LOCUS       NZ_LIWC01000001        23120 bp    DNA     linear   CON 28-MAR-2024
DEFINITION  Amycolatopsis sp. CB00013 scaffold1, whole genome shotgun sequence.
ACCESSION   NZ_LIWC01000001
VERSION     NZ_LIWC01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Amycolatopsis sp. CB00013
  ORGANISM  Amycolatopsis sp. CB00013
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 2203332)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2203332)
  AUTHORS   Yan,X., Ge,H., Hindra,F., Yang,D., Huang,T., Crnovcic,I. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-AUG-2015) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2014
            Assembly Method                   :: CLC Genomics Workbench v. 7.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905755.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:05:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,488
            CDSs (total)                      :: 8,430
            Genes (coding)                    :: 8,383
            CDSs (with protein)               :: 8,383
            Genes (RNA)                       :: 58
            rRNAs                             :: 1, 3, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (5S, 23S)
            partial rRNAs                     :: 3 (16S)
            tRNAs                             :: 50
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 47
            CDSs (without protein)            :: 47
            Pseudo Genes (ambiguous residues) :: 0 of 47
            Pseudo Genes (frameshifted)       :: 17 of 47
            Pseudo Genes (incomplete)         :: 38 of 47
            Pseudo Genes (internal stop)      :: 1 of 47
            Pseudo Genes (multiple problems)  :: 9 of 47
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:01:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1841824
            Orig. end                         :: 1864944
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LIWC01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23120
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="13"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..23120
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23120
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13120](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13120)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    549..563
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.37"
                     /tool="antismash"
     misc_feature    770..784
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.6"
                     /tool="antismash"
     gene            complement(1054..2325)
                     /locus_tag="AMK34_RS08300"
                     /old_locus_tag="AMK34_08245"
     CDS             complement(1054..2325)
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="other (smcogs) SMCOG1087: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020636870.1"
                     /locus_tag="AMK34_RS08300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_08245"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_073844092.1"
                     /sec_met_domain="DAO (E-value: 1.4e-07, bitscore: 28.3,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAASQSFEVVVVGGGLGGLCAALSLRQRGLRVTVVEAAPALGEIG
                     AGIQTAPNASRILIGLGLRARLERVRTEPQDQVRRRWADGSIIAQLELGGRVTDQYGAP
                     YWHYHRADLHGVLLDACLDPDGIGPVVRVATGARVVDLDRTVPDRPAVIAADGRRFTGD
                     LVIGADGIRSSVRDLAGFDDTLAFSGEMAYRALISGDLIAQDPATRFLSDRYHSTIWYG
                     PNKHLVHYMIRGGEYLNVVAIVPCTETVEKDWSGPATAAELAAEYHDWDDRVPTMLAKA
                     KDEDVSVWAMYRRRRDPVWVDGRVALLGDACHAMLPYQAQGASQAMEDAAVLAEELGRV
                     TRDGIDGALVRYVDRRAKHAGMVQDASLQNMDFYHLPDGPEQRERDEKLRRFDGESDVS
                     YDWLWNGSPLTDPDTESIHYQFAR"
     gene            complement(2303..3100)
                     /locus_tag="AMK34_RS08305"
                     /old_locus_tag="AMK34_08250"
     CDS             complement(2303..3100)
                     /GO_function="GO:0036361 - racemase activity, acting on
                     amino acids and derivatives [Evidence IEA]"
                     /GO_process="GO:0006807 - nitrogen compound metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016335107.1"
                     /locus_tag="AMK34_RS08305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_08250"
                     /product="aspartate/glutamate racemase family protein"
                     /protein_id="WP_073844093.1"
                     /transl_table=11
                     /translation="MTDHHIGMIVPSSNLTMETELPRMLRAREEAEPGDRFVFHSARAR
                     MRHVEPEQLRAMNAQAGRAAAELADAKPDVVATACLVAIMAQGPGYHCTAEDDITRVLR
                     EEGCDAPVVSSAGALLSGLEALGARKVAIITPYLKPLTKAVADYIEDAGFEVADALSLE
                     VPDNLAVARLDPAGLREHHRKLNLSDVDTLVLSACVQMPSLPAIQPVEDEIGIPVLSAA
                     TATTFRILTELGVEPTVPGAGRLLSGAEALTKTGGGHGRESVV"
     gene            complement(3097..4143)
                     /locus_tag="AMK34_RS08310"
                     /old_locus_tag="AMK34_08255"
     CDS             complement(3097..4143)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009077317.1"
                     /locus_tag="AMK34_RS08310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_08255"
                     /product="leucyl aminopeptidase"
                     /protein_id="WP_038512165.1"
                     /transl_table=11
                     /translation="MDRNLFNDICLRQLTFSGVHEGETVVVLTRGGERAEYADAFLWAA
                     QQLGASAYHMRLPSPVSAAGAWAVGDSGLGNIPLAVEALKSVDMVVDCTFLLFSKEQFA
                     IQDAGTRILTAVEPPELLARLMPTKELRERVEIGAELLAKAGTMRITSPAGTDVTYQLG
                     VYPTLSEYGYTDTPGRWDHWPAAFVFTGGADDGVDGKIVLSPGDVLLPFNSYVQTPVEI
                     TIEQGFIRDIRGGAGSSGLDADLLRSYIESFDDPRGYGMSHVGWGLDERAHWHGLTQFP
                     GGMGMELRSFYGNVMFSIGPNNELGGPNDTPCHFDIPMRGNSLYLDDELIVDNGELTVA
                     EMRPAARR"
     CDS             complement(4177..4296)
                     /gene="allorf_1846001_1846120"
                     /locus_tag="allorf_1846001_1846120"
                     /protein_id="allorf_1846001_1846120"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MILRVRTVAHGKAAEICPQSPLAYPDSTCSYEARSCVPG"
     CDS_motif       complement(4264..4296)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MILRVRTVAHG"
                     /locus_tag="allorf_1846001_1846120_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(4177..4263)
                     /prepeptide="core"
                     /locus_tag="allorf_1846001_1846120_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.40"
                     /molecular_weight="2854.2"
                     /monoisotopic_mass="2852.3"
                     /core_sequence="KAAEICPQSPLAYPDSTCSYEARSCVPG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MILRVRTVAHG"
                     /leader_location="[4263:4296](-)"
