MIBiG Protein Description MIBiG Cluster MiBiG Product % ID % Coverage BLAST Score E-value
ACI88861.1 AlnL_ketoacyl_synthase_alpha BGC0000195.5 PKS:Type II 89.0 100.0 741.0 9.9e-272
ARG41911.1 IstH BGC0001622.5 PKS 81.0 99.0 684.0 1.59e-249
AAC18107.1 ketoacyl_synthase BGC0000225.5 PKS 78.0 100.0 654.0 1.48e-237
BAV16999.1 putative_ketosynthase BGC0001384.5 PKS 77.0 98.8 623.0 3.27e-225
TRO56977.1 beta-ketoacyl-[acyl-carrier-protein]_synthase_family_protein BGC0002361.3 PKS+saccharide 77.0 98.8 623.0 3.65e-225
QBK46637.1 HrsM1 BGC0001960.2 PKS 76.0 99.3 623.0 4.01e-225
AQW35058.1 KS BGC0001675.5 PKS 75.0 97.9 622.0 4.74e-225
MBW8699683.1 Actinorhodin_polyketide_putative_beta-ketoacyl_synthase_1 BGC0002140.2 PKS 76.0 98.8 621.0 2.68e-224
AGO50610.1 ketoacyl_synthase BGC0000229.5 PKS:Type II+saccharide:hybrid/tailoring 77.0 98.8 620.0 7.66e-224
AOZ61212.1 beta-ketoacylsynthase_I BGC0001762.3 other:other 77.0 97.1 617.0 3.37e-223
AAG30189.1 beta-ketoacylsynthase_I BGC0000261.5 PKS 76.0 97.4 617.0 4.51e-223
CAH10117.1 putative_ketoacyl_synthase BGC0000268.5 PKS 77.0 97.9 617.0 5.03e-223
ACX83617.1 keto-acyl_synthase_alpha BGC0000221.5 PKS 75.0 100.2 616.0 2.94e-222
SEG87439.1 act_minimal_PKS_ketosynthase_(KS/KS_alpha) BGC0002712.2 PKS 75.0 98.8 614.0 9.26e-222
AAK06784.1 putative_ketosynthase_SimA1 BGC0001072.5 PKS:Type I+saccharide+other:aminocoumarin 74.0 99.3 613.0 1.8e-221
ARO44655.1 ketoacyl_synthase_alpha_subunit BGC0001769.5 PKS 76.0 97.9 612.0 4.29e-221
ABL09959.1 ketoacyl_synthase BGC0000197.5 PKS:Type II+saccharide:hybrid/tailoring 75.0 99.5 612.0 7.58e-221
AAK57525.1 PgaA BGC0000262.5 PKS:Type II+saccharide:hybrid/tailoring 74.0 99.3 611.0 1.47e-220
AYU66233.1 TjhA1 BGC0002461.2 PKS 75.0 99.5 611.0 1.58e-220
BBA97250.1 putative_beta-ketoacyl_synthase BGC0002383.3 PKS 76.0 98.3 610.0 4.87e-220
AVO00815.1 May16 BGC0001661.5 PKS 76.0 98.8 609.0 8.8e-220
AHA81977.1 Arm7 BGC0000199.5 PKS:Type II+saccharide:hybrid/tailoring 73.0 99.3 608.0 1.71e-219
QDG00826.1 beta-ketoacyl_synthase BGC0002028.4 PKS 74.0 99.3 608.0 1.71e-219
ALJ99855.1 FlsA BGC0001904.2 PKS:Type II aromatic 74.0 98.1 608.0 3.45e-219
UPN68081.1 ketoacyl_synthase BGC0002672.2 PKS 74.0 98.1 608.0 3.57e-219
WP_040253443.1 beta-ketoacyl-[acyl-carrier-protein]_synthase_family_protein BGC0001596.3 PKS:Type II aromatic 74.0 98.8 606.0 2.06e-218
CAJ42320.1 ketoacyl_synthase BGC0000273.5 PKS:Type II+saccharide:hybrid/tailoring 72.0 99.3 605.0 4e-218
CAE17527.1 ketosynthase BGC0000210.5 PKS:Type II+saccharide:oligosaccharide 74.0 99.3 605.0 5.68e-218
OKI81339.1 beta-ACP_synthase BGC0002478.3 PKS 73.0 98.8 605.0 6.11e-218
ADI71443.1 putative_ketosynthase_alpha_subunit BGC0000203.3 PKS 74.0 99.0 604.0 8.06e-218
AFY23044.1 TamM BGC0000274.5 PKS:Type II 73.0 98.8 603.0 1.4e-217
MCG7203820.1 beta-ketoacyl-[acyl-carrier-protein]_synthase_family_protein BGC0000248.5 PKS 73.0 99.3 602.0 4.48e-217
QDQ37910.1 lldA1 BGC0001979.4 PKS 73.0 99.0 602.0 8.7e-217
ARK36155.1 keto-acyl_synthase_alpha BGC0001723.5 PKS 74.0 98.8 602.0 9.71e-217
ACP19353.1 SaqA BGC0000267.5 PKS:Type II+saccharide:oligosaccharide 74.0 98.8 600.0 3.8e-216
OWA25245.1 beta-ACP_synthase BGC0001438.5 PKS+saccharide:hybrid/tailoring 74.0 99.3 600.0 8.34e-216
QOP59270.1 beta-ketoacyl-ACP_synthase BGC0002504.2 PKS 72.0 99.8 596.0 1.26e-214
AKT74262.1 TxnA1 BGC0002141.3 PKS 72.0 99.0 594.0 6.76e-214
AAB36562.1 jadomycin_polyketide_ketosynthase BGC0000234.5 PKS 75.0 99.0 594.0 1.03e-213
CAA09653.1 polyketide_synthase_keto-acyl_synthase BGC0000227.5 PKS:Type II 73.0 99.3 593.0 2e-213
AEE65468.1 ketoacyl_synthase BGC0000223.5 PKS:Type II 73.0 98.6 592.0 6.16e-213
WP_030957354.1 beta-ketoacyl-[acyl-carrier-protein]_synthase_family_protein BGC0001852.4 PKS:Type II+saccharide:hybrid/tailoring 72.0 98.8 590.0 5.62e-212
WP_051729294.1 beta-ketoacyl-[acyl-carrier-protein]_synthase_family_protein BGC0002137.3 PKS 71.0 99.3 590.0 6.49e-212
