRALRDRHGSTLFVTTHYLEEAENCDRLAIVDQGRVVAQGTPLALK
                     AAIGDDLVVLRTGDDTEARRVVRGIVPPDRTVAADGDGVSLRLPDGSTWIPRLCAALQR
                     HGIAVHAASAAPPTLDDVFFHHTGRSLDAAKPGHAKAMAGAPAATTAGVGASETGGSR"
     gene            complement(9801..9956)
                     /locus_tag="AMK27_RS42995"
     CDS             complement(9801..9956)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015031827.1"
                     /locus_tag="AMK27_RS42995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="VenA family class IV lanthipeptide"
                     /protein_id="WP_198955847.1"
                     /transl_table=11
                     /translation="MENQDIELLAHLHALPETDPVGVDGAPFAATCECVGLLTLLNTVC
                     IGISCA"
     gene            complement(10001..12745)
                     /gene="lanL"
                     /locus_tag="AMK27_RS12965"
                     /old_locus_tag="AMK27_12755"
     CDS             complement(10001..12745)
                     /codon_start=1
                     /gene="lanL"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: Pkinase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003955211.1"
                     /locus_tag="AMK27_RS12965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_12755"
                     /product="class IV lanthionine synthetase LanL"
                     /protein_id="WP_073905746.1"
                     /sec_met_domain="Pkinase (E-value: 6.7e-18, bitscore: 61.0,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.2e-49, bitscore:
                     164.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSQATEVELEGLLRKALHATGTGARWAADSDEMWCRVTPGTGTR
                     REQGWKLHVSATAASAPAVLEKALDVLLREESAFKFARSLDQVSALNSRATPRGSSGKF
                     ITVYPRSDAEAALLAQALHGATAGLAGPRILSDQPYAVHSLVHYRYGSFVGRRRLSDDG
                     LLVWFIEDPDGNPVEDKRTGQYSPPSWAVSPFPATVPVAPRSAEGSSGSEGTAGKDGAA
                     SVRTPVLLGGRFSVREAIRHTNKGGVYRGTDTGTGAPVVIKEARPHVEADASGCDVRDW
                     LRAEARILEKLKGTGLAPEPLALFEHAGHLFLAQEEVPGITLRNWVAEHFRDAGAERYR
                     AEAPAQVERLVDLVAAAHAQGCVLRDFTPGNVMVRPDGELRLIDLELAVLDDEAALPTR
                     VGTPGFSAPERLDDAPVSPTGDYYSLGATACFVLAGKVPNLLPDEPATRTAEQRLAAWL
                     TACAEPLRLSDGLAEMILGLMKDDPAERWDPARAREALGKAEPRRRLSDAVRHADRPEG
                     GLGDVPQDTAGTVDHAVAGMVEHLVASMTPADPHRLWPVSTLAGESDPCTVQQGAAGVL
                     AVLTRYWELTGDERLPELISTAGRWIADRADIRSPRPGLHFGGRGTAWALYDAGRAVDD
                     RGLMEHASALALAPQQVTPHHDITHGSAGSGLAAVHLWQRTGDPRFAELAVDAADRLVA
                     AARRDPSGVSWPVPAEAASSEGGKRYLGFAHGSSGIGCFLLAAASVSGRPEHKDLAVEV
                     GEQLVADAVLTGEAAQWPAQAGDLPTAPYWCHGAAGIGTFLVRLWQATGDDRYADLARR
                     STYAVTERASRAALAQCHGLAGNGDFLLDMADATGDPVHRTMAEDLARLIVSERAQRRA
                     QVVFPNEYGDVSTSWSDGSAGILAFLLRIRHTDPRHWMVQLPV"
     misc_feature    complement(12928..12940)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 22.13"
                     /tool="antismash"
     gene            complement(13019..13813)
                     /locus_tag="AMK27_RS12970"
                     /old_locus_tag="AMK27_12760"
     CDS             complement(13019..13813)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (8-120). E-value: 6.8e-07. Score:
                     21.3. Matches aSDomain:
                     nrpspksdomains_AMK27_RS12970_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004979307.1"
                     /locus_tag="AMK27_RS12970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_12760"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_073906118.1"
                     /transl_table=11
                     /translation="MLVDLTRRTALVTGSTQGIGAAIAAGLARAGARVGVNGRTEERVA
                     QAVAALRAEVPDADLVPVVADVTTERGARLAAEALPHVDILVNNLGVFGEADPLEISDD
                     EWRRYFEVNVLAAVRLIRQYLPGMSERGWGRIQNIASDSAVVIPAEMIHYGMSKTALLA
                     VSRGFAKQAAGTGVTVNSVIAGPTHTGGVEQFVYELVDRSLPWDEAQRVFMREYRPQSL
                     LQRLIEPEEIAHMVVYLASEQASATTGGALRVDGGYVDSILP"
     aSDomain        complement(13454..13789)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMK27_RS12970_PKS_KR.1"
                     /evalue="6.80E-07"
                     /label="AMK27_RS12970_PKS_KR.1"
                     /locus_tag="AMK27_RS12970"
                     /protein_end="120"
                     /protein_start="8"
                     /score="21.3"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="TALVTGSTQGIGAAIAAGLARAGARVGVNGRTEERVAQAVAALRA
                     EVPDADLVPVVADVTTERGARLAAEALPHVDILVNNLGVFGEADPLEISDDEWRRYFEV
                     NVLAAVRL"
     CDS_motif       complement(13715..13783)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMK27_RS12970_0001"
                     /evalue="3.10E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="AMK27_RS12970"
                     /protein_end="33"
                     /protein_start="10"
                     /score="13.4"
                     /tool="antismash"
                     /translation="LVTGSTQGIGAAIAAGLARAGAR"
     misc_feature    13792..13812
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.35"
                     /tool="antismash"
