LOCUS       NZ_LIWC01000006        22035 bp    DNA     linear   CON 28-MAR-2024
DEFINITION  Amycolatopsis sp. CB00013 scaffold6, whole genome shotgun sequence.
ACCESSION   NZ_LIWC01000006
VERSION     NZ_LIWC01000006.1
KEYWORDS    WGS; RefSeq.
SOURCE      Amycolatopsis sp. CB00013
  ORGANISM  Amycolatopsis sp. CB00013
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 692634)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 692634)
  AUTHORS   Yan,X., Ge,H., Hindra,F., Yang,D., Huang,T., Crnovcic,I. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-AUG-2015) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2014
            Assembly Method                   :: CLC Genomics Workbench v. 7.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905755.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:05:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,488
            CDSs (total)                      :: 8,430
            Genes (coding)                    :: 8,383
            CDSs (with protein)               :: 8,383
            Genes (RNA)                       :: 58
            rRNAs                             :: 1, 3, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (5S, 23S)
            partial rRNAs                     :: 3 (16S)
            tRNAs                             :: 50
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 47
            CDSs (without protein)            :: 47
            Pseudo Genes (ambiguous residues) :: 0 of 47
            Pseudo Genes (frameshifted)       :: 17 of 47
            Pseudo Genes (incomplete)         :: 38 of 47
            Pseudo Genes (internal stop)      :: 1 of 47
            Pseudo Genes (multiple problems)  :: 9 of 47
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:01:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 519722
            Orig. end                         :: 541757
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LIWC01000006.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22035
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="2"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22035
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22035
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12035](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12035
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     misc_feature    complement(399..413)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
     gene            complement(559..2613)
                     /locus_tag="AMK34_RS36045"
                     /old_locus_tag="AMK34_35710"
     CDS             complement(559..2613)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150523.1"
                     /locus_tag="AMK34_RS36045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_35710"
                     /product="hydantoinase/oxoprolinase family protein"
                     /protein_id="WP_073848324.1"
                     /transl_table=11
                     /translation="MTGLRVGVDIGGTFTDLCVLDETGVVAVGKVLTTHDEPARAVEEG
                     LKRTLADAGLAARDVEQFVHGTTLVTNALIERKGARTALLATAGFRDVLEMRREHRYEL
                     YDLLIELPAPLVPRHLRFDVPERILADGTVHTGLDEEYVARLGRELDARGIDAVAICFL
                     HAFTNPAHERRAAEVLKEVAPRLRVALSSEVVPEIREFERASTTVANVYVQDLTERYLR
                     DLERRLHEAGVRPSPHIMLSNGGIATVDTAARYPIRILESGPAGGALAASAIGAAAGVE
                     DLLAFDMGGTTAKLCMISGGAPLVTHEFEVDRKYRLLPGSGLPVKVPVTDMIEIGVGGG
                     SIARIDALGLLTVGPDSAGSEPGPVCYARGGTEPTVTDADLVLGYLDPGYFLGGGMTLD
                     AEGAREAIRSKIAEPLGVSVEEAAWGIHTSVNEDMANAARVHAVERGKDPAKLPMFTFG
                     GAGPVHGVGVARALGAPEVVAPPAAGVLSAAGFLTAPLAFDFVRSARSAVLDLSWEQVD
                     ALFAEMEAEGAELLEKSGVDSVTHRRIAEMRYSGQGYEVRVPVEQGNWPESLIGAFTET
                     YRTLYRRTGPDVAIEVLNWRVVSSGPAPEVTLKLAGAEVEGDARKGSRPAYFPAEGGFV
                     DSAVFDRYRLKPGDRVDGPAIVEERESTVVVPPGARCVVGEDASLAVTV"
     gene            complement(2610..4241)
                     /locus_tag="AMK34_RS36050"
                     /old_locus_tag="AMK34_35715"
     CDS             complement(2610..4241)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336977.1"
                     /locus_tag="AMK34_RS36050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_35715"
                     /product="thiamine pyrophosphate-binding protein"
                     /protein_id="WP_073848325.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 8.2e-57, bitscore:
                     186.9, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.7e-28, bitscore:
                     93.6, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAPTGAQHFVDALTALGTEVVFGLPGVHNLPLWEALADTDIRLV
                     GVRHEQTAGYAADGYARATGKLGVALVTTGPGAANTLAAVGEAMASAAPVLIIATDIPS
                     TLRRPGVVRGVLHETSDQQAMFAPVTKAGFTVTSADQVAATLHRAARLALQPQSGPVYL
                     GIPTDFLSERTPARRPPRSHARPSEIPDLSEAEALLAAADRPLIWAGGGALRAEAGEAI
                     GKLAERLAAPVLTTFGARGLLSVDHPCLAPNPVHAPEVGALWDEADVVLAIGTDFDGLM
                     TQNWLMPQPKKLIAINVDPDDAAKNYQPDITLVGDARVLVEALKVEERSGIAALVGRLA
                     KVSARVRQRIKEEEPQAADLLSTLDEVLPADAVVVADMCVAGYWIGGFHRVRAPRKLAY
                     PMGWGTLGYGFPAALGAAAAGGGRAICVTGDGGFLFGCGDLHTLAQEQLPVTTIVVDDG
                     GYGMLRYDQDRAGLPRRGVDWDSPDFVGLARSFGVHADRVSGFGRAFRRLLGEFVESDE
                     PNVLVVRARMAPPLNTSPRWYRKESP"
     misc_feature    complement(4143..4145)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(4293..4916)
                     /locus_tag="AMK34_RS36055"
                     /old_locus_tag="AMK34_35720"
     CDS             complement(4293..4916)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033792.1"
                     /locus_tag="AMK34_RS36055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_35720"
                     /product="pyridoxamine 5'-phosphate oxidase family protein"
                     /protein_id="WP_073848326.1"
                     /transl_table=11
                     /translation="MSEFVEVTTEAELREILPPPLERTANKARPKLHEMDRQWLAESPF
                     VLIATSAADGTCDVSPKGDPAGFTLVLDDTRIAIPERPGNRRADGFHNVLSNPHVGLIY
                     LIPGRGDTLRINGRARLVREAPFFDDMIVKGSRPKLALVVDIDEIFHHCQKAFMRSKLW
                     SPESWTPDAMPSRAAIAKTFERPEESMADLEAYYDPAAYSAGLY"
     gene            complement(4909..6066)
                     /locus_tag="AMK34_RS36060"
                     /old_locus_tag="AMK34_35725"
     CDS             complement(4909..6066)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150529.1"
                     /locus_tag="AMK34_RS36060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_35725"
