LOCUS       NZ_LIVV01000002        22646 bp    DNA     linear   CON 28-MAR-2024
DEFINITION  Streptomyces sp. CB02009 scaffold2, whole genome shotgun sequence.
ACCESSION   NZ_LIVV01000002
VERSION     NZ_LIVV01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CB02009
  ORGANISM  Streptomyces sp. CB02009
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 1350328)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1350328)
  AUTHORS   Yan,X., Ge,H., Hindra,F., Yang,D., Huang,T., Crnovcic,I. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-AUG-2015) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC Genomics Workbench v. 7.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905825.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:41:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,214
            CDSs (total)                      :: 8,139
            Genes (coding)                    :: 7,984
            CDSs (with protein)               :: 7,984
            Genes (RNA)                       :: 75
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 51 of 155
            Pseudo Genes (incomplete)         :: 117 of 155
            Pseudo Genes (internal stop)      :: 15 of 155
            Pseudo Genes (multiple problems)  :: 26 of 155
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:06:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 282579
            Orig. end                         :: 305225
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LIVV01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22646
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="4"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22646
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22646
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12646](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12646)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    1828..1842
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     tRNA            1976..2049
                     /anticodon=(pos:284589..284591,aa:Pro,seq:ggg)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="AMK27_RS08675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="AMK27_08505"
                     /product="tRNA-Pro"
     gene            1976..2049
                     /locus_tag="AMK27_RS08675"
                     /old_locus_tag="AMK27_08505"
     gene            complement(2170..4746)
                     /locus_tag="AMK27_RS08680"
                     /old_locus_tag="AMK27_08510"
     CDS             complement(2170..4746)
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020551468.1"
                     /locus_tag="AMK27_RS08680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_08510"
                     /product="SpoIIE family protein phosphatase/ATP-binding
                     protein"
                     /protein_id="WP_107425513.1"
                     /transl_table=11
                     /translation="MAIVVLLAAGALLALLLQSRYDIDREARNRSVSVAQTFANSLGLQ
                     EALRSPDPSAILQPLTEKTRKDAGVDFLVVMDTNGIRYTHPQPDLIGKQFVGTIEPSLA
                     GEVYTESVEGPLGKEIQATVPVTSPGGQVVALVSAGLTVASVTGVADRQLPVILLAIAI
                     GLALATVGTALISRRLRRQTHGLGTQEMTRMYEHHDAVLHSVREGVVITDGDGRLLLAN
                     DEAGRLLGLPDDAEGRPVDEVGMDRRMAELLLSGRVATDEVLEAGDRLLVVNQRPTLPR
                     GSAVTIRDSTEMQLLSSRAETARKRLKLLYDAGGDIGTTLDVVRTAKELADVAVPQFAD
                     FVTVDLADAVLHGDEPGPGADMRRTAVSGIRPDHPLYPLGALIDFLPSTPQARGYGTGT
                     TELVPDLHDAPGWHAQDPQRTSQIVDYGIHSLIAAPLKARGVVLGIVNFWRSQKPEPFD
                     EDDLSLAEELVGRAAVTMDNARRYTREHHLAVTLQRSLLPRDLPEQSAVDVAHFYQPAQ
                     SGVGGDWFDVIPLSGSRVGLVVGDVVGHGLHAAATMGRLRTAVHNFSSLDLPPDELLAR
                     LDNLVQRMDQEGDGTPSDGGVMGATCLYAVYDPVSQNCAMARAGHVPPLVVAPDGTTTI
                     SELPAGPPLGLGGMPFETMEVHLAEGSQLVLYTDGLVEERSRDISEGLETLRTALSHPD
                     RDPEASRRAVLDALLPARPADDIALLIARTRTLGPGRVAEWDVPFDPSEVGTVRALAAG
                     KLDEWGLEELAFTTELILSELITNAIRYAAAPVRVRLLCDRNLTCEVWDGSSTAPHLQY
                     ATTTDEGGRGLFLVAQLSEHWGTRYTPEGKVIWAEQALPAEGGAFS"
     misc_feature    complement(4781..4795)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.98"
                     /tool="antismash"
     gene            5302..5916
                     /locus_tag="AMK27_RS08685"
                     /old_locus_tag="AMK27_08515"
     CDS             5302..5916
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037659.1"
                     /locus_tag="AMK27_RS08685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_08515"
                     /product="response regulator transcription factor"
                     /protein_id="WP_073904459.1"
                     /transl_table=11
                     /translation="MIRVTVVYEAQLLRTALVELLRSGGIMVGSSLDRWPHGPAAGVSE
                     PDVYVADAGCLPASAVRPVAAAAPASGEGPGVRPALLALVPGQRPGVLRRAHAAGATGF
                     VDQNAPKCRLLEAVHRLAKGERYIDDTLALGFLQAAEMPLTRRELSVLSLAADGAPVAE
                     IAATLFLTKGTVRNYMASVIRKVGARNRVDAIRIAQGAGWT"
     misc_feature    5641..5643
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(5952..7811)
                     /locus_tag="AMK27_RS08690"
                     /old_locus_tag="AMK27_08520"
     CDS             complement(5952..7811)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037660.1"
                     /locus_tag="AMK27_RS08690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_08520"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_079188304.1"
                     /transl_table=11
                     /translation="MRPAPSPERAKEPITPSATDRPAPSAAPGEADSARRVTAFLRSLL
                     LLRRSVLLKLAAWSAAESAQTFLGGYCVARALDDGFLRGAPSTGLLWLAGAAVAILLGA
                     PVIRGVFAQLPHLTEPLRDQLVQGSVVRALRTATATATGGGGGGGGSGDATAVSRLTSQ
                     TEIARDSFAGLVLATRSFVFVAVGALVGLLSLAPQFLLVVLPPLVLGLALFTASLRPMA
                     RAQHRYLDADEAVGRRAGITRSALRDTVACGAQEATAAQNRRAVEEAAAAQRALARWAS
                     VRTFSVATAGQLPVLLLLATAPWLLRQGVTAGAVVGALTYVLQSLLPALHTLMTVLGAA
                     GARLFVVLDRLTQPPPPVPTPSPTPDPAADSPGPRRTGRAAAALELRHVRAAYGPGARP
                     VLDALELTVEQGEHIAVVGPSGIGKSTLLHIAAGMLTPDHGDVRLFGRDVAACPPSELP
                     ALRVLIPQEAYVFTGTLRDNLRYLRPDADRAAVDRTVDALALAPLVDRVGGLDRTLTPD
