LOCUS       NZ_LIWC01000001        22092 bp    DNA     linear   CON 28-MAR-2024
DEFINITION  Amycolatopsis sp. CB00013 scaffold1, whole genome shotgun sequence.
ACCESSION   NZ_LIWC01000001
VERSION     NZ_LIWC01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Amycolatopsis sp. CB00013
  ORGANISM  Amycolatopsis sp. CB00013
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 2203332)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2203332)
  AUTHORS   Yan,X., Ge,H., Hindra,F., Yang,D., Huang,T., Crnovcic,I. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-AUG-2015) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2014
            Assembly Method                   :: CLC Genomics Workbench v. 7.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905755.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:05:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,488
            CDSs (total)                      :: 8,430
            Genes (coding)                    :: 8,383
            CDSs (with protein)               :: 8,383
            Genes (RNA)                       :: 58
            rRNAs                             :: 1, 3, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (5S, 23S)
            partial rRNAs                     :: 3 (16S)
            tRNAs                             :: 50
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 47
            CDSs (without protein)            :: 47
            Pseudo Genes (ambiguous residues) :: 0 of 47
            Pseudo Genes (frameshifted)       :: 17 of 47
            Pseudo Genes (incomplete)         :: 38 of 47
            Pseudo Genes (internal stop)      :: 1 of 47
            Pseudo Genes (multiple problems)  :: 9 of 47
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:01:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1771123
            Orig. end                         :: 1793215
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LIWC01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22092
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="12"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22092
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22092
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12092](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12092)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     gene            complement(1010..1558)
                     /locus_tag="AMK34_RS07940"
                     /old_locus_tag="AMK34_07890"
     CDS             complement(1010..1558)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009154009.1"
                     /locus_tag="AMK34_RS07940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_07890"
                     /product="manganese efflux pump"
                     /protein_id="WP_073843990.1"
                     /transl_table=11
                     /translation="MSLEFLPLLALAFGLSLDNFRSSIAIGTIPFGWRRALQVALVFGI
                     WDAVGPLLGGFLGSYLGDFLGDWAEYIGAAALGLYGVYFIVGAIRHPEPQDMDHPWVTL
                     FGMPLSLTVDNFIAGAGLGIAGFSLVVPMLTFGAMTVVMSFAGLYVGRMAARVVRIRAD
                     LFSGISLLSAAILLPLVFG"
     gene            2419..2889
                     /locus_tag="AMK34_RS07945"
                     /old_locus_tag="AMK34_07895"
     CDS             2419..2889
                     /EC_number="5.3.1.6"
                     /GO_function="GO:0016853 - isomerase activity [Evidence
                     IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010242309.1"
                     /locus_tag="AMK34_RS07945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_07895"
                     /product="ribose-5-phosphate isomerase"
                     /protein_id="WP_073843991.1"
                     /transl_table=11
                     /translation="MRIYLGSDHAGLELKNHFVARLSALGHETIDVGPSVYDANDDYPP
                     FCVEAARRVVADEGSLGVVIGGSGNGEQIAANKVPGARAALTWSVDTAKLARQHNNALL
                     AGIGARMHTVEEAEHIVDAFLGTEFEGGRHQRRIDLLSEYERTGEAPALPGH"
     gene            complement(2995..4020)
                     /locus_tag="AMK34_RS07950"
                     /old_locus_tag="AMK34_07900"
     CDS             complement(2995..4020)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009154007.1"
                     /locus_tag="AMK34_RS07950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_07900"
                     /product="HAD-IIA family hydrolase"
                     /protein_id="WP_073843993.1"
                     /sec_met_domain="HAD_2 (E-value: 7e-05, bitscore: 19.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAEKTGNDALITRYRGLICDLDGVVYRGPSAVPHAVETLNRVTA
                     RGTPVVFATNNASRPPEEVSEHLRGLGVAPRGWSVVTSSQAAAAHLAERLGRGTPVFAV
                     GGPGVARALTEAGLTPVRVADLDGTPVEAVVQGLGTDVTWRELAAVGRLADAGATWVAT
                     NVDLTLPTPYGRAPGNGALVALVRTATSASPHVVGKPRAALFDLARHRLGTVHSETLVC
                     GDLLDTDIEGANSAGLDSLLVLSGASRLRDLACAEPSARPTYVAADLSGLLAPGRPLRA
                     VSSDLTPDAMSRMPNAVGDDELLRSVVTTAWAVHDAGRAVSDDDGLWEKIEQQLGLGHS
                     V"
     gene            complement(4017..4994)
                     /locus_tag="AMK34_RS07955"
                     /old_locus_tag="AMK34_07905"
     CDS             complement(4017..4994)
                     /EC_number="3.1.3.11"
                     /GO_function="GO:0042132 - fructose 1,6-bisphosphate
                     1-phosphatase activity [Evidence IEA]"
                     /GO_process="GO:0006071 - glycerol metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006094 - gluconeogenesis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020661093.1"
                     /locus_tag="AMK34_RS07955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_07905"
                     /product="fructose-bisphosphatase class II"
                     /protein_id="WP_083649777.1"
                     /transl_table=11
                     /translation="MNTQEWDIPGRPGMAAGGSGQALALELVRVTEAAAIAAGEWVGFG
                     DGNSGEAAAHVMRELLGSVRMRGVVVAGADGKGATPVLFAGDDVGSGDGPACDVAITAG
                     DGALSPVKDVPYSLSAIAVAERGALFDPSPGASMEKLAVGPECVDVVDIRRPVAENLRA
                     VAKAKDIRVSDVVVAVLNRPYHRDLVHEIRDAGARIHLLEGGEVSGAIAVARPESPVDI
                     LLGAGGAAEGVIAAAALTCSGGALQARLQEGKVLHTEDLVGGENILFCATGLTGSELLR
                     GVQHHSGRVFTQSLVMSSKPETVRMVRSERPHVARREQEGRRTA"
     gene            complement(5099..6076)
                     /locus_tag="AMK34_RS07960"
                     /old_locus_tag="AMK34_07910"
