LOCUS       NZ_LIWC01000001        22871 bp    DNA     linear   CON 28-MAR-2024
DEFINITION  Amycolatopsis sp. CB00013 scaffold1, whole genome shotgun sequence.
ACCESSION   NZ_LIWC01000001
VERSION     NZ_LIWC01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Amycolatopsis sp. CB00013
  ORGANISM  Amycolatopsis sp. CB00013
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 2203332)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2203332)
  AUTHORS   Yan,X., Ge,H., Hindra,F., Yang,D., Huang,T., Crnovcic,I. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-AUG-2015) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2014
            Assembly Method                   :: CLC Genomics Workbench v. 7.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905755.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:05:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,488
            CDSs (total)                      :: 8,430
            Genes (coding)                    :: 8,383
            CDSs (with protein)               :: 8,383
            Genes (RNA)                       :: 58
            rRNAs                             :: 1, 3, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (5S, 23S)
            partial rRNAs                     :: 3 (16S)
            tRNAs                             :: 50
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 47
            CDSs (without protein)            :: 47
            Pseudo Genes (ambiguous residues) :: 0 of 47
            Pseudo Genes (frameshifted)       :: 17 of 47
            Pseudo Genes (incomplete)         :: 38 of 47
            Pseudo Genes (internal stop)      :: 1 of 47
            Pseudo Genes (multiple problems)  :: 9 of 47
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:01:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1185647
            Orig. end                         :: 1208518
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LIWC01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22871
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="9"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22871
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22871
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12871](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12871
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    complement(306..321)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 19.52"
                     /tool="antismash"
     misc_feature    complement(317..332)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 19.52"
                     /tool="antismash"
     gene            397..1410
                     /locus_tag="AMK34_RS05250"
                     /old_locus_tag="AMK34_05210"
     CDS             397..1410
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007029603.1"
                     /locus_tag="AMK34_RS05250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_05210"
                     /product="hypothetical protein"
                     /protein_id="WP_073843317.1"
                     /transl_table=11
                     /translation="MGRLSAVSRIAIPLAGVLVLSSCSTDDTPNDSLQIVQNPVAATAA
                     VSPAVTVKPAGSVFAVPGVRALVTDEASKSLVVAVSEPPSLRIYDLAALDTPKTTVALP
                     GPAERLTVSGSQVLASVPGKSLLAKVSLPGGTLETVPVAGQPSAGLVDGDATLVSVRDR
                     KAVEVLSKNAGPRTITGQIYSADDVLNTGDGVVVLDKLRTALFAVDLAEGKIGEGLRAG
                     DGAANAVTDDLGRVFVTDARAGALLAFSTTPLLLRQRYPVPGGAYGIAYDRTRGLAWVT
                     LTERNEVVGFDVRGGEPIEKHRFPTVRQPDSVTVDEQGGRVVVGSAIGEGIQVITP"
     gene            1407..1628
                     /locus_tag="AMK34_RS05255"
                     /old_locus_tag="AMK34_05215"
     CDS             1407..1628
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007029602.1"
                     /locus_tag="AMK34_RS05255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_05215"
                     /product="DUF5703 family protein"
                     /protein_id="WP_016334446.1"
                     /transl_table=11
                     /translation="MTVVDEAVVEGDWEYRRLQLPPGVSRRAAATQLSIHAEFAGWELS
                     TVRLYSDGTRRVWLRRKRTATPLPGLIT"
     gene            complement(1798..2544)
                     /locus_tag="AMK34_RS05260"
                     /old_locus_tag="AMK34_05220"
     CDS             complement(1798..2544)
                     /NRPS_PKS="Domain: Polyketide_cyc2 (5-119). E-value:
                     2.5e-10. Score: 32.9. Matches aSDomain:
                     nrpspksdomains_AMK34_RS05260_Polyketide_cyc2.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334448.1"
                     /locus_tag="AMK34_RS05260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_05220"
                     /product="SRPBCC domain-containing protein"
                     /protein_id="WP_038513206.1"
                     /transl_table=11
                     /translation="MGHEFEITDRLEVDATPEQVWDAIATGPGITSWFMGRNEVDGGVG
                     GTVKTAFGGYEPTSAITSWDPLERLVYGTEPAPDGRFVAYEFLIEGRSGGSTVLRTVTS
                     GFLPGDDWEDEFEAMTAGGELFLRTLVEYLNRFAGRKAVPVTVFGPMIGDWDSAWLKLG
                     RELGLAGRPETGDRVRLSTDSVSTVEGEVYLANAQTVGIRTSDAFLRFVRGFAGPMVAM
                     HHLFGDVDPVEQDGIWAGWLGRVFKS"
     aSDomain        complement(2188..2529)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMK34_RS05260_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="2.50E-10"
                     /label="AMK34_RS05260_Polyketide_cyc2.1"
                     /locus_tag="AMK34_RS05260"
                     /protein_end="119"
                     /protein_start="5"
                     /score="32.9"
                     /tool="antismash"
                     /translation="EITDRLEVDATPEQVWDAIATGPGITSWFMGRNEVDGGVGGTVKT
                     AFGGYEPTSAITSWDPLERLVYGTEPAPDGRFVAYEFLIEGRSGGSTVLRTVTSGFLPG
                     DDWEDEFEAM"
     gene            complement(2545..3141)
                     /locus_tag="AMK34_RS05265"
                     /old_locus_tag="AMK34_05225"
     CDS             complement(2545..3141)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020635676.1"
                     /locus_tag="AMK34_RS05265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_05225"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_007029600.1"
                     /transl_table=11
                     /translation="MFSVAVIEDAEAAEVSLDPVRARLLAELAEPASATMLAARVDLPR
                     QKVNYHLRALEKHGLVELVEERRKGNVTERMMRATASSYVISPTALSAVQPDPAQSPDR
                     LSARWLLAVAGRLVRDVGLLITGATKARKRVATFAIDGEVRFSSAADRAAFAEELTVAI
                     TNLVSKYHDEGAEQGRDHRIVVAVHPSVRTEPEER"
     misc_feature    complement(3167..3180)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.32"
                     /tool="antismash"
     gene            complement(3182..4060)
                     /locus_tag="AMK34_RS05270"
                     /old_locus_tag="AMK34_05230"
     CDS             complement(3182..4060)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (24-273). E-value:
                     1.1e-25. Score: 82.7. Matches aSDomain:
                     nrpspksdomains_AMK34_RS05270_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334450.1"