                     ALSLGERQRIALGRAHLAPAPLLLLDEATCHLDPVAEATAERALSARPGTLVVVAHRLS
                     SALRADRILVLDGTLARYGTHDELLARSALYRDLVGHWSRVRE"
     gene            complement(7808..9679)
                     /locus_tag="AMK27_RS08695"
                     /old_locus_tag="AMK27_08525"
     CDS             complement(7808..9679)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037661.1"
                     /locus_tag="AMK27_RS08695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_08525"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_073904461.1"
                     /transl_table=11
                     /translation="MASPTGSDRLLRGAVRHTAGTTAALLLCSVAGAACSLAVPAVAGR
                     TLDLLLRDRPGAGTWLLWTAVLLAAEVLLETGSVLLTQLTNARATAWIRLRALGGLLGT
                     APHRAAPHSGGDVAARLCVNATDSGTAPAALATSVSSVLVPVGALVALALIHPWTAAVF
                     VAGLPLLLLLLRAFATQSSDSVGHYQRAQGAVAARLAEALGGARTIAAAGTARHEEERV
                     LAPLPEMARHGTRMWLVHGRAVARSGVLLPLLTTAVVAVAGVGLAAGEVSVGGLLAASR
                     YAALAAGIGGIAAPLGTLVRARSAARRTAELADLAPMPHGSAVLPADAPGNLELRGVRV
                     TRGGVPLLTDVTLAIGGGSTVAVVGRSGAGKSTLAAVAGRLTDPDAGSVRLDGVDLAAL
                     SRSELRGATSYAFARPVFDGGATPTVGAALAAGTGPGRSPATPTSVRDAATAACADTFV
                     RLLPLGYETPVDDAPLSGGEAQRLGLARAFIGRGRLMILDDATSSLDTATERQVETALA
                     TPARACTRLIVAHRVSTAARADLVVWLEGGRVRRSGPHSLLWEEPEYRAVFSAEAAQTT
                     QTTQTTEATHDTGATQATPAPPADAPPATAGSGALRSSAVPGTGADE"
     gene            complement(9828..9956)
                     /locus_tag="AMK27_RS08700"
                     /old_locus_tag="AMK27_08530"
     CDS             complement(9828..9956)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018849360.1"
                     /locus_tag="AMK27_RS08700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_08530"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_015037662.1"
                     /transl_table=11
                     /translation="MNLFDLQSLETPKDEAIGDVETGSRASLLLCGDSSLSVTTCN"
     CDS_motif       complement(9894..9956)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MNLFDLQSLETPKDEAIGDVE"
                     /locus_tag="AMK27_RS08700_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9828..9893)
                     /prepeptide="core"
                     /locus_tag="AMK27_RS08700_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="22.80"
                     /molecular_weight="1941.2"
                     /monoisotopic_mass="1940.0"
                     /core_sequence="TGSRASLLLCGDSSLSVTTCN"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNLFDLQSLETPKDEAIGDVE"
                     /leader_location="[9893:9956](-)"
                     /alternative_weights="1959.2"
                     /alternative_weights="1977.2"
                     /alternative_weights="1995.2"
                     /alternative_weights="2013.2"
                     /alternative_weights="2031.3"
                     /alternative_weights="2049.3"
     misc_feature    complement(9948..9963)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.85"
                     /tool="antismash"
     gene            complement(10001..12646)
                     /gene="lanKC"
                     /locus_tag="AMK27_RS08705"
                     /old_locus_tag="AMK27_08535"
     CDS             complement(10001..12646)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037663.1"
                     /locus_tag="AMK27_RS08705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_08535"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_073904463.1"
                     /sec_met_domain="micKC (E-value: 5.8e-238, bitscore: 788.1,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 6.9e-11, bitscore: 38.1,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 4.8e-05, bitscore:
                     18.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKGYAVFCDADRHFYDAPHRLVFAEGAGDSLYRAATLPVPEGWT
                     SHRTGDWLALRPLDHALPSQGWKIHVSACLDNAEAILATVRAYCLEQDVAFKFVPSRYL
                     LHQRNAKYADRSASGKFITVYPADDQQCERVATDLAGLLEGRPGPYILSDLRWGRGPVH
                     LRYGSFTVRHCYDEHGELRPAVEDGSGTLVPDRRDPVFHVPAWVTPPAFLTPHLEARAS
                     VTVQDMPYAVEKALHFSNGGGVYEARDRRTGRRVVLKEARPYAGLAADGADAVTRLHRE
                     REALERLSGLACTPEVLDSFTVGDHHFLALEFVEGKPLNTFFARRHPLMEADPPAERLA
                     EYTEWALRMHGLVERAVAAVHARGIVFNDLHLFNIMVSEDESSVVLLDFEAAQPAAEGG
                     RQTVANPGFVAPADRRGFDVDRYALACLRIALFIPLTSLLAVDRGKAAHLAETAAARFP
                     LPPGFLDEAVREITRDPAGGPAGGSTRAADRPADRAPFLPAEPGDWPNSRDSMVAAILA
                     SATPEREDRFFPGDIAQFATSGGGMTVGHGTAGVLHALHESGAPRCPEAEDRLLRHAKQ
                     PDSGTPLGFYDGLAGVAWTLERLGHPAAALELASLVAEQDHEGLAPDLYGGTAGLGLAL
                     DALATATGESGLHAAALRCAELSARPLRSPGRPAGAAGAAAPAGKARTGLLYGSAGRAL
                     LFIRLYERTRDTALLDLAAEALHDDLSRCVRGASGTLQVDEGWRTMPYLGAGSVGIGMV
                     IDDYLLHRRDDALDRARREIVQAAQATFYAQPGLFRGVAGMVLHLARTNVGGPGTTPGD
                     VRRQVGCLSWHAMSYQGRLAFPGEQMMRLSMDLSTGTAGVLLALSSALGDRPAHLPFLP
                     PLPRPHEPAP"
     misc_feature    12671..12686
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.28"
                     /tool="antismash"
     misc_feature    12674..12686
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.11"
                     /tool="antismash"
     misc_feature    complement(12734..12751)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.45"
                     /tool="antismash"
     gene            complement(12868..13707)
                     /locus_tag="AMK27_RS08710"
                     /old_locus_tag="AMK27_08540"
     CDS             complement(12868..13707)
                     /EC_number="1.1.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (4-161). E-value: 1.2e-10. Score:
                     33.6. Matches aSDomain:
                     nrpspksdomains_AMK27_RS08710_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008740754.1"
                     /locus_tag="AMK27_RS08710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_08540"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_073904465.1"
                     /sec_met_domain="adh_short (E-value: 7e-31, bitscore:
                     103.7, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGRRWLITGCSSGLGRALAAAAAGAGHELVVTARKTADLEDLAAA