     CDS             complement(5099..6076)
                     /EC_number="4.1.2.13"
                     /GO_function="GO:0004332 - fructose-bisphosphate aldolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010228265.1"
                     /locus_tag="AMK34_RS07960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_07910"
                     /product="class I fructose-bisphosphate aldolase"
                     /protein_id="WP_073843997.1"
                     /transl_table=11
                     /translation="MSALNKIARTMVSDRRGILAADESIGTMSARLEKVGVEATAENRR
                     IYRELIVTTPRLSESVSGIILADETFHQKVSDGRTFPEFLEDIGILTGIKVDTGAKPLA
                     GSPEEKITEGLDGLRERVTEYVRLGATFAKWRAVITIGEDEPSARAVRANVHALARYAG
                     LCQEAGLVPIVEPEVLMDGDHTLERCRQVTTAVLESLFEELDLMRVRLDGIVLKPNMVV
                     AGTGSPERPTVADVARATVETLRETVPSSVPGIAFLSGGQSPEVATQHLGAMQELDPLP
                     WELTYSFGRALVGPALEAWRGDEGNRVAAQNALSERAVANAAAR"
     gene            complement(6138..7181)
                     /locus_tag="AMK34_RS07965"
                     /old_locus_tag="AMK34_07915"
     CDS             complement(6138..7181)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009154004.1"
                     /locus_tag="AMK34_RS07965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_07915"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_073844674.1"
                     /transl_table=11
                     /translation="MVLPSKMPQLADLDLLLSVESHGSVGKAAQAHSLSQPAASIRISA
                     MERRLGLKLLERSPAGSKLTEDGEMLAKYARNVMQAARELLEFGSGARSSDAKRLRIAG
                     SPAVSEHLIPEWLNRSGFSFGEARVEVRTGSVETLHRLIRASHVDLAFIDGWCHAGGQG
                     REQSREDLMTRYICDDKLAVVVGSRHPWAARRSPLTVQELAAAPLVLRERGSGLREFTD
                     ELLGTSRVPRGYVEFPSSAAIKQTVATSKRVTVLNVSTVRSELAEGRLHLVTVDQEMPA
                     KPIYAAWSERRGLPDHAKELLEIAVSKGSPMPPVVVPGQQPRTVDWRKRKHSREPSLAG
                     EGHGSMT"
     misc_feature    complement(6279..6281)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    7394..7409
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.13"
                     /tool="antismash"
     gene            complement(7477..9996)
                     /gene="pepN"
                     /locus_tag="AMK34_RS07970"
                     /old_locus_tag="AMK34_07920"
     CDS             complement(7477..9996)
                     /EC_number="3.4.11.2"
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008237 - metallopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene="pepN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009154003.1"
                     /locus_tag="AMK34_RS07970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_07920"
                     /product="aminopeptidase N"
                     /protein_id="WP_073843999.1"
                     /transl_table=11
                     /translation="MSAGSRAGRPLTRDEATARSAAIFGVQYTVDLDVTLGERTFATTT
                     VVRFQARTGIGFVFLDFAGEVESVECNGRALGPDAQNGTRVRLEVRPGANTVRVAGTAP
                     YSRTGEGLHRFRDPLDGHVYLHTKFQPFAAHKVFACFDQPDLKAPVEVTVTASDQAVVV
                     ANTDPVESRTAGGRTAWRFEPTPPLPPYLVAFAVGSFRRLGSHHRGVPLALYARDSLFE
                     ELVEDAPELFDVIGRGLDFYRGSFALPYPFTKYDHVFAPEYAFGGMEHPGCVTLNERFL
                     FRHRVTDDERRRRAEVLLHEMAHMWFGDYVTLRWWDDLWLNEAFAELMSIIAQRDATRY
                     GEGWTAYAHHSLPVARHADRLPTGHAIRVETVDTDAARVNFGPIVYKRGAAVLRDLAGR
                     LGWETFFAGVRTYLRAHAWGNASLDDFVAALRQSSDEDLGRWVDEWLLRRGVNTVEVSR
                     LAAGDRLVQLPDPEVLPRHLNLRVAAFEDHDGKLVPRRRVPVVLTPGRSEEDLTAFGGP
                     DLLVPNDDAVCHVKVRLDPRSRRTALRALSTLDDRRARAVVWGALWDDVLDARLPARSY
                     ASAVLTHGVHEDDDGVLKALLERAVQAVRVYGAPADRRQALEGLARRIHEQLAAAAPGG
                     DRQLVFARVLVGVVRAEGHGLLQEIVCGRSPWAGLEVDRDLRWRSLFRLAAIGRDVGGL
                     LDVAREADPGDSGHRNALMVEAARPTVAAKDEAWARSTGDDLSLAEKKAVMAGLREPGQ
                     EALLTRYTDHYWRSLKDLAATGRPEFVLAFARALYPRFTEDELSVLADTDEVMESGLLS
                     DDVLKVVREERAELLLIRAARACDAAL"
     misc_feature    complement(8368..8370)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(10001..11125)
                     /gene="pqqE"
                     /locus_tag="AMK34_RS07975"
                     /old_locus_tag="AMK34_07925"
     CDS             complement(10001..11125)
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010228268.1"
                     /locus_tag="AMK34_RS07975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_07925"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_073844001.1"
                     /sec_met_domain="PF04055 (E-value: 3.6e-19, bitscore: 66.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 3.2e-07, bitscore: 27.6,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 5.7e-09, bitscore: 33.2,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.2e-10, bitscore:
                     38.5, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNGTPQPYGLLAEVTHRCPLHCVYCSNPLELREREDELGTDEWVR
                     VIGEAAGLGVVQVHFSGGEPLVRGDLETLVAECRRLGLYTNLITSGLGLTEARAESLVA
                     AGLNSAQLSIQGDAAESTDLVAASKRFDKKEAAAGIIRDAGLPLNMNVVLHRLNLHRLD
                     AIIDVCVKWGAERLELANSQYYGWALRNRESLMPSKSQLDEAVGVYERRKAELAERMEM
                     LWILPDYYEPYPKPCMGGWAQTALTVAPDGVVYPCPVAAEIKTMEFSSVRDHDLEWIWT
                     KSAAFEAYRGTEWMPDPCRGCPRKELDFGGCRCQAFALTGDAGRTDPVCQHSPDHHLVQ
                     SALVRANQEDVAADGEVIRERLVYRRPTVSARRR"
     gene            complement(11122..11397)
                     /gene="pqqD"
                     /locus_tag="AMK34_RS07980"
                     /old_locus_tag="AMK34_07930"
     CDS             complement(11122..11397)
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017983457.1"
                     /locus_tag="AMK34_RS07980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_07930"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_073844003.1"
                     /sec_met_domain="PqqD_RRE (E-value: 1.5e-20, bitscore:
                     69.7, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.9e-13, bitscore: 47.4,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDDGDLAATPRLATKAMLKHDSVRDVELLLLPERVVLLNKSGAAI
                     LGLCDGSRTVRQVVERLEQEFEATDLVNDVMTFLRDASGRGWVVVT"
     aSDomain        complement(11134..11376)
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_AMK34_RS07980_PqqD_RRE.1"
                     /evalue="2.10E-22"
                     /identifier="RREFam006.1"
                     /label="AMK34_RS07980"
                     /locus_tag="AMK34_RS07980"
