LOCUS       NZ_LIVV01000001        22697 bp    DNA     linear   CON 28-MAR-2024
DEFINITION  Streptomyces sp. CB02009 scaffold1, whole genome shotgun sequence.
ACCESSION   NZ_LIVV01000001
VERSION     NZ_LIVV01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CB02009
  ORGANISM  Streptomyces sp. CB02009
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 1660693)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1660693)
  AUTHORS   Yan,X., Ge,H., Hindra,F., Yang,D., Huang,T., Crnovcic,I. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-AUG-2015) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC Genomics Workbench v. 7.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905825.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:41:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,214
            CDSs (total)                      :: 8,139
            Genes (coding)                    :: 7,984
            CDSs (with protein)               :: 7,984
            Genes (RNA)                       :: 75
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 51 of 155
            Pseudo Genes (incomplete)         :: 117 of 155
            Pseudo Genes (internal stop)      :: 15 of 155
            Pseudo Genes (multiple problems)  :: 26 of 155
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:06:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1131828
            Orig. end                         :: 1154525
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LIVV01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22697
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="7"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22697
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22697
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12697](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12697)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    complement(782..796)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.75"
                     /tool="antismash"
     misc_feature    1333..1346
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.46"
                     /tool="antismash"
     gene            1453..2286
                     /locus_tag="AMK27_RS05045"
                     /old_locus_tag="AMK27_04945"
     CDS             1453..2286
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018104916.1"
                     /locus_tag="AMK27_RS05045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_04945"
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_073902772.1"
                     /transl_table=11
                     /translation="MILVTGATGNIGSSLLDELRAHDAGPLRGLTRDAARAGFPEGVEA
                     AEADLSDPASLKPALDGVRALFLLPHLGPDADILAAARRAGVEHVVLVSSITVQTHPHL
                     GPAAEKAAVEELLKASGMAWTILRPTQFASNTLMWAPSIRAHETVHAPYADTALPTIHP
                     ADIASVARVALTEPGHRGCTYALTGPERVSPRGQIEAVAAALGRRILCAEISRAEARSQ
                     MAAVFGPESADAVLDVTGGDVNDELLRVRDTVPRLTGTPARPYRQWALEHADAFL"
     gene            2321..2752
                     /locus_tag="AMK27_RS05050"
                     /old_locus_tag="AMK27_04950"
     CDS             2321..2752
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010640810.1"
                     /locus_tag="AMK27_RS05050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_04950"
                     /product="hypothetical protein"
                     /protein_id="WP_073902773.1"
                     /transl_table=11
                     /translation="MPLSHIVLSSGRSIELTELRMSSVYGGMLEGYPCKRVNDLQVSGL
                     QLQAERAFPSLPVHLVPPVRAYPDQSGGAFGPVEVLPSVACIGVFGSTAIAPDLDPVLH
                     RSALTVAWFQPTPDVPSGEEADGALRSIHWEELAQDYEL"
     gene            2848..3360
                     /locus_tag="AMK27_RS05055"
                     /old_locus_tag="AMK27_04955"
     CDS             2848..3360
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010985292.1"
                     /locus_tag="AMK27_RS05055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_04955"
                     /product="hypothetical protein"
                     /protein_id="WP_073902774.1"
                     /transl_table=11
                     /translation="MSSSFQTIVDLDATAEDAVAHGARVAAWLVGEGIVRLPDHDPGPR
                     WDRATGFQEALGSEGLAVVTGRTVFFSPQHTGPPVCPYCAVAFGDEHREAFSPAMDAWW
                     NTGCAEVPCPGCGRVVPLAAWEWAGDGLAFAYLGFEFRNGPALLPEFVAQLGRVIGHRT
                     RFVRGRI"
     misc_feature    2857..2871
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.96"
                     /tool="antismash"
     gene            complement(3481..4290)
                     /locus_tag="AMK27_RS05060"
                     /old_locus_tag="AMK27_04960"
     CDS             complement(3481..4290)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015038413.1"
                     /locus_tag="AMK27_RS05060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_04960"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_073902775.1"
                     /transl_table=11
                     /translation="MGLKGKYTAHIAVAASAVAISLAAWGATALTNTEAAARTGAGSQG
                     AGPEERTKGPESGPPPVSKVRMPQGIAHAAEAGGKAVNITIDDGPDPQWTPQVLDVLKQ
                     HNVKAVFCMVGPRAKEFPELVKRVVADGHRLCDHTTSHDTAMDKKSVAYQKQQILDAKR
                     MIEDAAGGAKVEYYRAPGGAFTPDSRRIAAEAGMRPLGWNVDTKDFEKPGTGAIVGTVK
                     HELSNGPTILFHDGGGDRAQTVEALKQVLPWLKEQGRPFSFPVRTAP"
     misc_feature    complement(4314..4331)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 20.42"
                     /tool="antismash"
     gene            complement(4525..5367)
                     /locus_tag="AMK27_RS05065"
                     /old_locus_tag="AMK27_04965"
     CDS             complement(4525..5367)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015038414.1"
                     /locus_tag="AMK27_RS05065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_04965"
                     /product="pyridoxamine 5'-phosphate oxidase family protein"
                     /protein_id="WP_073902776.1"
                     /transl_table=11
                     /translation="MSTFEHAGQQGTTTLRTTRPGSDGEHLVQQRMGTTERADRFYGDQ
                     VLDRLNSRMREFVNRQEMFFLATADRHGGCDNTFRAGPPGFLHVLDDETLAYPEYRGNG
                     VHASLGNIEENPQVGILMVDFLQDRIGLHVNGRARSVADDAMRRAHPWLPADQVPGRRA
                     LVWVVITVEEAYIHCAKHIPHLQKVPARGHGRSWGTDDVKRKGGDFFGAADEAPERGPF
                     LPPPRPDADAATWRAEAERVLERAERYSLGEGSGNGSGVESTVGAQPFSGWFRRSTSV"
     gene            complement(5364..6758)
