LOCUS       NZ_LIVV01000002        10393 bp    DNA     linear   CON 28-MAR-2024
DEFINITION  Streptomyces sp. CB02009 scaffold2, whole genome shotgun sequence.
ACCESSION   NZ_LIVV01000002
VERSION     NZ_LIVV01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CB02009
  ORGANISM  Streptomyces sp. CB02009
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 1350328)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1350328)
  AUTHORS   Yan,X., Ge,H., Hindra,F., Yang,D., Huang,T., Crnovcic,I. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-AUG-2015) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC Genomics Workbench v. 7.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905825.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:41:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,214
            CDSs (total)                      :: 8,139
            Genes (coding)                    :: 7,984
            CDSs (with protein)               :: 7,984
            Genes (RNA)                       :: 75
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 51 of 155
            Pseudo Genes (incomplete)         :: 117 of 155
            Pseudo Genes (internal stop)      :: 15 of 155
            Pseudo Genes (multiple problems)  :: 26 of 155
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:06:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 467764
            Orig. end                         :: 478157
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LIVV01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10393
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="5"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10393
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10393
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5393](+)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5393
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     misc_feature    70..83
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.61"
                     /tool="antismash"
     gene            complement(281..1192)
                     /locus_tag="AMK27_RS09490"
                     /old_locus_tag="AMK27_09310"
     CDS             complement(281..1192)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015038015.1"
                     /locus_tag="AMK27_RS09490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_09310"
                     /product="LysR substrate-binding domain-containing protein"
                     /protein_id="WP_073905908.1"
                     /transl_table=11
                     /translation="MQFQQLLYFVAVAETRHFTRAAERVHVSQPSLSQQIKALEQELGA
                     ELFSRARGNITLTDAGEALLPLARRILADTETARIEVQELAQLKRGRVRLGATPSLCTG
                     LLPDVLRAFHDLHPGIELLIEEGGSHDLVRELARGALDLALVVLPLPSPSPALTTVELL
                     REDLVVVSSASAPAPRRPVRITDLRDQPLVMFRHGYDLRELTVAACRAEGFEPTFTVEG
                     GELDAVLGFVRAGLGLAVVPAMVAARAGRDLRVTALARPGLRRTIALAHRSDVAPPRAA
