LOCUS       NZ_LIWC01000002        22148 bp    DNA     linear   CON 28-MAR-2024
DEFINITION  Amycolatopsis sp. CB00013 scaffold2, whole genome shotgun sequence.
ACCESSION   NZ_LIWC01000002
VERSION     NZ_LIWC01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Amycolatopsis sp. CB00013
  ORGANISM  Amycolatopsis sp. CB00013
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 1966077)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1966077)
  AUTHORS   Yan,X., Ge,H., Hindra,F., Yang,D., Huang,T., Crnovcic,I. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-AUG-2015) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2014
            Assembly Method                   :: CLC Genomics Workbench v. 7.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905755.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:05:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,488
            CDSs (total)                      :: 8,430
            Genes (coding)                    :: 8,383
            CDSs (with protein)               :: 8,383
            Genes (RNA)                       :: 58
            rRNAs                             :: 1, 3, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (5S, 23S)
            partial rRNAs                     :: 3 (16S)
            tRNAs                             :: 50
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 47
            CDSs (without protein)            :: 47
            Pseudo Genes (ambiguous residues) :: 0 of 47
            Pseudo Genes (frameshifted)       :: 17 of 47
            Pseudo Genes (incomplete)         :: 38 of 47
            Pseudo Genes (internal stop)      :: 1 of 47
            Pseudo Genes (multiple problems)  :: 9 of 47
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:01:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 633868
            Orig. end                         :: 656016
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LIWC01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22148
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22148
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22148
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12148](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12148)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            798..1670
                     /locus_tag="AMK34_RS12995"
                     /old_locus_tag="AMK34_12885"
     CDS             798..1670
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016337671.1"
                     /locus_tag="AMK34_RS12995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_12885"
                     /product="nuclease"
                     /protein_id="WP_073845433.1"
                     /transl_table=11
                     /translation="MPMTLIKGTFQLVGASPDGDSVRFYPEDPQATKKAGLKVRLNSRG
                     GMQLRLDAIDALETHYQARGTGGIWHQPAEFADAAAANLLKCLGFKTVERDERGRVTSS
                     TPIKVAGHILTRFADKYGRAVAFAFPGQRPGRSADLSKVHLDVKTLKNSANYRQVADGL
                     VYPTFYSLLYPDLRDALAEAAVKARQNGLGLWPQDVTNSGFKLASRRQLADELVILPKL
                     FRRLVDYLALDESGGVSLTGFSDFLDSRNDRLFTVPDGHATEFETLVSVKRQTVSLTIE
                     PERIVFIEA"
     misc_feature    804..817
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.57"
                     /tool="antismash"
     gene            1747..2187
                     /locus_tag="AMK34_RS13000"
                     /old_locus_tag="AMK34_12890"
     CDS             1747..2187
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016337672.1"
                     /locus_tag="AMK34_RS13000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_12890"
                     /product="sigma factor-like helix-turn-helix DNA-binding
                     protein"
                     /protein_id="WP_228694790.1"
                     /transl_table=11
                     /translation="MEGHGSRRPEEADGRMEPTSKLVDAVRVLVVRYCRARIGRRSGTY
                     DIADAVAKDSCREIVAGTAGARALLAFAYDVTHGLVDDFHRTAAELPNPLSGLPGQQRE
                     IMVLRSLVGLSADDTALALGCSVQAVRLGQHRALTALRPAPA"
     gene            complement(2244..3518)
                     /locus_tag="AMK34_RS13005"
                     /old_locus_tag="AMK34_12895"
     CDS             complement(2244..3518)
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016337673.1"
                     /locus_tag="AMK34_RS13005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_12895"
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_073845435.1"
                     /transl_table=11
                     /translation="MVGVTATTDSRSAIDAVWRIESARLIAGLARMTRDVGLAEELAQD
                     ALVAALEQWPESGVPRNPGAWLMTTAKRRAVDTFRRNERYEKKLGEIGREQEYEEEPDF
                     TAGLDDHIEDDLLRLVFTACHPVLSTEARVALTLKMIGGLQTHEIARAFLAKETAIAQR
                     IVRAKKTLGDAKVPFEVPEGSDRVARLSSVLEVIYLIFNEGYSATAGEDWMRPALCEEA
                     LRLGRILAGLMPKEPEVHGLVALMEIQASRSAARVGPNGEPVLLMDQDRTKWNRILIGR
                     GLSALELSESLTGGAFGVYAAQAAIAACHARARTGEETDWARIAVLYEGLGKLNPSPVI
                     ELNRAVALSMAVGPEAGLEIVDKLTSEPALKAYHLLPSVRGDFLSKLGRLDEARAEFER
                     AAEMTGNDRERTLLLNRAAECTPRV"
     gene            complement(3549..3965)
                     /locus_tag="AMK34_RS13010"
                     /old_locus_tag="AMK34_12900"
     CDS             complement(3549..3965)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020421634.1"
                     /locus_tag="AMK34_RS13010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_12900"
                     /product="YciI family protein"
                     /protein_id="WP_038520666.1"
                     /transl_table=11
                     /translation="MRFMVIVKSDEKTDVAGAQPSAEELQEMGKFNEELVKAGVMLAGE
                     GLLPSSEGFRLQYSGTTEARVVDGPFAESKELIAGFWILQVKDRAEVIEWMKRAPFREG
                     EIEIRRIAELDDFDNATPEIVEHEKKLREQAEAK"
     gene            4099..5106
                     /locus_tag="AMK34_RS13015"
                     /old_locus_tag="AMK34_12905"
     CDS             4099..5106
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016337675.1"
                     /locus_tag="AMK34_RS13015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_12905"
                     /product="small ribosomal subunit Rsm22 family protein"
                     /protein_id="WP_073845437.1"
                     /transl_table=11
                     /translation="MRESSIVSALPETLRSALDEELGKYPQNRLTQSVERLSTRYRENA
                     PASAPILSSEADIAAYAGYRMPATYAAVHAVLAEAALRAPGFAPRTQIDIGGGTGAAIW
                     AAADVWPTLEESTVVEQVPGAIALGRRLAENAGDKAVRGATWRRGLIDPAAPAPEADLV
                     TLSYVLGELPEARRADTVRWLSAKASMLVLIEPGTPAGYERIVAARDQLVELGLSLVAP
                     CPHEGACPIPRGKDWCHFSARLPRTGLHRQLKSGTLGFEDEKFSYVVASRTAPERADAR
                     ILRHPAKRKGMVSLSLCAESGLTEKIVTKRHGPAYRAARDAEWGDAWPDHSTVD"
     gene            complement(5088..5999)
                     /locus_tag="AMK34_RS13020"
                     /old_locus_tag="AMK34_12910"
     CDS             complement(5088..5999)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005165203.1"
                     /locus_tag="AMK34_RS13020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_12910"
                     /product="LysR substrate-binding domain-containing protein"
                     /protein_id="WP_073845439.1"
                     /transl_table=11
                     /translation="MFSLEQLVSFVAVAEELHYGRAAERLSMTQPPLSRRIQLLERELG
                     AELFDRTHRTVRLTPAGRVFLAEARKILRSSHEATLYVRRVKKGEVGVVTLGFTATAAY
                     SYLERVIAAANAEVPGVDLVLREMVTAAQVEELLAGGIDLGMIRPPVAGADIVTLPLWR
                     EPLLAALPSAHPLARRKKNPDVRDFDAEPFIMYSPSEGRYFHDLLVAVFRAARVSPEYT
                     QYPCQVHTVLALVKAELGVALVPAAASTLRFEGVVLRPVDGVEGRPVELDLMWRRGNDN
                     PALGALLTAIGNPPRRRQSTVE"
     gene            complement(6052..6765)
                     /locus_tag="AMK34_RS13025"