APR73637.1 beta-ketoacyl_synthase_alpha_subunit BGC0001625.5 PKS 72.0 99.8 588.0 1.39e-211
CBH32809.1 putative_ketoacyl_synthase BGC0000263.5 PKS 72.0 98.8 587.0 5.85e-211
CCH32745.1 Polyketide_ketosynthase BGC0002070.3 PKS 73.0 98.8 587.0 5.85e-211
AAO65346.1 putative_ketoacyl_synthase BGC0000236.5 PKS 73.0 98.8 587.0 6.06e-211
EHM27505.1 ketoacyl_synthase BGC0000235.5 PKS 72.0 99.5 586.0 1.31e-210
POM23762.1 Actinorhodin_polyketide_putative_beta-ketoacyl_synthase_1 BGC0002369.2 PKS 73.0 98.8 585.0 1.78e-210
AHL46686.1 ketosynthase BGC0001177.4 PKS:Type II 70.0 98.8 585.0 2.21e-210
BAC79044.1 ketosynthase_(KS)_alpha_subunit BGC0000245.5 PKS 72.0 99.3 585.0 4.61e-210
AFJ52674.1 ketoacyl_synthase_alpha-subunit BGC0001073.5 NRPS:Type I+PKS 71.0 99.3 585.0 4.61e-210
OKI59862.1 beta-ACP_synthase BGC0002477.3 PKS 72.0 99.5 585.0 5.33e-210
ADE22315.1 putative_polyketide_beta-ketoacyl_synthase_alpha BGC0000279.5 PKS 71.0 99.5 584.0 1.04e-209
BAJ07842.1 putative_ketosynthase BGC0000232.5 PKS 72.0 98.8 583.0 1.37e-209
CAC44200.1 actinorhodin_polyketide_beta-ketoacyl_synthase_alpha_subunit BGC0000194.5 PKS:Type II aromatic 72.0 99.3 585.0 2.33e-209
ADB02843.1 AzicA BGC0000202.5 PKS 70.0 98.1 583.0 2.66e-209
QXL90837.1 polyketide_beta-ketoacyl_synthase_alpha BGC0002426.3 NRPS:Type I 71.0 99.5 582.0 3.64e-209
BAU98041.1 ketosynthase_alpha_subunit BGC0001386.5 PKS 72.0 98.3 582.0 5.35e-209
WP_020275095.1 beta-ketoacyl-[acyl-carrier-protein]_synthase_family_protein BGC0002012.4 PKS 71.0 98.8 582.0 5.55e-209
ctg1_orf7 BGC0001366.5 PKS 71.0 98.8 581.0 1.48e-208
BAL90263.1 putative_beta-ketoacyl_synthase_alpha_subunit BGC0002021.3 PKS 69.0 100.0 579.0 6.21e-208
WP_031147015.1 beta-ketoacyl-[acyl-carrier-protein]_synthase_family_protein BGC0001851.4 PKS:Type II aromatic 71.0 98.8 578.0 1.44e-207
CAA61989.1 ketoacyl_synthase BGC0000247.5 PKS:Type II+saccharide:oligosaccharide 70.0 98.6 577.0 7.2e-207
AMK51281.1 Hex24 BGC0001376.5 PKS 70.0 99.3 576.0 1.02e-206
ACZ87054.1 3-oxoacyl-(acyl-carrier-protein)_synthase_II BGC0002732.3 PKS 70.0 99.3 576.0 1.02e-206
AUI41025.1 putative_polyketide_beta-ketoacyl_synthase_alpha BGC0001512.5 PKS 72.0 97.1 575.0 1.76e-206
MUL41473.1 beta-ketoacyl-[acyl-carrier-protein]_synthase_family_protein BGC0002045.3 PKS:Type II 69.0 98.6 575.0 3.26e-206
ACN64834.1 PokP1 BGC0001061.4 PKS:Type II aromatic 70.0 98.8 574.0 5.88e-206
QLQ36627.1 beta-ketoacyl-[acyl-carrier-protein]_synthase_family_protein BGC0002097.3 NRPS:Type I+PKS:Type II+saccharide:hybrid/tailoring 70.0 99.3 574.0 5.88e-206
WP_037658548.1 beta-ketoacyl-[acyl-carrier-protein]_synthase_family_protein BGC0002000.4 PKS 70.0 98.8 574.0 8.66e-206
QNL10613.1 Beta-ketoacyl_synthase BGC0002514.3 PKS 71.0 98.8 573.0 2.48e-205
QFS19044.1 ketosynthase_alpha_subunit BGC0002506.3 PKS 69.0 99.3 572.0 4.81e-205
AHL46710.1 ketosynthase BGC0001179.5 PKS:Type II 69.0 99.3 572.0 6.82e-205
AKD43514.1 Ketoacyl_synthase BGC0001409.5 PKS 70.0 97.4 571.0 1.15e-204
BAL90284.1 putative_beta-ketoacyl_synthase_alpha_subunit BGC0002021.3 PKS 70.0 98.8 571.0 1.33e-204
QHZ32173.1 polyketide_putative_beta-ketoacyl_synthase BGC0002047.2 PKS 70.0 98.8 571.0 1.43e-204
AUO15560.1 beta-ketoacyl_synthase_alpha BGC0001513.3 PKS 72.0 96.0 570.0 2.46e-204
QTA30604.1 beta-ketoacyl-[acyl-carrier-protein]_synthase_family_protein BGC0002143.2 PKS 68.0 99.8 570.0 2.67e-204
CBH32088.1 putative_ketoacyl_synthase_(KSa) BGC0000211.5 PKS 71.0 98.8 569.0 7.91e-204
QED93112.1 Beta-ketoacyl_synthase_alpha BGC0002556.2 other:other 70.0 100.0 569.0 7.91e-204
AXL88816.1 beta-ACP_synthase BGC0001895.4 PKS 70.0 98.3 566.0 1.13e-202
AAD13536.1 B-ketoacyl-ACP_synthase_homolog BGC0000239.5 PKS:Type II+saccharide:hybrid/tailoring 70.0 101.0 566.0 1.4e-202
QVQ68799.1 mmyP BGC0002129.4 PKS 69.0 99.0 563.0 9.9e-202