                     /locus_tag="AMK27_RS05070"
                     /old_locus_tag="AMK27_04970"
     CDS             complement(5364..6758)
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1094: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017236461.1"
                     /locus_tag="AMK27_RS05070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_04970"
                     /product="globin domain-containing protein"
                     /protein_id="WP_073902777.1"
                     /transl_table=11
                     /translation="MEAPTTPSADGYGSGAAAAGGQGGGWFGHGTAGARGPQTPSHPTA
                     GRSAPQPARPAAPRPAPTPPPTTAAAAAAAAAAAARTGAGAGASVPSATELLQRTMAEI
                     EPIADRVTSYFYALLFLRHPALRDLFPAAMDAQRDRLFKALLTAATHADDPVTLTTYLT
                     HLGRGHRKYGTLPEHYPAVGEALIGALARHAPETWGPRTEAAWVGAYTTISQIMIDAAT
                     EDELRAPAWWQAEVVAHVMRTKDVAIVTVRPDGPYPFLAGQYTTLETPWWPRVWRHYSF
                     ASAPRSDGLLSFHVKAVPAGWVSNALVHRARTGDVIRLGPPAGSMTVDHTSDSGLLCLG
                     GGTGIAPIKALVEDVAQHGRRRSVDVFYGARRNNGLYDIDTMLRLQQSHPWLSVRPVVD
                     DGPVGLLSGGIPQAVREFGPWHTHDAYLSGPPGMVRSSLDTLVGIGIPTHRIRHDSIEE
                     LVGATT"
     misc_feature    complement(7009..7023)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.68"
                     /tool="antismash"
     gene            complement(7143..7901)
                     /locus_tag="AMK27_RS05075"
                     /old_locus_tag="AMK27_04975"
     CDS             complement(7143..7901)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015038607.1"
                     /locus_tag="AMK27_RS05075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_04975"
                     /product="phosphotransferase"
                     /protein_id="WP_073902778.1"
                     /sec_met_domain="APH (E-value: 1.4e-19, bitscore: 67.4,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDEVTVVVAHSARATLRVGDVFLKVDADQARIDVEVEAMSLAPVP
                     TPEVLWRKPSVLAIAAVPGTTLGRLGGPSTGSSAGWAAAGAAIRKLHDAPLPPRPGRAG
                     RSLVALAAELDDECTLLVSNGLLPTDLVTRNRQVAEAALRPWTPAFTHGDLQIAHVFVD
                     GDEVTGIIDWSEAGRGDALYDLATFTLGHEEHLDDVLAGYGADVDIDIDLDVIHGWWSL
                     RSLLAVRWLAEHGFDPFAPGCEVDVLRSRM"
     gene            8018..8611
                     /locus_tag="AMK27_RS05080"
                     /old_locus_tag="AMK27_04980"
     CDS             8018..8611
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019884431.1"
                     /locus_tag="AMK27_RS05080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_04980"
                     /product="DinB family protein"
                     /protein_id="WP_073902779.1"
                     /transl_table=11
                     /translation="MIDDFAKDNLHGRLRRDRTSLLWKLDGLSEYDVRRPVTATGTNLL
                     GLVKHLATVEARYFGEVFARPSPEPLPRWQDSDGSDLWATEDETRDQIVGYYRRTWEHS
                     DATIDELSLDAPGHVPWWPEPHADTNLFAVLVHVLGETVRHAGHADILRESLDGRTGMR
                     PEFEQPIDEEARAAHRAKIEQAARSAAQRSSRVG"
     gene            complement(8673..9656)
                     /locus_tag="AMK27_RS05085"
                     /old_locus_tag="AMK27_04985"
                     /pseudo=""
     CDS             complement(8673..9656)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006377975.1"
                     /locus_tag="AMK27_RS05085"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_04985"
                     /product="phosphotransferase"
                     /pseudo=""
                     /sec_met_domain="APH (E-value: 2.3e-23, bitscore: 79.8,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGWSDGIEGIGADRDSRSWGATRSWVEKGLSEAEHIERVVRLRGG
                     WTSEMRRLDLHGPGGRRSLVLRSFVKPFFVRHAEGLLTREATILRLQGATDVPAATLAA
                     VDATAQHCDHPSLPMSLLPGTVRLDDEGADDRAELLPRQLVRIHRLPVTAEQRPRAYQA
                     WASPERVTIPAATERPALWERAVDVIRQEPPDHQGCFLHRDFHPGNVLFTDTGGDLRIS
                     GVVDWVETSWGPADLDVAHCSTALALLHGVPAGMRFADRYVAAGGVLSEDRSAHL"
     gene            complement(10001..12697)
                     /gene="lanKC"
                     /locus_tag="AMK27_RS05090"
                     /old_locus_tag="AMK27_04990"
     CDS             complement(10001..12697)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038151.1"
                     /locus_tag="AMK27_RS05090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_04990"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_073902780.1"
                     /sec_met_domain="micKC (E-value: 3.6e-135, bitscore: 448.4,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="APH (E-value: 1.6e-06, bitscore: 24.6,
                     seeds: 156, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 3.8e-12, bitscore:
                     42.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLEGFGEALADREYYLPLPSVADPGPRFAPREVPQGLHGVGQGIW
                     TVWGGPRAALAEQGWKIHVSARLDRAQHVLDTVAGICFSEGVPFKHLSARLFFLFLHHK
                     HASRAQAGKFCAVYPPDTATARRLLARLRDALDGEEGPYVLTDRRFRDSQTVHYRYGSF
                     GARSRLRPDGTREGLVLDGSGREVVDLRLPAFHLPAGIADPFAEDEEKPHEGPILIRDY
                     EVTRAVRLSNAGGTYQARDRRTGRTVFLKEARAHNGLVFDGTDAQQRLRHEYGVLRELH
                     AAAPGVGPEPLDHFTEWEHDFLVTEYVAGQPLVSWLSRSSPLARADRTTESVAVYYEVC
                     RRLLAALDASLKRLHAAGYRFGDLSLGNVMVTPSGGVRLVDFEAASALSSAPSGIGTPG
                     FTPPPGLLRAAFDPLIQDRYGLSAVAFALLAPFNETAEHAPANLALLRRDLADAAPPPD
                     LWQRATAFLLAEERAQEPFLPQGRPQHRARGRGRTHGPPQGRAQGHGVSDFAPSPAELD
                     SDPRGCLTRLSEKVAAGLLEMADADRPEWAFPPSPEAFRTNNVCVAYGTAGVVHALHRA
                     GAAVPEEIRERLRRDTLAQRDALPPGLLVGSAGIARVLADLGLLDEAADLLRGADDHAL
                     TTSCSTLAGGRAGVGLGWLALHRLTGDGGHLERAAAAGERLLRIPDLRPTLGEHDARGL
                     LHGRSGLALFLHRLACDTGEARYREAGRRLLHEELDRTFPLDDGSLSVSDNAQLTRAMP
                     YLATGAAGVAAVLTRYVATRYVDTAPDERCAAALPKLVAGVRVSCATKEAGLYRGLAGL
                     SWFLTGHAELTGTDAAREDALRAATGLVKYAVPYRHGVRFLGAGSQRFTADVSSGGAGV
                     LLALHRLLAGPLLTEPHHARPRIPAVP"
     gene            complement(12918..13691)
                     /locus_tag="AMK27_RS05095"
                     /old_locus_tag="AMK27_04995"
     CDS             complement(12918..13691)
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123: polyprenol-monophosphomannose synthase ppm1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008412403.1"
                     /locus_tag="AMK27_RS05095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_04995"