     gene            complement(14044..15447)
                     /locus_tag="AMK27_RS12975"
                     /old_locus_tag="AMK27_12765"
     CDS             complement(14044..15447)
                     /GO_function="GO:0008484 - sulfuric ester hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015031825.1"
                     /locus_tag="AMK27_RS12975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_12765"
                     /product="sulfatase-like hydrolase/transferase"
                     /protein_id="WP_073905748.1"
                     /transl_table=11
                     /translation="MSTPLSRRALGGVAAGAAAAAALGAGASAAHAAPAGEPRERPFRA
                     AHPRRHSRRPNILFILGDDLGWADLSSYGSPHIRTPHLDRLAREGVRFTDAYSGSATCS
                     PTRFSLYTGRYPGRTKGGLAEPIADKSVGLEPTHPTLASLLRDSGYSTALIGKWHCGYL
                     PDYSPTRSGWDEFFGNFGGALEYYSKLGLGGEYDLYEGDAEYKDLRYYTRILTERAGEY
                     VSRDHDRPWLLNLNFTTPHWPWIADGDKEASDEIVRRIKAGDRSALWHQDGGSVEKYKE
                     MVEDLDRSIGQVLKALKRSGQEQDTLVFFASDNGGERFSYNWPLAGNKGSLQEGGIRVP
                     SILRWPARIDGGQVSDLPVFTPDWTATLLELAGARPHPAYPLDGTSLAGHLLRGADVPE
                     RDLFWRVRGERALRRGDWKYYRGKSGRDQLFDLSEDSREQADRAPLEPARLAELRAAWE
                     RTDAGLLRY"
     misc_feature    complement(15612..15627)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.94"
                     /tool="antismash"
     gene            complement(15870..17315)
                     /locus_tag="AMK27_RS12980"
                     /old_locus_tag="AMK27_12770"
     CDS             complement(15870..17315)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015031823.1"
                     /locus_tag="AMK27_RS12980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_12770"
                     /product="cytosine permease"
                     /protein_id="WP_073905750.1"
                     /transl_table=11
                     /translation="MPVQHTPGERLSVETRTIEVIPDAERHGTPRSQFTLWFGANMQIT
                     AIVDGALAVVFGADALWAIPALLIGNVLGGIVMALHSAQGPRLGVPQMISSRAQFGVYG
                     AVLPLLLVILMYLGFAATGSVLAGQALSEMLHIGNTNAGILVFGALTAVVAVTGYRLIH
                     IAGRVATVVGVLGLGYLLVRLFTQYDVGAHVGTKGFETATFLLAVGLGAGWQLTFGPYV
                     ADYSRYLPRDTSTRATFWSTFAGSVIGSQWAMTLGGLTAAVAGKTFLSDQVGFLGDLAG
                     PAVLAVLVYLVIVVGKLTVNCLNAYGGFMSILTTVTAFDGRSRISAGARAAYIVGFTAV
                     SMVIALAASDDFLDNFKNFVLLILMVFTPWSAINLVDYYLVSRERVDIPALYDPAGRYG
                     RWNVTALTCYAVGVAVQIPFLATKLYTGAITKRLDGADISWIVGLVVTAALYWLWVRRT
                     ADPPAETIHPAVTEADDTAAPVG"
     misc_feature    complement(17421..17435)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.89"
                     /tool="antismash"
     misc_feature    complement(17492..17506)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.26"
                     /tool="antismash"
     misc_feature    17511..17520
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.21"
                     /tool="antismash"
     gene            17562..18266
                     /locus_tag="AMK27_RS12985"
                     /old_locus_tag="AMK27_12775"
     CDS             17562..18266
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009192040.1"
                     /locus_tag="AMK27_RS12985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_12775"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_073906119.1"
                     /transl_table=11
                     /translation="MVGSVTENTENTAAGSPASHALTPLVDAYVGDPAVRAEWDDRYLD
                     RQQLWSGRPNGALVAEVAGLTPGRVLDVGCGEGADAVWLARRGWDVTALEVSGVALERA
                     AGHARDAGVAVRWVHAALTDAALPPASFDLVSAQYPALLRTPDAAAERALAGAVAVGGV
                     LLLVHHAGMDTRPADESGFDPADYVWPSMVTAVLGDDWVVEVDEQRARVAPDGGAGAHH
                     TDDLVLRARRLR"
     misc_feature    complement(18341..18354)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: medium, score: 18.16"
                     /tool="antismash"
     gene            18344..18970
                     /locus_tag="AMK27_RS12990"
                     /old_locus_tag="AMK27_12780"
     CDS             18344..18970
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010981484.1"
                     /locus_tag="AMK27_RS12990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_12780"
                     /product="hypothetical protein"
                     /protein_id="WP_073905753.1"
                     /transl_table=11
                     /translation="MALRPDEFYDHALAAADAEHRLPLARMTGWSISPFEAEGLRVSPL
                     RPPVLPEPPRHGEDPSDCASCRDRGDGIWFNDRWRLTRIEGVGVPLVLMLHPLEHHDMA
                     DLPDELAAELGVLSTHIVRHVQALPHVSRAHVYRIGDGGAHLHIWFFARPEGQTQLYGS
                     WMPVWDDLLPEYPADVADADAAAVADALVASAGGSRTPADASTPA"
     gene            complement(19045..19515)
                     /locus_tag="AMK27_RS12995"
                     /old_locus_tag="AMK27_12785"
     CDS             complement(19045..19515)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015928.4"
                     /locus_tag="AMK27_RS12995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_12785"
                     /product="peptidase inhibitor family I36 protein"