                     WPGRIVPVPLELRDPTSCEEAVRTAVDRLGGIDVLVNNAGVGLFGAVEEVSDAELREQL
                     EILLVGPWRLARLALPLMRAQGHGHILNVSSIVGRMAFPGLGAYVAAKHALEGMSEALA
                     VEAAPHGIRVTVVEPGMFATRYGTAMTEAAHRVPAYDVTNREMLEGARGLADSPETGRP
                     DDYAARVLAIVHAEGPTPLRIPVGADAYGYLDVAEQAAREEYAAARALVDGPPPQTV"
     aSDomain        complement(13225..13695)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMK27_RS08710_PKS_KR.1"
                     /evalue="1.20E-10"
                     /label="AMK27_RS08710_PKS_KR.1"
                     /locus_tag="AMK27_RS08710"
                     /protein_end="161"
                     /protein_start="4"
                     /score="33.6"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="WLITGCSSGLGRALAAAAAGAGHELVVTARKTADLEDLAAAWPGR
                     IVPVPLELRDPTSCEEAVRTAVDRLGGIDVLVNNAGVGLFGAVEEVSDAELREQLEILL
                     VGPWRLARLALPLMRAQGHGHILNVSSIVGRMAFPGLGAYVAAKHALEGMSEA"
     CDS_motif       complement(13627..13692)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMK27_RS08710_0001"
                     /evalue="8.80E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="AMK27_RS08710"
                     /protein_end="27"
                     /protein_start="5"
                     /score="12.0"
                     /tool="antismash"
                     /translation="LITGCSSGLGRALAAAAAGAGH"
     misc_feature    14024..14039
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.11"
                     /tool="antismash"
     misc_feature    14102..14111
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            14223..15398
                     /locus_tag="AMK27_RS08715"
                     /old_locus_tag="AMK27_08545"
     CDS             14223..15398
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017240743.1"
                     /locus_tag="AMK27_RS08715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_08545"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_073904467.1"
                     /sec_met_domain="Pkinase (E-value: 9.3e-45, bitscore:
                     149.1, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQVRPWRVQPDSRLTAHAVAGRYRLDGLLGRGGAADVYEAVDLRL
                     RRPVAVKVFRRGDARTEEHSDGEGRLLAQLQHPGLVTLFDSGHDEGRPFLVMELVRGTT
                     LRRRLARSALSVTETCRMGAALSSALAHVHGTGIVHRDVKPSNILLDPTGAPRLTDFGI
                     SRRFAATDDPAAAPHEAASGTDAPATDGEGILTGTASYMAPEQALGRTTGPRADIYSLG
                     LVLLEALKGEREYDGTPLEAALARLHRPPALPAGLPPDLGELLKAMTAHTPSSRPDART
                     CETALAALPTPDARDPGAETAPGGPPHPSGVHRSPGTPPSARTRPTRTRSLHGPGRLLA
                     KSAALAALGVTLTGSIGAAPVGSRSTADPLSHRVTSEQIPDGAGHVGDRRR"
     gene            15905..17623
                     /locus_tag="AMK27_RS08720"
                     /old_locus_tag="AMK27_08550"
     CDS             15905..17623
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037816.4"
                     /locus_tag="AMK27_RS08720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_08550"
                     /product="RNase A-like domain-containing protein"
                     /protein_id="WP_073904468.1"
                     /transl_table=11
                     /translation="MSNPWTGPGGFDVQPLHLYQVSAALSVEQQSFHKALVQFLDVHAG
                     YSKVGGSGTATAEFATQYAAVVALLMEAHGKAVVAIGGAAVGFTTTANNFRQADAATHP
                     LSPSFVPQAPPQVISAPPAYPAPPPFGVRDGNAVDEFADIFDGGDIPGSLMRTVIEEAL
                     RTGRALEILPLPNYLRVNQLSQAWLPYQTGVGIIQGQLTATIDVITDHANGDWHGAMLQ
                     FVSSVWGTTAWGKNTAGYEWGHKPPTGAGTSLPVFGVLSTTAQILAQAVRTYAEAAEKV
                     RTELREILHKAIKDALALLEVTDFRDFIGNFVERLKKLWKGLGAAVLLSIDTDAVNAAV
                     DTYETTLRAQTQKVKGLLEPLQEASRAVPTFQSESARAEAFGARSLFEFDRSIVPLNEQ
                     SRDPNVRFGIDLASVEWERNDFQPPPPEGLRGGKEAHTIDKHIGLTPEQLMHRLRDQGG
                     ADASTFRDLRSAEQYVQTGVNDPAKKTELETWMRNQERKVADGTFRPGSVKAWDFPVTD
                     ANGNPVAVGTSVSQSDFAASGFSARPKDVHTVHVVLAYSPESKSFYVLTAYPKAP"
     gene            17634..18293
                     /locus_tag="AMK27_RS08725"
                     /old_locus_tag="AMK27_08555"
     CDS             17634..18293
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK27_RS08725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AMK27_08555"
                     /product="hypothetical protein"
                     /protein_id="WP_143204835.1"
                     /transl_table=11
                     /translation="MTEPTDAVLTSGVLARLVDLAAASRNPGAAPLEDELQRFARLMQD
                     SHTIAWVMPFDAVASLLEALADECGTERFAARPTVFRDRLARAAGDEQADTFLRTLAAL
                     LRDPWFGDCPGYDELPLSQWEALARFDIVNEFASQLPTGEYGSDPEAEALDLVAMDHPD
                     CHGRIADLAGQLQRVLYMFRSSAELDAAFAPVMPSVTTARLRLLLDAVHAHFTEQH"
     gene            18328..18738
                     /locus_tag="AMK27_RS08730"
                     /old_locus_tag="AMK27_08560"
     CDS             18328..18738
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019888038.1"
                     /locus_tag="AMK27_RS08730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_08560"
                     /product="WXG100 family type VII secretion target"
                     /protein_id="WP_073904472.1"
                     /transl_table=11
                     /translation="MPVDPNLAVADEDLKRLADDLDAMRTYIDGQVRRMDAIVDRAEAR
                     WRSEAATAYRKLHREAGADAVRVREILGVLAQAVRMSRDGFTRQELDTLRQFRAEMKKV
                     DVDAEVRELSGERPADAAPGGDPAPVSRISEL"
     misc_feature    complement(18369..18389)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.62"
                     /tool="antismash"
     gene            18764..19066
                     /locus_tag="AMK27_RS08735"
                     /old_locus_tag="AMK27_08565"
     CDS             18764..19066
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007450954.1"
                     /locus_tag="AMK27_RS08735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_08565"
                     /product="WXG100 family type VII secretion target"
                     /protein_id="WP_073904474.1"
                     /transl_table=11
                     /translation="MSEDGSIHVDLVALREIGGDLEDIVKTLNERLTALYDRTVPVVLA
                     WQGEAREAFVDELDRWDRQMEDLQAAQKWLHAVVANGHANYSAAQRATLRGWGGA"
     gene            19068..19409
                     /locus_tag="AMK27_RS08740"