                     /old_locus_tag="AMK34_12915"
     CDS             complement(6052..6765)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016337677.1"
                     /locus_tag="AMK34_RS13025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_12915"
                     /product="GAF and ANTAR domain-containing protein"
                     /protein_id="WP_073845441.1"
                     /transl_table=11
                     /translation="MTDSATALRETFVQLADTLVDDFDLIEFLDLLAFRCVELLGVCTA
                     GLLLADPRGTLTMVAASDEQTRLLELFQLQNSEGPCLDCYQDGEPVRCVDLVRARGRWP
                     KFAREAENAGFRSVYALPMRLREDVIGALNLFGTRPALLDDEGLRLGQALADIATIGIV
                     HHRLLQRQEIITAQLQTALNSRVIIEQAKGVLAERLRVSISDAFGVLRAYARSNNRKIL
                     AVATGIIDRTVEIRR"
     gene            complement(6798..7445)
                     /locus_tag="AMK34_RS13030"
                     /old_locus_tag="AMK34_12920"
     CDS             complement(6798..7445)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033486.1"
                     /locus_tag="AMK34_RS13030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_12920"
                     /product="ANTAR domain-containing protein"
                     /protein_id="WP_241832758.1"
                     /transl_table=11
                     /translation="MTVEHACIVCGEVLEAAGVGLTLAAKGGPAEPVFATDERSRELED
                     LQFTLGEGPALEVMDGGTLVVVTDMTDSEASLRWPMFAPEAIDRGVKSIIAVPIQAGVI
                     KLGVVDCYRELAGLPSVHGQAEALVCAEAAITLAVADADIGRPGLAELIDLEFTQHRAQ
                     VHQAAGMVSVQLDIGLRDALARLRAHAFANGRKLSEVAEDVVTRRFAFRPGS"
     misc_feature    7433..7445
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.62"
                     /tool="antismash"
     gene            complement(7884..8504)
                     /locus_tag="AMK34_RS13035"
                     /old_locus_tag="AMK34_12925"
     CDS             complement(7884..8504)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016337679.1"
                     /locus_tag="AMK34_RS13035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_12925"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_073845445.1"
                     /transl_table=11
                     /translation="MSDEFPMRRTGGGETWISAASWDGLAKAAADGEPHGMDDLMAAVA
                     TWARQYTETRLGGHELTYLEPADVAQEICLAVLVAVPGYGVRGGSFLFLLRAIAANKVA
                     DVFRKAARSKQVLTGELPERPAGPADEPEQRALRTDLGVRLGRLMRMLPVSHREVLGMR
                     VIGELTSNETAAALGTTSSRVRVTKHRAISRLRACAQRQDALS"
     misc_feature    complement(8651..8666)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 21.01"
                     /tool="antismash"
     gene            8809..9996
                     /locus_tag="AMK34_RS13040"
                     /old_locus_tag="AMK34_12930"
     CDS             8809..9996
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005165211.1"
                     /locus_tag="AMK34_RS13040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_12930"
                     /product="beta-1,3-glucanase family protein"
                     /protein_id="WP_073845447.1"
                     /transl_table=11
                     /translation="MRIRKKVRRVLTALAVALPLVTGVSALSASTAAAAGPDPLPLTVT
                     NNSNRSDAVHLYVLGTNLDTGKLGYVNAAGAFTAWPPGANPPSPAPDVSIAGPGNGGST
                     TLRIPRMLSGRVYMSFGQKIKFFLTPDGLVQPAPWADGDPNRDILFDWSEFTYDNGGLF
                     INSSQVDMFSVPHAVGLTNGAGANKEAGRLKPGGRENIFNAVQGQSGFSNLVYNRLRVL
                     APGKGLDTGKFSGNYLDGYVTSAWNTYKSTPLAVVPFEAEPGKKFTGRTGGDDVLRFTD
                     TSGAEVASFSKPSTRDVFNCDGRLHAPNDQVVGPIARTLCAALHRSTLGSLHTQPTYDA
                     GQFYKQSVTDHYSRIVHEQMVDGKAYGFAFDDVGHFESLVHDGDPRTARITLTAF"
     gene            complement(10001..12148)
                     /locus_tag="AMK34_RS13045"
                     /old_locus_tag="AMK34_12935"
     CDS             complement(10001..12148)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016337681.1"
                     /locus_tag="AMK34_RS13045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_12935"
                     /product="Geosmin synthase"
                     /protein_id="WP_073845449.1"
                     /sec_met_domain="T1TS (E-value: 1.8e-77, bitscore: 258.4,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQAFTLPEFYLPHPARMNPHLEAARAHSMAWAGEMGMLDSPSPSG
                     DVVWTEQALAKMDYALLCAHTHPDCDGPSLDLVTDWYVWVFFFDDDFLAQFKYTRDTEG
                     AKAYLDRLELFMTGPGETSPEPANPAEAGLENLWARTIPSMSEAWRRRFVTSTHNLMVE
                     SLWELDNIDRGRIANPIEYVQMRRRVGGAPWSANLIEFAVGAEVPDGIAATRPMEVLRD
                     TFADAVHLRNDLFSYQREVREEGENSNAVLVFEKFLDCPTQEAAELTNDLLTSRLQQFE
                     NTALVEVPALLAERDVSLPEQIAVGLYVKGLQDWQSGGHEWHTRSSRYMNEGADSGTDS
                     LGLGRRIRQQAPPPFAKTGHLPLPEFRMPYPVRTSPHLAAAREYAPGWAREMGMLDGGV
                     WDERRFRGLDLAYCAAMIDPDADLDGLKLSTDWLTWGTFGDDYFPLVFGAKRDAVAAKL
                     CSDRLSLFMPLEGEPVPKPSNPIEVGLADLWGRTAGPLSPRTRAGFRQAVESMTASWVW
                     EVGNQAQNRVPDPVDYVEMRRRTFGSDLTKSLALLELGDVVPAELFRNRVLFELDTAAQ
                     DYAAFSNDLFSYQKEIEYEGETHNLVYVAERFLDVDRNEARDIAARLGNARMTQFEQLA
                     DEDLPRMCDDLGLGDDVRAAVTGYADHLKDWMAGILEWHRKCVRYTPEELARVHAPEPP
                     VFSLVPSGIGMSAWRIGSGAR"
     gene            complement(12254..13033)
                     /locus_tag="AMK34_RS13050"
                     /old_locus_tag="AMK34_12940"
     CDS             complement(12254..13033)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016337682.1"
                     /locus_tag="AMK34_RS13050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_12940"
                     /product="DUF3800 domain-containing protein"
                     /protein_id="WP_073845451.1"
                     /transl_table=11
                     /translation="MRSVPLEIACDESGSEGEKLIGGRTGVFAHAGVRLSLEETAACLV
                     ELRRRIRSPALEYKANHLLRTKHRRVLEWFLGPRGPVHGRAQVYLVDKKRLLANELRAL
                     AGPEIRPDDELLAAFNDVLRTRNRRDPAAGSFFAMAGDTAELRAKVGRTRDAKSLDPLV
                     PAILRAIEYWSAGGEPVFLVHDEQPSLKGDRLARIESSPGLAGVKFVDSRTDPRVQVAD
                     FLVGVARRIAEDALNGNGDEILTGLLVPYVDPESLWD"
     gene            complement(13066..13857)
                     /locus_tag="AMK34_RS13055"
                     /old_locus_tag="AMK34_12945"
     CDS             complement(13066..13857)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016337683.1"
                     /locus_tag="AMK34_RS13055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_12945"
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_038520693.1"
                     /transl_table=11
                     /translation="MDEVFKALADPSRRRLLDDLNARNGQTLRELCAGLDMARQSVSKH
                     LAVLEAANLVTTVWRGREKLHYVNAEPINAIAERWIDRYHQGRVDALADLKKALEQEPM
                     STDEFVYTSYIRTTPERLWQALTDPVFTKRYWGCEFTSDWKAGSTMAWEQLGVKLEDPE
                     QVVLESDPYRRLSYTWHTFTPEFAKSVGLDDDVSAKLQAESRSKVTFDLEPVGDMVKLT
                     VVHDGFDQGSTALEMVKGGWPSILSSLKSLLETGEPLPEPA"
     gene            14152..14838
                     /locus_tag="AMK34_RS13060"
                     /old_locus_tag="AMK34_12950"
     CDS             14152..14838
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK34_RS13060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AMK34_12950"
                     /product="hypothetical protein"
                     /protein_id="WP_143202440.1"
                     /transl_table=11
                     /translation="MKADSRTKHARRLLLCLHVLASVAWCTMQLAQLALLLRGWSSDGP
                     ARLATFELAEFLENTVLDPAAIVSAYTGMMLSALTSWGFFKHRWVMVKFVITVALLVIA
                     STVVSRLLPSVVEALRAGAEEPRIPILVGTCGMACATAFLLWVSVVKPWGKTARHAAEL
                     KAKKARGRKEPEPSLPVYVAVLLIPAIEFGFALDYPILTFGTVIGYSIFKSVSRRSHKA
                     EPAATA"
     gene            complement(14840..16429)
                     /locus_tag="AMK34_RS13065"