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="WP_073902781.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 5.3e-31,
                     bitscore: 104.2, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLVSVVMPVYNSAATLGASVRSVLSQTHSDLELLVTDDKSSDDS
                     FDLLMEFARQDERVKPETAAVQGGAGRARNLAIERARGDYIAFLDSDDLWLPEKAERQI
                     AFAAAGDAPLTFTSYYKMDADYAGESVDFTPNGRVVRAREHVDYRAMLVRDYIGALTAM
                     YDRNALGTRLMPEMRKRQDYALWLSIMRDGADARGLTEPLAVYRAHQAGSLSSNKLSLV
                     PYNWELYRQHEGLSVPRATRALAGAVWQSLRNSRI"
     gene            13856..14149
                     /locus_tag="AMK27_RS05100"
                     /old_locus_tag="AMK27_05000"
     CDS             13856..14149
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008408300.1"
                     /locus_tag="AMK27_RS05100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_05000"
                     /product="hypothetical protein"
                     /protein_id="WP_073902782.1"
                     /transl_table=11
                     /translation="MTDESRRPLSELHEGETVEATITSHQPWGLTARLNGYEPVGASLD
                     VIRRGGEAGVRRLAQELPPVGATVDLVVGEVRAWHHEPWVWVDLTAPGHGED"
     misc_feature    13902..13922
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.13"
                     /tool="antismash"
     gene            complement(14288..15643)
                     /locus_tag="AMK27_RS05105"
                     /old_locus_tag="AMK27_05005"
     CDS             complement(14288..15643)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024753.4"
                     /locus_tag="AMK27_RS05105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_05005"
                     /product="PQQ-binding-like beta-propeller repeat protein"
                     /protein_id="WP_073902783.1"
                     /transl_table=11
                     /translation="MAALVHEMPSGRRSRRALSMTVALLFSLCALTAGCSSDAEEWSVA
                     WDTPAEREAEQHGNGAWLSGDTLVHSRFDAVRGYDVRTGKRSWGHVPPGRSAVCHAADD
                     ADNSVLVLTRDGDGTSAPAKGTACADVVAIDMSSGREIWQTRLPALDTWASRLQSFTVS
                     AGSGIAVLLRGDDLQAVDVRTGRPRWKAALPKGCVPGTTAMAERQVTALLACGGTEYLL
                     GDKVPSDAELFVATFAPASGALLWSAPLGNRSAVPWDARADFISADPVVVAASASGDSD
                     SGAYFSFSRNGRPNPPIGFSGPYGEIAFSARLTAAADDSRLYALPLHRVRNSRVDPHRL
                     TAFDLATGDPVWGGTVDDDRLDGDTGYRVIPQDGKIKVLTFRRETPFFGDPSSTYGLRV
                     LDGATGRQREVHRFPEGDDEVDTLFEHEGRLIGARYASYESRNKPFTSYEHR"
     misc_feature    complement(16081..16097)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 21.09"
                     /tool="antismash"
     gene            16107..16460
                     /locus_tag="AMK27_RS43440"
                     /old_locus_tag="AMK27_05015"
     CDS             16107..16460
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK27_RS43440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AMK27_05015"
                     /product="hypothetical protein"
                     /protein_id="WP_073902785.1"
                     /transl_table=11
                     /translation="MADVEFGPADDVLHFVNDCFEDLIFWQRRGEEFATLLRSDLDWEP
                     RRITPDMLRFGALASEFDGEELPESLRGLAGAPSIGDVILDIAEAMWLGACFSTTEWSR
                     RPSTARRTGSDQS"
     misc_feature    complement(16535..16549)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.65"
                     /tool="antismash"
     gene            16874..17044
                     /locus_tag="AMK27_RS05120"
     CDS             16874..17044
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK27_RS05120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_274535737.1"
                     /transl_table=11
                     /translation="MIVKQVTDEGDTGADASTRFAREVAGLSLAGRASGPAVAPAVLAT
                     DLPSRVMTEMS"
     gene            complement(<17054..17317)
                     /locus_tag="AMK27_RS05125"
                     /pseudo=""
     CDS             complement(<17054..17317)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003946701.1"
                     /locus_tag="AMK27_RS05125"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGRGDLSDAEWEPLRPFLPASNGRCGWREHRQMIDGVLHRVRTRV
                     QWRDVPERFGPWKTVYKRHRLWSADGTWERLLKQVQAAADAEG"
     gene            complement(17349..17933)
                     /locus_tag="AMK27_RS05130"
                     /old_locus_tag="AMK27_05020"
     CDS             complement(17349..17933)
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010062551.1"
                     /locus_tag="AMK27_RS05130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_05020"
                     /product="S1 RNA-binding domain-containing protein"
                     /protein_id="WP_073902786.1"
                     /transl_table=11
                     /translation="MDWQSESPGLWAFLASLHSGDILSGTVAAIERFGVFVALDDGPAH
                     PLFPGVGFIVIPELSWRHIDAPTDVVHVGQRVSCEFLQFDTYNAEARLSLRAWEPDPLQ
                     AFADRTAVGQELRGTVDKVLPFGIIVGLGDGIAGLVPFREAPGRPAVSLVEDFEAGEKV
                     TVVVTEIDLPTRRVLLSRPKVARREGVVPVT"
     gene            complement(18458..18925)
                     /locus_tag="AMK27_RS05135"
                     /old_locus_tag="AMK27_05025"
     CDS             complement(18458..18925)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025789.4"
                     /locus_tag="AMK27_RS05135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_05025"
                     /product="SUKH-3 domain-containing protein"
                     /protein_id="WP_073902787.1"
                     /transl_table=11
                     /translation="MSSWSAEVEDVLEASGWTPGRKVDTARWRSMFASVGLDMHAAAET
                     FLEEFGGLTVHVSGPGITCARTPFELDPELAWGDEERFMEWGEAIGRHLYPLGEVDQGR
                     FFLGIDEVGVIYLVEGWIAEFGPMPQAMENLVLGVNPRTIDDWYEPGGQPS"
     misc_feature    complement(18910..18925)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.53"
                     /tool="antismash"
     gene            complement(19154..19885)
                     /locus_tag="AMK27_RS05140"
                     /old_locus_tag="AMK27_05030"
     CDS             complement(19154..19885)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014145745.1"
                     /locus_tag="AMK27_RS05140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_05030"
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="WP_073903972.1"
                     /transl_table=11
                     /translation="MELLAAEAAGRGMDVLAAEEASAATGPAYWYGGPVAGARLAGLLG