                     /locus_tag="AMK34_RS05270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_05230"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_073843319.1"
                     /sec_met_domain="PF00561 (E-value: 5.6e-18, bitscore: 62.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 7.2e-22, bitscore:
                     75.9, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPGLLAADGTPLHFERWGDPSAPVTVVLLHGYALDRRSWRAIAPV
                     LAEAAEKPVAVLAYDQRGHGESGEVRAASATMGHLADDLAEVLEKVIPDGKVVLVGHDM
                     GGLAILSLAQRHPDVFAARVAGIGLLAMSAGGVTPDAIWPNALGKLGRDLEMVFGTKLI
                     GLVREHTSKAVTAGLRWWLFGDDPVPADVELTVRMIRGNWPQTVSAFRPALDAYTRESA
                     LSQVGAVPVIAIVGERDKLVPTADVEELAGAVQNGTSVVLPGVGHVVPLEAAPQVVPRL
                     LALANRAHRQD"
     aSDomain        complement(3242..3988)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMK34_RS05270_Abhydrolase_1.1"
                     /evalue="1.10E-25"
                     /label="AMK34_RS05270_Abhydrolase_1.1"
                     /locus_tag="AMK34_RS05270"
                     /protein_end="273"
                     /protein_start="24"
                     /score="82.7"
                     /tool="antismash"
                     /translation="TVVLLHGYALDRRSWRAIAPVLAEAAEKPVAVLAYDQRGHGESGE
                     VRAASATMGHLADDLAEVLEKVIPDGKVVLVGHDMGGLAILSLAQRHPDVFAARVAGIG
                     LLAMSAGGVTPDAIWPNALGKLGRDLEMVFGTKLIGLVREHTSKAVTAGLRWWLFGDDP
                     VPADVELTVRMIRGNWPQTVSAFRPALDAYTRESALSQVGAVPVIAIVGERDKLVPTAD
                     VEELAGAVQNGTSVVLPGVGHVVPLEA"
     gene            complement(4060..5382)
                     /locus_tag="AMK34_RS05275"
                     /old_locus_tag="AMK34_05235"
     CDS             complement(4060..5382)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1247: acetylornithine deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005164792.1"
                     /locus_tag="AMK34_RS05275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_05235"
                     /product="M20/M25/M40 family metallo-hydrolase"
                     /protein_id="WP_037338283.1"
                     /transl_table=11
                     /translation="MTEPNLIEAAAEEAVTLTSELIRIDTTNTGDPDTLVGERAAAEYV
                     AEKLTDAGYEITYVESGGKDRHNVIVRLPGADPSRGALLIHGHLDAVPADASEWSVHPF
                     SGAIQDDYVWGRGAVDMKDMCGMALALARHYKINGIVPPRDLVFAFLADEEAGGKYGAQ
                     WLVENRPELFEGVTEAISEVGGFSITLKDNVRAYLIETAEKGIRWMKLRVRGTAGHGSM
                     IHRDNAVTKLSEAVARLGNHRFPLVMTDSVREFLDGVTEITGWDFPEDDIEGSVAKLGN
                     ISRMIGATLRDTANPTMLTAGYKSNVIPSVAEASVDCRILPGRLEAFNAELEEILGPDI
                     EKEWMELPPVETTFDGALVDAMTNAVLAEDPGARTLPYMLSGGTDAKSFQSLGIRNFGF
                     APLQLPADLDFSALFHGVDERVPVDALKFGVRVLDRFLRSA"
     misc_feature    5584..5598
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 18.08"
                     /tool="antismash"
     misc_feature    5585..5597
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 18.9"
                     /tool="antismash"
     gene            5592..6701
                     /locus_tag="AMK34_RS05280"
                     /old_locus_tag="AMK34_05240"
     CDS             5592..6701
                     /EC_number="3.1.1.103"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020634765.1"
                     /locus_tag="AMK34_RS05280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_05240"
                     /product="serine hydrolase domain-containing protein"
                     /protein_id="WP_073843321.1"
                     /transl_table=11
                     /translation="MQRKLSRASLRIRLVAALTAAGLIATTGTALADADADRKVVQTAL
                     DQLTTTGGALGAQARVTDGHQRFTARSGKAELGSNRPVPENGRFRVGSITKTFVSTVLL
                     QLAGEGKLDLDVPVVRYLPGLIDGRITVRQVLQHTSGLYNYTDALPLDPAEFEKIRYKH
                     WTPQELLKISTGKPLDFEPGTRWSYSNTNYVVAGLLVERLTGRPYEKAVEQRILTPLRL
                     HDTEVPGDDVDISGPHAHGYVSVAGKPTDITRLNPSVAWAAGEIISTTRDLDTFGVALA
                     SGRLLKPAQQQEITKTTTVSPEYGLGLQVQTLPCGTRVWGHGGGIPGYSSQLLTTPDTR
                     KRLELSATSAPTGGDPNPAFVKLLTEVFC"
     gene            6701..7054
                     /locus_tag="AMK34_RS05285"
                     /old_locus_tag="AMK34_05245"
     CDS             6701..7054
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005166206.1"
                     /locus_tag="AMK34_RS05285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_05245"
                     /product="hypothetical protein"
                     /protein_id="WP_073843323.1"
                     /transl_table=11
                     /translation="MLHRSTGTIFIEDNVFSLGHRDDPRSPLHIAGAFPTPDTTGLLAT
                     APGFVAVELPPAPDGDFRVRDSVRHRDAGEDRGPNDPIEHHLIQIWPDTPHPDELLKAT
                     DKTGARWRDHRRR"
     gene            7174..7908
                     /locus_tag="AMK34_RS05290"
                     /old_locus_tag="AMK34_05250"
     CDS             7174..7908
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK34_RS05290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AMK34_05250"
                     /product="hypothetical protein"
                     /protein_id="WP_241832688.1"
                     /transl_table=11
                     /translation="MKGTVLGRSAGAVLLLFAAACSTPTTPPPSTPSSAPATTAPTSTT
                     PTVDLSSLRQGAVPAKYPEPDMSKLPPKPADSAPLRERIAWEALQKVTRFAHRLDPAAR
                     SSCPAFDPGRTTTATCTVTYLGEGYDYVLRDIKFQGTGLTNGRTEQGTVSYKADLTAGP
                     IIRDQVESVLRYQNSTEYTACDMPEHVRFGFDSTRRRPSGSSVVGEWIYMPGISCRYLD
                     SKARAVKAIPLELYDWGAPIHP"
     CDS             complement(8321..8464)
                     /gene="allorf_1193968_1194111"
                     /locus_tag="allorf_1193968_1194111"
                     /protein_id="allorf_1193968_1194111"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MCPFTGSQTRGADPRQQIGPRQSLCLERQTSHPSTWARCASRPEM
                     RS"
     CDS_motif       complement(8363..8464)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MCPFTGSQTRGADPRQQIGPRQSLCLERQTSHPS"
                     /locus_tag="allorf_1193968_1194111_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(8321..8362)
                     /prepeptide="core"
                     /locus_tag="allorf_1193968_1194111_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.90"
                     /molecular_weight="1496.7"
                     /monoisotopic_mass="1495.7"
                     /core_sequence="TWARCASRPEMRS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MCPFTGSQTRGADPRQQIGPRQSLCLERQTSHPS"
                     /leader_location="[8362:8464](-)"
                     /alternative_weights="1514.7"
                     /alternative_weights="1532.7"
     gene            complement(8513..9745)
                     /locus_tag="AMK34_RS05295"
                     /old_locus_tag="AMK34_05255"
     CDS             complement(8513..9745)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334464.1"
                     /locus_tag="AMK34_RS05295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_05255"