                     /old_locus_tag="AMK34_12955"
     CDS             complement(14840..16429)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024949.4"
                     /locus_tag="AMK34_RS13065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_12955"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_073845455.1"
                     /transl_table=11
                     /translation="MAEQRDDLAGLLSALKQRSGLSYAELARRTYVSSSTLHRYCTGRS
                     EPPDYQLVAAIAKECGATDDELNELVRRWRRRGDDAPEPEPAPVPIAVSEPQPRRRGRP
                     IAAVLVVLMVLVVTASAPSGTGADASVEALSAAPWVREPVEVSPELFGVTMNSDTGTMP
                     AFRVGGVRFWDSHTRWANLQPARDRFDWATLDRLVDGAEKAGLPSLFVLGGTPGWAAPN
                     SPKGAYTDGSRTGSPENLADWDRFVEALVSRYRGRLDAYELWVQASNPKYYSGSVETLV
                     QMTGRAARIVRSFDPDATLVCPSMGQLWQPAGRETLKRFAELGGYDHCDVAGVKLHQRH
                     PADPPETLVNLLREIDDTMHAAGVHPPLWNTGTTYDIPLQERLSPKRSVDHAVRFYLAG
                     LYGREFGMRRMYFYNWGSSRLPLVLQVEGTPPTRAALAVETLQRWLAGTRLRGCAQGLP
                     AGLPANVWQCEFVDGADRLLTIRWTHSGSAFTTAGPGAESRTGLDGTVTPLRPGDPVQV
                     TETPALITHSGG"
     gene            16594..16995
                     /locus_tag="AMK34_RS13070"
                     /old_locus_tag="AMK34_12960"
     CDS             16594..16995
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK34_RS13070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AMK34_12960"
                     /product="hypothetical protein"
                     /protein_id="WP_073845457.1"
                     /transl_table=11
                     /translation="MNKRRAVLAAAAAPILAMTAAATPAQADAPITIQGNCTYPGLGQE
                     LCGRVINHKDSEKWLVVADGWNCGGSGTACGDKVRLYPGDLSTDSYKDADGVYIPNGCT
                     GHLGLRELKGGKWTKISDSIGYYKVKVKC"
     gene            17107..17472
                     /locus_tag="AMK34_RS13075"
                     /old_locus_tag="AMK34_12965"
     CDS             17107..17472
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016337684.1"
                     /locus_tag="AMK34_RS13075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_12965"
                     /product="hypothetical protein"
                     /protein_id="WP_073845459.1"
                     /transl_table=11
                     /translation="MPTPLRVAIAVQTLAVFLTPISAGLLLTVPSGHTLHSATAYTLFS
                     VSMLHVLVAVLVWRPGGGSAKPILPAAVFLGLTLVQVFLGIAHVTAVHVPLGVLLFGFS
                     LVQLSRIRPLPREAAAP"
     misc_feature    17518..17529
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     misc_feature    17560..17574
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.6"
                     /tool="antismash"
     misc_feature    17578..17593
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 23.65"
                     /tool="antismash"
     misc_feature    complement(17578..17594)
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 24.31"
                     /tool="antismash"
     gene            17597..18490
                     /locus_tag="AMK34_RS13080"
                     /old_locus_tag="AMK34_12970"
     CDS             17597..18490
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070967 - coenzyme F420 binding [Evidence
                     IEA]"
                     /GO_process="GO:0008150 - biological_process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013223310.1"
                     /locus_tag="AMK34_RS13080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_12970"
                     /product="TIGR03619 family F420-dependent LLM class
                     oxidoreductase"
                     /protein_id="WP_073845461.1"
                     /transl_table=11
                     /translation="MRLGFSLPVFGKAAATPGGIARYARTAEQAGAASLWVGDRLLSPV
                     NPEVAYPGYDTMPEEFWTAQDPFTALAVAAAVTETAILGSSTINATQYQPANFARLLTS
                     IDVASNGRLLPGLGIGWSPDEYAAVGVPMAERGKRLDDLLDLLDTWWTKDTVSHNGIGY
                     TIPETHVHLKPVRKPPVHLAGFGERALRRVAERADGWLPVWTVPETIPADMLTSTLAKI
                     RADAEQAGRDPRTLGVALRVNAAPDTKPELIAESVTKIVATLAPDHTFVDLTYLTSSVE
                     EHIDLTGRLLELTAMG"
     gene            18727..18858
                     /locus_tag="AMK34_RS43735"
     CDS             18727..18858
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK34_RS43735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_274534430.1"
                     /transl_table=11
                     /translation="MYEAMHTNEEIRDELASRMVLAALPTFLTTAFEKNAGDLISHH"
     gene            19217..19465
                     /locus_tag="AMK34_RS13090"
                     /old_locus_tag="AMK34_12980"
     CDS             19217..19465
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK34_RS13090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AMK34_12980"
                     /product="hypothetical protein"
                     /protein_id="WP_073845465.1"
                     /transl_table=11
                     /translation="MSPSSNSRDATSTGRRAQVAFAMQLNPDRFPVTVAVADALPAPPE
                     DAFEFGLRLIITGPGELRHPAGADDVTGRQRAADAAR"
     gene            complement(19428..20117)
                     /locus_tag="AMK34_RS13095"
                     /old_locus_tag="AMK34_12985"
     CDS             complement(19428..20117)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014906.4"
                     /locus_tag="AMK34_RS13095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_12985"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_198941674.1"
                     /transl_table=11
                     /translation="MSKPSLSTEAAAFARRSRGRPAVPLDRILAAALQLVDEEGAEALS
                     MRSLAQRLESGTATLYRHFGNRATLINHVIDRVFGEIELDSRTLAELRWDQACHAVAQA
                     MFDTLGRHRQIAPLLIEQTPTGPNAMVLRERCLAVLLDGGLPPSLAARAYATLARYVLG
                     FAIQLVGSGNGAEQERVSARFHDLSSVDFPATRRVADSLPVPLEDEFAFGLELIVNGLR
                     QLHAAAR"
     gene            20177..20971
                     /locus_tag="AMK34_RS13100"
                     /old_locus_tag="AMK34_12990"
     CDS             20177..20971
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (24-131). E-value:
                     5.5e-29. Score: 93.4. Matches aSDomain:
                     nrpspksdomains_AMK34_RS13100_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.4"
                     /locus_tag="AMK34_RS13100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_12990"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_073845467.1"
                     /sec_met_domain="PF00561 (E-value: 4.1e-23, bitscore: 79.2,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.6e-22, bitscore:
                     78.1, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSNHTRSVSVDGVRVHYERAGQGPAVVLLHGSGSSLEGFERVAE
                     LLSASHDVIRPDLPGFGRTGPRPDRDYRVRTYAGTIARFMTALGVPQFAVAGNSLGGNI
                     AWNLALDAPERVDALVLINATGYPEKTLPAGLRLARNPLLRPLVRRWLPRGATERGLRE
                     AVGANSAIVDDAMVDRVHALTSRPGNRSAFVDFANTDQPDRSGDLPKIAVPTLVLRSAS
                     VDGQHFARDIPGAHERVHTGGGHLLPEEDPDWVATAIREFLR"
     aSDomain        20249..20569
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMK34_RS13100_Abhydrolase_1.1"
                     /evalue="5.50E-29"
                     /label="AMK34_RS13100_Abhydrolase_1.1"
                     /locus_tag="AMK34_RS13100"
                     /protein_end="131"
                     /protein_start="24"
                     /score="93.4"
                     /tool="antismash"
                     /translation="PAVVLLHGSGSSLEGFERVAELLSASHDVIRPDLPGFGRTGPRPD
                     RDYRVRTYAGTIARFMTALGVPQFAVAGNSLGGNIAWNLALDAPERVDALVLINATGYP
                     EKT"
     gene            20968..21864
                     /locus_tag="AMK34_RS13105"
                     /old_locus_tag="AMK34_12995"
     CDS             20968..21864
                     /NRPS_PKS="Domain: Abhydrolase_1 (55-278). E-value: 1e-20.