                     /protein_id="WP_073905755.1"
                     /transl_table=11
                     /translation="MRISRALATALTAGALALLTAPVADARGAVPEAALPGAATAPAAV
                     VPAAAPGPDGFLYAWEHPHAGGFHCRWNSANANWAGCRDKVSDVWNNGYPGVAEDVKLY
                     RDTDWNGSWVCLHQGHSLPDLGASGLRFFSPGHGQGELVNDRVGSHLWVSAC"
     gene            complement(19708..20643)
                     /locus_tag="AMK27_RS41795"
                     /old_locus_tag="AMK27_12790"
     CDS             complement(19708..20643)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK27_RS41795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AMK27_12790"
                     /product="hypothetical protein"
                     /protein_id="WP_073905758.1"
                     /transl_table=11
                     /translation="MPRNSHARRPLLAVAAAVACTTIALSVTALPGPGRPSAGERPPPP
                     RLIATTVATADDRLLHDAEQRLLRDCMGRHGFTYRVFPLGDETESTLFPYVVDDAGWAL
                     RHGYGAELRRQRAALAKSDPNRAYFATLPTDRKAAALVTANGPSPDGLTVRLPGGGTMR
                     RSDRGCVAEAQHQLYGDLGAWFRSSIRVGTLRQILRSRVVADSGYQKSLGVWRRCMGRV
                     GYAFATPAAARAAALSPVRPFPEDHEIRLALAEVRCAAESGLSRTARRLDAHHDRLLAE
                     EYRADIETRDRLTAAALPRARRILGDPPQA"
     gene            21153..22688
                     /locus_tag="AMK27_RS13005"
                     /old_locus_tag="AMK27_12795"
     CDS             21153..22688
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016430516.1"
                     /locus_tag="AMK27_RS13005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_12795"
                     /product="family 43 glycosylhydrolase"
                     /protein_id="WP_241847449.1"
                     /transl_table=11
                     /translation="MHDRTTSGGGPFRRAGAGRRGRLAAVGRGRTALRRRGFATAMAAL
                     GAAACLAAFPAGATTPDPIRAPAAVPDSVRGRTTEEPRFLPAGAAAASPTAPVLDREFA
                     DPDVVEVDGVFHAYATNVAGRHVQHATSTDLVHWTVDEKDVLPVPGDWVKPDPPRDVWA
                     PEVFDNGDGFTLQYTARDRVGGRQCIGAALASSPDGPFRPAGDAALVCPTEAGGAIDAS
                     SYTENGTRHLLWKSDGNCCGLDTWLHIQPVSWDGTRVTGEPVRLLRQDRAWEGGLVEAP
                     TLVKRDGRYVLLYSAGDYRTTGYATGWAIADALTGPYVKGDEPLLTTDSFSGTIGGPGG
                     QDVVTGPGGRDRILFHGRGADPSRRALYVADLGFADGRPVVRGSKTLHQAELARVHRAT
                     IREAKDAWGGRAVGHIDEPDSFVEFRVYAASSGPHTLTVRYGNGSLDAAGAPAAATHGL
                     TVNGAAVGVVEYPYTGWDAWQPREVPVELREGWNTLRLSKGERYTELDAVQVA"
ORIGIN
        1 ggcccggcag gtgacgattc cactgctgtt cctgctgcag tgggacgacg agggaaaccc
       61 ccggcaacgg gccctggacc tcttcgacgc cttcggcagc aaggagaaga cgctgcacgc
      121 caacctcgga gggcacaccg gtaccccggg gttcgagctg gaggacgggt gccggttcct
      181 ggaccggcac ctgaagtgac gccgggccgc acggcgggca gccgacggta gtcgccgccc
      241 accggaccgc cgccgtcgag gacgggcccc ggccctcctc gacggcggca cgctccgtcc
      301 cctgtacctc ctgcgcacca cgcggagggc tcaggcggga tcgggaggta cgggacacgt
      361 gccgctcgtc ggccggccca tcagtcgcag tcgtacgtga acgtcgcctc cgaggagtgg
      421 gtaccagggg aggtgatcac gagccgtgcc accgcccggt gggttccggg cccgtggaag
      481 gtccacagga gatggagacg cgcctccttc tgcccgcggg ccagcttctc ggtcaggaca
      541 ccggaccggg tgccgtcgct gcgttcccag cggtacgtga gggtgccggg acgcccgtcc
      601 gtgcggacca ggcccaccac gtccgccgtt ccgtcgcagc cgagccgggc acccggtgcg
      661 ctgaccgcga catcccgcac ggcgacgccg ggaccgtact gccgccaggc gaggaagacc
      721 aggacggcga ccaggacgac ggcggcgaac gcgtaccgcc acggccgtcg ggagcgggcg
      781 ggccgtggcg cggggacacc ggggagcgtg ccgtgccaga tctcgaccac cgtgggactg
      841 ttctcggccc gccgcagggc cgcggcggtc acgcccggcc cgaaccgcag cacctcgccc
      901 tccacccggt cgggtgtcgc ttccggcgtc ggacgctcga accagtggct gccgagctcg
      961 gtggcgctgt agtcgtcgtc gttcatgaga tcacgcaccg ccggatgaag atctgctgca
     1021 gggaaccgcc gttcgaggcg gcgggatccg tggtcgcgcg caggccccag tagcagccgg
     1081 cgccccggac gtcatgggcg agcgtgagcg tgtactgagt ggctccctcg cgctggtagg
     1141 actcggcgcc gtcgggtgcg cccggtgctc ccttctcgtc cccggtgaac cactcgacgc
     1201 ggatcgtcac cggccctgtc ccgtccgtcg tgacctcgac ggtgcccgag gccgtggtcg
     1261 gccccgtctg gcgcaggctc gtgacggaga ccgccgtcac cacgacggga ggaggcggcg
     1321 gagtcgtggt cgtgggtgtc gcggtcggag tcgtgggcgt gggcgcggtg ggcgatgtcg
     1381 aggtgggcgt gggcgtcggc ggagacgtcg agggcggcgc cgtcgtcgtg tcctcggtgg
     1441 gcggcccgtc ggaggtggcg ctcggttcga cgctgccgga cgcggagggc tccgtcgtcg
     1501 acgccgacgg agacggttcc ggactgtccg agtccgaagg cgacagcgaa ggcgacggcg
     1561 gtgacgtgtc ggggccgggc ccggacgtgc ccggcccggt gctcgtcgtc gcgaaggcct
     1621 cggcggcctt gtcaccgttc gtcccctcga caccggcccg cgcggcgaga gcgagcagca
     1681 gcgccaggac gagcgcggcc gcacccgccg gtactccgcg ggggagacgc catcgggggc
     1741 gcggcggcgg cgtcggcagc gtggtggtgg cgaacacggt cgtgccctcc gacacaccgc
     1801 cgcccgagga ggggaggagc agcggcagca gagccgccaa cgccgccagc cgtcccctgc
     1861 cgcgctcttc ccagtccggc ccgtaggccg ccgcggccac cgcttccagc tcggtcacga
     1921 acgccgccgc gttctccggc cgctcgtgcg gggacttggc catgccccgg cggatcaacg
     1981 ggcgcagcgg ctcaggggcc tgaccgtcgg gcacgggcga gtcgatgtgg tgcagggcga
     2041 gctcggcgaa gttgtcgccg gtgaacggct tgcggccggt cagacactcg aagaaggtcg
     2101 cggtcgcggc gtagacgtcc gccgccggtg aggcgggagc gccgttccac tgctcgggcg