                     RELQRMLLASRRAGPDRTVGTV"
     misc_feature    1262..1276
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 25.68"
                     /tool="antismash"
     gene            1388..2014
                     /locus_tag="AMK27_RS09495"
                     /old_locus_tag="AMK27_09315"
     CDS             1388..2014
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018536741.1"
                     /locus_tag="AMK27_RS09495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_09315"
                     /product="succinate dehydrogenase"
                     /protein_id="WP_241847458.1"
                     /transl_table=11
                     /translation="MAVSGLLMLGYLVAHVAGNLKVFFGPEEFNAYGHWLRVMGAPVLH
                     HEWALWLVRIVLLAAVVAHAVSAYQLSRRDVKARPTAYVHRRKRSSYATRTMRWGGIIL
                     ALFIVWHVLDLTTGTVHPGGFEEGKPYQNVVDTFSTWYGNVIYIVAMLAVGLHVRHGFW
                     SAAQTLGIGSARRERLLRGLADTLALVLTAGFISVPVAVMTGVVS"
     gene            2016..3962
                     /locus_tag="AMK27_RS09500"
                     /old_locus_tag="AMK27_09320"
     CDS             2016..3962
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386402.1"
                     /locus_tag="AMK27_RS09500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_09320"
                     /product="fumarate reductase/succinate dehydrogenase
                     flavoprotein subunit"
                     /protein_id="WP_073904699.1"
                     /sec_met_domain="DAO (E-value: 1.3e-07, bitscore: 27.6,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFLDFTTGGPVADDKAPSGPVAERWDTRRFQARLVNPANRRKHR
                     IIVVGTGLAGGSAGATLAEQGYHVVQFCFQDSPRRAHSIAAQGGINAAKNYRNDGDSIH
                     RLFYDTVKGGDFRARESNVHRLAQISVEIIDQCVAQGVPFAREYGGLLDTRSFGGVQVS
                     RTFYARGQTGQQLLLGAYQALSRQIAAGNVEMHARTEMLDLVVVDGRARGIVARDLITG
                     EISTHYADAVVLASGGYGNVFYLSTNAMNSNATAVWRAHRRGAYFANPCFTQIHPTCIP
                     RTGDHQSKLTLMSESLRNDGRIWVPRAKGDTRAAADIPEDERDYYLERIYPSFGNLVPR
                     DIASRAAKNVCDEGRGVGPGGQGVYLDFADAIRRMGRAAVEEKYGNLFDMYARITAENP
                     YEVPMRIYPAVHYTMGGLWVDYDLQTTVPGLFAIGEANFSDHGANRLGASALMQGLADG
                     YFVLPATINDYLARHPHAEPVTDDHPAVREVLAETEDRLNLLLAVDGDRTPDSFHRELG
                     ELMWEYCGMARTEEGLRTALARIPEIREEFWSRIKVPGTGQEFNQSLEKANRIVDYLEL
                     AELMCLDALHRAESCGGHFREESQTPDGEAARHDEEFAYAAAWEFGGTGTAPVLHKEDL
                     TFEYVHPTQRSYA"
     gene            3959..4708
                     /locus_tag="AMK27_RS09505"
                     /old_locus_tag="AMK27_09325"
     CDS             3959..4708
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015038018.1"
                     /locus_tag="AMK27_RS09505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_09325"
                     /product="succinate dehydrogenase/fumarate reductase
                     iron-sulfur subunit"
                     /protein_id="WP_073904701.1"