                     Score: 66.3. Matches aSDomain:
                     nrpspksdomains_AMK34_RS13105_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.4"
                     /locus_tag="AMK34_RS13105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_12995"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_073845469.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 8e-15, bitscore:
                     52.9, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 1.5e-13, bitscore: 47.9,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYFVASDEDRRLDAATRRTLRGDFVALSDGVTHYELTGPEDGEL
                     AVLVGGITIPLSYWDGLAARLHARGLRTLACSAYGRGYSDRVRGRYDEALFVRQLAELT
                     AALGLTGPHHVVGTSMGALVAMAYANRDPATVATLTIVGPAGLGARPLPQRLLRNDLIA
                     GFIARRFGRNLLEDHLGHNVRDPGLSARLVAMVQDAYRYEGSLYAFFQTLQDFPLHERK
                     DLFRRTGELGLPVLLVWGDDDQVTPITHLGTVHELLRPRQTHVITECGHMAPYERPDDV
                     GDLLASFTVPHPERLEP"
     aSDomain        21133..21801
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMK34_RS13105_Abhydrolase_1.1"
                     /evalue="1.00E-20"
                     /label="AMK34_RS13105_Abhydrolase_1.1"
                     /locus_tag="AMK34_RS13105"
                     /protein_end="278"
                     /protein_start="55"
                     /score="66.3"
                     /tool="antismash"
                     /translation="LSYWDGLAARLHARGLRTLACSAYGRGYSDRVRGRYDEALFVRQL
                     AELTAALGLTGPHHVVGTSMGALVAMAYANRDPATVATLTIVGPAGLGARPLPQRLLRN
                     DLIAGFIARRFGRNLLEDHLGHNVRDPGLSARLVAMVQDAYRYEGSLYAFFQTLQDFPL
                     HERKDLFRRTGELGLPVLLVWGDDDQVTPITHLGTVHELLRPRQTHVITECGHMAPYER
                     P"
     CDS_motif       21295..21357
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMK34_RS13105_0001"
                     /evalue="2.50E-04"
                     /label="NRPS-te1"
                     /locus_tag="AMK34_RS13105"
                     /protein_end="130"
                     /protein_start="109"
                     /score="13.6"
                     /tool="antismash"
                     /translation="TGPHHVVGTSMGALVAMAYAN"
ORIGIN
        1 tcggcctcgc gctcgcgacc accggggtga tgttcccgtt gttctccgcc tacatcggct
       61 ggctgggcgt cttcctcacc ggctcggacg cgtcgacgaa cagtctcttc gggccgatgc
      121 aggtgatttc ggcgcagcaa ctgcacgtcg acccgatcct cgccggcgcc accaacacct
      181 ccggcggcgt gatgggcaag atgatctcgc cgcagaacct gtccatcggc gccaccgcga
      241 tcggtcagtc cgggaaagaa ggcgcgctgc tgcggcagac gttcctgtgg tccgtggtgc
      301 tgaccgccgt ggtcggggtg atctcgttgc tgcaggcgac ggtgctgcgg ttcatgatcc
      361 cgtcgtgaac gtgaatgccg gtcggcgacc gtgtcgcgaa agccactttc gggacatcac
      421 acgtcgcgaa agtggcttcc gcgacacgcg ccccggccag ggccaagggc acgacacaga
      481 ggcgtagtga aggcctcctt ccctaccgtc agggtaggga aggaggcctt caccagctgg
      541 gccgtcagcc gccccttttg ccttgccctc aagagtcacc gccccgtgcc cggcggggat
      601 ttcgcgtgac tggcgggacg acacgcgtga cgggacggac gacacgcgtg ttcagacgga
      661 cgactcaccg actttcggcg caggccgtca ttaccctttc gagaatgtcc acattggtca
      721 tccgatctta accggccatt gggctggatg gatgaacacc ggatccgttc accggaatgc
      781 gaactaccgt tgtcctcatg cccatgacgc tgatcaaagg tacgttccag cttgtcggag
      841 cctcaccgga cggcgattcg gtgcggttct atcccgaaga cccgcaggcg accaagaagg
      901 cgggcctgaa ggtccggctc aattcgcggg gcgggatgca gttgcggctc gacgcgatcg
      961 acgcgctcga aacgcattac caggccaggg gaaccggcgg gatatggcac cagcccgcgg
     1021 aattcgccga cgccgccgcg gcgaacctgc tgaagtgcct cggcttcaaa accgtcgaac
     1081 gcgacgaacg gggaagggtc acatcgtcga cgccgatcaa ggtagccggt cacatactga
     1141 cgcgattcgc cgacaaatac ggacgagccg tggcgttcgc ctttcccggg cagcggccgg
     1201 gacggtcggc ggacctttcc aaggtccacc tcgacgtcaa aacgctgaag aactccgcga
     1261 actaccggca ggtcgcggac ggtctcgtct atccgacgtt ctattcactg ctttatcccg
     1321 atctccgtga cgccttggcc gaagccgcgg tcaaagcccg ccagaacggg ctcgggctgt
     1381 ggccgcagga cgtcacgaac tccgggttca agctcgcgtc gcggcggcaa ctggccgacg
     1441 aactggtgat cctgccgaaa ctgttccgcc ggctcgtcga ctacctcgcg ctcgacgaaa
     1501 gcggcggagt ctcgctgacc ggcttctccg acttcctcga ttcccgcaac gatcgcctgt
     1561 tcaccgtccc ggacgggcac gcgacggaat tcgagacctt ggtgagcgtg aaacggcaga
     1621 ccgtgagcct cacgatcgag cccgagcgga tcgtcttcat cgaggcctga cccgctcgtg
     1681 tgggcaaaaa gaccgtacct ccctcccccg cggccgtgct catctgaaag gtgggagagg
     1741 gagccgatgg aaggacacgg ttcgcgacgg ccggaggagg ccgacgggcg gatggagccg
     1801 acttcgaaac tcgtcgacgc cgtccgcgtc ctggtcgtgc gttattgccg ggcgcggatc
     1861 ggtcgtcgtt cgggcaccta cgacatcgcc gacgcggtcg ccaaggacag ctgccgcgag
     1921 atcgtcgccg ggacggccgg tgcgcgcgcc ctgctcgcgt tcgcctacga cgtcacgcac
     1981 ggtctggtcg acgacttcca ccggaccgcc gccgaactgc cgaacccgct ttcggggctg
     2041 ccggggcagc agcgcgagat catggtgctg cggtcgctcg tcgggctttc cgccgacgac
     2101 accgcgctcg cgctcggctg ctccgtccag gcggtccggt tggggcagca ccgggcgctg
     2161 accgcgcttc gccccgcccc cgcctgacgc atttcgtcct ctgaatgcgg tggttcgcag
     2221 gtcgaaccac cgcattcaga ggactaaacg cgaggggtgc attcggccgc gcggttcagg
     2281 agcagggtgc gctcccgatc gttcccggtc atctccgccg cgcgctcgaa ctcggcgcgg
     2341 gcctcgtcga ggcggccgag cttcgacagg aagtcgccgc gcacgctcgg caggaggtgg
     2401 tacgccttga gcgcgggctc cgacgtcagc ttgtcgacga tctccagccc cgcctccgga
     2461 ccgacggcca tcgacagcgc caccgcgcgg ttcagttcga tcaccggcga cgggttcagc
     2521 ttcccgagcc cttcgtacag gacggcgatc cgcgcccagt cggtctcctc gcccgtccgc
     2581 gcccgcgcgt ggcaggcggc gatggcggcc tgcgccgcgt agacgccgaa agcgccgccc
     2641 gtgagcgact cggagagctc cagcgcggag aggccgcggc cgatcaggat ccggttccat
     2701 ttcgtgcggt cctggtccat cagcaacacg ggttcgccgt tcggcccgac gcgggcggcg
     2761 gaccgcgaag cctggatctc catcagcgcg acgagcccgt gcacctcggg ttccttcggc
     2821 atcagcccgg cgaggatccg cccgagccgc agcgcctcct cgcacagcgc gggccgcatc
     2881 cagtcctcgc ccgccgtcgc cgaatagccc tcgttgaaga tcaggtagat gacttcgagc
     2941 accgaggaga ggcgcgcgac cctgtccgac ccctcgggca cctcgaacgg caccttggcg
     3001 tcgccgagcg tcttcttcgc ccgcacgatc cgctgcgcga tggcggtctc cttggccagg