CAA54858.1 ketosynthase BGC0000231.5 PKS 68.0 99.3 562.0 4.32e-201
ABM21747.1 PdmA BGC0000256.3 PKS 71.0 99.0 561.0 6.82e-201
AHX24701.1 beta-ketoacyl_synthase_alpha BGC0000200.5 PKS:Type II+saccharide:hybrid/tailoring 69.0 98.8 561.0 8.69e-201
ARD70901.1 beta-ketoacyl_synthase BGC0001693.3 PKS 67.0 99.3 559.0 7.36e-200
AAG03067.1 ketosynthase_alpha_subunit BGC0000266.5 PKS 68.0 98.6 559.0 8.81e-200
AAX57191.1 auricin_polyketide_beta-ketoacyl_synthase_alpha_subunit BGC0000201.5 PKS+saccharide:hybrid/tailoring 68.0 99.3 558.0 1.01e-199
AHZ61892.1 Lom58 BGC0000240.5 PKS:Type II+saccharide:hybrid/tailoring 69.0 98.1 558.0 1.04e-199
CAM34345.1 putative_polyketide_beta-ketoacyl_synthase_alpha BGC0000242.5 PKS 69.0 99.5 558.0 1.84e-199
ADB23391.1 ketosynthase BGC0001062.5 PKS 68.0 98.8 554.0 4.91e-198
AAA67515.1 tetracenomycin_polyketide_synthase_condensing_enzyme BGC0000275.4 PKS:Type II 66.0 99.5 554.0 5.47e-198
ABX71114.1 Lct31 BGC0000238.5 PKS 67.0 99.3 554.0 6.48e-198
ABP54674.1 beta-ketoacyl_synthase BGC0000241.5 PKS:Type II+saccharide:hybrid/tailoring 68.0 98.1 553.0 9.89e-198
ADE34518.1 SsfA BGC0000269.5 PKS:Type II+saccharide:hybrid/tailoring 67.0 99.5 553.0 2.06e-197
ABX71148.1 Lcz31 BGC0000237.5 PKS 67.0 99.3 552.0 2.63e-197
AAP85362.1 putative_keto_synthase_alpha BGC0000233.5 PKS 69.0 98.1 551.0 5.49e-197
AMX23327.1 putative_beta-ketoacyl_synthase_alpha BGC0001500.3 PKS 68.0 99.5 551.0 5.9e-197
AAZ78325.1 OxyA BGC0000254.5 PKS 68.0 99.5 551.0 8.67e-197
AHD25926.1 putative_keto-acyl_synthase_alpha BGC0000208.5 PKS 68.0 97.9 550.0 2.24e-196
ABC00726.1 CosB BGC0000214.5 PKS 68.0 100.0 549.0 4.48e-196
KDN80064.1 beta-ACP_synthase BGC0001074.5 saccharide+PKS 68.0 100.0 549.0 4.48e-196
BAJ52681.1 putative_ketoacyl_synthase BGC0000222.5 PKS 68.0 97.4 549.0 4.64e-196
ADG86315.1 ketosynthase BGC0000190.5 PKS 66.0 98.6 548.0 1.24e-195
QED90637.1 beta-ketoacyl-[acyl-carrier-protein]_synthase_family_protein BGC0002081.3 PKS 67.0 100.2 546.0 7.64e-195
ABW11825.1 Beta-ketoacyl_synthase BGC0001197.5 PKS 67.0 100.2 546.0 1.41e-194
AAF81728.1 putative_keto_synthase_alpha_EncA BGC0000220.4 PKS:Type II 65.0 100.0 545.0 3.1e-194
AAA65206.1 daunorubicin-doxorubicin_polyketide_synthase BGC0000218.5 PKS 67.0 99.3 544.0 3.81e-194
WP_017947381.1 beta-ketoacyl-[acyl-carrier-protein]_synthase_family_protein BGC0001558.5 PKS 68.0 99.3 544.0 4.24e-194
ATJ00755.1 beta-ACP_synthase BGC0001568.5 PKS 68.0 99.3 544.0 4.24e-194
AFU65894.1 DacA BGC0000216.5 PKS 67.0 98.1 543.0 1.4e-193
QIC03940.1 EncA BGC0002366.2 PKS 64.0 100.0 543.0 3.26e-193
AAQ08916.1 3-ketoacyl-ACP_synthase BGC0000224.4 PKS:Type II 64.0 98.6 538.0 7.79e-192
CAA44380.1 beta-ketoacyl_synthase BGC0000215.5 PKS 66.0 98.6 538.0 1.14e-191
EDY42532.1 tetracenomycin_C_polyketide_beta-ketoacyl_synthase_1 BGC0000212.5 PKS:Type II 65.0 99.5 538.0 1.23e-191
AEI98666.1 CtcW BGC0000209.5 PKS 67.0 99.5 538.0 1.37e-191
QKO28696.1 beta-ketoacyl_synthase BGC0002315.2 PKS 66.0 98.6 535.0 3.08e-190
BAB72045.1 AknB BGC0000191.5 PKS 65.0 99.5 533.0 7.9e-190
AAF70106.1 AknB BGC0000192.3 PKS 65.0 99.5 531.0 6.45e-189
BBE36466.1 beta-ketoacyl_synthase BGC0001922.4 PKS 64.0 99.0 528.0 6.47e-188
WP_029025958.1 beta-ketoacyl-[acyl-carrier-protein]_synthase_family_protein BGC0000198.5 PKS:Type II+saccharide:hybrid/tailoring 65.0 99.8 528.0 1.45e-187
CAM58798.1 BenA_protein BGC0000204.5 PKS:Type II 66.0 97.9 528.0 1.5e-187
AAA87618.1 polyketide_synthase BGC0000217.5 PKS 65.0 99.3 523.0 1.19e-185
CAP12600.1 ketoacyl_synthase_alpha BGC0000219.4 PKS:Type II+saccharide:hybrid/tailoring 65.0 98.8 521.0 8.15e-185
BAB69165.1 3-oxoacyl-(acyl_carrier_protein)_synthase_I BGC0000271.5 PKS 63.0 99.3 520.0 1.53e-184
AQP25565.1 KSA_protein BGC0001590.5 PKS:Type II aromatic 64.0 99.3 518.0 1.2e-183
CAG14965.1 keto-acyl_synthase_alpha BGC0000253.4 PKS:Type II 73.0 85.7 514.0 5.44e-183