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_073848327.1"
                     /sec_met_domain="DAO (E-value: 5e-69, bitscore: 228.9,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MESLPERTDVVVIGGGIIGVACAYRLAAAGVSVLLLERHTLGAGS
                     TAKAAGGIRSSFTTRVNIEIGLRGLAEYASFAETYGTEIDFRRDGYLYLVTDPADLPEF
                     ERCAELQNSYGVRSRLVEPAEARRFSPLIDTEGVVAALWSPDDAKATPDSAVQGYARAA
                     RGHGAVLRTGVEVVGIDRDGDEITGVRTSAGFVRTDAVVCAAGAWSGRIGELAGVDLPV
                     RPYRRQVVFTGPVADLPGRVPLTIEMPSAFYFHREGPGLAMSFCDGDGDPGFDTRYQPG
                     EWLPKLAEIAARRVPAVLGAGIRGGWAGLYEVTPDRNQIVGESVHLSRFFYATGFSGHG
                     FQMGPAVGELVRDLYLGRVPAIDITGLDVRRFAGDRAVTREHNIV"
     gene            complement(6050..7063)
                     /locus_tag="AMK34_RS36065"
                     /old_locus_tag="AMK34_35730"
     CDS             complement(6050..7063)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GST_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033794.1"
                     /locus_tag="AMK34_RS36065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_35730"
                     /product="glutathione S-transferase C-terminal
                     domain-containing protein"
                     /protein_id="WP_073848328.1"
                     /sec_met_domain="GST_C (E-value: 1.1e-08, bitscore: 30.6,
                     seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIPTDPQTGEFRRSANHFDARVTADGRDGWPVEAGRYRLVVSRA
                     CPWASRGLVVRRLLGLESALSVAVADPIQDDKSWRFTLDPGDRDPVLGIKYLAEAYHAA
                     DPHYMGGISVPAIVDIPSKRLVSNDYPQITLDLSTEWTSLHRPGAPDLYPERLRGEIDD
                     VNAGVYADVNAAVYQAGFATKQAAYEDAYTRLFTMLDVLSERLEKQRYLVGDTITEADI
                     RLFTTLVRFDAVYHGHFKCNRSKLAELPVLWAYARDLFQTPGFGDTVDFDHIKRHYYAV
                     HEQVNPTRIVPLGPDLSGWTTPHHREQLGGRPFGDGTPPGPPPEDERIGDTDGVTA"
     gene            7160..8536
                     /locus_tag="AMK34_RS36070"
                     /old_locus_tag="AMK34_35735"
     CDS             7160..8536
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008374 - O-acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336981.1"
                     /locus_tag="AMK34_RS36070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_35735"
                     /product="wax ester/triacylglycerol synthase family
                     O-acyltransferase"
                     /protein_id="WP_038508792.1"
                     /transl_table=11
                     /translation="MPFMPVTDSMFLLVETREHPMHVGGLQLFKKPEGAGPDYLRDIRK
                     SMLESDNMRSVFRRRPARPVNTAGHLAWSTDTELELDYHFRHSALPQPGRVRELLELTG
                     RWHSTLLDRHRPLWEIHLVEGLQDGRFAIYSKIHHALMDGVSALRHLQGTLSDDPADLD
                     CPPPWGRRAKPDGGRNGKASPSMLSTFGKTVNQLAGIAPAAMKVAREAFQEHTLTLPAQ
                     APKTMLNVPIGGARRFAAQSWSLDRVRKVATAAGVSRNDVVLAMCSGALRDYLIEQNAL
                     PDAPLTAMVPVSLRRKDSGDAAGNNIGALLCNLATHLTDPAARLATINASMRNGKKLFS
                     ELTPLQTLLLSGINVAQLGVSPIPGFVNNTKPPFNLVISNVPGPRKQMYWNGASLDGIY
                     PASVLLDGQALNITLTSNGDNLDFGVTGCRRSVPHLQRILTHLDTALAELEHAVSLPRV
                     "
     gene            complement(8588..9574)
                     /locus_tag="AMK34_RS36075"
                     /old_locus_tag="AMK34_35740"
     CDS             complement(8588..9574)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631253.1"
                     /locus_tag="AMK34_RS36075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_35740"
                     /product="PQQ-dependent sugar dehydrogenase"
                     /protein_id="WP_073848329.1"
                     /transl_table=11
                     /translation="MSLRRTLAATFAAATAVSIAAVPATAAEAPSVQAIRQLASGLNQA
                     WSIDFLPDGTGLFTQKDAKTISKIDKAGKVTTVQTIPGVSVTAEAGLLGIAVSPKYATD
                     ETVFIYYTTSSDNRIAKLKLGQPPTPIVTGIPRGSQYHHGGRIRFGPDGYLYAGTGDGQ
                     NGANAQNKNSLGGKVLRVTTDGAAAPGNPFNSRVYSYGHRNVQGLTWANGQLYISDIGA
                     NKLDELNKIEPGKNYGWPTCEGPCNTAGMTNPVKSWPTSSATPSGLAAYKGSLYMASLK
                     GGTYKLDLNGNGGKLWTNLGRTRDATAGPDGQLYTITPGGLYVSDGS"
     misc_feature    complement(9566..9568)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    9738..9751
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.78"
                     /tool="antismash"
     gene            9829..9924
                     /gene="pqqA"
                     /locus_tag="AMK34_RS36080"
                     /old_locus_tag="AMK34_35745"
     CDS             9829..9924
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033797.1"
                     /locus_tag="AMK34_RS36080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_35745"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_007033797.1"
                     /transl_table=11
                     /translation="MIETIEVWTTPDFVEYETPMEVTAYAARMED"
     gene            10001..10690
                     /gene="pqqC"
                     /locus_tag="AMK34_RS36085"
                     /old_locus_tag="AMK34_35750"
     CDS             10001..10690
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336983.1"
                     /locus_tag="AMK34_RS36085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_35750"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_038508790.1"
                     /sec_met_domain="TIGR02111 (E-value: 7.9e-86, bitscore:
                     282.6, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVMSSSEFIAALRGLSHRYWGTHPFHVRMHEGDLSEYELKIWAA
                     NRWYYQCVLPQKDAAIISNCPLPEIRREWLDRIVYHDGARAGDGGIERWLRLCTAVGLD
                     REEVLDQRHVAPGVRFAVDAYVTFARTKPWLEAVASGLTEMFAGHLMQRRVADMLANYS
                     WIAPEDLAYFTNRIDKVSGEGKGTLDIVVRHAVTREQQEKAIAALSFKTDVLWSMLDAI
                     ERAAAKE"
     gene            10693..10965
                     /gene="pqqD"
                     /locus_tag="AMK34_RS36090"
                     /old_locus_tag="AMK34_35755"
     CDS             10693..10965
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336984.1"
                     /locus_tag="AMK34_RS36090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_35755"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_073848330.1"
                     /sec_met_domain="PqqD_RRE (E-value: 1.2e-23, bitscore:
                     78.1, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 3.3e-10, bitscore: 35.5,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTLERGSVPRLRRGVRLSYDQTRETHVLLFPEGVLVPNATAAAV
                     LSLCDGVEDVAGIASALSKRYAGVREEEILDVLSRLGDRRIVEWT"
     aSDomain        10696..10956
