LOCUS       NZ_LIWC01000002        22544 bp    DNA     linear   CON 28-MAR-2024
DEFINITION  Amycolatopsis sp. CB00013 scaffold2, whole genome shotgun sequence.
ACCESSION   NZ_LIWC01000002
VERSION     NZ_LIWC01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Amycolatopsis sp. CB00013
  ORGANISM  Amycolatopsis sp. CB00013
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 1966077)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1966077)
  AUTHORS   Yan,X., Ge,H., Hindra,F., Yang,D., Huang,T., Crnovcic,I. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-AUG-2015) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2014
            Assembly Method                   :: CLC Genomics Workbench v. 7.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905755.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:05:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,488
            CDSs (total)                      :: 8,430
            Genes (coding)                    :: 8,383
            CDSs (with protein)               :: 8,383
            Genes (RNA)                       :: 58
            rRNAs                             :: 1, 3, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (5S, 23S)
            partial rRNAs                     :: 3 (16S)
            tRNAs                             :: 50
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 47
            CDSs (without protein)            :: 47
            Pseudo Genes (ambiguous residues) :: 0 of 47
            Pseudo Genes (frameshifted)       :: 17 of 47
            Pseudo Genes (incomplete)         :: 38 of 47
            Pseudo Genes (internal stop)      :: 1 of 47
            Pseudo Genes (multiple problems)  :: 9 of 47
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:01:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1786978
            Orig. end                         :: 1809522
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LIWC01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22544
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="4"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22544
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22544
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12544](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12544
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     gene            complement(97..816)
                     /locus_tag="AMK34_RS18675"
                     /old_locus_tag="AMK34_18515"
     CDS             complement(97..816)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030752.1"
                     /locus_tag="AMK34_RS18675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_18515"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_038520354.1"
                     /transl_table=11
                     /translation="MLTIGQLAATAGVTVRTVRHYHHIGLLPEPERDASGYRRYTAQAA
                     VDLIRIRTLADAGVPLARVDALLHAEPAEFAAAISDIDAELRRKIDRLAENRLRIAELT
                     GGERLVLPPDVVALLERMRGLGVSEQRVLLERDAWILMRALDPRAVPERVREKNAAFDD
                     PETLRVYLACDQAVGWDPRDPRLDALIDDLDAWAVEHERRGGRPGYGELVVSRVSEASP
                     AWQRVVGELARRRAERG"
     gene            complement(837..1670)
                     /locus_tag="AMK34_RS18680"
                     /old_locus_tag="AMK34_18520"
     CDS             complement(837..1670)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (27-138). E-value:
                     4.8e-14. Score: 44.5. Matches aSDomain:
                     nrpspksdomains_AMK34_RS18680_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030753.1"
                     /locus_tag="AMK34_RS18680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_18520"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_073846123.1"
                     /sec_met_domain="PF00561 (E-value: 1.8e-11, bitscore: 41.0,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.1e-11, bitscore:
                     42.6, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNTPPVGGLQEIDEHRLFVHRSGEGGPAVVFLPGAGAVGLDYFG
                     VQQEVARFTTAVVYDRGGTGHSDALPLPRTAAAVASELRELLVSLDIPAPYVLAAHSLG
                     GLYAHRFAQLYPRDVAGLVFLDALHPDWDDFMPPEASLSAAGRPSPGPDRAALRAMYAE
                     LREDYPEDVREALVDAKVSDEWLRIGAAERTGLVALATELRAGPELPDVPAIALTVVAH
                     PPQEIDEAKLKMDAARVGGFSRGEQRVLNDTLHHRLCFDRPDAVVQAIRDVVDGI"
     aSDomain        complement(1257..1589)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMK34_RS18680_Abhydrolase_1.1"
                     /evalue="4.80E-14"
                     /label="AMK34_RS18680_Abhydrolase_1.1"
                     /locus_tag="AMK34_RS18680"
                     /protein_end="138"
                     /protein_start="27"
                     /score="44.5"
                     /tool="antismash"
                     /translation="PAVVFLPGAGAVGLDYFGVQQEVARFTTAVVYDRGGTGHSDALPL
                     PRTAAAVASELRELLVSLDIPAPYVLAAHSLGGLYAHRFAQLYPRDVAGLVFLDALHPD
                     WDDFMPP"
     CDS_motif       complement(1332..1388)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMK34_RS18680_0001"
                     /evalue="9.30E-04"
                     /label="NRPS-te1"
                     /locus_tag="AMK34_RS18680"
                     /protein_end="113"
                     /protein_start="94"
                     /score="11.8"
                     /tool="antismash"
                     /translation="PYVLAAHSLGGLYAHRFAQ"
     misc_feature    complement(1845..1854)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.1"
                     /tool="antismash"
     gene            1854..2057
                     /locus_tag="AMK34_RS18685"
                     /old_locus_tag="AMK34_18525"
     CDS             1854..2057
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0001072 - transcription antitermination
                     factor activity, RNA binding [Evidence IEA]"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1255: cold-shock
                     DNA-binding domain protein"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005441988.1"
                     /locus_tag="AMK34_RS18685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_18525"
                     /product="cold-shock protein"
                     /protein_id="WP_005149851.1"
                     /transl_table=11
                     /translation="MAQGSVKWFNGEKGFGFIAQDDGGPDVFVHYSEIQGSGFKSLDEG
                     QRVEFEIGQGQKGPQAQRVVAI"
     gene            2160..2804
                     /locus_tag="AMK34_RS18690"
                     /old_locus_tag="AMK34_18530"
     CDS             2160..2804
                     /EC_number="2.3.1.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030754.1"
                     /locus_tag="AMK34_RS18690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_18530"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_073846124.1"
                     /transl_table=11
                     /translation="MRPDAVSRSALEPEQVGRKVRLREVGLRDRRVLMGFDRDMAREAT
                     PLIGGGHRHWASHRSGSAGDDIHFGIETVRGRMLVGSVCTIGADPATGRFGYGIGIAPR