                     FALLEPADEWLAELPEEFTGREVRTATVLDAWAIERPTFVKPPRDKSFEADVYADGSRL
                     PGDLDPATPVLLSDVVTFAAEYRLFLLDGQIATGSRYAVFGRLAPLPLDKHGPIAAELA
                     AFVDRLVAAAEPALPSAVVVDVGQLLDTYRPGYRWAVVEANMAWFSHAYAAAPARVLDV
                     VLRAAGPRENVQPADLPFVRH"
     misc_feature    complement(19972..19981)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            20172..20645
                     /locus_tag="AMK27_RS05145"
                     /old_locus_tag="AMK27_05035"
     CDS             20172..20645
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018837625.1"
                     /locus_tag="AMK27_RS05145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_05035"
                     /product="hypothetical protein"
                     /protein_id="WP_073902788.1"
                     /transl_table=11
                     /translation="MDSAVLQQMLDEAFDHAVVHHGYTNYMRDYEVIVYATAAPDTGIQ
                     PAYLRYLFRYCVEARCETSVPAATWRVSLDDRLVDYETGADLDGYVWGVKWHLLYPGAK
                     LLPESEVARRWSRAVGIDFHDVLIESNAHRLTLVFSDLQVTEVPTGYTPFVTD"
     gene            21035..21691
                     /locus_tag="AMK27_RS05150"
                     /old_locus_tag="AMK27_05040"
     CDS             21035..21691
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014157096.1"
                     /locus_tag="AMK27_RS05150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_05040"
                     /product="hypothetical protein"
                     /protein_id="WP_241847306.1"
                     /transl_table=11
                     /translation="MRRSPLLFTVPIVLLVLLTAVLGWEAVRANMSAAARAEWPWRLQL
                     LDMEPLGSLLAVAAGAVLARAQYARTVRPALGWRADWTTGHLRGGVPEWQVGLLNGGSH
                     TVVIEAYECRALLRGEDPQHAAPWTDVQGVAEVLTGAGLTVGEDFQLVTVGRFPLVGTG
                     SYETTMLGAFSQRFVDEVEALHIRVRVSDVVGDSHERTLDALRGARSTAYQRPAP"
     gene            complement(21673..22566)
                     /locus_tag="AMK27_RS05155"
                     /old_locus_tag="AMK27_05045"
     CDS             complement(21673..22566)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (24-278). E-value:
                     8.1e-27. Score: 86.3. Matches aSDomain:
                     nrpspksdomains_AMK27_RS05155_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014157101.1"
                     /locus_tag="AMK27_RS05155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK27_05045"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_073902790.1"
                     /sec_met_domain="PF00561 (E-value: 9.2e-23, bitscore: 77.6,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2e-11, bitscore:
                     41.4, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGLPVRTDDGRLLVAEEWGNPSGTPVLLFHGTPGTRLGTLLPGLA
                     EQHPGFRFLAYDRPGYGESRRSPGRRVADAARDAGAVADAFGVERFAVVGRSGGGPHAL
                     ACAALLPDRVRAAVVLVGLAPPDAAGLDWYAGMTPFNVREYGLARAHLDGRDPGGLERD
                     LAARADAIRRDPVRLLDDLRAELSPHDLPVVEDPRVRAVLLRTYQEALRVSHHGWLDDC
                     LAFVRPWGFDVASVAAPVLLWHGLDDAFSPVSHTRWLAGRIPGAEPVLVPDAGHFAAQW
                     ALPDVLRWLDGQGAGR"
     aSDomain        complement(21733..22494)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMK27_RS05155_Abhydrolase_1.1"
                     /evalue="8.10E-27"
                     /label="AMK27_RS05155_Abhydrolase_1.1"
                     /locus_tag="AMK27_RS05155"
                     /protein_end="278"
                     /protein_start="24"
                     /score="86.3"
                     /tool="antismash"
                     /translation="PVLLFHGTPGTRLGTLLPGLAEQHPGFRFLAYDRPGYGESRRSPG
                     RRVADAARDAGAVADAFGVERFAVVGRSGGGPHALACAALLPDRVRAAVVLVGLAPPDA
                     AGLDWYAGMTPFNVREYGLARAHLDGRDPGGLERDLAARADAIRRDPVRLLDDLRAELS
                     PHDLPVVEDPRVRAVLLRTYQEALRVSHHGWLDDCLAFVRPWGFDVASVAAPVLLWHGL
                     DDAFSPVSHTRWLAGRIPGAEPVLVPDAGHFA"
ORIGIN
        1 agcgcctcct acgcggagat gcggagcgag gtcgcacgga ccctcgcgga cgcccgcgag
       61 ctcggcaacg aactcggcga ggcgggggcg ctggcggtcg ccgcgttcgg cgaggcctac
      121 gagggcgacg tgaccgcggc gagcgcgtac gcggcgcagg ccgccggagt cctggacggc
      181 ctgcccgacg gcgacctcac cgcactgtgc gaaccgctgg gcagactggc atgggcggag
      241 gccttcctgg gccgctacac ggacgcggaa cgccatgccg accgcggcct cggcatcgcc
      301 cggcgcagcg gacagatcta cctcctgccg ctcctgctgc tgtgcaaggc acacgtacgc
      361 atccagacct gccggctgcc gtcggcccgg gaactggcgg acgaggccga ggacatcgcc
      421 cgcggcatcg gcagcactga gctgctcgcc ttcgtcctgg ccaacaaggc ccaggtgtgt
      481 gtcgcggcct ccgcacccgg cgacccggag gcactggcgg ccgcggagga ggccgtcgcg
      541 gccatggggc cgagcgacaa ctggcgggcc tccatggcct ggtgcatgct cggatacgcg
      601 gcactcaccg gcggcgatcc gcaccgagcc cgggacgcgc tcctcaaggc cgggggagac
      661 gacctgcggg gactgcaacc ctcgatgcgc cctctcctga tggaactcct cgtcacggcg
      721 gccctcttca caggtgacgt gccggccgcg tccgcgtggg ccgagcaggc cggaagggaa
      781 gcggaacagc tcggcctccc cgtgcaacgc gcctccgcga tgcggagcgc ggcacagctc
      841 gccctgcacc acggcgacgc cggaagggcg gcgacgctgc tctccgaggc ggcggcggag
      901 tgcgcccggt cgggtgcggt gttctgggag gcgcgctcac tgctgctcgc ggctcccgcg
      961 atgacggccg ccgggttcgg ggcgcgcggt gaggccatgt ggaagcaggg gcaccggctg
     1021 gccacggccg gaggcgcggg tctgctgctc ggactggccg agctgacgag gcgacccgca
     1081 ccacagcccc acccccgtac gtcctcgtcc tccaccgtcc cgccgcggct ggcctccttg
     1141 acggcacgcg aacgggagat cgccgaactg gcggcggagg gcctcacgaa ccgggcgata
     1201 gccaccaggc tctacctcag tccgcgcacc gtggagaccc acctctcacg ggtgttccgc
     1261 aagacggagg tcgcgacgag ggcgagtctc gccgccttga tggcccgctc ctgacgccca
     1321 ggactccgcc cacgtacgca catgcatccc acccggccgg agcaggaggc gacgcacgct
     1381 tgacctcaag caagagtgag gttctaccgt cctgtctacg cgatcacctg accgacgacg
     1441 ggacaccacc gcatgatcct cgtgaccgga gccaccggaa acataggcag ctcactcctc
     1501 gacgaactgc gtgcacacga cgccgggccg ctgcgtgggc tcacccgtga tgccgcgcgg
     1561 gccggcttcc ccgaaggagt cgaagccgcc gaggccgacc tgtcggaccc ggcgtcgctg
     1621 aagcccgccc tggacggtgt gcgcgcgctc ttcctcctgc cgcacctggg cccggacgcc
     1681 gacatcctcg ccgccgcgcg gcgggcgggc gtggagcacg tcgtactggt ctcctccatc
     1741 accgtccaga cccaccccca cctcggcccc gccgccgaga aggcggcggt ggaggagctg
     1801 ctcaaggcga gcggcatggc gtggacgatc ctgcggccga cccagttcgc ctccaacacc
     1861 ctgatgtggg cgccctcgat ccgcgcgcac gagacggtcc acgcaccgta cgcggacacc
     1921 gcgctgccga ccatccaccc ggccgacatc gcctccgtgg cgcgggtggc cctgaccgag
     1981 cccggccacc gtggatgcac ctacgccctg accgggccgg agcgggtctc cccacggggg