     3061 aacgcccgcg cgatctcgtg cgtctgcagc ccgccgatca tcttcagcgt cagcgccacc
     3121 ctggcctcgg tcgaaagcac cgggtggcag gcggtgaaca ccagccgcag cagatcgtcc
     3181 tcgatatggt cgtcgaggcc cgcggtgaag tcgggctcct cctcgtactc ctgctcgcgg
     3241 ccgatctcgc cgagcttctt ctcgtaccgc tcgttgcgcc ggaaggtgtc gaccgcccgg
     3301 cgtttggccg tggtcatgag ccaggcgccc ggattcctcg ggacgcccga ctcaggccac
     3361 tgttcgagcg cggcgaccag cgcgtcctgc gccagctcct ccgcgaggcc gacgtcgcgc
     3421 gtcatccgcg cgaggccggc gatgaggcgg gccgattcga tccgccacac cgcgtcgatc
     3481 gccgaacggg agtctgtcgt tgccgtcacg ccgaccaatc aacatcgtcg gcgcggcgac
     3541 cgcaaccatt acttcgcctc ggcctgctcc cgcagcttct tctcgtgctc gacgatctcc
     3601 ggggtcgcgt tgtcgaagtc gtccagctcg gcgatccggc ggatctcgat ctcgccctcg
     3661 cggaacggcg cgcgcttcat ccattcgatg acctcggccc ggtccttgac ctgcaggatc
     3721 cagaaacccg cgatgagttc cttgctctcg gcgaacggcc cgtcgacgac gcgcgcctcg
     3781 gtggtgccgg agtactggag gcggaaaccc tcggagctgg gcagcaggcc ttcacccgcg
     3841 agcatgacgc cggccttcac cagttcctcg ttgaacttcc ccatctcctg cagctcctcg
     3901 gcgctcggct gggcgccggc cacgtcggtc ttctcgtcgc tcttgacaat caccatgaac
     3961 cgcatcgaag tctccgttcc cggcggggct cgtccctgcc acatctacgc gtcgatcggg
     4021 caccccggga ttcgacacgg tccccgaact tttttccgcc gatattcgag cagccggaaa
     4081 accgcaggtc aaccacccat gcgagaatct tcgatcgtgt ccgcactccc cgaaaccctc
     4141 cgctccgccc tcgacgaaga gctgggcaag tacccgcaga acaggctgac gcagtccgtc
     4201 gagcggctca gcacgcgcta ccgcgagaac gcccccgcga gcgcgcccat cctctcgtcc
     4261 gaagcggaca tcgcggcgta cgcgggctac cggatgccgg ccacgtacgc ggccgtacac
     4321 gccgtcctcg ccgaagccgc ccttcgcgcc cctgggttcg ctccgcgcac gcagatcgac
     4381 atcggcggcg gaaccggcgc cgcgatctgg gcggcggccg acgtgtggcc gacgctggag
     4441 gagagcaccg tcgtcgagca ggtccccggc gcgatcgcgc tggggcggcg gctcgcggag
     4501 aacgccgggg acaaggccgt ccggggcgcg acctggcggc gcggcctgat cgacccggcg
     4561 gcgcccgcgc ccgaggccga tctggtgacc ctctcctatg tcctcggcga gctgcccgaa
     4621 gcgcgccggg ccgacaccgt ccgctggctc tcggcgaagg cctcgatgct ggtgctgatc
     4681 gaacccggca cccccgcggg ttacgagcgg atcgtcgcgg cgcgggatca gctcgtcgaa
     4741 ctcgggctct ccctggtcgc gccctgtccg cacgagggcg cgtgcccgat cccgcgcggc
     4801 aaggactggt gccatttctc cgcgcgcctc ccgcgcacgg gcctgcaccg tcagctcaag
     4861 tccggaacgc tcggcttcga ggacgagaag ttctcctacg tcgtcgcctc ccgcacggcg
     4921 ccggaacgcg ccgacgcccg catcctgcgg catccggcca aacgcaaggg catggtcagc
     4981 ctgtccctgt gcgccgagtc cggtctcacc gagaagatcg tcaccaaacg acacggcccg
     5041 gcctaccgcg cggcccgcga cgcggaatgg ggcgacgcct ggcccgatca ctccacagtg
     5101 gactgacggc gccgcggagg attgccgatg gcggtgagca gcgcgccgag tgccggattg
     5161 tcgttgccgc gccgccacat caggtcgagt tccaccggac ggccctcgac cccgtccacc
     5221 ggacggagca cgacaccttc gaagcgcagc gtgcttgccg cggccgggac cagcgcgacg
     5281 ccgagttccg ccttcaccag cgcgagcacc gtatgcacct gacaggggta ttgcgtgtac
     5341 tccggcgaca cccgggcggc gcggaacacc gcgacgagca gatcgtggaa gtaccggcct
     5401 tccgacggcg aatacatgat gaacggttcg gcgtcgaaat cgcggacgtc gggattcttc
     5461 ttgcgccgtg ccaaaggatg cgccgacggc agcgcggcca gcagcggttc ccgccacagc
     5521 ggcagggtca cgatgtcggc gcccgcgacc ggtggccgga tcatgccgag gtcgatcccg
     5581 cccgcgagca gctcctccac ctgcgccgcc gtcaccatct cccggagcac gagatcgacg
     5641 ccgggcacct cggcgttcgc cgcggcgatg acgcgttcga gatacgaata cgccgccgtg
     5701 gcggtgaaac cgagcgtcac gacgccgacc tcacccttct tcacgcggcg gacgtacaac
     5761 gtcgcctcgt gcgacgaacg caggatcttc cttgcctcgg cgaggaaaac ccgtccggcg
     5821 ggggtcagcc ggacggtgcg gtgcgtacga tcgaaaagct cggccccgag ttcccgctcc
     5881 agcagctgga tccgcctgct caacggcggc tgcgtcatcg agagccgctc cgccgcccgg
     5941 ccgtagtgca gttcctcggc caccgcgacg aaactcacca gctgctccag ggagaacacc
     6001 catccagtct aggaatcggc ctggggcgga caagcgccga accggtatcg ctcagcgccg
     6061 gatttccact gtgcgatcga tgatccccgt cgccacggcg aggatcttgc ggttgttgct
     6121 ccgcgcgtag gcgcgtagta cgccgaacgc gtcgctgatc gaaacgcgga gccgttcggc
     6181 caacacgcct ttcgcctgtt cgatgatgac ccggctgttc aacgccgtct gcagttgcgc
     6241 ggtgatgatc tcctgccgct gcagcaggcg gtgatgcacg atgccgatcg tggcgatgtc
     6301 cgcgagtgcc tgtcccagcc gcaatccctc gtcgtcgagc aaggcgggac gcgtgccgaa
     6361 caggttcagc gcgccgatca cgtcttcccg caaccgcatc ggcaacgcgt acacggaacg
     6421 gaatccggcg ttttccgcct cccgggcgaa cttcggccat cttccgcgcg cacgcaccag
     6481 atccacgcat cgcaccggct cgccgtcctg gtagcagtcc aggcagggcc cctcggagtt
     6541 ctgcagctgg aacaattcga gcaaccgggt ttgttcgtcg gaagcggcca ccatggtgag
     6601 cgtgccgcgc gggtcggcga gcaacaggcc cgcggtgcag acgccgagca gctcgacaca
     6661 tctgaacgcg agcagatcga ggaactcgat gaggtcgaag tcgtcgacaa gcgtgtccgc
     6721 cagctgcacg aaggtttctc gcaaggcggt cgccgagtcg gtcatctttt ccgttctctc
     6781 cttaggcact cgacccatca cgagccgggc cggaacgcga acctgcgcgt caccacgtcc
     6841 tcggccacct cgctcagctt gcggccgttg gcgaaggcgt gggcacgcaa gcgggcgagc
     6901 gcgtccctga gcccgatgtc gagctggacc gacaccatgc ccgcggcctg gtggacttga
     6961 gcacgatgct gggtgaattc gaggtcgatc agttcggcga ggccgggcct tccgatgtcg
     7021 gcatcggcga cggcgagggt gatcgcggct tcggcgcaga cgagtgcctc cgcttggccg
     7081 tgcaccgaag ggagcccggc gagttcgcga tagcagtcga cgacgcccag tttgatcacc
     7141 ccggcctgaa tgggcaccgc gatgatcgat ttgacgcctc tgtcgatcgc ctcgggagcg
     7201 aacatcggcc accggagcga cgcctccgaa tcggtcatat cggtgacgac gacgagcgtc
     7261 ccgccgtcca tcacctccag cgccggtcct tctcccaggg tgaactgcag gtcttccaat
     7321 tccctgctgc gttcgtcggt ggcgaagacc ggctcggcgg gacctccttt cgcggcgagg
     7381 gtgaggccga cgcccgcggc ctcgagaacc tctccgcaga cgatgcacgc gtgttccact
     7441 gtcaccgcgg atccggattc cgaagcgagg ttacgcaact tcgcccatac cagtgcggtg
     7501 tgatcgggcc ttgcaggcct catgtctgcc tctcggcgtt gtccggtgcc ggacgggatc
     7561 gccgaggtca ggggcgaaca gtgcgaacct gccgttcgcg ccgcgaccat actcccacgt
     7621 ttccgctctt tgccgtgccc acaacgactt cttcggcact aatgcagtag cccgaagggc
     7681 tgaatggcgg gtgcgggtgg ccgtcaatgg tccgttcagc cggttccggc tccccggacc
     7741 gcgcctaggg tgggaaacga gaccgcttgt cctggccctc ggcaacggtg ctcgccggcg