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_AMK34_RS36090_PqqD_RRE.1"
                     /evalue="4.90E-25"
                     /identifier="RREFam006.1"
                     /label="AMK34_RS36090"
                     /locus_tag="AMK34_RS36090"
                     /protein_end="88"
                     /protein_start="1"
                     /score="78.1"
                     /tool="antismash"
                     /translation="TTLERGSVPRLRRGVRLSYDQTRETHVLLFPEGVLVPNATAAAVL
                     SLCDGVEDVAGIASALSKRYAGVREEEILDVLSRLGDRRIVE"
     gene            10956..12035
                     /gene="pqqE"
                     /locus_tag="AMK34_RS36095"
                     /old_locus_tag="AMK34_35760"
     CDS             10956..12035
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150538.1"
                     /locus_tag="AMK34_RS36095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_35760"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_198941818.1"
                     /sec_met_domain="PF04055 (E-value: 1.1e-23, bitscore: 79.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1e-06, bitscore: 24.4,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 8.2e-10, bitscore: 34.4,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.9e-11, bitscore:
                     39.6, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLNTAAPLGMLAELTHRCPLHCPYCSNPVELIARDGELSTEEWL
                     SVLSQARELGVLQVHMSGGEPLARPDLPILVEHATKLGCYVNLVTSGLGLTESRLDDLV
                     ERGIAHIQLSVQGATADRADRLAGARAHDRKLVAAELIKKAGLPLSVNVVLHRQNHDQL
                     AGIIDLAEEMGADRLELANTQYYGWALRNRDALMPTRRQLDEAEPIVRAATERLRGRME
                     IIYVVADYYEQYPKPCMYGWGARQLTVAPDGNVLPCPASTAIETLEFDNVRDKPLAWIW
                     YESASFNAYRGEDWMPDTCGTCDRRAIDFGGCRCQAFQLTGDAAATDPVCSRSPHRGVV
                     DLILSTQAKTDELVMRAPR"
     gene            12032..12895
                     /gene="pqqB"
                     /locus_tag="AMK34_RS36100"
                     /old_locus_tag="AMK34_35765"
     CDS             12032..12895
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631257.1"
                     /locus_tag="AMK34_RS36100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_35765"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_073848331.1"
                     /transl_table=11
                     /translation="MRVILLGTAAGGGFPQWNCACALCVSDAPPRTQDCVAVSADGEGW
                     YLLNVSPDIRAQILATPPLRAGPGPREIPLRGVLLTDAELDHSLGLLLLREAGGLPVWA
                     PDAVLGALSEQFPARSIIDGYGGWQWLPSSDVSIDGLRVSMLPVSDKRPKYARSSTEDG
                     PWVVAYRIEDVQTGGVFVYAPCLKSWPDGFDDFTRDAGLVLLDGTFYAPDEMSGATAAE
                     VGDGAQLAMGHLPITCSLAKLRPGPRWAYTHLNNTNPVIDPASPEHAAVLAGGASLPLD
                     GTDFKL"
     gene            complement(12892..13866)
                     /locus_tag="AMK34_RS36105"
                     /old_locus_tag="AMK34_35770"
     CDS             complement(12892..13866)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009082804.1"
                     /locus_tag="AMK34_RS36105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_35770"
                     /product="aldo/keto reductase"
                     /protein_id="WP_073848332.1"
                     /transl_table=11
                     /translation="MRTTTLGRSGLEVSRIAFGTWQLGGDWGSFDEDTAIAAIHHAREL
                     GVNLFDTAQAYGFGKSEAMLGKALREELKRDRDNLVIATKGGIKPRSERPRDSRREWLT
                     QGIEDSLRFLDVDHIDLYQIHWPDSDAPAEETAGILQEFVDAGKIRHVGVSNYDAAGLA
                     AFDKTRPVETLQPPYHLFRRDIETDPLPYARENDIGVLVYSPLGSGLLTGAFTPETTFE
                     KTDWRSRSSAFTGDTFLRNLAVVDRLKEFAAGKGISVSQLAIAWTLAQPGVHVAIVGAR
                     KAANIEASLAAADIDLSADELAEIDRLTADAVPVSGASPEGVA"
     misc_feature    complement(13927..13940)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.81"
                     /tool="antismash"
     gene            13974..14492
                     /locus_tag="AMK34_RS36110"
                     /old_locus_tag="AMK34_35775"
     CDS             13974..14492
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033803.1"
                     /locus_tag="AMK34_RS36110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_35775"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_073848333.1"
                     /transl_table=11
                     /translation="MSDSPSLDGLRVLAHPVRLRILSLLTGVAMSAAEAARELGETQAN
                     VSYHLRRLHEAGLLDVAEEVRIRGGLAKRYRHDPESGMRFTSKNPDEEQLLIAAMLEEL
                     KRRSEFRLPDERGSISDAEMWVDRETWEKALEHARELSDLLHSAAKPPRTRGTIPVSAT
                     VAMFEMRRP"
     gene            14489..15709
                     /locus_tag="AMK34_RS36115"
                     /old_locus_tag="AMK34_35780"
     CDS             14489..15709
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631260.1"
                     /locus_tag="AMK34_RS36115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_35780"
                     /product="MFS transporter"
                     /protein_id="WP_073848334.1"
                     /transl_table=11
                     /translation="MTSLREPLRQHNFRWLIGGRTFGEFGNAVAPLALAFAVIDLTGSA
                     VDIGIVVGARSVASVVLLLFGGVLADRLPRSVILQGTEVAATLTQAAIAASVLCGFASI
                     PLLVGLSVVNGAVAAISAPASASLTPLTVPATQLAQANALARLLSNSGRIAGAGLGGIL
                     VTAVGPGWALGGNALLFLGSALSYRRIRLDRRERVPGSRPLAELAEGWREFRSRTWVWV
                     VVVQFMVVNAVIAGGIAVLGPVVADSSFGRSGWGFALAAQTIGSLVGGILVARWQPRRA
                     LFVGVAVILFEAPPLILLGQAPLLPLLLAAMFVSGLAIEQFVVAWDVSLQENVPEDKLA
                     RVYSYDMLGSFIALPLGQMAAGPAAQHFGVSTTLLACAALVVAATCLALCSGQVRGLVR
                     KTYAARP"
     gene            complement(15762..17138)
                     /locus_tag="AMK34_RS36120"
                     /old_locus_tag="AMK34_35785"
     CDS             complement(15762..17138)
                     /EC_number="3.5.1.4"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1105: amidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150551.1"
                     /locus_tag="AMK34_RS36120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_35785"
                     /product="amidase"
                     /protein_id="WP_073848335.1"
                     /transl_table=11
                     /translation="MNDTKLTASELVAAYATGELSPVEATQNALRVIEERDGETNAFCL
                     VDADGALEQAKASEVRWRDGNPIGWLDGVPASIKDMFLTQGWPTLRGSRCIDPDQPWDV
                     DSPVTARLRENGLVLLGKTTTPELAWKGVTDNTLTGITRNPVDPSTTAGGSSGGSAAAV
                     AAGMGELSVGTDGGGSIRIPASFCGIVGLKPTHGRIPLFPASPFGPLSHAGPMARSVDD
                     TALLLDVLAMPDYRDPAALAPPVSTYREAVRRDVRGLIAAYSPTLGYVDVDPEVAEIVK