                     HQRCGYATDAITVLLAHMFGQRGFRKCEVSVYGGNLASLSLHGGLGFREEGRLRDTEVV
                     RGEIKYLVRMGITAEEFAARPLDALGDLGRRGQHRRPRRGKHWRAPAAVSG"
     gene            complement(2794..3441)
                     /locus_tag="AMK34_RS18695"
                     /old_locus_tag="AMK34_18535"
     CDS             complement(2794..3441)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005163340.1"
                     /locus_tag="AMK34_RS18695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_18535"
                     /product="response regulator transcription factor"
                     /protein_id="WP_038520348.1"
                     /transl_table=11
                     /translation="MTIRVVIADDQSLVRTGLRMILDNADDIDVVGEAGDGAEAVALVA
                     DLDPDVVLMDIRMPEMDGVEATAAIAAAHRARVLVLTTFDLDEYVYAALQAGASGFLLK
                     DALAPDLLSGVRVVASGEATLAPTVTRRLLDRVVTGLPAAPPDDRLALLTGRENEVLQQ
                     LARGLSNAEIAELLFLSPGTVKTHVGRILTKLGLRDRVQAVVFAYESGLISR"
     gene            complement(3438..4634)
                     /locus_tag="AMK34_RS18700"
                     /old_locus_tag="AMK34_18540"
     CDS             complement(3438..4634)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016330820.1"
                     /locus_tag="AMK34_RS18700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_18540"
                     /product="sensor histidine kinase"
                     /protein_id="WP_073846125.1"
                     /transl_table=11
                     /translation="MLSFLRNHPKAVDIGLTVLIGLSTVVSADDPEGFDWWLTSLVSLA
                     SLLVRHRNPTITFATGATVSLLHLAMGNDLRPVDVVALIGLFSVAAWGSRRLSFALLAA
                     SLLVAGAWAIHAADANTREPAPPPPRIIIIDRLAPPGPEDDQVQDWGGFAGIGLSLAVA
                     WLAGLNTRQRRIRLSVLEQRAADLERERDTQAALAVAAERGRISRELHDVVAHALSVVV
                     LQAQGAQAELERRPERAREALDAIVGTGRTALGEIRRLLGALGQDEPDWEPQPGAERLP
                     RLAADIRSAGTPVEFLVEGEPRPLSSTVDLAAYRIVQEALTNVLKHAGPAASVTIVMRY
                     GPETLEIEVTDDGIATEEPSGAGHGLEGMRERVNVLGGTFDAGPRPERGFVVRATLPS"
     misc_feature    4774..4789
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.05"
                     /tool="antismash"
     gene            4775..5863
                     /locus_tag="AMK34_RS18705"
                     /old_locus_tag="AMK34_18545"
     CDS             4775..5863
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016330821.1"
                     /locus_tag="AMK34_RS18705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_18545"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_073846126.1"
                     /transl_table=11
                     /translation="MRRLLVALVALAGMVSLASPAAAAPRLKLPPPTGSHPVGSSDLHL
                     IDSSRKDPWVPTGPRELMVSMFYPALVPFGAKRPYLTSAEAKAFLTESGLPDVDPGLLS
                     GLRTSARVDAPPLPGRHALVVLSPGFGKPRTTLTGLAEDLASKGFVVALIGHNYESHGT
                     AFPDGHVTECAACGSDSMLLPPIRSADVSFVLDTLTKPSSRWARLIDRTRIGMAGHSIG
                     GYSAPTAMVDDQRIRAGVDMDGRLWSPIPASGIDRPFLLLGRESEYTPAGPDTTWAGSW
                     PNLTGWKRWISVATAGHASFTDVGVLGEQLGLTKPGLLGGERGMQLTRAYVSAFFDANL
                     RGGHQPLLDGPVADNPEIKFWN"
     gene            complement(5860..6816)
                     /locus_tag="AMK34_RS18710"
                     /old_locus_tag="AMK34_18550"
     CDS             complement(5860..6816)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016330822.1"
                     /locus_tag="AMK34_RS18710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_18550"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_073846127.1"
                     /transl_table=11
                     /translation="MTTAQHKIGSGFGPRSTAEEVLNGIDLSGRLALVTGGYSGLGLET
                     TRALANAGAHVVVPARRPADAEAALAGIPGTEVGELDLADLASVESFAGRFLGTGRPID
                     ILIASAGIMAAPERRVGPGWESHFAICHLGHHALVNRLWPALKAGGGARVVTVASSGHH
                     SSPMRWDDVQFERGYDRWLAYGQAKTANVLFAVHLDKLGTEHGIRAFSLHPGAILTPLQ
                     RHLRPEEMVERGWIDEHGNQADPEFKSPEQGAATQVWAATSPRLDGLGGLYCEDCDVAE
                     IAAEEGEWVGVRPYAIDAGEAERLWKFSAGLTGVPLG"
     gene            6873..7265
                     /locus_tag="AMK34_RS18715"
                     /old_locus_tag="AMK34_18555"
     CDS             6873..7265
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016330823.1"
                     /locus_tag="AMK34_RS18715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_18555"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_038520341.1"
                     /transl_table=11
                     /translation="MTELAIGQVTERTGLSVHALRFYEKEGLLAAPVKRDANGRRVYTE
                     HDVDWLLNCTKFRASGMPLAVIREFAELVRQGPGNEEKRLELLREHQNTVRDRIAELAD
                     CLELISRKVEVYEEHVARGTANELWR"
     gene            7303..7686
                     /locus_tag="AMK34_RS18720"
                     /old_locus_tag="AMK34_18560"
     CDS             7303..7686
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070967 - coenzyme F420 binding [Evidence
                     IEA]"
                     /GO_process="GO:0008150 - biological_process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005163349.1"
                     /locus_tag="AMK34_RS18720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_18560"
                     /product="PPOX class F420-dependent oxidoreductase"
                     /protein_id="WP_073846128.1"
                     /transl_table=11
                     /translation="MTKQLTEFTAQKTILLKTFKRDGTPIGTPINIAVEGDHAYIRTYD
                     AAWKAKRMRNDPRVEIAPSTFRGVPTGEPVNARVRLLDGAEARHAATLLARKHRLLHGF
                     LVPLFHRLKKYKTLHYEVRLDTP"
     gene            7793..8779
                     /locus_tag="AMK34_RS18725"
                     /old_locus_tag="AMK34_18565"
     CDS             7793..8779
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020633041.1"
                     /locus_tag="AMK34_RS18725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_18565"
                     /product="MCE family protein"
                     /protein_id="WP_073846129.1"
                     /transl_table=11
                     /translation="MRSFGAVDPVKVALAGLTTMALGMAAALNADALPVIGGGTTYSAE
                     FSDAGGLRADNDVRIAGVKVGKVSEIDLEGDRVLVSFRVKDAWVGDATSASIQIKNVLG
                     QKYLALDPRGEAILDPGDPIPLRRTTAPYDVLEAFRDLSKTVDAIDVGQLARSFDTISA
                     TFADTPADVRSALDGITKLSGTIASRDRQLRTLVANTRQVSQTLVDRDTEAQRLIQDGN
                     ALLRAISTRQQAIKDLLDGSKRLATALDGIIADNDGQLGPVLEQLDRLTSMLQRNQDSL
                     AKGIAAFAPAIRVLTNVAGNGRWIDGYLCGLVLPTFGPLNEKGCFEK"
     gene            complement(8795..9217)
                     /locus_tag="AMK34_RS18730"
                     /old_locus_tag="AMK34_18570"
     CDS             complement(8795..9217)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005163353.1"
                     /locus_tag="AMK34_RS18730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_18570"
                     /product="hypothetical protein"
                     /protein_id="WP_198941682.1"
                     /transl_table=11