     7801 agctctggag gggccatgtg cgttcgcatt ctcgaaaccc gcgccaaacg ggagaatccg
     7861 ttggtccggc tgttgatccg gtttcagctc aaggcgtcct ggcgctgagc gcaggcgcgc
     7921 agtctgctga tcgcgcgatg tttggtcacc cgcacccgtg acgaggtcgt cccgagcgcc
     7981 gccgcggtct cgttcgacgt cagctcgccg atcacccgca tccccagcac ctcgcggtgc
     8041 gagacgggca gcatccgcat cagcctgccg aggcggaccc cgaggtcggt ccgcagcgcg
     8101 cgctgctccg gttcatccgc cggtccggcc gggcgctcgg ggagttcgcc ggtcagcacc
     8161 tgcttgctcc gcgccgcctt ccggaagacg tcggcgacct tgttcgccgc gatggcgcgc
     8221 aggaggaaca ggaaggaacc gccgcgtacg ccgtatccgg ggacggcgac caggaccgcg
     8281 agacagatct cctgggcgac gtcggccggt tcgaggtacg tcagctcatg gccgccgagg
     8341 cgggtctcgg tgtactggcg tgcccacgtc gcgacggcgg ccatgaggtc gtccatgccg
     8401 tgcggctcgc cgtccgccgc ggccttggcg aggccgtccc aggaggcggc ggaaatccac
     8461 gtctcgccgc cgccggttct tcgcatcgga aattcgtcgc tcatgtcccg ctccccacgg
     8521 atgagaaaac ccggccgccg gggtccagga cggaacccgg acaacggtag tcgaggaatc
     8581 cggccacctc aatcggcgaa ggcccgcgac gaattgtccg tcccggcgca aaaccggaca
     8641 gattcccacc agtggtctgg acatgtcggc ataccgcgac gtaacttccc gtgctgagac
     8701 ccctcgccaa ggtcacgccc aggccgggaa cgcgcccccg gccgacatcc gcaagcaccg
     8761 ccgcggcgcg tccacgctcc gcggcgggat tccgccgagg agtgaactgt gcgcatccgc
     8821 aagaaagtcc ggcgcgtttt gaccgcgttg gcggtcgccc tccccctggt caccggtgtt
     8881 tcggcgcttt cggcgtccac cgcggccgcc gccggccccg atccgctgcc gctgaccgtg
     8941 acgaacaatt cgaaccgctc cgacgcggtc cacctctacg tgctcggcac gaacctcgac
     9001 accgggaaac tcggctacgt caacgccgcc ggcgccttca ccgcgtggcc gccgggcgcg
     9061 aacccgccga gccccgcgcc ggacgtctcg atcgcgggcc ccggcaacgg cggctcgacc
     9121 acgctgcgga tcccgcgcat gctctcgggc cgggtctaca tgtcgttcgg gcagaagatc
     9181 aagttcttcc tcaccccgga cggcctggtc cagcccgcgc cgtgggccga cggcgacccg
     9241 aaccgcgaca tcctgttcga ctggagcgaa ttcacctacg acaacggcgg gctgttcatc
     9301 aacagctcgc aggtcgacat gttcagcgtg ccgcacgccg tcgggctgac caacggggcg
     9361 ggcgcgaaca aggaggccgg ccgtttgaag cccggtggcc gcgagaacat cttcaacgcc
     9421 gtccagggcc agtccgggtt ctcgaacctg gtgtacaacc ggctgcgggt cctcgcgccg
     9481 ggcaaggggc tcgacaccgg caagttcagt ggcaactacc tcgacggcta cgtcactagc
     9541 gcctggaaca cctacaagtc gacaccgctc gccgtcgtcc cgttcgaggc cgaacccggt
     9601 aagaagttca ccggacggac cggcggggac gacgtcctgc gcttcaccga cacctcgggc
     9661 gccgaagtgg cgtcgttcag caagccgagc acccgcgacg tcttcaactg cgacggacgg
     9721 ctgcacgcgc cgaacgacca ggtcgtcggc ccgatcgcgc ggaccctgtg cgcggcgctg
     9781 caccgctcga cgctcggctc gctgcacact cagccgacgt acgacgcggg ccagttctac
     9841 aagcagtccg tgaccgacca ctactcgcgg atcgtgcacg agcagatggt cgacgggaag
     9901 gcgtacggct tcgccttcga cgacgtcggg cacttcgagt cgctggtgca cgacggggat
     9961 ccgcggaccg cgcggatcac gttgaccgct ttctagacga tcagcgcgcc ccgctcccga
    10021 tccgccaagc cgacatgccg atcccgctcg gcacgagcga gaacaccggc ggctcgggag
    10081 cgtggacgcg cgccagctcc tccggcgtgt accgcacgca tttccggtgc cattccagga
    10141 ttcccgccat ccagtccttc aggtggtccg cgtacccggt gaccgccgcg cggacatcgt
    10201 cgccgagccc gaggtcgtcg cacatccgcg gcaggtcctc gtcggcgagc tgctcgaact
    10261 gcgtcatccg cgcgttgccc agccgggcgg cgatgtcgcg ggcctcgttc cggtcgacgt
    10321 ccaggaaccg ctcggcgacg tacacgaggt tgtgcgtctc gccctcgtat tcgatctcct
    10381 tctggtacga gaacaggtcg ttggagaacg ccgcgtagtc ctgcgccgcc gtgtcgagtt
    10441 cgaacagcac gcggttgcgg aagagctcgg cgggcacgac gtcgccgagt tcgaggagcg
    10501 cgaggctctt ggtcagatcg gagccgaacg tccggcggcg catctccacg tagtcgaccg
    10561 ggtcggggac gcggttctgc gcctgattcc cgacctccca gacccagctc gcggtcatac
    10621 tctcgaccgc ctgccggaac cccgcgcgcg tgcgagggga cagcggtccc gcggtgcggc
    10681 cccacaggtc cgcgaggccg acctcgatcg ggttcgacgg cttcggcacc ggctcacctt
    10741 cgagcggcat gaacagggaa agccggtcgc tgcacagttt cgccgcgacc gcgtcccgtt
    10801 tcgccccgaa gaccagcggg aagtagtcgt cgccgaacgt gccccaagtg agccagtcgg
    10861 tcgacagttt cagcccgtcg aggtccgcgt ccgggtcgat catcgcggcg caatacgcga
    10921 ggtcgagccc gcggaaccgg cgctcgtccc agaccccgcc gtcgagcatc cccatctccc
    10981 gcgcccagcc gggcgcgtat tcacgggcgg cggcgagatg ggggctggtg cgcacgggat
    11041 acggcatgcg gaattccggc aacggcaggt gcccggtctt cgcgaacggc ggcggcgcct
    11101 gctggcgtat ccgccggccg aggcccaggc tgtcggtacc ggagtccgcg ccctcgttca
    11161 tgtaccggct cgaccgggtg tgccattcgt gaccgccgga ctgccagtcc tgcaggcctt
    11221 tgacgtacag gccgaccgcg atctgctcgg gcagcgagac atcgcgctcg gcgagcaacg
    11281 cgggcacctc gacgagcgcg gtgttctcga actgctgcaa tcgcgaggtc aggaggtcgt
    11341 tggtgagttc ggcggcttcc tgcgtcgggc agtcgaggaa cttctcgaag acgaggacgg
    11401 cgttggagtt ctcgccctct tcgcgcactt cgcgttggta ggaaaagaga tcgttgcgaa
    11461 ggtggacggc gtcggcgaac gtgtcgcgca gtacctccat cggcctggtc gccgcgatcc
    11521 cgtcgggcac ctcggcgccg acggcgaact cgatgaggtt cgccgaccac ggcgccccgc
    11581 cgacacgacg ccgcatctgg acgtattcga tggggttcgc gatgcggccg cggtcgatgt
    11641 tgtccagttc ccagagcgat tcgaccatca gattgtgcgt gctggtgacg aatcgccgtc
    11701 gccaggcctc ggacatcgaa ggaatggtgc gcgcccaaag gttttcaagc ccggcttcgg
    11761 cgggattcgc cggttccggt gatgtttccc ccggcccggt catgaacagt tccaagcggt
    11821 ccaaataggc cttggcgccc tcggtgtccc gggtgtactt gaattgcgcg aggaaatcgt
    11881 cgtcgaagaa gaacacccac acgtaccagt ccgtgaccag atcgagggac ggcccgtcac
    11941 agtccggatg ggtgtgcgcg cagagcagcg cgtaatccat tttcgccagc gcctgctcgg
    12001 tccagacgac gtcaccggac ggcgacggcg aatcgagcat ccccatttcc ccggcccagg
    12061 ccatactgtg cgcccgcgcc gcttcgaggt gcggattcat cctggccgga tggggcaggt
    12121 agaactcggg caaggtgaaa gcctgcatct gcgactgcct cccgggccgg ggtcggatcc
    12181 gttccgacgt ttccagcccg ccgccgcgct gggcaaccgt ccagccgagc gattcggtgt
    12241 gccatggagt gaatcagtcc cagagtgact ccggatcgac atacggcacg agcaatccgg
    12301 tcaatatctc gtcgccgttc ccgttcaatg cgtcctccgc gatccggcgg gcgacgccga
    12361 cgaggaaatc ggcgacctgc acccgcggat cggtccggga atccacgaac ttcaccccgg
    12421 ccaatcccgg actcgactcg atccgggcga gccggtcccc tttgagcgac ggttgttcgt
    12481 catggacgag gaagaccggc tcccctcccg cgctccagta ctcgatggcg cggaggatcg
    12541 cgggcaccag cggatcgagg ctcttggcgt cgcgcgtccg gccgaccttc gcccgcaatt