                     /protein_end="88"
                     /protein_start="7"
                     /score="69.7"
                     /tool="antismash"
                     /translation="ATPRLATKAMLKHDSVRDVELLLLPERVVLLNKSGAAILGLCDGS
                     RTVRQVVERLEQEFEATDLVNDVMTFLRDASGRGWV"
     gene            complement(11397..12092)
                     /gene="pqqC"
                     /locus_tag="AMK34_RS07985"
                     /old_locus_tag="AMK34_07935"
     CDS             complement(11397..12092)
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017983458.1"
                     /locus_tag="AMK34_RS07985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_07935"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_073844005.1"
                     /sec_met_domain="TIGR02111 (E-value: 1.1e-93, bitscore:
                     309.8, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPWSAEEFEARLRSIGEKRYHHLHPFNERMHSGTLTEEEFRGWV
                     RNRFYYQLNLPVKDAFILTKLPGRADRRRWIQRIIDHDGREGTEGGLEKWVRLGEAVGL
                     TREELFDVDTVLPGVRFAVDAYVDFCRQKPWLESVASALTELFAPDLLSRRITDVRRHY
                     PWIAEEGLEYFRARLTQQPKDIAHLLELVLEHAKSRAQQDACARALEFKCDVLWSLLDA
                     VQFAYGKGS"
     gene            complement(12089..12997)
                     /gene="pqqB"
                     /locus_tag="AMK34_RS07990"
                     /old_locus_tag="AMK34_07940"
     CDS             complement(12089..12997)
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020661100.1"
                     /locus_tag="AMK34_RS07990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_07940"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_073844006.1"
                     /transl_table=11
                     /translation="MFVHCLGVAAGGGFPQWNCACAGCRTARAKPEVATMHAGLAVSGD
                     GERWFLLNATPDVHHQIAADPALHPGPGIRATPVAGVLLTDAEFDHTIGLLMLREESSL
                     KVYGTRPVLEALSSWFPVRELLSDYADLSWSLLEIGKPLDLDDRLRATAFLTGSKAPRY
                     VGKSRHAPQRGSSEWEVGFRLQDKVTGGTVVYAPTLPRWDAKFAEQVASADCVFLDGTF
                     WTDDEMSCQGAGSRTGRSMGHMPVGGADGSARALAALPAKRKIYTHINNTNPILDEGSG
                     ERRWLTSLGIEIGRAGLEVEV"
     gene            13322..13951
                     /gene="hxlA"
                     /locus_tag="AMK34_RS07995"
                     /old_locus_tag="AMK34_07945"
     CDS             13322..13951
                     /EC_number="4.1.2.43"
                     /GO_function="GO:0043801 - hexulose-6-phosphate synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019647 - formaldehyde assimilation via
                     ribulose monophosphate cycle [Evidence IEA]"
                     /codon_start=1
                     /gene="hxlA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020661081.1"
                     /locus_tag="AMK34_RS07995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_07945"
                     /product="3-hexulose-6-phosphate synthase"
                     /protein_id="WP_073844008.1"
                     /transl_table=11
                     /translation="MELQVALDVLDLPSALTLANQVAGHVDILELGTPLVKSAGIGAVS
                     AIKAAFPDKLVFVDLKTADAGELEATLAFEAGADLVTVMGAADDDTVRGAVAAGKKYGK
                     QVVADMITVVDGRVSRIREVAKLGVSFVEIHAGLDEQARPGYTIEQLLRDGREAGVPFS
                     IAGGIKIDTIASVREAGAKVAVAGGAIYNATDPATAAKELKQRATR"
     gene            13964..14236
                     /locus_tag="AMK34_RS08000"
                     /old_locus_tag="AMK34_07950"
     CDS             13964..14236
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009153998.1"
                     /locus_tag="AMK34_RS08000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_07950"
                     /product="hypothetical protein"
                     /protein_id="WP_073844010.1"
                     /transl_table=11
                     /translation="MEGQKTNARHDTYCSLMLQAAGVLRLRYAECSQDTTLSPAAANQL
                     ADVFESVAHGDPAYDQIDPKEAIALAHRLLDDDHPELSRMWPRTR"
     gene            14320..14934
                     /locus_tag="AMK34_RS08005"
                     /old_locus_tag="AMK34_07955"
     CDS             14320..14934
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020661103.1"
                     /locus_tag="AMK34_RS08005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_07955"
                     /product="GPR1/FUN34/YaaH family transporter"
                     /protein_id="WP_073844676.1"
                     /transl_table=11
                     /translation="MTTAVATEAPARSAPTGDPALIGVPTFIVGATALGLVLTGYVPAA
                     AVGASIAIILPATGIGQLVAAVWAAALGENAVAAVFGIFAGFWLSYAALVLGLIHGWFG
                     ITPDAAVATQGLFLIAWLVTIVLLTLTTLRLPAAFTVLFVLVDIALALVLYGTVGGSTA
                     ATTAGGYAVFAFTAVGVYLFAGAVSTATGGKPLPLGRPVLT"
     gene            complement(15012..16250)
                     /locus_tag="AMK34_RS08010"
                     /old_locus_tag="AMK34_07960"
     CDS             complement(15012..16250)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024491.4"
                     /locus_tag="AMK34_RS08010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_07960"
                     /product="phospholipase D-like domain-containing protein"
                     /protein_id="WP_073844012.1"
                     /transl_table=11
                     /translation="MYIRSTTRIGKVAAMAAVVAITVAGVAGGLAEGVSAAVISENKAT
                     AVFDVPGRNNIAPHLESLIKSAKRGSTIKYAAYLFSHKGIADALINAHENNDVTVQILV
                     SGKAPDEAKQQVSAVQDALKGGGDESWIKICEGGARKNSCQGTNAMHNKFLLIDDQEGT
                     APVVSTGSANLLGTSGGSGSGVAAPSDGYYDSWYTDVGNRGLYSRYEKYFADLENMKQS
                     ENYYAENGGPTATGNVKSYFYPRSGDGRPITMLEELGKTDCTKGGDIRVGHFSLKRPEV
                     LDKLIEKARDGCGTAIVVTRIDKSDCQKVARALKYGKLSLRVFHPDNPWYMHNKDVLID
                     GEYEGSRKKVVFAGSNNLNSLSEYSNDENLLRITDDRIFAEYRANWEFIKNVTSQEGKG
                     VHIRGVADCDKIG"
     gene            complement(16417..16887)
                     /locus_tag="AMK34_RS08015"
                     /old_locus_tag="AMK34_07965"
     CDS             complement(16417..16887)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK34_RS08015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AMK34_07965"
                     /product="hypothetical protein"
                     /protein_id="WP_073844014.1"
                     /transl_table=11
                     /translation="MTLKGILVRIAAAAATTALAFTAAPGIATAATQAESLFWIRFAAG
                     VQRCLDSNSAGSVYTHVCQDGNNHQKWNNYAPGKFKNKASGLCLAAGTSSVFAGSCEAN