                     SAVQSLGDAGLHIEEADPGFTDPKPAFDILWSTGAAKWLDTFPAGSENKVDPGLRKVWE
                     FGKTFSASDYLGANAERAALGILMGEFHTRYDVLITPTLPIPAFEAGHEVPPGSGLSGW
                     PDWTPFTYPFNMTQQPAISVPAGRTSSGLPVGLQIVGPRHSDDLVLAVAKLLEEVRPWP
                     "
     gene            complement(17147..18136)
                     /locus_tag="AMK34_RS36125"
                     /old_locus_tag="AMK34_35790"
     CDS             complement(17147..18136)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336991.1"
                     /locus_tag="AMK34_RS36125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_35790"
                     /product="D-2-hydroxyacid dehydrogenase"
                     /protein_id="WP_083650099.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 5.8e-52, bitscore:
                     171.0, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIASETPVLAVLCGDTRPPDMRAIEAEAVVRYTDAAGLADALSGA
                     DAFFVYDFLSTAVPGAWHAADRLRWLHIASAGVDPVLFPGLQESDVVLTNSRGVFDGAI
                     AEYVLGVVLAFAKDFARSWDLQRQRQWKHRESERISGRRVLVVGTGPIGRSIARMLRAA
                     GMSVAGVGRRAREGDPDFGDVYASSELSRHLPGADYVVAVAPLTEQTKGMFDAEAFAAM
                     KPGSRFVNVGRGELVVTSDLIGALRDGSLAGAALDVFDTEPLPAESPLWTMENVLISPH
                     MSGDFVGWRNTLVEVFADNFRRWRAGEPLRNVVDKQLGYVPSETLRQG"
     misc_feature    complement(18011..18013)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            18237..18977
                     /locus_tag="AMK34_RS36130"
                     /old_locus_tag="AMK34_35795"
     CDS             18237..18977
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631263.1"
                     /locus_tag="AMK34_RS36130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_35795"
                     /product="maleate isomerase"
                     /protein_id="WP_016336992.1"
                     /transl_table=11
                     /translation="MDFDLLEFEGPLAQRGIGVIAPFDLALERELWRWVPMEVSLHLAR
                     TPYEPVPVSMEMAQLVSDSRHLAAATRDVLHVEPEVVAYLCTSGSFVNGVDYERSLTKA
                     ICDAGATDAVTTSGALAEVLHQLDLHRVSVLTPYDGDLTGKLHDFLAELGVRTVSSDHL
                     GLGGGIWKVSYRTIAERILAADHADAEAIFVSCTNLPTYDLIEPLESALGKPVLTANQL
                     TMWACLRRMNLPIVGPGKWLREVD"
     misc_feature    18249..18251
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            19022..19792
                     /locus_tag="AMK34_RS36135"
                     /old_locus_tag="AMK34_35800"
     CDS             19022..19792
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033808.1"
                     /locus_tag="AMK34_RS36135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_35800"
                     /product="maleate cis-trans isomerase"
                     /protein_id="WP_073848336.1"
                     /transl_table=11
                     /translation="MPITPFAPPEPPSETTTIGFIYPDHAAEDDYPLAEQLLGGDMAGI
                     KLPVEHIYGTDLHAVPELLDLGSESRLADGAALLAKHEPDAVVWACTSGSFVYGWEGAR
                     DQADRLAAVAGVPASSTSFAFVNAAQALGVRRVAVAASYPDDVARLFVEFLGAGGIEVV
                     SMGSADIDTAAEVGGLAPEAVVELAVSRDHPAADALLVPDTAMRTLGEINTLETRLRKP
                     VLTANQVTVWEGLRLTGKAPLVRTLGALFGLRSS"
     gene            19796..20488
                     /locus_tag="AMK34_RS36140"
                     /old_locus_tag="AMK34_35805"
     CDS             19796..20488
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033809.1"
                     /locus_tag="AMK34_RS36140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_35805"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_073848337.1"
                     /transl_table=11
                     /translation="MSLPEIEPVSRESTAGIIARQLRDAIMTGALPPGTQLGETDLASR
                     FQVSRGPLREAMQHLVSEGLLRSERHRGLFVIDLEPGDVYDIYSARSAIERAAMLRALR
                     GDRERVATELEEAVRAMAAAADDDDPTALSWADLRFHEALIAASGSKRLVRMARTLLIE
                     TRMCLTALQGTYQQVKERVTEHTRIIEALRAGDEETALSLLEAHMEDAVQRLAPGTSLR
                     EGEAPAVP"
     gene            complement(20493..20969)
                     /locus_tag="AMK34_RS36145"
                     /old_locus_tag="AMK34_35810"
     CDS             complement(20493..20969)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033810.1"
                     /locus_tag="AMK34_RS36145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_35810"
                     /product="DUF4262 domain-containing protein"
                     /protein_id="WP_038508772.1"
                     /transl_table=11
                     /translation="MCWHCDNPGKTRADYLTEEVRPLIRKYGWMVQTVERGIVQPGFAY
                     TVGLTDAGLPELVVTGLRERRSGQLLNYFAQQVVRSGPPEPGEVLPAEVGWPSLEVVPL
                     SSPSAHLLTAVLLYGENFRALQLVYEDEHGNWPWDREFRGGTGGQPVLGARGRG"
     misc_feature    complement(21104..21115)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.29"
                     /tool="antismash"
     misc_feature    complement(21486..21497)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.32"
                     /tool="antismash"
     misc_feature    complement(21507..21521)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 22.4"
                     /tool="antismash"
     misc_feature    21953..21967
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.7"
                     /tool="antismash"
ORIGIN
        1 tcccggtgac ctgggcgtac agatcgccga tggtctcctc cggggtacgg acgttcgcgc
       61 ggatcagcag ttcgagatcc gcgttgacct cgcccgcgcg gaggaacttc atgatcggca
      121 ggcgcagtcc ctcttcgaag acctcgtgcg cctcggccga gaccagccgt ccgccgatgt
      181 ccggggcgtg gcaacaggaa gcgaaccaag cgaccagcct gccccgcagg aacaccggcg
      241 tcgcgacggt gatgtcgttg atctgcccgg cggtctgcca cggatcgttg gtgagcagga
      301 cgtcgcccgg caccaaggtc tccggcgggt acgcggcgac gaagtggtgc atcccggtcg
      361 ccatcgcgtt gatgtggccg ggggtgccgc cgacggactg gccgatcatc tcgccgcgcg
      421 agtcgaacac cgcacaggcg aggtcgagcg actcccgcac cacggaggag aacgccgtgt
      481 tgacgagcgc gttctgctgt tcggccagga tggagtgcag ccggtttccc agcaatccca
      541 ccagaatcgg gtcgacgctc ataccgtcac cgccagactg gcgtcttcgc cgacgacaca
      601 gcgagccccg ggcggaacga ccacagtgga ctctcgttcc tccacgatgg ccggaccgtc
      661 gacacgatcg cccggcttga gccggtaccg gtcgaacacc gccgagtcga caaatccacc
      721 ttcggcgggg aagtaggccg ggcggctccc cttgcgcgcg tcgccctcga cctcggcgcc
      781 cgcgagtttc agtgtgacct cgggcgccgg cccgctggag acgacccgcc agttgagcac
      841 ctcgatggcg acgtccggcc cggtccgccg gtacaacgtc cgataggtct cggtgaacgc
      901 gccgatgagc gactccggcc agttcccttg ctcgaccggc acgcggacct cgtagccctg
      961 cccggagtac cgcatctcgg cgatccggcg atgcgtcaca ctgtccacac cggacttctc