    12601 ccgcggtgtc cccggccatc gcgaagaacg accccgccgc cggatcccgg cggttcctgg
    12661 tccgcagcac gtcgttgaac gcggcgagga gctcgtcgtc cggccggatt tcgggcccgg
    12721 cgagcgcccg gagttcgttc gccagcagcc gtttcttgtc cacgaggtac acctgcgcac
    12781 gcccgtggac cgggccgcgc ggaccgagga accattcgag cacccgccgg tgcttcgtgc
    12841 ggaggaggtg gttcgccttg tactcgagcg ccggcgagcg gatccttcgc cgcagctcga
    12901 ccaggcaagc cgcggtctct tcgaggctca gccggacccc cgcgtgcgcg aacacgccgg
    12961 tccggccgcc gatcagtttc tcgccctcgg acccggactc gtcgcaggcg atctccaggg
    13021 gcacgctgcg catcgtgccc gatcgcgagg gccgggtcga ccgggttacg cgggttcggg
    13081 cagcggctcg ccggtctcca gcagcgattt gaggctcgac aggatcgacg gccagccgcc
    13141 cttgaccatc tccagcgcgg tgctgccctg gtcgaaaccg tcgtgcacca cggtcagctt
    13201 caccatgtcg ccgacgggtt cgaggtcgaa cgtcaccttc gaccgcgact cggcctggag
    13261 cttcgccgac acgtcgtcgt cgagcccgac cgacttggcg aactccggcg tgaaggtgtg
    13321 ccaggtgtag gacagccgcc gatacgggtc ggactcgagg acgacctgtt cgggatcctc
    13381 cagcttcacg ccgagttgct cccaggccat cgtcgacccg gccttccagt ccgaggtgaa
    13441 ctcgcaaccc cagtaccgct tggtgaagac cggatcggtg agcgcctgcc aaagccgctc
    13501 cggcgtcgtc ctgatgtagc tggtgtacac gaattcgtcg gtgctcatgg gttcctgctc
    13561 caatgccttc ttgaggtcgg cgagcgcgtc gacccggccc tggtggtacc ggtcgatcca
    13621 gcgctcggcg atcgcgttga tcggctccgc gttcacgtag tgcaacttct cgcggccacg
    13681 ccacaccgtg gtcaccagat tcgccgcttc cagcacggcc aaatgcttgc tgaccgactg
    13741 ccgcgccatg tccagccccg cgcacagctc gcgcagggtc tgcccgttgc gggcgttcag
    13801 gtcgtcgagc aaccgccgcc tgctcgggtc ggccagcgcc ttgaagacct cgtccatgcc
    13861 gctctccctg atatgcagcc tcgcggctgc ctttgcagat taggcagccg cacggctgca
    13921 tgtcaagccg gctgctcagg gttctcaccg agcacgcgcg gacccgggac caggctcagc
    13981 cagtcggttt ccacacgaag aagacgcgaa taccacggtt tccctcgcga catcccctat
    14041 tcatgaaaca gcctcggtat cggaccgcca tctcccctta agggcgcctt tccgaggtct
    14101 cgggatatgc ccggatgctc ggcagaatcg gttccgacac gcttcatttc catgaaagcc
    14161 gattcgcgga cgaaacacgc cagacggttg ttgctgtgcc tccatgtgct ggcctcggtc
    14221 gcctggtgca cgatgcagct ggcgcagctg gccctgttgc tgcgcggctg gtcgtccgac
    14281 ggccccgccc gcctggcgac cttcgaactc gccgagttcc tcgagaacac ggtcctcgat
    14341 ccggcggcca tcgtttccgc ctacaccggg atgatgctct ctgcgctgac gtcatggggt
    14401 ttcttcaaac atcgctgggt gatggtcaag ttcgtcatca cggtcgcctt gctggtcatc
    14461 gcgagcacgg tggtgagcag gctgctgccg tcggtcgtcg aggcgttgcg agccggagcg
    14521 gaagagccgc ggatcccgat cctcgtcgga acgtgcggga tggcgtgcgc caccgctttc
    14581 ctgctctggg tctcggtcgt caaaccctgg gggaagaccg cccgccacgc ggcggaattg
    14641 aaggccaaga aagcacgggg ccgcaaagaa ccggaaccgt cgctgccggt ctacgtggcg
    14701 gtcttgctca ttcccgcaat cgagttcggc ttcgcactcg actacccgat cctcactttc
    14761 ggaacggtga tcggctacag catcttcaaa tccgtttcac gccgctcgca caaggccgaa
    14821 ccggccgcga ccgcctgagc taaccgccgg agtgggtgat caacgccggc gtctccgtca
    14881 cctgaacagg gtcaccaggc cgcagcggcg tgaccgtccc atcgagcccg gtacgcgact
    14941 cggcgcccgg acccgccgtc gtgaacgcgc tccccgagtg cgtccagcgg atcgtcagca
    15001 agcgatcggc accgtcgacg aactcgcact gccagacgtt cgcgggcagc ccggccggaa
    15061 gtccctgcgc gcacccgcgc agccgagtgc ccgccagcca gcgttggagc gtctcgaccg
    15121 cgagggccgc gcgggtcggc ggagtcccct cgacctgcag caccagcggc aggcggctcg
    15181 aaccccagtt gtagaagtac atccggcgca tgccgaactc cctgccgtac agcccggcga
    15241 ggtagaaccg cacggcatga tccacggaac gcttgggaga cagacgttcc tggagcggga
    15301 tgtcgtaagt ggtgcccgtg ttccatagcg gcggatggac gccggccgcg tgcatcgtgt
    15361 cgtcgatctc ccgtaggagg ttgacgagcg tctccggcgg atcggccgga tgtcgttggt
    15421 gcagcttgac tcccgcgacg tcgcagtggt cgtaaccgcc gagttccgcg aaccgcttca
    15481 gcgtttcccg cccggccggc tgccagagct gtcccatcga gggacacacc agcgtggcgt
    15541 ccgggtcgaa ggagcgcacg atcctcgcgg cccggcccgt catctgcacg agtgtctcca
    15601 ccgaacccga gtaatacttg ggattcgacg cctgaaccca cagctcgtag gcatcgagcc
    15661 tgccccgata gcgggaaacg agggcttcga cgaagcggtc ccagtccgcg aggttctccg
    15721 gcgaaccggt ccgcgacccg tcggtgtacg cgcccttcgg cgagttcggc gccgcccaac
    15781 ccggtgtccc gccgaggacg aacagggagg gcaggcctgc cttttccgcg ccgtcgacca
    15841 accggtcgag tgtggcccag tcgaagcggt cgcgggcagg ctgcaggttc gcccagcggg
    15901 tgtggctgtc ccagaaccgc accccgccga cccggaacgc gggcatggtc ccggtgtcgc
    15961 tgttcatcgt cacgccgaac agctccgggg aaacctcaac gggctccctc acccacggag
    16021 ccgcggagag cgcttcgacg ctcgcgtcgg cacccgtgcc cgaaggcgcg ctcgcggtca
    16081 cgacgagcac catcagcacg acgagcacgg cggcgatcgg ccggccccgt cgccggggct
    16141 gcggctccga caccgcgatc ggcacgggag cgggctccgg ctccggtgcg tcgtccccgc
    16201 gacgacgcca ccgacgcacc agttcgttca gctcgtcgtc ggtcgcaccg cactccttgg
    16261 cgatggcggc caccagctgg tagtcgggcg gctcgctccg gccggtgcag tagcggtgca
    16321 gggtcgagct gctgacgtag gtccgtctgg cgagctcggc gtagctgaga ccgctgcgct
    16381 gcttcaacgc cgacagcaat cccgccagat cgtcccgctg ctccgccatc cggccccctc
    16441 cccgaaagct tgtcacggcg catcccatca caacggcgaa accgctgtac aaggcccata
    16501 tcgccgtccc gggacgccgc gggccttccc accggcgagc gcgatccgtc agggtttcgg
    16561 cgtagcgacc acagagttcg acaaggggag aaaatgaaca agagacgtgc cgtcctcgcc
    16621 gccgcggccg cgccgatcct ggcgatgacc gccgccgcga cacccgcgca ggccgacgcg
    16681 cccatcacca tccagggcaa ctgcacctac ccgggcctcg ggcaggaact gtgcggccgg
    16741 gtgatcaacc acaaggactc cgagaagtgg ctggtcgtcg ccgacggctg gaactgcggc
    16801 ggcagcggaa cggcctgcgg cgacaaggtg cggctgtacc ccggcgacct gtccaccgac
    16861 agctacaagg acgccgacgg cgtctacatc ccgaacggct gcaccggcca cctcggtctt
    16921 cgcgagctca agggcgggaa gtggacgaag atctccgaca gcatcggcta ctacaaggtc
    16981 aaggtgaagt gctgacgccg gttccctgat cgaggcgttc gcgggcgtgg gggctcgcga
    17041 acgccttgtc acgtttcccg cggctccctc gtcgaggtgg tgacacgtcc actcgaagga
    17101 gttcacatgc cgaccccgtt gcgcgtcgcg atcgccgtgc agaccctggc cgtcttcctc
    17161 accccgatct ccgccggtct cctgctgacc gtgccgagtg gccacaccct gcacagcgcc
    17221 acggcctaca cgctgttcag cgtctcgatg ctgcacgtgc tcgtcgcggt cctcgtgtgg
    17281 cggccgggcg gcggctccgc caaaccgatc ctgcccgcgg ccgtgttcct cggtctcacg
    17341 ctggtgcagg tgttcctcgg gattgcgcac gtgacggcgg tccacgtccc gctcggcgtc