     2041 cagatcgagg ccgtcgcggc agcactcgga cgccggatcc tctgcgcgga gatcagccgc
     2101 gcggaggccc gcagccagat ggccgcggtc ttcggccccg aatccgcgga cgccgtcctc
     2161 gacgtcaccg gaggagacgt gaacgacgag ctgctgaggg tccgtgacac ggttccgcga
     2221 ctcaccggaa cgccggcccg cccgtaccgg cagtgggccc tggagcacgc cgacgccttc
     2281 ctctgagccg cgccggccgg cgtgcgctta gggtgtcggg atgccgctga gtcacatagt
     2341 cctctcgtcc ggtcgttcga tcgagctcac cgagctgcgg atgtcctcgg tctacggggg
     2401 gatgctggag ggctacccgt gcaagcgcgt caacgacctc caggtcagcg gcctccagct
     2461 gcaggcggaa cgcgcgttcc cctccctgcc ggtccacctg gttccgcccg tccgcgccta
     2521 cccggaccag tccggcggcg ccttcggccc tgtggaggtc ctgccctccg tggcgtgcat
     2581 cggtgtcttc ggctcgacag cgatcgctcc cgacctcgac ccggtgttgc accgttccgc
     2641 tctcaccgtg gcctggttcc agcccacccc ggacgtcccg tcgggcgagg aagccgatgg
     2701 tgcgctgcgc agcatccact gggaggaact ggcccaggac tacgagctct gacgacgcgt
     2761 gctcttcacg gtgtgcgtcg cgtccgggcg gtacggatcg ggttgtacgg gttttgtgga
     2821 gccgagtagg ccgcttaccg ttcggctgtg agcagctctt ttcagacgat cgtcgacctg
     2881 gacgcgaccg ccgaggacgc cgtcgcgcac ggggcgcggg tggcggcgtg gctggtgggc
     2941 gagggaatcg tgaggctgcc ggatcacgat ccggggccgc ggtgggaccg cgcgaccggg
     3001 tttcaggagg cgctcgggag cgaggggctg gccgttgtca cggggcgtac ggtgttcttc
     3061 tcgccgcagc acaccgggcc gccggtctgt ccgtactgcg cggtggcatt cggtgatgag
     3121 caccgtgagg cgttctcgcc ggccatggac gcatggtgga acaccggctg cgccgaagtg
     3181 ccgtgcccag ggtgcggacg ggtggtgccg ctggccgcat gggaatgggc cggcgacggg
     3241 ctcgctttcg cgtacctggg gttcgagttc cggaacgggc ccgcgctgct gccggagttc
     3301 gttgcgcagc tgggccgggt gatcgggcac cggacgcggt tcgtgcgggg aaggatctag
     3361 ccgccctcgc cgaagaggtc tggcccccgt gaggatcttg gagcgatgga gatctccgga
     3421 ccggctctca taccggacac ggccaggtcg aaggagatct ccagcgcgag ccgcccgacc
     3481 tcagggagcc gttcgcacgg ggaagctgaa ggggcgtccc tgttccttca gccacggcag
     3541 aacctgcttg agggcctcga cggtctgggc gcgatcgccg cctccgtcgt ggaacaggat
     3601 cgtcggcccg ttggacagct cgtgcttgac cgtgccgacg atggcccccg taccgggctt
     3661 ctcgaagtcc ttggtgtcca cgttccaccc cagcggccgc atccccgcct cggcggcgat
     3721 acgccggctg tcgggggtga acgcgccgcc cggcgcccgg tagtactcca ccttggcgcc
     3781 cccggcggcg tcctcgatca tccgcttcgc gtcgaggatc tgctgcttct gatacgcgac
     3841 ggacttcttg tccatcgccg tgtcgtgcga cgtggtgtgg tcgcacaggc ggtgcccgtc
     3901 cgcgaccacc ctcttgacca gctcggggaa ctccttcgcc cgcggtccga ccatgcagaa
     3961 caccgccttg acgttgtgct gcttgaggac gtcgagcacc tggggcgtcc actgcgggtc
     4021 gggcccgtcg tcgatggtga tgttcacggc cttcccaccc gcctcggcgg catgggcgat
     4081 cccctggggc atcctcacct tcgacaccgg cggcggaccg gactccggcc ccttggtccg
     4141 ttcctcaggc ccggccccct gcgagcccgc tcccgtccgc gcggcggcct cggtgttggt
     4201 cagcgcggtg gcgccccacg ccgccaggct gatcgcgacc gccgaagccg ccacggctat
     4261 gtgtgcggtg tacttgccct tcagccccat gtcctgccac tcctcgcccg ttctctacgc
     4321 tctcccggat aaggggacgg tagacacggc cggaaggttt cacccgatcg ggtcccaaga
     4381 acggaaacgt gcagcgtgag gggctcaggc gacgtctcag gcgggagttg ggagagggac
     4441 tgggcagtgc ctccggcacg gactcggact cggactcggg ggtcggagtc ggactcggct
     4501 tcgaaatcgg actgggactt ggcctcagac cgaggtgctt ctgcggaacc agccgctgaa
     4561 cggctgcgcc cccacggtgg attccacccc ggagccgttg ccggagcctt cgcccaagga
     4621 gtaccgctct gccctctcca gtaccctctc cgcctccgcc cgccacgtcg ccgcatccgc
     4681 gtccgggcgg ggcggcggca ggaacggacc gcgctccggt gcctcgtcgg ccgctccgaa
     4741 gaagtcgccg cccttgcgct tgacgtcgtc cgttccccac gagcggccgt ggccgcgcgc
     4801 cgggaccttc tgcaggtggg ggatgtgctt ggcgcagtgg atgtacgcct cctcgacggt
     4861 gatcaccacc cacaccagcg cccttcggcc gggcacctgg tcggccggga gccaggggtg
     4921 ggcgcgacgc atcgcgtcgt cggccacgct cctggcccgg ccgttgacgt ggagcccgat
     4981 gcggtcctgg aggaagtcga ccatgagaat gccgacctgc gggttctcct cgatgttgcc
     5041 gaggctggcg tggacgccgt tgccccggta ctcggggtag gcgagcgtct cgtcgtccag
     5101 gacgtggagg aagccgggcg ggcccgcgcg gaaggtgttg tcgcagccgc cgtgccggtc
     5161 ggcggtggcc aggaagaaca tctcctgccg gttcacgaac tcccgcatcc gggagttcag
     5221 ccggtcgagg acctggtcgc cgtagaaacg atccgcgcgc tccgtggtgc ccatgcgctg
     5281 ctggaccagg tgttcgccgt cactgcccgg gcgggtggtg cgcagggtcg tcgtcccctg
     5341 ctgcccggcg tgttcgaaag tactcacgtc gttgccccga ccagttcctc gatggagtcg
     5401 tgccgtatgc ggtgggtggg gatgccgatg cccacgaggg tgtcgaggct gctccggacc
     5461 attccgggcg gcccggacag ataggcgtcg tgcgtgtgcc acgggccgaa ctcgcgtacg
     5521 gcctgcggga tgccgccgga cagcaggccg acaggaccgt cgtcgacgac cgggcgcacc
     5581 gagagccagg ggtgcgactg ctgcaggcgg agcatcgtgt cgatgtcgta gaggccgttg
     5641 ttccggcgag cgccgtagaa cacgtcgacg gagcgccgac ggccgtgctg agcgacgtcc
     5701 tccaccagcg ccttgatcgg cgcgatgccg gtcccgccgc cgagacacag caacccgctg
     5761 tcactggtgt ggtccacggt catggaaccg gcgggaggac cgagccggat gacgtccccg
     5821 gtacgggcac ggtggacgag ggcgttggac acccagcccg ccggtacggc cttgacgtgg
     5881 aaggagagga gcccgtcgga acggggagcg gacgcgaagg agtagtgccg ccagacccgc
     5941 ggccaccagg gcgtctccag ggtcgtgtac tgcccggcga ggaagggata cggcccgtcg
     6001 ggccggaccg tgacgatcgc gacgtccttc gtgcgcatga catgggcgac gacctccgcc
     6061 tgccaccagg ccggcgcccg gagctcgtcc tcggtcgccg cgtcgatcat gatctgggag
     6121 atcgtggtgt acgcgcccac ccaggcggcc tcggtccgcg gcccccaggt ctccggggcg
     6181 tggcgggcga gcgccccgat cagggcttcg ccgacggccg gatagtgctc ggggagggtg
     6241 ccgtacttcc ggtgcccgcg gccgagatgg gtcagatagg tggtgagggt gacggggtcg
     6301 tccgcgtggg tcgcggcggt gagcagcgct ttgaacagcc ggtcgcgctg ggcgtccatc
     6361 gcggcgggga agaggtcccg cagggcgggg tggcggagga agagcagcgc gtagaagtac
     6421 gaggtgaccc ggtcggcgat cggctcgatc tcggccatcg tgcgctgcag cagctctgtg
     6481 gcggacggaa ccgaggcccc tgctcctgcc cctgtccttg ccgctgccgc tgccgctgcc
     6541 gctgccgctg ccgccgttgt cgggggcggc gtcggggctg gtcggggcgc cgccgggcgc
     6601 gcgggctgcg gggccgaccg gccggccgtc ggatgcgagg gcgtctgggg cccgcgcgct
     6661 cccgccgtgc cgtgcccgaa ccagcctccg ccctgaccgc cggcagcagc ggcaccggag
     6721 ccgtagccgt cggccgacgg ggtggtcgga gcttccatcg gtctgcctcg cctcgaacgt
     6781 ctttggtcgg tcttcgtccc cggggtctgc atgtgccccg atttcttgcc gcccacggcg
     6841 tacgacgatt actcggacag gtgagcgggc ccgaccatac cccgcccgca ggaattccgg
     6901 ggattccctc cagaaccccg tcggagaagc cattttggct ggtcaggggc tggttactat
     6961 tgagttggaa gggcctgaaa gtgtttcagg tgagccatgt tcgaggaatt cgccgactga
     7021 aaactcacgc ggtgaccaga acttctccac atctgtgccg acctgatcgt ctcggtaagc
     7081 ggctggtgag acgctcagag caggccgacg ccgcagcggg tcgaagtcgt acccgcgcgg
     7141 cctcacatcc gggatcgcag gacgtcgacc tcgcagcccg gagcgaacgg gtcgaagccg