                     /transl_table=11
                     /translation="MRLTLRVWRQRNADTPGAMSTYDVDGISADMSFLEMLDTLNEDLI
                     LRGEDPVAFDHDCREGICGACSLVINGDAHGPERTTTCQLHMRSFDDGDTIDVEPWRAS
                     AFPVVKDLVVDRSAFDRVIQAGGYISAPTGAAPEAHATPVPKADADFAFEHAECIGCGA
                     CVAACPNGSAMLFTSAKVNHLNVLPQGSPERETRVLDMVAQMDAEGFGGCTLTGECATA
                     CPKGIPLPSISAMNKEWLRAQRKAARG"
     gene            5001..5393
                     /locus_tag="AMK27_RS09510"
                     /old_locus_tag="AMK27_09330"
     CDS             5001..5393
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947258.1"
                     /locus_tag="AMK27_RS09510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_09330"
                     /product="tyrosinase cofactor"
                     /protein_id="WP_073904702.1"
                     /sec_met_domain="melC (E-value: 3.1e-47, bitscore: 156.4,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSITRRRVLGVAAGAAGAAAGLALAGSAVADGPRTAAPAAGPAP
                     ASFDEVYQGRRIKGGPAHGGGHHGGHHGGGYSVTIDGEELHVMQNADGTWISVINHYEP
                     VATPKSLARAAVRELQGAPLVPLTLG"
     gene            5416..6243
                     /locus_tag="AMK27_RS09515"
                     /old_locus_tag="AMK27_09335"
     CDS             5416..6243
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015038020.1"
                     /locus_tag="AMK27_RS09515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_09335"
                     /product="tyrosinase family protein"
                     /protein_id="WP_073904704.1"
                     /transl_table=11
                     /translation="MTVRKNQASLTADEKRRFVNAVLELKRSGRYDTFVTTHNAFIMSD
                     TDNGDRVGHRSPSFLPWHRRFLIEFEQALQSVDPTVNLPYWDWTADRTSRSSLWAPDFL
                     GGTGRARDGQVLDGAFARSGNRWTITVRVDGRDYLRRDLGAGGRQLPTRAEVDSVLAME
                     TYDTAPWNSSSDGFRNHLEGWRGVNLHNRVHVWVGGQMGTGVSPNDPVFWLHHAFIDKL
                     WADWQARHPRSPYLPAAGTANVVDLGDTMRPWNDVTPADMLDHTRHYTFDTAA"
     gene            complement(6329..8689)
                     /locus_tag="AMK27_RS09520"
                     /old_locus_tag="AMK27_09340"
     CDS             complement(6329..8689)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015038021.1"
                     /locus_tag="AMK27_RS09520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_09340"
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="WP_073904705.1"
                     /transl_table=11
                     /translation="MPESHHDPYVRVRGAREHNLAGVDVDIPRDALAVFTGVSGSGKSS
                     LAFGTIYAEAQRRYFESVAPYARRLIHQVGAPAVGEITGLPPAVSLEQRRSSPNARSSV
                     GTVTTLSNSLRMLFSRAGRYPEGAERLDSDAFSPNTAAGACPSCHGLGRVHDTSEELLV
                     PEPELSIRQGAIAAWPGAWQGKNLRDVLDTLGYDVDRPWRELDAKDREWILFTDEQPVV
                     TVHPVRDADRIQRPYQGTYMSARRYVLRTFSDSKSPTLRAKAERFLTSAPCPVCGGGRL
                     RPEALAVTFADRTIAELASLPLTALAGLLSAASAEDGETARVLTEDLVARIATVTELGL