                     /alternative_weights="2872.2"
                     /alternative_weights="2890.2"
     gene            4340..4840
                     /locus_tag="AMK34_RS08315"
                     /old_locus_tag="AMK34_08260"
     CDS             4340..4840
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1284:
                     transcriptional regulator, MarR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005163802.1"
                     /locus_tag="AMK34_RS08315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_08260"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_038512162.1"
                     /transl_table=11
                     /translation="MGEAARTGRLKGDTPAVTPAPPSDLLAAPGYGARRLYQAYLAAWN
                     RHVDPVLTGPQFAVLSAVRAYPGSDQSSLAGAVALDTSTMADLCRRLERRGLIRRVESP
                     HDARRKLLSLTDEGKSVLSQVNRRARRLDKALLDGDDDIDMAALLNALGARWERIAEVD
                     KLR"
     CDS             complement(4947..5177)
                     /gene="allorf_1846771_1847001"
                     /locus_tag="allorf_1846771_1847001"
                     /protein_id="allorf_1846771_1847001"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MKAPFIASDAAKGAFTPRPTRPPPPQKNHSHPELKAVKSGIHPRK
                     VSLVDGQTPQFRKMGQSGVLYGWTEGGFRCV"
     CDS_motif       complement(4977..5177)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MKAPFIASDAAKGAFTPRPTRPPPPQKNHSHPELKAVKSGIHPRKVSLVDGQTPQFRKM
                     GQSGVLYG"
                     /locus_tag="allorf_1846771_1847001_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(4947..4976)
                     /prepeptide="core"
                     /locus_tag="allorf_1846771_1847001_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.00"
                     /molecular_weight="1036.2"
                     /monoisotopic_mass="1035.5"
                     /core_sequence="WTEGGFRCV"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKAPFIASDAAKGAFTPRPTRPPPPQKNHSHPELKAVKSGI
                     HPRKVSLVDGQTPQFRKMGQSGVLYG"
                     /leader_location="[4976:5177](-)"
     gene            complement(5234..5875)
                     /gene="bluB"
                     /locus_tag="AMK34_RS08320"
                     /old_locus_tag="AMK34_08265"
     CDS             complement(5234..5875)
                     /EC_number="1.13.11.79"
                     /GO_function="GO:0016722 - oxidoreductase activity, acting
                     on metal ions [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0032363 - FMN catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="bluB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00881"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016335110.1"
                     /locus_tag="AMK34_RS08320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_08265"
                     /product="5,6-dimethylbenzimidazole synthase"
                     /protein_id="WP_038512159.1"
                     /sec_met_domain="PF00881 (E-value: 2.5e-28, bitscore: 96.1,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRDADDRSLYETIFRRRDTRGEFTGEPIPAEVLRRVLSAAHAAP
                     SVGLSQPWDFVVVSDMDLRKKFREHVLAEREVFEGGLDAERARVFAPIKIEGIVASSAG
                     IVVGYDPSRGAPDVLGRHAIADAGLYSVCLAIQNLWLAATAEGLGVGWVSFYREEYLRE
                     LVALPEHVRPVAWLCVGPVRDLPTVPDLERHGWRERLPLDAVLHYDQYSK"
     misc_feature    complement(5835..5851)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.77"
                     /tool="antismash"
     misc_feature    5864..5877
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.82"
                     /tool="antismash"
     gene            6034..6249
                     /locus_tag="AMK34_RS08325"
     CDS             6034..6249
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03898.1"
                     /locus_tag="AMK34_RS08325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="mersacidin/lichenicidin family type 2
                     lantibiotic"
                     /protein_id="WP_051972459.1"
                     /transl_table=11
                     /translation="MSEYDIVRYWKDEGYRAAVGGNILPANPAGIVELTDEALDSLVAG
                     AGAEMVLGSCLFVSCFNQPKPDAEQA"
     CDS_motif       6034..6195
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MSEYDIVRYWKDEGYRAAVGGNILPANPAGIVELTDEALDSLVAGAGAEMVLGS"
                     /locus_tag="AMK34_RS08325_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       6196..6249
                     /prepeptide="core"
                     /locus_tag="AMK34_RS08325_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-1.10"
                     /molecular_weight="1879.1"
                     /monoisotopic_mass="1877.9"
                     /core_sequence="CLFVSCFNQPKPDAEQA"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSEYDIVRYWKDEGYRAAVGGNILPANPAGIVELTDEALDS
                     LVAGAGAEMVLGS"
                     /leader_location="[6033:6195](+)"
     gene            6336..6869
                     /locus_tag="AMK34_RS08330"
                     /old_locus_tag="AMK34_08275"
     CDS             6336..6869
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK34_RS08330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AMK34_08275"
                     /product="hypothetical protein"
                     /protein_id="WP_073844094.1"
                     /transl_table=11
                     /translation="MAESIDQREQPPIFRAQAVAHHRRGRDEKGEPPELPAPALRRLWV
                     LLAALAAALLTGAATVPVTVYRQGDAIAVTGVEEPVVVVLPMSGAAEPAENAEVVLREG
                     TVRGRVVERFSGLSRAGLTARFGIPAADDLPEPAVAAVVRLDGATIRPGGRYPAWIEVG
                     TAPLLARLTGRTDE"
     misc_feature    complement(6337..6351)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
     gene            6862..9033
                     /locus_tag="AMK34_RS08335"
                     /old_locus_tag="AMK34_08280"
     CDS             6862..9033
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020647173.1"
                     /locus_tag="AMK34_RS08335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_08280"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_073844096.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 5.4e-39, bitscore:
                     129.9, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEPKRRRLRRRVPVVRQLTTTECGAACLAMMLGFFGRSTRVSEC
                     RELFGVTRDGITARSLVRAARAFGLSVKAFSVELTGFARLDLPVVAHWSFNHFVVVEKR
                     RRNGYLIIDPASGRRLIDDAEFAREFTGVALAMTPGPSFSRRSRDRSAVSVYLRQVLRL
                     PGWRPLLAQVLVVSLVVQLLVLAIPAVTKVLVDHVIPLHVTDVLQVVVAGIVLVVVTDL
                     VAGYLRASILIHLQSRFDTRIMLGLFGHLLSLPYGFFAQRTSGDLLLRLSSSGMIREML
                     TSQTLSVLLDGGFVLVFLAVLFTASPLFGSLALAIGAVQVLTLLLAARPLRELTQRYLV
                     AQADSQSFGVQVIRGIGSLKASGSEGQILDYWSSLFLEELRASLRRNRLTAVVNTVLHA
                     LRTFAPLVLLSVGAVSVLDGSMRLGTMLALNGVAVAFLSPLASLVTTGQQLHLAGVHFR
                     RIVDVIEATPEPDDAPVSDTALTGRLELSGVSFSYDPHGPRVLEDLSFAVEPGQKVALV