                     /old_locus_tag="AMK27_08570"
     CDS             19068..19409
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015611354.1"
                     /locus_tag="AMK27_RS08740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_08570"
                     /product="RNase A-like domain-containing protein"
                     /protein_id="WP_073904476.1"
                     /transl_table=11
                     /translation="MTTPPAARVPARADRAATFPDRATAQWATQQVITLNEQVIHRWLA
                     QSTRQRLVIEAAWPSRPDPVGTLLTTGMALAGQDPIPVRAARVVLRRTGSGGPGGPPFT
                     VHSSLPVDL"
     gene            19418..20056
                     /locus_tag="AMK27_RS08745"
                     /old_locus_tag="AMK27_08575"
     CDS             19418..20056
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020128592.1"
                     /locus_tag="AMK27_RS08745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_08575"
                     /product="contact-dependent growth inhibition system
                     immunity protein"
                     /protein_id="WP_073904478.1"
                     /transl_table=11
                     /translation="MSLNPAEHDRKYGELDQVVRAHLGLGPHAPEAVGGYLRQTWRTRP
                     WAIAVAAEQLRVYADNPPGRLRIRLGEYYRLPDVGLPPEEIRDWLTGVADRLDGSLVNG
                     EAPPPAAPATPWEWRARFPELAQLLGGWFSQDMPDEFGDHEAALADYLAGTDGGLVAQL
                     TGELYDLLALGLDEDGLALALVTLGAEVEPPVPFGPGAWLAVLAVRLRA"
     gene            complement(20058..21005)
                     /locus_tag="AMK27_RS08750"
                     /old_locus_tag="AMK27_08580"
     CDS             complement(20058..21005)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK27_RS08750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AMK27_08580"
                     /product="glycoside hydrolase family 16 protein"
                     /protein_id="WP_073904480.1"
                     /transl_table=11
                     /translation="MSQPRRTSRRRAWTALTLPALLCVLAACSAAPATGGADAAGPARE
                     ASPTPTGPPGTLFDDFDYTGADDPSLAAHGWEVRTGGGGPGIKDTWSADGAAFPSDQTA
                     EAGKVLRLRSSTDGTAQGTTQTEVQTTGGNFFTGTYAARVHLSDRPTSGRDGDHVVQTF
                     FPISSSDSSENYSELDFEYLPNGGWGSVGPQLDNVSWYKADPPDRVHNTVKRSLAGWHT
                     MVITAMDGKVTYSLDGKELFTSSGKYVAREQMDIHFSNWLIDLPFTGGPRVWDMKVDWV
                     YHKADEAVSPAEIRTTVDDFQSAGTAYVNTVATP"
     gene            21358..21594
                     /locus_tag="AMK27_RS08755"
                     /old_locus_tag="AMK27_08585"
     CDS             21358..21594
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK27_RS08755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AMK27_08585"
                     /product="hypothetical protein"
                     /protein_id="WP_143204836.1"
                     /transl_table=11
                     /translation="MAESHQFAPAPIPVFVDQSGLRSRQLRRLGWPVSVVGAMLAAAMG
                     SSLIGVQSDAPAMGIPPKPSYQPTKGPLSPSWP"
ORIGIN
        1 ccgtggcagg atccgtcgcc ctgctccgcg agctggggac gggcgcgcgc ggcgggggcc
       61 tcgtcgcccg cctccaggcg ctcggcgccg gaccgacgcg cctggcgagg gcgatcgccg
      121 tgctcggccc ggacagcacg ccgcgactcc tgagggcgct cacggggatg gcgggaaccg
      181 agctggcggc gcacacggac cgcctccgcc gggcgaggat cgtgacggcg cccgatacgc
      241 cggcgacacc ggccccctcc gcacacgccg acgccacacc cacgaccgcc acgccgtcgg
      301 cgcctcccgc cccggcgggt ccgctggaat tcacgcatcc gctgatcgcg acggccgtgt
      361 acggatcggt gcccgcagcg acacggtccg ccctgcacgg gcgcgccgca cgggcgctgg
      421 ccgaggcggg acacggtccg gccgccgccg cccggcacct cctcgacgtc cagccggcgg
      481 acgacgagga cgccgtccgc ctgctgcggg ccggcgccgc cgagcacctg gccgtcggag
      541 cccccgacgc ggcccgccgc tgcctggacc gggccctcgc cgagccgccg ggccccgaga
      601 cgtacgccgt cgtcctctac gagctcggct gcgcgtcgct gctcaccgcg ccggccgcga
      661 ccgtccggca cctccgctcg gcgctcgacc tgcccggcct ggacgacacg ctccgcgtcg
      721 acgccaccta ccggctcgcc caggtcctcg cccacagcaa ccagctcggg gaggcggcgc
      781 ggaccgtcga ggccgaggcg gtccgcaccc cgcccggcac cggccgacgg cgcctccagg
      841 ccgcgcactt catgtacgag gggttccagg ccgcggagga ggacggcccg ggccgctcgc
      901 gtcgcctcgc cgagctcacc gggcgcctca ccggggcgga caacccggaa cgcgccctgc
      961 tcgccgtccg cgccttcgac gcgatgctca ggggcgaacc ggcggccgag gtcgtacgac
     1021 tctgcgacag cgccctcgtc gacggcgcac cggccagggg gctcggctgg accgacacca
     1081 cctggggttt cgagatcccg gcgctcaccg gcatcgcgta cgcgttcgcc gaccggcccg
     1141 accgggcgcg ggccctgttc ggcgaggcgg tgcgggcctt cgagatctcc ggctggaacg
     1201 gcgcccacct ggccttcgcc cacaccctcc tgggcctggc ccaccgcagg cgcggagacc
     1261 tgcccagggc gcagcaccac ctggaggagg gactccgcct ggcggaccgg gtgggccgcg
     1321 ggctccccgt ccactgggac acggcctgcc tcctggtcga cacgctgctc gcccggggcc
     1381 gtaccgccga ggccagggag gtcgccgacc gctacgcctt cggcccgccc tggccgggag
     1441 cgatcgtgct gcccgacggc ccgagcgtcc tcggccgcct cctgctggcc gagggccggc
     1501 acgaggaggc ggcccacacc ctggaggcgg cggccgaggc gctgaccgcc cgcggccgcc
     1561 accacgtgct ctgggcaccc tggcccttcg acctcgcgcg ggccctcgcg acgacggacc
     1621 cggaccgcgc ggcccgcgtc gccaccgagg cccgcgccca cgcggaacgc ctcggcaccc
     1681 ccaccgcccg cggcgaagcc ctccgctgcc tggccctctt cgccaccccc gccgagtccc
     1741 gccgcctcct cacccgcgcc gtcgcgcacc tggcggagtc cccctcccgc tacgaggagt
     1801 cccgagcccg cctggacctc gcccacgcga cgggctcggc caccgccctc gccgaggcaa
     1861 cggccctggc caccacctgc ggcgcggtga cagcccgtgc gtcaacccac cctccggagt
     1921 gaggtagtgt tttccctgca cgccgacgcg ggggaaaccc cacgaggacg agcaccggga
     1981 cgtggcgcag cttggtagcg cacttgactg ggggtcaagg ggtcgcaggt tcaaatcctg
     2041 tcgtcccgac tcgaaagagt cgcaggtcag aggtcgtttc agagcaatct gaagcggcct
     2101 ctgacccgtt tccggggact acgtggggcc caactcgtgt cgaccgcgcc ggcgggcgac
     2161 gaccgaggtc taggagaagg caccgccctc cgcgggcagg gcctgttcgg cccagatcac
     2221 cttgccttcc ggggtgtacc gggtgcccca gtgctcgctg agctgggcca ccaggaacag
     2281 tccgcggcct ccctcgtccg tggtggtggc gtactgcaga tgcggggcgg tgctgctgcc
     2341 gtcccacacc tcgcaggtca gattgcgatc gcacagcaga cgcacgcgca cgggcgcggc
     2401 ggcgtacctg atggcgttcg tgatgagctc gctgaggatc agttccgtgg tgaaggcgag
     2461 ctcctccagg ccccactcat cgagtttccc ggccgcgagg gcgcgcacgg tgccgacctc
     2521 gctcgggtcg aacggtacgt cccactcggc gactcggccg gggcccagag tccgtgtccg
     2581 ggcgatgagc agcgcgatgt cgtcggccgg ccgggcgggg agcagggcgt cgagcacggc