                     GYLSLDRATPSLSNGELQRLRLATQLRSGLFGVVYVLDEPSAGLHPADTEALLVVLDRL
                     KAAGNSVFVVEHHLDVIRHADWLVDVGPLAGVHGGRVLHSGPPGGLADVEASATRRFLF
                     DREPRPAREVRAPAGWLRTGPVTRHNLRSVDAAFPVGVLTAVTGVSGSGKSTLVGALTE
                     ELSGVGRLVTVDQRPIGRTPRSNLATYTGLFDVVRKLFTETGEARARGYKAGRFSFNVP
                     GGRCETCQGEGFVSVELLFLPSTYAPCPDCHGARYNPETLQVRLRGLTIAEVLDLTVES
                     AAAFFEDTPAAARSLRTLLDVGLGYLRLGQPATELSGGEAQRIKLASELQRPHRSPTLY
                     VLDEPTTGLHPADVEVLMRQLHGLVDAGHSVIVVEHDMDVVATADWVLDLGPGGGDEGG
                     RIVAEGPPGRVARAAESRTAPYLLRALGPAARD"
     misc_feature    complement(8690..8708)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 18.64"
                     /tool="antismash"
     gene            8789..9916
                     /locus_tag="AMK27_RS09525"
                     /old_locus_tag="AMK27_09345"
     CDS             8789..9916
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007447982.1"
                     /locus_tag="AMK27_RS09525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_09345"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_073904707.1"
                     /transl_table=11
                     /translation="MDDRSRGAPGVPPGGTRTGGAGQLARTLPFLCLAAGVAFQVSTPR
                     ELTGTPLFAAAPLISAPLFAWWAAVLFGGAGLLAITVFYGVTGHMGGITALHGLVTELA
                     TLLCVTAIAVFLNRVVRRDRSRLASARGVAETAQRAVLPTPEHRLGALRSGARYEAAQE
                     HTLIGGDLYAARSTPHGVRLLIGDVRGKGLGAIETVSVILGAFWEAADREPSLHGVADS
                     LERALSREGSRRAGIDDTEGFATCAFVEIPPGDKELRVLNRGHPEPLLLRGDGTVVPLK
                     PRAFSLPLGLGELAPGPGEMTAGPFPPGATLLLYTDGLSEARNEAGVFYDPAVRLNGRT
                     FASPDRLLDALVADVHRFTGGARSDDMALLAVRRP"
ORIGIN
        1 acctgcgcgt ggcggcggcc ccgtccccgg ccggaccggt gggggagggg aggcggtggg
       61 tgtgccggac gaccagatgt tcgagagcgt ggaccatgcg ggcatgctcg cagccgccgc
      121 cggtccgtcg cacgcggatt tacgggggcg cgcgagggcc gacggggcgt gggcggcgcg
      181 acgccgactg cccgtggtca ggcggcgggg cggggcgtgc ggcgagcggc ggggcggggc
      241 gtgcggggag agagcggtgg cggttccgcc ggccgttccc tcagacggtg cccaccgtcc
      301 ggtccggtcc ggcccgtcgc gaggccagca gcatccgctg gagctcccgc gcggccctcg
      361 gcggtgcgac gtcgctgcgg tgggccaggg cgatggtccg gcgcaggccc ggccgggcca
      421 gggcggtcac ccggaggtcc cggcccgccc gcgccgccac catcgcgggg acgacagcga
      481 gcccgagccc ggcccgtacg aaaccgagga ccgcgtccag ctcgccgccc tcgaccgtga
      541 acgtcggctc gaagccctcc gcccggcagg ccgccacggt cagttcccgc aggtcgtagc
      601 cgtgccggaa catcacgagc ggctggtcgc gcaggtcggt gatccggacc gggcggcgcg
      661 gcgccggggc ggaggcggag gagacgacca ccaggtcctc ccggagcagc tccacggtcg
      721 tcagggccgg cgacgggctc ggcagcggca gcaccaccag cgccaggtcg agggcaccgc
      781 gggccagctc ccggacgagg tcgtgcgagc cgccctcctc gatgaggagc tcgattcccg
      841 ggtgcaggtc gtggaaggcg cgcaggacgt ccggcagcag ccccgtgcac aggctcgggg
      901 tcgccccgag ccgcacccgg ccccgcttca gctgggccag ctcctgcacc tcgatccggg