                     /product="acetyl-CoA hydrolase/transferase C-terminal
                     domain-containing protein"
                     /protein_id="WP_038513198.1"
                     /transl_table=11
                     /translation="MRVLSESQLGSVLAGVPASRPRVVVSGNFATPMRALKVLDAALAE
                     YRLFALNAQAGMPDREGVLLETPFVGAGMRGRPGLRYFPSRLSLVPQLLKHSLPPDVVL
                     LHTSAPVDGVVSLGTEVNILPAAIEAVRARGGLVIAQLNPEMPFTYGDGLVPVDEIDYG
                     IEVVEPLLSPVPRPVGDTARTIGERVAGLVEDGATLQLGIGGIPDATLAAVTGRRGLAI
                     WSEMFSDGVLALDRAGALDPAEPVTASFVFGSADLYRWLDRNPRIRLLRTEKTNDPAVI
                     ARQRGLVSVNSALEVDLYAQANASRVRGAIYSGFGGQTDFVVGALHSPGGRAIIALPSW
                     HPKADVSTVVPRLTGPVTSFQHSFVVSEHGVATIWGNDASEQARQIVDQVAHPSAREEL
                     IARGRDLGFAL"
     gene            10001..12871
                     /locus_tag="AMK34_RS05300"
                     /old_locus_tag="AMK34_05260"
     CDS             10001..12871
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007029581.1"
                     /locus_tag="AMK34_RS05300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_05260"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_073843327.1"
                     /sec_met_domain="DUF4135 (E-value: 4.3e-100, bitscore:
                     332.4, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 7.6e-14, bitscore:
                     48.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPPPSATSLPPRWWEHGRTPRERTADKPLWADFAEHAVTTLLPE
                     RPPVGDWRVRFAGVFRSLVDAASRDAVPDDLPGADVDALRRGFAAQLDQHLLNLSVRTL
                     VLELHRARKAGALQGETPEERFSDFVRRQSTPAGLVRLFGEYPVLARLLAQACLYAAEA
                     HAETLARFSADAALLPCSVIDGELGTLVEVAGGFGDSHARGRSVKLLRFSSGAKVIYKP
                     RSLILHERFTDVVEQLNKRLPGLELRTADALTRDGYGWLRFVEHQPCADLGDVDRFYRR
                     QGILLALLHALDATDVHYENIIACGDQPVLIDIETLFQPSPPVPPEGDPAAAMLARSVQ
                     RTLLLPQLFAGEHGAVDISGLAGRGGKLPTDRVDWADAGTDRMRLARVPGELAGSNNLP
                     RLDGRDVAPAEHSAALLAGFRLGYDAISTGRDELAELLRRCAEDPIRVLIRPTNFYSRL
                     LDETTHPDLLRDAADRDHAFDLLEEDSVREEKLLRLVPHERDDLWAGDVPMFTSNPGST
                     SLLDSRGDSVEGVVEQPSLDTVLAKVADMDPLDQRDQEWLISATLAISTAADGHHGGGE
                     TAETAVPNQAPDAERLLVTACGIADQIVANAFSDEHRSNWLGIELVDDRYWTVLPMGAG
                     LGEGYCGVALFLAQLAELTGIARYRDLAAYAISPLPGLFATLRADRELAATAGCGGLLG
                     LGGVAYTIARLSTLVGLPAGDLIEQAVELMPEATSETPSGFTTGLAGGVASMRSVYVQT
                     GLETALARADRYAAQLLERERPSEKAFARGSAGIDWVLRAHDRPGEEPPGKADDRAEST
                     GGWCDGLAGDALGMAAHLPDPEHARDLDRTIRRLTDGAPLKDLSLCHGESGVLDVLCVL
                     AENGHTGAAAAVRRRTGHLLAAIDQRGARCGTPGAVPSPGLLSGLAGIGYGLLRLGFGD
                     RVPSALLLRPDRPHPAATVFPPVNRV"
     gene            12885..13079
                     /locus_tag="AMK34_RS05305"
                     /old_locus_tag="AMK34_05265"
     CDS             12885..13079
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007029580.1"
                     /locus_tag="AMK34_RS05305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_05265"
                     /product="hypothetical protein"
                     /protein_id="WP_016334466.1"
                     /transl_table=11
                     /translation="MYERDLPATEDVLGAVNLPRALEVGSRNHALAGSKPRLSANPLAT
                     LSTDTGSPSVVSVFTGGWI"
     gene            13170..16058
                     /locus_tag="AMK34_RS05310"
                     /old_locus_tag="AMK34_05270"
     CDS             13170..16058
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007029579.1"
                     /locus_tag="AMK34_RS05310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_05270"
                     /product="LuxR family transcriptional regulator"
                     /protein_id="WP_073843329.1"
                     /transl_table=11
                     /translation="MGIRSSRVIGRDAELAELSGALDRAIAGRGGAIFLVGEGGIGKSR
                     LAVEAASRAVAADIPVLQGRASSIGPLVPFRPLTQALLSHFRGGGPPEATELDPFIPVL
                     AQLIPDWSRGDRPRESGSLLVLAEAVFRLLAVTSRDRGALLVLDDLQDADAETLFILEY
                     LVDNLPAAQTLFVGTLRNEPSDALRLATSGAQRMSCTIAELGRLGLADTHALAAACLET
                     EPGQLPSAATELLWRNSAGLPFIVEELLHGMVNDGLLVEGRDGWRVIGELRARVPAALV
                     TSIGARMEQLGEQAGELLSVAAIIGRRFPLTVVQKVTGTNDRTLHNHLGAAVSANLVTT
                     DEMTPGWYAFRHPLTAEALLARQSPARKAELARQTADAVEELYPGLPGDLCALVASLRL
                     TALDERAAGRLFAETGRRALDAGAADSAVTMLTKALDLLAGADAGDRAEVLETLVHALG
                     QTGQFDRAVELSAAFGEIGTLERAAKLRTQLAWAAYIAGRHDECLGQIERARAPLGSAI
                     TPAQQAALDAVEANLWLDVPGKTGTAERLARQAWKVAEATEQPFVVCQALQVLGMLALS
                     RDLSESEHYMQLARRTAEDNHLHHLRTQALVRLGGHRVLMNGDEQTLLLARADAQRTGS
                     ITLHCAVDSVRTMHAILRCDFGTAHTLLAENLAVLGRLRLTALLQYAHMTRAMSAGHRA
                     DRPAMEQALDDFRESGGENAQEMVLSIGLARVFCSLLEEDFDRARRELGQVIELEDRRP
                     SRFHLAGQHGLRTLVDTLGGAPCPEDGSAVSGMRWNRQFVEFARAVEHGRRGDAAEAER
                     AVASALETSAPYPLARHLGLRLIAEPAAADGWGDPAGWLKEAEEYFHGRDIQAVAAACR
                     TLLRKLGAPVRQRRSGVDRVPGGLRAAGVTVREYEVLVLLAERMGNKDIGARLHISPRT
                     VEKHVASLLAKTGLADRAALAEHAAGPRPGML"
     gene            16062..16301
                     /locus_tag="AMK34_RS05315"
                     /old_locus_tag="AMK34_05275"
     CDS             16062..16301
                     /GO_function="GO:0015035 - protein-disulfide reductase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334468.1"
                     /locus_tag="AMK34_RS05315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_05275"
                     /product="glutaredoxin domain-containing protein"
                     /protein_id="WP_073843331.1"
                     /transl_table=11
                     /translation="MSDLTVYGAGWCPDVKRSRALLDSKGVEYDYIDVEADSGAEETVR
                     ALQNGERRIPTIVWPDGTHLVEPSDDELTAHLNR"
     CDS_motif       16062..16088
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSDLTVYGA"
                     /locus_tag="AMK34_RS05315_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       16089..16301
                     /prepeptide="core"
                     /locus_tag="AMK34_RS05315_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-1.90"
                     /molecular_weight="7719.4"
                     /monoisotopic_mass="7714.9"
                     /core_sequence="GWCPDVKRSRALLDSKGVEYDYIDVEADSGAEETVRALQNGER
                     RIPTIVWPDGTHLVEPSDDELTAHLNR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSDLTVYGA"
                     /leader_location="[16061:16088](+)"
                     /alternative_weights="7737.4"
                     /alternative_weights="7755.4"
                     /alternative_weights="7773.4"
                     /alternative_weights="7791.4"
                     /alternative_weights="7809.5"
                     /alternative_weights="7827.5"
                     /alternative_weights="7845.5"
     gene            16298..16513
                     /locus_tag="AMK34_RS05320"
                     /old_locus_tag="AMK34_05280"
     CDS             16298..16513
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334469.1"