                     ASDWRTSSTTNKYFTNVSTGLCLHNSGGQAEAVGLRVCRAGTALWTVTKLRS"
     misc_feature    complement(16884..16897)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.16"
                     /tool="antismash"
     gene            17254..17562
                     /locus_tag="AMK34_RS42960"
                     /old_locus_tag="AMK34_07970"
     CDS             17254..17562
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK34_RS42960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AMK34_07970"
                     /product="hypothetical protein"
                     /protein_id="WP_038512270.1"
                     /transl_table=11
                     /translation="MGFEVDVADISSAAGKLAAGKPPALAPGGAPNVGATHRAAGFAGD
                     YDVWLSTRQEDLVASQQQVTSLVEAIQAAAKSYDGTESAARDTFLKALDKGFAGIDR"
     gene            17559..18878
                     /locus_tag="AMK34_RS08025"
                     /old_locus_tag="AMK34_07975"
     CDS             17559..18878
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF026101.4"
                     /locus_tag="AMK34_RS08025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_07975"
                     /product="DUF4474 domain-containing protein"
                     /protein_id="WP_073844016.1"
                     /transl_table=11
                     /translation="MSSVFDKIRRLHDQVAKGSTTDLDDRARACRTTKEAVLDAKSLVE
                     AVRVQLAEGWQGGAGESALASLADFKKNRDDQAQDLEESAKSFEVVRDALAKAQGDARS
                     HLADAESLRQKLDGVWNDLSHGKGNIVFAWAQDKAIKARALVVLADLERVILGYDAVLL
                     AEGLKLRNKTGQVWELAGSGKRNLAEIAAIMLREIPGFAELVKNDPRLKAALLTGNWEL
                     LLQNREIAQKIYDYLGFKYVADGDYYTTGEHSVQSFLGWHDLYDKLEKLIGANLDKTGD
                     DGDNMEFTDPKTGKQYRLELWKGGYGFGGAFGGEVGFYTREPGSSDPSGYFNAAQGDDQ
                     IKVTQTIYDKTTDEVYFTNDGQGADGSDKKHFWNLGIRTDPNVDPSQLAQRATIEVRDA
                     GLRDQLYDEMTRWAAAHPDQNLTVTKTTDVPPALSYTWEK"
     gene            complement(18885..19121)
                     /locus_tag="AMK34_RS08030"
                     /old_locus_tag="AMK34_07980"
     CDS             complement(18885..19121)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK34_RS08030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AMK34_07980"
                     /product="hypothetical protein"
                     /protein_id="WP_073844018.1"
                     /transl_table=11
                     /translation="MSDPEQLARALRTTARNAATTALREGLEDIEERHGRRVADDVAGL
                     IDVDGVFTGLRETEIPRRSDDDEPWEFKRESLT"
     gene            complement(19131..19937)
                     /locus_tag="AMK34_RS08035"
                     /old_locus_tag="AMK34_07985"
     CDS             complement(19131..19937)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016335051.1"
                     /locus_tag="AMK34_RS08035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_07985"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_073844020.1"
                     /transl_table=11
                     /translation="MTTVEPVLLPEHEATTYAGWFACLAEPMRVKLLHAVATSPRGLTV
                     GALTEILGTSQSTCSHHVRKLAEVGFLHLRKEGTATVVTINQACCSGLPHAADAVMGLL
                     APRPCCPENLPEDVVVRALRDGDRDSVRRIHGEGIATFKAEVPSRETFGHRWVAEIGGE
                     VVGWAVAVPVSERECYRGVAETSVLVAESHRGRGVGKALMHKQVTEADAAGLWTLQTSV
                     FTDDRASIALHQSAGYRTVGIRERIVRRDGAWQDAVFLERRGPVTA"
     gene            20041..21360
                     /locus_tag="AMK34_RS08040"
                     /old_locus_tag="AMK34_07990"
     CDS             20041..21360
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020501805.1"
                     /locus_tag="AMK34_RS08040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_07990"
                     /product="NAD(P)-binding domain-containing protein"
                     /protein_id="WP_073844022.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 7.4e-11, bitscore:
                     38.7, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNELPVVVIGAGPVGLAAAAELVERGFEPLVLERGAGAGAGVAEW
                     NHVRLFSAWSELVAPAAGRLLEGTGWTRPDGEAYPTGSEWAERYLRPLATALGHRVRFD
                     AEVVGVARRGRDRVVDGGRDTEPFTVHVLAGDGSEERIAARAVIDASGTWSTPNPLGGE
                     GLPAIGERAAADRIAYRVPDLGDPAVRNRYAGGHVVVAGSGHSALTALVALSGLAKDAP
                     GTRISWVLRRGSVGNTFGGGDADQLPARGALGLRAQEAVKSGLIDVVTGFRTEALERDD
                     AGRLALISSAGQRIEHVDEVVTLSGFRPDLTWLSELRLELDPTLQAPVALAPLIDPNVH
                     SCGTVYPHGAKELAHPEKDFYLAGMKSYGRAPTFLAMTGYEQVRSIAAELAGDHEAATR
                     IELHMAETGVCGGAGLFDEPDDAASGGCCVTPETEVLTRS"
     misc_feature    20233..20235
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
ORIGIN
        1 ttccagaccg ctggtgaccg tgtccgcccc gactccgctg cggcatccgc ccatccagcc
       61 gagtccctga tcggtgagcg gcgcggcctc cggctcgggc ccaccggtca cgttcgggtc
      121 ggccgggccg tgcgttttgc cgaaggtgtg cccgcccgcg atgagcgcca ccgtctcctc
      181 gtcgttcagg cccatccgtt tgaaggtctc ccggatgtcg cgtgccgcga gcagtggatc
      241 gggattggtg gccgggccct gcggatcgac gtagatcagc cccatttcgg cggcagccaa
      301 cggttcgtcg agttggcgca ggccgctatg gcgttcgtca gcgagccatt tgcgttccgg
      361 accccagtac agctcgtcgg gttcgcacac ctcggcccgg ccgccgccga acccgaaggt
      421 cttgaacccc atggattcca aggcacggtt accggcgaag accatcaagt cggcccagga
      481 gatcttgcgt ccgtacttct tcttcaccgg ccacaacaac cggcgggcct tgtccaggtt
      541 gcggttgtcc ggccagctgt tcaacggtgc gaagcgttgc attcccgcgc tcgccccacc
      601 tcggccgtcg ctgacgcggt acgtacccgc ggcgtgccag gccatgcgca gcacaagagg
      661 accgtagtgg ccgaagtcgg caggccacca atcctgcgac gtcgtcagca cttcgtcgat
      721 gtcacgcgcc agttcgtcga gatccagcgt gtcgaatcgc tcggcgtagt cgaagtccgc
      781 gaacaagggg tcgtcctcgg gccgacgccg gcgcaaggcc gtcaggtcga cccggtccgg
      841 ccaccaatcg gtggcgtcgc cccccgccgc cggatgattc cgccgccggg gctgcctggt
      901 ctcgcccaga accttgtcgt aggtccggta gacgtgggta tcgggattct cgggcatcgt
      961 cgcctcccca agtgccatcg ccgctttgcc gccggaacgg ccacaccgct cagccgaaga
     1021 ccagtggcaa caggatcgcg gcgctgagca acgagatccc gctgaacagg tcggccctga
     1081 tccggacgac cctggcggcc atcctcccga cgtacagacc ggcgaacgac atgaccacgg
     1141 tcatcgcgcc gaacgtcagc atcgggacca cgagggagaa tcccgcgatt cccagcccgg
     1201 cgcccgcgat gaagttgtcg acggtcagcg aaagcggcat gccgaagagg gtcacccatg
     1261 ggtgatccat gtcctgcggc tccggatgac ggatagcccc gacgatgaag tacacgccgt
     1321 acaaccccag cgccgccgcc ccgatgtact cggcccaatc cccgaggaaa tcacccagat
     1381 agctaccgag gaatccaccc aagagcggcc ccaccgcgtc ccatatcccg aagacgaggg