    17401 ctgctgttcg gcttcagcct cgtgcagctg agccggatcc ggcccctgcc acgggaagcg
    17461 gcggcgcctt gatgaccgcg gtgaaagtct gccgatccat gcgtccctcc acccgagata
    17521 cttgaacgcg caaccaaatg cgagtactag tggcaccaag gccgatacgg tccgtccata
    17581 cctcagggga gtatcgatgc gtcttgggtt cagccttccg gtgttcggca aggcggcggc
    17641 cacaccaggt gggatcgcgc ggtacgcgcg tacggcggag caggccgggg cggccagtct
    17701 ctgggtcggc gaccggttgc tgtcgccggt gaacccggag gtggcctacc cgggctacga
    17761 caccatgccc gaggagtttt ggaccgccca agatccgttc accgcactgg ccgtcgcggc
    17821 cgccgtgacc gaaaccgcga tcctcgggtc cagcaccatc aacgcgacgc agtaccagcc
    17881 cgccaacttc gcccggctgc tgaccagcat cgacgtggcc agcaacggcc ggctgctccc
    17941 cggcctgggc atcggctggt cacccgacga atacgcggcc gtcggcgttc cgatggcgga
    18001 acgcggcaag cggctggacg atctactcga tcttctcgac acctggtgga ccaaggacac
    18061 cgtgtcacac aacggcatcg gctacacgat tccggagacc cacgtccacc tgaaaccggt
    18121 acgcaagccg cccgtacacc tggccgggtt cggcgagagg gcactgcgcc gggtcgccga
    18181 gcgggcggat ggctggctgc cggtctggac ggtgcccgaa accatccccg ccgacatgct
    18241 cacctccacc ctggccaaga tccgggccga cgccgaacaa gccggtcgcg acccgcggac
    18301 actgggcgtg gcgctgcgag tgaatgccgc cccggacacg aagccggaac tcatcgccga
    18361 gtcggtgacg aagatcgtcg cgacacttgc gccggaccac accttcgtcg acctcaccta
    18421 cctgaccagc agcgtggaag aacacatcga cctcaccggc cgcctgctgg aactgaccgc
    18481 catgggctga ttcccgacgc ggcgcggacg ggagcagcac ccgctgccag gtgacgacgg
    18541 agatcgacct cgacagacgt gtcagcccca caaaatgttc acacatcgtc gtcctacgtg
    18601 ctgcaacgca cggacggggg gtggcgccca gtcacagacg ggatatccgc actcatgctc
    18661 cgcacaaacg agatccagcg gtacgttgcg cgcctgagcc cgccggcccc caggctgagc
    18721 actgacatgt acgaggccat gcatacgaat gaggagattc gcgacgagct ggccagccgc
    18781 atggtgctcg ccgcgctccc gacgttcttg accactgcat tcgagaagaa cgctggcgac
    18841 ctgatcagtc atcactgatc acgtacgtct tcaccgcatg ggtcagaggc tggttacgac
    18901 tccggtatga ccaagacacc ctgccgagtt ccgaagctca tcaacaccca gaactcgaca
    18961 gatcgccacg actctcgcca tcagcgtcag cgctgtccag aaccgcctct accgcttccg
    19021 gcggtccgtg gtcgccccag ccctgcgacg atccggaacg ccgtccggcg cgacgtcatc
    19081 ggtcgcgatc gaccgactgg gccgactcgc atgcactcct cgctcggccc gccgcggcgg
    19141 ccactggaag gaacataaat ggctacgctg tagctgatat tgtcgggccc ggtcaatcct
    19201 ggacgcactt tgacgcgtgt caccatcgtc gaacagccgc gacgcgacct cgaccggccg
    19261 acgcgcccag gtcgccttcg cgatgcaact gaacccggac cggttccccg ttacggtcgc
    19321 cgtcgccgac gcactcccgg cgccaccgga ggacgcgttc gaattcgggt tgcgactgat
    19381 catcaccggc cccggcgaac tccgtcaccc cgctggcgcc gacgacgtca ccgggcggca
    19441 gcgtgcagct gacgcagccc gttgacgatc aactccagac cgaatgcgaa ctcgtcctcc
    19501 agcggcaccg gcagggagtc cgcaaccctg cgcgtggccg ggaagtcgac ggacgacagg
    19561 tcgtggaacc gcgccgacac ccgctcctgc tcggcgccgt tcccagaacc gacgagctgg
    19621 atggcgaaac cgaggacgta gcgcgcgagc gtggcgtagg cgcgcgccgc gaggctcggc
    19681 ggcaacccgc cgtcgagcag gacggccagg cagcgttccc gcagcaccat cgcgttcggt
    19741 ccggtcgggg tctgctcgat cagcaggggc gcgatctgcc ggtgccggcc cagcgtgtcg
    19801 aacatcgcct gagcgacggc atggcaggcc tggtcccagc gcagctccgc cagcgtccgg
    19861 gagtcgagtt cgatctcgcc gaacacgcgg tcgatgacgt ggttgatcaa cgtcgcccgg
    19921 ttgccgaagt ggcgatagag cgtggccgtg ccggattcga gtcgttgagc aaggctgcgc
    19981 atcgacagcg cctcggcgcc ttcctcgtcg acgagctgca acgccgcggc gaggatccgg
    20041 tccagcggga cagcaggacg gccccgcgat cgtcgtgcga acgcggcggc ttcggttgac
    20101 agggagggtt tcgacacacc cagaagtatg accacaggtt gacacccacc gcaataacgg
    20161 caacactgtt gccattatga agagcaatca cacccggtca gtttcggtcg acggcgtgcg
    20221 cgttcactac gaacgcgcag gtcaaggccc cgctgtggtg ctgttgcacg gcagcgggtc
    20281 gtcattggag ggcttcgagc gggtcgcgga gctgctgtcg gcgtcccacg acgtcatccg
    20341 cccggacctg cccgggttcg ggcggacggg gccgcggccc gaccgcgact accgcgtccg
    20401 cacgtacgcg ggcacgatcg cccggttcat gaccgcgctg ggcgtgccgc agttcgccgt
    20461 ggcgggcaat tcgctgggcg gcaacatcgc atggaacctc gcgctggatg cccccgagcg
    20521 ggtggatgcg ctggtgctga tcaacgccac gggctacccg gagaagacgc tgcccgccgg
    20581 gttgcggctg gcccggaatc cgttgctgcg cccgctggtg cggcggtggc tgccgcgcgg
    20641 cgcgaccgaa cgcgggctgc gcgaagccgt cggcgcgaac tccgcgatcg tggacgacgc
    20701 catggtcgat cgggtgcacg cgctgaccag ccgcccgggg aaccggtcgg cgttcgtcga
    20761 cttcgccaac accgaccagc ccgaccgcag cggcgacctc ccgaagatcg cggtcccgac
    20821 gctggtcctg cgcagcgcga gcgtcgatgg gcagcacttc gcccgcgaca tccccggcgc
    20881 ccacgagcgc gtacacaccg gcggtggcca tctgctgccg gaagaggacc cggactgggt
    20941 ggccacggcg atcagggagt tcctgcgatg aagtacttcg ttgcctccga tgaggatcgc
    21001 cggcttgacg cggccacgcg ccggaccctg cgcggtgact tcgtcgccct gtccgacggg
    21061 gtgacgcact acgagctgac cggccccgag gacggggagc tcgccgtgct ggtcggcggg
    21121 atcacgatcc cgttgtccta ttgggacgga ctcgccgcgc ggctgcacgc ccgcggtctg
    21181 cgcaccctgg cctgcagcgc ctacggccgc ggctattccg accgggtccg gggccgctac
    21241 gacgaggctt tgttcgtccg gcagctggcc gagctcaccg ccgcgctggg cctcaccgga
    21301 ccgcaccacg tcgtcggcac gtcgatgggt gccctggtcg cgatggccta tgcgaaccgg
    21361 gacccggcga ccgtggccac gctcacgatc gtgggcccgg ccgggctggg tgcgcggccg
    21421 ctgccgcagc ggttgctgcg caacgatctc atcgccggat tcatcgcccg gcgcttcggc
    21481 cgcaacctcc tggaagacca cctcgggcac aacgtccgcg accccgggct ctccgcccgg
    21541 ctggtcgcga tggtgcagga cgcctaccgc tacgaaggct ccctctacgc gttcttccag
    21601 accctgcagg actttccgct gcacgaacgg aaggacctgt tccgcaggac cggcgagctg
    21661 gggcttccgg tcctgctggt gtggggcgac gacgaccagg tcaccccgat cacccacctc
    21721 ggcaccgtcc acgagttgct gcgcccgcgg cagacgcacg tgatcaccga atgcggccac
    21781 atggccccct acgaacggcc ggacgacgtc ggcgacctgc tcgcgtcgtt caccgttcct
    21841 cacccggaac ggctcgaacc atgaacgaca ccctcgacgt cctgatcgcc ggcgccggcc
    21901 cggccggcac caccctggcc atcgacctgg cccgccgcgg cctcgcggtc cggatcctcg
    21961 acaaggcccc gcagtccttc gacggctccc gcgccaaagg cctccagccc cgcaccctcg
    22021 aggtcttcga cgacctcggc gtgctcggcg acatcctcga cggcagcagc gactaccccc
    22081 gcctgggtat tcacctgggc ccggtcgccg tcccgtggcg gatgttccgc aaccgcgacc
    22141 gcaccgcc
//