     7201 tgctcggcca gccagcggac tgccagcagg cttcgcaacg accaccaccc gtggatcacg
     7261 tcgaggtcga tgtcgatgtc gacatcggcg ccgtatccgg cgaggacgtc gtcgaggtgc
     7321 tcctcgtgtc cgagcgtgaa ggtggcgagg tcgtacagag cgtcgccccg gcctgcctcc
     7381 gaccagtcga tgatgcccgt cacctcgtcg ccgtcgacga agacgtgcgc gatctgcagg
     7441 tctccgtgcg tgaacgcggg cgtccacggc cggagcgcgg cctcggcgac ctggcggttg
     7501 cgggtgacca ggtcggtggg caggaggccg ttcgacacga gcagcgtgca ctcgtcgtcg
     7561 agttccgccg ccaacgcgac gaggctccgg ccggcacgac cggggcgggg cggcagcggt
     7621 gcgtcgtgca gtttccggat cgcggcgccc gccgcggccc atcccgccga cgatccggtc
     7681 gacggcccgc cgaggcgccc gagcgtggtc cccgggaccg cggcgatcgc gagcacggac
     7741 ggcttgcgcc acagcacctc cggggtcggg accggcgcga gggacatcgc ctcgacctcg
     7801 acgtcgatac gggcctgatc ggcgtccacc ttcaggaaca cgtcgccgac acgcagggtc
     7861 gcgcgcgcgg aatgggcgac gaccacggtg acctcatcca tgggcgacca gtattccgga
     7921 ggtgatcgcc gacgtcgccg gatttgtcgc ctgcggtgga gggggagcac gtacaggatc
     7981 ttgagagcgc gggcagcccg tggcagggtc atgtcgcatg atcgacgact tcgcgaagga
     8041 caacctgcac gggagactgc ggcgggaccg cacgtcgctg ctctggaaac tcgacggcct
     8101 gtccgagtac gacgtccggc ggccggtgac ggcgaccgga accaatctcc tcggcctggt
     8161 caagcatctg gccaccgtcg aagccaggta cttcggcgag gtcttcgccc gcccctcccc
     8221 ggaaccgctg ccccggtggc aggactccga cggcagcgac ctgtgggcga ccgaggacga
     8281 gacccgcgac cagatcgtcg ggtactaccg gcgcacgtgg gaacactcgg acgcgaccat
     8341 cgacgagctt tccctcgacg cccccggcca cgtgccctgg tggccggagc cccatgccga
     8401 cacgaacctg ttcgccgtcc tggtccacgt cctcggtgag acggtccggc atgccgggca
     8461 cgccgacatc ctgcgcgaga gcctcgacgg ccggaccggg atgcgccccg agttcgagca
     8521 gccgatcgac gaggaagcgc gcgcggccca tcgcgcgaag atcgagcagg ccgccaggtc
     8581 ggccgcacag aggtcgtctc gcgtggggtg acgtcacgtg acgtgaccgg agctccccca
     8641 gcactcgccg cacgaactac ggctacgaag cgtcaggcat agcgatggaa gagggattcg
     8701 atgtatccct ccagcctttg cgtcaggaca ccggctgtca gatcgacgcg gcccagctca
     8761 cgccacggga ccgcgacctt ctccgcgtcg ggagcgaaac ccagtacgtc cagcagccgc
     8821 cactagagat gggccgagcg atcctcggac aggacgcctc cggcagccac gtagcgatcc
     8881 gcgaaccgca tgcctgcggg aaccccgtgc agcagggcga gagccgtcga gcaatgagcc
     8941 acgtccaggt cggccggccc ccacgaggtc tccacccagt cgacgacccc gctgatccga
     9001 agatcgccac cggtgtccgt gaagaggacg ttgccgggat ggaagtcccg gtgcaggaaa
     9061 cagccttgat ggtccggggg ctcctggcgg atgacgtcga cagcccgctc ccagagagcg
     9121 ggccgctcgg tggccgcggg gatggtcacc cgttcgggag aggcccaggc ctggtaggcg
     9181 cgaggccgtt gctcagctgt caccggcagc cggtgaatgc gtacgagctg tcgcggcagc
     9241 agttcggcgc ggtcatcagc gccctcgtcg tccaggcgta cggtccccgg caagagggac
     9301 atcggcaagg aggggtgatc gcagtgctgc gccgtcgcgt ccaccgccgc cagggtggcc
     9361 gcgggcacgt ccgtggcacc ctgcaggcgc aggatggtcg cctctctggt cagcagaccc
     9421 tccgcgtgcc ggacgaagaa gggcttgacg aaggatcgca ggacgaggga gcgccgaccg
     9481 cccggaccgt ggagatccag acggcgcatc tccgacgtcc agccgccgcg cagccgtacg
     9541 accctctcga tgtgctctgc ctcggacagt cccttctcga cccaggagcg cgtcgcaccc
     9601 caactccgac tgtcacgatc cgcgccgatg ccctcgattc cgtcactcca ccccatggag
     9661 gcaggctatc caccgctgga tgtgtgacgc ctggggtgat gtcgctgagg gcggaggcga
     9721 gttgccgggg caggcggcag cgccgcctgc cccggccgtt cgcgggttcc ggccggctac
     9781 atcggctcgg ggaagatgtc gctgatgctc caggcgacgc tgaagcaggg cgggaggtag
     9841 gactcctccg gctcggtgtc cagggcctgg agcgcgagga tctggctcat gatgctctcc
     9901 acttctctcg gggtgtgtcg gtcggtgact gcgtacctcg gcacgagcgg agtcgtccgc
     9961 cgccgtgccc aggtgctcgt ggggcgcctg cacggcgccg tcaggggacc gcggggatcc
    10021 ggggacgcgc gtggtggggc tccgtcagga gcggtccggc cagcagacgg tgaagggcca
    10081 gcaggactcc ggctccgcca ctggacacat cggcggtgaa ccgctgcgaa cccgcgccga
    10141 ggaagcggac accgtgccgg tacgggacgg cgtacttcac cagaccggtc gcggcgcgca
    10201 gcgcgtcctc gcgggcggcg tccgtgccgg tgagctcggc gtgcccggtc aggaaccagc
    10261 tcagtccggc caggccccgg tacaggccgg cctccttcgt cgcgcaggag acccggacgc
    10321 cggccaccag cttcggcagc gccgcggcgc agcgttcgtc cggtgcggtg tccacgtagc
    10381 gggtggccac gtaacgggtg agcacggccg cgacgcccgc cgcgcccgtg gccaggtacg
    10441 gcatggcgcg cgtgagctgc gcgttgtcgg agacggacag ggagccgtcg tccagcggga
    10501 acgtgcggtc cagctcctcg tggagcagcc ggcggcccgc ctcccgatag cgggcctcgc
    10561 cggtgtcgca tgccaggcgg tgcaggaaca gagcgaggcc cgaacgaccg tgcagcaggc
    10621 cacgggcgtc gtgctcgccg agggtgggcc gcaggtcggg gatgcgcagc aggcgctccc
    10681 cggccgcggc ggcccgctcc aggtggccac cgtccccggt cagccggtgc agggcgagcc
    10741 agcccaggcc gaccccggcc cgcccgccgg ccagcgtgct gcacgaggtg gtcagcgcgt
    10801 ggtcgtcggc gccccggagc aggtcggcgg cctcgtccag caggccgagg tcggccagta
    10861 cccgggcgat gccggccgag ccgacgagca gtcctggggg cagcgcgtcg cgctgcgcca
    10921 gcgtgtcccg gcgcagccgt tcgcggatct cctccggcac cgcggctccg gcacggtgca
    10981 gggcgtgcac cactccggcc gtgccgtacg cgacgcacac gttgttggta cggaacgcct
    11041 cgggcgacgg cgggaaggcc cactcgggcc ggtcggcgtc agccatctcc agcagccctg
    11101 cggccacctt ctcggacagc cgggtgaggc agccgcgcgg atcgctgtcc agctcggcgg
    11161 gggagggggc gaagtcggaa acgccgtggc cctgggctcg gccctgcggc gggccatgcg
    11221 tacggccccg gccccgtgcc ctgtgttgcg gccggccctg tggaaggaac ggctcctggg
    11281 cccgctcctc cgccaggagg aaggccgtgg cccgctgcca caggtccggc ggcggcgccg
    11341 cgtccgccag gtcgcggcgc aggagcgcga ggttggcggg ggcgtgctcg gctgtttcgt
    11401 tgaacggtgc caggagtgcg aacgcgaccg ccgacaggcc gtaccggtcc tggatcagcg
    11461 gatcgaacgc ggcccggagc aggccgggcg gcggagtgaa ccccggggtg ccgataccgg
    11521 acggtgcgga ggacagggcc gaggccgcct cgaagtccac cagccggacc ccgcccgacg
    11581 gcgtgaccat gacattgccg aggctgaggt cgccgaaccg gtagccggcg gcgtgcagcc
    11641 gcttcagcga ggcgtccaac gcggccagca ggcgccggca cacctcgtag tacacggcga
    11701 cggactcggt cgtgcggtcg gcgcgagcca ggggggagga ccggctcagc cagctcacca
    11761 gcggctgccc ggcgacgtac tcggtgacga ggaagtcgtg ctcccactcc gtgaagtggt
    11821 ccagcggctc cgggcccacc ccgggggccg ccgcatgcag ctcgcgcagc acgccgtact
    11881 cgtgccgcag ccgctgctgg gcgtcggtcc cgtcgaagac caggccgttg tgggcacggg
    11941 cctccttgag gaagacggtg cggccggtac gccggtcccg ggcctggtac gtaccgccgg
    12001 cgttgctgag gcgtaccgcg cgggtcacct cgtagtcgcg gatcaggatc gggccctcgt
    12061 gcggcttctc ctcgtcctcg gcgaaggggt ccgcgatgcc cgcgggcagg tggaaggcgg
    12121 gcagccgcag atccacgacc tcacgaccgg atccgtcgag gaccagcccc tcgcgggtgc
    12181 cgtcggggcg cagccggctg cgggcgccga acgagccgta gcggtagtgg accgtctgcg
    12241 agtcgcgaaa gcgccggtcg gtgaggacgt acggcccttc ctcgccgtcg agcgcgtcgc
    12301 gcaagcgcgc caacagccga cgggcggtcg ccgtgtccgg cgggtagacg gcgcagaact