     1021 cagtagttcc gcaccctcgg cctccatctc ggcgaacaac gcgtcgacct gctcccagga
     1081 gagatcgagc accgccgaac gcgccgaacg gacgaagtcg aacgccagtg gcgcggtgag
     1141 gaatcccgcc gcgctcagca ccccggcggc gggcggcgcg accacctcgg gtgcgccgag
     1201 cgcccgcgcc acgccgacac cgtgcaccgg tccggcgccg ccgaaggtga acatcggcag
     1261 cttcgccgga tccttgccgc gctcgacggc gtggacgcgc gcggcgttgg ccatgtcctc
     1321 gttgacactg gtgtggatgc cccaagcggc ctcctcgacg ctgacgccga gcggttccgc
     1381 gatcttcgag cggatcgcct cgcgtgcgcc ctcggcgtcc agagtcattc cgccaccgag
     1441 gaagtatccc gggtccaggt agccgagcac gaggtcggcg tcggtcacgg tcggctcggt
     1501 gccgcctcgg gcgtagcaga ccgggccggg ctcggaaccc gccgaatccg ggccgacggt
     1561 aagcaggccg agcgcgtcga tacgcgcgat cgagccgccg ccgacgccga tctcgatcat
     1621 gtcggtgacc ggcaccttga ccggcagccc ggatcccggc agcagccggt acttccggtc
     1681 cacttcgaac tcgtgcgtca ccagcggggc gccgccggag atcatgcaca gtttcgccgt
     1741 cgtgccaccc atgtcgaagg ccagcagatc ctcgacaccg gccgcggcgc cgatcgcgga
     1801 cgcggccagc gcgccacccg ccgggccgga ttcgaggatg cggatcggat agcgggcggc
     1861 ggtgtcgacg gtcgcgatcc caccgttgga cagcatgatg tgcggcgacg gccgcacccc
     1921 tgcctcgtgc agacgccgtt ccaggtcgcg cagatagcgc tcggtgaggt cctggacata
     1981 gacgttcgcg accgtggtgg acgcgcgttc gaactcgcgg atctcgggga cgacctcgct
     2041 cgacagagcg acccgcaacc gcggcgccac ctccttgagc acctcggcgg cgcggcgttc
     2101 gtgcgcggga ttcgtgaagg cgtgcaggaa acagatcgcc accgcgtcga tgccacgggc
     2161 gtcgagctct cggccgagcc gtgcgacgta ctcctcatcc agtcctgtgt ggacggttcc
     2221 gtcggcgagg atccgctcgg ggacgtcgaa ccgcagatga cgcgggacca acggggcggg
     2281 gagttcgatg agcaggtcgt acaactcgta gcgatgctcg cggcgcatct ccagcacgtc
     2341 acggaaaccg gcggtcgcga gcaacgcggt gcgcgctccc ttgcgctcga tcagcgcgtt
     2401 cgtgaccagc gtggtgccgt gcacgaactg ctcgacgtcg cgcgcggcca acccggcgtc
     2461 cgcgagtgtc cttttgagac cttcctcgac cgcgcgggcg ggctcgtcgt gggtggtcag
     2521 cactttgccg acggcgacga ccccggtttc gtcgagcacg cagagatcgg tgaacgtacc
     2581 gccgatgtcc acgccgaccc ggagcccggt cacggggatt ccttgcggta ccagcgtggc
     2641 gaggtgttga gcggcggcgc cattctcgcg cggacgacca gcacgttcgg ctcgtcggac
     2701 tcgacgaact cgccgagcag ccgccggaac gcccgcccga accccgagac gcgatccgcg
     2761 tgcacgccga aagaccttgc caggccgacg aaatcggggc tgtcccagtc gacgccgcgc
     2821 cgcggcagcc cggcacgatc ctggtcgtag cggagcatcc cgtacccgcc gtcgtcgacg
     2881 acgatcgtcg tgaccggcaa ctgttcctgc gccagcgtgt ggagatcacc gcagccgaag
     2941 aggaagccgc cgtcaccggt gacacagatc gcgcgtccgc cacccgcggc ggcggcaccg
     3001 agcgccgcgg ggaaaccgta gccgagcgtg ccccagccca tcggatacgc gagcttgcgc
     3061 ggtgcgcgga cccgatggaa cccgccgatc caatacccgg ccacgcacat gtccgcgacc
     3121 acgaccgcgt cggccggcag cacttcgtcc aaagtggaca gaaggtcggc ggcctgcggc
     3181 tcttcttcct tgatccgctg ccggacccgg gcggagacct tggcgagcct gccgacgagc
     3241 gccgcgatcc cggaccgttc ctcgaccttc aacgcctcga cgagcacgcg ggcgtcgccg
     3301 accagcgtga tgtccggctg gtagttcttg gccgcgtcgt cggggtcgac gttgatcgcg
     3361 atgagcttct tcggctgcgg catcagccag ttctgggtca tcagcccgtc gaagtcggtg
     3421 ccgatggcga ggacgacgtc ggcctcgtcc cacagcgcgc cgacctcggg cgcgtgcacc
     3481 gggttcgggg cgagacaagg atgatcgacc gacaggagcc cgcgggcgcc gaacgtggtg
     3541 agcaccggcg cggccagccg ttcggcgagt ttcccgatcg cctcgcccgc ctcggcgcgc
     3601 aacgcaccgc cgcccgccca gatcagcggc cggtcggcgg cggcgagcag ggcttcggcc
     3661 tcgctgagat ccgggatctc cgacggccgg gcgtgcgaac gcggcggacg gcgcgcgggc
     3721 gtccgctcgg acaggaagtc ggtggggatg ccgaggtaga ccggcccgct ctgcggctgg
     3781 agcgcgagcc gggccgcgcg gtggagggtg gcggcgacct ggtcggcgct cgtgacggtg
     3841 aacccggcct tggtgaccgg cgcgaacatc gcctgctgat ccgacgtctc gtgcaggaca
     3901 ccgcggacca cgccgggccg ccgcagcgtg gaggggatgt cggtcgcgat gatcagcacc
     3961 ggcgccgccg acgccatggc ctcaccgacc gcggcgagcg tgttcgccgc gcccggtccg
     4021 gtggtcacca gcgcgacccc gagcttgccc gtggcgcggg cgtacccgtc ggccgcgtac
     4081 ccggccgtct gctcgtgccg gaccccgacg agccggatgt ccgtgtcggc cagcgcctcc
     4141 cataacggca ggttgtgcac cccggggaga ccgaagacga cttcggtccc cagagcggtc
     4201 agcgcgtcga cgaaatgctg ggctccggtg ggtgcaggca ccccgccgat agtgccagat
     4261 cgttcaacga tccagcaacc agccgctgcg cgtcagtaca gaccggccga gtacgcggca
     4321 gggtcgtagt acgcctcgag gtcggccatg ctctcctccg gccgctcgaa ggtcttcgcg
     4381 atcgccgccc gcgacggcat cgcgtcgggc gtccagctct ccggcgacca cagcttcgac
     4441 cgcatgaacg ccttctggca gtggtggaag atctcgtcga tgtcgacgac cagcgcgagc
     4501 ttcggcctgc tgcccttcac gatcatgtcg tcgaagaacg gcgcctcccg cacgagccgc
     4561 gcgcggccgt tgatccgcag cgtgtcacca cggcccggga tgagatagat cagcccgacg
     4621 tgcggattcg acaacacgtt gtggaacccg tcggcgcgcc ggttgcccgg ccgctccggg
     4681 atggcgatcc gcgtgtcgtc cagcaccagc gtgaacccgg ccgggtcgcc cttcggcgaa
     4741 acgtcgcagg tgccgtctgc cgccgaggtc gcgatcagca cgaacggcga ctccgcgagc
     4801 cactgccggt ccatctcgtg cagcttcggg cgcgccttgt tcgcggtccg ctctagcggc
     4861 ggcggcagga tttcgcgcag ctcggcctcg gtggtgactt cgacgaactc agacaatgtt
     4921 gtgctccctc gtcacggccc ggtcgccggc gaaccggcgg acgtcgagcc cggtgatgtc
     4981 gatggccggg acccgcccca ggtagaggtc ccgcaccagc tcccccacgg ccgggcccat
     5041 ctggaacccg tgtcccgaaa accccgtcgc gtagaagaac cgtgacaggt ggacgctttc
     5101 ccccacgatc tggttgcggt cgggggtcac ctcgtacagc ccggcccagc cgccgcggat
     5161 cccggcgccg agcacggcgg gcacccggcg cgcggcgatt tcggcgagtt tcggcagcca
     5221 ctcgcccggc tgatagcggg tgtcgaagcc ggggtcgccg tcaccgtcgc agaaggacat
     5281 cgccaggccg gggccctcgc ggtggaagta gaacgccgag ggcatctcga tggtcagcgg
     5341 cactcgcccg ggcagatccg cgaccgggcc ggtgaacacg acctgccgcc ggtacggccg
     5401 caccgggagg tcgacaccgg ccagctcgcc gatccgtccc gaccacgcgc ccgcggcgca
     5461 gaccaccgcg tccgtccgca cgaaaccggc cgaggtccgg acgccggtga tctcgtcgcc
     5521 gtcgcggtcg atcccgacga cctcgacgcc ggtccgcagc accgcgccgt gcccgcgggc
     5581 cgcccgcgcg tagccctgga ccgcggagtc cggagtcgcc ttggcgtcgt ccggcgacca
     5641 cagcgccgcg accacgcctt cggtgtcgat cagcggggag aaccgccgcg cttcggcggg
     5701 ctcgacgaga cggctgcgga cgccgtagga gttctgcagt tcggcgcagc gctcgaactc
     5761 gggcaggtcg gcggggtcgg tgaccaggta caggtagccg tcgcggcgga agtcgatctc
     5821 ggtcccgtac gtctcggcga aggacgcgta ctcggccagt ccgcgcagcc cgatctcgat
     5881 gttgacccgg gtggtgaacg acgaccggat cccgcccgcc gccttcgccg tcgagcccgc
     5941 accgagggtg tggcgttcga gcagcagcac cgagaccccg gcggcggcga gccggtacgc
     6001 gcaggcgacc ccgatgatgc cgccgccgat cacgacgacg tcggtgcgtt caggcagtga
     6061 ctccatccgt gtccccgatc cgttcgtcct cgggcggcgg tcccggcggc gtgccgtcac
     6121 cgaacgggcg cccgcccagc tgctcccggt gatgcggcgt cgtccagccg gacaggtccg
     6181 gtcccaaggg gacgatccgc gtcgggttca cctgctcgtg caccgcgtag tagtgccgct
     6241 tgatgtggtc gaagtcgacg gtgtcaccga agcccggcgt ttggaagagg tcgcgggcgt