                     /translation="MPEETEEKTVDTATDKASGPGRILVAVYAIFALAATSRAAVQIST
                     KFHEAPLAYALSAFAAVVYLLATVALARRGAGWWRIALIACAVELLGVLTVGTFSLFDR
                     EAFPHATVWSVYGQGYLFIPLVLPVIGLFWLRRTKP"
     gene            complement(9210..9575)
                     /locus_tag="AMK34_RS18735"
                     /old_locus_tag="AMK34_18575"
     CDS             complement(9210..9575)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020633043.1"
                     /locus_tag="AMK34_RS18735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_18575"
                     /product="hypothetical protein"
                     /protein_id="WP_073846130.1"
                     /transl_table=11
                     /translation="MITGFAVTVAICATLVAAWSFVQAARKKLPDNALLAGLAVIEVLL
                     VAQLVIGVVLLIGGGRPGSMATYLAYLIGCLVVLPLGTFWALAERTRASTAILGIACLA
                     IPVMVLRLHEVWAGASA"
     misc_feature    complement(9676..9691)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 23.23"
                     /tool="antismash"
     gene            10001..12544
                     /gene="lanKC"
                     /locus_tag="AMK34_RS18740"
                     /old_locus_tag="AMK34_18580"
     CDS             10001..12544
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016330827.1"
                     /locus_tag="AMK34_RS18740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_18580"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_073846131.1"
                     /sec_met_domain="micKC (E-value: 0.0, bitscore: 1341.9,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 3e-12, bitscore: 43.3,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.6e-08, bitscore:
                     29.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVRYEAYCFADPLFFDEQRETGDAADDFASLLPAPGDGWRTGVR
                     GVWRLLHPVARNLPLQGWKIHVSAGLGNAERVLVKVHEHCVEHAVSYKHLRSRTTLLAR
                     NSKYAPRDGSGKLLTLYPADNNELERVLAALSAKLDGEPGAYILSDLRYGAGPLYVRYG
                     GFAEQWVELDGKRVLAIRKPDGTLVPDKREPTFSVPDWVTIPEFLAPHLAARKSGGADQ
                     FPYQVKSSLHFSNGGGVYLADRKADDERVVLKEARPFAGLDRDEVDAVERLRREHEVLE
                     RLKGIDGIPTAYDRFTVWEHHFLAMEYMPGVSLGNWLARNYPLTRRDTTEADIAAYTER
                     ALALVRRVEAMVGEVHERGIVFGDLHSLNILVDGDDDAVSLIDFEMASDVESGTRPALG
                     APGFRAPRDRNGFEVDEYALAVLKLWIFLPLTTLLELAPAKLRGLADFVQQRFDVPEGY
                     ADSIVAELAPRNVPPLTSATELDQERPDWALVRKQITEAILASATPERTDRLFPGDIEQ
                     FRVGGACFGYGAAGVLHALKAVSGERHPAHERWLLDSIRRDPPGRPGFYDGSYGIAYVL
                     EELGYREEATKLLTASTTLVEQTTDHGLEGGLSGIGLTQLHFAVARKDNEFGRQALATA
                     VRLAEALEIADPPGDFGRAGLLNGWSGPALLFVRLFERTREEGWLSFADQALERDIEEC
                     VESDDGSLQVRDGETRTLPYVGVGSAGILMVAEELAKHRPDAKALKSLPGLREACRGEF
                     VIHPGLLFGRGGLMTALAMGAEPDQRVRDAIDLHLSRLAWYAVPYKGGLAFPGNQLLRL
                     SMDVVTGGAGVLLALAATLDGKAALPFLSSRTAVR"
     misc_feature    10148..10150
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    10349..10351
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            12584..12727
                     /locus_tag="AMK34_RS42700"
     CDS             12584..12727
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009949109.1"
                     /locus_tag="AMK34_RS42700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_123798255.1"
                     /transl_table=11
                     /translation="MELVLDLQALEAPEVLEGGGGGSHGGASNLSLLASCANSTVSLLT
                     CH"
     CDS_motif       12584..12646
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MELVLDLQALEAPEVLEGGGG"
                     /locus_tag="AMK34_RS42700_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       12647..12727
                     /prepeptide="core"
                     /locus_tag="AMK34_RS42700_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="10.40"
                     /molecular_weight="2356.6"
                     /monoisotopic_mass="2355.2"
                     /core_sequence="GSHGGASNLSLLASCANSTVSLLTCH"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MELVLDLQALEAPEVLEGGGG"
                     /leader_location="[12583:12646](+)"
                     /alternative_weights="2374.6"
                     /alternative_weights="2392.6"
                     /alternative_weights="2410.7"
                     /alternative_weights="2428.7"
                     /alternative_weights="2446.7"
                     /alternative_weights="2464.7"
     gene            13008..14675
                     /locus_tag="AMK34_RS18745"
                     /old_locus_tag="AMK34_18585"
     CDS             13008..14675
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020633046.1"
                     /locus_tag="AMK34_RS18745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_18585"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_073846132.1"
                     /transl_table=11
                     /translation="MAGSADRLLVTVTALDRPRLIALIFSALAGTAAGLLLPGALAAAV
                     DAVVAGRPSLPEVTWLIVLGVTEIAVGLIGGILTARMTASATAWLRRKLADRYLALGTR
                     STFADGDAISRLTGDCTGAGLVASVVVQLGSTTLISGGAVVLLALMDWRLALVFLGSIP
                     FGLMLARTHLKNTADDVLTYQEVSGELAARMVDAVAGLRTIAASGTADREADRVLRPLP
                     KLSLAGRGMWRTQARMVWRSGLLLPAVELAVLAAAGFGVLEGRLTVGQVLAALGYVALG
                     MGLITQIPLLTTLSRARSCARRITEVLEAPVPEPGDLGVVPGRGTLELRGVTVEGALRD
                     VDLLVRGGRFTAVVGRSGSGKSALVNVLGGLLTPDEGTATLDGRPLEKLRPYELRAVVG
                     FAFERPALLGATIGDAVGYGSWAGEAAVRAACRSAQVDDLIVRLPDGYRTPLRETPLSG
                     GEAQRIGLARAIAHAPRVLILDDATASLDTVTEAAVEEAIERTLPGRTRVVVTHRAATA
                     SRADTVVWLEDGRVRAVGAHDELWRTPAYRAVFTEGAQ"
     gene            14672..16408
                     /locus_tag="AMK34_RS18750"
                     /old_locus_tag="AMK34_18590"
     CDS             14672..16408
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030767.1"
                     /locus_tag="AMK34_RS18750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_18590"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_038520334.1"
                     /transl_table=11
                     /translation="MSVWGLYRSALAGQWRGGLVLLACSVLESAPAFLSGRLVELAVDE
                     GFAADRPGTGLRWLAVFGLVAVIGAFGSRLVWHQLGKVVEPLRDALVTAVVRGVLHDPA
                     PPRNQPDASGVARITQHVEVVRDATAGLLVQARGMIVTTVAALAGLFTVAGSLALIVAI
                     PVVVSVLVFACLLPSLARRQRALALADERTAEVAGASLSGMRDIVACGAEPLAALELYD
                     AIDTQAKAAVRVARSGAARTVVIATGGFVPLLLALLVAPGMVQAGVLTAGAALGALVYL
                     ATTMQPALRGLAATASTVVLRLIVALRRLAETAEAEPEADGTAEPDGTAIYVRDLTFSW
                     GAAAQPVVRGLDLHLRPGERLAVVGPSGIGKSTLAGLLTGMLTPQAGRVLLGGVPVREV
                     PAALRHRMVALIPQEAYVFAGTVRDNVGLFAQTAMDGELLAAVRAVGAEPLVTRLGGLD
                     GEIGHGTLSAGEAQLIALARVYASDATVVILDEATSHLDPPAEARAERAFAERGGVLVV
                     IAHRLTSALRADRVLVMDGKETALGTHLELMDRSTRYAQLMHAWSPRLPQPSAQFFQRA
                     PE"
     misc_feature    16364..16366