                     /locus_tag="AMK34_RS05320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_05280"
                     /product="hypothetical protein"
                     /protein_id="WP_038513192.1"
                     /transl_table=11
                     /translation="MTLPDVPVGTRVVVRYRIEGGFTDALGYLRSRDDTECTVETKRGL
                     ATIRLADIVLAKTVPPPPTPRTPRER"
     gene            complement(16732..17613)
                     /locus_tag="AMK34_RS05325"
                     /old_locus_tag="AMK34_05285"
     CDS             complement(16732..17613)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334470.1"
                     /locus_tag="AMK34_RS05325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_05285"
                     /product="manganese catalase family protein"
                     /protein_id="WP_073843333.1"
                     /transl_table=11
                     /translation="MFRHTKSLQFEAKPEKPDALYARKLQELIGGAYGEMTVTMQYLFQ
                     GWNCRIEGKYKDLIMDTATEEIGHVEMLATMVARLLEGAPATTVAEAAKDPATAAILGG
                     MDPQQAIISGGGATPSDSQGYPWNGRYVVASGNLLADFRANAAAEAQGRLQTARLYNMT
                     DDPGVKAMLQFNLARDTVHQKQWLAAIEELKADGLESDIAPTALFDEENQDHNNTVWHL
                     SDGPDGAKGGWSFGEDGIEYLMDPEPLGGPGTAPKPDPALFGTYAPLQDAVGTVKGKAK
                     DAKKKATKSRKS"
     gene            complement(17645..18100)
                     /locus_tag="AMK34_RS05330"
                     /old_locus_tag="AMK34_05290"
     CDS             complement(17645..18100)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334471.1"
                     /locus_tag="AMK34_RS05330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_05290"
                     /product="DUF4383 domain-containing protein"
                     /protein_id="WP_038513188.1"
                     /transl_table=11
                     /translation="MTASPATVRRAPRQLIALGVGAVFLLVGILGFIPGVTTNYEQLSG
                     AGHESGALLLGVFQVSILHNIVHLAFGVAGILLARTASGAKAFLVGGGVVYLVLWLYGL
                     LIDHGSAANFVPVNSADNWLHLGLAVGMIALGLIPLSGSKAPIADSR"
     gene            18267..18935
                     /locus_tag="AMK34_RS05335"
                     /old_locus_tag="AMK34_05295"
     CDS             18267..18935
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334472.1"
                     /locus_tag="AMK34_RS05335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_05295"
                     /product="hypothetical protein"
                     /protein_id="WP_073843335.1"
                     /transl_table=11
                     /translation="MAEHEAPQAGPVGRLFRAGFHSLSALRGARAFHPNGLLLKGELHA
                     LRRDDLALPPEPVTVTVRMSKGAGLPGRIPDALGLAIRVPTADGDPWDLTLTTSAVRVV
                     PRPARSWTTGRFSSLLPYRVNGELVWLSARAETPRRAEASLDALSRLVQEGPVTYLVET
                     VRANGHRKPCATLTLHEVDQDASRPAFDPMLNAPPGWELRPRWLTGLRERAYEGSREGR
                     "
     gene            complement(18937..20244)
                     /locus_tag="AMK34_RS05340"
                     /old_locus_tag="AMK34_05300"
     CDS             complement(18937..20244)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334473.1"
                     /locus_tag="AMK34_RS05340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_05300"
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_073843337.1"
                     /sec_met_domain="Aldedh (E-value: 3.1e-81, bitscore: 270.1,
                     seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISSDAPAVVEELRTLFRSGVTKPVEWRRTQLTGLRTLLSEQADV
                     FLKALYADLRKNTAEAKRAEIALVRNEIDHTLENLDSWLSPEPAGLPYPLRPADGRVVR
                     EPLGVALIIGPWNYPLQLVLAPLVGALAAGNCAVVKPSELSPNTSAAIAEHLPNYVEGV
                     RVVEGAIPETTALLEQKFDTIFYTGNGTVGRIVMAAAAKHLTPVTLELGGKSPAIVEPG
                     ADLAVTAQRLAYGKFANAGQTCVAPDYVLAIGDTGPKLAEHLAEAVRAMFGDDPATSEA
                     YGRIISTRHHDRLAALLDNGTAVVGGQTDRDEKYIAPTVLTDVSPDAPVMRDEIFGPIL
                     PIIDVPDVNAALAFVNERDKPLALYAFTESEETKRRIETETSSGGLVFGAAIIHLAAPE
                     LPFGGVGESGMGRYHGRYSIENFSHVKAVLDKPIAG"
     CDS             complement(20325..20462)
                     /gene="allorf_1205972_1206109"
                     /locus_tag="allorf_1205972_1206109"
                     /protein_id="allorf_1205972_1206109"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MSTVKYMKAPFLALDARKGAFMYLGKVVKEVERPECGLQSRESRP
                     "
     CDS_motif       complement(20403..20462)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSTVKYMKAPFLALDARKGA"
                     /locus_tag="allorf_1205972_1206109_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(20325..20402)
                     /prepeptide="core"
                     /locus_tag="allorf_1205972_1206109_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.60"
                     /molecular_weight="2902.3"
                     /monoisotopic_mass="2900.5"
                     /core_sequence="FMYLGKVVKEVERPECGLQSRESRP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSTVKYMKAPFLALDARKGA"
                     /leader_location="[20402:20462](-)"
                     /alternative_weights="2920.4"
     misc_feature    20394..20405
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     misc_feature    complement(20437..20448)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     gene            complement(20478..22811)
                     /locus_tag="AMK34_RS05345"
                     /old_locus_tag="AMK34_05305"
     CDS             complement(20478..22811)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334474.1"
                     /locus_tag="AMK34_RS05345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK34_05305"
                     /product="chitobiase/beta-hexosaminidase C-terminal
                     domain-containing protein"
                     /protein_id="WP_073843339.1"
                     /transl_table=11
                     /translation="MNRIFVQPERRKGFRGALALGLSALLIAAGLGGATAAAADYSQSA
                     ASLNATQAQFSFTPASPARYVDIHYTGVPGVGQQNVRMTDNGGTWRHTVGSLSAGTVLD
                     YWFTYEKSGPQYDTPHFTYTHGGSGTTVASPTFDPPGGSYPSARSVTLSSATSGATIRY
                     TVDGSTPTASSTLYTGPITVSASSTISAIALKSGSANSPVASASYTIGSTQATCPVQAE
                     VPDFGPNVRIFDPGMSAASIQSRLDADFNAQKDTLTAQFTERRYAHLFKPGVYNGIHDN
                     VGYYTSVAGLGQNPGDVVINGDVTVDAFNESDKGVALQNFWRSAENLAVVPSSGSTRWA
                     VAQAAPFRRMDIRGGLQLYPASYGFASGGYTADTKVSGQAASISQQQWYTRDSSYGSWD
                     GGVWNMVFSGTSGAPANTFPNPPETTLGTTPVSRDVPYLYLDGSGKYRVFLPSLRTNAS
                     GPSWANGGTQGSSLPMSQFYVVKAGDTASSINTALSQGCNLFFTPGVYHLNQTLNVTKA
                     NTVVLGVGYPTLVPDNGVDAMKVADVDGVRLKGLLFDAGTTNSQSLLTVGQAGSTTNHA
                     ANPTTLQDVFFRIGGQIAGKATNSLIVNSRDTIIDHIWAWRADHGNAGTYGWTINTGDT
                     GVVVNGDNVLATGLFVEHYQKYQVIWNGQNGRTIFFQNEIPYDVPDQAGWKSPNGLNGY
                     AAYKVGDNVTTHEAWGLGSYCFFNDNPSVNLYHAFEVPNRSGVRFHNLVTVSLNYKGTI
                     THVINDAGAVTPPDTRPSNLVSYP"
ORIGIN
        1 cgttttcgcg ggctatgtcg aacatcaccg gaccgatcgc gcggccagga tcgtgcaggc
       61 ggtcgcgacg gccgccgacg gcctcggcac ctcgccgctg gcggtcgcgc tggcctgggt