     6301 aggcccacag caccggcagc tcggccagct tgctccggtt gcatttgaag tgcccgtggt
     6361 agacggcgtc gaagcggacg agcgtggtga acaaccggat gtccgcttcg gtgatcgtgt
     6421 caccgacgag gtagcgctgc ttttcgagcc gttcggaaag cacgtccagc atggtgaaga
     6481 ggcgggtgta ggcgtcctcg tacgcggcct gcttggtcgc gaaaccggct tggtacacgg
     6541 ctgcgttgac gtcggcgtag acccccgcgt tgacgtcgtc gatctcgccg cgcagtcgct
     6601 ctgggtagag gtcgggcgcg ccgggccggt ggaggctggt ccattcggtg gacagatcga
     6661 gggtgatctg gggatagtcg ttactcacca gccgtttgct cggaatgtcc acaatggccg
     6721 gaacgctgat cccgcccatg tagtgcggat cggccgcgtg atacgcctcc gcgaggtact
     6781 tgatcccgag taccggatcc cggtcgccgg gatcgagggt gaaccgccag ctcttgtcgt
     6841 cctggatcgg gtcggccacg gccacgctca gcgcggattc gagaccgagc aaccgccgga
     6901 cgaccagccc gcggctcgcc cagggacagg cccggctgac caccagccgg tatctccccg
     6961 cctccaccgg ccagccgtcg cggccgtcgg cggtgacacg cgcgtcgaaa tggttggcgg
     7021 accgacggaa ctcacccgtc tgcggatcgg tcgggatcgt catgtgagcc accctaaagc
     7081 gtgagatggt ggtttcggtg tgcgtagact ctggcacccg gcgtgttcgc acgccgccgc
     7141 gcggaaggtg gtcccgacga tgccgttcat gcccgtgacc gattcgatgt tccttctcgt
     7201 ggagactcgc gaacatccga tgcacgtcgg cggtctgcag ttgttcaaga aacccgaggg
     7261 cgccggtccc gactatcttc gcgacatccg caagagcatg ctcgagtccg acaacatgcg
     7321 ctcggtgttc cggcgccgtc ccgcccggcc ggtcaacacc gccggccacc tcgcctggtc
     7381 gaccgacacc gaactcgaac tcgactacca cttccgccat tccgcgctgc cccagcccgg
     7441 ccgcgtccgc gaactgctgg agctgaccgg acgctggcac agcaccctgc tcgaccggca
     7501 ccgcccgctg tgggagatcc acctggtcga gggtctgcag gacggccggt tcgcgatcta
     7561 cagcaagatc caccacgcgc tgatggacgg tgtctcggcg ctgcggcatc tgcagggcac
     7621 gctgtcggac gacccggccg acctcgactg cccgccgccg tgggggcggc gcgccaaacc
     7681 ggacggcggc cgcaacggca aggcgtcgcc ctcgatgctc agcaccttcg gcaagaccgt
     7741 caaccagctc gccggtatcg cgcccgccgc gatgaaggtg gcacgggaag cgttccagga
     7801 acacacgctc acgctgccgg cgcaggcgcc gaagacgatg ctgaacgtgc cgatcggcgg
     7861 ggcccggcgg ttcgccgcgc agtcgtggtc gctggaccgg gtgcgcaagg tggcgaccgc
     7921 cgccggggtg tcgcgcaacg acgtcgtcct cgcgatgtgc tcgggcgcac tgcgggacta
     7981 cctgatcgaa cagaacgcgc tccccgacgc accgctcacc gcgatggtcc cggtttcctt
     8041 gcggcgcaag gacagtgggg acgcggcggg gaacaacatc ggcgcgctgc tgtgcaacct
     8101 cgccacccat ctgaccgatc cggccgcgcg gctcgcgacg atcaacgcgt ccatgcggaa
     8161 cggcaagaag ctcttctcgg agctgacccc gctgcagacg ctgctgctgt ccgggatcaa
     8221 cgtcgcccag ctcggcgtgt ccccgatccc cggtttcgtg aacaacacga aaccgccgtt
     8281 caacctggtg atctccaacg tgccggggcc gcgcaagcag atgtactgga acggcgcgtc
     8341 gctcgacggc atctatccgg cgtcggtact gctggacggg caggcgctga acatcacgct
     8401 gaccagcaac ggcgacaacc tggacttcgg ggtcaccggc tgccgccgca gcgtgccgca
     8461 tctgcagcgc atcctgaccc atctggacac cgcgctcgcc gaactggaac acgcggtctc
     8521 cctgccccgc gtttagtcct ctggatgcgg tggaccaccg catccagagg actgaacgcg
     8581 ccgggggcta gctgccgtcg gagacgtaca ggccgcccgg ggtgatcgtg tacagctggc
     8641 cgtccgggcc ggcggtcgcg tcacgcgtgc ggccgaggtt ggtccagagc tttccgccgt
     8701 tgccgttcag gtcgagcttg tacgtgccgc ccttgagcga cgccatgtac agcgagccct
     8761 tgtaggccgc gagcccgctc ggcgtcgccg aggacgtcgg ccaggacttg accgggttgg
     8821 tcatccccgc cgtgttgcac gggccttcgc aggtcggcca gccgtagttc ttgcccggct
     8881 cgatcttgtt cagttcgtcg agcttgttcg cgccgatgtc ggagatgtac agctgcccgt
     8941 tcgcccaggt cagcccctgg acgttgcggt ggccgtagga gtagacgcgg ctgttgaacg
     9001 ggttgccggg cgcggcggcg ccgtcggtgg tgacgcgcag gaccttgccg ccgagggagt
     9061 tcttgttctg cgcgttggcg ccgttctggc cgtcgccggt ccccgcgtag aggtagccgt
     9121 ccggcccgaa ccggatccgc ccgccgtgat ggtactgcga accacgcggg atgccggtga
     9181 cgatcggcgt cggcggctgg cccagcttca gcttggcgat gcggttgtcg gaactggtcg
     9241 tgtagtagat gaagaccgtc tcgtcggtgg cgtacttcgg cgagacggcg atgccgagca
     9301 ggcccgcctc cgcggtgacg ctcacgccgg ggatggtctg gaccgtggtg accttgcccg
     9361 ccttgtcgat cttgctgatc gtcttggcgt ccttctgcgt gaaaaggccg gtgccgtcgg
     9421 gcaggaagtc gatcgaccag gcctggttca ggccgctcgc gagctgtctg atcgcctgga
     9481 cggacggcgc ttcggcggcc gtggccggga cggccgcgat cgacacggcc gtcgccgcgg
     9541 cgaacgtggc ggcgagagta cgacgtaagg acatgggacg cctccttcaa ctacccctgg
     9601 agccccgttg agttggatag aaacacacaa cataacgaaa cggacaccac tggacgggct
     9661 atcgggcatg cgggctgtta accgttgtgt gcgccgagcg tgacgaatcg ggcggtgcga
     9721 tccgccatag gtaggaaact ttacaaaata gctccggaaa tcggcggcgc gcttctaggg
     9781 tggcggggct cggcccggtt cgatcccatg tggacgttag gagcggaaat gatcgaaacc
     9841 atcgaggtat ggaccacgcc cgacttcgtc gagtacgaaa cccccatgga ggtcaccgct
     9901 tacgcggccc gcatggagga ctgaatccgc atccggtggt gggggccgtc ccccaccacc
     9961 gcgccgccgt cccgatcagc gagccgttgg aggcagcccg atgtccgtca tgtcgtcgtc
    10021 ggagttcatc gcggctctgc gcgggctttc gcatcgctac tggggaacgc acccgttcca
    10081 cgtgcggatg cacgaaggcg acctgtccga gtacgaactg aagatctggg ccgcgaaccg
    10141 ctggtactac caatgtgtgc tcccgcagaa ggacgcggcc atcatcagca actgcccgct
    10201 gccggagatc cgccgtgaat ggctcgaccg catcgtctac cacgacgggg cgcgggccgg
    10261 ggacggcgga atcgagcgat ggctccgttt gtgcaccgcg gtcgggctcg accgcgaaga
    10321 ggttctcgat cagcggcacg tcgcgcccgg cgtacggttc gccgtcgacg cctacgtgac
    10381 tttcgcccgc acgaaacctt ggctcgaagc ggtcgcttcg gggctgaccg aaatgttcgc
    10441 cggccatctc atgcagcggc gggtcgccga catgctggcg aactattcgt ggatcgcccc
    10501 ggaagacctc gcctacttca ccaatcgcat cgacaaggtc tccggcgagg gcaagggaac
    10561 gctcgacatc gtggtgcggc acgccgtcac ccgtgagcag caggagaagg cgatcgccgc
    10621 gctgtcgttc aagaccgacg tgctgtggtc gatgctcgac gccatcgagc gcgcggcggc
    10681 caaggagtag ccatgaccac actcgaaaga ggctcggtgc cgcggctgcg gcgcggggtc
    10741 cggctgagct acgaccagac cagggaaacg cacgtcctcc tgttccccga aggcgtgctc
    10801 gtcccgaatg ccacggcggc ggccgtactt tccctctgcg acggcgtcga ggacgtcgct
    10861 gggatcgcat cggcattgag caagcgctac gccggtgtcc gcgaggaaga aatcctggac
    10921 gtcctgtccc ggctcggaga tcggcggatc gtcgaatgga cctgaacacc gcggcaccgc
    10981 tgggcatgct ggccgagctg acccatcgct gcccgctgca ttgcccctat tgctcgaatc
    11041 cggtggagct gatcgcccgt gatggcgaac tgtccacaga ggaatggctt tccgtactct
    11101 cgcaggcgcg ggaactcggc gtgctccagg tgcacatgtc cggcggcgag ccgctcgcca
    11161 ggccggatct gcccatcctg gtcgagcacg ccacgaaact gggctgctat gtcaatctgg
    11221 tgacgtccgg gctgggcctg acggagtcca gattggacga tctcgtcgaa cgcggcatcg
    11281 cgcatatcca gctctccgtc cagggcgcga ccgccgaccg tgcggaccgg ctcgccggcg
    11341 ctcgggccca tgaccggaaa ctggtcgccg ccgaactgat caagaaggcc gggctgccgc
    11401 tttcggtcaa cgtcgtgctg caccggcaga accacgacca gctcgccggg atcatcgacc
    11461 tcgccgagga aatgggcgcg gaccggctcg aactggccaa tacgcagtac tacggctggg