      961 cggtctcggt gtcggcgagg atccgccgcg cgagcggcag cagggcctcg cccgcgtcgg
     1021 tgagcgtgat gttcccgcgg gcccggctga acagctcggc gcccaactcc tgttccaggg
     1081 ccttgatctg ctgggagagc gagggctgcg agacatggac gcgctcggcg gcccgggtga
     1141 agtgacgggt ctcggccacg gcgacgaagt agaggagctg ctggaactgc atggtcacag
     1201 cgtaggcgac tttcataggg tgggcctatt gagatcagcc ggaccatgtc ttggacctct
     1261 cgggcccttc ggccctagcg tcgtaggcat ggctctggca cccacgaggg accggacgac
     1321 gggccgcccg ccgtccccca caccgtcacg cggattcctg tcgtcgaccc tcggcaagaa
     1381 gacggtcatg gcagtcagcg ggctgctcat gctcggctat ctcgtcgccc atgtcgccgg
     1441 caacctgaag gtcttcttcg gcccggagga gttcaacgcc tacggccact ggctgcgggt
     1501 catgggcgcc cccgtcctgc accacgagtg ggccctctgg ctcgtgcgga tcgtgctcct
     1561 cgccgccgtc gtggcccacg ccgtctccgc gtaccagctc agtcgccggg acgtgaaggc
     1621 ccgccccacc gcgtacgtcc accgccgcaa gcgctcctcg tacgccaccc gcaccatgcg
     1681 ctggggcggg atcatcctcg ccctcttcat cgtctggcac gtcctcgacc tgaccaccgg
     1741 gaccgtccac cccggcggct tcgaggaggg caagccctac cagaacgtcg tcgacacctt
     1801 ctccacctgg tacggcaacg tcatctacat cgtcgccatg ctcgccgtcg gcctccacgt
     1861 ccggcacggc ttctggagcg ccgcccagac cctcggcatc ggcagcgccc gccgcgagcg
     1921 cctcctgcgg ggcctcgccg acaccctcgc gctcgtcctg accgcgggct tcatctccgt
     1981 ccccgtcgcc gtcatgaccg gagtggtgag ctgacatgag cttcctcgac ttcacgaccg
     2041 gaggtccggt cgccgacgac aaggccccct cggggcccgt cgccgaacgc tgggacaccc
     2101 gccgcttcca ggccaggctg gtcaaccccg ccaaccgccg caagcaccgc atcatcgtgg
     2161 tcggcaccgg cctggccggc ggctccgccg gagccaccct cgccgaacag ggctaccacg
     2221 tcgtccagtt ctgcttccag gactccccgc gccgggccca ctccatcgcc gcccagggcg
     2281 gcatcaacgc cgcgaagaac taccgcaacg acggcgactc gatccaccgc ctcttctacg
     2341 acaccgtcaa gggcggcgac ttccgcgccc gcgagtccaa cgtccaccgg ctcgcccaga
     2401 tctccgtcga gatcatcgac cagtgcgtcg cccagggcgt ccccttcgcc cgcgagtacg
     2461 gcggactcct cgacacccgc tccttcggcg gcgtccaggt ctcccgcacc ttctacgccc
     2521 gcggccagac gggccagcag ctcctgctcg gcgcctacca ggcgctgtcc cggcagatcg
     2581 ccgccggaaa cgtcgagatg cacgcccgta cggagatgct cgacctggtc gtcgtcgacg
     2641 ggcgggcccg cgggatcgtc gcccgcgacc tgatcaccgg cgagatctcc acccactacg
     2701 cggacgcggt ggtcctcgcc agcggcggct acggcaacgt cttctacctg tcgacgaacg
     2761 ccatgaactc caacgccacc gccgtctggc gggcccaccg gcgcggcgcc tacttcgcca
     2821 acccctgctt cacccagatc caccccacct gcatcccgcg caccggcgac caccagtcca
     2881 agctgaccct gatgagcgag tcgctccgca acgacggccg catctgggtc ccccgggcca
     2941 agggcgacac ccgcgcggcg gccgacatcc ccgaggacga gcgcgactac tacctggagc
     3001 ggatctaccc ctccttcggc aacctcgtcc cgcgtgacat cgcctcccgc gccgcgaaga
     3061 acgtctgcga cgagggccgc ggcgtcggcc ccggcgggca gggcgtctac ctcgacttcg
     3121 ccgacgcgat ccgccgcatg ggccgggccg ccgtcgagga gaagtacggg aacctcttcg
     3181 acatgtacgc gcggatcacc gccgagaacc cgtacgaggt ccccatgcgg atctatcccg
     3241 ccgtccacta cacgatgggc ggactctggg tcgactacga cctccagacc accgtccccg
     3301 ggctcttcgc catcggcgag gcgaacttct ccgaccacgg cgccaaccgg ctcggcgcct