     2161 ccatgtaggc gggcgttccg gcgacacccg gtgtggcgcc ccggccggcc gcgatcccga
     2221 agtcgaccag cttggacgac ccgtcggcgg cgaccagcac gttctcgggc ttgtagtcgc
     2281 ggtgcacgac gcccgcgcgg tgggcggcgg cgagccccag gagggagccc ttgagcacga
     2341 cgagagcggc ctcggggccc gtcgacccct cgcgcgcgat gagcgcacgc aacgcgacgc
     2401 cgtcgacgag ctccatcacg atggccgcgc cccgcggcgc ctcgacgtac tcgtacagtc
     2461 ccacgacgta cggactgtcc agtgccccga gcagccgggc ctcggaccgg aacccccgca
     2521 cgaacggctc gtccgaacgg aaccgctcac tcaggtactt cacggcgacc ggcagcccgg
     2581 tctcctcgtg cgtggcgagc accacccgcc cgctggctcc ggcacccagc tcccgggctt
     2641 cggtgtaccc cggcaccacc catgcgccca tgcccgtccc cctgacgctt tggccgactt
     2701 tccccctcac agggacagat tctcgccacg gccggttccc cggggaaggg ggcgaagggg
     2761 ctcgttcccg aacccggccc gcgggagggg cccatgggaa gccggaggcc cgggggagcg
     2821 ggccggaccg cctcggccgt gatcgactga cacggcggcg gaacgggacg acctgcgggc
     2881 cctgccccct tgctggacgc cgtagaggcg gccatcgacg cggcgaccgg tgaaggcgcc
     2941 cccagccact tccgagccct ccgccccacc ctcgtctcgt gatccccctg cgtacggcga
     3001 acgtctgctc cgagtggact ccttgagtgg tgcgcctccc gcggcggacg caagctggcg
     3061 tgcgccgacc ccgccggacc acgcggcggg cggccacgcc cacgcgcccc ggcccagagc
     3121 gccggggaat gcccgagaaa tgggatcaca tggcggaaca gcacatcggt ccggacggcc
     3181 tgccctcggt tcgagggacc gtcaggaccg gacggcgccg aacggcgcgg cacatccccc
     3241 cggcggggag cccccaccgc acgcggacca ggacggcgct cgtcgcggcc gccctggtcg
     3301 tgatcggcgc cctcggcccc acccccggca gcgccctgtc gccccctgcc gaggggccac
     3361 gaccaggacc cccggcacgc ttcgtgcccg gtccgtgccc cgagacgccg gagccgatcc
     3421 ccgggcgctg cgggttcctg gaagtgccgg agaaccgcac gcgcaagaag acccgcacca
     3481 tccggacgac cgtcgcgatc atcccggccg cctcggcgag gcccgccgcg gacccggtgg
     3541 tgttcatgga aggcggtccc ggtggcgacg cgatcggcgc catccccttc ctggtcgcct
     3601 cccaggtgaa ccgggaccgc gatctgatcg tcatgaccca gcgcggcgct ctccactcgc
     3661 agccgaacct cgcctgcccg gagatcgacc ggttcaacgc caccgccgtc gggctgccct
     3721 acgacgcccc gtccaccggg cgcgggctgg tccgcgcggc caaggagtgc cgcgaccgcc
     3781 tgaccgccga cggcgccgac ctcgcgtcct acaacaccac cgagaacgcc gcggacttcg
     3841 ccgacctccg caccgccctc ggcatcagga agtggaacgt ctacggctac tcgtacggca
     3901 ccgacctggg cctcacctac ctgcgcagac acccccaggg catccgcacc ctggcgatcg
     3961 actcggtcgt gccgccccag accgtgagcc tgccctgggc ctgggacagc gcccaggagg
     4021 gcatcaacgc gatcttcgcg gcctgcgagg cccagcccgc ctgcgcgtcc cgctacccgg
     4081 agctctcccg cacgctcacg cagcaggtcc ggcgcctgga ggcgaacccc ctcacgctca
     4141 ccgtgccgcc gcccggcggc ggaaccccgg tgaaggtcgt cctcgacggg ggcaccctgg
     4201 tgaacctgct ggtcgccgac ggccgcctgg tcccgtccgc cgacgtccct gccgcgctgt
     4261 acgagctcgc cgccggcaac ccggaacgcc tcgcgcgggc ccaggccgcc ggcgcgacgc
     4321 ccgccgtcgg cgagttcgcc cacggtctga cgcactcggt ggcctgcgcc gagtgggcgc
     4381 ccggctattc gaagcgcgac gtgctgaagg ccggccgccg agccttcccc ggcttccctg
     4441 actccgtgct cgcccacgca ccgcagctgc cgttcgagca cgacctgtgc cgcgcctgga
     4501 acgtgccgga ccgcaccgcg gtccagcgga tcgccaccca cagcgaggtg ccggcgctca
     4561 tcatcaccgg caccttcgac gcgaagaccg gcgccggctg ggggccgttc gccggccgca
     4621 cgctgccccg ctcgaccgcc gtggtggtcc ccgggatcac ccactgggtg gtgccccagg
     4681 agccctgcgc cgcctcggtc ctcgtctcgt tcctggcccg gccgaccgcg cccgacacgg
     4741 gctgcgtggc gggtgtcgtg cccaagccct tcaccatcat cccctgaccc ggaatccgga
     4801 ggacgcacga tgtcccctcg cacgaccccc cgtcggcgcc ccgtgaggct cccggcgacg
     4861 ctggcgggag ccacggcagg cgccctcgtc gcaggcctcg tcgcgatgcc cgcgcacgcc
     4921 gagtccgcga ccgacggccc gcaccgcccg atcggcacgg tcgcccgcac ggtgggcgac
     4981 gcccgcttcg taccgggccc ctgccccaga acggcggacc cgatcccgga cctcgcacgg
     5041 gcccgctgcg gcaccctcac cgtgcccgag aaccgctcca agcccaaggg cgcggacaag
     5101 cccaagggag ccgagggcgc cgacgagcac aaggcacccg acaagcccaa ggcatccgac
     5161 aagcccaggg agtccggagc ccaccgggga cggacgatca ccctcgccgt cgcgatcatg
     5221 cccgcggagt cccgcacccc cgcgcccgac ccgatcgtct ggttcgccgg cggacccggt
     5281 gatgacgcgg tgtccgagat cccgatggct ctcgcgggcg gcctgaaccg cgaccgcgac
     5341 gtgatcttca tgtcccagcg cggcacctac tcggccgacc cggtgctcac ctgtccgaac
     5401 atcgacgagt tcaacgcccg cgccctcggc ctcgtctcca acgcgcccgc caccggccgc
     5461 ctgcacgtcg aggcgacccg cgcctgccgc gaccgggtgg acggcctggg cgccgaccgc
     5521 agcacgtacg acgacatcga gagctcggcc gactacgagg ccctgcgcag gacgctgggc
     5581 gtcaggaagt ggaacgtctt cggcatctcc tacggcaccc acctggcgct caactacatg
     5641 cgcctgcacc cgaagggcat caggtcggtc ggcatcgacg gcgtcctgcc gccgtccctg
     5701 gccggcggag ccgtcacctg gaaggccgcg cgcgagggct tcgacggtct gttcaaggcg
     5761 tgcgcggagc agcccgcctg caacacccgc tacccgaacc tgaaggccac gttcctccgt
     5821 ctcgtcagtg agctggaggc cgagccgatc accaccaccg tcacggtccc gacgcagccg
     5881 gagccggtga aggtcgtcct ggacgggagc aacctggtcg gctggctgac ctcggccacc
     5941 cacgtggcgg ccggagtgcc ccgctccctc gacgagctgg cccacggcaa cccgcagcgg
     6001 atcgccgagc agctcgcggg cggcaagtac agcccgcagg ccatcggaag ggtcgcccac
     6061 ggactggtct acggcgtctt ctgccgccag tggaccccat acgagagccg ggccgacatc
     6121 atccggggcg gccgccgcgc gttcccgtcg ttccccgggt cgatgctggc caacgcgccg
     6181 cagctcgcct ggctccacga cgactgccgt gcctgggacg tccccccggc acctgcctgg
     6241 atccgggacg tgacccgcag cgacatcccg accctcgccc tgtccggcgg cttcgacgcc