    12361 tgcccgcctg ggcccgtgag gcgtgcttgt gatggaggaa gaggaagaag agccgggcgc
    12421 tcaggtgctt gaacggcacg ccttcggaga agcagatccc ggcgaccgtg tcgagcacat
    12481 gctgcgcccg gtccagccgg gccgacacgt ggatcttcca gccctgctcg gcgagagcgg
    12541 cccgcggacc gccccagacc gtccagatgc cctgcccgac gccgtgcagg ccctgcggca
    12601 cctcgcgggg agcgaagcgc ggcccggggt cggccacgct gggcagcggc aggtagtact
    12661 cccggtccgc gagcgcttcg ccgaagcctt cgagcacgga atctcctcgc agcgtggtga
    12721 agggcggcca tgacggctgc gccagacgct agggcgggag ggtatggaaa cggttcacgg
    12781 tcggcatgtg accggtatcg ggcgggatcg gtcgcatgcc gacgatggcg cccttgccgg
    12841 gcgagggagg cggcgaagaa gtgggagagg aggcggtacg cggagaaggg ggcgttacgc
    12901 ggagaagggc gaggccctca gatccgcgag ttgcgcagcg actgccacac ggcgccggcc
    12961 agggcccgcg tcgcacgggg gaccgacagc ccctcgtgct ggcggtagag ctcccagttg
    13021 tacgggacga gcgacagctt gttggaggac agcgaacccg cctggtgggc cctgtacacc
    13081 gcgagcggct cggtcaggcc gcgggcgtca gcaccgtccc gcatgatcga cagccacagg
    13141 gcgtagtcct gccgcttccg catctccggc atcagccgtg tgccgagggc gttgcggtcg
    13201 tacatggcgg tcagcgcgcc gatgtagtcg cgtaccagca tggcgcggta gtccacgtgc
    13261 tcgcgcgccc ggaccacccg gccgttcggg gtgaagtcga cgctctcgcc ggcgtagtcg
    13321 gcatccatct tgtagtacga ggtgaacgtc aggggcgcgt cgcccgccgc ggcgaacgcg
    13381 atctgccgct ccgccttctc cggaagccac aggtcgtcgc tgtcgaggaa ggcgatgtag
    13441 tcgccccggg cccgctcgat ggcgaggttg cgcgcccggc cggcgccgcc ctggaccgcc
    13501 gccgtctccg gcttcacgcg ctcgtcctgg cgcgcgaact ccatgagcag gtcgaaggag
    13561 tcgtccgagg acttgtcgtc ggtgaccagc agctccaggt cgctgtgggt ctgcgagagc
    13621 accgagcgaa ccgatgcgcc gagcgtcgcc gccgagttgt acacgggcat gacgacggac
    13681 accaaaggca cggcgcttct ccttgttaga tcaatgacgc ttccattcaa gcactggaat
    13741 cgtagtggaa gccgccacgt gtgttgtccc tggtcaggag cgctgatcac ggttgctcgg
    13801 caggggctga ccgatgggtg gggaaacgta cggatcgaga aggcatgatg ccgccatgac
    13861 agacgaatcg aggcgccctc tcagcgagct tcacgaaggt gagacggtcg aggcgacgat
    13921 caccagccat cagccgtggg ggctcacggc gcggctgaac gggtacgagc ccgtgggcgc
    13981 ctcgttggac gtcatccgcc gaggagggga agccggggtg cggcgcctcg cccaggaact
    14041 gccgccggtg ggggcgaccg tcgacctcgt cgtaggggaa gtacgcgcgt ggcaccacga
    14101 gccctgggtg tgggtggatc tcacggcacc gggccacggc gaagactgac tgcgccccga
    14161 ggggcccgac gggacgggca tgtgaagggg gtgaaaggtg cataagcgaa cagaacgatc
    14221 tggtgtcagg tcggggagta gtgacgtgag ggtgacgggg tgacggccac ggcggtgccg
    14281 tcgacgatca gcggtgttcg taggacgtga agggcttgtt ccgcgactcg tacgacgcgt
    14341 agcgggcgcc gataagccgg ccctcgtgct cgaagagtgt gtccacctcg tcgtctccct
    14401 cggggaagcg gtggacttcg cgctgccggc ccgtggcgcc gtcgagcacc cgcaggccat
    14461 acgtggaact ggggtcaccg aagaagggcg tctcgcggcg aaaggtgagg accttgatct
    14521 tcccgtcctg gggaatgacg cggtatccgg tgtcgccgtc gaggcggtcg tcgtccacgg
    14581 tgccgcccca gaccggatct ccggtggcca ggtcgaacgc cgtgaggcgg tgagggtcga
    14641 cacggctgtt cctcacccgg tgaaggggca gggcgtagag cctgctgtcg tcggccgccg
    14701 ccgtgagccg tgcggagaac gcgatctcgc cgtacggacc gctgaaaccg atcggcgggt
    14761 tcgggcgccc gttcctgctg aaggagaagt aggccccgga gtcggagtcg cccgaggccg
    14821 aggcggccac gaccaccggg tcggccgaga tgaagtccgc acgggcgtcc caggggacag
    14881 cgctccggtt cccgagcggg gctgaccaca ggagcgcgcc gctggcggga gcgaaggtcg
    14941 cgacgaagag ctcggcgtcg ctcggcacct tgtcacccag gaggtactcg gtgccgccgc
    15001 acgcgaggag ggcggtgacc tggcgctcgg ccatggcagt cgtacccggc acgcagccct
    15061 tgggcagagc cgccttccag cggggcctcc ccgtgcgcac gtccacggcc tgcaggtcgt
    15121 cccctcgaag gagcacggcg atgccgctgc cggcggacac ggtgaaggac tggagacgcg
    15181 acgcccaggt gtcgagggcg ggaaggcggg tctgccagat ctcgcggccg ctgctcatgt
    15241 cgatggcgac gacatcggcg catgccgtgc ccttggccgg ggcggaagtg ccgtccccgt
    15301 cacgggtgag gaccaggacc gagttgtcgg cgtcgtcggc ggcgtggcag accgccgagc
    15361 ggccgggcgg tacgtgcccc caactccgct tgccggtacg gacgtcgtac ccgcgcaccg
    15421 cgtcgaaccg gctgtggacc agagtgtcgc cggacaacca ggccccgttg ccgtgctgct
    15481 cggcctcgcg ctccgcggga gtgtcccagg cgacactcca ttcctcggcg tcggaggagc
    15541 atccggcggt gagtgcgcac agggagaaca ggagcgccac cgtcatggac agggcgcgcc
    15601 tgctccgcct gccggacggc atctcgtgca ccagtgcggc catgtctgcc tcccccgtgc
    15661 gtgtcgcctc gacggtccac aggacctccc gcgttcctcg gcggcgatca tcctagggag
    15721 ccggttcgcc cgggcgaaac ctcgccggag gcggcgtggg cggggcgaag aacggacggg
    15781 cgcctcgtca tcgccagtcc ctacggatca gcatgcgcct ccttgtcggt ggtccctcct
    15841 agagtcagcc aggtccaaga ggtgggggag ggacatgtga cacgggtacc tgagagtcga
    15901 cggaccggac gcgccgctgt gaacgcgctt cgatcgcttc tggagcggca cgatcacatc
    15961 gtgcaggaga tcgatgggca gaacgacttc ggcgaggacc tgcatgtcac cttcagcgag
    16021 agcggccgaa cgacttcgtg gcgtctgctc gcagctatct cgggcgctac aggggcaatc
    16081 atgcgattcg tacgcagctg ggcgagatgg cggacgtcga gttcggccct gctgacgatg
    16141 tcctgcactt cgtcaacgac tgcttcgagg atctgatctt ctggcagcga agaggcgagg
    16201 agtttgccac gctgctccgc agcgacctcg actgggagcc ccgacgcatc acacccgaca
    16261 tgctccgctt cggggccctg gcatccgagt tcgatggaga agagctgccc gagtctctcc
    16321 ggggcctggc cggtgccccg tcgatcggtg acgtgatcct cgacatcgct gaggccatgt
    16381 ggctaggggc atgcttcagc acaaccgagt ggtctcgtcg gccgtcgacc gcccggcgca
    16441 cgggatcgga tcagtcatga gggcgtcccg gcttcgtgcg ccccggtgcg tccaccggca
    16501 ggtgggatgc gcccgcatgt gcccgcatgc gccttccgca gaatgaggcg cactcgacac
    16561 actcggctgg tctgtccgtc tgatggcacc agggggaagc agtggctcga acgcagtcca
    16621 agtgtggagc gctcacgcag aaggggactc ggtgtcagcg ccttgccatg atcggagcat
    16681 cgaggtgtga ccgccaccgt ggtgagtggt cctcgtacga ggtccagaag cgcaaggcga
    16741 agaggaagta gaagcagccg gcaactgggc gactgagcgc agggcgttgg ccgatagccg
    16801 ccggcctctg gaaggcggca gagggaagcc tgctcgatcg ggggccggtg aggggctggc
    16861 cgacgggcgg ctggtgatcg tcaagcaggt caccgacgag ggggacacgg gtgccgacgc
    16921 gagcacgcgc ttcgcgcggg aggtggccgg gctgagcctg gcgggccggg cctccgggcc
    16981 cgctgtggcc ccggcggtgc tcgccacgga cctgccgtcg cgggtgatga ccgagatgtc
    17041 ctagtcgatc gctcccttcg gcatcggccg cggcctggac ctgcttgagg agacgttccc
    17101 aggtaccgtc ggccgaccag aggcggtggc gtttatagac ggtcttccat ggaccgaacc
    17161 gttcgggcac gtcacgccac tgaacccggg tccgcacccg gtgcaggacc ccgtcgatca
    17221 tctgccggtg ctcccgccac ccacaacgcc cgttgctggc cggcaggaat ggccgcagcg
    17281 gttcccactc ggcatcactc agatcacccc gccccatgct ccatcccacg gctggggcat
    17341 accggccgtc acgtgaccgg cacgacaccc tcgcgccggg cgaccttcgg cctggagagg
    17401 agaacccggc gagtcggcag gtcgatttcc gtgacgacga cggtgacctt ctcgccggcc
    17461 tcgaagtctt ccaccagact caccgcaggc cggccggggg cttccctgaa ggggaccagc