AAG26879.1 PKSA_beta-ketoacylsynthase_subunit_alpha BGC0000272.3 PKS 64.0 99.3 515.0 1.05e-182
OWA01596.1 beta-ACP_synthase BGC0001439.5 PKS+saccharide:hybrid/tailoring 64.0 98.1 515.0 1.21e-182
AAP69573.1 putative_alpha-ketoacyl_synthase BGC0000226.5 PKS 63.0 99.5 482.0 1.53e-169
AXM42927.1 beta-ketoacyl_synthase_alpha BGC0001940.3 PKS 51.0 99.0 397.0 6.03e-136
CAE51174.1 RemA_protein BGC0000264.5 PKS:Type II 43.0 101.4 329.0 2.37e-109
QEF99667.1 3-oxoacyl-[acyl-carrier-protein]_synthase_2 BGC0002080.3 other:trna-derived 40.0 98.8 292.0 3.69e-95
ACC80690.1 beta-ketoacyl_synthase BGC0002711.2 PKS 40.0 99.5 288.0 1.67e-93
CAE16563.1 BGC0000196.4 PKS:Type II 39.0 98.3 285.0 4.46e-92
WP_016467648.1 beta-ketoacyl-[acyl-carrier-protein]_synthase_family_protein BGC0002381.3 other:other+PKS 40.0 98.8 266.0 6.2e-85
AHA12083.1 3-oxoacyl-acyl_carrier_protein_synthase BGC0001172.5 NRPS:Type I+PKS:Type I 39.0 98.6 250.0 8.61e-79
MBA5221213.1 beta-ketoacyl-[acyl-carrier-protein]_synthase_family_protein BGC0002090.3 PKS:Type I+NRPS:Type I 38.0 99.5 244.0 1.03e-76
CAL48955.1 beta-ketoacyl-ACP_synthase_II BGC0001343.3 PKS 39.0 99.5 244.0 1.63e-76
QTC09981.1 beta-ketoacyl-[acyl-carrier-protein]_synthase_family_protein BGC0002372.3 PKS+terpene+other:other 36.0 103.1 221.0 1.45e-67
QMX85615.1 SapH BGC0002510.2 PKS 40.0 100.0 220.0 1.69e-67
EDT06076.1 3-oxoacyl-(acyl-carrier-protein)_synthase_2 BGC0001897.4 PKS 37.0 101.9 220.0 3.51e-67
QRG35024.1 beta-ketoacyl-[acyl-carrier-protein]_synthase_family_protein BGC0002378.3 NRPS:Type I 40.0 100.0 219.0 4.69e-67
AFV52176.1 ketosynthase BGC0000081.5 NRPS:Type I+PKS:Iterative type I 38.0 98.6 218.0 1.79e-66
AXM42928.1 beta-ketoacyl_synthase_beta BGC0001940.3 PKS 33.0 98.8 218.0 2.45e-66
BAX64252.1 ketosynthase BGC0001623.4 NRPS:Type I+PKS 37.0 98.8 216.0 6.13e-66
AEU17885.1 3-oxo-ACP_synthase_II BGC0001072.5 PKS:Type I+saccharide+other:aminocoumarin 36.0 99.5 216.0 1.34e-65
PVC99861.1 3-oxoacyl-ACP_synthase BGC0002100.2 NRPS:Type I+other:other 35.0 100.2 213.0 1.89e-64
BBC20648.1 beta-ketoacyl_synthase BGC0001917.4 PKS 35.0 102.1 212.0 5.91e-64
WP_054234622.1 beta-ketoacyl-[acyl-carrier-protein]_synthase_family_protein BGC0002014.3 NRPS:Type I+PKS 36.0 100.5 209.0 6.11e-63
BCN28630.1 3-oxoacyl-ACP_synthase BGC0002441.2 PKS+NRPS:Type I 34.0 98.8 206.0 7.15e-62
BAB72046.1 AknC BGC0000191.5 PKS 34.0 99.5 205.0 1.56e-61
QHZ32174.1 polyketide_putative_beta-ketoacyl_synthase_2 BGC0002047.2 PKS 34.0 98.1 203.0 4.47e-61
ABX71149.1 Lcz32 BGC0000237.5 PKS 36.0 98.8 203.0 5.92e-61
AIL50179.1 putative_type_II_PKS_ketosynthase_alpha_subunit BGC0000213.4 PKS:Type II 35.0 100.5 203.0 6.61e-61
QNH67535.1 Cip7 BGC0002108.3 NRPS:Type I 34.0 98.1 203.0 8.4e-61
AAW85355.1 3-oxoacyl-(acyl_carrier_protein)_synthase BGC0000837.4 other:other 33.0 99.8 202.0 1.85e-60
AAN79648.1 Putative_beta-ketoacyl-ACP_synthase BGC0000836.5 other:other 34.0 100.0 202.0 2.48e-60
CAM58799.1 BenB_protein BGC0000204.5 PKS:Type II 34.0 97.6 201.0 3.47e-60
ADI58650.1 AsuC13 BGC0000187.5 PKS:Type II 35.0 98.6 198.0 3.49e-59
QED88051.1 3-oxoacyl-ACP_synthase_alpha BGC0001967.4 NRPS:Type I+PKS 34.0 99.0 198.0 6.83e-59
ABX71115.1 Lct32 BGC0000238.5 PKS 34.0 98.8 196.0 3.69e-58
AAF70107.1 AknC BGC0000192.3 PKS 33.0 99.5 195.0 7.43e-58
AIL50166.1 putative_beta-ketoacyl_synthase BGC0000213.4 PKS:Type II 37.0 99.3 194.0 1.29e-57
QBG38767.1 Atr6 BGC0001975.4 NRPS:Type I 33.0 98.6 194.0 2e-57
WP_054234628.1 beta-ketoacyl-[acyl-carrier-protein]_synthase_family_protein BGC0002014.3 NRPS:Type I+PKS 32.0 99.8 193.0 4.12e-57
ALG65306.1 Cal30 BGC0001297.4 NRPS:Type I 34.0 100.7 193.0 7.01e-57
BAV17000.1 putative_chain_length_determinant_factor BGC0001384.5 PKS 36.0 98.3 192.0 9.36e-57
QBA57748.1 3-oxoacyl-ACP_synthase BGC0002377.2 NRPS:Type I 32.0 100.0 192.0 1.03e-56
QKO28695.1 beta-ketoacyl_synthase BGC0002315.2 PKS 35.0 99.0 192.0 1.88e-56