     6301 cagaccgcgc ccagcaacgg ggcctacgtg gcccgtacgc tgagccggtc ccacgccgtc
     6361 acggtgccct acgtggccca cgtggtcttc gccgactcgc cgtgcgcgca gacgatcacc
     6421 acctcgttct tcgccgaccc cgccgcgccg gacacccgct gcctggccgg cctccagccg
     6481 ccgcagttcg agatcgcccc ctaggcgggc gggttcggca ccgcgcgccg gagacagacc
     6541 ccgccgcccg gcccccgctc gtacctgagc gggggccggg cgtgtgtcgt cgcgggcgcg
     6601 gcattggccc gaccgggtcc tccgtacggg cgtccgccgg tgtcgtcccc cagcggaccg
     6661 ccgtcccggt gaggatcggt ccatgggcgt cgtcctgccg gttctcttct cgctgttcgc
     6721 cgcgttcagc aacgcgctgg ccacggtgct ccagcggcgt gcggcgctca ccgtcccgca
     6781 gtccgactcc ttccggcccg gactgatcct cgacctgctg caccgccccc tgtggctggc
     6841 cggcatcctc gccgtcatcg ccgcgggcgt cggacaggcg gcggccctcg cgaccgggcc
     6901 gctcgccctc gtgcagccgc tcttcgtcct cgaactcccc ctcgccctgc tgatcgccac
     6961 cctcctgaca cgcgaacgac tgcccgcccg gctctgggcc gccgtggcgg gggtcgtcct
     7021 cggcctcgga gtggcgctcg cggccgcctc gcccaccggc aaccgcaccc atgtcgcact
     7081 ggaccgctgg gttccggtcc tcgtggcgtg cgccgtggcc gtggtcgccc tcgccgccgt
     7141 cggactgcgc agaccaccgg ggcgcgcacg ggccggctgt ctcggcgccg cgacggcgat
     7201 ctgctacgcg ctcaccgccg ccctcatgaa gacgtccatg cacatcctcg gcgacggcgg
     7261 catcggcgcc ttcctgacgg cctggcagac ctacgccttc tgcgcggcgg ggatcgccgc
     7321 cctgctgctg ctcgaacacg ccatgcaggg gggtccgctc gtcgcctcgc agcccgccct
     7381 caccctgggc gacgccaccg tgagcctgag cctgggcgtc ctgctgtacg aggagcacgt
     7441 acgggcgggc tggtggctgc tgccccagct cgcgggcatc gcactcatcg tcctcggggt
     7501 gttcgcgctg gcgcgcagcg gcgtcggcac gtcctgacca cacactccgg acggtgcgtc
     7561 acgccggggt gtgcggccgg gacgtgccga cagcggtgtc actcgggacg gttgaagcgc
     7621 cgcgcggccc agagcagcgc gaggaggccc gtggcgagca ggaggccggc ttcgaggggc
     7681 aggggcggct gacggcccgc ccatgcgatg ccggtgacgg cctgctggtc cggtacgagg
     7741 tgggtgatgc agcggcggag caggtccacc gcgtaggcga gcgggttggc ggcggcgagg
     7801 gtctgggccc agccgggcag cgtgtgcagc gggaagaagc cgccggagag gaacagcagc
     7861 ggcatcatga tcagcccgag gagcgtgtgg aacgtctccg gcctgcggag ggtgacggcg
     7921 agggccagag ccagagcggt gatggtgaac gaggccagga tcatcccgcc gaggagcagg
     7981 ccgaggagga gcgggtcgta cggcaggccg accgtgcccg cgaggcagag cagtacggcg
     8041 ccctgcgccg cggcggtgac ggtgccgccg acgcagtgcc ccaggagcag ggtggcccgg
     8101 ctgacggggg ccatgaggag ctcccgcagg tagccgctct gccggtcggt gatcagacgg
     8161 atgccgacca tgatggccgg tgtctgcacc gtcatcatca gcatgcccgg gaagaggtac
     8221 gtctggtagc cgacccccag ggaggaccgg gggatgagcg cggcgaggcc gcctcccagg
     8281 atgaggaggt agagcatcgg gtggagcagc atcagcgcgg tgtgggtgcg ctggcccgcc
     8341 aggcgcagca ggtcgcggta gaccagggcg tggatcgcgc gcagctcgtg ccggagccgg
     8401 gccggccacc cgctcccgtg ggtctccgcg ttcccgaggg cccccgaggt accgggcgca
     8461 cccgggtcgt ccggagtcgg gggagtctcc ggggacttca ccgtgaggtc ggtcatcggc
     8521 tgccgccggt ttccgacgcg cccacgcccg cggtggtggc ggccggcgcg ccggccatgg
     8581 ccttcgcgtg gccgggcttg gcggcgtcga ggctgcggcc ggtgtggtgg aagaagacgt
     8641 cgtcgagcgt gggcggcgcg gcggaagcgg cgtggacggc gatgccgtgc cgttgcaggg
     8701 ccgcgcacag gcgcgggatc caggtgctgc cgtccggcag ccgcagggag actccgtcgc
     8761 cgtccgcggc gacggtccgg tccggcggca cgatgccgcg cacgacccgc cgtgcctcgg
     8821 tgtcgtcacc ggtacgcagc acgaccaggt cgtctccgat cgcggccttc agcgcgaggg
     8881 gcgtgccctg cgcgaccacg cggccctggt cgacgatggc gaggcgatcg cagttctcgg
     8941 cctcctccag gtagtgggtg gtgacgaaga gcgtgctgcc gtgccggtcg cggagcgcgc
     9001 gcagatgctc ccagacctgg gcgcgggcgt gcgggtcgag tccggtggtc ggctcgtcca
     9061 ggaacagcac gcggggggag tggagcaagg cccgcgcgat ctccaggcgg cgtcgcatgc
     9121 cgcccgacag ggtgcgtacc ggggagcgcc gtcggtcggt cagcccggcc gtctccagta
     9181 cctccgcggc gcgcgagcgg gcgtggcgac gggcgagccc gtagagccgt gcgtggatgt
     9241 ggaggttctg ctcggccgtc aggtccgcgt ccagagcgct gtgctggaag agcatgccga
     9301 cgcgtcgccg tacctcgtgg ggccgctcga ccacgtcggc gccggcgacc gtggcgtgac
     9361 cggaggtggg gcgggccagg gcgcacagca cggcgatggt ggtggacttc cccgcaccgt
     9421 tgggcccgag gaaggcgaag gtctcgccct gcgccacgtc caggtccagg ccgcgtaccg
     9481 cgtgggtggt ggtgccctgc gggccggggt agctcttgac caggccgcgc atgctgatgg
     9541 cgggctcggg agcgtggccg gcggcgggcg ggtgcgcgac ggcttccgcc acgagggctg
     9601 cgggggcgag gccgtcgaca gcggcacgct gcggcgcggg gtcgggtcgg tcctcatcac
     9661 cggtgggtgg ctgcatgcgg tcgcgtcctc gtctacgggt tcgccgtccg tggccgtcct
     9721 cggccacgcg ggcgcgcgga agggggcatc cggccggcgg cttcccgggt gggccgccgg
     9781 ccggatggtg ggtgtctgtg ctacgcgcag ctgatgccga tacagaccgt gttgaggagg
     9841 gtcagcaggc cgacgcactc acacgtcgcg gcgaacggcg ctccgtcgac accgacgggg
     9901 tcggtctccg gaagggcgtg gaggtgggcg agcagctcga tgtcctggtt ctccatggga
     9961 ttctccttcg ttgttgaact ggcggcagac tccctgccgc tcagaccggc agctggacca
    10021 tccagtgccg ggggtcggtg tggcggatcc gcaggaggaa ggcgaggatt ccggcggatc
    10081 cgtcgctcca gctggtcgag acgtccccgt actcgttggg gaagaccacc tgggcacggc
    10141 gttgggccct ctcgctgacg atgaggcggg ccaggtcctc ggccatggtc cggtggacgg
    10201 ggtcacccgt cgcgtccgcc atgtcgagga ggaagtcacc gttgcccgcc aggccgtggc
    10261 actgggcgag ggcggcgcgc gaagcgcgct cggtgacggc gtacgtactg cggcgggcga
    10321 ggtcggcgta tctgtcgtcc ccggtggcct gccacagccg gacgaggaac gtcccgatac
    10381 ccgccgcacc atggcaccag tacggcgccg tgggcaggtc cccggcctgg gcgggccact