                     GRTGASKSTLAMLMLGLYRPTSGVVRYDGRPLEELNLRQVRSQFGVVLQEPFLFNGSIK
                     ANISLNDPGMSLERVVEAASLAGIRDDIERMPMRYDTLLGEGGGGLSGGQRQRLALARA
                     LATSPAFLLLDEATSHLDLATEALVDANLSALPCTRIVIAHRLSTVRNADLILVLEHGR
                     IVERGRHEELLELGGRYADLVRTQLAPTA"
     gene            complement(9012..10004)
                     /locus_tag="AMK34_RS08340"
                     /old_locus_tag="AMK34_08285"
     CDS             complement(9012..10004)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1251: luciferase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010232725.1"
                     /locus_tag="AMK34_RS08340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_08285"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_073844098.1"
                     /transl_table=11
                     /translation="MTIPLSVLDLAVLGTESTSAGVLAETTALARCADEFGYRRFWVAE
                     HHNMRSVAATSPPVLIAHLAAVTRRIRVGSGGVMLPNHSPLVVAEQFAMLEALHPGRID
                     LGIGRAPGTDPATAAALRRPDDADFPRQVRDVLGLLGDPRSREGIWDHFAATPVPTSMP
                     GVVLLGSGERGARLAGELGVPFAFAYHLRTSGGSFEPLRVYRDSFVPSAGLTAPYVLVS
                     VNVLVADTDAEADRLADPHRLRMLEMLAGVPPLLLRSPEAAAAHPHLGRARRLPLTLIA
                     GAPATAAEGLAELADATGADEFVVAPVARGEAAVRSLGLLSEAQAVGAS"
     misc_feature    complement(9642..9644)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(10001..13120)
                     /locus_tag="AMK34_RS08345"
                     /old_locus_tag="AMK34_08290"
     CDS             complement(10001..13120)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="AMK34_RS08345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_08290"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_073844100.1"
                     /sec_met_domain="DUF4135 (E-value: 2.9e-110, bitscore:
                     365.8, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 3.7e-54, bitscore:
                     180.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLDDSSWYRALSLAERLPVDGAGNGGEQARRRLVRWREQRPFDR
                     GDWFGRRLELDGITEAGLEALLGEDESALRDRSPSPSWLADLGVYADESHRDDTEPRGF
                     VVLAEPLLRKARVQVTAELTRLSAEGGPVDPGSAAHLVRTNVELGVAALVERTSVLELN
                     VARLRGDLDGESPADRYRAFLRDLREPATIDALFTEYPVLGRLLSEHVERRTVVLLEFL
                     RRLTADWSLLKESLFPSAEPGLLSRVEGHVGDRHRGGRAVLIASFTGGHRLVYKPKSLA
                     IDRHFHQLVDWLNARVAGLDLPTFAVLDRGEYGWTEFVEQRPCLHEREVAMFYRRLGGQ
                     LALMYALGGTDLHHENLIAAGGQPVVVDLESLFQPDLSRLVTAEPEDAAKQVALDSVLR
                     VGLLPQRAWGHDGAPGVDISGLGNREDQLTPRASPYWAAAGTDEMHVERKRMKVGGGHN
                     RPTLRGAEISVLDHVEDLLGGFRDVYRALAAERGALVTAGGRLDRFAVDEIRVILRPTH
                     VYSLLLRESTHPDLLRDGLDRDRFFDKLWVSAEHSGLPGAVIAAERADLWRGDVPMFVT
                     RPSSRDVYDSEGGRIPGLLDRSGLDRVRARIAKLSEADLEWQSWIIRGSLSALSVGDPA
                     AGPVRPPHGGRPRPRETGNHRAAAQAVGDRLEKLAIRHDHGVSWLGLTAFQERYWDLTP
                     LGADLYGGLSGIALFLAYLGDVTGQDRHTRLAEGALASVRFRLGRPELPSRQVGAYSGW
                     GGTIHLLTHLGVLWRRPDLLDEAVELAFRLDGSIDEDDQLDVLGGSAGLAGVLGGLYRH
                     RPDPGLLAIMRHCGDHLLATAQADDARRTLGWVTPLGPRPLTGFAHGSAGIGWALAVVA
                     ETTGDVRFADAASAALAHERALYDTASGNWPDLREDGGRAPMTAWCHGAVGIGLGRLAL
                     PAALRGPETRVEIAQAADTTAAAGTGANHSLCHGDLGALDLLTAAGHATAGERRAAVLK
                     DIETTGWLCGVPNHAETPGLLTGLAGIGHGLLRAADPARVPSILTLEPPS"
     gene            complement(13124..15001)
                     /locus_tag="AMK34_RS08350"
                     /old_locus_tag="AMK34_08295"
     CDS             complement(13124..15001)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015649.4"
                     /locus_tag="AMK34_RS08350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_08295"
                     /product="AfsR/SARP family transcriptional regulator"
                     /protein_id="WP_083649785.1"
                     /transl_table=11
                     /translation="MIFRILGPLEVWDDGARLPLGGPQQRTLLALLLLNANSVVSADRL
                     IDELWGAGAPSSARGLLKGCVAMLRRTLGVGRDERLLTRAPGYLLQVRPGERDLDRVEE
                     LAVIAKTDASRAAALLREALSCWRGPALDGLEGETCRAEAARLEELRLALFEDRVDAEL
                     RRGATPELVTELQPLVRRHPLRERLWAQLMLALHGCDRQADALAVYQRIRRALVTELGV
                     EPSSSLRRAHRLVLAGPAPAPAPKKDPPAITRAPVPAQLPAEIRDFQGREAELSELGRV
                     TAAAGTAVVSGTAGVGKTALALRWAHLARERFPDGQLYVDLGGHGPGRPVPPGAALSGF
                     LGALGLSEREIPVGLDDQAARFRTEVAGRRLLLVLDNAGWAGQVRPLLPGTPSCTVVTT
                     SRDSLAGLVALHGARRVGVGRLPLADAIALLRALIGDRADADPRSVSALAELCARLPLA
                     LRIAAEVATAEPDTALRELVDALAEPEDRLELLEVAGDPYASVREGLSWSYRRLPFDAA
                     RVFRAAGRAGTELDVGKTVAIAGLGLRAARRALSQLAAANMLDVVAPGRYAMHDLLRDY
                     AVCLPDDRSPAALRVLPGRVRTPGADRPHTRCRPPGLSVVTATTEKNGD"
     misc_feature    15118..15135
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.02"
                     /tool="antismash"
     gene            15194..18142
                     /locus_tag="AMK34_RS08355"
                     /old_locus_tag="AMK34_08300"
     CDS             15194..18142
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016335111.1"
                     /locus_tag="AMK34_RS08355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_08300"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_073844104.1"
                     /transl_table=11
                     /translation="MDFRLLGPVRLQVRGQNVAIGEPRRQAVLAVLLLEAGRTVGVDLL
                     IDRVWGESPPGQVRRSLQAHITRIRRALEQADPGGARVARDPGGYRLVARPEQVDVFRF
                     RRLLREHPTDVSRLSAALELWEGEPLAGLRGDWAERTRRTLRQEYTAAIVAWADAKIRD
                     GDAAATLTRLTELTDENPLQEPAAAALMRALYAVGRGADALTHYERILRALREELGADP
                     GPELAAVHEAVLRHDLPTASAAPAPVPAQLPADVAAFTGRADVLAELDRFLADGTGEEP
                     VLVCLTGTAGAGKTATAVHWGHRVRDRFPDGQLYLDLCGYAPGEPMPSSDALAALLSAL
                     LPEGTRMPPGQAERAARFRTEVASRRMLVLLDNAATLEQIRPLLPGTHTCAVVVTSRDS
                     LAGLVALHGAHRVDVDRLSEADAADLLRRLIGTRVDTEPEATAELAERCVRLPLTLRLA
                     AELAVSRPATPLSRLVGELRAAQQTLKLLSSGGDQRAAVRAVFSWSLRQLSEDTIRAFA
                     LLGRHPAPVFDSYALAALTGHSFDEARAVLDALVRAHLVHPTGDDRYGMHDLLKAYAAE
                     IESDEPAALDRVYGYYLATIAAAMDRLYPAEANRRPSVASPECAMPALDDADSARDWLD
                     AELPTVQALATAGRPEHAVTLSALLFRYLDGHHETAALAVHGHAIKAARAIGDRAAEAD
                     ALVAAGGLHMQAGRAVSAAADMWAAYALFGEAGNPLGQARALGNVGMIEESAGYYRQAA
                     DYYTRALALFHRLGDLTGQAHQLTRLGTVEARIDRREEGYEHLRQAMALHQEAGHRFGE
                     AWVKIGLGELAANEGGLADSCRLHAEAAALFGRLGHRGSEAWAIDGLGRAEALDGRPVD
                     AAAHHRQALDLFRRHGGRDGESWALNGLGEACLACGYPDTAGANHAEALDVATRYGCHE
                     QVARAHRGLARVASDPETVRDHYERAIARYAELGLPAAECTRTELAELSLSC"
     misc_feature    15206..15208
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(18255..19673)
                     /locus_tag="AMK34_RS43840"