      121 ccgcgaccgg cccggagtgg tcgcgcccgt ggtcggagcc cgtgacaccg gtcagctgac
      181 cggctcgctc accgccgagg acatcacgct cccgcccgcc atccgctcgg cgctcgacga
      241 cgtcagcgcg atcgaggtcg ggtacccgga acgcggcctc tgagccgtct cgaatactgg
      301 attaggtgac tgttgggtga cgctgacgtg acgtggtgga gttccaggag gatgctggac
      361 aagtccgttc gacgaatagc aggtggaggc accaaggtgg gtcggctgtc cgccgtttcc
      421 cggatcgcga tcccgctcgc cggtgtcctg gtgctctcgt cctgcagtac ggacgacacg
      481 ccgaacgact ccttgcagat cgtgcagaac cccgtcgcgg cgacggcggc ggtctctccc
      541 gccgtgaccg tcaaacccgc cggttcggtg ttcgcggtgc cgggggtgcg ggccctggtg
      601 accgacgagg cgagcaagtc gctggtcgtc gccgtttcgg agccgccgtc gctgcgtatc
      661 tacgatctcg ccgccttgga caccccgaag acgacagtgg ccctgcccgg tcctgccgag
      721 cgcctgacgg tctcgggctc ccaagtgctc gccagcgttc ccggcaagag tctcctggca
      781 aaggtctccc tgcccggtgg cacgctggag acggtcccgg tcgcggggca gccgtcggcc
      841 ggccttgtcg acggcgacgc gacgctggtg tccgtccggg accgcaaggc cgtcgaggtg
      901 ctgtcgaaga acgcgggacc gaggaccatc accggccaga tctacagcgc cgacgacgtg
      961 ctgaacaccg gtgacggcgt ggtcgtgctc gacaagctcc gcaccgccct gttcgccgtc
     1021 gacctcgccg agggcaagat cggcgagggc ctgcgcgccg gcgacggcgc ggctaacgcc
     1081 gtcaccgacg atctcggccg cgtcttcgtc accgacgcgc gcgcgggcgc tctgctggcg
     1141 ttctccacga cgccgctgct gttgcgccag cgctatcccg tgcccggcgg ggcgtacggc
     1201 atcgcctacg accgcacgcg cggcctcgcc tgggtcacgc tcaccgaacg caacgaggtc
     1261 gtcggtttcg acgtccgcgg tggagagccg atcgagaagc accggttccc caccgtgcgg
     1321 cagccagatt cggtcaccgt cgacgagcag ggcggccgtg tggtcgtcgg ctcggccatc
     1381 ggagaaggga tccaggtgat cacgccatga cagtggtgga cgaggcggtg gtcgaagggg
     1441 attgggagta ccggcggctg cagctgcctc ctggtgtttc ccggcgggcg gcggcgacgc
     1501 agctgtcgat ccacgccgag ttcgccggct gggagctttc gaccgtccgg ctctactcgg
     1561 acgggacccg gagggtgtgg ttgcgccgga agcgcaccgc tacgccgctg cccggcctca
     1621 tcacctgaga agcagccgat gttgtgggcc ctcccgaccg gctccgtgcc gtcgggtggt
     1681 cgctgtagta cgtgaaggcc cccttcattg cgtctagcgc agtgaagggg gccttcacgt
     1741 acttggcacg cgcgacgaaa gcgtccttca ccgcacgaga tgcggcgaaa ggccccttca
     1801 gctcttgaag acccggccca gccagccggc ccagatcccg tcctgttcca caggatcgac
     1861 atcgccgaac aggtgatgca tcgcgaccat cggcccggcg aacccgcgca cgaagcgcag
     1921 gaaagcgtcc gaggtccgga tgccgaccgt ctgcgcgttc gcgagataga cctcgccctc
     1981 cacagtggac accgagtcgg tggaaagccg tacccggtcc cccgtttccg gccgccccgc
     2041 gaggccgagt tcccggccca gcttcagcca cgcgctgtcc cagtccccga tcatcggccc
     2101 gaacaccgtc accggcacgg ccttccggcc cgcgaaccgg ttgaggtatt cgacgagggt
     2161 gcggaggaac agctcgccac ccgcggtcat cgcctcgaac tcgtcttccc agtcgtcgcc
     2221 gggcaggaag ccgctcgtca cggtccgcag cacggtgctg ccgccggagc ggccctcgat
     2281 gaggaactcg tacgcgacga accgtccgtc cggcgcgggt tccgtgccgt agacgagccg
     2341 ctccagcggg tcccacgacg tgatcgccga cgtgggttcg tagccgccga acgcggtctt
     2401 cacggttccg ccgacgccgc catcgacctc gttgcggccc atgaaccacg acgtgatccc
     2461 cggtccggtc gcgatggcgt cccagacctg ttcgggcgtc gcgtcgacct cgaggcggtc
     2521 ggtgatctcg aattcgtggc ccactcagcg ctcctcgggc tcggttctga cactcggatg
     2581 gacggcgacg acgatccggt gatcgcggcc ctgttcggcg ccctcgtcgt ggtatttgct
     2641 caccagattc gtgatcgcga cggtgagctc ttcggcgaac gcggcccggt ccgcagcaga
     2701 ggagaaccgc acctcgccgt cgatcgcgaa ggtcgcgacc cgcttgcgcg ccttggtcgc
     2761 accggtgatc agcaagccga cgtcgcgcac gagccttccg gccaccgcga gcagccagcg
     2821 tgcggacagc cggtccggtg actgcgccgg atcgggctgc acggccgaga gcgccgtcgg
     2881 tgagatgacg tacgaggacg ccgtcgcgcg catcatgcgc tcggtgacgt tgcccttccg
     2941 ccgctcctcg acgagctcga ccagcccgtg cttctccagt gcgcgaaggt ggtagttcac
     3001 cttctgtctc ggcaggtcca cccgcgcggc cagcatcgtg gccgacgccg gctcggcgag
     3061 ttcggcgagc agcctggccc ggaccggatc cagcgacact tcggccgctt ccgcgtcctc
     3121 gatcaccgca acggagaaca tgccaagaag gtgtcaccga aaagagtttt tgtcaagaag
     3181 gtcagtcttg tcggtgcgcc cggttcgcga gtgccagcaa gcggggcacc acctgcgggg
     3241 ccgcctcgag cgggacgacg tgcccgaccc cggggagcac cacggacgtg ccgttctgca
     3301 ccgcaccggc cagctcctcg acgtccgccg tcggcacgag cttgtcgcgc tcccccacga
     3361 tcgcgatcac cggcaccgcg ccgacctgcg acaacgcgga ttcccgcgtg taggcgtcca
     3421 gcgctggtcg aaacgccgat accgtctgcg gccagttgcc gcggatcatc cgcaccgtca
     3481 gttcgacgtc ggcgggcacc gggtcgtccc cgaagagcca ccaccgcagc ccggcggtca
     3541 ccgccttgct cgtgtgctca cgcaccaggc cgatgagttt ggtcccgaag accatctcca
     3601 ggtcgcggcc gagtttcccg agcgcgttcg gccagatcgc gtccggcgtg acaccgcccg
     3661 ccgacatggc gagcaacccg attcccgcca ctcgcgccgc gaagacgtcc gggtggcgct
     3721 gggcgagcga caggatcgcg agcccgccca tgtcgtggcc gaccaggacg accttgccgt
     3781 cggggatcac cttctccagc acctcggcca gatcgtcggc gaggtgtccc atcgtcgccg
     3841 acgcggcccg gacctcgccc gattcgccgt gcccgcgctg gtcgtaggcg agcaccgcga
     3901 ccggcttctc cgcggcttcc gccagcaccg gcgcgatggc gcgccagctt cgcctgtcga
     3961 gggcgtaccc gtggaggagg acgacggtca ccggcgccga cggatcaccc cagcgttcga
     4021 aatgcagggg tgtcccgtcg gcggccagca gaccgggcat caggccgaac ggaggaagcg
     4081 gtcgagcacg cgcacgccga acttcagcgc gtcgaccggg acgcgctcgt cgactccgtg
     4141 gaacagcgcc gagaaatcga ggtccgcggg cagctgcagc ggggcgaacc cgaagttgcg
     4201 gatcccgagc gactggaagg acttcgcgtc ggtgccgccg gagagcatgt acgggagcgt
     4261 gcgggcgcca gggtcctcgg cgaggaccgc gttggtcatg gcgtcgacca gggcaccgtc
     4321 gaaggtcgtc tcgaccggcg gcagctccat ccactccttc tcgatgtccg gaccgaggat
     4381 ctcctccagc tcggcgttga acgcctcgag acggccggga aggatccggc agtcgaccga
     4441 agcctccgcg accgagggga tgacgttcga cttgtagccc gccgtgagca tcgtcgggtt
     4501 cgccgtgtca cgcagggtcg cgccgatcat ccgggagatg ttgccgagtt tcgcgacgga
     4561 accctcgatg tcgtcctcgg ggaagtccca accggtgatc tcggtgacgc cgtccaggaa
     4621 ctcgcggacg gagtcggtca tgaccagggg gaaacggtgg ttgccgagcc tggcgacggc
     4681 ctcggacagc ttggtgacgg cgttgtcgcg gtggatcatc gagccgtgac cggctgtgcc
     4741 gcgcacgcgc agcttcatcc agcggatgcc cttttcggcc gtctcgatga ggtacgcgcg
     4801 gacgttgtcc ttcagcgtga tcgagaagcc gccgacctcg ctgatcgcct cggtgacgcc
     4861 ctcgaacagc tccggccggt tctcgaccag ccactgcgcg ccgtactttc cgcctgcttc
     4921 ttcgtcggcc aggaacgcga agacgaggtc acgcggcggg acgatgccgt tgatcttgta
     4981 gtgacgggcc agcgcgagcg ccatcccgca catgtccttc atgtcgaccg cgccgcggcc
     5041 ccagacgtag tcgtcctgga tcgcgccgga gaacgggtgc accgaccact ccgaggcgtc
     5101 ggcggggacg gcgtcgaggt gaccgtggat caggagcgcg ccgcgcgagg ggtcggcgcc
     5161 cggcagccgg acgatcacgt tgtggcggtc cttgccgccg gactcgacat aggtgatctc
     5221 gtagcccgcg tcggtgagct tctcggcgac gtactcggcc gcggcgcgtt caccgaccag
     5281 cgtgtcgggg tcaccggtgt tggtggtgtc gatgcggatc agttcactgg tgagggtgac
     5341 tgcctcttcg gctgctgctt cgatcaaatt cggttcggtc accaggcatt cctaccattg
     5401 gtggagcccg ccgacccgtt gccaccgcgt ggtggacgtc gtgtgacggc ccactccccc
     5461 gcgtgccccg gccatctgct ctcttcgagt ggttgtgatt tcaggtactg cgggtggcga
     5521 acgccggccg ctagcgtcgg ctcacgtcgt tcggggagag ccttcgggct tctaaggggg
     5581 attttcgcat catgcaaaga aaactctcgc gggcttcgct gagaatccgg ctcgtcgccg
     5641 cgctcaccgc ggccggtctg atcgccacca cgggcaccgc gctggccgac gccgacgccg
     5701 atcgcaaggt cgtgcagacg gcgctggacc agctcaccac gactggagga gcgctcggcg
     5761 cgcaggccag ggtgaccgat ggtcaccagc gtttcaccgc gcgctccggc aaggcggaac