     1441 cgacctgcaa ggcgcgccgc cagccgaacg ggatcgtccc gatggcgatc gacgagcgga
     1501 agttgtcgag actgagcccg aaggcgagcg cgagtagcgg caggaattca agcgacatct
     1561 gaaccacctc gaaagggcga gcagggtgac cagggagagc gggccggaaa cggttcattt
     1621 ccgatggccg gaactcacaa cccacaggga gctcgtgact tcgccggtgg actgtcgaag
     1681 ggcgtgacgc aaggcccgcg agaccgagtt tccgatccgg ggccttgcgt caacgccgac
     1741 gtagccggga agcaggtttt cgggtacctg ccgcgactac gggaaaacga acggcacggg
     1801 cccgggagcc cggccgtcag ccacggtaga agtagccggt ggcctcagca cacacctcga
     1861 cgaccgtgta ctccggagtt tcccacttca tatttcctcc tcgctgtcga ctacacccgg
     1921 cgacggggcg aaccgggcat tcgtgatccg cgcaaactcg aggacgaact cacgaaattt
     1981 cgcggtcatg aaagagcatc ctcgatttaa cgaagccggg gcaaccgacc ttgaaccact
     2041 gggtggcaac cggtgccgaa cggcgtcccg gcgcccacga acggagtggg cgggtgcacg
     2101 gacgggcacc gcaccctcac ccgccacgcc aggcccacgt cgccggtgcg gcgagtgctt
     2161 cccctcaccg gcgccgacca ctcacccatg tctccactga cgttgcgaaa gccactttcg
     2221 caacgttgaa ggttgcgaaa gtggctttcg caacccgcca cctttgacgc ctcacggccg
     2281 gagcccgaat cgccaccccg tccaccgaac gtggccgacc gcggccataa gaacttggcc
     2341 ttgacgtata aggcctttcg atggcgatca gccgactttc catccgtcga cccacgaatc
     2401 cgggattaaa ctgccgacgt gcgaatctac cttggctccg atcatgccgg actcgaactc
     2461 aagaaccact tcgtcgcaag gctctccgcg ctcggccacg aaacgatcga tgtcgggccg
     2521 tccgtctacg acgcgaacga cgactatccg ccgttctgtg tcgaagcggc acggcgcgtc
     2581 gtggccgacg aagggagcct cggtgtcgtc atcggcggtt ccgggaacgg ggaacagatc
     2641 gccgcgaaca aggtgcccgg cgcacgcgcc gcgctgacct ggagcgtgga caccgccaag
     2701 ctcgcccggc agcacaacaa cgcgctgctg gcgggtatcg gcgcccggat gcacacggtc
     2761 gaagaggccg aacacatcgt ggacgcgttt ctcggcaccg aattcgaggg cggacgccac
     2821 caacgcagga tcgacctgct gtccgagtac gagcgcaccg gcgaagctcc cgccctgccg
     2881 ggacactgac cgaggcggca agtccgtgaa ggcctccttg agggactctg ggtccctcaa
     2941 ggaggccttc acggacactc ggacggcacc tgcggccccg tgtgaaggcc cccttcacac
     3001 ggaatggcca agcccgagct gctgttcgat cttctcccag agaccgtcgt cgtccgagac
     3061 cgcgcggccg gcgtcatgga ccgcccacgc cgtcgtgacg acggaccgca gcagttcgtc
     3121 atcaccgacc gcgttcggca tgcgggacat ggcatccggc gtgaggtcgg aggagacggc
     3181 ccgcaggggc cttccaggcg cgagcagccc gctcaagtcg gcggcgacat aggtcggacg
     3241 cgcggacggc tcggcgcagg ccagatcgcg gagacgggac gcgccgctca ggacgaggag
     3301 cgaatcgagg ccggcagagt tggcaccttc gatgtcggtg tccagcaggt ccccgcacac
     3361 cagggtctcg gagtgaacgg tgccgagccg gtgacgcgcc aggtcgaaca gggccgctcg
     3421 tggtttgccc accacgtgag gggatgcgct ggtggcggtc cgcaccaggg cgaccaacgc
     3481 cccgttgccc ggcgcccgcc cgtacggcgt gggcaaggtg aggtcgacgt tcgtggccac
     3541 ccaggtggct cccgcgtcgg cgagcctgcc caccgccgcc agctcacgcc aggtgacgtc
     3601 ggttcccagc ccctggacga cggcctccac cggcgtaccg tccagatccg cgacacggac
     3661 cggggtcaac ccggcctccg tgagcgcacg ggcgacgcct gggcctccca ccgcgaacac
     3721 gggtgtcccc ctgccaagac gctccgccag atgtgccgcg gccgcctgcg aactggtgac
     3781 caccgaccaa ccccgcgggg cgactcccag cccgcgaaga tgctcgctca cctcctcggg
     3841 tgggcgggac gcgttgttgg tcgcgaacac gaccggggtg ccccgcgccg tcacgcggtt
     3901 caaggtctcc accgcatggg gaacggccga ggggccgcgg tagaccacgc cgtcgaggtc
     3961 gcagatcagc ccgcggtacc gcgtgatcag cgcatcgttc ccggtcttct cagccgtcat
     4021 gcggttcggc gcccctcctg ctcgcgccga gcgacgtgcg ggcgttcgga ccgcaccatc
     4081 cgcactgtct ccggcttcga cgacatcacc agagactggg tgaagacgcg gccagagtgg
     4141 tgctggacac ctcgcaacaa ctcgcttccg gtcagccccg tggcgcagaa gaggatgttc
     4201 tccccaccca ccaggtcttc ggtgtggagg accttccctt cctgcagccg ggcctgcagc
     4261 gcgccacccg aacaggtcag ggcggccgcg gcgatcaccc cttcggccgc tcccccggcg
     4321 cccagcagga tgtccactgg gctctcgggc cgcgccaccg cgatcgcgcc ggagacctca
     4381 ccgccttcca gcaaatggat ccgtgcgccc gcgtcgcgga tctcgtggac gagatcccgg
     4441 tggtacgggc ggttgagcac ggcgacgacg acgtccgaca cgcgaatgtc cttggccttg
     4501 gcgaccgctc gcaggttctc cgccaccggg cggcggatgt cgacgacgtc gacgcactcg
     4561 ggaccgacgg ccagcttctc catcgaggca cccggcgagg ggtcgaacaa cgcaccacgc
     4621 tcggcaacgg cgatcgcgga cagggagtac ggcacgtcct tgaccggcga gagcgcgccg
     4681 tcgcccgcgg tgatggcgac gtcgcacgcc gggccgtccc cgctcccgac gtcgtcaccg
     4741 gcgaacagga ccggcgtggc gcccttcccg tccgcgcccg ccaccacaac accgcgcatc
     4801 cgcaccgacc cgaggagttc gcgcatcacg tgggcggcgg cctcgccgct gttcccgtcc
     4861 ccgaacccga cccattcgcc cgccgcgatc gcggccgcct cggtgacgcg cacgagttcg
     4921 agcgcgagag cctgaccgga gcccccggcc gccatccctg gacgtccggg gatgtcccat
     4981 tcctgagtat tcatcgttct cacttcactc ggccgagcaa ggaaacagca ccgcgggcga
     5041 ccggcccggc cgtccgcgtg gccggaccgg tcgcccttca agcggacgcg aaccgcattc
     5101 agcgggcggc ggcgttcgcg accgctcgtt cggagagcgc gttctgggcg gcgacccggt
     5161 tgccttcgtc accccgccag gcctccaggg cgggcccgac gagcgcccgt ccgaaggagt
     5221 aggtgagctc ccagggaagc gggtcgagtt cctgcatcgc cccgaggtgc tgtgtcgcca
     5281 cctccgggct ttgcccaccg gaaaggaacg cgatacccgg cacggacgac ggcacggtct
     5341 cccgcagggt ctccaccgtc gcccgcgcga cgtcggccac cgtgggccgc tccgggctcc
     5401 cggtcccggc gaccaccatg ttcggcttga ggacgatgcc gtcgagccgc acccgcatca
     5461 gatcgagttc ctcgaacagc gactccagta cggccgtggt cacctgacgg caacgctcca
     5521 gcgtgtggtc cccgtccatc aagacctcgg gctcgacgat cggaaccaga ccggcctcct
     5581 ggcagagacc ggcgtaccgc gccagggcgt gcacgttcgc gcgcaccgcg cgggccgaag
     5641 gctcgtcctc gccgatcgtg atcacggccc gccacttggc gaacgtcgcg ccgagccgca
     5701 cgtactccgt cactcgttca cgcaggccat cgaggccctc ggtgatcttc tcctccggcg
     5761 atcccgccag cggcttcgct cccgtgtcga ccttgatccc ggtgagaatc ccgatgtctt
     5821 cgaggaactc cgggaacgtg cgcccgtcac tcactttctg gtggaacgtc tcgtccgcga
     5881 ggatgatccc gctgacggat tccgagagcc gcggcgtcgt gacgatcaat tcccggtaga
     5941 tccggcgatt ttccgcggtc gcttcgacgc ccaccttctc cagcctggcg gacatcgtcc
     6001 cgatgctctc gtcggcggcg aggataccgc gccgatcgga gaccatcgtg cgagcgatct
     6061 tgttcagggc tgacatctac tgttgctcct cctgtatcgg acaccggatg gtgtgacatt
     6121 tccgcgagag gtctgagtca ggtcatcgat ccgtgtccct cgcctgccaa gctgggctct
     6181 cgcgagtgct tgcgcttccg ccagtcgacc gtcctcggtt gctgccccgg cacgacgacc
     6241 ggcggcatcg ggctgccctt ggacaccgcg atctccagta attccttcgc gtggtccggg
     6301 agaccccggc gttcgctcca agccgcgtaa atgggtttgg ccggcatctc ctggtcgacg
     6361 gtcaccaggt gcagccggcc ttccgcgagt tcggaccgca cggtggagac gttcagcacg
     6421 gtcacccgct tgctggtcgc gaccgtctgc ttgatcgcgg cgctggaagg gaattcgacg
     6481 tagccgcggg ggacccggga ggttcccagc agttcgtcgg tgaactcgcg cagccctgag
     6541 ccgcgctcgc gcagcacgag cggggcggcc gccagctcct gcaccgtcaa cgggctgcgc