    11521 ccctgcgcaa ccgcgacgcc ctgatgccga cccggcggca actcgacgag gccgaaccga
    11581 tcgtgcgcgc ggccaccgaa cggctgcgcg gccggatgga gatcatctac gtcgtcgccg
    11641 actactacga gcagtacccg aagccgtgca tgtacggctg gggtgcgcgg caattgacgg
    11701 tggcgcccga cggcaacgtg ctgccgtgtc ccgcgtcgac ggcgatcgag accctggaat
    11761 tcgacaacgt gcgggacaag ccgctggcct ggatctggta cgaatccgct tccttcaacg
    11821 cttatcgcgg cgaggactgg atgccggaca cctgcggcac ctgcgatcgg cgcgcgatcg
    11881 acttcggcgg ctgccggtgc caggcgttcc agctcaccgg tgacgccgcc gcgaccgacc
    11941 cggtgtgctc gcgttcaccg catcgcggcg tcgtcgacct cattctgtcc acacaagcga
    12001 aaacggacga actcgtgatg cgggcgccgc gatgagggtg atcctgctcg gtaccgctgc
    12061 gggcggcggt ttcccgcaat ggaactgcgc ctgcgcgctg tgcgtctcgg acgcgccgcc
    12121 gcggacccag gactgtgtcg cggtgagcgc ggacggcgag ggctggtacc tgctcaacgt
    12181 gtcaccggac atccgcgcgc agatcctcgc cacgccgccc ttgcgcgccg ggccggggcc
    12241 gcgggaaatc ccgctgcgcg gggtgttgct gaccgacgcc gaactcgacc attccctcgg
    12301 cctgctcctg ttgcgggaag cgggcggcct tcccgtgtgg gcaccggacg ccgttctggg
    12361 tgccttgtcc gaacagtttc ccgcgcgatc gatcatcgac ggttacggtg gctggcagtg
    12421 gctgccgtcg tcggatgtct ccatcgacgg tctccgcgtg agcatgcttc ccgtgagcga
    12481 caagcggccg aagtacgccc gttcgtccac tgaggacgga ccgtgggtgg tggcgtaccg
    12541 gatcgaagat gtccagaccg gcggcgtctt cgtatacgca ccatgcttga agagctggcc
    12601 ggacgggttc gacgacttca cccgcgacgc cggcctggtg ctgctggacg gaaccttcta
    12661 cgcgccggac gagatgtcgg gcgccaccgc ggccgaggtc ggcgacggcg cccagctggc
    12721 gatggggcat ctgccgatca cctgcagtct cgcgaagctg cggcccggcc cgcggtgggc
    12781 gtacacgcat ctgaacaaca cgaacccggt gatcgacccg gcctcgccgg agcacgccgc
    12841 cgtactggcc ggcggcgcct cccttccgtt ggacggtacg gatttcaagc tctaggcgac
    12901 gccttcgggg ctagcgcccg aaacgggaac ggcgtcggct gtgagacgat cgatctccgc
    12961 gagctcgtcc gcggacaggt cgatgtcggc ggcggcgagg ctggcctcga tgttggccgc
    13021 cttgcgcgcg cccacgatcg cgacgtgcac gcccggctgg gcgagcgtcc acgcgatcgc
    13081 gagctggctg accgagatcc ccttgcccgc ggcgaattcc ttgagcctgt cgaccacggc
    13141 gaggttgcgc aggaaggtgt ctccggtgaa cgccgacgac cgggaccgcc agtcggtctt
    13201 ctcgaacgtc gtctcgggcg tgaaggctcc ggtcagcagg ccgctgccga gcgggctgta
    13261 cacgaggaca ccgatgtcgt tctcccgcgc gtacggcaga ggatcggtct cgatgtcgcg
    13321 gcggaacagg tgatacggcg gctgcagggt ttccaccgga cgggtcttgt cgaaggcggc
    13381 cagcccggcg gcgtcgtagt tcgagacgcc gacatgccgg atcttcccgg cgtcgacgaa
    13441 ctcctgcagg attcccgccg tctcctcggc cggggcgtcg gagtcgggcc agtggatctg
    13501 gtagaggtcg atgtggtcga cgtcgaggaa gcgaagactg tcctcgatgc cttgcgtcag
    13561 ccactcgcgc cgggagtcgc gtggccgttc ggagcgcggt ttgatgccgc ctttcgtcgc
    13621 gatgacgagg ttgtcgcggt cgcgcttgag ttcctcgcgc agcgccttcc ccagcatggc
    13681 ttcggatttc ccgaaaccgt aggcctgcgc ggtgtcgaag aggttgacgc cgagttcgcg
    13741 ggcgtggtgg atcgcggcga tcgccgtgtc ctcgtcgaac gaaccccagt ccccaccgag
    13801 ctgccaggtg ccgaaggcga tcctcgacac ctcgagaccg ctcctgccca atgtcgtcgt
    13861 acgcatgact ccagcagagc acagacatcg gatcaccgca ccggttctcc cggccaacga
    13921 aacccccaaa taactgtttg acggttgacg tcccggcagt cgatactcgt ggcatgtccg
    13981 actcccccag cctcgatggg cttcgcgtcc tcgcccatcc agtgcggctg cgcattctgt
    14041 cgcttttgac cggtgtcgcg atgagcgcgg ccgaagccgc gcgcgaactc ggtgagacac
    14101 aagcgaatgt cagctatcac ctgcggcggt tgcacgaggc cgggctgctc gacgtcgccg
    14161 aggaggtccg gatccggggc gggctggcga aacgctaccg ccacgatccg gagtccggga
    14221 tgcggttcac ctcgaagaac cccgacgagg aacagctgct catcgcggcg atgctcgaag
    14281 aactcaagcg ccgcagcgag ttccgcctgc cggacgaacg cgggtcgatc agcgacgcgg
    14341 agatgtgggt cgaccgcgag acctgggaga aggcactcga acacgcccgc gaactgagcg
    14401 atctgttgca ctcggccgcg aaaccacccc gcacccgggg cacgatcccg gtcagcgcga
    14461 cggtcgcgat gttcgagatg aggcgaccgt gacgtccctg cgcgaaccgc tgcgccagca
    14521 caacttccgc tggctgatcg gtggccgcac gttcggggag ttcggcaacg ccgtcgcccc
    14581 gctcgcgctc gcgttcgccg tgatcgacct gaccggttcc gccgtcgaca tcggcatcgt
    14641 cgtcggcgcc cgctcggtgg cgagcgtggt cctgctcctg ttcggcggcg tgctcgcgga
    14701 ccggctgccg cgctcggtga tcctgcaagg taccgaggtc gccgccaccc tgacccaggc
    14761 cgccatcgcc gcgagtgtcc tatgtggatt cgcgtcgatc ccgctcttgg tcggcctgag
    14821 cgtggtcaac ggcgcggtcg ccgcgatctc ggcacccgcg tcggcgtcgc tcaccccgct
    14881 gacggtgccc gccacgcagc tcgcgcaggc gaacgcgctg gccaggctgc tgtcgaactc
    14941 cggccggatc gccggtgccg gactcggcgg catcctggtc accgcggtcg gccccggctg
    15001 ggcgctcggc ggcaacgcgc tcctgttcct gggctccgcc ctgtcctacc ggcgcatccg
    15061 cctcgaccgc cgggaacggg tccccggcag ccgcccgctg gcggaactcg ccgaaggctg
    15121 gcgcgaattc cggtcacgga cgtgggtgtg ggtcgtggtc gtgcagttca tggtggtgaa
    15181 cgccgtcatc gccggcggga tcgcggtgct cggtcccgtc gtcgccgaca gcagcttcgg
    15241 acgctccggc tggggtttcg ccctcgccgc gcagacgatc ggctcgctcg tcggcgggat
    15301 cctcgtggcc cgatggcagc cgcggcgcgc gctgttcgtc ggggtcgcgg tgatcctctt
    15361 cgaagcgccg ccgctgatcc tcctcggcca ggcgcccttg ctcccgttgc tgctcgcggc
    15421 catgttcgtc tccggactgg cgatcgagca gttcgtggtc gcgtgggacg tctcgctgca
    15481 ggagaacgtg cccgaggaca aactcgcgcg cgtctactcc tacgacatgc tcggttcctt
    15541 catcgccctg ccgcttggcc agatggcggc cggaccggcc gcacagcact tcggggtcag
    15601 cacgaccctg ctcgcgtgcg ccgccctggt cgtggccgcc acctgtctcg ccctgtgcag
    15661 cggccaggtg cgcggactgg tccggaagac ctacgccgcc cggccctgac cgcccgcccc
    15721 gcgaaagtgg tagcaaaggt cccttgctcc ctttccgcag gtcacggcca ggggcggacc
    15781 tcctcgagga gcttcgcgac cgcgagcacc aggtcgtcgg agtgccgcgg gccgacgatc
    15841 tgcagaccga ccggaaggcc gctggaggtg cggccggccg gaacgctgat ggcgggctgc
    15901 tgggtcatgt tgaacgggta ggtgaacggc gtccagtccg gccagccgct cagcccgctt
    15961 cccggcggca cctcgtgtcc ggcttcgaag gcggggatcg gcagcgtcgg cgtgatcagc
    16021 acgtcgtagc gcgtgtggaa ctcgcccatc aggatgccca gcgcggcccg ctcggcgttg
    16081 gcgccgaggt agtcgctcgc cgagaaggtc ttgccgaatt cccagacctt ccgcagcccg
    16141 ggatcgacct tgttctccga accggcgggg aaggtgtcca gccacttggc cgcccccgtc
    16201 gaccacagga tgtcgaaggc gggcttggga tccgtgaaac cgggatcggc ctcttcgatg
    16261 tgcaggcccg cgtcaccgag cgactggacc gccgatttga cgatctccgc gacctccgga
    16321 tcgacatcga cgtagccgag cgtcggcgag tacgcggcga tcagccctcg cacgtcccgg
    16381 cggacggcct cgcggtaggt cgagacgggc ggggcgagcg cggccgggtc gcggtaatcg
    16441 ggcatcgcga gaacgtcgag gagcagcgcc gtgtcgtcca ccgaccgcgc catcgggccg
    16501 gcgtgcgaga gcggcccgaa cgggctcgcc gggaacagcg ggatccggcc gtgtgtcggt
    16561 ttgagaccga cgattccgca gaacgaagcc ggaatccgga tcgagccgcc accgtcggtg
    16621 ccgacggaaa gctcgcccat ccccgccgcg acggccgcgg cactgccccc gctggagccg
    16681 cccgccgtcg tcgacgggtc gaccgggttg cgggtgatcc cggtcagcgt gttgtcggtg
    16741 acgcccttcc acgccagttc cggcgtcgtg gtctttccca gcagtaccaa gccgttctcg