AEA30260.1 putative_3-oxoacyl-ACP_synthase_II BGC0000429.4 NRPS:Type I+PKS 34.0 99.5 192.0 2.02e-56
QYA95693.1 beta-ketoacyl-[acyl-carrier-protein]_synthase_family_protein BGC0002676.2 NRPS:Type I 34.0 99.5 192.0 2.02e-56
ABW11826.1 Beta-ketoacyl_synthase BGC0001197.5 PKS 34.0 97.9 192.0 2.56e-56
QHB92589.1 YsfB BGC0002547.2 PKS 36.0 101.0 191.0 2.77e-56
WP_031147017.1 ketosynthase_chain-length_factor BGC0001851.4 PKS:Type II aromatic 35.0 100.5 189.0 1.15e-55
CAP12601.1 ketoacyl_synthase_beta BGC0000219.4 PKS:Type II+saccharide:hybrid/tailoring 34.0 98.1 189.0 1.29e-55
WP_045972733.1 beta-ketoacyl-ACP_synthase BGC0002008.3 other:other 34.0 99.0 187.0 1.65e-54
AHA81978.1 Arm8 BGC0000199.5 PKS:Type II+saccharide:hybrid/tailoring 34.0 98.6 186.0 3.41e-54
QDJ74257.1 3-oxoacyl-ACP_synthase BGC0002109.3 NRPS:Type I 33.0 98.8 184.0 1.08e-53
AFU65895.1 DacB BGC0000216.5 PKS 33.0 98.1 182.0 6.41e-53
CBH32089.1 putative_chain_length_factor_(KSa) BGC0000211.5 PKS 33.0 99.0 181.0 2.4e-52
AAG26880.1 PKSA_beta-ketoacylsynthase_subunit_beta BGC0000272.3 PKS 33.0 99.3 181.0 2.42e-52
CAJ42319.1 chain_length_factor BGC0000273.5 PKS:Type II+saccharide:hybrid/tailoring 34.0 98.6 181.0 2.63e-52
AAG03068.1 ketosynthase_beta_subunit BGC0000266.5 PKS 32.0 99.3 181.0 3.79e-52
EDY42531.1 tetracenomycin_C_polyketide_beta-ketoacyl_synthase_2 BGC0000212.5 PKS:Type II 32.0 98.8 180.0 4.23e-52
UPN68082.1 chain_length_factor BGC0002672.2 PKS 33.0 99.5 180.0 4.92e-52
MBW8699684.1 Actinorhodin_polyketide_putative_beta-ketoacyl_synthase_2 BGC0002140.2 PKS 34.0 99.8 179.0 1.06e-51
ARO44656.1 ketoacyl_synthase_CLF BGC0001769.5 PKS 34.0 99.8 179.0 1.48e-51
AAQ08917.1 chain_length_factor BGC0000224.4 PKS:Type II 33.0 98.3 177.0 3.6e-51
WP_030957356.1 ketosynthase_chain-length_factor BGC0001852.4 PKS:Type II+saccharide:hybrid/tailoring 34.0 100.5 177.0 5.39e-51
BCN28644.1 3-oxoacyl-ACP_synthase BGC0002441.2 PKS+NRPS:Type I 35.0 85.3 176.0 1.12e-50
AQP25564.1 KSB_protein BGC0001590.5 PKS:Type II aromatic 33.0 99.5 176.0 1.29e-50
AGO50611.1 chain_length_determinant BGC0000229.5 PKS:Type II+saccharide:hybrid/tailoring 32.0 98.3 175.0 2.88e-50
QBK46636.1 HrsM2 BGC0001960.2 PKS 32.0 99.5 175.0 3.22e-50
OKI59861.1 beta-ketoacyl_synthase BGC0002477.3 PKS 32.0 100.5 173.0 1.53e-49
EHM27506.1 chain_length_determinant_protein BGC0000235.5 PKS 32.0 100.5 172.0 2.99e-49
MCG7203819.1 ketosynthase_chain-length_factor BGC0000248.5 PKS 31.0 98.8 172.0 6.88e-49
BAJ07844.1 putative_chain_length_determinant_factor BGC0000232.5 PKS 33.0 100.5 171.0 7.8e-49
WP_037817208.1 ketosynthase_chain-length_factor BGC0002137.3 PKS 32.0 96.9 171.0 1.02e-48
ACH85583.1 putative_3-oxoacyl-ACP_synthase BGC0000283.4 other:cyclitol 32.0 99.8 168.0 1.44e-47
TRO56978.1 ketosynthase_chain-length_factor BGC0002361.3 PKS+saccharide 32.0 98.6 168.0 1.71e-47
AHD25927.1 putative_keto-acyl_synthase_beta BGC0000208.5 PKS 30.0 97.9 167.0 2.96e-47
CAH10116.1 putative_chain_length_factor BGC0000268.5 PKS 32.0 98.6 167.0 3.34e-47
AJS09384.1 Ketoacyl-acyl_carrier_protein_synthase_II BGC0001150.5 PKS:Type II 31.0 102.6 166.0 1.93e-46
ctg1_orf8 BGC0001366.5 PKS 31.0 101.0 164.0 6.93e-46
AAA65207.1 daunorubicin-doxorubicin_polyketide_synthase BGC0000218.5 PKS 31.0 98.1 162.0 2.56e-45
BAC79045.1 ketosynthase_(KS)_beta_subunit BGC0000245.5 PKS 30.0 100.2 160.0 9.47e-45
ADE22314.1 putative_polyketide_beta-ketoacyl_synthase_beta BGC0000279.5 PKS 31.0 102.1 161.0 1.02e-44
ABC42547.1 putative_beta-ketoacyl_synthase_1 BGC0000698.5 saccharide 32.0 99.8 158.0 5.11e-44
BAL90285.1 putative_beta-ketoacyl_synthase_beta_subunit BGC0002021.3 PKS 32.0 97.9 157.0 1.11e-43
AAZ78326.1 OxyB BGC0000254.5 PKS 31.0 98.8 157.0 3.42e-43
ADG86316.1 chain_length_factor BGC0000190.5 PKS 31.0 99.8 156.0 6.75e-43
ARG41912.1 IstI BGC0001622.5 PKS 30.0 98.1 156.0 8.64e-43