     6601 ctcgccgccc aagggtgcct cgagccgacg accacggcca gtttgtcgtc gcagatgtac
     6661 cgggtcatca ggtcctcgcg ggactgttcc cgcccttgcc ccccggcatg gcaccagccg
     6721 tcgatgaacg cgagatcgac gtggctcgcg cggatcagcc ggtgcagtgt ctccacgctg
     6781 cctgtccgaa cctcgacacg cgcctcaccg aacgagaaac ccgaccggtt cagccattcg
     6841 gggatcaaat gctcggaaac cgccgggctg cccgcgatcc ggagccgttt cgcgtcggaa
     6901 gacctcgccc ccgagccgaa ttcgagcaac tcccttgccg cctgcatgac attgcgggcg
     6961 tacttcgcca gcatctcccc gtcttcggtg agcttcgatc cggcgggaga gcgctccaga
     7021 agcttgagcc cgagacgtcg ttccatcgcg ctgatccgga tactggccgc gggctgggaa
     7081 aggctgtgcg cttgcgcggc ctttcccacg ctcccgtggc tttccaccga gagcagcaga
     7141 tcgaggtctg cgagctgagg catcttcgac ggaagaacca cggtttcacc tctcattccg
     7201 gacttcgtcg tgctgtcacg ttcgttcgca cgggacgccg ggaatatgcc gatcgccacc
     7261 ggcgccccgt gctgtggacc gagcctgcgg ggagcggaac gcagggtcaa tccgtccggc
     7321 acgaacgtcc ggcacccgag cacgaacggt gtgcaccaag ccatttacgg gccgaaacgg
     7381 aagccgggcc ggaggtgaaa gggctcacac tccctttcgt cgcggcgaag accccgttcg
     7441 tcctcgatcc accgccgttc gttctcgcgg atcccgtcag agtgccgcgt cacacgctcg
     7501 tgcggcgcgg atcaggagga gctcggcccg ctcctcacga acgaccttca gcacatcgtc
     7561 cgagagcagt ccgctctcca tcacttcgtc ggtgtccgcc agcacgctga gctcgtcttc
     7621 ggtgaaccgt ggatagagcg cgcgggcgaa cgcgagtacg aactcgggcc ggccggtcgc
     7681 cgcgaggtcc ttcaacgatc gccaatagtg gtcggtgtac cgggtgagca aggcttcctg
     7741 ccccggctcg cgcaaccccg ccatgacggc tttcttttcc gcgagcgaaa ggtcgtcgcc
     7801 ggtcgaccgc gcccacgcct cgtccttcgc cgcgacggtg gggcgtgcgg cttccaccat
     7861 caaggcgttc cggtggccgc tgtcccctgg atcggcttcc cgcgcgacgt ccagcagtcc
     7921 gccgacgtcg cgtccgatag ccgcgaggcg gaacaggctc cgccaccgga gatcccggtc
     7981 cacttccagt ccggcccagg gagatcgtcc gcacacgatc tcctgcagca gaccgtgccc
     8041 ctcggcccgc acgaccccca cgaggacacg ggcgaacacc aattgccgat caccacccgg
     8101 cgcggcggcc gccagctgtt cgtggatccg gcgcgccagg ccttcgagcg cctggcgccg
     8161 atcggcaggg gcaccataga cccgcaccgc ttgtacggcg cgctccagaa gcgccttcag
     8221 gaccccgtcg tcgtcctcat gtacaccgtg ggtgagaacg gccgatgcgt agcttcgtgc
     8281 gggtagtcgc gcgtcgagca cgtcgtccca cagcgctccc cacacgaccg cgcgcgcccg
     8341 ccgatcgtcc aaggtggaca gagctcgtaa ggccgtccgg cgggatcgtg gatccagcct
     8401 caccttgacg tggcataccg cgtcgtcgtt gggcaccagc aggtccggac cgccgaacgc
     8461 ggtgaggtcc tcttcggacc tgccgggggt gagcacgacc ggcacccgcc gccgtggcac
     8521 cagcttgccg tcgtggtcct cgaaggcggc gacacgcaga ttcaggtgac gcggcaggac
     8581 ttccggatcg ggaagctgta ccagccggtc accggcggcg aggcgggaca cctcgaccgt
     8641 gttgacgccc cggcgcagca gccattcgtc cacccatcgg cccagatcct cgtccgagga
     8701 ctgtctcagc gccgccacga agtcgtcgag ggaggcgttt ccccacgcgt gtgctcgcag
     8761 gtacgtccgt accccggcga agaaggtctc ccatccgagt cgcccggcga gatcgcgcag
     8821 gaccgcggct cctcgtttgt agacgatcgg gccgaaattc acccgcgcgg cgtcggtgtc
     8881 gacggtttcg acccggatcg cgtggccggt gggcaaccgg tcggcgtgcc gggccaccgg
     8941 cagggagtgg tgcgcgtacg cggtccagcc ttccccgtac cgcgtcgcgt cgcgctgcgc
     9001 gatgatcgac atcagctccg cgaacgcctc gttcagccac aggtcgtccc accagcgcag
     9061 ggtcacgtag tcgccgaacc acatgtgcgc catctcgtgc agcagcacct cggcccggcg
     9121 ccgccgttcg tcgtcggtga cccggtgccg gaacaggaac cgctcgttca gcgtgacgca
     9181 gccaggatgt tccatacccc cgaacgcgta ttcgggcgcg aagacgtggt cgtacttggt
     9241 gaacgggtac ggcagggcga acgacccgcg gtagaagtcg aggccgcggc cgatcacgtc
     9301 gaacaactcg ggcgcgtcct cgacgagctc ttcgaagagc gagtcccgcg cgtacagtgc
     9361 cagcggcact ccgcggtggt gggagcccag ccggcggaac gagccgacgg cgaaggccac
     9421 cagatacggc ggcagtggtg gtgtgggttc gaaacgccac gccgtccgcc cgcccgcggt
     9481 ccgcgattcg acggggtcgg tgttggcgac caccaccgcc tggtcggagg cggtgacggt
     9541 cacttcgaca ggggccttca ggtcgggctg gtcgaaacag gcgaacacct tgtgcgccgc
     9601 gaaaggctgg aacttcgtgt gcaggtagac gtggccgtcg agcgggtcac ggaaccggtg
     9661 cagcccctcg ccggttcgcg agtacggagc ggtaccggcc accctgaccg tgttcgcacc
     9721 cggccggacc tccagccgga cgcgcgtccc gttctgcgcg tccggcccca gcgcacggcc
     9781 gttgcactcg accgactcga cctctcccgc gaagtcgagg aagacgaacc cgattccggt
     9841 cctcgcctgg aagcggacca ccgtcgtcgt cgcgaacgtc cgctccccca gtgtcacatc
     9901 gaggtccact gtgtactgga caccgaagat cgcggcggac cgcgccgtgg cttcgtcccg
     9961 cgtcaggggg cgtccggcac gacttccggc ggacatgcgg tcatcgcctt cgggccgaga
    10021 cggtcggccg ccggtagacg agccgctcgc ggatcacctc gccgtccgcc gcgacgtcct
    10081 cctgattggc ccggacgagt gccgactgga ccaggtgatg atccggtgag tgctggcaca
    10141 ccggatcggt acggcccgca tcgccggtca gcgcgaacgc ctggcaccgg caaccgccga
    10201 agtccagctc cttgcgcgga cagccgcggc agggatcggg catccactcc gtgccccggt
    10261 acgcctcgaa cgcggcggat ttcgtccaga tccactcgag gtcgtggtcg cgaaccgagg
    10321 agaactccat cgtcttgatc tccgcggcga caggacacgg gtagaccacg ccgtccggcg
    10381 ccacggtcag cgcggtctgc gcccagccgc ccatgcacgg cttcgggtag ggctcgtagt
    10441 agtccggcag gatccagagc atctccatcc gctcggccag ctccgccttc cggcgttcgt
    10501 agacgccgac ggcctcgtcc agctgggatt tgctcggcat cagcgactcg cgattgcgca
    10561 gagcccagcc gtagtactgg ctgttcgcga gttccagccg ctcggcgccc catttcacgc
    10621 agacgtcgat gatcgcgtcc agccggtgca ggttcagccg gtgcagcacc acgttcatgt
    10681 tcaacggcag cccggcgtcg cggatgatgc ccgcggccgc ttccttcttg tcgaaccgtt
    10741 tgctggccgc gaccaggtcc gtcgactcgg cggcgtcccc ctggatgctc agctgggcgc
    10801 tgttgaggcc cgccgcgacg agcgattccg cccgggcctc ggtcagcccg aggccgctgg
    10861 tgatcaggtt cgtgtacagg ccgagacggc ggcactcggc gaccaacgtc tccaggtcgc
    10921 cgcggacgag gggttcaccg cccgaaaagt ggacctggac gacgccgagc ccggccgcct
    10981 cgccgatcac cctcacccat tcgtcggtcc cgagttcgtc ctcccgctcg cgcagctcca
    11041 acgggttcga gcagtagacg cagtgcagcg ggcaccggtg cgtgacttcg gccagcaggc
    11101 cgtacggctg cggggtcccg ttcatgtgac caccacccag ccccgtccgc tcgcgtcacg
    11161 gaggaacgtc atcacgtcgt tcaccagatc ggtcgcctcg aactcctgct cgagccgctc
    11221 gaccacctgc cgcacggtcc ggctgccgtc gcacaggccg aggatcgccg ccccggactt
    11281 gttcaggagc accacccgct ccggcaacag cagaagctcc acgtcgcgga cgctgtcatg
    11341 cttgagcatc gccttcgtcg ccaagcgggg cgtggccgcc agatcgccgt cgtccatcac
    11401 gaacccttgc cgtacgcgaa ctgcacggcg tccaacaggc tccacaagac atcgcatttg
    11461 aactccaggg ctcgggcgca cgcgtcctgc tgcgccctgg acttcgcgtg ctccagcacc
    11521 agctcgagca gatgcgcgat gtccttgggc tgctgggtca ggcgcgcccg gaagtactcc
    11581 aggccttcct cggcgatcca cgggtaatgc cgccggacgt cggtgatccg cctgctgagc
    11641 agatccggcg cgaacagttc cgtcagcgcc gacgccacgg attccagcca cggcttctgc
    11701 cggcaaaagt ccacataggc gtccactgcg aaccgtactc cgggcagcac cgtgtcgacg