     2641 gcggcggctg gcctccgggt cccggtcggg gtggctcagc gcggtgcgca gcgtctccag
     2701 gccctccgag atgtcccggc tccgctcctc gaccagcccg tcggtgtaca ggacgagctg
     2761 actgccttcc gccaggtgca cttccatggt ctcgaacggc atgcctccca gccccagcgg
     2821 agggccggcc ggcagttccg agatcgtcgt cgtgccgtcc ggggcgacca cgagcggtgg
     2881 cacgtgtcct gcccgcgcca tggcgcagtt ctgggagacc gggtcgtaga cggcgtacag
     2941 gcaggtcgca cccatgacac cgccgtccga gggcgtgccg tcgccttcct ggtccatgcg
     3001 ctggacgagg ttgtcgagac gggcgaggag ttcgtcgggc ggcaggtcca gggaggagaa
     3061 gttgtgcacg gccgtgcgca gccgccccat ggtggccgcg gcgtgcaggc cgtgcccgac
     3121 gacgtctccg acgacgagcc cgacgcggct gcccgacagc gggatcacgt cgaaccagtc
     3181 cccgcccact ccggactgcg cgggctggta gaagtgcgcg acgtccaccg cgctctgctc
     3241 gggcaggtcc cgcggcagca ggctgcgctg gagcgtcacg gccagatggt gctcgcgggt
     3301 gtagcggcgg gcgttgtcca tggtgaccgc ggcgcggccg acgagctcct cggccaggga
     3361 caggtcgtcc tcgtcgaacg gctccggctt ctgcgaccgc cagaagttga cgatcccgag
     3421 cacgacaccc ctggccttca gcggcgccgc gatgagcgag tggatgccgt agtcgacgat
     3481 ctgggacgtc cgctgcgggt cctgggcgtg ccagcccggc gcgtcatgga gatcgggtac
     3541 gagctccgtc gtgcccgtac cgtagccacg ggcctgcggt gtggacggca ggaagtcgat
     3601 cagtgcgccg agcgggtaca gcgggtgatc gggtcggatg ccgctgaccg ccgtgcgccg
     3661 catgtcggcg cccgggccgg gctcgtcgcc gtgcagtacc gcgtcggcca gatcgaccgt
     3721 gacgaagtcc gcgaactggg gaacggcgac gtcggccagc tccttcgcgg tgcggaccac
     3781 gtcgagggtc gtcccgatgt caccccccgc gtcgtacagc agcttgagcc gcttgcgggc
     3841 cgtctccgcc cgactgctca ggagctgcat ctcggtggag tcgcggatgg tgaccgccga
     3901 gccccgcggg agcgtgggcc gctgattgac cacgagcagc cggtccccgg cctccagcac
     3961 ctcgtccgtg gccacccggc cggacagcag cagttccgcc atgcgacggt ccatcccgac
     4021 ctcgtcgacg gggcgccctt cggcgtcgtc cggcaggccg agcagccgtc ccgcctcgtc
     4081 gttcgccagg agcagccgtc cgtcgccgtc cgtgatcacc accccttcgc ggacggagtg
     4141 gagcaccgcg tcgtggtgct cgtacatgcg ggtcatctcc tgcgtgccga gcccgtgggt
     4201 ctggcgccga agtcttcggc tgatcagcgc cgtgccgacg gtggccaggg ccagaccgat
     4261 ggcgatggcc aggaggatga ccgggagctg acggtcggcg acgccggtca cgctcgccac
     4321 cgtcagacca gccgagacca gggcgacgac ctgacccccg ggcgaggtga ccgggacggt
     4381 cgcctggatc tccttgccga gcggcccctc gacactctcg gtgtacacct cgccggccag
     4441 tgagggctcg atcgtcccga cgaactgctt gccgatgagg tcgggctgcg ggtgggtgta
     4501 gcggatgccg ttcgtgtcca tcaccacgag gaagtccacg cccgcgtcct tccgcgtctt
     4561 ctcggtgagg ggctgcagga tcgcggacgg gtccggcgac ctcagcgctt cctgcaggcc
     4621 cagggagttc gcgaaggtct gtgccacgga cacggaccgg ttgcgcgcct cacggtcgat
     4681 gtcgtaccgc gactgcagca gcagggccag cagggcaccg gcggcgagca gcaccacgat
     4741 cgccacctga aggacgaaga cctgtccggc gacgcttccg aatcttctgc ctagtttcga
     4801 ccgcaccggt acgccgggca cgagagacga gacgggctca caaccccagt tgtagcacct
     4861 ccccgcggcc agggcccgag atgttcacgg tacgcgtccg gaccaccgca cccggttccc
     4921 gtcgcggccg gaccccgggc agcggcgcac gggaggtgcg gtccggcgcc gcggccgaac
     4981 cccggcggcg gcgggtgcgg tccggccggg cccctggggg gcggcgcacg ggcggtgccg
     5041 ccgggcccct gggggcgcac ttccgccgtc gcgcgcccgt atgggtccga tctggacatt
     5101 cctggttcgg cgcggccggc agcgcaggcc gtcggcctgc ttcgccttcg aagggacgca
     5161 ccggatccgg ccggggcgct ccggagtgcg cccccttgtg cacccggtgc tgtgttccgc
     5221 ctgatgcggc aagggcagag gggtgggggt ggctgctcgc gtcgtgcacc tctggcacgg
     5281 cggaggaccg aaggggtggg aatgatacga gtgacggtgg tctacgaggc gcagctcctg
     5341 cggaccgcgc tggtcgaact gctgaggtcg ggcgggatca tggtgggctc ctcgctcgac
     5401 cgatggccgc acggcccggc ggcgggggtg tccgagcccg acgtgtacgt ggcggacgcc
     5461 gggtgtctgc ctgcctcggc ggtgcggccc gtggccgctg ccgcaccggc ctcgggggag
     5521 gggccgggtg tccggcccgc gctgctggcc ctcgtccccg ggcagcggcc gggggtgctg
     5581 cgccgggccc atgccgcggg ggcgaccggc ttcgtcgacc agaacgcccc gaagtgtcga
     5641 ttattggagg ccgtgcaccg tctggccaag ggggagcgct acatcgacga cacgctcgcg
     5701 ctcgggttcc tccaggcggc ggagatgccg ctgacccggc gcgagctgag cgtcctctcg
     5761 ctggccgccg acggagcgcc ggtcgccgag atcgccgcga cgctgttcct gaccaagggc
     5821 accgtccgca actacatggc gagcgtcatc cgcaaggtcg gcgcacggaa ccgcgtggac
     5881 gccatccgga tcgcccaggg cgccgggtgg acctagagca ccgccgcggc gtcctcgccg
     5941 tcacggtccg ctcactcgcg gacccggctc cagtgcccta ccagatcgcg gtagagagcg
     6001 gaacgcgcga gcagctcgtc gtgcgttccg taccgggcca gggtgccgtc gaggacgagg
     6061 atccggtcgg ccctgagagc ggacgacaac cggtgggcga ccacgaccag ggtccccggc
     6121 cgcgcgctca gggcccgctc ggccgtggcc tccgcgacgg ggtccaggtg gcaggtcgcc
     6181 tcgtcgagca ggagcagcgg ggcgggggcc agatgggcgc gccccagcgc gatccgctgg
     6241 cgttcgccga gggacagggc gtcgggcgtc agcgtacggt cgagcccgcc cacccggtcg
     6301 acgagcggtg ccagggcgag cgcgtccacg gtccggtcga cggcggcccg gtcggcatcg
     6361 ggccgcaggt accgcaggtt gtcccgcagg gtgcccgtga agacgtacgc ctcctggggg
     6421 atcagcacgc gcagggcggg gagctcggag ggcgggcagg ccgcgacgtc gcggccgaag
     6481 agccgtacgt cgccgtgatc gggggtgagc atgcccgccg cgatgtgcag cagggtcgac
     6541 ttgccgatgc cgctcgggcc gaccacggcg atgtgttccc cctgctcgac ggtcagttcc
     6601 agcgcgtcca gcacggggcg tgccccgggt ccgtacgcgg cgcggacgtg gcgcagctcc
     6661 agggccgcgg cggcgcggcc ggtacggcgc gggccggggg agtcggcggc ggggtcgggg
     6721 gtcggggaag gggtcgggac agggggcggc ggctgcgtga gccggtcgag gacgacgaag
     6781 agccgcgcgc ccgcggcgcc caggacggtc atcagggtgt gcagcgcggg gagcagcgac
     6841 tggaggacgt aggtgagcgc acccaccacg gctccggccg tgacgccctg gcgcagaagc
     6901 cacggcgccg tggcgagcag caggaggacc ggcagctgtc cggccgtcgc caccgagaac
     6961 gtgcggacgg acgcccagcg ggccagggcg cgctgggcgg cggccgcctc ctcgacggcg
     7021 cggcggttct gcgcggcggt cgcctcctgg gcgccgcagg ccacggtgtc ccgcagcgcg
     7081 ctgcgggtga tcccggcgcg ccggccgacg gcctcgtccg cgtcgaggta ccggtgctgg
     7141 gcccgcgcca tgggccgcag ggaggccgtg aacagggcga ggcccagcac caggggcgga
     7201 agcacgacga ggaggaactg cggcgcgagc gacagcagac cgacgagggc ccccacggcg
     7261 acgaagacga aggaacgggt ggcgagcacc agtccggcga agctgtcccg ggcgatctcg
     7321 gtctgactcg tcagccggga caccgcggtg gcgtccccgc tgccgcctcc gcctccgcct
     7381 ccgcctgtgg cggtggccgt ggcggtgcgc agggcgcgta cgaccgaccc ttgtacgagc
     7441 tggtcgcgca gcggttccgt gaggtggggg agctgggcga agacgcctcg gatgacggga
     7501 gcgccgagca ggatggccac ggcggccccc gcgagccaga ggagcccggt cgagggcgcg
     7561 cccctcagga atccgtcgtc gagggcgcgg gccacgcagt agccgccgag gaacgtctgc