                     /old_locus_tag="AMK34_08305"
     CDS             complement(18255..19673)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK34_RS43840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AMK34_08305"
                     /product="hypothetical protein"
                     /protein_id="WP_073844106.1"
                     /transl_table=11
                     /translation="MTNPLVATPKDSTTAVSGVPLLESATELKASIESGDWASVAVGAV
                     GTAMDAVSAALDPFGTILAAGVGWLMEHVGPLKEALDALAGAPDEIAAHAETWQNVAVE
                     LGSISADLDAMVVAETANWAGAAGDAYRTRGADVAALIGACQQAAGGAASGTKIGGEVV
                     TAVRTLVRDTIAELIGRLISWALQVLATLGLGMTWVLPQVTAAIAKTASKIATVVTKLV
                     KAMSALAPLMKKAKNIFAEAEKALRKIDTGKTGPAGKPRGPKPGGGDYSGTRGGGGGKG
                     KNSKPQPEQPPGLSPNLGKFDELTQAQKDAAIKMKQWIRDHKDSGQFGAWHNGVDDNKL
                     NSLGLGNKPTPGPGSTWGGRIYGNHGQAGGKLGNEGRLPHNGKTSDGKNHADQPFGPDG
                     KPTKPYDGKYYEFDVHPTPRYDNKPIRDADQYTDFNGKPLPENQRPKPDRIVMDDKGKF
                     YYAPGHYDKFYEVP"
     gene            complement(19670..20008)
                     /locus_tag="AMK34_RS08365"
                     /old_locus_tag="AMK34_08310"
     CDS             complement(19670..20008)
                     /GO_process="GO:0009306 - protein secretion [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005163148.1"
                     /locus_tag="AMK34_RS08365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_08310"
                     /product="type VII secretion target"
                     /protein_id="WP_038512139.1"
                     /transl_table=11
                     /translation="MSFQVVPAEIGKHAATVDGIAERLGTVLSAANTAAMSDEAYGLIC
                     AFVPPFINPAEEKTIDSIKAAIDGVKATAANLRTAERSYTEQDTAGVEMFKQYEAAIPA
                     TPKEKAQR"
     gene            complement(20108..20971)
                     /locus_tag="AMK34_RS08370"
                     /old_locus_tag="AMK34_08315"
     CDS             complement(20108..20971)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (22-142). E-value:
                     6.4e-29. Score: 93.2. Matches aSDomain:
                     nrpspksdomains_AMK34_RS08370_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020671044.1"
                     /locus_tag="AMK34_RS08370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_08315"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_083649786.1"
                     /sec_met_domain="PF00561 (E-value: 6.3e-24, bitscore: 81.8,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 7e-17, bitscore:
                     59.6, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPSSRRITVNGIRVNVAVAGSGPAVLLLHGFPHTWRLWSEIIGPL
                     SEHHRVIAPDLRGFGDSTRAAEGYDASTLASDIESLLDALGEPSAAVVAIDAGTPVAFL
                     LALRRPELVRRLVLMESLLGSLPGAEDFLAGGPPWWFGFHAVPGLGETVLIGHEAEYID
                     WFLASGTLGRGVAPEIRDAFVDAYTGGEALRCAFSHYRAMPVSARQIGEAVATRRLAVP
                     TMAIGAHPVGRALERQLRPVTDDLTAHLLPDCGHIIPLDKPGELLRLLTPFLADGQRVS
                     TVDRAL"
     aSDomain        complement(20546..20905)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMK34_RS08370_Abhydrolase_1.1"
                     /evalue="6.40E-29"
                     /label="AMK34_RS08370_Abhydrolase_1.1"
                     /locus_tag="AMK34_RS08370"
                     /protein_end="142"
                     /protein_start="22"
                     /score="93.2"
                     /tool="antismash"
                     /translation="PAVLLLHGFPHTWRLWSEIIGPLSEHHRVIAPDLRGFGDSTRAAE
                     GYDASTLASDIESLLDALGEPSAAVVAIDAGTPVAFLLALRRPELVRRLVLMESLLGSL
                     PGAEDFLAGGPPWWFG"
     gene            21070..21468
                     /locus_tag="AMK34_RS08375"
                     /old_locus_tag="AMK34_08320"
     CDS             21070..21468
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016335114.1"
                     /locus_tag="AMK34_RS08375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_08320"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_073844108.1"
                     /transl_table=11
                     /translation="MTPRRGDLFDPECPTRRLLDRIGTKWTSMAVKVLAEAAPHEVRFA
                     ELRRRIPGVSQKMLSVTLHSLVRDGLVVRRVEPTVPPRVHYGLTDLGLSLDVPLAALRD
                     WAEEHMSRIDEANAVSDAARKSSATGME"
     gene            21478..22191
                     /locus_tag="AMK34_RS08380"
                     /old_locus_tag="AMK34_08325"
     CDS             21478..22191
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016335115.1"
                     /locus_tag="AMK34_RS08380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_08325"
                     /product="DUF1345 domain-containing protein"
                     /protein_id="WP_073844110.1"
                     /transl_table=11
                     /translation="MRRARRETTLSRETARIWLPERRRSGLSLAFALLVAALAIAFGDD
                     VLSLASVDGGVLVLLAYLIGYLVVTVAAFGAATSEQIQDWACRESRGTFVQRYVFGTAP
                     GPGVSIFIAAAALAVAVVWMPGLGGESLPAGMRVGVAVALVVVAWICVLVSFAIAYHAD
                     NVVEEGKAMRFPDDGIAEWSDYIYFAVSVMTTFGTTDVDVVSREMRRTVTTHAIIAFVF
                     NTVTVAAVVSALNSG"
     misc_feature    complement(22238..22250)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.41"
                     /tool="antismash"
     misc_feature    complement(22538..22554)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.37"
                     /tool="antismash"
ORIGIN
        1 acgagcgaca gtgcggtgag cggaccggcg accatgatga tccgcttgcg gccgaccttg
       61 tcgaccagga gcacggccac cgcgacaccg acgatgccgg tcgcgttcat gagcgcggtc
      121 gacgcgaagg cggcgatctc gccgaatccc tgcgcccgca ggatggacgg catccagctc
      181 agcgcggcgt agtagaccag catgacgctg atgaacagcg accacgccac cgccgtgatc
      241 cgcgggttga acgcccacac ccggcgcagc tgatcgaacg cggccgcgac cgcgccgccg
      301 cgggtgtcct cgaccaccgc gggcgggacc gagtacggct ccggtgtcgc tcccgtgcgg
      361 cgcacgaggt cgtcgatcac ggcccgcgcc tccgcctcac ggcccttgcg caccaggtac
      421 agcggcgatt ccgggacgcc acgccgcacc cagaacagca gcagcgcggg caggatcatc
      481 aagaccagca tccagcgcca gttcccttgg accgggagca gcagcgtcgc ggtgacggcg
      541 gccagtgtgg tcccgatcgg ccaccagccg tccatcgcgg acaagacccg gccgcgatgt
      601 ttgcgcgggg agaactcgct gacgatcgcg tagtcgaccg ggatacagcc gcccagtccg
      661 atccccgcca ggaaacgcag cgccaggaac gtctccacgt tcggcgcgag cgcgcccagc
      721 acggagaaca gcgcgaacag cagcaacgtg acactgaacg cccgtttacg gccgatccgg
      781 tccgcgatcg tgccccagac gaccgcgccg acggccatgc cgatcaggtt cgcggtggcc
      841 accaggccct tcccaccggc ggacaagccg aattccgtcc cgacgagcgg ggtgaggaat
      901 ccgttcagcg cgacgtccca ggcatcgaac atgtagccca gcccgccgat gaggaagatc
      961 tttccctgca cgctccaacg ccagggcagg tcctggacga tctgatcacc agtacgcatg
     1021 aaccactccg atgcgattgc cggccagcgc gcctcagcgg gcgaactggt agtggatgga
     1081 ctcggtgtcg gggtcggtga gcgggctgcc gttccacagc cagtcgtagg acacgtcgga