    11761 tcgaacagtt cttcgcgggt caggccgacg gcctcaccca agcgcaccca tttctcgagg
    11821 ccgccttcgg ttccttcgcg cccatcgtga tcgatgatgc gctggatcca ccggcggcgg
    11881 tccgcccggc cgggcagttt ggtcaggatg aacgcgtcct tcaccggcag gttcagctgg
    11941 tagtagaagc gattgcgcac ccagccccgg aactcttcct cggtcagcgt tcccgaatgc
    12001 atccgttcgt tgaacgggtg cagatggtgg taccgcttct ccccgatcga ccgcagccgt
    12061 gcttcgaact cctccgcgga ccaagggttc atacttccac ctccaagcct gctcgaccga
    12121 tctcgatgcc caggctcgtc agccaccgcc gctcgccgga cccttcgtcg aggatcgggt
    12181 tcgtgttgtt gatatgcgtg tagatcttcc gtttcgccgg aagcgccgcc aacgcacggg
    12241 ccgaaccgtc ggcgccgccg acgggcatgt gtcccatgga ccttccggtc cggcttcccg
    12301 caccctggca ggacatctcg tcgtccgtcc aaaatgtccc gtccaggaag acgcaatcgg
    12361 ccgaggccac ctgctcggcg aacttcgcgt cccagcgcgg cagcgtcggc gcgtacacga
    12421 cggttccgcc cgtcaccttg tcttgcagac ggaaacccac ctcccactcc gacgagccgc
    12481 gctgcggcgc atgccgcgac ttcccgacat agcgcggcgc cttggaaccg gtcaggaagg
    12541 cggtcgcccg tagccggtcg tccaggtcca gcggcttgcc gatttcgaga agcgaccagg
    12601 aaagatccgc gtaatcgctc agcagttccc ggaccgggaa ccacgaactc agcgcctcca
    12661 gcacgggacg ggtcccgtag accttcagcg acgactcctc acgcaacatc agcaggccga
    12721 tcgtgtgatc gaactccgcg tccgtcagga gcacgccggc caccggcgtc gcccggatcc
    12781 ccggtcccgg atgcaaggcg ggatccgccg cgatctggtg gtggacgtcc ggggtcgcgt
    12841 tgagcaggaa ccatcgctca ccgtccccgg aaaccgcgag accggcgtgc atcgtcgcga
    12901 cttcgggctt cgctcgggcg gtacggcatc cggcgcacgc gcagttccat tgcggaaaac
    12961 cgccgcctgc cgcgactccg aggcaatgaa cgaacacgcg tcctccctcg aatccggccc
    13021 ctggcagcgg ccgtgacctg aactcggttt gtcttcgccc accttcttcg tccacgccgg
    13081 ccctgacaat cgatcgcgca cgaccggcgc cgaatctctg acgaacggcg accccgccgc
    13141 cacgagcgga tcgccgcggc catggacggg accggcggag ccgcgctccc ggggaacggt
    13201 gtggttattc gttgtgtgta tcgggggatt gtgttttcgg atgtggtggg gtgttgccgg
    13261 ttggtgttgg ggtggtgatg gtggtggggt tctggttttc gttgtggtga ggagtgttgt
    13321 tgtggagttg caggttgcgt tggatgtgct ggatctgccg tcggcgttga cgttggcgaa
    13381 tcaggtggcc gggcatgtgg acattttgga gctggggact ccgttggtga agtcggcggg
    13441 gatcggtgcg gtgtcggcga tcaaggcggc gttcccggac aagctggtgt tcgtggatct
    13501 gaagacggcg gacgcgggtg agctggaggc gacgctggcg ttcgaggcgg gcgcggatct
    13561 ggtgacggtg atgggcgccg cggacgacga cacggtgcgg ggtgcggtcg ccgccgggaa
    13621 gaagtacggc aagcaggtgg tggcggacat gatcaccgtg gtggacgggc gggtgtcccg
    13681 gatccgggag gtcgcgaaac tcggggtgtc gttcgtggag atccacgccg gtctggacga
    13741 acaggcccgt cccggctaca cgatcgagca gttgctgcgc gacggcaggg aagcgggagt
    13801 gccgttctcc atcgccggcg gcatcaagat cgacaccatc gcctccgtcc gtgaggcagg
    13861 cgcgaaagtc gccgtcgccg gaggcgccat ctacaacgcc accgaccccg ccaccgcagc
    13921 caaagaactc aaacaacgcg ccacccgcta ggaaggagtc ggcgtggaag gccagaagac
    13981 caatgcccgc cacgacacct attgctcctt gatgctgcag gccgccggcg tgcttaggtt
    14041 gcgctacgcg gaatgcagcc aggacaccac gttgtccccc gccgcggcga accagctagc
    14101 ggacgtcttc gagagtgtcg cgcacgggga tccggcttac gaccagatcg atccgaagga
    14161 ggcgatcgcg ctggcgcatc gcctgctcga cgacgaccac cctgagctgt cgaggatgtg
    14221 gcccaggacc aggtgatggg ggcgccggtc caccggccgt gcgcgagccg gtggaccggc
    14281 gaaatcaagg atcattcgca gctcgacgag gagtacacga tgaccactgc cgttgccacc
    14341 gaagcccccg cccgatccgc gcccacgggc gaccccgccc tgatcggcgt ccccaccttc
    14401 atcgtcggtg cgaccgcgct cggcctggtg ctgaccggct acgtgccggc cgccgcggtc
    14461 ggcgcctcga tcgcgatcat cctgcccgcc accggtatcg gccagctggt cgccgccgta
    14521 tgggccgccg cgctgggcga aaacgccgtc gccgcggtgt tcgggatctt cgccgggttc
    14581 tggctcagtt acgcggcgct ggtactcggc ctgatccacg gctggttcgg catcaccccc
    14641 gacgcggcgg tcgcgacgca aggcctgttc ctgatcgcct ggctggtcac gatcgtcctg
    14701 ctgaccctga ccacactgcg gctgcccgcc gcgttcacgg tcctgttcgt gttggtcgac
    14761 atcgcgctcg cgctggtgct gtacggcacc gtcggcggct ccacggcggc caccacggcg
    14821 ggcggctacg ccgtgttcgc gttcaccgcg gtcggcgtgt acctgttcgc cggcgcggtg
    14881 tccaccgcga ccggcggcaa gccactgccg ctcggccgtc cggtattgac ctgacccgga
    14941 cgcgaaatcc gtatagttct ccccggcgcc gaccgtatgg cgtcggggag acgtttgcgt
    15001 cggagatccg gtcaaccgat cttgtcgcag tcggctacac cgcgaatatg gacccccttg
    15061 ccttcttgac tcgtcacatt cttgatgaat tcccagttcg cccggtactc ggcgaagata
    15121 cgatcgtccg tgatccggag aaggttctcg tcgttgctgt attcggacag cgagttgagg
    15181 ttgttgctgc ccgcgaacac gaccttcttc ctggacccct cgtactcccc gtcgatgagc
    15241 acgtctttgt tgtgcatgta ccacggattg tccgggtgga agactcgcag gctcagcttc
    15301 ccgtacttga gcgccctcgc caccttctga cagtcggact tgtcgatcct cgtgacgacg
    15361 atcgcggtac cgcacccatc tcgcgccttc tcgatcagct tgtcgagaac ctcgggacgc
    15421 ttgagggaga agtgtccgac ccggatgtcg ccccccttcg tgcaatcggt cttgccgagc
    15481 tcttcgagca tggttatcgg ccgaccatcg cccgagcgcg gatagaagta gctcttgacg
    15541 tttcccgtag ccgtcgggcc accattctcg gcatagtagt tctcggactg cttcatattc
    15601 tcgaggtcgg cgaagtactt ctcataacgg gaatacaatc cccggttccc gacgtcggtg
    15661 taccagctgt cgtaatatcc gtccgacgga gcggcgaccc cactcccgct cccaccggag
    15721 gtgccgagca ggttcgccga tccggtggag accaccggcg cggtgccttc ctgatcgtcg
    15781 atcaacagga acttgttgtg catcgcgttc gtaccctgac acgagttctt gcgcgcgcct
    15841 ccttcgcaga tctttatcca ggattcgtcg ccaccgccct tcagcgcatc ctgaacggcg
    15901 ctcacctgct gcttcgcctc gtccggcgcc ttgccactga ccaaaatctg aactgtcacg
    15961 tcgttgttct cgtgagcgtt gatcagcgcg tcggcgatcc ccttgtgcga gaagagatag
    16021 gcggcgtatt tgatcgtcga accgcgcttg gccgacttga tcaaagactc cagatgtggg
    16081 gcgatgttgt ttcggcccgg aacatcgaag accgcggtcg ccttgttctc ggagatcacg
    16141 gctgccgaca ccccttcggc gagcccaccg gccacgccgg cgacggtgat cgccacgacg
    16201 gcggccatcg cggccacctt gccgatacga gtagtactgc ggatgtacat ggaccttccc
    16261 ctctgagcgg tacccgtacc ggctcgaagg tgctgcctga cctggccgtc tcaggcagcc
    16321 cgcggcacgt ggcgttcctc gacaccaaga tcccgtcgtc cccgggggac gacaacacct
    16381 tttcgccgag tcgaaaaccc gctccgcggc ttcgaatcag ctccgcagct tcgtcacggt
    16441 ccacagcgcc gttcccgcac ggcagacccg gagcccgacg gcctccgcct ggccgccgct
    16501 gttgtgcagg cagagcccgg tcgacacgtt ggtgaagtac ttgttcgtcg tggacgacgt
    16561 ccgccagtcg ctggcattgg cctcacagga cccggcgaaa accgatgacg ttcccgcggc
    16621 gagacatagt ccggacgcct tgttcttgaa ctttccggga gcgtagttgt tccacttctg
    16681 gtgattgttc ccatcctgac aaacatgcgt gtacacgctg cccgccgaat tggaatccag
    16741 gcagcgctgg acacctgccg cgaacctgat ccagaacagc gactcggcct gcgtcgccgc
    16801 ggtggcgatg ccgggtgccg cggtgaacgc caatgccgtg gtcgcggcgg ccgccgcgat
    16861 tcggacgaga attcccttga gtgtcatgat gattctcctc atggccgact gatacgaatt