    10441 gggccgcttc gcccgtcagc acggcgtcgg ccaccagctg ctcgccgacc tcgaccgcga
    10501 ggtccttgtg ctccgggcgc cctgagacgc tcgcggcggc cagcaggaag cagccgatgc
    10561 cggagcttcc gtgggcgaag ccgaggtagc gtttgccgcc ctccgacgag gctgcctccg
    10621 cgggaacggg ccagctcacc ccggacgggt cacgccgcgc cgcggcgacc agccggtcgg
    10681 ccgcgtcgac ggccagttcg gcgaaccgcg ggtcgccggt gcgctgccac aggtggaccg
    10741 cggcgagccc gctgcccgcg ctgccgtggg tgatgtcgtg atggggcgtc acctgctgcg
    10801 gggccagtgc cagagccgac gcgtgctcca tgagcccgcg gtcgtccacg gcccgcccgg
    10861 cgtcgtacag ggcccaggcg gtgccgcgtc cgccgaagtg caggccgggg cgcggggaac
    10921 ggatatcggc ccggtccgcg atccagcggc ccgcggtgga gatcagctcg ggcagacgct
    10981 cgtcaccggt gagttcccag taccgcgtca gcacggccag gacaccggcc gcgccctgct
    11041 ggacggtgca ggggtcggac tccccggcca gggtggacac gggccacagg cggtgcgggt
    11101 ccgcgggagt catcgaagcg acgagatgct ccaccatgcc ggccacggcg tggtccacgg
    11161 tcccggccgt gtcctgcggc acgtcaccca ggccgccctc agggcggtcc gcgtgccgga
    11221 cggcgtcgct cagtctccgc cgaggctccg ccttcccgag ggcttcgcgc gcccgggcgg
    11281 ggtcccaccg ctcggccgga tcgtccttca tcagcccgag gatcatctcc gcgaggccgt
    11341 cggacagccg gagcggttcc gcacaggcgg tcagccatgc ggcgagccgc tgctccgccg
    11401 tcctggtcgc cggctcgtcg ggcagcaggt tcggcacctt cccggccagg acgaagcagg
    11461 cggtggcacc gaggctgtag tagtcgcccg tcgggctgac aggtgcgtcg tccagccgtt
    11521 ccggggcgct gaagccgggg gttcccacgc gggtcggcag ggccgcctcg tcgtcgagga
    11581 cggcgagttc gaggtcgatg aggcgcagtt cgccgtcggg acggaccatg acgttgccgg
    11641 gggtgaagtc gcgcaggaca cagccttgcg cgtgcgcagc cgcgaccagg tccacgaggc
    11701 gttcgacctg ggccggcgcc tcggcgcggt agcgttccgc tccggcgtcg cggaagtgct
    11761 cggcgaccca gttccgcagg gtgatccccg gcacttcctc ctgggccagg aagaggtgcc
    11821 cggcgtgctc gaacaacgcc agcggctccg gagcgagccc ggtgcccttg agcttctcca
    11881 ggatccgggc ctcggcgcgc agccagtcgc ggacgtcgca gccggaggcg tcggcctcca
    11941 cgtgcgggcg ggcttccttg atcaccacgg gggcgcccgt accggtgtcg gtgccccggt
    12001 agaccccgcc cttgttggtg tgccggatgg cctcccgtac cgagaaccgg ccaccgagca
    12061 gcaccggagt ccttaccgag gccgccccgt ccttcccggc ggtgccttcg ctcccgctgc
    12121 ttccctccgc cgagcggggt gcgacaggaa ccgtggcggg gaaggggctg accgcccagg
    12181 acggcggaga gtactgcccg gtgcgcttgt cctcgacggg gttgccgtcg gggtcctcga
    12241 tgaaccacac cagcagaccg tcgtccgaga gccgccgccg gccgacgaac gagccgtacc
    12301 ggtagtgcac cagcgagtgc acggcgtacg gctggtcgga caggatccgg ggcccggcca
    12361 gacccgccgt ggccccgtgc aacgcctggg cgagcagggc cgcctcggcg tcggagcgag
    12421 ggtagacggt gatgaacttg cccgagcttc cccggggcgt ggcacgggag ttgagcgcac
    12481 tcacctggtc gagcgaccgg gcgaacttga acgccgactc ctcccgcagc agcacgtcca
    12541 gggccttctc gaggacagcc ggcgcggagg cggccgtcgc cgacacgtgc agcttccacc
    12601 cctgctcgcg ccgtgtcccc gtccccggtg tgacacggca ccacatctcg tccgagtcgg
    12661 ccgcccagcg tgcacccgta cccgtggcgt gcagcgcctt gcggagaagt ccttccagtt
    12721 caacttcggt agcctggctc gtcatcggtg tccttctcga cagtgaggtc cgctgatcgg
    12781 aaggttcccg gcggcatatc ccgaccaaca catcacccct cgtattcact tgatccagcg
    12841 agcgcacagc gcgacggcgg cgtcgacgag gtgcgcccag cgcagaagga ggctcacgaa
    12901 taccggcggg tacgcctcag ccgtgcggtg accgcgtcac cgcacggctg agtgcgcgca
    12961 ggcagggagt ggggagaaaa ggcgaggtca gcgcggagcg cgccggccgg acgcttcgct
    13021 acggcaggat ggagtcgacg tatccgccgt ccacgcgcag tgcgccgccg gtcgtggcgg
    13081 acgcctgctc ggaggcgagg tacaccacca tgtgggcgat ctcctcgggc tcgatgagcc
    13141 gctggagcag ggactgcgga cggtactcgc gcatgaagac gcgctgcgcc tcgtcccacg
    13201 gcagcgaacg gtccaccagc tcgtagacga actgctccac gccgcccgtg tgcgtggggc
    13261 cggcgatgac ggagttgacc gtgacaccgg tcccggccgc ctgcttggcg aagccgcgcg
    13321 agaccgccag aagagccgtc ttggacatgc cgtagtggat catctcggcg gggatgacca
    13381 cggccgagtc gctcgcgatg ttctggatcc ggccccagcc gcgctcgctc atgcccggga
    13441 ggtactgacg gatgagcctc accgcggcca ggacgttcac ctcgaagtag cgccgccact
    13501 cgtcgtcgct gatctccagc gggtcggcct cgccgaagac gccgaggttg ttcaccagga
    13561 tgtccacgtg cggcagcgcc tcggcggcca gccgcgctcc ccgctcggtg gtgacatcgg
    13621 cgacgaccgg gaccagatcc gcgtccggga cctcggcgcg cagggccgcg acggcctgcg
    13681 cgacgcgctc ctcggtccgc ccgttgacgc cgacgcgggc tccggcccgg gccagacccg
    13741 cggcgatcgc ggcaccgatc ccctgggtgg agccggtgac cagcgcggta cgtcgtgtca
    13801 gatcgacgag catgggggcg ggctcctcac agaacgcggt gggtgcgtcg gtcacccctg
    13861 tccgttcccg tacccgccgg gtggcacgga gcatcaggaa accccgcacc acccgccgta
    13921 cggcccaatc gacggacggt cccatcgagg cacggcccga tcggcgcacg gccactcgac
    13981 ggacggcccg atcggcgacg gtggcgccgg cgggatcgct gctcccgccg gcgccggccg
    14041 ggctcagtag cggagcagcc ccgcgtcggt ccgttcccag gccgcccgca gctcggcgag
    14101 tcgcgccggt tcgagcggtg cccggtccgc ctgctcccgg gagtcctcgg acaggtcgaa
    14161 gagctggtcg cgaccggact tgccccggta gtacttccag tcgccgcggc gcagcgcccg
    14221 ctcgccccgc acccgccaga agaggtcacg ctccggcacg tcggcgccgc ggagcaggtg
    14281 cccggcgagg ctggtgccgt cgagggggta cgcggggtgg gggcgggctc cggccagctc
    14341 gagcagggtc gccgtccagt cgggggtgaa caccggcagg tcgctgacct gaccgccgtc
    14401 gatccgggcg ggccagcgga ggatcgacgg gacgcggatg ccgccctcct ggagcgagcc
    14461 cttgttgccg gcgagtggcc agttgtagga gaagcgctcg ccgccgttgt cgctggcgaa