     3361 ccgccctcat gcagggcctc gccgacggct acttcgtcct cccggccacc atcaacgact
     3421 acctcgcccg gcacccccac gccgagcccg tcaccgacga ccacccggcc gtgcgggagg
     3481 tgctcgcgga gaccgaggac cggctgaacc tcctcctcgc cgtcgacggc gaccgcaccc
     3541 ccgactcctt ccaccgggaa ctcggcgaac tcatgtggga gtactgcggg atggcccgta
     3601 cggaggaggg cctgcggacc gcgctggccc ggatccccga gatccgcgag gagttctgga
     3661 gccggatcaa ggtccccggc accggccagg agttcaacca gtcgctcgag aaggccaacc
     3721 gcatcgtcga ctacctggag ctcgccgagc tcatgtgcct cgacgcgctg caccgcgccg
     3781 agtcctgcgg cggccacttc cgcgaggagt cccagacgcc ggacggcgaa gccgcccgcc
     3841 acgacgagga gttcgcgtac gcggcggcct gggagttcgg cggcacgggc acggcccccg
     3901 tcctccacaa ggaggacctc accttcgagt acgtccaccc cacccagcgg agctacgcat
     3961 gaggctcacc ctgcgcgtct ggcgccagcg gaacgccgac acccccggcg cgatgtccac
     4021 ctacgacgtg gacgggatct ccgccgacat gtcgttcctc gagatgctcg acaccctcaa
     4081 cgaggacctc atcctgcgcg gcgaggaccc cgtggccttc gaccacgact gccgcgaggg
     4141 gatctgcggc gcgtgcagcc tcgtcatcaa cggcgacgcg cacgggccgg agcggaccac
     4201 gacctgccag ctccacatgc ggtccttcga cgacggcgac acgatcgacg tcgagccctg
     4261 gcgggcctcc gccttcccgg tcgtcaagga cctggtcgtc gaccgctccg ccttcgaccg
     4321 ggtcatccag gccggcggct acatctccgc gcccacgggt gcggcccccg aggcccacgc
     4381 gacgcccgtc cccaaggccg acgcggactt cgccttcgag cacgccgagt gcatcggctg
     4441 cggcgcgtgt gtggcggcct gccccaacgg ctcggcgatg ctcttcacct ccgcgaaggt
     4501 caaccacctg aacgtgctgc cccagggctc cccggagcgc gagacccggg tcctcgacat
     4561 ggtcgcccag atggacgccg agggcttcgg cggctgcacg ttgacgggcg agtgcgcgac
     4621 ggcatgcccg aagggcatcc cgctgccgtc gatctccgcg atgaacaagg agtggctgcg
     4681 ggcgcagcgg aaggccgccc ggggctgagg ccggatcagg acagtctcgg ggcgtgggct
     4741 ccgccacacg acgcgccccg aatcgaaaga tcattcacga aacgaacact ttctccgtaa
     4801 gatcttcgct tcggggcgct gtcgaccgtg cgaacagcaa gatcaactcc gttcaattct
     4861 gtacatttca tggcaagttg tccacatcgc agccaacccg cctgcggcga tttccgcccc
     4921 gcccccaccc ccgggtactg atgagcactg ccgggggcat atgaccaaac ccccggtcgc
     4981 acagaccact tgggggtttc atgtccagca tcacccgccg ccgggtcctc ggcgtcgcgg
     5041 ccggagccgc aggggccgcc gcgggcctcg ccctggccgg atccgccgtc gccgacggtc
     5101 cccggaccgc ggcgccggca gccggtccgg ccccggcctc cttcgacgag gtctaccagg
     5161 gccgccgcat caagggcggg cccgcgcacg gcggaggcca ccacgggggg caccacggag
     5221 ggggctattc cgtgacgatc gacggcgagg aactgcacgt catgcagaac gccgacggca
     5281 cctggatcag cgtgatcaac cactacgagc ccgtcgccac gcccaagtcg ctggcccgcg
     5341 cggccgtccg cgaactccag ggcgccccgc tcgtacccct caccctcggc tgatcgatcc
     5401 aggaacggca acgtcatgac cgtacgcaag aaccaggcct ccctcaccgc cgacgagaag
     5461 cggcgcttcg tcaacgccgt cctggagctc aagcgctccg ggcggtacga caccttcgtc
     5521 accacgcaca acgccttcat catgagcgac accgacaacg gcgaccgcgt cggccaccgc
     5581 tcgccgtcgt tcctgccctg gcaccggcgc ttcctcatcg agttcgagca ggcgctccag
     5641 tccgtcgacc cgaccgtcaa cctcccctac tgggactgga cggccgaccg cacctcccgt