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(16364..16783)
                     /locus_tag="AMK34_RS18755"
                     /old_locus_tag="AMK34_18595"
     CDS             complement(16364..16783)
                     /EC_number="3.1.2.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 4HBT_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016330831.1"
                     /locus_tag="AMK34_RS18755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_18595"
                     /product="thioesterase family protein"
                     /protein_id="WP_073846133.1"
                     /sec_met_domain="4HBT_2 (E-value: 5.5e-16, bitscore: 56.0,
                     seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVNAEYPHWQTVPLRWKDNDVYGHVNNVVHYSVMDTVINTWLIER
                     GRLDIETGEVIGLCVESQCKYHASVSFPGELEVGLRVGHLGRSSVRYEVGMYSKETVIA
                     EGHFVHVFVDRESRRPVPVEGLLRSALEELRTGLG"
     gene            complement(16777..18009)
                     /locus_tag="AMK34_RS18760"
                     /old_locus_tag="AMK34_18600"
     CDS             complement(16777..18009)
                     /EC_number="1.1.99.24"
                     /GO_function="GO:0004022 - alcohol dehydrogenase (NAD+)
                     activity [Evidence IEA]"
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0047988 - hydroxyacid-oxoacid
                     transhydrogenase activity [Evidence IEA]"
                     /GO_process="GO:0006629 - lipid metabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020642937.1"
                     /locus_tag="AMK34_RS18760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_18600"
                     /product="hydroxyacid-oxoacid transhydrogenase"
                     /protein_id="WP_038520332.1"
                     /sec_met_domain="Fe-ADH (E-value: 1.7e-103, bitscore:
                     343.1, seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYGTGSSDEIGYDLTQYGARRVLVLTDAGVAATGWPQRIAEGIE
                     TYGIEAVVFDGVHVEPTDVSMRKAVDFARGQGEWDAFVAVGGGSAIDTAKAVNLLTSND
                     GDLMDYVNAPVGGGRAPSAPLKPLVAVPTTTGTGSESTTVCVLDVLSLRVKSGISHLRM
                     RPSLAVVDPRLTVSQPPEVTAASGMDILCHAAESYTAKPYTEFDRKRPEDRVPYCGSNP
                     LADMFAEQSLRLLSWALPAAVRDGSDMKAREAMALAATFAGLGFGNAGVHIPHANAYPI
                     AGQVRDFHPSGYPGDEAMVPHGMAVSLTAPAAFRFTFDAAPERHIRVARLLAPDYEWPG
                     DLRDHLPAVLGQIMREIGIPNGIGAVGYTESDVDSLVSGTVKQQRLLATAPREASEADL
                     AVILRESVTLW"
     misc_feature    complement(18028..18039)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.05"
                     /tool="antismash"
     misc_feature    18176..18192
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.81"
                     /tool="antismash"
     gene            18181..19842
                     /locus_tag="AMK34_RS18765"
                     /old_locus_tag="AMK34_18605"
     CDS             18181..19842
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016330833.1"
                     /locus_tag="AMK34_RS18765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_18605"
                     /product="thiamine pyrophosphate-dependent enzyme"
                     /protein_id="WP_255355312.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 6.7e-38, bitscore:
                     126.9, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.8e-34, bitscore:
                     115.6, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRYQPGASVAQTAVRILTEAQIHRVYAVVGESFLDLLDALQRERS
                     ITFVSARHDSGAAFMAEAEGKLTEHPAVLLAGRGPNAANLAIGVSTAYQDESPMVVLLE
                     NPPQDPGPTSELPTADLTAMFEPISKWTGRAESPDEVPGLLVEALTRCREGRPGPTVVA
                     VPADFWGVPFDSAKPVASVRPPATGALGRTAEAVAQLVDEARYPVVIVGGRARAARDEL
                     IAVADELALPVYNAFRRQDAFPENHARYAGHLGIGIPARQLDALERADLVLALGTQLDE
                     VTTQSFRYPTPSQTLVLVGTGIEPARRGGLTFRVDSEVEPFLRELRNVASPRQRRASAA
                     NAAVHTFMTPPDTSGATRVHPADVIRAVRKLAPEDAIVTSDAGNFAQFMHRYWCFTAPR
                     SQLGPSNAAMGYAVPAAVAAKLAEPRRTVIAMAGDGGALMTGQEIETAVRYRVPVTVLV
                     FQNGLHGPLAVHQARKHGRLSGVTVPVTDFASWARGLGAAGYTVDDREELEPIIASALV
                     RQRPCVIDIRTDPDVVTPDIRLTSLLGASRQQQGGQ"
     gene            20102..20272
                     /locus_tag="AMK34_RS43195"
     CDS             20102..20272
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005163371.1"
                     /locus_tag="AMK34_RS43195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_162836881.1"
                     /transl_table=11
                     /translation="MADEAKPQDKSVSGVVPVLFSADAETHDIAVVATNREALRRSPFG
                     NEAPLRAASGE"
     misc_feature    20466..20481
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.51"
                     /tool="antismash"
     gene            20536..20739
                     /locus_tag="AMK34_RS18770"
                     /old_locus_tag="AMK34_18610"
     CDS             20536..20739
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0001072 - transcription antitermination
                     factor activity, RNA binding [Evidence IEA]"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1255: cold-shock
                     DNA-binding domain protein"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013222289.1"
                     /locus_tag="AMK34_RS18770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_18610"
                     /product="cold-shock protein"
                     /protein_id="WP_005163378.1"
                     /transl_table=11
                     /translation="MTQGTVKWFNSEKGFGFITPDNGGGDVFVHYSEIKGNGFRTLEEN
                     ARVEFEIGQGAKGPQATSVTVI"
     gene            complement(20809..21471)
                     /locus_tag="AMK34_RS18775"
                     /old_locus_tag="AMK34_18615"
     CDS             complement(20809..21471)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015104840.1"
                     /locus_tag="AMK34_RS18775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_18615"
                     /product="response regulator transcription factor"
                     /protein_id="WP_073846134.1"
                     /transl_table=11
                     /translation="MTTVFIVDDQALVRESFASLLNAQPGLDVVGQAGDGIEALAGISA
                     LATRPDVVLMDIRMPVMDGIEATRRLLEGDDAKPKVIVLTTFHLDDYVYEALRAGASGF
                     LLKDAPSAELINAIEVVAAGEALLSPAVTKRLIANFVATAPVPRPSPARFDVLTERERE
                     VLRLIAKGRSNPEIAADLVLSAQTVKTYVGRILAKLGVRDRAQAIVLAYEAGLVSPA"
     misc_feature    complement(21583..21596)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.31"
                     /tool="antismash"
     misc_feature    complement(22042..22056)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     misc_feature    complement(22232..22247)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 22.47"
                     /tool="antismash"
ORIGIN
        1 gtcgaggtgc gcgacgagga aggcaggccg gtgtcctatc ggatcggctc ggagcccgac
       61 gcgcacgggt gagcgaggcc ggccggggac tctgaactat ccgcgctcgg cgcggcgccg