     7621 gcggattcgg cggccgacca ggccgccagc ttcagcagga cgcttctgcg gaggaggagc
     7681 agagaacgga ggaaggctgt gacgcgccgg gccgagtccg cctcgccggg ggcggcggac
     7741 ggtgccgggc ggtccgtcgc actcggcgtg atcggttcct tcgccctctc cgggctcgga
     7801 gccggcctca ctcgtccgct cccgtccccg ggacggccga cgaccgcagt gcgccggagc
     7861 cggcggtcgc cgggggagcg tccgcgggcg gggccggcgt ggcctgcgta gcccctgtgt
     7921 cgtgtgtggc ttccgtggtc tgcgtggtct gcgtggtctg cgcggcctcc gcgctgaaca
     7981 ccgcgcggta ctccggctcc tcccagagca ggctgtgggg tccggacctg cgtacgcggc
     8041 ccccctccag ccagacgacc aggtccgccc gggcggccgt ggacacccgg tgggcgacga
     8101 tcagcctggt gcacgcccgt gccggagtgg ccagggcggt ctccacctgg cgttcggtgg
     8161 ccgtgtcgag gctcgacgtg gcgtcgtcga ggatcatcag acggccccgg ccgatgaacg
     8221 cccgtgccag acccaggcgt tgggcctcgc cgccggagag cggggcgtcg tccaccgggg
     8281 tctcgtagcc cagcggcagc agtcggacga aggtgtcggc gcaggcggcc gtcgccgcgt
     8341 cccggacgct cgtcggtgtc gcagggctcc ggccgggccc ggtcccggcg gccagcgcgg
     8401 cgccgaccgt gggcgtggcc ccgccgtcga agacgggacg cgcgaaggcg tacgaggtcg
     8461 ccccgcgcag ttcagagcgg gacagtgccg ccaggtcgac cccgtccagg cggacgctcc
     8521 cggcgtcggg gtcggtcagc cggcccgcga cggcggccag cgtcgacttg cccgctccgg
     8581 agcggcccac gacggcgacc gtcgatccgc cgccgatcgc gagcgtcacg tccgtgagga
     8641 gcgggacgcc gccgcgcgtc acccgcacgc cccgcagttc caggttcccg ggcgcgtcgg
     8701 ccggcaggac tgcggagccg tgcggcatcg gcgccagatc ggcgagttcg gcggtgcggc
     8761 gtgccgcgct gcgggctcgg accagggtgc cgagcggcgc cgcgatgccg ccgatcccgg
     8821 cggcgagcgc cgcgtaccgg gaggcggcga gcagaccgcc cacgctgacc tcgcccgcgg
     8881 cgaggccgac tcccgcgacc gcgacgacgg ccgtggtgag cagcggcagg aggacgccgc
     8941 tgcgggccac ggcgcggccg tggacgagcc acatgcgggt gccgtgccgt gccatctccg
     9001 gcagcggggc gaggacgcgc tcctcctcgt gccgtgccgt gccggcggcg gcgatggtcc
     9061 gggcgccgcc cagcgcttcg gccagccggg cggcgacggc gccctgcgcc cgctggtagt
     9121 ggccgaccga gtcggaggac tgggtggcga acgcgcggag cagcagcagg agcaggggca
     9181 gaccggccac gaagacggcg gcggtccagg gatggatgag cgccagggcg acgagtgcgc
     9241 cgaccggcac gagcacggac gacaccgagg tcgcgagggc cgccggggcg gtgccgctgt
     9301 cggtggcgtt gacgcacagc cgggcggcga cgtcgccgcc cgagtggggt gccgcccggt
     9361 ggggagcggt gccgaggagc ccgcccaggg cgcgcagccg gatccaggcg gtggcgcggg
     9421 cgttcgtcag ctgcgtcaga aggacggagc cggtctccag gagcacctcg gcggcgagca
     9481 ggacggcggt ccacagcagc cacgtccccg ccccgggccg gtcacggagc agcaggtcca
     9541 gggtcctgcc ggcgaccgcg ggtacggcga gcgagcaggc cgcgccggcg accgagcaga
     9601 gcagcagcgc cgcggtggtg cccgccgtgt gccgtacggc gccgcggagc agccggtcgg
     9661 aaccggtcgg cgaggccatc cggcctcctc tcttcccctc cggaagcgat gtcgccgccg
     9721 ggcccgccgg tgtccggccc cgacggccgg agccccggga gcagcgctcc cggggccccg
     9781 tgactcctca ccggcgctcg ggacgccgtg cgggaagccg gatcgggtca gttacaggtg
     9841 gtgacgctga ggctgctgtc accgcagagc aggaggctcg cgcggctccc ggtctcgacg
     9901 tcgccgatgg cctcgtcctt gggggtctcc agagactgaa ggtcgaagag gttcatgatc
     9961 gtttcctttc gtaggggacg ggtggtgcgg ggcgaccccg tcagggggcc ggttcgtggg
    10021 gccgcggaag cggcggaagg aacggcaggt gggccgggcg gtcgcccagg gccgaggaga
    10081 gcgcgagcag gacgcccgcc gtaccggtgg agaggtccat ggagaggcgc atcatctgct
    10141 cgccggggaa ggcgagtcgg ccctggtagg acatggcgtg ccagctcagg caaccgacct
    10201 ggcggcgtac gtcccccggt gtcgtgccgg ggccgccgac gttcgtacgg gcgaggtgga
    10261 gcaccatccc cgcgacgccc cggaagagcc cgggctgcgc gtagaaggtg gcctgcgccg
    10321 cctgtacgat ctcgcggcgc gcccggtcca gggcgtcgtc gcgccggtgg agcaggtagt
    10381 cgtcgatcac catgccgatg cccacgctgc ccgcgccgag gtacggcatc gtgcgccagc
    10441 cctcgtcgac ctgcagggtc ccggaggcgc cgcggacgca acggctcagg tcgtcgtgga
    10501 gcgcctcggc ggcgaggtcg aggagggcgg tgtcccgggt gcgctcgtag aggcgtatga
    10561 acagcagggc ccgtccggcg gagccgtaca ggagtcccgt acgcgccttg cctgccggtg
    10621 ccgccgctcc cgccgctcct gccggtcgcc cgggcgaccg gagcgggcgg gcggacagct
    10681 cggcgcagcg cagggccgcc gcgtggaggc cgctctcgcc ggtggcggtg gccagggcgt
    10741 ccagggcgag gccgagaccg gccgtccctc cgtacaggtc gggggcgagg ccctcgtggt
    10801 cctgttcggc gacgagtgag gccagttcga gcgcggcggc cgggtgcccg agccgttcga
    10861 gggtccacgc gacaccggcg agaccgtcgt agaagccgag cggtgtgccg gagtcgggtt
    10921 gcttggcgtg ccgcaggagc ctgtcctcgg cctcgggaca tcggggtgcc ccgctctcgt
    10981 gcagggcgtg gagcactccg gccgtgccgt gaccgacggt catgcctccg ccggaggtgg
    11041 cgaactgggc gatgtccccg gggaagaaac gatcctccct ctcaggtgtc gccgacgcga
    11101 ggatcgcggc caccatggag tcacgactgt tcggccagtc acccggctcc gcgggcagga
    11161 acggggcgcg gtccgccgga cggtcggccg cccgcgtgct cccgcctgcc gggccgccgg
    11221 ccgggtcgcg cgtgatctcc cgaaccgcct cgtccaggaa gccgggaggt agcgggaacc
    11281 gcgccgcggc ggtctccgcg aggtgcgcgg ccttgccccg gtccaccgcg agcagactcg
    11341 tgagcgggat gaacagcgcg atccggaggc acgcgagggc gtaccggtcc acatcgaagc
    11401 cccgccggtc ggcgggcgcc acgaaccccg ggttggcgac ggtctggcga ccgccctcgg
    11461 cggcgggttg ggccgcctcg aagtccagca ggaccaccga ggactcgtcc tcggacacca
    11521 tgatgttgaa cagatgcagg tcgttgaaga cgatcccgcg tgcgtgcacc gcggccacgg
    11581 cccgctcgac gagcccgtgc atccgcagcg cccactccgt gtactcggcg agccgctccg
    11641 ccggcggatc ggcctccatc agcggatgcc tccgcgcgaa gaaggtgttg agcggcttgc
    11701 cctccacgaa ctccagcgcc aggaagtggt ggtcgcccac ggtgaagctg tcgaggacct
    11761 ccggcgtgca ggcgagcccc gagagccgtt ccagcgcctc gcgttcgcgg tgcagccgcg
    11821 tcacggcgtc cgcgccgtcg gcggcgaggc cggcgtacgg ccgcgcctcc ttcagcacga
    11881 cccgccgccc ggtccgccgg tcccgggcct cgtacacccc accgccgttg gagaagtgca
    11941 gggccttctc gacggcgtac ggcatgtcct ggacggtcac cgaggccctc gcctccaggt
    12001 gcggagtcag gaaggcgggg ggagtcaccc aggcgggcac atggaagacg ggatcgcgcc
    12061 ggtcgggcac gagcgtgccg gacccgtcct cgacggccgg ccgcagctcc ccgtgctcgt
    12121 cgtagcagtg gcggacggtg aagctgccgt accgcaggtg cacggggccg cggccccagc
    12181 gcagatcgct gaggatgtac ggacccggcc ggccctccag cagccccgcc agatcggtgg
    12241 ccacgcgctc gcactgctgg tcgtcggccg ggtacacggt gatgaacttg ccgctcgccg
    12301 agcggtccgc gtacttggcg ttgcgctggt gcagcaggta gcggctgggg acgaacttga
    12361 aggccacgtc ctgttccaga cagtacgcac ggacggtggc gaggatcgcc tccgcgttgt
    12421 cgagacaggc ggagacgtgg atcttccatc cctgcgacgg gagcgcgtgg tccagggggc
    12481 gcagggcgag ccagtcgccc gtacggtggg acgtccagcc ctcgggtacg gggagggtgg
    12541 ccgcccggta cagggagtca cccgcaccct cggcgaagac caggcggtgc ggcgcgtcgt
    12601 agaagtgacg gtcggcgtcg cagaacaccg cgtacccctt gttcactgcg cactccctcg