    16921 tccggatatc caacgatcac ccatgaaatg tacaaatttc gaaatcccca cgcccccgaa
    16981 cggaaatcga cgttagcgcc tgcaagaccc gatttcgtgg atcgatcacc gaaagcactc
    17041 caatggagga atacgtgatc acacgacacg ccgattcgcc acccgcacac tccacgttca
    17101 gagcagtgcg gtcacccatc cggacgccac tgcccccgcg cgcgtcgtcg agcgggcgcc
    17161 tccatgcgac caaaagcgtg aacagggcac caaaccagaa gttgggtgtt acattgccta
    17221 ggcgaagtgt cacacggtcg gggagggcgt gctgtgggtt tcgaggtcga tgtcgcggac
    17281 atcagcagcg cggcgggcaa gctcgccgcg gggaagccgc cggcgctcgc ccccggcggc
    17341 gcgccgaacg tcggtgccac ccatcgggcc gccgggttcg cgggagacta cgacgtctgg
    17401 ctgtcgaccc ggcaggagga tttggtggcc tcgcagcagc aggtcaccag cctggtcgaa
    17461 gccatccagg ccgccgcgaa gagctacgac ggcacagagt cggccgcgcg cgacactttc
    17521 ctgaaggcgc tggacaaggg cttcgcgggg atcgaccggt gagctcggtc ttcgacaaga
    17581 tccgccggct ccacgaccag gtcgccaaag gcagcacgac cgacctcgac gaccgggcgc
    17641 gggcgtgccg gaccaccaag gaagccgtgc tggacgccaa atcgctggtc gaagcagtcc
    17701 gcgttcagct ggccgaagga tggcaaggcg gagccggtga gtcggcgctc gcctcgctcg
    17761 cggacttcaa gaagaaccgt gacgaccagg cccaagatct cgaagagtcc gcgaagtcgt
    17821 tcgaggtggt ccgcgacgcg ctggccaagg cacagggcga cgcccgcagt cacctcgcgg
    17881 acgccgaatc cctgcggcag aagctggacg gcgtctggaa cgacctttcg cacggaaagg
    17941 gcaacatcgt cttcgcctgg gcacaggaca aggcgatcaa agcgcgggca ctcgtcgtgc
    18001 tcgccgactt ggagagggtc atcctcggtt acgacgcggt cctgctcgcc gaaggcctga
    18061 aactgcggaa caagacgggc caggtatggg aactcgcggg ttcgggaaag cggaacctcg
    18121 ccgagatcgc cgcgatcatg ctgcgtgaga tcccgggttt cgccgagctg gtgaagaacg
    18181 atccgagact caaggccgcc ctgctgaccg gtaactggga actgctcctg cagaaccgcg
    18241 agatcgcgca gaagatctac gactacctcg gcttcaaata cgtcgcggac ggcgactact
    18301 acaccaccgg cgaacactcg gtacagagtt tcctcggctg gcacgacttg tacgacaagc
    18361 tcgaaaagct catcggcgcg aacctcgaca agaccggcga cgacggcgac aacatggagt
    18421 tcaccgaccc gaagaccgga aagcaatacc ggctggagct gtggaagggc ggttacggat
    18481 tcggcggcgc gttcggcggc gaagtcgggt tctacacccg cgaaccgggc tcctcggacc
    18541 cgtccggcta cttcaacgcc gcccagggcg acgaccagat caaggtgacc cagacgatct
    18601 acgacaagac caccgacgag gtctacttca ccaacgacgg ccaaggcgcc gacggcagcg
    18661 acaagaagca cttctggaac ctggggatcc gcaccgaccc gaacgtcgat ccgagccaac
    18721 tggcccagcg cgccacgatc gaggtgcggg acgcaggcct gcgcgaccag ctctacgacg
    18781 agatgacccg gtgggccgcc gcgcaccccg accagaacct caccgtcacc aagacgaccg
    18841 acgtcccacc ggccctgagc tacacctggg aaaagtgacc ccgctcaggt caaggactcc
    18901 cgtttgaact cccacggctc gtcgtcatcg cttcgccgcg ggatctcggt ttcccgcagc
    18961 ccggtgaaca cgccgtcgac gtcgatcagg ccggcgacgt cgtcggcgac acgccggccg
    19021 tggcgctctt cgatgtcttc gagcccctcg cgcagggcgg tggtcgcggc gttcctggcc
    19081 gtggtccgca acgcacgggc cagctgctcc gggtcactca tgaacccact ctaggcggtg
    19141 accgggccgc ggcgttccag gaagacggcg tcctgccaag cgccgtcgcg tcggacgatg
    19201 cgctcgcgga tgccgacggt gcgataaccg gcactctgat gcagggcgat ggaggcgcgg
    19261 tcatcggtga agaccgaggt ctgcagcgtc cagagcccgg ccgcgtcggc ttccgtgact
    19321 tgcttgtgca tcaaggcttt acccacgccg cggccacggt ggctttcagc gacgaggacg
    19381 gatgtctcgg cgactccccg atagcactcg cgttccgaaa ccggaactgc gaccgcccag
    19441 ccgacgacct cgccgccgat ctcggcgacc catcggtggc caaaggtttc gcgactggga
    19501 acctcggctt tgaaggtggc gattccttca ccatggatcc ggcggaccga gtcccggtcg
    19561 ccgtcgcgca gcgcgcggac gacgacgtct tccggcaggt tctccggaca gcacggacgc
    19621 ggggcgagca ggcccatcac ggcgtcggcg gcgtgcggca gcccgctgca gcaggcctgg
    19681 ttgatggtca cgaccgtggc cgtgccttcc ttgcgcaggt gcaggaagcc gacctcggcc
    19741 agttttcgga cgtggtggga gcacgtcgac tggctggttc cgaggatctc cgtgagcgcg
    19801 ccgacggtca ggccacgcgg cgaggtcgcg accgcgtgca ggagtttgac ccgcatgggc
    19861 tcggcgagac aggcgaacca gccggcgtaa gtcgtggctt catgctcggg caggaggacg
    19921 ggctcaaccg tggtcatgcc gcccagtatc gaccggaatc gatggttgcg tcaatcgatt
    19981 gcggtcgata cagtccccgc atcgcttcaa tcgagacaga tcgatgaaag gtgcatgggg
    20041 atgaacgagc tgcctgtcgt ggtgatcggc gcgggaccgg tggggttggc ggcggccgcc
    20101 gagctggtgg agcggggttt cgagccactg gtgctggaac gcggcgcggg ggcgggcgcg
    20161 ggagtggccg agtggaatca cgtgcggttg ttctcggcct ggtccgagct cgtcgctccg
    20221 gcggccgggc ggttactgga gggcaccggc tggacgcgac ccgatggcga ggcgtatccg
    20281 acgggctcgg agtgggccga gcgttatctg cgacccctgg cgacggcgct cggccatcgg
    20341 gtgcggttcg atgccgaggt ggtcggtgtc gcgcggcgag gccgggatcg cgtcgtggac
    20401 ggcggccgcg acacggagcc gttcaccgtg catgtcctcg ccggggacgg ctcggaagag
    20461 cggatcgcgg cacgggcggt catcgacgct tcggggacct ggtcgacgcc gaatcccctt
    20521 ggcggggaag gacttcccgc catcggcgaa cgagcggcgg cggaccggat cgcctaccgc
    20581 gtgccggatc tgggcgaccc ggcggtgcgg aaccggtacg cgggcggaca cgtggtggtc
    20641 gcggggagcg gacactcggc gctgaccgcg ctggtcgcgt tgtccgggct cgcgaaagac
    20701 gcgcccggta cgcggatcag ctgggtgttg cgccgcgggt cggtcggcaa caccttcggc
    20761 ggtggcgatg ccgaccagct cccggcgcgg ggagcgctcg gcctgcgggc tcaggaggcc
    20821 gtgaagtccg ggctgatcga cgtcgtgacc ggattccgca cagaagcgct cgaacgcgac
    20881 gacgcgggga ggctcgcgct gatctcctcc gcgggccagc ggatcgagca cgtcgacgaa
    20941 gtggtgacgc tgtccgggtt ccggccggac ctgacctggt tgtcggagct ccggctggag
    21001 ctggacccga ccctgcaggc gccggtcgcc ctcgcgccgc tgatcgatcc gaacgtgcat
    21061 tcctgcggaa ccgtctaccc gcacggcgcg aaggaactcg cccacccgga gaaggacttc
    21121 tacctggccg ggatgaagag ctacggccga gcgccgactt tcctcgccat gaccggttac
    21181 gaacaggtcc gcagcatcgc cgccgaactc gccggtgacc acgaagcggc gacgcgcatc
    21241 gaattgcaca tggccgaaac cggcgtatgc ggcggcgccg ggctgttcga cgagcctgac
    21301 gacgcggcgt ccggtggatg ctgcgtcacg ccggagacgg aggtcctgac acggtcgtga
    21361 ccctcgcccg cgcggttccg atcactccac cggcgctttc gtggtccagc gtttccgcag
    21421 ccggagactc acgtacacca gggcgaccag caccgggacc tcgatcagcg gtccgacgac
    21481 cccggcgagc gcctgacccg acgtcacgcc gaaaacgccg atggcgacgg cgatcgcgag
    21541 ttcgaagttg ttgcccgcgg cggtgaacgc cagtgtcgtg gtgcgttcgt aggacagccc
    21601 ggacgccttg cccagcagat atccgctggt ccacatgacg gcgaagtagg caagcagcgg
    21661 caaggcgatc cgggcgacgt cgagaggccg ggacgtgatg gtctcccctt gcagggcgaa
    21721 caggatcacg atggtgaaca acaggccgta caacgcgacc gggccgatct tcggcaggaa
    21781 cgtgccctcg taccactcac ggcccttgtt ccgctccccc gcgcggcggg acagatagcc
    21841 cgcggcgagc gggatgccga ggaaaacgac gacgctgagc gcgatttccc acggtgagaa
    21901 gtcgacgctc gaggtgtcca gaccgagcca gccgggcagc aggtccaggt agaaccagcc
    21961 gagcaccccg aacatcagca cctggaagac cgagttcacc gcgaccagca ccgccgcggc
    22021 ctcgcgatca ccgcaggcga ggtcgttcca gatgatcacc atcgcgatgc accgggcgag
    22081 accgacgatg at
//