CAC44201.1 actinorhodin_polyketide_beta-ketoacyl_synthase_beta_subunit BGC0000194.5 PKS:Type II aromatic 29.0 98.8 154.0 2.56e-42
WP_018891747.1 ketosynthase_chain-length_factor BGC0001558.5 PKS 30.0 97.6 152.0 2.12e-41
ATJ00754.1 beta-ketoacyl_synthase BGC0001568.5 PKS 30.0 97.6 152.0 2.12e-41
AUO15561.1 beta-ketoacyl_synthase_beta BGC0001513.3 PKS 29.0 99.5 151.0 3.3e-41
CAA09654.1 polyketide_synthase_chain_length_factor BGC0000227.5 PKS:Type II 29.0 100.0 151.0 4.17e-41
ABC00728.1 CosC BGC0000214.5 PKS 30.0 97.4 148.0 4.07e-40
KDN80065.1 beta-ketoacyl_synthase BGC0001074.5 saccharide+PKS 30.0 97.4 148.0 4.07e-40
AAA87619.1 polyketide_synthase BGC0000217.5 PKS 31.0 98.1 148.0 4.16e-40
ADQ74619.1 beta-ketoacyl_synthase BGC0000921.5 other:shikimate-derived+PKS+NRPS:Type I 36.0 61.3 143.0 2.13e-38
ABF92774.1 polyketide_synthase BGC0001025.5 NRPS:Type I+PKS:Trans-AT type I 28.0 101.4 133.0 1.38e-34
AAG13917.1 megalomicin_6-deoxyerythronolide_B_synthase_1 BGC0000092.5 PKS 30.0 94.8 132.0 8.1e-33
RLV64599.1 Erythronolide_synthase,_modules_1_and_2 BGC0001845.2 other:aminocoumarin+PKS+NRPS:Type I 29.0 95.0 128.0 1.55e-31
AZF85946.1 type_I_polyketide_synthase BGC0001963.2 PKS:Type I 29.0 96.2 125.0 1.34e-30
AAG13919.1 megalomicin_6-deoxyerythronolide_B_synthase_3 BGC0000092.5 PKS 31.0 93.1 124.0 3.08e-30
CCE88376.1 polyketide_synthase BGC0001034.5 NRPS:Type I+PKS:Type I 27.0 97.4 124.0 3.15e-30
ABB05102.1 LipPks1 BGC0001003.5 NRPS:Type I+PKS:Type I+saccharide:hybrid/tailoring 29.0 96.0 122.0 1.74e-29
AXN93610.1 PuwB BGC0001953.4 NRPS:Type I 27.0 106.4 122.0 2.39e-29
BAC76493.1 lankamycin_synthase_LkmAI BGC0000085.5 PKS 30.0 98.3 121.0 3.35e-29
ASX95227.1 IlaE BGC0001620.5 NRPS:Type I+PKS 28.0 92.4 121.0 3.43e-29
WP_048832936.1 type_I_polyketide_synthase BGC0001348.5 PKS:Type I 29.0 95.2 121.0 3.44e-29
WP_019634550.1 type_I_polyketide_synthase BGC0001443.5 NRPS:Type I+PKS 29.0 93.8 120.0 5.27e-29
AAU93807.2 polyketide_synthase_modules_1_and_2 BGC0000054.5 PKS 31.0 79.3 120.0 6.04e-29
BBA20952.1 type_I_polyketide_synthase BGC0001763.5 NRPS:Type I+PKS 28.0 92.4 120.0 6.2e-29
ADC79616.1 BafAI BGC0000028.5 PKS:Type I 30.0 95.2 120.0 1.12e-28
CAM00065.1 EryAIII_Erythromycin_polyketide_synthase_modules_5_and_6 BGC0000055.5 PKS:Type I+saccharide:hybrid/tailoring 30.0 92.9 119.0 1.45e-28
AZF85917.1 type_I_polyketide_synthase BGC0001963.2 PKS:Type I 31.0 81.2 119.0 1.46e-28
CAM00062.1 EryAI_Erythromycin_polyketide_synthase_modules_1_and_2 BGC0000055.5 PKS:Type I+saccharide:hybrid/tailoring 29.0 94.8 119.0 1.47e-28
UHY14130.1 PKS_I BGC0002671.2 PKS 31.0 79.3 119.0 2.35e-28
AAK57186.1 MxaB2 BGC0001022.5 NRPS:Type I+PKS 26.0 101.4 118.0 2.58e-28
AHE80992.1 PieA2 BGC0001169.5 PKS:Type I 30.0 76.0 119.0 2.64e-28
AGY62755.1 EbeC BGC0000051.5 PKS 30.0 95.2 118.0 3.13e-28
SCN11951.1 ebeC-type_I_polyketide_synthase BGC0001580.3 PKS 30.0 95.2 118.0 3.51e-28
AAZ77693.1 ChlA1 BGC0000036.5 PKS:Type I+saccharide:oligosaccharide 29.0 96.0 118.0 3.66e-28
CAD17792.1 probable_non_ribosomal_peptide_synthetase_protein BGC0001363.5 NRPS:Type I+PKS 27.0 94.5 118.0 3.74e-28
AXN93597.1 PuwB BGC0001952.3 NRPS:Type I 27.0 105.9 117.0 6.19e-28
CCA89326.1 mixed_trans-AT_type_I_polyketide_synthase/nonribosomal_peptide_synthetase BGC0001111.5 NRPS:Type I+PKS:Trans-AT type I 28.0 101.2 117.0 6.9e-28
ANZ22987.1 ZinD BGC0001828.5 PKS 30.0 78.9 117.0 8.57e-28
CAE45672.1 Borrelidin_polyketide_synthase,_type_I BGC0000031.5 PKS:Type I 29.0 94.5 117.0 1.04e-27
ALV82335.1 borrelidin_type_I_polyketide_synthase BGC0001533.5 PKS 29.0 94.5 117.0 1.04e-27
AHA38203.1 GphJ BGC0000069.5 PKS 26.0 95.5 117.0 1.05e-27
BAW35655.1 modular_polyketide_synthase BGC0002355.2 PKS+other:other 31.0 79.3 116.0 1.61e-27
AIJ04685.1 polyketide_synthase BGC0001383.3 PKS 25.0 103.8 116.0 2.01e-27
AMB20394.1 polyketide_synthase BGC0002072.3 PKS:Type I 28.0 96.0 116.0 2.17e-27