     1141 ttcgccgtcg aagcgccgta gcttctcgtc ccgttcgcgc tgttcgggac cgtcgggcag
     1201 gtggtagaag tccatgttct gcagcgaggc gtcctggacc atgcccgcgt gcttggcgcg
     1261 ccggtccacg tagcggacca gggcaccgtc gatcccgtcg cgcgtgacgc ggcccagctc
     1321 ttcggccagc accgcggcgt cttccatcgc ctgggacgcg ccttgtgcct ggtacggcag
     1381 catcgcgtgg caggcgtcgc cgagcagggc gacccggccg tcgacccaga ccgggtcacg
     1441 gcgacggcgg tacatcgccc acaccgagac gtcctcgtcc ttcgccttcg ccagcatcgt
     1501 cggaacccga tcgtcccagt cgtggtactc cgcggcgagt tcggcggcgg tcgccggacc
     1561 gctccagtcc ttctccaccg tttcggtgca cggcacgatc gcgaccacgt tgaggtactc
     1621 cccgccgcgg atcatgtagt gcaccaggtg tttgttgggg ccgtaccaga tcgtggagtg
     1681 gtagcggtcg gacaggaagc gcgtggcggg atcctgcgcg atcaggtcgc cggagatcag
     1741 cgcccggtac gccatctcgc cggagaacgc gagggtgtcg tcgaagccgg cgagatcgcg
     1801 caccgaagac cggatgccgt ccgccccgat cacgaggtcg ccggtgaacc ggcgtccgtc
     1861 ggcggcgatc acggcgggcc ggtccggcac cgtccggtcg aggtcgacca cccgcgcgcc
     1921 ggtcgccacc cgcaccaccg gaccgatccc gtcgggatcc aggcaggcgt cgagcagcac
     1981 tccgtgcagg tcggcgcggt ggtagtgcca gtagggcgcg ccgtactggt cggtcacccg
     2041 cccgccgagc tccagctggg cgatgatgct gccgtcggcc cagcgacggc gcacctggtc
     2101 ctgcggctcg gtccgcaccc gctccagccg ggcgcgcagc ccgaggccga tgaggatccg
     2161 gctggcgttc ggcgcggtct ggatccccgc gccgatctcg cccagcgccg gggcggcctc
     2221 gaccacggtg acgcgcaacc cccgctgccg cagggacaac gcggcgcaga gcccaccgag
     2281 cccgccaccg acgacaacga cctcaaacga ctgactcgcg gccatgcccg cctcccgtct
     2341 tcgtcaacgc ttccgcgccg ctgagcaacc tcccggcgcc gggcaccgtg ggttcgacgc
     2401 cgagttccgt caggatccgg aacgtcgtgg ccgtcgccgc cgacaggacc gggatcccga
     2461 tttcgtcctc caccggctgg atcgcgggca gcgacggcat ctgcacacag gcggacagca
     2521 ccagggtgtc cacatcggac agattcagct tgcgatggtg ctcgcgcagc ccggcgggat
     2581 ccagccgggc cacggcgagg ttgtccggca cttccagcga aagggcgtcg gcgacctcga
     2641 atccggcgtc ctcgatgtag tccgccaccg ccttggtcaa cggcttcagg tacggcgtga
     2701 tgatcgcgac cttgcgggcg ccgagcgctt cgagcccgga cagcagcgca ccggcactgg
     2761 agacgaccgg cgcgtcacaa ccctcttcac gcagcacgcg cgtgatgtcg tcttcggcgg
     2821 tgcagtggta gccgggaccc tgggccatga tcgccacgag acacgcggtt gcgacgacat
     2881 cgggcttggc gtcggcgagt tcggccgccg cccgtccggc ctgggcgttc atcgcccgca
     2941 gctgttcggg ttcgacgtgc cgcatccggg ccctcgcgga gtggaagacg aaccggtccc
     3001 ccggctcggc ctcctccctg gcgcgcagca tccgcggcag ctcggtctcc atcgtgagat
     3061 tcgagctggg gacgatcatc ccgatgtggt ggtcggtcat cggcgggccg ccggacgcat
     3121 ctcggcgacg gtcagctcgc cgttgtcgac gatcagttcg tcgtccaggt aaagggaatt
     3181 gccgcgcatg gggatgtcga agtggcaagg cgtgtcgttc gggccgccga gctcgttgtt
     3241 ggggccgatg gagaacatga cgttgccgta gaaactccgc agctccatgc ccatcccacc
     3301 ggggaactgg gtcaggccgt gccagtgcgc gcgctcgtcg aggccccagc ccacgtggct
     3361 catgccgtag ccgcggggat cgtcgaaact ctcgatgtag gaacgcagca gatccgcgtc
     3421 gagcccggac gatccggctc cgccgcggat gtcccggatg aagccctgct cgatggtgat
     3481 ctcgaccggg gtctgtacgt agctgttgaa cggcaacaga acgtcgcccg gtgacagcac
     3541 gatcttcccg tcgacgccgt cgtcggcacc gccggtgaac acgaacgccg ccggccagtg
     3601 gtcccagcgg ccgggcgtgt cggtgtagcc gtattcggac aacgtcgggt acacgccgag
     3661 ctgatacgtg acgtcggtac ccgccgggct ggtgatgcgc atcgtgcccg ccttggccag
     3721 gagttccgcg ccgatctcca cgcgctcgcg cagttccttc gtcggcatga gcctggccag
     3781 cagctcgggc ggttcgacgg cggtgaggat ccgggtgccc gcgtcctgga tggcgaactg
     3841 ttccttgctg aacaacagga acgtgcagtc gaccaccatg tcgacgctct tgagcgcctc
     3901 caccgccaac gggatgttcc cgagccccga gtcgcccacc gcccacgcgc ccgccgcgct
     3961 gaccggcgag ggcagccgca tgtggtaggc cgaagcgccg agctgctgcg cggcccacaa
     4021 gaaggcgtcg gcgtactccg cccgctcacc gccgcgggtc agcaccacca cggtctcgcc
     4081 ctcgtgcacc cccgagaacg tcagctggcg caaacagatg tcgttgaaca ggttccggtc
     4141 catcgccgac cacctccata ttgatccgag cacgtactat ccgggtacgc aagaccgggc
     4201 ttcatacgaa cacgtactat ccggatacgc aagaggtgac tgcggacaga tctcggcggc
     4261 cttcccgtga gcgaccgtcc ggacacgtag gatcaccgcg ggggcccggg cagcgggttg
     4321 gagccgacaa ggagtagcga tgggtgaagc ggcgcgtacg ggcaggctca agggcgacac
     4381 gccggccgtc actcccgcgc caccctccga cctgctggcg gcccccggct acggcgcccg
     4441 gcggctgtac caggcctacc tcgccgcgtg gaaccgtcac gtggacccgg tactgaccgg
     4501 cccgcagttc gcggtcctgt ccgcggtccg cgcctacccc ggaagcgacc agagttcgct
     4561 ggccggcgcg gtcgccctcg acacctcgac gatggccgac ctgtgccgca ggctggagcg
     4621 gcgagggctc atccgccgcg tcgaatcccc gcacgacgcg cggcgcaaac tgctttcgct
     4681 caccgacgag ggcaagtcgg tcttgagcca ggtcaaccgc cgcgcccggc gactggacaa
     4741 ggcgctcctc gacggcgacg acgacatcga catggccgcg ctgctcaacg ccctcggcgc
     4801 gcgctgggag cggatcgccg aggtcgacaa actgcgctga ctgtcggccg ccgcttgcgt
     4861 gccgagccgt tgcctcgctg cgcccaatgt ggcattgggg acgcccaccg tctccaatgc
     4921 cacattgggc gcacaccaac gccgcatcag acgcagcgaa agcccccttc ggtccagccg
     4981 tagagcacgc cactttgccc catctttcga aattgagggg tttggccgtc cacaagggac
     5041 actttccgag ggtgaatgcc cgatttgacc gctttaagct cggggtgtga gtgatttttt
     5101 tggggggggg gcggacgggt cggccgtggg gtgaaggctc ccttcgccgc gtctgatgcg
     5161 atgaagggag ccttcacccc cggtcactca tccgcatcgc cagtccggac tcacgccgca
     5221 gagctcactt gccttacttc gagtactggt cgtagtgcag caccgcgtcg agcggaagac
     5281 gttcccgcca gccgtgccgt tccagatcgg gcaccgtcgg cagatcgcgc accgggccga
     5341 cgcacagcca cgccaccggg cgcacgtgtt cgggcaacgc caccagttcg cgcaagtact
     5401 cttcgcggta gaagctgacc cagccgacgc cgagcccttc ggcggtcgcc gccagccaga
     5461 ggttctggat ggccaggcac accgagtaca gaccggcgtc ggcgatcgcg tgccgcccca
     5521 ggacatccgg cgcaccgcgc gacgggtcgt agccgaccac gatgcccgcg gaagacgcca
     5581 cgatcccttc gatcttgatc ggcgcgaaga cacgggccct ctcggcatcc agcccgcctt
     5641 cgaacacttc gcgttcggcg agcacgtgtt cacggaactt cttgcgaagg tccatatcgg
     5701 acacgacgac gaaatcccat ggctgggaga ggccgacgct cggtgccgcg tgcgccgcgc
     5761 tcagtacgcg acgcagtacc tccgccggaa tcggctctcc ggtgaactca cccctcgtgt
     5821 cccggcggcg gaagatggtc tcgtacaacg aacggtcgtc tgcgtcacgc ttcatgagcc
     5881 cgatcgtgcc tgaccggctc ccgcggggat cgagcggtcg atctccccac cggacgtcca
     5941 cctcgtaccc acccgccgcc caccggtgcg ccgcacggtg ttgttcaggc cggtcacccc
     6001 cggcctggat cacaacatca agggagacaa cacatgtccg aatacgacat cgtccgctac
     6061 tggaaggacg agggctaccg ggccgcggtc ggcggcaaca tcctgcccgc gaacccggcc
     6121 gggatcgtcg agctcaccga cgaggcgctc gactcgctcg tcgccggtgc gggcgccgag
     6181 atggtgctgg gctcgtgcct gttcgtcagc tgcttcaacc agccgaagcc ggacgccgaa
     6241 caggcctgat cgagaaccgg cctcgggcgg cgtacgggcc ggagcatcga accccgtacg
     6301 ccgcccgagg ccgaccgact tccggggagg acgtcatggc cgagtcgatc gaccaacggg
     6361 agcagccgcc gatcttccgg gcccaggcgg tggcccacca ccggcggggc cgggacgaga
     6421 agggcgaacc acccgaactc ccggctccgg ccctgcgacg gctgtgggtc ctgctcgccg
     6481 cgttggccgc ggccctgctg accggcgccg cgacggtacc cgtcacggtg taccggcaag
     6541 gcgacgcgat cgcggtgacc ggcgtcgagg agccggtcgt ggtcgtgctg ccgatgtccg
     6601 gcgcggcaga gccggcggag aacgcggagg tcgtgctccg ggaaggcacc gtgcgcgggc