    16801 cgcagtcgcg cggtgaccgg gctgtcgacg tcccacggct ggtctgggtc gatgcaccgc
    16861 gaaccgcgca gcgtcggcca gccctgcgtc aggaacatgt ccttgatcga cgccgggaca
    16921 ccgtcgagcc agccgatcgg attaccgtcc cgccaccgaa cctcggacgc tttcgcctgt
    16981 tcgagcgcgc cgtcggcgtc gaccaggcag aaggcgttgg tctcaccgtc gcgttcctcg
    17041 atgacacgca acgcgttctg ggtggcctcg accggcgaca gctctccggt ggcatacgcg
    17101 gcgacgagct cgctcgcggt caacttggtg tcgttcaatc cggcccctaa ccttggcgaa
    17161 gcgtctccga cggcacgtat ccgagctgct tgtccacgac gttgcgcagc ggctcccccg
    17221 cgcgccagcg acggaagttg tccgcgaaca cctctaccag agtattacgc cagccgacga
    17281 agtcgcccga catatgcggc gagatcagca cgttctccat agtccacaaa ggactttcgg
    17341 caggcagtgg ctcggtgtcg aagacgtcga gcgccgcacc ggcgagcgag ccgtcccgca
    17401 gcgcgccgat cagatccgag gtgacgacca gttcaccgcg gccgacgttg acgaaccggg
    17461 agccgggttt catcgcggcg aaggcctccg cgtcgaacat gcccttggtc tgctcggtca
    17521 acggcgcgac cgcgacgacg tagtccgctc cgggaagatg acgagacagc tccgaagacg
    17581 cgtacacgtc gccgaagtcg ggatcgccct cacgagcacg gcgtccgaca cccgccaccg
    17641 acatcccggc cgcccgcagc atccgagcga tcgaccggcc gatcggtccg gtgccgacca
    17701 ccagtacccg gcggccggag atccgttcac tctcccggtg cttccactgc cgctgcctct
    17761 gcaggtccca cgaccgggcg aaatccttgg cgaacgcgag gacgaccccg agcacgtact
    17821 cggctatcgc cccgtcgaac accccccgcg aattggtgag tacgacgtcg ctctcctgca
    17881 gccccgggaa gagcaccggg tcgacgcccg cgctggcgat gtgcagccag cgcagccgat
    17941 cggccgcgtg ccaggcgccc gggacggcgg tggacaggaa gtcgtagacg aagaacgcgt
    18001 cggcgccgga taacgcatcg gccaacccgg ccgcgtcggt gtaacgaacc accgcttcgg
    18061 cttcgatagc gcgcatgtcc ggtgggcgcg tgtctccgca gagcaccgcc agcacagggg
    18121 tctccgaggc gatcacgttg acaccgtaaa agtggctcgt atgattgtca acaatccgag
    18181 gaacgacccc cggagcaccg gacctgtgac agcagaagct ttccggaggc tgagacttgg
    18241 atttcgactt actggagttc gaaggcccgt tggcgcagcg cggtatcggc gtgatcgccc
    18301 ccttcgacct cgccctggaa cgcgagctgt ggcgctgggt tcccatggag gtctccctcc
    18361 atctggcgcg cacaccgtac gagccggtgc ccgtcagcat ggagatggcc cagctcgtca
    18421 gcgacagcag gcatctcgcc gccgccacga gggacgtgct ccacgtggag cccgaagtcg
    18481 tcgcctatct gtgcacctcc ggcagtttcg tcaacggtgt ggactacgaa cgttctctga
    18541 ccaaggcgat ctgcgacgcg ggcgcgacgg acgccgtcac cacgtccgga gcgctggcgg
    18601 aggtcctgca tcaactcgac ctccaccggg tctcggtgct gacgccctac gacggcgacc
    18661 tgaccgggaa gctgcacgac ttcctggccg aactcggcgt ccgcaccgtt tcgagcgacc
    18721 atctcggcct gggcggcggc atctggaagg tcagctaccg gaccatcgcc gaacgcatcc
    18781 tcgccgccga ccacgccgac gccgaagcca ttttcgtcag ttgcaccaac ctccccacct
    18841 acgatctgat cgagccactc gaaagcgcgc tcggcaaacc cgtcctcacc gcgaatcagc
    18901 tcacgatgtg ggcctgcctc cggcggatga acctgccgat cgtcgggccc ggcaagtggc
    18961 tccgggaggt cgactgacct cttcccttac gattgtcgac aatctgccct ccggaggttc
    19021 cgtgcccatc acgccgttcg ccccacccga gccgccgtcc gagacgacca ccatcgggtt
    19081 catctatccc gatcacgcgg ccgaagacga ctacccgctc gcggaacagc tcctcggcgg
    19141 ggacatggcc gggatcaaac tgccggtcga gcacatctac gggaccgacc tgcacgccgt
    19201 gcccgagctc cttgacctcg gcagcgaaag ccggctcgcc gacggcgccg cactgctggc
    19261 caaacacgaa ccggacgcgg tggtctgggc gtgcaccagc ggcagtttcg tctacggctg
    19321 ggaaggcgcc cgcgatcagg ccgaccggct ggccgccgtc gccggcgtcc cggcgtcgag
    19381 cacctccttc gccttcgtca acgccgcaca ggccctcggc gtccggcggg tcgcggtcgc
    19441 cgccagctac cccgacgacg tcgcccgcct gttcgtcgaa ttcctcggcg cgggcgggat
    19501 cgaagtggtc tcgatgggca gcgcggacat cgacaccgcc gccgaggtcg gcggactcgc
    19561 cccggaagcc gtcgtcgaac tcgcggtgag ccgcgaccac ccggccgccg acgccctgct
    19621 cgtccccgac accgccatgc ggacgctcgg cgagatcaac acgctcgaaa ccaggctccg
    19681 caagccagtg ctgaccgcca accaggtcac cgtctgggag ggcctgcggc tcaccggcaa
    19741 ggccccgctc gtccgcacct tgggcgccct gttcggactg aggagcagct gaaccatgtc
    19801 cttgccggaa atcgagccgg tcagccggga gtccaccgcc gggatcatcg cgcgccagct
    19861 gcgggacgcg atcatgaccg gcgccctccc tcccggcacc cagctcggtg aaacggacct
    19921 ggcctcccgg ttccaggttt cgcggggacc gctgcgcgag gcgatgcagc acctcgtctc
    19981 cgaagggctc ctgcgcagtg agcgccaccg cggtctgttc gtgatcgacc tcgaacccgg
    20041 cgacgtctac gacatctact cggcgcgctc ggccatcgaa cgcgccgcga tgctgcgcgc
    20101 cttgcgcggg gaccgggaac gggtcgccac cgaactcgaa gaggccgtgc gcgccatggc
    20161 cgccgccgcg gacgacgacg acccgaccgc gctctcctgg gcggatctcc ggttccacga
    20221 ggcgctgatc gccgcctccg gcagcaaacg gctcgtgcgc atggcacgga cgctgctgat
    20281 cgagacccgg atgtgcctca ccgctctgca gggcacctat cagcaggtca aagaacgggt
    20341 caccgagcac accaggatca tcgaggccct gcgggcgggc gacgaagaga ccgcgctttc
    20401 gctgctggaa gcccatatgg aggacgccgt ccagcgactg gcaccgggaa ccagcctgcg
    20461 ggagggcgaa gctcccgcgg tgccctaggg attcagccac ggccccgcgc ccccagcacc
    20521 ggctgcccac cggtcccgcc acggaactcc ctgtcccacg gccaatttcc gtgctcgtcc
    20581 tcgtagacca gttgcagggc gcggaagttc tcgccgtaca gcaggacggc ggtgagcaga
    20641 tgcgccgacg gcgaactgag cgggacgacc tccaatgacg gccatcccac ctccgcgggc
    20701 agcacctcgc ccggctccgg cggccccgac cggaccacct gctgggcgaa atagttcagc
    20761 agctgaccgg atcttcgttc tctcaggccg gtgacgacca gttccggaag cccggcgtcg
    20821 gtgagcccga ccgtgtacgc gaatcctggt tgcacgattc cgcgctcgac cgtctgcacc
    20881 atccagccgt acttccggat cagcgggcgg acctcctcgg tgaggtagtc ggcgcgggtc
    20941 ttcccggggt tgtcgcaatg ccagcacatc ggcactcctc cagtcgtcga atccgatgat
    21001 cgacactgtg caccggggca ccgacaaaaa ctcgcgcccc ggatcggcgc acgtgcgacg
    21061 agcgggcttt catactggac ttcgtgccga gattcccttt cgtggcaacg ttttccgtcg
    21121 tgagaaaatc tgcaggtttg ccgagaggaa cgaactctgc gaagttcaac ggcgggaccg
    21181 gcactatcga gcggtacggc aaggtgacgt gttgcgaaag ccactttcgc aacgctgaag
    21241 gttgggaaag tggctttcgc aaccctcccg cacgaaccgg accgtgaagg cccccttcat
    21301 tgcgcctaac gcagcgaagg gggccttcac gtactacccg aaaccatgaa tggaccattc
    21361 atgacatcca ggacttgaca cgtcaccggg cggatggttc aagatagagc ggcgaccacc
    21421 gcggacccga gttcggcggt ggtggacttc ccgccgaggt cgggtgtctg cacggtcccc
    21481 tcctcgagaa ccttttccac cgcggcgcgt acatcttgtg ccgcaacggt ttccccgaga
    21541 tgttcgagca gcatcgcccc cgccaggatc tgcgccaccg gattcgcgat gccctgtccg
    21601 gcgatgtcgg gagcgctgcc gtgtaccgcc tcgaacatgg aagggagctc accggtcgga
    21661 ttgatattgc ccgaaggcgc cattccgagc ccgcccgtca cggccgccgc caggtcgctc
    21721 aggatgtcgc cgaacagatt ggaagcgacc acgacgtcga gccggtccgg cgcctgcacc
    21781 atccgcgcgg cgagcgcgtc gacatgacat tgttcggcgt gcacgtccgg atactccgaa
    21841 gagatctcgg cgaagatctc gtcccagaac ggcatcgagt gaatgagccc gttggacttg
    21901 gtcgccgagc agacccgacc cgtccgcgtc ttcgccaact cgaaggcgta gcggatgatc
    21961 cgctccaccc ccacccgcgt gaacacggat tcctgtaaga cgaactcgtt gccgagaccg
    22021 cggttgtgcc tgccc
//