     5701 tcctcgctct gggcgcccga cttcctcggc ggcaccgggc gcgcccgcga cggccaggtg
     5761 ctcgacggcg cgttcgcccg cagcggcaac cgctggacga tcaccgtccg cgtcgacggc
     5821 cgcgactacc tgcggcgcga cctcggcgcg ggcggccgcc agctgcccac ccgggcagag
     5881 gtggactccg tcctcgccat ggagacctac gacacggctc cctggaacag ctcgtcggac
     5941 ggcttccgca accacctgga gggctggcgc ggcgtgaacc tccacaaccg cgtccacgtc
     6001 tgggtcggcg gccagatggg caccggggtc tccccgaacg accccgtctt ctggctgcac
     6061 cacgccttca tcgacaagct ctgggccgac tggcaggccc gtcacccccg gtccccgtac
     6121 ctgccggccg cgggcaccgc gaacgtcgtc gacctcggcg acaccatgcg cccgtggaac
     6181 gacgtgaccc cggccgacat gctcgaccac acccgccact acaccttcga cacggcggcc
     6241 tgacccaccg gacgggccgc cgctctccgg cggcccgacc cggtcccacg ggcttctgct
     6301 ccggcggccc cggcccgccg tgagggcctc agtccctcgc ggcgggaccg agggcgcgga
     6361 gcagatacgg cgcggtgcgg ctctccgccg cccgcgccac ccggcccggc gggccctcgg
     6421 ccacgatccg gccgccctcg tcgccgccgc ccggaccgag gtcgagcacc cagtccgcgg
     6481 tggcgaccac gtccatgtcg tgctcgacca cgatcaccga gtggccggcg tccaccaggc
     6541 cgtggagctg ccgcatcagg acctcgacgt ccgccgggtg cagacccgtc gtcggctcgt
     6601 caaggacgta cagcgtgggg gagcggtgcg gccgctggag ctcggacgcg agcttgatgc
     6661 gctgcgcctc gcccccggac agctccgtcg cgggctgccc cagccgcaga tagccgaggc
     6721 ccacgtcgag cagggtgcgc aggctccgcg cggcggcggg cgtgtcctcg aagaacgcgg
     6781 cggcggactc gacggtgaga tcgaggacct ccgcgatggt gagcccccgc agccgcacct
     6841 ggagcgtctc ggggttgtag cgggcgccgt ggcagtcggg gcagggcgcg tacgtactgg
     6901 gcaggaagag cagctccacg gagacgaagc cctcgccctg gcaggtctcg caccggcccc
     6961 cgggaacatt gaaggagaag cggccggcct tgtagccgcg ggcgcgcgcc tccccggtct
     7021 ccgtgaacag cttgcgcacc acgtcgaaca gacccgtgta cgtcgccagg ttggagcgcg
     7081 gggtgcgccc gatcggccgc tggtccaccg tcaccagacg ccccaccccg gagagttcct
     7141 cggtgagcgc gcccacgagc gtcgacttcc ccgagcccga tacgccggtg accgccgtca
     7201 gcaccccgac ggggaaggcc gcgtcgaccg accgcagatt gtgccgggtc accggccccg
     7261 tacgcagcca cccggccggc gcacgcacct cccgggcggg tcgcggctcc cggtcgaaga
     7321 ggaagcggcg cgtcgcggac gcctcgacgt ccgcgagtcc gcccggcggc ccgctgtgca
     7381 ggacccgccc gccgtgcact ccggcgagcg gcccgacgtc cacgagccag tcggcgtgcc
     7441 ggatcacgtc gaggtggtgc tcgacgacga agacggagtt cccggcggcc ttgagccggt
     7501 cgagcaccac gagcagggcc tcggtgtcgg ccgggtgcag acccgcggag ggctcgtcca
     7561 ggacgtacac cacgccgaag aggcccgagc gcagctgggt ggcgaggcgc agccgctgga
     7621 gctcgccgtt ggagaggctg ggggtggccc ggtccaggct gagatagccg aggccgagct
     7681 cggtcacggt cgcgatccgg gcgacgaggt cctcggtcag gacgcgcgcg gtctccccgt
     7741 cctccgccga cgcggcggag aggagcccgg ccagcgccgt cagcggaagc gacgccagct
     7801 cggcgatggt ccggtcggcg aacgtcaccg cgagcgcctc gggccgcagc cgcccgccgc
     7861 cgcagaccgg gcagggcgcg ctggtgagga accgctcggc cttcgcccgc agcgtggggc
     7921 tcttcgagtc ggagaaggtc cgcaggacgt agcgccgcgc actcatgtac gtgccctggt
     7981 acgggcgttg gatgcggtcc gcgtcccgta ccggatggac cgtgacgacc ggctgctcgt