    12661 gtcggtgacg gacacgacgc tgtcacgtcc ccggagggcc ccgacagtcg ccgctgtcac
    12721 cttccggcta tgcggaacgc acaggtaaca acagccccgc gggcggctcg ggttcgcacg
    12781 accggcccgc gctcgcaccc gacacggccg gccgtatcgg gtgcgagcgc ggagtccgcg
    12841 cggcccggga agcggtacga cggtccgtca gaccgtttga ggtggcggcc cgtcgaccag
    12901 cgcccgggcc gcggcgtact cctcgcgggc ggcctgttcc gcgacgtcga gatagccgta
    12961 cgcgtcggcg ccgaccggga tgcgcagggg cgtggggccc tcggcgtgga cgatggccag
    13021 gacccgtgcc gcgtagtcgt cggggcgtcc ggtctcgggg ctgtcggcga gtccgcgcgc
    13081 gccttcgagc atctcgcggt tggtcacgtc gtaggccggg acccggtggg cggcttccgt
    13141 catggcggtg ccgtagcggg tggcgaacat gccgggttcg acgaccgtga cacggatgcc
    13201 gtgcggggcc gcctccaccg cgagcgcctc gctcatgcct tccagggcgt gcttcgcggc
    13261 cacgtaggcg ccgaggccgg ggaaggccat ccggccgacg atggacgaga cgttgaggat
    13321 gtggccgtgc ccctgggccc gcatcagggg cagcgcgagc cgtgcgagtc tccagggccc
    13381 gacgagcagg atctccaact gctcccggag ttcggcgtcg gagacctcct cgaccgcgcc
    13441 gaagagaccg acgccggcgt tgttgacgag gacatcgatg cccccgaggc ggtcgacggc
    13501 cgtccggacg gcctcctcgc aggaggtcgg gtcccgcagc tccagcggaa ccgggacgat
    13561 ccgccccggc caggcggccg cgagatcctc caggtccgcg gtcttgcggg cggtgacgac
    13621 gagttcgtgc cccgcccctg ccgccgcggc ggccaaggcc cttccgaggc ccgaagaaca
    13681 ccccgtgatc aaccagcgtc tgcccatgga tccccccgta cggatcgccg aagtgatgac
    13741 gcgcgaacgg tcctgccctc tcgcgccgcc ggacgcgcac cgtcccgtcc gcgcgggacg
    13801 ggacgcgctt catcgtgaag gcgagatccg gccacgacca tccctcacgc aggggcgcgc
    13861 ggacgcacgg tcgggcgcat cggcgcccgc tcaccgagcc ctccgacccg gcgaaccacc
    13921 gcgtcgggga atcgagttcg ggcctacccc tcgaggagcg tccggaggtc ctcccgcccg
    13981 cccgagacgc gaccggccgc ccgcgtccgt cgaacgcgcg gatgtcacag ggatgtcccg
    14041 gggcatccgg ggcagccgta ccccgaggtc cgcacgcggc ggctgtacgg ccgcgatgtt
    14101 cgaaggcggc ccccgccccg ggccgacggg tccgcaccgg gcggggggcg aagagcggca
    14161 ccccgctcgc cgacgaagag ccggacggca gaaggcggca acggaagaca gggagcaccg
    14221 agatgcaggt ccgtccgtgg cgcgtccaac ccgactcccg gctgaccgcc cacgcggtcg
    14281 ccggccggta ccggctcgac ggcctgctgg gcagaggggg cgcggccgac gtctacgaag
    14341 ccgtggacct ccggctgcgc aggcccgtcg cggtgaaggt cttccgccgc ggcgacgccc
    14401 ggaccgagga gcactccgac ggcgaggggc gtctcctggc ccagctgcag catcccggtc
    14461 tcgtgacgct cttcgactcc ggtcacgacg aaggccgccc cttcctggtg atggagctcg
    14521 tcagggggac gaccctgcgc cggcgcctgg cccgctccgc gctgtcggtg accgagacct
    14581 gccgcatggg ggccgcgctg tcctccgcgc tcgcccacgt gcacggaacg ggaatagtgc
    14641 accgcgacgt caagccgtcg aacatcctcc tggacccgac cggggccccg cgcctgacgg
    14701 acttcgggat ctcccgccgc ttcgccgcca ccgacgaccc cgcggccgcg ccccacgaag
    14761 ccgcgagcgg cacggacgcc ccggccaccg acggcgaggg catcctcacg gggacggcct
    14821 cctacatggc gccggaacag gcactgggcc ggaccaccgg gccgcgggcc gacatctaca
    14881 gcctcggact cgtcctcctg gaggccctca agggcgagcg ggagtacgac ggaacgcccc
    14941 tggaggcggc actcgcacgg ctgcaccgcc cgccggcgct gcccgccgga cttcccccgg
    15001 acctcggcga actgttgaag gccatgacgg cgcacacgcc ttccagccgc cccgacgccc
    15061 gcacctgcga gacggcactg gccgcgctgc cgacacccga cgcgcgcgat cccggggcgg
    15121 agacggcgcc cggcggccct ccgcacccgt cgggagtcca ccgctcgccc ggtacgcccc
    15181 cgagcgcgcg gacccggccc acgaggacca ggtcgctcca cggcccgggg cgactgctcg
    15241 ccaagagcgc ggccctggcc gccctgggcg tcaccctgac gggctccatc ggcgccgccc
    15301 cggtcgggag ccgaagcacc gcggacccgc tgtcccaccg cgtgacctcc gagcagatac
    15361 cggacggggc ggggcacgtg ggcgaccgga ggcgatgacg gccgaccgac ccggacccgg
    15421 gccgtgggaa gcggcgcgtt ccgagaccac gcgacgacgg ggcacaaggc cgagtgcttc
    15481 gacggcggca tcgccacgat ggccaaggac tcgggtcttt cggccaactc cagtcgcgat
    15541 catgagatgt gacgcctcgt cctgctagct tcggcagcag tctgacgggg tcggggggac
    15601 tcatgggacg gggagaagaa cagggcaggg gtgcgtgcgc gtgctcccgc gcggcgtgcg
    15661 gaacggtcag gaatcaccgg tgagtacgcc gagcccgagc ccgagtccga ccggtacggc
    15721 accaccgagt cccggcccgc agcccaccac gacaccggca cccggcacga cgcatctgcc
    15781 gtcgccgggg ccgtcgccga gcacgccagg acctcagccg acgccgtcgc cgagcccgaa
    15841 cgcgccgccg acgccgcccg tgtccggccc gccgccccag ctgcctccgg cgacgccgcc
    15901 cgccgtgagc aacccgtgga cgggccccgg cggcttcgac gtccagccac tccacctgta
    15961 ccaggtgtcc gcggccctct ccgtcgagca gcagtcgttc cacaaggcgc tcgtgcagtt
    16021 cctcgacgtg cacgcgggct actccaaggt gggcggatcc ggcaccgcca cagccgagtt
    16081 cgccacccag tacgccgcgg tcgtcgccct gctcatggag gcgcacggaa aggccgtggt
    16141 cgccatcggc ggcgcggcgg tcggtttcac caccacggcc aacaacttcc ggcaggcgga
    16201 cgccgcgacc caccccctca gcccgtcctt cgtaccgcag gccccgccgc aggtcatctc
    16261 cgcgccgccg gcctacccgg ctccaccgcc gttcggcgtc cgcgacggca acgccgtcga
    16321 cgagttcgcc gacatcttcg acggcggcga cattcccggc tccctgatgc gcaccgtgat
    16381 cgaggaggcg ctgcgtaccg gccgagcact ggagatactg ccgctcccga actacctcag
    16441 ggtcaaccag ctgtcgcagg catggctgcc gtaccagacg ggcgtcggca tcatccaggg
    16501 gcagctcacc gccaccatcg acgtcatcac ggaccatgcc aacggggact ggcacggggc
    16561 gatgctgcag ttcgtgtcgt cggtgtgggg cacgacggcc tggggcaaga atacggccgg
    16621 ctacgagtgg gggcacaagc cgccgaccgg tgcgggcacg agcctcccgg tcttcggcgt
    16681 cctcagcacc acggcccaga tcctggccca ggccgttcgc acgtacgcgg aggccgcgga
    16741 gaaggtccgc accgaactgc gcgagatcct gcacaaggcg atcaaggacg ccctggccct
    16801 tctggaggtc accgatttca gggacttcat cgggaacttc gtcgagcgcc tcaagaagct
    16861 gtggaagggc ctcggcgccg cggtgctcct cagcatcgac acggacgccg tcaacgcggc
    16921 cgtcgacacc tacgagacca cgctgcgggc ccagacgcag aaggtgaaag gcctgctcga
    16981 accgctgcag gaggcttcgc gcgcggtgcc gaccttccaa tcggagtcgg cgagggcgga
    17041 ggcgttcggg gcgcgctcgc tcttcgagtt cgaccggtcg atcgtcccgc tcaacgagca
    17101 gtcgcgggac ccgaacgtca ggttcggcat cgacctcgcg tccgtggaat gggagcgcaa
    17161 cgacttccag cccccacccc ccgagggcct gaggggcggc aaggaagccc acacgatcga
    17221 caagcacatc gggctcaccc ccgagcagct gatgcaccga ctgcgcgacc agggcggcgc
    17281 cgacgcgtcg acgttccgcg atctgcggtc cgccgagcag tacgtgcaga ccggggtcaa
    17341 cgaccccgcg aagaagaccg agctggagac ctggatgcgc aaccaggagc ggaaggtggc
    17401 cgacggtacg ttcagaccgg gatccgtcaa ggcctgggac ttcccggtca cggacgcgaa
    17461 cggcaatccg gtggccgtgg gaacctccgt gagtcagtcg gacttcgccg cgtcgggctt
    17521 ctcggcccgg cccaaggacg tgcacacggt gcacgtggtc ctcgcctact cgcccgagtc
    17581 gaagtccttc tacgtgctca ccgcctatcc gaaggcccct tagcatgcgt caggtgaccg