CBW54671.1 polyketide_synthase/non_ribosomal_peptide_synthetase BGC0000971.5 NRPS:Type I+PKS:Type I 29.0 92.6 115.0 2.62e-27
AEZ54375.1 PieA2 BGC0000124.5 PKS 29.0 92.6 115.0 5.07e-27
WP_013310341.1 aminotransferase_class_III-fold_pyridoxal_phosphate-dependent_enzyme BGC0001728.4 NRPS:Type I+PKS 29.0 86.7 114.0 6.34e-27
AAZ94388.1 nodular_polyketide_synthase BGC0000040.5 PKS 30.0 78.9 114.0 7.03e-27
CAQ52626.1 type_I_polyketide_synthase,_loading_module_and_modules_1-3 BGC0001066.5 PKS:Type I 29.0 80.3 114.0 7.12e-27
AAO62584.1 polyketide_synthase_type_1 BGC0001016.5 NRPS:Type I+PKS 25.0 96.7 114.0 9.26e-27
AAX98188.1 polyketide_synthase_type_I BGC0000052.5 PKS 28.0 96.4 114.0 9.47e-27
AXN93577.1 PuwB BGC0001950.4 NRPS:Type I 26.0 105.7 114.0 1.19e-26
AXN93586.1 PuwB BGC0001951.4 NRPS:Type I 26.0 105.7 114.0 1.19e-26
CAG23969.1 polyketide_synthase_type_I BGC0000181.5 PKS 24.0 103.8 113.0 1.58e-26
QLD23835.2 SDR_family_NAD(P)-dependent_oxidoreductase BGC0002086.3 PKS 27.0 91.9 113.0 1.69e-26
WP_037611838.1 polyketide_synthase BGC0002381.3 other:other+PKS 27.0 101.4 112.0 2.23e-26
AZF85945.1 type_I_polyketide_synthase BGC0001963.2 PKS:Type I 31.0 78.9 112.0 3.07e-26
AGY62756.1 EbeD BGC0000051.5 PKS 26.0 95.2 112.0 3.28e-26
ABW96542.1 type_I_modular_polyketide_synthase BGC0000159.5 PKS:Type I 28.0 95.5 112.0 4.27e-26
SCN11952.1 ebeD-type_I_polyketide_synthase BGC0001580.3 PKS 26.0 95.2 112.0 5.43e-26
ARW71483.1 type_I_PKS_loading_module,_module_1,_module_2 BGC0001812.3 PKS 27.0 91.9 110.0 1.33e-25
QCP68972.1 VatE BGC0002296.2 NRPS:Type I+PKS 26.0 106.9 110.0 2.1e-25
PLB34720.1 polyketide_synthase BGC0002749.2 NRPS:Type VI+PKS:Type I 26.0 96.4 110.0 2.24e-25
ADC79617.1 BafAII BGC0000028.5 PKS:Type I 30.0 79.1 110.0 2.41e-25
AIW82279.1 PuwB BGC0001125.5 NRPS:Type I+PKS 26.0 105.7 109.0 3.02e-25
QDG75024.1 trans-_AT_polyketide_synthase_type_I BGC0002068.3 NRPS:Type I+PKS 28.0 103.8 109.0 3.2e-25
BCB17029.1 modular_polyketide_synthase BGC0002523.2 NRPS:Type I 29.0 94.5 109.0 3.22e-25
ATP76241.1 NdaD BGC0001705.4 NRPS:Type I+PKS 25.0 96.7 109.0 4.25e-25
QDG75035.1 mixed_type_I_polyketide_synthase_-_peptide_synthetase BGC0002068.3 NRPS:Type I+PKS 26.0 94.8 109.0 4.44e-25
QCX41916.1 Mhr10 BGC0001956.3 PKS 27.0 89.5 107.0 1.04e-24
QHD26313.1 polyketide_synthase BGC0002479.3 PKS+NRPS:Type I+saccharide 27.0 89.5 107.0 1.04e-24
ACR12418.1 modular_polyketide_synthase,_type_I_PKS BGC0000185.5 PKS:Type I 29.0 65.6 108.0 1.04e-24
AAS98777.1 JamE BGC0001001.5 NRPS:Type I+PKS 26.0 107.8 107.0 1.64e-24
KYC42746.1 beta-ketoacyl_synthase BGC0002484.3 NRPS:Type I+PKS 28.0 106.9 105.0 2.27e-24
AGC45619.1 polyketide_synthase BGC0001394.5 NRPS:Type I+PKS 25.0 96.0 107.0 2.29e-24
AAU93805.2 polyketide_synthase_modules_5_and_6 BGC0000054.5 PKS 28.0 94.1 107.0 2.42e-24
AQW44890.1 polyketide_synthase BGC0001737.3 NRPS:Type I+PKS 26.0 96.0 106.0 3.07e-24
AAQ84156.1 Plm1 BGC0000123.5 PKS 27.0 96.0 106.0 3.14e-24
ADF88276.1 polyketide_synthase BGC0000981.3 NRPS:Type I+PKS 27.0 96.4 106.0 4.01e-24
MBO1318656.1 amino_acid_adenylation_domain-containing_protein BGC0002815.2 NRPS:Type I+PKS:Modular type I 27.0 96.0 106.0 4.32e-24
AIW82282.1 PuwE BGC0001125.5 NRPS:Type I+PKS 26.0 96.4 105.0 5.8e-24
TXJ86097.1 SDR_family_NAD(P)-dependent_oxidoreductase BGC0002789.2 PKS:Modular type I 27.0 96.9 105.0 5.86e-24
IF55_RS40995 beta-ketoacyl_synthase_N-terminal-like_domain-containing_protein BGC0001348.5 PKS:Type I 27.0 96.0 105.0 6.2e-24
ADH04659.1 TugC BGC0001342.3 NRPS:Type I+PKS 25.0 96.9 105.0 7.87e-24
BAP34763.1 type_I_polyketide_synthase BGC0000078.5 PKS 27.0 96.0 105.0 7.96e-24
QWF78548.1 3-ketoacyl-CoA_thiolase BGC0002142.2 PKS 26.0 102.6 105.0 8.06e-24
AAF00958.1 McyE BGC0001017.5 NRPS:Type I+PKS:Type I 24.0 93.3 105.0 1.06e-23
CAA16487.1 polyketide_synthase_RedX BGC0001063.5 NRPS:Type I+PKS 29.0 60.1 104.0 1.06e-23