      121 ggcgagttcg ccgacaacgc gttgccacgc aggggaagcc tcggagacac gggaaaccac
      181 cagctcgccg taccccggac ggccaccccg ccgctcgtgt tcgaccgccc aggcgtccag
      241 gtcgtcgatg agcgcgtcca ggcgcggatc acgcgggtcc catccgacgg cctgatcgca
      301 cgcgaggtac acgcggagcg tctcgggatc gtcgaaggcg gcgttcttct cccgcacccg
      361 ttccggtacg gcgcggggat ccagcgcccg catcaggatc catgcgtcgc gttcgagcag
      421 cacccgctgc tcgctgacgc cgaggccgcg catccgctcc agcaaggcga ccacgtcggg
      481 cggcaggacg agccgctcgc cgccggtcag ttcggcgatc cggagccggt tttcggcgag
      541 ccggtcgatc ttgcgccgga gttcggcgtc gatgtcggaa atggcggcgg cgaactcggc
      601 gggttccgcg tgcagcagcg cgtcgacgcg ggccagcggg accccggcgt cggcgagggt
      661 cctgatccgg atgaggtcca ccgccgcttg cgcggtgtag cggcggtaac cggaggcgtc
      721 ccgttcgggc tcgggcagga ggccgatgtg gtggtagtgg cggacggtgc gcacggtcac
      781 gcccgcggtc gccgcgagct ggccgatcgt gagcacccgt cctcctcttc ttgagcctaa
      841 atgccgtcga cgacgtcgcg gatcgcctgg accaccgcgt cagggcgatc gaagcagagc
      901 cgatgatgca gtgtgtcgtt gaggacgcgt tgctcccctc gggagaaccc gccgacccgg
      961 gccgcgtcca tcttcagctt ggcctcgtcg atctcctgcg gcggatgcgc gacgacggtg
     1021 agcgcgatcg ccgggacgtc gggcagctcc ggcccggctc gcagttcggt ggcgagcgcg
     1081 accaggccgg tgcgctccgc ggcgccgatg cgcagccact cgtcgctcac cttggcgtcg
     1141 acgagcgcct cgcgcacgtc ttccgggtag tcctcgcgca gctcggcgta catcgcgcga
     1201 agggcggcgc gatccggacc gggtgacggc cgcccggccg ccgacaggct cgcctcgggc
     1261 ggcatgaagt cgtcccagtc gggatggagg gcgtccagga agaccagccc ggccacgtcg
     1321 cgcggataga gctgcgcgaa ccggtgcgcg tagaggccgc cgagcgagtg cgccgccagc
     1381 acgtacgggg cgggaatgtc caggctgacc agcagctcgc gcagttccga ggcgaccgcg
     1441 gcggcggtgc ggggcagggg gagggcgtcg ctgtggcccg tcccgccgcg gtcgtacacc
     1501 acggcggtgg tgaaccgcgc gacctcctgc tggacgccga agtagtcgag gccgaccgca
     1561 ccggcgcccg gcaagaacac gacggcgggc ccaccttcac ccgatcggtg cacgaaaagg
     1621 cggtgctcgt cgatctcctg gagtcctccg acagggggtg tgttcgtcat gcggcaaggc
     1681 tccgaccctg acgcagggtc aaggtcaagc ggccgggaag gtcgacgctg acctggggaa
     1741 atgacccggt tcgggatggc agcgtgtgca aacgggcaag acctgcgaca atggacggcg
     1801 agatcggggc atcgaatggg ctcagactcg ctatgaagag caggtaaaaa agtatggctc
     1861 agggcagcgt taagtggttc aacggcgaaa agggcttcgg cttcatcgct caggacgacg
     1921 gcggaccgga cgttttcgtg cactactcgg agatccaggg cagcggtttc aagtccctgg
     1981 acgaggggca gcgcgtcgag ttcgagatcg gccaaggtca gaagggcccg caggcccagc
     2041 gcgtcgtcgc catctgactt tcttcacgcc gaaggcctcc atccgtaccg ggtgggggcc
     2101 ttcgggcgtt tcggctaccg atatcgtcga agcatgcttg tgatcgttcg tgagcacccg
     2161 tgcggccgga cgcggtgagc cgctccgccc tggagcccga gcaggtcggg cggaaggtgc
     2221 ggttgcgcga ggtcggcctc cgggaccgcc gggtcctgat gggcttcgac cgcgacatgg
     2281 cccgcgaggc gacgccgctg atcggcggcg ggcaccggca ctgggcttcg caccgttcgg
     2341 ggtccgccgg cgacgacatc cacttcggta tcgagaccgt gcgcggccgc atgctggtcg
     2401 gctcggtctg caccatcggc gccgacccgg cgaccggccg gttcggctac ggcatcggga
     2461 tcgcgccgcg ccaccagcgc tgcggctacg ccacggacgc catcaccgtc ctgctggcgc
     2521 atatgttcgg acagcgcggc ttccgcaaat gcgaggtcag cgtctacggc ggcaacctcg
     2581 cgtcgctctc gctgcacggc ggcctcggct tccgcgagga aggcaggctg cgcgacaccg
     2641 aagtcgtgcg cggcgagatc aagtatctgg tgcggatggg catcacggcc gaggaattcg
     2701 ccgcgcggcc tctggacgcc ctcggtgatc tcggcaggcg tggccagcac cggcggcccc
     2761 gccgcggcaa gcactggcgc gcgcccgccg cggtcagcgg ctgatcagcc cggattcgta
     2821 ggcgaacacg accgcctgga cgcggtcgcg gaggccgagc ttcgtgagga tgcggccgac
     2881 gtgcgttttc accgtccccg gtgagaggaa cagcagttcg gcgatctcgg cgttggacag
     2941 gcccctggcc agctgctgca gcacctcgtt ctcccgtccg gtgagcaggg cgagccggtc
     3001 gtccggcggc gccgcgggca ggccggtgac gacgcggtcg agcagccgcc gggtgacggt
     3061 cggcgcgaga gtggcctcgc cggaggcgac cacgcggacg ccggagagca gatccggcgc
     3121 cagcgcgtcc ttgagcagga agccgctggc cccggcctgg agcgcggcgt agacgtattc
     3181 gtccaggtcg aacgtggtca gcaccaggac gcgggcacgg tgggccgcgg cgatcgcggc
     3241 ggtggcctcg acgccgtcca tctcgggcat ccggatgtcc atcagcacca cgtccggatc
     3301 gaggtccgcc accagcgcga cggcctccgc cccgtcaccc gcctcgccga cgacgtcgat
     3361 gtcgtccgcg ttgtccagga tcatccgcag gccggtgcgc acgagcgact ggtcgtcggc
     3421 gatgaccacc cggatggtca tgacggcagg gtcgcgcgga cgacgaagcc gcgctccgga
     3481 cgcggtcccg cgtcgaaggt gccgcccagg acgttcaccc gctcacgcat gccctcgagg
     3541 ccgtgcccgg cgccggacgg ctcttccgtc gcgatgccgt cgtcggtcac ttcgatctcc
     3601 agcgtctcgg gcccataccg catcacgata gtcaccgacg ccgccggacc ggcgtgtttc
     3661 aggacgttcg tcagcgcttc ctgcacgatc cggtacgccg ccaagtccac tgtggacgaa
     3721 agcgggcggg gttccccttc gaccaggaac tcgaccggcg tccccgcgga acggatgtcg
     3781 gcggccagcc gcggcaggcg ttccgcgccc ggctggggct cccaatcggg ctcgtcctgg
     3841 ccgagcgcgc cgagcaggcg ccggatctcg cccaacgcgg tccgcccggt gccgacgatg
     3901 gcgtcgagcg cttcccgcgc ccgttccggc cgccgttcca gttcggcttg ggcgccctgc
     3961 gcctgcaaca ccaccacgga aagcgcgtgc gcgacgacgt cgtgcagctc gcggctgatg
     4021 cggccgcgtt cggcggccac ggccagcgcg gcctgggtgt cccgctcgcg ttcgaggtcg
     4081 gcggcccgct gttccagcac cgaaaggcgg atccggcgct gccgtgtgtt cagcccggcg
     4141 agccacgcca ccgcgagcga caacccgatg ccggcgaaac cgccccagtc ctgcacctgg
     4201 tcgtcttcgg gtccgggagg tgccagccga tcgatgatga tgatccgcgg cggtggcgga
     4261 gccggttccc gcgtattcgc gtcggcggcg tggatcgccc acgctccggc gaccagcagg
     4321 ctcgccgcca gcagggcgaa cgaaagtcgt cgcgaccccc acgccgcgac ggagaagagg
     4381 ccgatcaagg ccacgacgtc gaccgggcga agatcgttgc ccatggccag atgcaggagt
     4441 gagacggtcg cgccggtcgc gaaggtgatc gtgggattgc ggtgccggac gagcagggaa
     4501 gccaaggaca ccaaggaggt cagccaccag tcgaagccct ccggatcgtc ggccgagacc
     4561 acagtggaca gtccgatgag cacggtcagc ccgatgtcca cggctttcgg gtggttcctg
     4621 aggaaggaga gcaccggccg agcgtaatcc cggatcgggg cctcgcggat ccctctcgcg
     4681 acagacatcg ggatacgacc tgcggcagac gcgcgaatac ggcggcgggt cccaggctgg
     4741 acgcaggaag atccccgaca gaaacggaat cctcatgaga aggcttctcg tcgcgctggt
     4801 cgccctcgcc ggcatggtgt ccttggcgag cccggccgcg gcggctccac gactgaagtt
     4861 gccgccgccg accggctcgc atcccgtcgg ctccagcgat ctgcatctga tcgactcttc
     4921 gcgcaaggac ccctgggtgc cgaccgggcc gcgcgagctg atggtgtcga tgttctaccc
     4981 cgcgctggtg ccgttcggcg cgaaacggcc ctacctcacc tcggccgagg cgaaggcgtt
     5041 cctgaccgaa tcgggcctgc ccgacgtcga ccccgggctg ctctccgggc tccggaccag
     5101 cgccagggtc gacgccccgc cgctgccggg gaggcacgcg ctcgtcgtcc tgtcgccggg
     5161 attcggcaaa ccgcgcacca cgctcaccgg cctggcggaa gacctggcga gcaagggttt
     5221 cgtggtcgcg ctgatcggcc acaactacga gtcccacggc accgcgttcc ccgacgggca
     5281 cgtcaccgaa tgcgccgcct gcggatccga ttccatgttg ctcccgccga tccgctccgc
     5341 ggacgtctcc ttcgtgctcg acaccctgac caagccttcc tcgcgctggg cccggctgat
     5401 cgaccggacg cggatcggga tggcgggcca ttccatcggc ggctacagtg cgccgaccgc
     5461 gatggtcgac gaccagcgga tccgggcggg cgtcgacatg gacggcaggc tgtggtcgcc
     5521 gatccccgcg tccggtatcg accggccgtt cctgctgctc ggccgcgaaa gcgagtacac
     5581 cccggccggc ccggacacga cctgggcggg cagctggccg aacctcaccg gctggaagcg
     5641 ctggatcagc gtcgcgacgg ccgggcacgc gtccttcacc gacgtcggcg tcctcggtga
     5701 acagctcggc ctgaccaagc ccggcctgct cggtggcgag cgcggaatgc agctgaccag