     8041 ccgtgaacag gatccactcc cggtccttcg cgtcgagctc gcgccacggc cggtcgacgt
     8101 cgtacccgag ggtgtcgagg acgtcccgta ggttcttccc ctgccaggcg cccggccagg
     8161 ccgcgatcgc cccctgacgg atcgacagct cgggctcggg aacgaggagt tcctcgctcg
     8221 tgtcgtggac gcggccgagc ccgtggcacg aagggcaggc gcccgcggcc gtgttggggg
     8281 agaaggcgtc ggagtcgagc cgctcggccc cctccggata gcggcccgcc cgggagaaca
     8341 gcatgcggag ggagttggag agggtggtga ccgtgccgac ggaggagcgg gcgttcgggg
     8401 aggaccggcg ctgctccagg gagaccgccg gcgggagccc ggtgatctca ccgacggcag
     8461 gcgcccccac ctggtggatc agccgccgcg cgtacggcgc caccgactcg aagtagcgtc
     8521 gctgggcctc cgcgtagatc gtaccgaagg ccagggagga cttgccggat ccggagaccc
     8581 cggtgaagac ggcgagcgcg tcgcggggga tgtcgacgtc cactcccgcg aggttgtgct
     8641 cacgggcacc gcggacacgg acgtacggat catggtggct ttcgggcata cggtgatttt
     8701 atccggcgaa ccgggaggtc cctcactcgc aggggggtcg gggcgcccgc atactgggag
     8761 ggggccggct gcctccctgg agggccgcat ggacgatcgt tcacgtggtg ccccgggcgt
     8821 gccgcccggg ggaacccgca ccggcggcgc cgggcaactc gcccggaccc tgccctttct
     8881 gtgcctggcg gcgggggtgg ccttccaggt cagcaccccg agagaactga ccggaacccc
     8941 tctcttcgcc gcggctccgc tgatctccgc gccgctcttc gcctggtggg ccgcggttct
     9001 gttcggcggc gcgggactgc tggccatcac ggtcttctac ggggtcaccg ggcacatggg
     9061 cggcatcacc gccctccacg gtctcgtgac cgaactggcg accctgctct gcgtcacggc
     9121 gatcgccgtc ttcctcaacc gcgtggtgcg ccgcgacagg agccgcctgg cctccgcccg
     9181 gggcgtcgcc gagaccgcgc agcgggccgt gctgccgacg cccgagcacc gactcggagc
     9241 gctgaggtcc ggtgcccgtt acgaggccgc ccaggagcac accctcatcg gcggggacct
     9301 ctacgccgcc cgctccaccc cgcacggggt gcgcctcctc atcggcgacg tccggggcaa
     9361 ggggctgggg gccatcgaga cggtctccgt gatcctcggc gccttctggg aggccgcgga
     9421 ccgggaaccg tccctgcacg gcgtggcgga cagcctggaa cgcgccctga gccgcgaggg
     9481 aagccgccgc gcgggcatcg acgacacgga gggcttcgcc acctgcgcct tcgtggagat
     9541 cccgcccggg gacaaggaac tgcgcgtgct gaaccggggg catcccgagc cgctgctgct
     9601 ccgcggcgac gggaccgtcg tcccgttgaa gccccgggcc ttctccctcc cgctggggct
     9661 cggggaactc gccccggggc cgggtgagat gacggcgggc ccgttcccgc cgggggccac
     9721 cctgctgctc tacacggacg gactgtcgga ggcccggaac gaggcgggcg tcttctacga
     9781 tccggccgtc cggctgaatg gccggacctt cgcctcgccg gaccgcctcc tcgacgcgct
     9841 cgtcgccgac gtccaccggt tcaccggcgg cgcgcggtcc gacgacatgg cactgcttgc
     9901 cgtccgccgc ccctgagact gcctacgtga gcccctaccg ccctcgcgag cctgcggtac
     9961 gactcgctca gccgcccctg agacggccta cgtgaggccc accgccctcg cgagtctccg
    10021 gtacgactcg ctcagcgccg ccctgtcgta cgtgctcgtg gtgaccagga cctcctgcgc
    10081 cccggtctcc ttcactgccc tctccagcgc gtcggccacc tgctcctccg tgccgtgcac
    10141 atggccggtc aggcccgact cgtagaaacc gcgctgcttc tccgtcatca cgagcccctc
    10201 gaccgcctcg ggcgcgacga gcggcgggaa gacgcccagc gtccgggagt gggcgagcga
    10261 ccaggcctcc ggcatcagca gccgcctggc ctccgcctcc gtccccgcca ccgcgaccgt
    10321 cccggcgatc accacgtacg gctcggcgga ccacacggag gggcggaacg cggagcggta
    10381 cgtctccacg gcg
//