ABX60152.1 polyketide_synthase BGC0000978.5 NRPS:Type I+PKS:Type I+other:other 27.0 96.4 104.0 1.74e-23
AXN93580.1 PuwE BGC0001950.4 NRPS:Type I 25.0 96.4 104.0 1.87e-23
AXN93589.1 PuwE BGC0001951.4 NRPS:Type I 25.0 96.4 104.0 1.87e-23
ATP76239.1 NdaF BGC0001705.4 NRPS:Type I+PKS 24.0 93.3 104.0 1.89e-23
SCO70308.1 Type_I_polyketide_synthase BGC0001433.5 PKS:Type I 28.0 92.9 104.0 1.94e-23
ADM46358.1 polyketide_synthase BGC0000106.5 PKS 29.0 96.0 104.0 1.96e-23
QSJ20136.1 polyketide_synthase BGC0002572.3 NRPS:Type I+PKS 28.0 106.9 102.0 2.54e-23
QVV57685.1 malonyl_CoA-acyl_carrier_protein_transacylase BGC0002338.3 PKS 28.0 78.6 103.0 3.12e-23
MBA5221205.1 polyketide_synthase BGC0002090.3 PKS:Type I+NRPS:Type I 30.0 62.2 102.0 4.74e-23
AXN93613.1 PuwE BGC0001953.4 NRPS:Type I 25.0 96.2 102.0 6.02e-23
AIT55263.1 GulF BGC0000072.5 PKS:Type I 26.0 95.7 102.0 7.81e-23
ADN68482.1 SorG BGC0000184.5 PKS:Trans-AT type I 24.0 105.0 102.0 7.93e-23
AAO62582.1 polyketide_synthase_peptide_sythetase_fusion_protein BGC0001016.5 NRPS:Type I+PKS 24.0 93.3 102.0 1.09e-22
OEI73462.1 hypothetical_protein BGC0001520.3 PKS 25.0 93.3 100.0 2.69e-22
ABC84456.1 NigAI BGC0000114.5 PKS:Type I 27.0 98.6 100.0 3.36e-22
AQW44870.1 polyketide_synthase BGC0001761.3 PKS 26.0 108.8 99.0 1.12e-21
BCB17032.1 modular_polyketide_synthase BGC0002523.2 NRPS:Type I 27.0 92.9 99.0 1.16e-21
AXN93601.1 PuwE BGC0001952.3 NRPS:Type I 25.0 96.2 99.0 1.49e-21
DAC80061.1 PKS BGC0001836.3 PKS:Trans-AT type I 27.0 96.2 98.0 2.74e-21
AZH23821.1 MgiH BGC0001971.3 NRPS:Type I+PKS 26.0 86.2 97.0 3.23e-21
DAC80077.1 PKS BGC0001835.2 PKS 26.0 82.7 97.0 3.75e-21
ACC40923.1 polyketide_synthase_Pks9 BGC0001665.3 PKS 25.0 88.8 97.0 4.98e-21
CAD29794.1 peptide_synthetase BGC0001015.5 NRPS:Type I+PKS 23.0 93.3 97.0 6.42e-21
AKA59088.1 type-I_PKS BGC0001619.5 PKS 25.0 96.0 96.0 1.16e-20
ABV83221.1 CppI BGC0000116.5 PKS 26.0 79.1 96.0 1.21e-20
QCX41945.1 Amc8 BGC0001957.4 PKS 25.0 88.8 95.0 1.57e-20
QHW08554.1 polyketide_synthase BGC0002054.2 PKS+NRPS:Type I+saccharide 25.0 88.8 95.0 1.57e-20
CAQ34917.1 polyketide_synthase BGC0000986.5 NRPS:Type I+PKS 26.0 94.5 95.0 1.78e-20
AZH23791.1 MgcH BGC0001970.3 NRPS:Type I+PKS 26.0 86.2 95.0 2.46e-20
UWK15753.1 LasM BGC0002153.2 PKS 27.0 80.0 94.0 6.84e-20
ADA82581.1 trans-AT_polyketide_synthase BGC0001110.5 NRPS:Type I+PKS:Trans-AT type I 23.0 96.9 92.0 2.75e-19
QZA73305.1 type_I_polyketide_synthase BGC0002385.3 PKS 26.0 92.9 92.0 2.9e-19
AEC04363.1 polyketide_synthase BGC0000178.5 PKS:Trans-AT type I 25.0 77.2 91.0 6.69e-19
AEE88279.1 CurK BGC0000976.5 NRPS:Type I+PKS:Type I 23.0 96.9 90.0 8.3e-19
AAT70106.1 CurK BGC0001165.5 NRPS:Type I+PKS:Type I 23.0 96.9 90.0 8.3e-19
ACR13997.1 modular_polyketide_synthase,_type_I_PKS BGC0000185.5 PKS:Type I 26.0 90.5 88.0 3.77e-18
UWK15755.1 LasO BGC0002153.2 PKS 26.0 93.3 88.0 3.91e-18
RAT98529.1 trans-acyltransferase_polyketide_synthase BGC0001470.5 PKS:Trans-AT type I 28.0 56.8 84.0 6.45e-17
BCP96883.1 non-reducing_polyketide_synthase BGC0002614.2 NRPS:Type I+PKS 26.0 76.2 82.0 2.57e-16
QGZ36670.1 SDR_family_NAD(P)-dependent_oxidoreductase BGC0002082.3 NRPS:Type I+PKS 25.0 96.7 79.0 2.76e-15
AJQ95706.1 polyketide_synthase_modules-related_protein BGC0001644.4 PKS 25.0 95.5 77.0 1.53e-14
KIA75596.1 polyketide_synthase BGC0002209.2 PKS 23.0 96.4 76.0 4.34e-14
WP_002283498.1 beta-ketoacyl_synthase_N-terminal-like_domain-containing_protein BGC0002058.3 PKS+NRPS:Type I 26.0 56.8 75.0 4.63e-14
QCY50742.1 PKs_and_AMP-binding_domain-containing_protein BGC0002287.2 NRPS:Type I 26.0 56.8 75.0 4.63e-14
QIE07363.1 polyketide_synthase_NecD BGC0002050.3 NRPS:Type I+PKS:Trans-AT type I 23.0 92.9 75.0 6.9e-14
ABA02240.1 polyketide_synthase BGC0000098.3 PKS 29.0 54.2 75.0 7.72e-14
CAL69893.1 RhiE_protein BGC0001112.5 NRPS:Type I+PKS:Trans-AT type I 26.0 56.8 69.0 7.3e-12