    14521 gaagacgagg gtgtcctgct cctgcccgga gcgcttcagc gccttgagca cctggccgat
    14581 cgagcggtcg agatcctcga ccatctcctt gtacttctcg acggagccgc cgtcctggtg
    14641 ccacagcgcg gagcggtcgc cggccttgat gcggcggacg atctcgtcgc tcgcctcctt
    14701 gtcgccgtcg gctatccagg gccagtgcgg ggtggtgaag ttcaggttga gcagccaggg
    14761 cctgtcgtgg tcgcggctga cgtactcccc ggcgcgctcg gtgaggatcc gggtgtagta
    14821 ccgcaggtcc ttgtactcgg cgtccccctc gtacaggtcg tactcgccgc cgagaccgag
    14881 cttcgagtag tactcgagcg ctccgccgaa gttgccgaag aactcgtccc agccggaacg
    14941 cgtgggggag tagtcgggca ggtagccgca gtgccacttg ccgatgaggg cggtggagta
    15001 accggagtcc cggaggagcg aggcgagcgt cggatgggtg ggttccaggc cgacggactt
    15061 gtcggcgatc ggctcggcga gcccgccctt cgtacggccc gggtagcggc cggtgtagag
    15121 gctgaagcgg gtgggggagc aggtcgcgga accggagtag gcgtcggtga agcggacgcc
    15181 ctcgcgggcg agacggtcca ggtgcggtgt gcggatgtgc ggggatccgt acgaggagag
    15241 gtcggcccag ccgaggtcgt cgcccaggat gaagaggatg ttgggccgtc gcgagtggcg
    15301 gcgcggatgc gcggcacgga aggggcgctc ccgcggttcg cccgcgggag ccgcgtgggc
    15361 ggcggacgcg ccggctccca gggcggcggc ggctgcggcg ccggcggcga ccccgccgag
    15421 ggcgcggcgg gacaggggcg tggacatacg ggactccagg agggcgtgca ggcatgcctc
    15481 cggggctcgg tggacggggt gagcggagga agcgtgggtg cggggtgagt gggaaggacg
    15541 cgaccggtca gcggcggcga cagacagcgc tcgcgacacg gacgaggtcc acgtgtcggt
    15601 gttggacgtg ggtgaccgag cggtcacgca agggctgcat ggggcaggag tcttgtcgag
    15661 gtgtcagcgg ccgtcaacgg cgtcggggca ggtcgacgcg cgtagttcgc atgatcgaaa
    15721 cgcgagcggc tccgcacgcg agccgctccg tacgcaggcc gctccgctgc ggcaggtgtt
    15781 cggtggggcg ggcgacgacg cgtcgggcgg gagcgtccgt accgctcccg cccgacgcgt
    15841 cgtcgcccgg tgggcgctcg gggtacgtgt cagccgacgg gcgcggccgt gtcgtcggcc
    15901 tcggtgacgg ccgggtggat cgtctcggcc ggggggtcgg ccgtgcgccg cacccacagc
    15961 cagtacaggg ccgcggtgac cacgagcccg acgatccacg agatgtcggc gccgtcgaga
    16021 cgcttggtga tcgcaccggt gtacagcttg gtggccagga acgggatctg gacggcgacg
    16081 cccacggcgt agcaggtcag cgcggtgacg ttccagcggc cgtagcggcc ggccgggtcg
    16141 tacagggcgg ggatgtcgac gcgctcgcgg gagaccaggt agtagtcgac caggttgatc
    16201 gcgctccacg gcgtgaacac catcaggatc agcagcacga agttcttgaa gttgtcgagg
    16261 aagtcgtcgc tggcggccag cgcgatgacc atcgacaccg cggtgaagcc gacgatgtag
    16321 gcggcgcggg cgccggccga gatgcgcgag cggccgtcga aggcggtgac ggtggtcagg
    16381 atggacatga agccgccgta cgcgttgagg cagttgaccg tcagcttgcc gaccacgatc
    16441 accaggtaga cgaggacggc caggaccgcg ggtccggcca ggtcgccgag gaagcccacc
    16501 tggtcgctca ggaaggtctt gccggcgacg gcggcggtca gccctcccag cgtcatggcc
    16561 cactgggagc cgatgacgga gccggcgaac gtggaccaga aggtcgcccg cgtgctggtg
    16621 tcgcgcggca ggtagcgcga gtagtcggcg acgtacgggc cgaaggtcag ctgccatccg
    16681 gcgccgagcc ccacggcgag gaggaaggtc gccgtctcga accccttggt cccgacgtgc
    16741 gcgccgacgt cgtactgcgt gaacagccgc acgaggaggt agccgaggcc gaggacgccg
    16801 acgaccgtgg cgacgcggcc cgcgatgtgg atgaggcggt agccggtgac cgcgaccacg
    16861 gcggtcaggg cgccgaagac gaggatgccg gcgttcgtgt tgccgatgtg cagcatctcg
    16921 gagagcgcct ggccggcgag cacgctgccg gtcgcggcga agccgaggta catgaggatc
    16981 accagcagca ggggcaggac cgccccgtaa acgccgaact gcgcccggct ggagatcatc
    17041 tgggggacgc cgagccgcgg tccctgggcg gagtgcagcg ccatcacgat gccgccgagc
    17101 acgtttccga tcagcagcgc gggtatcgcc cacagcgcgt cggcgccgaa gacgacggcg
    17161 agtgcgccgt cgacgatcgc ggtgatctgc atgttggcgc cgaaccacag agtgaactgg
    17221 ctccgcggcg tgccgtgccg ctcggcgtca gggatgactt cgatggtgcg cgtctccacg
    17281 gagagtcgct ctccgggggt gtgctggacc ggcatggtga agacctctcc cgcagcggtt
    17341 ccggtgtgtc cggacgaggc gcagccgttg acgcgtgact gcgtgcgccg aatctcgcat
    17401 gggtctcaac aggtatcaag atcttgaatg gagaatttca aataggttcc gctgccgagt
    17461 cgacaccttg cgtacccccg tcggccgcgc gtgcacagga cgtccagtac ggttttttgc
    17521 cggaccggca agaatcgcgg cacgcgagcg gccggatggg catggtgggg tccgtgaccg
    17581 agaacaccga aaacaccgca gcgggatcgc ccgcgtccca cgccctcacc cccctcgtcg
    17641 acgcatacgt cggagacccc gcggtacggg cggaatggga cgaccggtac ctcgaccggc
    17701 aacagctctg gagcggccgg ccgaacggcg cgctcgtggc cgaggtcgcc gggctcaccc
    17761 ccggacgcgt cctcgacgtc ggctgcggtg agggcgcgga cgccgtctgg ctcgcgcgcc
    17821 gcggctggga cgtgaccgcg ctcgaggtct cgggcgtggc cctggagcgg gcggccggac
    17881 acgcacgcga cgcgggcgtc gccgtccgct gggtgcacgc cgcactgacg gacgcggccc
    17941 tcccgccggc ctcgttcgat ctggtctccg cgcagtaccc ggcgctgctg cgcacccctg
    18001 acgccgctgc cgagcgggcg ttggccgggg ccgtcgcggt cggcggtgtg ctgctgctcg
    18061 tccaccacgc cggaatggac acccggccgg cggacgagag cggcttcgac ccggccgact
    18121 acgtctggcc ctcgatggtc acggcggtcc tcggtgacga ctgggtggtg gaggtggacg
    18181 aacagcgggc ccgcgtggca cccgacggcg gagccggcgc gcaccacacg gacgatctgg
    18241 tgctgcgcgc ccgccgactg cgctgagcgc gtctccccca ccgaggagca ccaagatcac
    18301 cccggtccgc ggcgggggca ggagtcgaac tagtcttcgc tgcatggcct tgcgacctga
    18361 cgagttctac gaccacgcgc tcgccgccgc cgatgccgag catcggctgc ctctcgcgcg
    18421 catgacgggg tggagcatca gccccttcga ggcggaaggg ctgcgcgtct cgcccctgcg
    18481 ccctccggtg ctgcccgagc ccccgcgaca cggcgaggac ccgtccgact gcgcgtcgtg
    18541 ccgcgaccgc ggtgacggca tctggttcaa cgaccgttgg cggctcacgc ggatcgaggg
    18601 agtcggcgtg ccgctcgtgc tgatgctgca tccgctcgag caccacgaca tggcggacct