    17521 ccggcgatcc cgtccccgag gccgacgatg atgccgaagg gaagcacctt atccaccgtc
    17581 ccgcggagtt cctggcccac cgctgtgcgg tcggcgaatg cctggagggg gtcgggctcc
    17641 catgccctca aggagagtct ggcctccgcg ttgtaggtgt cgaattggag gaactcgcac
    17701 gagacgcgct ggcctacgtg aacgacgtcg gtaggggcgt cgatgtgccg ccaggacagt
    17761 tcggggatga cgatgaaccc gacaccgggg aagagcgggt gggcaggccc gtcgtccagg
    17821 gccacgaaca cgccgaatcg ctcgatcgcc gcaacggtgc cggacaggat gtcgccgctg
    17881 tgcagggacg ccaggaacgc ccagagtccc gggctctcag actgccaatc cataccttca
    17941 ccctggcata cgacatcgag ggccgaccat gacctcgaca gactgaagcc ccatcgtgcc
    18001 ccagtatccg gaaccatgat cggccggaca gggcctagtt ccactgcctg tgcctcaacg
    18061 gtggggctgg acgaactcgg tcagcccggc tgatcgacga agtctgggtg ctgcggtgtc
    18121 cccgcgtacg ggccgttcct ccccgcacgg tggacgtgcg cgacgcagca gcatggctga
    18181 cgcgacgttc agcgtgcgct gctggcctct ttgacggacg atgagaccag agcccgcccg
    18241 ggaagccgtc gcacgttgca ccgggcgggc gcatccattc ttcgcgcagc ctctgatccc
    18301 agaccgaagc cagtccttcc gcactggctc ggcaagcgcc gcagcactcc ccgatggaga
    18361 cgtccagagc tcgtgagcac aaggagcccg ccgggccaga ccggcaacct gctcctccgt
    18421 cccaggaagg gacccctcca gtggcagccc ccggcgctca ggacggctga ccccccggct
    18481 cgtaccagtc atcgatggtg cgaggattca cgccgagtac caggttctcc atggcctgcg
    18541 gcatcggtcc gaattcggcg atccagccct cgacgaggta gatcacgccc acttcgtcga
    18601 tgcctaggaa gaaccggccc tggtcgacct cgccgagcgg gtagagatgg cgcccgatcg
    18661 cttcgcccca ctccatgaac cgttcctcgt cgccccaggc gagttcgggg tccagctcga
    18721 acggcgtgcg cgcacaagtg atcccggggc cgctgacgtg caccgtcaaa ccgccgaact
    18781 cctccaggaa ggtttccgca gcggcatgca tgtcgaggcc gactgaggcg aacatggatc
    18841 gccaacgcgc cgtgtccacc ttccgcccag gcgtccatcc cgacgcttcc aacacgtctt
    18901 ccacctctgc tgaccagctg ctcatctggg gacggactcc ttggcggcta cggggtgaga
    18961 agtgatcctc tcaggggatg tcgctgctgc acagttcggg atcgtgacgt gggatcgttc
    19021 ccgaatcccc gtcgtgaggc acgttcatcc gggccggccg gctgccctgc gccctgcacg
    19081 aaccacggcg gacccgctcg cgacggccgc gccgtccgcc gagctagcgg ggtctggcag
    19141 gagcacacgt gcttcagtgc cgcacgaacg gcagatccgc cggctgcacg ttctcgcgcg
    19201 gccccgctgc tcgcagcacg acgtccagca cgcgcgccgg ggcggccgcg tacgcgtggg
    19261 agaaccacgc catgttggct tccaccacgg cccaccggta gccaggacgg taggtgtcga
    19321 gcagctgtcc gacgtccacg accacggcac tcggcagagc gggctcggcc gcggcgacca
    19381 agcggtcgac gaacgccgcc agctccgcgg cgatcggccc gtgcttgtcg agcggcagag
    19441 gggcgagccg gccgaacacc gcgtaccgac tgcccgtggc gatctgtccg tcgagcagga
    19501 acagccggta ctcggcagcg aaggtcacca catcggagag cagcaccggc gtcgcggggt
    19561 ccaggtcgcc gggcagccgg gagccgtccg cgtagacgtc tgcctcgaag gacttgtccc
    19621 gcggcggctt cacgaacgtc ggacgctcga tcgcccacgc gtccaggacc gtggcggtac
    19681 ggacctcacg cccggtgaac tcctccggca gttcggcaag ccactcatcc gccggctcga
    19741 gcaacgcgaa cccgagcagt ccggccagcc gtgcgcctgc caccggccct ccgtaccagt
    19801 acgcgggtcc cgtcgccgcg gatgcctcct ccgcggcgag gacatccatt ccccgccccg
    19861 ccgcctcggc ggcgagcagc tccatcgtcg acgtccaccg cccaggcatc accagcacgg
    19921 ccatcctcct tcgcttcgta caaagccgcc aggctaggcc cactccctcc cggccgcctt
    19981 cggatttccc gggggcggga ggccgcagaa ccactgcacc gctctgcgcc gaacacccgg
    20041 gccgtctgcc ggcacgggaa tgatcgagga atcgtccggc cgagctctcc gtggttgcgg
    20101 cacgccgtcg gttgtctgct gtcgccgtct gttgcgggag agcattcttc ggcttgaggt
    20161 agaacggcga catggattcc gccgttttgc aacagatgct ggacgaggcc ttcgatcacg
    20221 ccgtcgtgca ccacggatac accaactaca tgcgcgacta cgaggtcatc gtctacgcga
    20281 ctgcggctcc cgacacgggt atccagccgg cctacctgcg ttacctcttc cggtactgcg
    20341 tcgaggcccg ctgtgagaca tccgttccgg ccgcgacgtg gcgggtctcc ctggacgacc
    20401 gtcttgtcga ctacgagacc ggcgctgacc tcgacggata tgtgtggggc gtgaagtggc
    20461 acctcctcta tccgggggcc aagcttctgc ccgagtcaga ggtggccaga cgctggtcgc
    20521 gagccgtcgg catcgacttc cacgacgtac tcatcgagtc caacgcccac cggctcaccc
    20581 tggtcttctc cgaccttcag gtgaccgaag tccccaccgg ctacaccccg ttcgtcacgg
    20641 actgagggag acggagtgag gggggactgg gcccggctgg agtgaacggc tccgctcaga
    20701 gggccgtggc acccgggtag cggcagcggt agcgctagct ggggcggagt tcgccgagta
    20761 cgcgctcgtc cgccccgctc cggctgtatc gcgtgccgcg cgccatgtgc cctctccgtt
    20821 cggcgaagcc cgggccacag ctctgagcga tcggtccaca cgccccccac cgactcgacc
    20881 tagtcggcga gccctgctct caggcaccat gacccggttg ggggtccctg gcggcgcatg
    20941 cgtcgtcggg gaacggtgtt cgggaaccgg gggagtggcc gtgggaaggt tcaggcgcgg
    21001 tgggtcgacg cacgacatgg acgctcaacg gcgcgtgagg cgcagtccgt tgctcttcac
    21061 cgtgccgatc gtgctgctcg tcctgctgac ggcggtgctc ggctgggaag ccgtccgggc
    21121 caacatgtcg gcggcagccc gggccgagtg gccgtggcgc ctgcagttgc tcgacatgga
    21181 gccgctcggc agcctgctcg cggtcgcggc cggtgcggtc ctcgcgaggg ctcagtacgc
    21241 ccgcaccgta cggcctgcgc tcggctggcg cgccgactgg acgaccgggc acctacgggg
    21301 cggcgtaccc gaatggcagg tcggactgct caacggcggc tcccacaccg tcgtgatcga
    21361 ggcctacgag tgccgggccc tgctgcgggg tgaagacccg cagcacgccg ctccgtggac
    21421 cgacgtccag ggcgtcgccg aggtgctcac cggcgccggg ctcaccgtcg gggaggactt
    21481 ccagctggtc accgtcggga gattccccct ggtgggcacc ggctcctacg agacgacgat
    21541 gctcggagcc ttctcccaac gcttcgtcga cgaggtcgag gcgctccaca tccgggtccg
    21601 cgtcagcgat gtcgtcgggg acagccacga gcggactctc gacgccctgc gcggcgcgcg
    21661 ctccaccgcg tatcagcgcc ccgcgccctg accgtccagc caccgcagca cgtcgggcag
    21721 cgcccactga gcggcgaaat gcccggcgtc cggtacgagg acgggctcgg caccggggat
    21781 ccgtcccgcc agccaacggg tgtgcgacac gggcgagaag gcgtcgtcga ggccgtgcca
    21841 cagcagcacg ggcgcggcta cggaggcgac gtcgaagccc cacgggcgga cgaaggccag
    21901 gcagtcgtcg agccagccgt ggtgcgagac ccgcagcgcc tcctggtagg tgcgcagcag
    21961 taccgcccgt acccgagggt cctccacgac cggcaggtca tggggggaga gttcggcccg
    22021 caggtcgtcg aggagacgca ccgggtcccg tcggatggcg tctgcccggg cggccaggtc
    22081 ccgttcgagt ccgccggggt cccgcccgtc cagatgggcg cgggccagac cgtactcgcg
    22141 tacgttgaac ggggtcatgc ccgcgtacca gtccagaccg gccgcgtccg gcggagcgag
    22201 cccgaccagt acgacggcgg cccggacccg atccggtagc agcgccgcgc acgccagcgc
    22261 gtgcggaccc ccgccggacc ggccgaccac cgcgaaccgc tcgacgccga aggcatcggc
    22321 gacggccccc gcgtcgcggg ccgcatcggc gacccggcgg cccggggagc gccgggactc
    22381 cccgtagccg ggacggtcgt aggcgaggaa ccggaagccg gggtgctgct cggcgagtcc
    22441 gggcagcagg gtgccgagcc gggtaccggg cgtcccgtgg aagaggagca ccggggtccc
    22501 cgaggggttg ccccattcct cggccaccag caggcggccg tcgtcggtgc gcacggggag
    22561 tcccatgaga gggagcctag gccgggaagg gggtggtgcg catggccgtc cgtcagcccg
    22621 aatctgcgtg tcaggggtac gtcaggggta cggaggtgtg gacctggcag cggccgagcg
    22681 cggtcccgtg cgacaag
//