     5821 tgggttcgaa ccggccggtc ccggagaacg gccggttccg cgtcggcagc atcaccaaga
     5881 cgttcgtatc gacggtgctg ctgcaactcg ccggcgaggg caagctcgac ctggacgtgc
     5941 cggtcgtccg ctacctgccc ggcctgatcg acggccgcat caccgtgcgc caggtcctgc
     6001 agcacacgag cggcctctac aactacaccg acgcgttgcc gctcgaccca gccgagttcg
     6061 agaagatccg ctacaagcac tggacaccgc aggaactgct caagatctcg accggcaagc
     6121 cgctcgactt cgagcccgga acccggtgga gctactccaa caccaactac gtggtcgcgg
     6181 gtctgctggt ggaacgattg accggcaggc cgtacgaaaa ggcggtcgag caacggattt
     6241 tgacgccgtt gcgcctccac gacaccgagg ttcccggcga cgacgtcgac atcagcggcc
     6301 cgcacgccca cggctacgtg tccgtggcgg gcaagccgac cgacatcacc cgcctcaacc
     6361 cttcggtcgc gtgggccgcg ggcgagatca tctcgacgac ccgtgatctg gacaccttcg
     6421 gcgtggccct ggcgagcggc aggctgctca aacccgcaca acagcaggag atcaccaaga
     6481 ccacgacggt cagccccgaa tacggtctcg gcctgcaggt gcagaccctg ccgtgcggta
     6541 cccgggtgtg gggccacggc ggcggtatcc ccggctattc ctcgcagctg ctgaccaccc
     6601 cggacacccg gaagcggctg gagctttcgg ccacgagcgc gccgaccgga ggcgatccga
     6661 acccggcgtt cgtcaagctg ctcaccgagg tcttctgctg atgctccacc ggtccacggg
     6721 cacgattttc atcgaggaca acgttttctc cctcgggcac cgcgacgacc cgcgaagccc
     6781 tctgcacatc gccggagcct tccccacccc cgacaccacg ggattgctcg ccacggcgcc
     6841 gggtttcgtc gcggtcgagc tgccaccggc tccggacggc gactttcgag tacgggactc
     6901 agtacgccac cgcgacgccg gtgaagaccg cggaccgaac gacccgatcg aacatcacct
     6961 gatccaaatc tggccggaca caccacaccc cgacgaactg ctgaaggcca ccgacaaaac
     7021 cggcgcacgc tggcgcgatc accgacgccg atgaacgaat tcaccgggaa cggcattttt
     7081 acgctcatga cccggctgct tcgccgctag ttttcttccc gaagggaccg ggggaactgg
     7141 tcatcgaatc agcgagatcg gagatgaccc ggcgtgaaag gcaccgtcct cgggcgctcg
     7201 gcgggggcgg tattgctcct gttcgcggcg gcctgcagta ctcccacgac tcccccgccc
     7261 agcactccat cgtcggctcc ggcgaccacc gcacccacga gtacgacgcc gacggtcgat
     7321 ctttcgtccc tgcgtcaagg cgcggtcccg gcgaagtacc ccgagccgga tatgagcaag
     7381 ttgccaccca agcccgcgga ctccgcaccg ctgcgggagc ggatcgcctg ggaagcactg
     7441 caaaaagtga ccagattcgc gcatcgcctc gaccccgcgg cgcgctcgtc ctgccccgcg
     7501 ttcgaccccg gccgcaccac cacggcgacc tgcacggtca cctatctcgg tgagggttac
     7561 gactacgtgc tgcgcgacat caagttccag ggcaccgggc tgaccaacgg ccgcaccgaa
     7621 caaggaaccg tctcctacaa ggcggacctc accgccgggc cgatcatccg cgaccaggtc
     7681 gagtcggtgc tgcgctatca gaacagcacc gaatacacgg cctgtgacat gcccgagcac
     7741 gtgcgcttcg gattcgactc cacccggcga cggccatccg ggtcgtcagt cgtcggcgag
     7801 tggatctaca tgcccggcat ctcgtgccgc tacctcgatt ccaaggcccg agcggtcaag
     7861 gccattccct tggagctcta cgactggggc gcgcccatcc atccgtgacg agttacgcct
     7921 ccaatcacgc gagatcggcc accccgccca gattccccct gggtccgtca cccgtaccgg
     7981 tgattctcgc cgactcacca ttcgtggcat gtggatcacc ggttcgtgtc accccgccgc
     8041 ccacttgccg tagcggaggc tcggcgtcca catcggcgca ccgcaacccc gctacacacg
     8101 gtgtcagcgc ccgcgaaacc cacccctggc ctaaaacacg aaagacttac atgtttatcg
     8161 taggaagatt cacgacccgc cgaacgcccg ggaaatcgtt ttttgacagg tcgccaacgt
     8221 ggtgaaaatc ttcgatcgct cctcgcgaga gcacaaccga acacgaaatc cgaacaagga
     8281 gcccctcaat gcagatgttc acccagcacg tgcaccacgg tcacgacctc atttcgggtc
     8341 tgctcgcgca cctggcccac gtgctcggat ggctggtctg acgctctaag cacagggatt
     8401 gacgggggcc aatctgttgg cgcgggtcgg cccctcgtgt ttgcgacccg gtaaagggac
     8461 acattcgtgt ccctttaccg ggttccggtt tttcgagccg aaagaaatac cgctaaagcg
     8521 cgaatcccag gtccctgccc cgcgcgatga gttcttcccg agccgaggga tgcgcgacct
     8581 ggtcgacgat ctgccgcgcc tgctcgctcg cgtcgttgcc ccagatggtc gcgacaccgt
     8641 gctcactgac cacgaaactg tgctggaacg acgtcaccgg accggtcagc cggggcacga
     8701 ccgtcgaaac gtcggccttc ggatgccacg acggcagcgc gatgatcgcc cggccaccgg
     8761 gtgaatgcaa cgccccgacc acgaagtcgg tctgcccgcc gaaccccgag tagatcgccc
     8821 ctctcacccg gctcgcgttg gcctgtgcgt acaggtcgac ttcgagggcg ctgttcaccg
     8881 agaccagacc tcgctggcgg gcgatcacgg cgggatcgtt cgtcttttcc gtacgcagca
     8941 aacggatccg cggattgcgg tcgagccagc ggtacaggtc cgcactgccg aacacgaacg
     9001 acgccgtcac cggttccgcc ggatcgaggg cccccgctcg atcgagcgcg agcacgccgt
     9061 cgctgaacat ctccgaccag atcgcgagcc cgcgccgtcc ggtcaccgcc gccagggtcg
     9121 cgtcggggat cccgccgatg cccagttgca gggtcgcgcc gtcctcgacc aacccggcca
     9181 cccgctcacc gatggtccgc gccgtgtccc ccaccggccg cgggaccggc gacagcagcg
     9241 gttccaccac ctcgatgccg tagtcgatct cgtcgaccgg cacgaggccg tcgccatagg
     9301 tgaacggcat ctcggggttg agctgcgcga tgaccaggcc gccgcgggcc cgcaccgcct
     9361 cgatggcggc cggcaggatg ttcacctccg tgcccagcga caccacgccg tccaccgggg
     9421 ccgaggtgtg cagcaggacg acgtccggcg gcagcgagtg cttgagcagc tgtggcacca
     9481 gcgaaagccg ggacgggaag taccgcagcc cggggcggcc gcgcataccc gcgcccacga
     9541 acggcgtttc cagcaggaca ccctcacggt ccggcatgcc ggcctgcgcg ttcaacgcga
     9601 acaagcggta ctccgccagt gccgcgtcca gcaccttcag cgcccgcatc ggcgtggcga
     9661 agttcccgct caccaccact cgcggccgcg aggcgggcac gcccgcgaga acggaaccga
     9721 gctggctctc cgacaagacg cgcatgagcc gatcatgccc gaggagcccc tcgccggcgc
     9781 gggccggacc cccagaaacc ggcccgcgcc ggccccgccc gaccatggtg cgaccgggac
     9841 cggtgcccgc gcatgggtgc cgggacccca tattccggtg cggcgtcgaa cggccaccgt
     9901 ccgtgcccgg cggtcactct ccggacatct tcgtgtgtgc gctgaatgtg ggggtgccgc
     9961 ccccatgtgc gtaccgcgcc ggactgaaag cattaccgcc gtgacgcccc caccatcggc
    10021 gacgtccctg ccgccgaggt ggtgggagca cggccggacc ccgcgcgaac ggacagcgga
    10081 caagcccctc tgggccgact tcgccgaaca cgctgtcacc acgcttctgc cggagcgccc
    10141 cccagtcggt gactggcgtg tgcggttcgc cggggtcttc aggtctctcg tcgacgcagc
    10201 ctcgcgtgac gcggtcccgg acgatctccc cggcgccgac gtcgacgcgc ttcgtcgggg
    10261 cttcgccgcg caactcgacc agcacctgct caacctctcg gtccgtacgc tggtcctcga
    10321 actccaccgc gcccgcaagg ccggagccct ccagggcgag acgcccgaag agcgcttctc
    10381 cgatttcgtg cgccggcagt ccactccggc cgggctggtc cggttgttcg gcgagtaccc
    10441 ggtgctggcc cggctcctgg cccaggcctg cctgtacgcc gccgaggccc acgccgaaac
    10501 gctcgcccgg ttctcggccg acgcggcctt gctgccctgc tcggtcatcg acggcgaact
    10561 cggcacgctc gtcgaggtcg cgggcgggtt cggtgactcg cacgcccgcg gacgttcggt
    10621 caagctgctc cgcttctcca gcggcgccaa ggtgatctac aaaccgcgct cgctgatcct
    10681 gcacgagcgg ttcaccgacg tcgtcgaaca gctcaacaaa cggctgcccg ggctcgaact
    10741 gcgcaccgcc gacgcgctga cgcgtgacgg atacggctgg ctccggttcg tcgaacatca
    10801 gccgtgcgcc gacctcggcg acgtcgaccg cttctaccgc aggcagggca tcctcctggc
    10861 actcctgcac gcgctggacg ccaccgacgt ccactacgag aacatcatcg cctgcggcga
    10921 ccagccggtg ctgatcgaca tcgagaccct gtttcagccg tcgccgcccg tcccgccgga
    10981 gggtgacccc gcggcggcga tgctcgcgcg ttcggtgcag cgcacactgc tgcttcccca
    11041 gctcttcgcc ggcgagcacg gtgccgtcga catctccggc ctcgccggcc gcggtggcaa
    11101 gctgcccacc gaccgggtcg attgggccga cgcgggaacc gaccggatgc ggttggcccg
    11161 ggtgcccggc gaactcgccg gaagcaacaa cctgccccgc ctcgacggcc gcgacgtcgc
    11221 ccccgccgaa cacagcgcgg cgctgctggc cggattccgg ctcggctacg acgcgatctc
    11281 caccggacgg gacgaactcg ccgagcttct ccggcgctgc gccgaggatc ccatccgggt
    11341 gctcatccgg ccgacgaact tctactcccg cctgctggac gagaccaccc atcccgacct
    11401 gcttcgcgac gccgccgacc gcgaccacgc gttcgacctg ctcgaagaag actcggtgcg
    11461 ggaggagaaa ctgctccggc tcgtgccgca cgagcgggac gatctgtggg cgggagacgt