    18661 gcccgacgag ctggcggccg agttgggggt cctgtccacc cacatcgtcc gccacgtgca
    18721 ggccctgccc catgtctccc gggcccacgt ctaccgcatc ggggacggcg gagcgcacct
    18781 ccacatctgg ttcttcgccc ggcccgaggg acagacccag ctgtacgggt cgtggatgcc
    18841 ggtctgggac gacctgctgc cggagtaccc ggcagacgtc gcggacgcgg acgcggcggc
    18901 cgtggcggac gcgttggtgg cctccgccgg cgggagtcgc acgcctgccg acgcctcgac
    18961 acccgcctga tcatccaccg acaggccgga gggccgggcc gacggggagt cccccgccgt
    19021 cccggccctc cggtgcgttg cgcgtcagca ggcggatacc cacaggtgcg acccgacccg
    19081 gtcgttgacg agttcgccct ggccgtgacc cgggctgaag aaccgcaggc cggacgcgcc
    19141 gaggtcggga agcgagtgcc cctggtggag gcagacccac gagccgttcc agtcggtgtc
    19201 gcggtagagc ttcacgtcct cggcgacgcc ggggtagccg ttgttccaga cgtccgagac
    19261 cttgtcacgg cagccggccc agttggcgtt cgcgctgttc caacggcagt ggaacccgcc
    19321 cgcgtggggg tgctcccagg cgtagaggaa gccgtccggt ccgggtgccg cggcggggac
    19381 gacggcggcc ggtgccgtgg cggcgccggg gagggcggcc tcgggcacgg cgccgcgggc
    19441 gtcggcgacc ggggcggtca gcagggcgag ggctccggcg gtgagtgccg tcgcgagggc
    19501 gcgagagatg cgcatggtgt ttctccttct cggatgcgat gcgatgcgat gggatgcggt
    19561 gactcggagg atcggtccat ggatcgatgg gccgatgggg gtggatgggt ggatgggtgg
    19621 atggggtggt gccgtccgct gttcgtgccg cggtcggcgg gccgccgcgt gcatgcggcg
    19681 cgcggcggag cagaaggggc aggcggatca ggcctgcggg gggtcgccga ggatccggcg
    19741 ggcacggggc agcgcggcgg ccgtcagcct gtcccgcgtc tcgatgtccg cgcggtactc
    19801 ctcggcgagg agccggtcgt ggtgggcgtc gaggcgccgg gccgtccggg acagtcccga
    19861 ctccgcggcg caccgcacct ctgccagggc gagccggatc tcgtggtcct cgggaaaggg
    19921 gcgtacgggg gagagcgcgg cggcacgggc agccgccggc gtcgcgaagg cgtacccgac
    19981 gcgccccatg cagcgccgcc acactcccag gctcttctgg tagccggagt cggccacgac
    20041 ccggctccgg aggatctgcc gcagcgtgcc cacgcggatc gatgaccgga accaggcacc
    20101 gaggtctccg tacagctggt gctgggcctc cgcgacacag ccgcgatcgc tgcggcgcat
    20161 ggttccgccg ccggggaggc gtaccgtcag cccgtccggg gaggggccgt tggcggtgac
    20221 cagcgcggcg gccttgcggt ccgtcggcag tgtggcgaag taggcgcggt tcggatcgct
    20281 cttcgcgagg gccgcacgct gccgccgcag ctcggcaccg tagccgtgcc gcagggccca
    20341 gcccgcgtcg tcgacgacgt acgggaagag cgtggactcc gtctcgtcgc cgagcgggaa
    20401 cacgcggtac gtgaatccgt gccggcccat gcagtcgcgc agcagccgtt gttcggcgtc
    20461 gtgcagcagc cggtcgtccg cggtggccac cgtcgtggcg atgaggcgtg gtggaggtgg
    20521 ccgttcgccc gccgaaggcc tgccggggcc cggcagggcg gtgacggaga gcgcgatcgt
    20581 cgtacaggcg accgccgcgg cgacggcgag cagggggcgg cgggcatggc tgttcctggg
    20641 catgaggtct cctgcggtgg atgtgggggt gcggtcccgt gacggtccgt cggtgccggt
    20701 cgctgtgcgg gcaccaggag gcgtaggcgg tcgggacgtc cggtagaggc gtcggcaccg
    20761 agcggtgcgg cggccggaca accgaagtct gtgccgctcg gcgagcgggc cgcaagcgtg
    20821 tcccgggtgc ttcggcgaag tcgggatgcg gtgggatctc cacctctctg acctgcgggg
    20881 acgtccctgt cccgggacac gggtgagcgc gggacagggc cggggggcga accgtacggc
    20941 catcggggtg aggcaccggc agcgccctcc cggccgtccg gccgaccgcg cagcgccccc
    21001 tcgccggtcg ttccgtcgtc ccgtcggacg cgcaacgtga cgacctccgc gtcgttctcg
    21061 tggtgtgctc cgcgcctcca gggcgtgggg gaggggagcg tcgacggcgt cgtccgcgcg
    21121 tgcgcggcga ccggagcgga aggagtcgat cggtgcacga ccggaccacg tcaggaggcg
    21181 gaccgttccg ccgggcgggc gcggggcgcc gcgggcgcct cgcagcggtc ggccgggggc
    21241 ggaccgctct tcgccgccga ggcttcgcca cggccatggc ggcgttgggc gcggccgcct
    21301 gtctcgccgc gttccccgcc ggggccacga cgcccgatcc gatccgggct ccggcggccg
    21361 taccggactc ggtccggggc cggacgacgg aggaaccccg gtttctcccg gccggtgccg
    21421 ccgctgcctc cccgaccgca cccgtcctcg accgggagtt cgccgacccg gacgtcgtgg
    21481 aggtcgacgg ggtgttccac gcctacgcca ccaacgtcgc cggccggcac gtccagcacg
    21541 ccacctccac cgacctggtc cattggacgg tcgacgagaa ggacgtcctg ccggtgccgg
    21601 gcgactgggt caagcccgac cctccgcgcg acgtctgggc ccctgaggtc ttcgacaacg
    21661 gcgacgggtt caccctccag tacacggcgc gcgaccgcgt cggcgggcgc cagtgcatcg
    21721 gcgccgccct ggcgtcctcg cccgacggcc ccttccggcc ggccggggac gccgccctgg
    21781 tctgtccgac ggaggcgggc ggcgcgatcg acgcgtcgag ttacacggag aacggcaccc
    21841 gccatctgct ctggaagagc gacgggaact gctgcggact ggacacctgg ctccacatcc
    21901 agcccgtctc gtgggacggc acgcgcgtca ccggcgaacc ggtccggctc ctcaggcagg
    21961 accgcgcgtg ggagggcggc ctcgtcgagg ccccgacgct ggtcaagcga gacggccgtt
    22021 acgtcctcct gtactcggcc ggcgactacc gcaccaccgg gtacgcgacg ggctgggcca
    22081 tcgccgacgc gctcaccggc ccctatgtga agggggacga gccgctcctg accacggact
    22141 ccttctcggg aaccatcggc ggaccgggcg gccaggacgt cgtgaccggc cccggcggcc
    22201 gggaccgcat cctcttccac ggccggggcg ccgacccctc acggcgcgcg ctgtacgtgg
    22261 cggacctcgg cttcgcggac ggccgcccgg tcgtccgggg cagcaagacg ctccaccagg
    22321 cggagctcgc gcgggtgcac cgggcgacga tccgcgaggc gaaggacgcg tggggcggcc
    22381 gggccgtcgg gcacatcgac gaaccggaca gtttcgtgga gttccgggtc tacgcggcct
    22441 cctcggggcc gcacaccctg accgtccgct acggcaacgg ctcgctggac gcggcgggtg
    22501 cgccggccgc cgcgacgcac ggactgacgg tcaacggcgc ggccgtcggc gtcgtcgaat
    22561 acccgtacac gggctgggac gcatggcagc cgcgtgaggt cccggtggag ctgcgggagg
    22621 ggtggaacac tctccggctg tcgaaggggg agcgctacac ggagctggac gccgtgcagg
    22681 tggcgtagac ccgccctaca tgccccgccc gggccggctt cccccccacc cggcccgctt
    22741 ctccc
//