     5761 ggcgtacgtc tcggcgttct tcgacgcgaa cctgcgcggc gggcaccagc cgttgctcga
     5821 cgggccggtg gcggacaacc cggagatcaa gttctggaac tagccgaggg ggaccccggt
     5881 gaggccggcg gagaacttcc acagccgctc ggcctcaccg gcgtcgatcg cgtacgggcg
     5941 cacgccgacc cactcgccct cctcagcggc gatctcggcg acgtcgcagt cctcgcagta
     6001 gagcccaccc agtccatcga gccgcggcga cgtcgccgcc cagacctggg tggccgcgcc
     6061 ctgctccggc gatttgaact ccgggtcggc ctggttcccg tgctcgtcga tccagccgcg
     6121 ctcgaccatc tcctccggcc gcagatgccg ctggagggga gtgaggatgg cgcccggatg
     6181 caggctgaac gcgcggatcc cgtgttcggt gccgagcttg tccaggtgca cggcgaacag
     6241 cacgttcgcc gtcttggcct ggccgtaggc gagccagcgg tcgtagccgc gctcgaactg
     6301 gacgtcgtcc cagcgcatcg gcgacgagtg atggccggac gaggccaccg tgacgacgcg
     6361 cgcgccgccg ccggccttca gcgcgggcca aagccggttc accagggcgt ggtgaccgag
     6421 gtggcagatc gcgaaatgcg actcccagcc ggggccgacc cgccgttccg gcgcggccat
     6481 gatcccggcg ctcgcgatca ggatgtcgat cgggcggccg gtgccgagga agcggccggc
     6541 gaaggactcg acgctcgcca gatcggccag gtcgagctcg ccgacctcgg tgccggggat
     6601 cccggcgagg gcggcctcgg cgtcggccgg acggcgcgcg gggacgacga catgcgcgcc
     6661 ggcgttcgcc agtgcccgcg tggtttccaa gcccagtccc gaatatccgc cggtgacgag
     6721 ggcgagcctg ccggagaggt cgatgccgtt cagtacttct tcggccgtgc tgcgcgggcc
     6781 gaagccggag ccgatcttgt gttgtgcggt ggtcatgagg cggacgctaa gagctagagg
     6841 gctctctagg tcaaggcgct atcgtcggtc cggtgacgga actcgcgatc ggccaggtca
     6901 ccgagcggac gggcctcagc gtccacgcgc ttcgcttcta cgagaaggaa gggctgctcg
     6961 cggcaccggt gaaacgggac gcgaacgggc gccgcgtgta caccgaacac gacgtcgact
     7021 ggctgctgaa ctgcaccaag ttccgggcgt ccggaatgcc gctcgccgtc atccgcgaat
     7081 tcgccgaact cgtccgccaa gggccgggaa acgaggaaaa gcggctcgaa ctgctgcggg
     7141 aacaccagaa caccgtccgc gaccggatcg ccgaactggc cgactgcctg gaactgatca
     7201 gccggaaggt cgaggtctac gaggagcatg tcgcgcgggg gaccgcgaac gagctctggc
     7261 ggtagcccgt cacgtttcgc gtggcggctt cgtcctcatg acatgactaa gcagctcacc
     7321 gaattcaccg cccagaagac gatcttgctg aagaccttca aacgggacgg gacacccatc
     7381 gggacgccga tcaacatcgc cgtcgaaggc gatcacgcgt acatccggac gtatgacgcg
     7441 gcgtggaagg ccaaacggat gcgcaacgat ccgcgggtcg agatcgcccc gtcgacgttc
     7501 cgtggcgtcc cgaccgggga gcccgtgaac gcgcgggtcc gcctgctcga cggcgccgag
     7561 gcgcggcacg cggccaccct cctggcgagg aaacatcggc tcttgcacgg cttcctcgtc
     7621 ccgctcttcc atcggctgaa gaagtacaag acgctccatt acgaagtccg gctcgacacc
     7681 ccttagcgtc cacagtggac agacgttgcc acccgatcgg tgcaacgttt cgcctggcga
     7741 tgggcaagag cggcccctaa gctttgccgc tcgtgacctg cgaggtgaga cgatgaggtc
     7801 cttcggcgcg gtggatccgg tcaaggtggc gctcgccggg ctcaccacga tggccctcgg
     7861 catggcggcg gcgctcaacg ccgacgcttt gccggtgatc ggcggcggca cgacgtattc
     7921 cgccgaattc tccgacgcgg gcggactgcg cgccgacaac gacgtccgga tcgccggggt
     7981 gaaggtcggc aaggtttccg aaatcgacct cgaaggcgat cgcgtgctcg tctccttccg
     8041 ggtgaaggac gcctgggtcg gcgacgccac gagcgcgtcc atccagatca agaacgtcct
     8101 gggacagaag tatttggcgc tcgacccgcg tggcgaagcg atcctcgatc ccggagaccc
     8161 gatcccgctg cggcggacca ccgcgccgta tgacgtcctt gaagcgtttc gggatttgtc
     8221 gaaaaccgtc gacgccatcg acgtcggcca actggcgaga agcttcgaca cgatttcggc
     8281 gactttcgcc gatacgcccg ccgacgtccg ctccgcgctc gacgggatca cgaagctctc
     8341 cggcaccatc gcttcccggg atcggcagct ccggacgctc gtcgcgaaca cgcggcaggt
     8401 ctcgcagacc ctcgtcgacc gcgacaccga ggcccagcgg ctgatccagg acggcaacgc
     8461 gctgctgcgc gcgatctcca cccggcagca ggcgatcaag gacctgctcg acggctcgaa
     8521 acggctcgcg accgcgctcg acggcatcat cgccgacaac gacgggcagc tggggccggt
     8581 gctcgaacaa ctcgaccggc tgacgtcgat gctccagcgc aatcaggatt cgctggccaa
     8641 ggggatcgcc gcgttcgcgc cggcgatccg ggtgctcacc aacgtcgcgg gcaacggccg
     8701 ctggatcgac ggctacctgt gcgggctggt cctgccgacg ttcggcccgc tcaacgaaaa
     8761 aggctgcttc gagaagtgag cggcacgctg tccgtcaggg cttcgtccgc cgcaaccaga
     8821 acaacccgat caccggcagc accagcggga tgaagaggta gccctgcccg tacaccgacc
     8881 acacggtggc gtgggggaag gcctcgcggt cgaaaaggct gaacgtgccg acggtcagca
     8941 cgccgagcag ttcgacagcg caggcgatca gcgcgatccg ccaccagccc gcgccgcggc
     9001 gggccagcgc cacggtggcc agcaggtaga ccacggccgc gaacgcggag agggcgtagg
     9061 ccagcggggc ttcgtggaac ttggtgctga tctgcacggc ggcgcgcgag gtcgccgcca
     9121 gcgcgaagat cgcgtacacg gcgaccagga tccgtcccgg gccggaggcc ttgtccgtcg
     9181 cggtgtccac cgtcttctcc tcggtttctt caggcactgg cgcccgccca cacctcgtgc
     9241 agccggagca ccatcaccgg gatggcgagg cacgcgatgc cgaggatcgc ggtgctcgcc
     9301 cgggtgcgct cggccagcgc ccagaacgtc ccgagcggga gcacgaccag gcagccgatc
     9361 aggtaggcga gataggtggc catgctgccg gggcggccgc cgccgatcag caggacgaca
     9421 ccgatcacga gctgggccac caggagcact tcgatcacgg cgaggccggc gagcagtgcg
     9481 ttgtccggca acttcttgcg cgcagcctgg acgaaactcc acgccgcgac cagcgtcgcg
     9541 cagatcgcga cggtcaccgc gaaccctgtg atcacgtcgg cctccttacc cgctccaccg
     9601 gcgacaacgt acctccgggc cgatcatcgc cgacgggcga ccggtgggcc gcgtggcggg
     9661 cgccacgggc ccggcagtgg tccagacctc gggtgaatag atcacgaaac gcggccggtt
     9721 ggcgcactgt caatttcctt gcgcattatt gcgttcggtg cctcgacctg ggattacggc
     9781 accggtgcgt tcctgttaca caccgaccgg gtggttggaa tccgagttga tctcacgctg
     9841 ggtaccccta ccattcggta gttttcgaat tcacgtccct gaacagccca tccgaacccc
     9901 cgatatggcg gattggccgt tcggggtccg gcgggtggaa tattctgcat cgcgatggtg
     9961 cacatggccc atccgattgg tgccaaggag ggggcgctcg atggacgtcc ggtacgaagc
    10021 gtattgcttc gccgatccac tgttcttcga tgaacagcgg gaaaccgggg acgccgccga
    10081 cgatttcgcc tccctgttgc ccgctcctgg ggacggctgg cgcaccggag tgcgcggagt
    10141 gtggcggtta ctgcaccctg ttgctcgaaa ccttcccttg cagggctgga aaatccacgt
    10201 atcggcaggt ttgggcaacg ccgagcgggt gctcgtgaag gtgcacgagc attgtgtcga
    10261 gcacgccgtg tcgtacaagc atctgcgttc gcggacgacc ctgctggcca ggaattcgaa
    10321 atacgctccg cgtgacggaa gcggtaagtt actgactctt tatccggctg acaacaacga
    10381 gctggagcgt gttctcgcgg cgttgtcggc gaagctcgac ggcgagcccg gcgcgtacat
    10441 tctcagtgat cttcggtatg gtgccggccc gctctacgtc cgctacggcg gattcgccga
    10501 gcaatgggtc gaactcgacg gcaagcgggt cctcgcgata cgcaaaccgg acgggacgct
    10561 ggtcccggac aagcgcgaac cgaccttctc cgtacccgac tgggtgacga ttccggagtt
    10621 cctcgcgcct catctcgcag ctcgcaagag cggcggagcg gatcagttcc cctatcaggt
    10681 gaaaagttct ctgcacttct ccaacggcgg cggcgtgtac ctcgccgacc ggaaggccga
    10741 cgacgaacga gtggtcctca aggaggccag gccgttcgcc ggcctggacc gcgacgaggt
    10801 cgacgccgtc gaacgcctcc gccgtgagca cgaggtgctg gagcggctga agggcatcga
    10861 cggcatcccc accgcctacg accgcttcac cgtctgggag caccacttcc tggcgatgga
    10921 gtacatgccc ggcgtctcgc tcggcaactg gctggcccgc aactacccgc tcacccggcg
    10981 cgacaccacc gaggccgaca tcgccgcgta caccgaacgc gcgctggcgc tggtccggcg
    11041 ggtggaggcg atggtcggcg aggtgcacga acgcgggatc gtcttcggcg acctgcactc
    11101 gctgaacatc ctcgtggacg gggacgacga cgcggtctcc ctgatcgact tcgagatggc
    11161 ttcggacgtc gaaagcggca cccggcccgc gctcggcgcg cccggcttcc gcgcgccgag
    11221 ggaccggaac gggttcgagg tcgacgagta cgcgctcgcc gtcctgaagc tgtggatctt
    11281 cctgccgctc acgacgctcc tcgaactcgc cccggcgaaa ctgcgcgggc tcgcggactt