    17641 aaccgaccga cgccgtcctc accagcgggg tgctcgcccg cctcgtcgac ctcgccgcgg
    17701 cctcgcgcaa cccgggggcc gcccccttgg aggatgaact ccagcgtttc gcccgcctga
    17761 tgcaggactc gcacacgatc gcctgggtca tgcccttcga cgcggtggcc tcgctcctcg
    17821 aggcactggc ggacgaatgc ggcacggagc ggttcgcggc gaggccgacg gtgttccgtg
    17881 atcggctcgc tcgggcggcc ggcgacgaac aagccgacac cttccttcgt acgctcgcgg
    17941 cgctcctccg ggacccgtgg ttcggcgact gcccgggcta tgacgaactg ccgctctcgc
    18001 agtgggaggc actcgcccgt ttcgacatcg tcaacgagtt cgcgtcacag ctgcccaccg
    18061 gtgagtacgg cagcgacccc gaggcggaag cactcgacct ggtcgccatg gatcacccgg
    18121 actgccacgg cagaatcgcc gatctcgcgg gacaactcca acgagtcctc tacatgttcc
    18181 gctcgtctgc cgagctcgac gcggccttcg cgcccgtcat gccgtcggtg acgaccgcgc
    18241 ggctgcggct gctgctcgac gccgtccacg cccacttcac cgagcagcac tgacccacca
    18301 ctccatcgcc ccgaaaggag ccgccgcatg cccgtcgatc cgaacctcgc cgtcgcggac
    18361 gaggacctga agcgtctcgc cgacgatctg gacgccatgc ggacgtacat cgacgggcag
    18421 gtgcgccgga tggacgcgat cgtcgaccgg gccgaggcgc ggtggcgcag cgaggcggcg
    18481 acggcgtacc ggaagctgca ccgcgaggcc ggggcggacg ccgttcgggt gcgggagatc
    18541 ctgggagtgc tggcgcaggc ggtccggatg agccgggacg ggttcacccg ccaggagctg
    18601 gacaccctgc ggcagttccg ggccgagatg aagaaggtcg acgtcgacgc ggaggtacgg
    18661 gaactgtcgg gagagaggcc ggccgacgcg gctcccggtg gtgatccggc accggtcagc
    18721 cggatcagtg agctctgaac atccgtaccg cagaggggga aacatgagtg aggacggctc
    18781 gatccacgtc gacctggtcg cgctgcgcga gataggcggc gatctcgagg acatcgtgaa
    18841 gacgctcaac gagcgcctga ccgcgctcta cgaccgcacg gtgccggtcg tcctggcctg
    18901 gcagggcgag gctcgcgagg ccttcgtgga cgaactcgac cgctgggacc ggcagatgga
    18961 ggacctgcag gccgcgcaga agtggctgca cgccgtggtc gccaacgggc acgccaacta
    19021 ctccgccgcc cagcgggcca ccctgcgcgg ctggggcggg gcctgacatg acgacccctc
    19081 ccgcggcccg cgtcccggcc cgcgccgatc gcgccgccac cttcccggac cgggcgaccg
    19141 cccagtgggc cacccagcag gtgatcacgc tgaacgagca ggtcatccac cgctggctcg
    19201 cccagtccac gcggcagcgg ctcgtgatcg aggccgcctg gccctcgcgg cccgatccgg
    19261 tgggcacgct gctcaccacg gggatggcgc tcgccggcca ggatccgatc ccggtgcgcg
    19321 ctgccagggt ggtgctccgc aggaccggat ccggtggtcc gggcgggccc cccttcaccg
    19381 tgcactcctc cctgcccgtc gacctgtaga ggccaccgtg tccctgaacc ccgccgagca
    19441 cgaccgcaag tacggcgagc tcgaccaggt cgtccgcgcc cacctcggcc tcggcccgca
    19501 cgctcccgag gcggtgggcg gctatctgcg gcagacgtgg cgcacccggc cctgggcgat
    19561 cgccgtcgcg gcggagcagc tgcgcgtgta cgccgacaat ccgccgggac ggctgcggat
    19621 acggctcggc gagtactacc ggctgcccga cgtggggctg ccccccgagg agatccggga
    19681 ctggctcacg ggcgtcgccg accggctcga cggaagcctg gtgaacggag aggcgccacc
    19741 gccggccgcg ccggcgacgc cctgggagtg gcgggcgcgc ttccccgagc tggcgcagct
    19801 gctcggcgga tggttctcgc aggacatgcc ggacgagttc ggcgaccacg aggccgcgct
    19861 cgccgactat ctggcgggca cggacggggg gctcgtcgcc cagctcacgg gggagttgta
    19921 cgacctcctc gccctgggcc tcgacgagga cggcctggcc ctcgcgctgg tgacgctcgg
    19981 cgcggaggtc gagcccccgg tgccgttcgg ccccggtgcc tggctcgccg tgctcgccgt
    20041 gcggctgcgg gcctgaatca gggcgtcgcg acggtgttga cgtaggccgt gccggcgctc
    20101 tggaagtcgt ccaccgtcgt ccggatctcc gccggggaga cggcctcgtc ggccttgtgg
    20161 tagacccagt cgaccttcat gtcccagacg cgcgggcctc cggtgaaggg gaggtcgatg
    20221 agccagttgc tgaagtggat gtccatctgc tcgcgcgcga cgtactttcc ggagctggtg
    20281 aagagctcct tgccgtccag ggagtacgtg accttcccgt ccatggcggt gatcaccatg
    20341 gtgtgccagc ccgcgaggct ccgcttgacg gtgttgtgga cgcggtccgg cgggtcggcc
    20401 ttgtaccagc tgacgttgtc gagctgcgga cccaccgaac cccagccgcc gttcggcagg
    20461 tactcgaagt cgagttcgct gtagttctcc gaggagtcgg aggaggagat cgggaagaag
    20521 gtctggacga cgtggtcgcc gtcgcgtccg ctcgtgggcc tgtcgctgag gtggacccgg
    20581 gcggcgtagg ttcccgtgaa gaagttcccg ccggtggtct gcacctcggt ctgcgtggtg
    20641 ccctgcgcgg tgccgtccgt ggaggagcgc aggcggagga ccttgcccgc ctcggccgtc
    20701 tggtcggagg ggaaggcggc gccgtcggcg ctccaggtgt ccttgatgcc cggaccgccc
    20761 ccgccggtgc ggacctccca gccgtgggcg gcgagggaag ggtcgtcggc gccggtgtag
    20821 tcgaagtcgt cgaacagggt tcccggcggg ccggtcggcg tcggtgaggc ctcccgcgcg
    20881 ggcccggcgg cgtcggcgcc gccggtcgcg ggggcggcgg aacacgcggc cagtacgcac
    20941 aggagggcgg gcagcgtgag cgcggtccac gcgcggcggc gagaggtgcg gcggggctgg
    21001 ctcacacggg ctccttgggg cgtagaggcg gtgactggac acgcccgttg gcatgcggac
    21061 cgatcgctga tcgcatgaat cgagcggtca tcctagcgaa ggtttccagc catctcgccg
    21121 cgtgttcgcg acccggtcat tcaagggtct ggaagcgctc gtcgacatac cgatccggtt
    21181 acggtgctcg atcggaccat gtcaaatacg tacatcgcac gccaatcgat tcagcccatg
    21241 cgctacggtc cgctctacgc ttcagcggtc tccccaccct gcacaaaaag gccacaactc
    21301 atgcgccacg tcgccacatc ctcccggcgc ggatcggtcc actcggtaca gcccggcatg
    21361 gctgaatcac atcagttcgc gccggcgccc ataccggtgt tcgtcgacca gtcgggcctg
    21421 cgcagccgtc agctgcgccg cctcggctgg ccggtctccg tggtcggcgc gatgctcgcg
    21481 gccgccatgg gcagcagcct catcggcgtg cagtcggacg ccccggcgat ggggataccc
    21541 ccgaagccct cctaccagcc caccaagggg cccctgtcgc cctcctggcc ctagggaatg
    21601 tcgtgctgat caggccggat cagcacgaca tcccctagcg ggcgaagtcc gcaaatcctc
    21661 tcgtgaagcg tccggccgtc acgccggacc tcgcgacctt ccacggcgta ccggggccct
    21721 cgtgccaccc ggagcgacac ctgcgggccg ggccgagcgt gcctgaccgt ccgcaccacc
    21781 catctccagg agcacccttg tcccgccacc agcgtcgtcg gcagtccctg ctgagaccgc
    21841 gccgactggc tgcgccgccg ctgcgcttct tcatgccgct gtccctgctg gcctgcctgc
    21901 tcgcactgct cgtcctgcgc ggcctcgcca ccaacgaggc gttccacgac acccgggtcg
    21961 cgacctcggt cgacaagacg acggtgcccg agaacctgct caagggcggc ccggtcatcg
    22021 acgcgcgcgg cagcaggaac gagcgccccg tgagctaccg gatccccgac cgcaccgtgg
    22081 tcctcagctt cgacgacggc ccctcgccgg agtggacccc gaagatcctg gccgtgctcg
    22141 cggcccacga cgtccgcgcc gacttcttcg tgaccggctc gatgaccacg cgccacccgg
    22201 agctgatccg gcagatcgtc gcgggcggcc acgagatcgg cctgcacacc ttcacccacc
    22261 ccgacctcgt gtaccagtcc gaggcccgga tcagctggga gctggcgcag acgcagctgg
    22321 ccctggccgg cgtcgcgggc gtccacagcg cgctgttccg cccgccgtac tcctccgacg
    22381 cctcggcgct cgacgactgg aactacccgg tgatcaagta cgtgggctcc cgcggctacc
    22441 tcaccgcgtt catcgaccgc gacacccacg actggaagcg ccccggcgtc gacgcgatcg
    22501 tcgaggcggc gatgccccgc aagcccggcg cgggcgaact ggtcctgctg cacgacgcgg
    22561 gtggcgaccg taccgagacc ctggccgcgc tcgagcagat catcgtgaag ctgaagggcg
    22621 agggataccg cttcaccacc atctcc
//