    11521 accgatgttc acgtcgaacc ccggttcgac gtcgctgctg gattcgcgcg gcgacagcgt
    11581 cgaaggggtc gtcgaacagc cgtcgctgga caccgtgctg gcgaaggtcg ccgacatgga
    11641 tccgctcgac cagcgtgatc aggagtggct gatctcggcc accctcgcca tcagcacggc
    11701 ggccgacggc caccacggcg gcggcgagac cgcggaaacg gcggtgccga atcaggcgcc
    11761 ggacgcggag cggttgctgg tcaccgcgtg cgggatcgcc gaccagatcg tcgccaacgc
    11821 cttctccgac gagcatcgct ccaactggct cgggatcgaa ctcgtcgacg accgctactg
    11881 gaccgttctc ccgatgggtg cgggcctcgg cgagggctac tgcggtgtcg cgttgttcct
    11941 cgcacagctc gccgagctga ccgggatcgc gcggtaccgc gatctggccg cgtacgcgat
    12001 cagcccgctt cccggcctct tcgccaccct ccgagccgat cgcgagctgg ccgccaccgc
    12061 cggctgcggc gggcttctcg gactcggcgg tgtcgcgtac acgatcgccc ggctcagcac
    12121 cctggtcggg cttcccgcgg gtgacctcat cgagcaggcc gtcgagctga tgcccgaggc
    12181 cacctccgaa acgccatccg ggttcacgac cgggctcgcg ggtggtgtcg cctcgatgcg
    12241 ttcggtgtat gtccaaacag gactggagac ggcgctggcg cgagccgacc gctacgccgc
    12301 acaactgctc gaacgcgaac gtccgtcgga gaaggccttc gcccgcggtt cggccgggat
    12361 cgactgggtc ctccgggcac acgaccgtcc cggcgaagaa ccacccggaa aggcggacga
    12421 tcgggcggaa agcaccggcg gctggtgcga cggactcgcg ggcgacgccc tcggaatggc
    12481 cgcgcacctg cccgatcccg agcacgccag ggacctggac cggacgatca gacggctgac
    12541 cgacggggca ccgctcaagg atctcagcct gtgccacggc gagtccggag tgctggacgt
    12601 gttgtgcgtg ctggcggaga acgggcacac tggcgccgcg gccgcggtac gccgccggac
    12661 cggtcatctg ctcgccgcca tcgaccagcg cggtgcccgc tgcgggacac ccggcgcggt
    12721 cccctcgcca gggctgctga gtggcctggc ggggatcggc tacggcctgc tgcggctggg
    12781 attcggcgac cgggtccctt ccgcgctcct gctccgcccc gaccggccgc atcccgcggc
    12841 caccgttttt ccgccggtaa accgagtatg aggagaagaa ccacatgtac gaaagagatc
    12901 tgcccgccac cgaagacgtc ctcggcgccg tgaacctgcc gcgcgccctc gaggtcggct
    12961 cgcgcaacca cgcgctggcg ggcagcaagc cgcggctgag cgccaacccg ctcgccaccc
    13021 tgtccacgga caccggttcg ccgtccgtcg tcagcgtctt caccggcggc tggatttaaa
    13081 gacaggctca cggaggcggg ctcgcgccgc ccgccttcgt gatcaacttt tggccgtgac
    13141 agcggaatcc gctcgctata gtcacggcgg tgggtatccg ttcgtcgcgg gtgatcggcc
    13201 gcgacgccga actggccgag ctctccggag ctctcgatcg cgccatcgcg ggccgcggcg
    13261 gcgcgatctt tctcgtgggc gaaggcggca tcggcaaatc ccggctcgcc gtcgaagccg
    13321 cctcgcgagc ggtcgccgcc gacatcccgg tgctgcaggg cagggccagt tcgatcggcc
    13381 cgctcgtccc gttccgtccg ctcacccagg cattgctgtc gcatttccgc ggcgggggcc
    13441 cgccggaggc gaccgaactc gacccgttca ttcccgtact cgctcagctc atccccgact
    13501 ggagtcgagg ggaccggcca cgagagtccg gctccctgct ggtgctcgcc gaagcggtat
    13561 tccggctgct ggccgtcacc agccgcgacc gcggcgcgct cctggtcctc gacgatctcc
    13621 aggacgccga cgccgagaca ctgttcatcc tcgaatacct cgtcgacaac ctgccggcgg
    13681 cgcagaccct gttcgtcggc acgctccgca acgagccctc cgacgcgctg cgcctggcga
    13741 cctccggagc acagcggatg agttgcacaa tcgctgaact cggcaggctc ggcctcgccg
    13801 acacccacgc gctcgccgcc gcctgcctcg agaccgaacc tgggcagttg ccatcggccg
    13861 cgacggaact gttgtggcgc aacagcgccg gccttccgtt catcgtcgaa gaactgctcc
    13921 acggcatggt gaacgacggt ctgctggtcg aaggccgcga cggctggcgc gtcatcggcg
    13981 aactccgcgc ccgcgtcccc gccgcgctgg tcaccagtat cggcgctcgg atggagcaac
    14041 tcggcgagca ggccggcgag ctgctttcgg tcgcggcgat catcggccgc cgcttcccgc
    14101 tgacggtggt gcagaaggtc accgggacca acgaccggac gctgcacaac cacctcggcg
    14161 ccgcggtctc cgcgaacctg gtgaccaccg acgagatgac gcccggctgg tacgccttcc
    14221 gccatccgct gaccgcggaa gcgttgctgg cgcgccagtc accggcgcgg aaggcggaac
    14281 tcgcccggca aaccgccgac gcggtcgagg agctgtaccc gggactgcca ggcgacctgt
    14341 gcgcgctcgt cgcgtcgctc cggctgaccg ccctggatga gcgggccgcg ggccggctgt
    14401 tcgcggagac cggccgtcgc gctctcgacg cgggtgccgc ggactccgcg gtcacgatgc
    14461 tcaccaaggc cctcgacctg ctcgccgggg ccgacgcggg tgatcgggcc gaggtgctgg
    14521 agacgctggt gcacgcgctc gggcagaccg gccagttcga ccgggccgtc gagctttccg
    14581 cggcgttcgg tgagatcggc acgctcgaac gggctgcgaa actgcgcacc cagctggcct
    14641 gggcggccta catcgcgggg cggcacgacg aatgcctcgg ccagatcgaa cgcgcccgtg
    14701 ctcccctcgg ctcggcgatc acccccgctc agcaggcggc actcgacgcc gtcgaagcga
    14761 acctctggct cgacgtcccc ggcaagaccg gcacggccga gcggctcgcg cgtcaggcgt
    14821 ggaaggtcgc cgaggcgacc gagcagccgt tcgtcgtctg ccaggcgttg caagtgctcg
    14881 ggatgctcgc cctgtcgcgg gatctcagcg aatccgagca ctacatgcaa ctcgcgcggc
    14941 ggaccgccga ggacaaccat ctgcaccatc tccgcaccca ggcgctggtc cggctcggcg
    15001 ggcatcgcgt gctgatgaac ggcgacgagc agaccttgct gctcgctcgc gccgacgccc
    15061 agcggaccgg gtcgatcacg ctgcactgcg cggtcgattc cgtgcgcacc atgcacgcga
    15121 tcctgcgctg cgatttcggc accgcgcaca cgttgctcgc ggagaacctc gccgtgctgg
    15181 gcaggctccg gctgaccgcg ttgctgcagt acgcgcatat gaccagggcg atgtcggccg
    15241 ggcaccgggc ggaccgtccc gcgatggagc aggcactcga cgacttccgc gagagcggcg
    15301 gcgagaacgc gcaggagatg gtgctcagca tcgggctggc gcgtgtcttc tgctcgctgc
    15361 tcgaggagga cttcgaccgg gcccgccgcg aactcggcca ggtcatcgag ctggaggacc
    15421 ggcggccgag ccggttccat ctcgccggcc agcacgggct ccggacgctc gtcgacaccc
    15481 tcggcggcgc gccctgcccg gaggacggct ccgcggtgag cgggatgcgg tggaaccggc
    15541 agttcgtcga attcgcgcgc gccgtcgagc acggcaggcg cggtgacgcg gccgaagccg
    15601 aacgagcggt ggcctccgcg ctggagacgt cggcgcccta tcccctggcc cgccacctcg
    15661 ggctccggct gatcgccgag ccggccgcgg ccgacggctg gggcgatccg gcgggctggc
    15721 tcaaggaggc cgaagaatac ttccacggca gggacatcca ggcggtggcg gccgcctgcc
    15781 ggaccctgct ccgcaagctc ggcgcgcccg tccggcaacg gcgctccggg gtcgaccggg
    15841 tgcctggcgg cctgcgcgcg gccggagtca ccgtgcgtga atacgaggtg ctcgtgctgc
    15901 tcgccgagcg gatggggaac aaggacatcg gcgcccgtct gcacatctcg ccccggacgg
    15961 tcgagaagca tgtcgcgagc ctgctcgcca agaccgggct cgccgaccgt gcggccctcg
    16021 ccgaacacgc cgccggaccg cgacctggca tgctgtgagc catgagcgac ctcaccgtgt
    16081 acggcgccgg ctggtgcccc gacgtcaaac gcagccgggc cctactggac tcgaagggcg
    16141 tcgagtacga ctacatcgac gtcgaagcgg actccggcgc ggaggagacg gtgcgcgcgc
    16201 tgcagaacgg tgagcggcgg atcccgacca tcgtctggcc ggacggcacc cacctggtcg
    16261 agccgagcga cgacgagctc accgcgcacc tgaaccggtg accctcccgg acgtcccggt
    16321 cggcacgagg gtcgtcgtgc ggtatcggat cgaaggcggg ttcaccgacg ccctcggcta
    16381 cctgcgctcc cgtgacgaca cggaatgcac ggtggagacc aaacgcggac tcgcgacgat
    16441 ccggctggcg gacatcgtcc tggcgaagac ggtcccgccg cctcctactc cacgcacccc
    16501 tcgtgagcgg taaggacatc agaaccaccg cgtcctctgt acctcctggt cggaagtccg
    16561 tgaaggcctc cttgagggac ccagagtccc tcaaggaggc cttcacgcac tggggcacac
    16621 aggcacggtg ggagcggagg cgtgactcgc gtgattggaa gccgcactcg gggagttccg
    16681 ccgctgatca cgcgagttcc ggcttcgatc acgtgagtgc ggcgccgagg gctagctctt
    16741 gcgcgatttg gtggccttct tcttcgcgtc cttggccttg cccttgaccg tcccgacggc
    16801 gtcctgcagc ggcgcgtagg tgccgaacaa cgcgggatcg ggcttcggag cggtgcccgg
    16861 accgccgagc ggctccgggt ccatcaggta ctcgatcccg tcttcgccga agctccagcc
    16921 gcccttcgcg ccgtccggcc cgtcggacag atgccacacg gtgttgttgt ggtcctggtt
    16981 ctcctcgtcg aacaacgccg tcggcgcgat gtcgctttcc aggccgtcgg ccttgagttc
    17041 ctcgatcgcg gcgagccact gcttctggtg caccgtgtcg cgggcgaggt tgaactgcag
    17101 catggccttc acgccagggt cgtcggtcat gttgtacagc cgggccgtct gcaaccggcc
    17161 ctgcgcctcg gccgcggcgt tcgcccggaa atcggccagc agattgcccg acgcgacgac