    11341 cgtccagcag cgcttcgacg tcccggaggg ctacgccgac tcgatcgtcg cggagctcgc
    11401 accccggaac gtgccgccgc tcacgagcgc caccgagctg gaccaggaac gaccggactg
    11461 ggcgctggtc cgcaagcaga tcaccgaggc gatcctcgcc agcgcgaccc ccgagcgcac
    11521 cgaccggctc ttccccggcg acatcgagca gttccgcgtc ggcggagcgt gtttcggcta
    11581 cggcgcggcc ggcgtcctcc acgcgttgaa agcggtcagc ggcgagcggc atcccgcgca
    11641 cgaacgctgg ctgctggact cgatccgccg cgatccgccc ggacggccgg ggttctacga
    11701 cggctcgtac gggatcgcat acgtcctcga agagctcggt taccgcgaag aggccaccaa
    11761 gctcttgacg gcgtcgacga cgctggtcga gcagaccacc gaccacggtc tggaaggcgg
    11821 cctgtccggg atcgggctca ctcagctgca tttcgcggtt gcccgtaagg acaacgagtt
    11881 cggcaggcag gcgctcgcca ccgccgtccg gctcgccgaa gcgctcgaga tcgccgaccc
    11941 gcctggcgac ttcggccgcg cagggctgct caacggctgg tccggtccgg cgctgctgtt
    12001 cgtgcggctg ttcgaacgca cccgcgaaga aggctggctg tccttcgccg accaggcgct
    12061 ggagcgggac atcgaggaat gcgtcgagtc cgacgacggc tcgctgcagg tccgcgacgg
    12121 cgagacccgg acgttgccct acgtgggtgt cggcagcgcc gggatcctca tggtcgccga
    12181 ggaactggcg aagcaccgtc ccgacgcgaa ggcgctgaag agccttcccg gcctgcgtga
    12241 agcgtgccgc ggcgagttcg tcatccaccc cgggctgctg ttcggcaggg gcgggctgat
    12301 gaccgcgctg gccatgggcg ccgaaccgga ccagcgcgtc cgcgacgcca tcgacctgca
    12361 tctttcccgg ctggcctggt acgcggtgcc gtacaagggc ggcctggcgt tccccggcaa
    12421 ccagctgctg cggctgtcga tggacgtcgt caccggcggc gcgggcgtcc tgctcgcctt
    12481 ggccgccacc ctggacggga aggccgcgct gcctttcctg tcctcccgaa ctgccgtccg
    12541 atgaggacgg cggaccaaga ggtaactagt gaaagggaac accatggaac tggttctcga
    12601 cctgcaggcc ctggaagccc ccgaggttct cgaaggtggc ggcggtggca gccacggcgg
    12661 cgcgagcaac ctcagcctgc tggcctcctg cgcgaacagc accgtcagcc tgctgacctg
    12721 ccactgagtc acggctgagc actgaaggcg cgggagcggc acaggccaag tgcgccgctc
    12781 ccgcgtcttc attttgcctt ccggttcatc tcgttgggat cacggtgtga ggagtgggag
    12841 gcggagctga ggtcgcgccg ccttgatcag cccgaacgcg accccgcccg gccggaggcc
    12901 ccgctatcgc ggtggcaggg cactctgttc gcccacctcg gcatttcgtg tcaacggccc
    12961 tgccgacgtc gatcgcggtc gcggggtcac caggactaag gagtgggatg gcgggttccg
    13021 ccgatcggtt gctggtcacg gtgaccgcac tggatcgccc ccgcctgatc gcgctgatct
    13081 tcagcgcgct cgccgggacg gcggcggggc tgctcctgcc cggcgcgctc gccgccgcgg
    13141 tcgacgccgt cgtcgccgga cggcccagcc tgcccgaggt cacctggctg atcgtcctcg
    13201 gcgtcaccga gatcgccgtc ggcctgatcg gcggcatcct caccgcgcgg atgaccgcgt
    13261 ccgcgaccgc ctggttgcgc cgcaaactcg ctgaccgcta tctcgcgctc ggcacccgat
    13321 cgaccttcgc cgacggtgac gcgatcagca ggctcaccgg tgactgcacc ggcgcgggac
    13381 tggtcgcctc cgtcgtcgtg cagctcgggt cgaccaccct catctccggt ggggccgtcg
    13441 tcctgctcgc gctgatggac tggcggctcg cgctcgtctt cctcggcagc atcccgttcg
    13501 gcctgatgct cgcgcgcacc cacctgaaga acaccgccga cgacgtcctc acttatcaag
    13561 aggtgtccgg cgagctcgcg gcgaggatgg tcgacgccgt cgccgggctc cgcacgatcg
    13621 ccgcgtcggg caccgccgac cgcgaagccg accgtgtgct gcggccgctg ccgaagctga
    13681 gcctcgccgg acgcgggatg tggcgcacgc aggcccggat ggtgtggcgg tccggtctgc
    13741 tgctgcccgc ggtcgagctc gcggtgctcg ccgccgccgg tttcggcgtg ctggaaggca
    13801 ggctgaccgt cggccaggtc ctcgcggccc tcggctacgt cgccctcggc atgggcctga
    13861 tcacgcagat tcccttgctc accacacttt cccgcgcgcg gtcgtgtgcg cgacggatca
    13921 ccgaggtgct ggaggcgccg gtccccgaac cgggtgacct cggcgtcgtc cccgggcggg
    13981 gcacgctcga actgcgcggc gtcaccgtcg agggcgcgtt gcgcgacgtc gacctgctcg
    14041 tgcggggcgg ccggttcacc gcggtcgtcg ggcggtccgg ttcggggaag tccgcgctgg
    14101 tcaacgtcct cggtgggctg ctgaccccgg acgaggggac ggcgacgctc gacggccgtc
    14161 cgctggagaa gctgcggccg tacgagctcc gcgcggtcgt cgggttcgcc ttcgagcggc
    14221 ccgcgctgct cggcgcgacg atcggcgacg ccgtcggcta cggctcgtgg gccggggagg
    14281 ccgccgtgcg cgccgcctgc cggtccgcgc aggtcgacga cctgatcgtc cggctgccgg
    14341 acggctaccg gacgccgctc agggaaaccc cgctctccgg cggggaggcg cagcggatcg
    14401 ggctggcgcg cgcgatcgcg cacgcgccgc gggtgctcat cctcgacgac gccaccgcca
    14461 gtctcgacac ggtcaccgaa gccgccgtcg aggaggcgat cgaacgcacg ctgcccggca
    14521 ggaccagggt ggtggtgacg catcgcgcgg ccaccgcgtc gcgggcggac acggtggtgt
    14581 ggctggaaga cggccgcgtc cgggctgtcg gcgcccacga cgagctgtgg cggactccgg
    14641 cttatcgcgc ggtcttcacc gagggtgcgc aatgagcgtc tgggggctct accgctcggc
    14701 gctggccggg cagtggcgcg gcgggctggt gctgctggcc tgctccgtac tggagagcgc
    14761 gcccgcgttc ttgtccggtc gcctggtcga actcgcggtt gacgaggggt ttgccgcgga
    14821 tcggccaggc accggactgc gttggctcgc ggtcttcggg ctggtcgccg tgatcggcgc
    14881 gttcggttcg cggctggtgt ggcatcagct cggcaaggtc gtcgagccgt tgcgcgacgc
    14941 gctggtgacc gccgtcgtgc gcggggtcct gcacgatccg gcgccgccac gcaatcagcc
    15001 ggacgccagc ggcgtcgccc gcatcaccca gcacgtcgag gtggtacgcg acgccacggc
    15061 cggactgctg gtgcaggcgc gcgggatgat cgtgacgacg gtggcggcgc tggccgggtt
    15121 gttcaccgtc gccggttcgc tcgcgttgat cgtcgcgatc ccggtggtgg tctcggtcct
    15181 cgtgttcgcc tgcctgctcc cgtcactggc gcggcgtcag cgcgcgctcg cgctggccga
    15241 cgagcggacc gccgaggtcg cgggcgcgtc gttgtccggt atgcgggaca tcgtcgcgtg
    15301 cggcgcggaa cccttggccg cgctggagct ctacgacgcc atcgacacgc aggccaaggc
    15361 ggccgtgcgg gtggcgcggt ccggggcggc ccggacggtg gtgatcgcga ccggcggttt
    15421 cgtgccgctg ctcctggcgt tgctggtggc gccgggcatg gtccaggccg gagtgctcac
    15481 cgccggtgcc gcgctcggcg cgctggtcta cctggcgacg acgatgcagc cggcgttgcg
    15541 cgggctggcc gcgaccgcga gcaccgtggt gctgcggctg atcgtcgcgc tgcggcggct
    15601 cgccgaaacc gccgaggccg agccggaggc cgacggcacg gccgaacccg acgggaccgc
    15661 gatctacgtg cgcgacctga ccttcagctg gggcgcggcc gcgcaaccgg tggtgcgcgg
    15721 actcgacctg cacctgcggc ccggcgagcg gctcgcggtg gtggggccga gcgggatcgg
    15781 caagtcgacc ttggccgggc tcctgaccgg catgctcacc ccgcaggccg gccgggtgct
    15841 gctcggtggg gtcccggtcc gggaggtccc ggcggcgctg cggcaccgga tggtcgcgct
    15901 gatcccgcag gaggcgtacg tcttcgcggg gaccgtgcgg gacaacgtcg gtctgttcgc
    15961 gcagaccgcg atggacggcg aactgctggc ggcggtgcgg gccgtcggcg cggaaccgct
    16021 ggtcacgcgg ctgggcgggc tcgacggcga gatcgggcac ggcacgctgt ccgccggtga
    16081 ggcgcagttg atcgcgctcg cccgggtgta cgcgagcgac gcgaccgtcg tcatcctcga
    16141 cgaggcgacg tcgcacctcg acccgcccgc cgaagcccgc gcggaacggg cgttcgccga
    16201 gcggggcggg gtgctggtgg tgatcgcgca ccggctgacg tcggcgctgc gcgcggaccg
    16261 ggtcctggtg atggacggca aggaaaccgc cctcggcacc cacctcgaac tcatggaccg
    16321 gtccacgcgc tacgcccagc tcatgcacgc gtggtcgccg cggttacccc agcccagtgc
    16381 gcagttcttc cagcgcgctc ctgagtagac cctcgacggg gaccggccgc cgggattcac
    16441 gatcgacgaa gacgtgcacg aagtgacctt ccgcgatcac cgtctccttc gaatacatcc
    16501 cgacctcgta gcggacgctg gaccggccga gatggcccac ccgcaggccg acttcgagtt
    16561 ctcccgggaa cgacaccgaa gcgtggtact tgcattggga ttccacgcac aacccgatga
    16621 cctcaccggt ctcgatgtcg agtcggccgc gttcgatcag ccaggtgttg atcacggtgt
    16681 ccatcaccga atagtggacg acgttgttga cgtgtccgta gacgtcgttg tccttccacc
    16741 gcaacggaac cgtctgccag tgcggatact cggcgttcac cacagcgtca ccgattcccg
    16801 caggatgacg gcgaggtcgg cttcggacgc ctcgcgcggc gccgtcgcca gcagccgttg
    16861 ttgtttcacc gtgccggaaa ccagagagtc cacatcggac tcggtgtagc cgacggcgcc