     6661 gggtggtcga gcggttcagc ggcctttccc gtgccggcct cacggcccgg ttcgggatac
     6721 cggcggccga tgacctgccg gagcccgcgg tcgcagccgt ggtgcggctc gacggcgcga
     6781 ccatccggcc cggcggccgt taccccgcct ggatcgaggt gggcaccgcc cccttgctcg
     6841 cacggctcac cgggcgaacc gatgagtgaa ccgaaacggc gccggctccg ccgccgggta
     6901 ccggtcgtcc ggcagttgac caccacggag tgcggggccg cctgcctcgc catgatgctc
     6961 ggcttcttcg gccggtccac ccgggtttcc gaatgccgcg aactgttcgg cgtgacacgg
     7021 gacgggatca ccgcgcggtc gctggtgcgg gccgcgcggg ccttcgggct gagcgtcaag
     7081 gccttctccg tcgagctcac cggattcgcc cggctcgatc tgccggtggt cgcgcactgg
     7141 tcgttcaacc atttcgtcgt ggtcgagaag cggcggagga acggctacct gatcatcgat
     7201 cccgcgagcg gcagacgtct gatcgacgac gccgagttcg cccgcgagtt caccggggtg
     7261 gcgctggcga tgacgccggg gccgtcgttc tcccggcgca gtcgtgaccg gtccgcggtt
     7321 tcggtgtacc tgcggcaggt gctgcggctg ccgggctggc ggcccctgct cgcccaggtt
     7381 ttggtggtgt cactggtcgt ccagctgctg gtcctcgcga tccccgcggt gaccaaggtg
     7441 ctcgtcgacc acgtgatccc cctgcacgtc accgatgtgc tgcaggtcgt cgtcgccggg
     7501 atcgtgctcg tggtggtgac cgacctcgtc gcgggatacc tgcgggcgtc catcctgatc
     7561 cacctgcaaa gccggttcga cacccggatc atgctcgggc tcttcggcca tctgctgagt
     7621 ctcccctacg gtttcttcgc gcagcggacc agcggcgacc tcctgctccg gttgagcagt
     7681 tcggggatga tccgggaaat gctcaccagc cagaccctgt cggtcctgct cgacggcggg
     7741 ttcgtgctgg tcttcctggc ggtgctcttc accgcgagcc ccctgttcgg ctcgctggcg
     7801 ctggcgatcg gcgccgtcca ggtgctcacg ctgctgctcg ccgcgcggcc gttgcgtgag
     7861 ctgacccagc gatatctggt cgcgcaggcc gattcgcaga gtttcggcgt ccaggtgatc
     7921 aggggtatcg gctcgctcaa ggcctccggc tccgagggcc agatcctcga ctactggtcc
     7981 tcgctcttcc tcgaagaact gcgagcctcg cttcgccgga accggctcac ggcggtcgtg
     8041 aacaccgtgc tgcacgcgtt gcggaccttc gctcccttgg tgctcctcag tgtcggggcg
     8101 gtgagcgtgc tcgacggctc gatgcgcttg ggcaccatgc tggcgttgaa cggcgtcgcc
     8161 gtcgccttcc tgtccccgct ggcgtccttg gtgacgacgg ggcaacaact ccacctggcc
     8221 ggcgtgcact tccgccggat cgtcgacgtg atcgaagcga cgcccgaacc cgacgacgcg
     8281 cccgtctcgg acacggcgtt gacgggcagg ctggagttgt ccggggtttc gttctcctac
     8341 gacccgcacg ggccacgggt gctggaagac ctgtcgttcg ccgtcgaacc ggggcagaag
     8401 gtcgcgctgg tgggccggac cggtgccagc aagagcacct tggcgatgct gatgctcggg
     8461 ctgtaccggc ccaccagtgg cgtggtccgc tacgacggac gcccgctgga ggagctcaac
     8521 ctgcggcagg tgcgcagcca gttcggggtc gtactgcagg aaccgttcct gttcaacggt
     8581 tccatcaagg cgaacatctc gctcaacgat ccggggatga gcctggaacg tgtcgtcgag
     8641 gctgcctcgc tcgccgggat ccgggacgac atcgaacgga tgccgatgcg gtacgacacg
     8701 ctgctcggcg agggtggcgg cgggctttcc ggcgggcagc ggcagcggct ggcactggcc
     8761 cgcgcgctgg ccacctcgcc ggcgttcctg ttgctggacg aggcgaccag ccatctggac
     8821 ctggcgaccg aagccctcgt cgacgccaac ctgagcgcgt tgccgtgcac gcggatcgtc
     8881 atcgcgcacc gcctcagcac ggtgcggaac gccgatctga tcctggtgct ggagcacggg
     8941 cggatcgtcg aacgcggacg gcatgaggaa ctgctggaac tcggcgggcg ctacgcggat
     9001 ctcgtccgca ctcagctcgc gcccacggct tgagcctcgg agagcaggcc gaggctccgg
     9061 actgccgctt cgccacgggc caccggggcc acgacgaact cgtcggcccc ggtcgcgtcc
     9121 gccagttccg ccagcccctc ggcagcggtg gcgggcgcgc cggcgatcag ggtcagggga
     9181 agacgacggg ccctgccgag atgcggatgc gccgcggccg cttcgggcga ccgcaacagc
     9241 aacggcggca cgcccgccag catctccagc atccggagcc ggtgcggatc ggccagccgg
     9301 tccgcctcgg cgtcggtgtc cgcgacgagc acattgaccg agacgaggac gtacggcgcg
     9361 gtcaacccgg ccgaggggac gaaggagtcg cggtacaccc gcagcggttc gaaggaacca
     9421 ccggacgtgc ggaggtggta cgcgaacgcg aacgggacac cgagttcgcc cgccagccgc
     9481 gccccccgct cccccgagcc gagcagcacg acaccgggca tgctggtcgg caccggagtc
     9541 gccgcgaagt ggtcccaaat cccttcgcgg gatcgcggat cgccgagcag gccgagcacg
     9601 tcccgcacct ggcgggggaa atcggcgtcg tccggacgtc gtaacgcggc cgccgtggcc
     9661 gggtcggtgc ccggcgcgcg gccgatgccc aggtcgatcc ggccggggtg caacgcttcg
     9721 agcatggcga actgttcggc gacgacgagc ggtgagtggt tgggcagcat cacgccaccc
     9781 gaaccgaccc tgatccgccg ggtgacggcg gcgagatggg cgatcagcac cggcggcgag
     9841 gtggccgcga cactgcgcat gttgtggtgt tcggccaccc agaaacgccg gtagccgaac
     9901 tcgtcggcgc accgcgcgag agcggtggtc tcggccagca cgccggcact ggtggactcg
     9961 gtgccgagga cggcgagatc gagtacggac aacgggatcg tcatgacggt ggctccaggg
    10021 tgaggatcga cggcacccgc gcggggtccg cggctcgcag caggccgtgg ccgatgccgg
    10081 cgagcccggt cagcaggccg ggtgtctcgg cgtgattcgg gacgccgcac agccagccgg
    10141 tggtttcgat gtccttcagc acggcggccc tccgctcccc cgccgtggcg tgcccggcgg
    10201 ctgtcagcag gtcgagggcg ccgagatcgc cgtggcacag cgaatggttc gcgcccgtgc
    10261 ccgcggcggc cgtggtgtcc gcggcctggg cgatctcgac cctggtctcg ggtccgcgca
    10321 acgcggcggg caacgccagc cgtcccaggc cgatcccgac cgcgccgtga caccacgcgg
    10381 tcatgggcgc tcgtccgccg tcctcacgca gatccggcca gttcccggaa gcggtgtcgt
    10441 acaaggcgcg ttcgtgcgcg agggcagcgg acgccgcgtc ggcgaaccgg acgtcgccgg
    10501 tcgtctcggc gacgacggcc aaggcccagc cgatcccggc ggagccgtgc gcgaagccgg
    10561 tgagcggccg gggcccgagc ggggtcaccc agcccagggt ccgccgggcg tcgtccgcct
    10621 gcgcggtcgc cagcagatgg tcgccgcagt gccgcatgat cgcgagcagc ccggggtccg
    10681 gccgatgccg atacaacccg ccgagcacac ccgccagacc ggcggagcca ccgagcacgt
    10741 ccagctggtc gtcttcgtcg atcgatccgt ccagccggaa ggccagctcg acggcttcgt
    10801 cgagcagatc cggccgtcgc cagaggacgc cgaggtgggt tagcaggtgg atcgtgccgc
    10861 cccaacccga gtacgccccg acctgccggg acggcagttc cgggcggccg agccggaacc
    10921 gcaccgacgc gagcgctcct tccgccagcc tggtgtggcg gtcttggccg gtgacgtcgc
    10981 cgagatacgc gaggaacagc gcgatcccgg agagtccgcc gtacagatcc gccccgagcg
    11041 gggtcagatc ccaataccgt tcttggaagg cggtcagccc gagccaggaa acaccgtggt
    11101 cgtgccggat cgcgagcttc tccagccggt cgccgacggc ctgggcggcc gcccggtgat
    11161 tcccggtctc cctgggacgc ggacggccgc cgtgcggtgg ccggaccggc ccggcggcgg
    11221 gatccccgac gctcagcgca ctgagcgagc ctcggatgat ccagctctgc cattcgaggt
    11281 ccgcctcgga gagcttcgcg atccgcgccc tgacccggtc gagtccggaa cgatcgagca
    11341 ggcccggaat ccgccctccc tcgctgtcgt agacgtcgcg cgacgacggc cgggtcacga
    11401 acatcgggac gtcaccgcgc cacagatccg cccgttcggc cgcgatcacc gcgcccggga
    11461 ggccggagtg ttcggcggac acccagagtt tgtcgaagaa ccgatcgcgg tccaggccgt
    11521 cccgcagcag atcgggatga gtgctttcgc gcagcagcag gctgtagaca tgggtcgggc
    11581 gcaggatcac ccggatctcg tcgacggcga accggtccag cctcccgccc gcggtcacca
    11641 acgcgccgcg ttcggcggcg agcgcgcgat agacgtcgcg gaatccgccg agcagatcct
    11701 cgacgtggtc gagcaccgag atttcggctc cacgcaacgt cgggcggttg tgcccgccgc
    11761 cgaccttcat ccgcttgcgc tcgacgtgca tctcgtcggt ccccgcggcc gcccagtacg
    11821 gcgaagcgcg aggtgtcagc tgatcttctc gattgccgag accggagatg tcgacaccgg
    11881 gtgccccgtc gtgtccccat gcgcgttgcg gcagcaggcc gacccgcagt accgagtcca
    11941 gcgccacctg cttggcggcg tcctcgggct ccgccgtgac cagccgcgaa agatccggct
    12001 ggaacagcga ttcgaggtcg accaccaccg gctgcccgcc cgcggcgatg aggttctcgt
    12061 ggtgcagatc cgtgccgccc agcgcgtaca tcagggccag ctgcccgccg aggcgccggt