    17221 gtagcggccg ttccaggggt agccctggct gtcgctcggg gtggccccgc caccggagat
    17281 gatcgcctgc tgggggtcca tcccgccgag gatcgccgcg gtggccggat ccttcgccgc
    17341 ctcggccacc gtggtggcag gcgccccttc cagcagccgg gcgaccatcg tcgcgagcat
    17401 ctcgacgtgc ccgatctcct cggtcgccgt atccatgatc aaatccttgt acttgccctc
    17461 gatccggcaa ttccagcctt ggaagaggta ctgcatggtc acggtcattt caccgtaggc
    17521 gccgccgatg agttcctgca gctttcgggc gtacaaggcg tccggctttt ccggcttggc
    17581 ctcgaactgg agcgatttgg tgtgacggaa cactgattac ctccgaatac tgggtaaaaa
    17641 cggatcagcg agagtcggcg atcggcgcct tcgaaccgga aagcggaatg agcccgagcg
    17701 cgatcatccc gacggccagc ccgaggtgca gccagttgtc ggcgctgttg accggcacga
    17761 aattcgccgc cgacccgtgg tcgatcagca gtccgtacag ccagagcacg agatagacca
    17821 ccccgccgcc gacgaggaac gccttcgcgc cgcttgccgt ccgggccagc aggatgcccg
    17881 cgacaccgaa cgccaggtgg acgatgttgt gcaggatcga aacctggaac acgcccagca
    17941 gcaaagcgcc ggactcgtgc ccggccccac tcagctgctc gtaattcgtc gtgacgccgg
    18001 gaatgaagcc gagaatgccg acgagcagga agaccgcgcc cacgccgagg gcgatgagct
    18061 ggcgcggagc ccgccgaacg gtggccggcg atgcagtcat gatttcctcc gatccaggtg
    18121 gaatgagctt ctggagcgtc gagtacccgt gccggagccg gtcacaccgg ggaatcggtg
    18181 ttttcgaatt cgtgggaatt cccgtgtaat ccgatgccgc cggggtagcc accgcccagt
    18241 actcacctgg caaggaggcg gaaatcgtgg ccgagcacga ggcaccgcag gcagggccgg
    18301 tcggcaggct tttccgggcc ggcttccact cgctctccgc acttcgcggc gcgcgagcgt
    18361 tccacccgaa cggcctactg ctcaaaggcg agctgcacgc tttgaggcgc gacgatctag
    18421 cgttgccgcc ggaaccggtg accgtcaccg tgcgaatgtc caaaggggcc ggtctcccgg
    18481 gtcgtattcc cgacgcgctg gggctcgcga tccgcgtccc caccgccgac ggcgatccgt
    18541 gggatctcac cctgaccact tcggccgtcc gggtggtgcc gcggccggcg cgatcctgga
    18601 ccaccggccg cttcagctcg ctgctgccct atcgcgtgaa cggcgaactg gtctggctgt
    18661 cggcccgcgc ggaaacgccg cggcgcgccg aagcctcact cgacgccttg agccgactgg
    18721 tgcaggaagg accggtgacc tacctcgtcg aaaccgtccg cgcgaacggg catcggaaac
    18781 cctgcgcgac gctgaccctc cacgaggtgg accaagacgc ctcgcgcccc gccttcgatc
    18841 cgatgctgaa cgctcccccc ggctgggaac tgcggccccg ctggctcacc gggttgcgcg
    18901 agcgcgccta cgagggcagc cgcgaaggcc gctgactcat cccgcgatcg gcttgtccag
    18961 caccgccttc acgtggctga aattctcgat cgagtagcgc ccgtgatagc ggcccatccc
    19021 gctctccccc accccgccga acggcagttc cggcgccgcg agatggatga tcgccgcgcc
    19081 gaacaccagc ccgcccgacg aggtttccgt ctcgatcctg cgcttggttt cctccgattc
    19141 ggtgaaggcg tacagcgcca gcggcttgtc gcgttcgttg acgaacgcca gcgccgcatt
    19201 gacgtcgggc acgtcgatga tcggcaggat cgggccgaag atctcgtccc gcatgaccgg
    19261 ggcgtccggc gagacatccg tgagcacggt cggcgcgatg tacttctcgt cgcggtcggt
    19321 ctggccgccg acgaccgcgg ttccgttgtc cagcaaggcg gcgagccggt cgtggtgccg
    19381 ggtcgagatg atccggccgt aggcttcgct ggtggccggg tcgtcgccga acatcgctcg
    19441 gacggcctcg gccaggtgtt ccgccagctt tgggccggtg tcgccgatcg cgaggacgta
    19501 gtcgggtgcg acgcaggtct ggcccgcgtt ggcgaacttg ccgtaggcca gccgctgggc
    19561 ggtcacggcg aggtccgccc ccggctcgac gatcgccggg ctcttcccgc ccagctccag
    19621 cgtgaccggc gtgagatgct tcgccgccgc ggccatgacg atccggccga ccgtcccgtt
    19681 gccggtgtag aagatggtgt cgaacttctg ctccagcaac gccgtcgtct cggggatcgc
    19741 gccttcgacg acacggacgc cctcgacgta gttcggcaga tgctccgcga tcgcggccga
    19801 ggtgttcggc gacagctcac tcggcttgac gaccgcgcag ttgcccgccg ccagcgcgcc
    19861 gaccagcggc gcgagcacca gttgcagcgg gtagttccac ggcccgatga tcagcgcgac
    19921 ccctagcggc tcgcgaacga cgcggccgtc ggccggtcgc agcggatacg gcaggccggc
    19981 gggctccggg ctcagccagg agtcgagatt ctccagcgtg tggtcgatct cgttccgtac
    20041 gagcgcgatc tccgcgcgct tcgcctcggc ggtgttcttg cgcagatcgg cgtagagcgc
    20101 cttgaggaag acgtcggcct gctcggacag aagggtccgc aggcccgtga gctgcgttcg
    20161 ccgccactcc accggtttcg tgacaccgga gcggaagagg gtgcgcagtt cttcgacgac
    20221 ggcgggggca tcgctgctga tcatggttct gagcctaacc gtgggcggtc actgccgcgc
    20281 ggtatagggc gttatacaag aagcctaagg cgtgactcgc gtgatcaggg acgtgactcg
    20341 cgtgactgga ggccgcactc gggacgttcc acctccttca ctaccttccc caagtacatg
    20401 aaggccccct tccttgcgtc tagggcaagg aagggggcct tcatgtactt cacggtgctc
    20461 aacccggcgg tcgggagtta cgggtagctc accaggttgc tcggccgcgt gtccggcggc
    20521 gtcaccgccc cggcgtcgtt gatcacgtgg gtgatggtcc ccttgtagtt caacgagacc
    20581 gtcaccagat tgtggaaccg gacgccggag cggttcggca cctcgaacgc gtgatacaga
    20641 ttcaccgacg ggttgtcgtt gaagaagcag tagctgccca ggccccacgc ctcgtgcgta
    20701 gtcacgttgt cccccacctt gtaggcggcg tacccgttga gcccgttggg actcttccag
    20761 cccgcctggt ccgggacgtc gtacgggatc tcgttctgga agaagatcgt cctgccgttc
    20821 tggccgttcc agatcacctg gtacttctgg tagtgctcga cgaacaggcc tgtcgccagc
    20881 acgttgtcac cgttgacgac cacaccggtg tcgccggtgt tgatcgtcca gccgtaggtg
    20941 cccgcgttgc cgtggtcggc ccgccaggcc cagatgtggt cgatgatcgt gtcacggctg
    21001 ttgacgatca ggctgttcgt cgccttcccc gcgatctggc cgccgatccg gaagaacacg
    21061 tcctgcaagg tcgtcgggtt cgccgcgtgg ttcgtcgtcg agcccgcctg tccgaccgtg
    21121 agcagcgact gcgagttggt cgtgccggcg tcgaacagca gccccttgag ccggacgccg
    21181 tcgacgtccg cgaccttcat ggcgtcgacg ccgttgtccg gcaccagcgt cgggtagccg
    21241 acgccgagga cgacggtgtt cgccttcgtc acgttgagcg tctggttcag gtgatagacg
    21301 cccggcgtga agaacaggtt gcagccctgg gaaagcgcgg tgttgatcga cgacgccgtg
    21361 tcccccgcct tcacgacgta gaactggctc atcggcagcg aggagccctg ggtgccgccg
    21421 ttggcccagc tcggcccaga ggcgttggtg cgcaaggaag gcaggaacac gcggtacttg
    21481 ccggagccgt cgaggtagag atacgggacg tcgcgggaca ccggcgtggt gccgagcgtc
    21541 gtctccggcg ggttcgggaa ggtgttcgcg ggagcgccgc tcgtcccgga gaagaccatg
    21601 ttccagacgc cgccgtccca gctgccgtag ctgctgtccc gggtgtacca ctgctgctgc
    21661 gagatcgacg cggcctgtcc ggagaccttg gtgtctgcgg tgtagccacc gctcgcgaac
    21721 ccgtagctgg ccgggtagag ctggagcccg ccacggatgt ccatccggcg gaacggcgcg
    21781 gcctgcgcga cggcccagcg ggtcgagccg ctgctcggga cgacggcgag gttctccgcc
    21841 gagcgccaga agttctgcag cgccacaccc ttgtccgact cgttgaacgc gtcgacggtc
    21901 acgtcaccgt tgatcaccac gtcgcccggg ttctgcccga gccccgcgac cgaggtgtag
    21961 tagccgacgt tgtcgtggat gccgttgtac acaccgggct tgaacaggtg cgcgtaccgg
    22021 cgctcggtga actgcgcggt cagggtgtcc ttctgcgcgt tgaagtccgc gtcgagccgg
    22081 gactggatcg acgccgcgga catccccggg tcgaagatcc gcacgttcgg gccgaagtcc
    22141 gggacctcgg cctgcaccgg gcaggtcgcc tgtgtcgatc cgatcgtgta gctcgccgac
    22201 gccaccgggg aattcgccga gccggatttg agcgcgatcg cggagatcgt cgaggacgcg
    22261 gagaccgtga tcggcccggt gtacaaagtg gacgacgccg tcggcgtgga accgtccact
    22321 gtgtaccgga tcgtcgcgcc ggaggtcgcg ctcgacagcg tcaccgaacg cgcgctcgga
    22381 taactgccgc ccggcggatc gaaggtcggt gacgcgacgg tcgtgccgct gccgccgtgg
    22441 gtgtacgtga agtgcggggt gtcgtactgc ggcccgctct tctcgtatgt gaaccaatag
    22501 tcgagcaccg tgcccgccga cagcgagccg acggtgtgcc gccacgtgcc cccgttgtcg
    22561 gtcatgcgga cgttctgctg ccccactccc ggaacgccgg tgtagtggat gtcgacgtag
    22621 cgcgcggggc tcgccggagt gaaggagaac tgcgcctggg tcgcgttcaa ggacgcggcg
    22681 ctctggctgt agtcggcggc cgcggcggtg gcaccaccga gccctgccgc gatcaggagt
    22741 gcggaaaggc cgagggcgag cgcgccccgg aaccctttcc gccgttcggg ctgcacaaag
    22801 atccggttca cgtcgtgaca cctccggcgt tggaaatcca cgggcgaagc gattcgttgc
    22861 gcgccacaac a
//