    16921 gatcccgttg gggatcccga tctcccgcat gatctggccg agtaccgcgg gcaggtgatc
    16981 ccgcagatcg cccggccatt cgtaatccgg cgcgagcagc cgcgccaccc ggatgtgccg
    17041 ttcgggcgcg gcgtcgaagg tgaaccggaa cgccgcgggc gcggtcagcg agacggccat
    17101 cccgtgcggc accatcgctt cgtcgcccgg atacccggac ggatggaagt cccgtacctg
    17161 cccggcgatc ggatacgcgt tggcgtgcgg gatgtgcacc ccggcgttgc cgaaaccgag
    17221 cccggcgaac gtcgccgcga gcgccatcgc ctcgcgcgcc ttcatgtcgg aaccgtcgcg
    17281 cacggccgcg ggcaacgccc acgacagcaa ccgcagcgac tgctcggcga acatgtcggc
    17341 cagcggattc gagccacagt aaggaacccg gtcctccggc cgcttccggt cgaactcggt
    17401 gtacggcttg gccgtgtagc tttccgcggc gtggcaaagg atgtccatcc cgctcgcggc
    17461 ggtcacctcg ggcggctgcg agaccgtgag cctcgggtcg accaccgcga ggctcggccg
    17521 catccggaga tggctgatgc cgctcttcac ccgcagcgac aacacgtcca gcacgcacac
    17581 cgtggtgctc tccgagcccg tcccggtggt ggtcggcacc gcgaccagcg gtttcagcgg
    17641 cgcgctcggg gcgcggccgc cgccgaccgg cgcgttgacg tagtccatca ggtcgccgtc
    17701 gttgctggtc aacaggttca ccgccttggc ggtgtcgatg gccgacccgc caccgacggc
    17761 gacgaaggcg tcccactcgc cctgtccccg cgcgaagtcg acggccttcc gcatgctgac
    17821 gtcggtcggc tcgacatgca cgccgtcgaa gacgacggct tcgatgccat aggtctcgat
    17881 gccttcggcg atccgttgtg gccagcccgt cgcggcgaca cccgcgtcgg tcaggacgag
    17941 cacccggcga gcgccgtact gggtgaggtc gtagccgatc tcatcgctcg acccggtgcc
    18001 gtacttcaag gcaggcgccc cgtaagtgaa aacagtttca cgtccggcgg tggctgaggt
    18061 cacgttttcg tgctcccttg ctcgaacacg ttccgaatat cggacattcc gccgctccgg
    18121 ggttgccgga atcggaagat cgcttgacgg caccgatcac cgcccgccta agctcttctc
    18181 attagatacc aaccgggagc gtccgtcgcc cagacggccg tgcggatcct gaccgaggcg
    18241 cagatccacc gcgtgtacgc ggtggtgggt gagtccttcc tggatctgct cgacgcgctg
    18301 caacgcgagc gctcgatcac cttcgtctcg gcgaggcacg actccggcgc cgccttcatg
    18361 gcggaggccg aaggcaagct caccgagcat cccgcggtcc tgctcgccgg ccgcggcccg
    18421 aacgcggcga acctcgcgat cggcgtctcc acggcgtacc aggacgagag cccgatggtc
    18481 gtcctcctgg agaacccgcc gcaggatccc ggcccgacga gcgagctgcc caccgcggac
    18541 ctgaccgcga tgttcgagcc gatctcgaag tggaccggcc gcgcggaatc ccccgacgag
    18601 gtccccggcc tgctggtcga ggcgctgacc cgctgccgtg aggggcggcc gggccccacc
    18661 gtcgtcgccg tccccgccga tttctggggt gtcccgttcg actcggcgaa accggtcgcc
    18721 tccgtgcggc cgccggccac cggcgcgctc ggccggaccg ccgaggcggt cgcgcagctg
    18781 gtcgacgagg cccgctaccc ggtggtgatc gtcggcggcc gggcccgcgc ggcgcgcgac
    18841 gagctgatcg ccgtcgccga cgagctcgcg ctgccggtgt acaacgcgtt ccgccgtcag
    18901 gacgcctttc ccgagaacca cgcgcgctac gccggccatc tcggcatcgg catccccgct
    18961 cggcagctcg acgcgctgga gcgcgcggac ctcgtgctcg cgctgggcac gcagctcgac
    19021 gaggtcacca cccagtcctt ccgttacccg acgccgtcgc agacgctggt gctggtcggc
    19081 accgggatcg agcccgcccg ccgcggcggc ctgaccttcc gggtcgactc cgaggtcgag
    19141 cccttcctgc gtgaactgcg caatgtcgcc tcgcctcggc aacggcgcgc gtcggccgcg
    19201 aacgcggcgg tgcacacctt catgacgccg cccgacacca gcggcgccac ccgcgtccac
    19261 cccgccgacg tcatccgcgc ggtgcgcaag ctcgcgcccg aagacgcgat cgttaccagc
    19321 gacgcgggca acttcgccca gttcatgcac cgctactggt gtttcaccgc gccgcgcagc
    19381 cagctcgggc cgagcaacgc ggccatgggc tacgcggtcc ccgcggcggt cgcggcgaaa
    19441 ctcgccgaac cacgccgcac ggtgatcgcg atggcgggcg acggcggcgc gctgatgacc
    19501 gggcaggaga tcgagaccgc cgtccgctac cgggtaccgg tgaccgttct ggtgttccag
    19561 aacggactgc acggcccgct cgccgtgcac caggcgcgca aacacgggcg gctgtcgggg
    19621 gtcaccgtcc ccgtcaccga cttcgcgtcg tgggcgcgcg ggctcggcgc cgccgggtac
    19681 accgtggacg atcgggaaga gctggagccg atcatcgcga gcgcgctggt gcggcaacgc
    19741 ccttgtgtga tcgacatccg gacggatccg gacgtggtga cgccggacat ccggttgacg
    19801 agcctgctgg gcgcgtcgag gcagcaacag ggcggccagt aggggccgcc acgccgatta
    19861 ccgggcggta ctttttctca ggggatacac agaaaccctt gtggtgccgc cttcacctgc
    19921 cccaaagggt gggaacgagg tgacgactcg gccgactttc ggtcgcggac accggatttt
    19981 gtcggtcggc cgtggcacaa tcgcggcaac accgagagtc cgatatggac cgggcaatgg
    20041 ccggtggggt tgttggcacg cagtacgtac ctagagcgtt gtgttgacac tgggagaaaa
    20101 catggctgac gaagcgaagc cacaggacaa gtccgtttcc ggcgtggtgc cggtgctgtt
    20161 cagcgcggac gcggagaccc acgacatcgc cgtcgtggcc acgaaccggg aggcgttgcg
    20221 ccgctcgccg ttcggcaacg aggcgccgct gcgcgcggcc agcggggaat agcccggccg
    20281 gtcgcccctc ctgtcggagg ggtacagtcg gcgaaggtgc agtgcggctg cgcacacccg
    20341 agtgatggcg cttgtcggcc tgcgtgaggt gtgctttact gcaccaggtc tcgatttttg
    20401 tgttcgtgtt ggttcacgct cgcagaactc agcgggcgta gtgtctcctc gtgtttccgg
    20461 ggaagcaaac cgtctggtca tgacccgggc tgccgacgtg gcttcctgtt tgtttgtgtt
    20521 gcatatggag attttatgac tcagggcact gtgaagtggt tcaactccga gaaggggttc
    20581 ggcttcatca ctcccgacaa cggcggcggc gacgtcttcg tgcactacag cgagatcaag
    20641 ggcaacggct tccgtaccct cgaggagaac gcccgcgtgg agttcgagat cgggcagggc
    20701 gcgaagggtc cgcaggccac ctcggtcacc gtgatctgat ccaggttttc caagcagggc
    20761 cgccatcccc tcggggaggc ggccctgctg cttttccggg accgttcttc acgcggggga
    20821 gacgagtccc gcctcgtacg cgagcacgat cgcctgagcg cggtcccgca ccccgagttt
    20881 cgccagtatc cggcccacat acgtcttcac ggtctgcgcc gacagcacca gatccgcggc
    20941 gatctccgga ttggaccgtc ctttcgcgat cagccgcagc acttcccgct cgcgttcggt
    21001 gagcacgtcg aaccgcgccg gggacggccg cggaaccgga gcggtggcca cgaagttcgc
    21061 gatgagccgc ttcgtgaccg cgggggagag cagcgcttcg ccggcggcga ccacttcgat
    21121 ggcgttgatc agctcggcgg acggcgcgtc cttcaacagg aatccgctcg cgcccgcccg
    21181 cagtgcctcg tagacgtagt cgtccagatg gaacgtcgtc aggacgatca ccttcggctt
    21241 cgcatcgtcg ccttcgagca accgcctcgt cgcttcgatg ccgtccatga ccggcatccg
    21301 gatgtccatc aggacgacgt ccggtcgcgt cgccaaggcg gaaatacccg cgagcgcctc
    21361 gattccgtcg ccggcttggc ccaccacgtc cagccccggc tgcgcgttca gcaggctggc
    21421 gaaactttcc cgcacgaggg cctggtcgtc gacgatgaag acggtcgtca cgcgtcactc
    21481 accctcggga gatccagttc gacggccacg cggaaaccgc cgtccggccg cggcccggcc
    21541 tcgtaggtgc cgccgatcag cgtaacgcgt tcggcgatcc cggcaaggcc ggtgccgtcg
    21601 cccgccgttg gtgccgcggg cctcgacggc gccccgtttt cgacgaggat cgtgagcgcg
    21661 tccggttctc gccgcaccac gacgtccact cccgcccccg gactgtgccg ggccgcgttg
    21721 ctcagcgcct cctgcaggat ccggtacgcg gccagttcga ccaaggcggg aatgccgtcc
    21781 ccatcgtcga tctccgcccg gatctcgatc ccggacgccc ggcagccgtc gatcagcgac
    21841 ggcacctccg cgagcccggg ctgcggctcg tgttccggtt cggcgtcggt gtcgcgcagc
    21901 accccgacca gccgcctggc ttcgtcgagc gcttccctgg ccgcgacccc gatggcgtgg
    21961 aactcctcgg ccgcggcctc ggacacgtcc gggacgcgat agcgcgcgct gtcggtccgc
    22021 agcgcgatca gcgagagatg atggccgatg atgtcgtgca actccctggc gatcagcgcg
    22081 cgttcctgca aggtggcccg tttcgtccgc tcctcgaccg tcgtgcgctc ggccgcgtcg
    22141 gcctgctcca gcgcccggcg gcgttgctgc atcccgtagc ccgccacgat ggtcacggcc
    22201 accacgacca acgaccacac cagggtcttc gtacccgccc gaggtatcca ggcgatgccg
    22261 accgcgacgg cgagtgccac cgcgatgatc gaaatcccta tgccctgccc gggcttcgtg
    22321 cgggcgagcg tcatcgcgag caccggcaga tagggcagga cctgtacctg caacggccat
    22381 tccgacagcg tggggccgaa cagcgcgtag tcggcgggga agaggatcgc gatgatcgcg
    22441 ctgatcattc ccgccgcggc cacccgcacg gcggtcagcg ggaagcggac gacgagcaac
    22501 ggcggcgtga tctgcaggat cagcaggaag aagatcagcg gcac
//