    12121 agaacatcgc cacctcacgc tcgtggaggc agggcctctg ctccacgaac tcggtccagc
    12181 cgtactcgcc ccggtcgagt accgcgaagg tgggcagatc cagcccggcg accctggcgt
    12241 tcagccagtc gaccagctgg tggaaatgcc ggtcgatcgc cagcgacttc ggcttgtaga
    12301 ccagccggtg cccgccggtg aacgaggcga tgagcaccgc ccgcccgcct cggtgccgat
    12361 cgccgacgtg gccctccacg cggctcaaga gccccggctc ggccgacggg aagagcgact
    12421 ccttgagcag agaccaatcc gcggtgagcc tgcgcaggaa ttccagcagt accacggtcc
    12481 gtcgttcgac atgttcgctg aggagcctgc cgagtaccgg gtactcggtg aacagcgcgt
    12541 cgatcgtggc cggttcacgc aggtcccgga ggaacgcgcg ataacggtct gccgggctct
    12601 cgccgtccaa gtctccgcgc agccgggcga cgttgagttc gaggaccgac gtccgctcga
    12661 cgagggcggc gacaccgagt tcgacattgg tacgcaccag atgggcggcg ctgcccggat
    12721 ccaccggacc accctccgcg gacagccggg tcagctctgc cgtgacctgt actcgggcct
    12781 tgcgcagcaa cggttccgcg agcaccacga agccgcgcgg ttccgtgtcg tcgcggtgac
    12841 tctcgtcggc gtacaccccc agatccgcca gccacgacgg actcggggag cgatcgcgca
    12901 gggcggactc gtcttcgccg agcaacgctt ccagtcccgc ttcggtgatc ccgtccagtt
    12961 ccagccgacg gccgaaccag tctccccggt cgaacggccg ctgctcccgc cagcggacga
    13021 gcctgcgccg cgcctgctcg ccgccgttcc cggcgccgtc caccggcagc ctctcggcga
    13081 gggaaagcgc gcgataccaa gaggaatcgt cgagtctcac cggtcagtct ccgttcttct
    13141 cggtggttgc ggtgaccacg ctgaggccag gcggtcggca tcgggtgtgc ggccggtcgg
    13201 caccgggtgt gcggacacgg ccgggcagga cgcgcagcgc ggcgggcgac cggtcgtccg
    13261 gcagacagac ggcgtaatcg cgcagcaggt cgtgcatcgc gtaccggccg ggggcgacga
    13321 cgtcgagcat gttcgccgcg gcgagctggg agagggcgcg ccgcgccgcg cggagtccga
    13381 gcccggcgat cgcgacggtc ttcccgacgt cgagctccgt cccggctcgc ccggccgccc
    13441 ggaacacccg ggccgcgtcg aacggaagcc gtcggtagga ccaggaaaga ccttcgcgca
    13501 ccgacgcgta cggatcaccc gccacctcaa gcaattcgag ccggtcctcc ggttcggcga
    13561 gggcgtcgac gagttcgcgc agcgcggtgt ccggctcggc ggtggcgact tccgcggcga
    13621 tccggagcgc cagcggaagc cgggcgcaca gttcggccaa cgcggacacc gaacgcggat
    13681 ccgcgtcggc ccggtcgccg atcagggcgc gcaggagtgc gatcgcgtcg gcgagcggca
    13741 gacggccgac gccgacgcgg cgcgcaccgt gcagggcgac caggccggcc agcgagtccc
    13801 tgctcgtcgt caccaccgtg cacgacgggg tgcccggcag caacggccgg acctgcccgg
    13861 cccaacccgc gttgtccagc acgaggagga gacgacggcc ggcgacctcg gtacggaagc
    13921 gggcggcctg gtcgtcgagt ccgacgggga tctcccgttc gctcaacccc agtgcgccga
    13981 ggaacccgga caacgcggct cccggcggca ccgggcggcc ggggccgtgg ccgccgaggt
    14041 ccacgtacag ctgcccgtcc ggaaagcgtt cccgggcgag gtgggcccag cggagggcca
    14101 acgcggtctt gccgacgccg gcggtccccg aaaccacggc cgtccccgcg gcggcggtga
    14161 cccggccgag ttcggagagt tcggcttcgc gcccctggaa atcgcggatc tcggcgggca
    14221 gctgagcggg taccggcgcg cgggtgatcg ccggaggatc ctttttcggt gccggtgccg
    14281 gagccggtcc ggcgaggacg agacgatgtg cccgccgaag actcgagctc ggttcgacac
    14341 cgagctccgt caccagcgca cgccggatcc gttggtacac cgcgagagcg tcggcctgcc
    14401 ggtcgcagcc gtgcagtgcc agcatcagct gcgcccacaa ccgttcccgc aaaggatgtc
    14461 tgcgcaccaa gggttgcagc tcggtgacga gttccggggt ggcacccctc cgcagttcgg
    14521 cgtcgacccg gtcttcgaac agggcgagcc gtagttcctc gaggcgggcc gcctccgcac
    14581 ggcaggtctc cccttcgagg ccgtcgagag ccggcccgcg ccagcaggac aacgcctcgc
    14641 gcaacagggc cgccgcccgg ctcgcgtccg ttttcgcgat caccgccagc tcctcgaccc
    14701 ggtccagatc gcgttcaccg gggcggacct gcagcaggta tcccggcgcc ctggtcaaca
    14761 gccgctcgtc gcgcccgacc cccagtgtcc ggcgcagcat ggcgacgcag cccttcaaca
    14821 gaccgcgggc ggacgagggc gcaccggcgc cccacagctc gtcgatcaac cggtcggccg
    14881 acacgaccga gttggcgttg agcaggagga gcgcgagcaa ggtccgctgc tgtggtcccc
    14941 cgaggggcag ccgcgcgccg tcgtcccaga cctccaatgg ccccagaatc ctgaatatca
    15001 tcccgttctc agctcgttcc ccgtgtcccc cgccgggtta cccgccaacc ggataccggc
    15061 tctttccgtt cctttccctt gcgataaaag gaattcttac cggccgacta ttggaaaatg
    15121 ttgtgattgt gttgtggcga ccgaaatacc ggctctacca ttcttccggg cgggaggatt
    15181 gtgaggggat cacgtggatt tccggttact ggggccggtc cggctgcagg tgcgcgggca
    15241 gaacgtcgcc atcggcgagc cgcgcaggca ggccgtgctc gccgtgctgt tgctcgaagc
    15301 gggccgaacc gtcggcgtcg atctgctgat agaccgggtc tggggagagt caccgcccgg
    15361 acaggtgcgc cgttccctgc aggcgcacat cacgcggatc cggcgcgcgc tggaacaggc
    15421 cgatcccggt ggcgcgcggg tggccaggga tcccggtggc taccgcctcg tcgcccggcc
    15481 cgaacaggtc gacgtcttcc ggttccggcg cctgctccgc gagcacccga ccgacgtcag
    15541 caggctgagc gcggcactcg aactctggga gggtgaacca ctggccgggc tgcgcggcga
    15601 ttgggccgaa cgcacccgcc gcacgctccg tcaggagtac acggcggcga tcgtcgcgtg
    15661 ggccgacgcc aagatccgtg acggcgacgc ggcggcgacg ctcacccgcc tgaccgaact
    15721 caccgacgag aatccgttgc aggagcccgc cgcggcggcg ttgatgcggg cgctgtacgc
    15781 cgtgggccgc ggcgccgacg cgctcaccca ctacgaacgg attcttcgcg cactgcgtga
    15841 agaactgggc gcggatcccg ggccggaact cgccgccgtg cacgaggccg tactccgcca
    15901 tgacctgccg acggcgagcg cggcgcctgc tcccgtgccc gcccagctgc ccgccgacgt
    15961 cgcggcgttc accggccggg ccgacgtgct ggccgagctg gaccggttcc tcgccgacgg
    16021 caccggcgaa gaaccggtcc tcgtctgcct caccggtacg gccggggcgg gcaagaccgc
    16081 gaccgccgtg cactggggcc accgggtccg ggaccgcttt cctgacggac agctgtacct
    16141 ggatctgtgc ggctacgccc ccggcgagcc gatgccctcg tccgacgcgc tggccgccct
    16201 cctgtccgcg ctgctgcccg aaggcacgcg gatgccgcca gggcaggcgg aacgcgccgc
    16261 ccggttccgc accgaggtgg cgagcaggcg gatgctcgtc ctgctggaca acgcggcgac
    16321 gctcgaacag atccggcccc tgctccccgg cacgcacacc tgcgccgtgg tggtcaccag
    16381 ccgcgactca ctcgccgggc tggtcgcgct ccacggcgcc caccgggtcg acgtcgaccg
    16441 gttgtccgaa gccgacgcgg ccgacctgct ccggcggctg atcggcaccc gggtcgacac
    16501 cgaacccgag gccaccgccg aactggccga acgatgtgtc cggctgccgc tcaccctgcg
    16561 cctggcggcc gaactcgccg tgtcccggcc cgccaccccg ctgtcccggc tggtcggcga
    16621 actgcgggcc gcccagcaga cgttgaagct gctcagttcc ggcggtgatc agcgggccgc
    16681 ggtgcgggcg gtgttctcgt ggtcgctgcg acagctcagc gaagacacga tccgcgcctt
    16741 cgccctcctc ggcaggcatc cggcgcctgt gttcgactcg tacgccctgg ccgcgttgac
    16801 cggccactcc ttcgacgagg cccgggccgt gctggacgcc ctcgtccgcg cgcatctggt
    16861 ccaccccacc ggtgacgacc gctacggcat gcacgacctg ctgaaggcgt acgccgcgga
    16921 gatcgagagc gacgagcccg cggcgctgga ccgggtctac ggctactacc tcgccaccat
    16981 cgcggcggcg atggatcgcc tctaccccgc cgaagcgaac cgacggccct cggtcgcctc
    17041 gccggagtgc gcgatgcccg cgctcgacga cgccgacagc gcccgggact ggctggacgc
    17101 cgaactgccg accgtccagg cgctggccac ggccgggaga cccgaacacg ccgtgacact
    17161 gtccgcgctg ctgttccgct acctcgacgg acatcacgag acggcggcgc tggccgtcca
    17221 cgggcacgcc atcaaggccg cccgcgccat cggtgaccgc gccgccgaag cggacgcgct
    17281 ggtcgccgcc ggcggcctcc acatgcaagc gggcagagcc gtgtcggccg ccgcggacat
    17341 gtgggcggcg tacgccttgt tcggcgaggc cgggaatccg ctcggccagg cacgcgcact
    17401 gggaaacgtc ggaatgatcg aggaaagcgc cggatactac cggcaggccg ccgattacta
    17461 cacccgcgcg ctggccctgt tccaccgtct cggcgacctg accggtcagg ctcatcagct
    17521 cacccggctg ggcaccgtcg aagcccggat cgaccgccgg gaagagggat acgagcacct
    17581 tcggcaggcg atggccctgc atcaggaggc gggccaccgt ttcggcgagg cctgggtgaa
    17641 gatcggcctg ggggaactcg ccgcgaacga aggcgggctc gccgattcct gccgcctgca
    17701 cgccgaagcc gcggccttgt tcggcaggct cggccatcgg ggcagcgagg cgtgggccat
    17761 cgacgggctc ggacgggccg aagcgctgga cggccgtccg gtcgacgcgg ccgcccacca
    17821 ccgtcaggcg ctcgacctgt tccggcggca cggtggccgc gacggcgaat cctgggcact
    17881 caacggactc ggcgaagcct gtctggcctg cggctacccg gacacggccg gcgcgaacca
    17941 cgccgaggcc ctggacgtgg cgacgcggta cggctgccac gagcaggtcg cgcgcgccca
    18001 ccgggggctc gcgcgggtcg cctcggatcc ggaaaccgtc cgcgaccact acgaacgcgc
    18061 gatcgcccgg tacgccgagc tgggccttcc cgccgcggag tgcaccagga cggaactcgc
    18121 ggagctttcc ttgtcctgtt gaagggtggg cacgaagtca aacgtgccgc cttcgtgggc
    18181 taaagggtcc cttcgccgca tctgatgcga cgaagggagc cttcagcccg gtcgaaaccg
    18241 ctcccggccg acgatcaggg gacttcgtag aacttgtcgt agtggcccgg cgcgtaatag
    18301 aacttgccct tgtcgtccat gacgatgcga tccggcttcg gccgctggtt ctccggcaac
    18361 ggtttcccgt tgaagtccgt gtactggtcg gcgtcccgga tgggtttgtt gtcgtaccgc
    18421 ggcgtcgggt ggacgtcgaa ttcgtagtac ttgccgtcgt acggtttcgt cggcttcccg
    18481 tccgggccga acggctgatc ggcgtggttc ttgccgtcgc tcgtcttgcc gttgtgcggc
    18541 aaccggccct cgttcccgag cttgccgccc gcctggccgt ggttcccgta gatcctgccg
    18601 ccccaggtcg aaccgggacc gggggtcggc ttgttcccca agcccagcga gttgagcttg
    18661 ttgtcgtcca cgccgttgtg ccaggcgccg aactggccgc tgtccttgtg gtcgcggatc
    18721 cactgtttca tcttgatcgc cgcgtccttc tgcgcctggg tcagctcgtc gaacttcccg
    18781 aggttcgggg aaagcccggg cggctgctcg ggttgcggtt tggaattctt ccccttgcca
    18841 ccgcccccgc cgcgcgttcc gctgtagtcg ccgccgcccg gtttcgggcc gcggggtttc
    18901 cccgccgggc cggtcttgcc cgtgtcgatc ttgcggagtg ccttctccgc ctcggcgaag
    18961 atgttcttcg ccttcttcat caacggcgcg agcgcgctca tcgccttgac cagtttggtg
    19021 acgacggtgg cgatcttgga ggcggtcttc gcgatcgcgg cggtgacctg gggcagcacc
    19081 caggtcatcc cgaggccgag cgtcgccagc acctgcaggg cccagctgat cagcctgccg
    19141 atcagttcgg cgatggtgtc acggaccagg gtgcggaccg cggtgaccac ctccccgccg
    19201 atcttggtgc cggacgccgc gccgcctgcg gcctgctggc aggcgccgat cagcgccgcg
    19261 acgtccgctc cccgcgtgcg ataggcgtcg cccgcggcac cggcccagtt cgcggtttcg
    19321 gcgacgacca tcgcgtccag gtcggcactg atcgagccga gttcgacggc cacgttctgc
    19381 caggtttcgg cgtgcgcggc gatctcgtcc ggtgctccgg cgagggcgtc gagcgcctcc
    19441 ttcagcggtc cgacgtgctc catcagccag ccgaccccgg cggcgaggat ggtgccgaac
    19501 ggatcgaggg cggcggacac ggcgtccatg gcggtgccga ccgcgccgac ggcgacggac
    19561 gcccagtcac cgctttcgat ggacgccttg agctcggtcg cggattcgag caagggaacg
    19621 ccggacaccg cggtggtgga atccttcggt gtggcgacga gcgggttggt catcgctgcg
    19681 ccttctcctt cggcgtcgcc gggatcgcgg cctcgtactg cttgaacatc tcgacaccgg
    19741 cggtgtcctg ctcggtgtag gaccgttcgg ccgtgcgcag gttcgcggcg gtcgccttca
    19801 cgccgtcgat cgcggccttg atcgagtcga tcgtcttctc ctccgccgga ttgatgaacg
    19861 gcgggacgaa cgcgcagatc agaccgtagg cctcgtccga catggccgcg gtgttcgccg
    19921 ccgacagcac ggtgcccaac cgctcggcga tcccgtcgac agtggccgcg tgcttgccga
    19981 tttcggccgg tacgacctga aaactcatct gccatccctt cgaggggccg gagcgtcaac
    20041 gcggacacga tgccagccgc ccgccgcccg tgtccgcgct ctgtgcggac agacaacgtt
    20101 ccttgcccta aagggcacga tccactgtgg acacacgttg tccgtcggcg aggaacggcg
    20161 tcagcaggcg gagcaattcg ccaggcttgt ccagcgggat gatgtggccg cagtccggca
    20221 gcagatgggc ggtgaggtcg tcggtgacgg gacgcagttg ccgttccagc gcacggccga
    20281 cgggatgcgc gccgatcgcc atcgtgggca cggcgagacg gcgcgtcgcg accgcctcac
    20341 cgatctggcg cgcgctgacc ggcatggcgc gatagtggga aaaggcgcag cgcagggctt
    20401 ccccaccggt gtaggcgtcg acgaaggcgt cgcggatctc cggcgccaca ccacgcccga
    20461 gggtgcccga ggcgagaaac cagtcgatgt actccgcctc gtgtccgata aggacggttt
    20521 cgcccagccc gggaacggcg tggaagccga accaccacgg cgggccaccg gcgaggaagt
    20581 cctcggcgcc gggcagcgag cccaacagcg actccatcag gacgagccgc cgcaccagct
    20641 ccggccgccg cagggcgagc aggaaggcga ccggcgtgcc ggcgtcgatg gcgaccaccg
    20701 ccgcgctggg ttcgccgagc gcgtcgagaa ggctctcgat gtccgaggcc agcgtgctcg
    20761 cgtcgtagcc ttcggcggct cgggtgctgt cgccgaaccc gcgcagatcc ggggcgatga
    20821 cccggtggtg ctcggagagc gggccgatga tctcgctcca gagccgccag gtgtgcggga
    20881 agccgtgcag caggagaacc gcgggcccgc tgcccgcgac ggccacgttg acccggatgc
    20941 cgttgacggt gatccgccgt gatgagggca cgtcgcctcc gatgtggtta ccattggtta
    21001 ccagaaaacc gtaggtaact tcggcgatgc cgccaagacg gcactttcga cacaggtggt
    21061 gagctccagg tgaccccacg gcgcggtgat ctcttcgacc ccgaatgccc cactcgccgt
    21121 ctgctggacc gcatcgggac gaaatggacg tcgatggcgg tcaaggtcct cgcggaggcg
    21181 gctccgcacg aggtgcggtt cgccgagctg cggcgccgga tccccggggt gtcccagaag
    21241 atgctgtcgg tgaccttgca cagcctggtc cgcgacggcc tcgtcgtccg ccgggtggag
    21301 cccaccgtgc cgccccgggt gcactacggg ctgaccgacc tcggtttgtc actggacgtc
    21361 ccgctggcgg cgctccggga ctgggccgaa gagcacatgt cacggatcga cgaggcgaac
    21421 gcggtcagcg acgccgcgag gaagagttcc gccaccggaa tggagtaacg tgctccggtg
    21481 cgacgtgcgc gaagggagac gacactgtct cgggaaacgg ctcggatctg gttgcccgag
    21541 cggcgccgaa gcggcttgag cctcgcgttc gcgctgctcg tcgccgcgct ggcgatcgcg
    21601 ttcggcgacg acgtgctctc actcgcctcg gtggacggcg gcgtcctggt tcttctcgcc
    21661 tacctcatcg gctatctcgt cgtgacggtg gccgcgttcg gcgcggcgac ctcggagcag
    21721 atccaggact gggcgtgccg ggagagccgc ggcacgttcg tgcagcgcta cgtcttcggg
    21781 acggcgccag ggccgggagt gtcgatcttc atcgccgcgg ccgcgctcgc ggtggcggtc
    21841 gtgtggatgc ccggtctggg cggcgagagc ctgcccgcgg gcatgcgcgt gggagtggcg
    21901 gtggccctgg tcgtcgtcgc gtggatctgt gtgctcgtgt ccttcgctat cgcctaccac
    21961 gcggacaacg tggtcgaaga gggcaaggcg atgcggttcc ccgacgacgg aatcgccgag
    22021 tggtccgact acatctactt cgcggtgtcc gtgatgacga cgttcggcac gaccgacgtg
    22081 gacgtcgtct cccgcgagat gcgcaggacg gtgacgacgc acgcgatcat cgccttcgtg
    22141 ttcaacaccg tcaccgtggc ggcggtcgta tccgccttga acagcggctg aaatccgggc
    22201 tcagccgagc cggagcagga tcgggctgcc ggtgacggtg acatcggcac cgggctcgac
    22261 cggcgtcccg gtcccgtcga gcccttcgac cgatgtggtg cccggcgccg acgggatccg
    22321 ttcggaacgg tcgatggtcc accagatcag gaagttccgg ccgccctggt cgaagcggca
    22381 ttgccaaaga tggtcgggca gcccggcttc gcgcccttgc ccgcaggaat ggattcggct
    22441 gcccttcaac cactcgttca ggcgttccac gtgtcgcgcc gccttcgtat gcggaccgcc
    22501 gacgggttgc agcacgatcg ggatcttcgc gctgccccag ttgtagaagt acatccggcg
    22561 gtattgcgcg tacagcccgg agaggaagaa ccgggccgcg tgctgcgctc cccgatcggc
    22621 gtccacgggt tgctgcctgt tcacgtcgta ggccgaaccg gtgctccaca gccggacgcc
    22681 ggcgccggcc tcctgcagtg ccttctcgat ctcccgagcc aacggcagca tcgtctccgg
    22741 cgggtcggag tcgttgcggg gagccagttt caccgcggcg gcggcgcaat ggtcgtagcc
    22801 gccgagccgg gcgaactgtc gcagcttctc gaacgccgaa ggatcccaga gctcgcccat
    22861 ggacgggcac accacggtgg cagccgggtc ggcggacttg atcgcccggc tcgccagccg
    22921 cgtcatctcc accaattcgg gcatcgaacc ggagaagaag tcctgatgat tggccagatc
    22981 ccacagttcg taggcgtcga tccggccccg gtactgctcg gcgacggcac gcacgaaccg
    23041 ttcccagtcc gcgaggtcgt cgggcgggcc ggtgcgggag tcgtcggtgt agacggactt
    23101 cgggctgttc gggctcgccc
//
