LOCUS       NZ_LIVW01000004        21311 bp    DNA     linear   CON 28-MAR-2024
DEFINITION  Streptomyces sp. CB02115 scaffold4, whole genome shotgun sequence.
ACCESSION   NZ_LIVW01000004
VERSION     NZ_LIVW01000004.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CB02115
  ORGANISM  Streptomyces sp. CB02115
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 759400)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 759400)
  AUTHORS   Yan,X., Ge,H., Hindra,F., Yang,D., Huang,T., Crnovcic,I. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-AUG-2015) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC Genomics Workbench v. 7.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905645.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:50:42
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,651
            CDSs (total)                      :: 7,572
            Genes (coding)                    :: 7,475
            CDSs (with protein)               :: 7,475
            Genes (RNA)                       :: 79
            rRNAs                             :: 3, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1 (5S, 16S)
            partial rRNAs                     :: 2 (23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 97
            CDSs (without protein)            :: 97
            Pseudo Genes (ambiguous residues) :: 0 of 97
            Pseudo Genes (frameshifted)       :: 34 of 97
            Pseudo Genes (incomplete)         :: 79 of 97
            Pseudo Genes (internal stop)      :: 9 of 97
            Pseudo Genes (multiple problems)  :: 23 of 97
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:09:48
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 649304
            Orig. end                         :: 670615
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LIVW01000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21311
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="5"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21311
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21311
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11311](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11311
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(957..1976)
                     /locus_tag="AMK28_RS24500"
                     /old_locus_tag="AMK28_24185"
     CDS             complement(957..1976)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003965313.1"
                     /locus_tag="AMK28_RS24500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_24185"
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="WP_073743322.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 7.5e-18, bitscore:
                     60.7, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 3.1e-25,
                     bitscore: 83.9, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRIGLIGTGRIGTFHAEVLSRHPAVDALLLADADPERAAAATART
                     GATAVPVDGLFSGEGAAGGPPDAVVICSATSAHAGLIARAARAGLPVFCEKPIALDLPG
                     TLAALAEVEAAGSVLQLGFMRRFDAGYGEARAAVREGRLGRLHTVRAVTSDPAPPPAAY
                     LPLSGGLYRDCLVHDFDILRWVTGREVSEVYATGSDAGPVMFREAGDVDTAAALLTLDD
                     GTLATATATRCNGAGYDVRMELAGELDQIAVGLDDRTPLTSAEPGGSGAPAKPWPGFLE
                     RFAPAYEAELDAFLRVARGESANPCDGREALHALRIAEACEVSRRERRPVAMTEIPGG"
     misc_feature    2017..2031
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.82"
                     /tool="antismash"
     misc_feature    complement(2018..2031)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.32"
                     /tool="antismash"
     gene            2108..2866
                     /locus_tag="AMK28_RS24505"
                     /old_locus_tag="AMK28_24190"
     CDS             2108..2866
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018961415.1"
                     /locus_tag="AMK28_RS24505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_24190"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_073743323.1"
                     /transl_table=11
                     /translation="MTAHGTDRPLPLSVDRTSPVPLYFQLAQQLEAAVEQGRLAPGALL
                     GNEVDLAARLGLSRPTVRQAIQSLVDKGLMVRRRGVGTQVVHSKVRRPLELSSLYDDLE
                     AAGQRPATGVLRNTTEPATAEVAAALGVAEGSEVHLVERLRSAHGEPMALLRNHLPLGL
                     LPLITEELEATGLYRLMRAGGITLHSARQTVGACAADDRQARALSEPVGAPLLTMERTT
                     YDDTGRVVEFGSHVYRAERYAFEFQLLVRA"
     gene            3155..4135
                     /locus_tag="AMK28_RS24510"
                     /old_locus_tag="AMK28_24195"
     CDS             3155..4135
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1205: ABC
                     transporter, carbohydrate uptake"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153146.1"
                     /locus_tag="AMK28_RS24510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_24195"
                     /product="sugar ABC transporter substrate-binding protein"
                     /protein_id="WP_069755146.1"
                     /transl_table=11
                     /translation="MGAVLAVVLGASLAGCSSTGGKRAEERAAAAAEGRAAVNTPRWTF
                     AMVTHSGDGDTFWDIVQKGAEQAAVKDNINFLYSHNDEANQQAQLVQTAIDKKVDGLIV
                     SLAKPDAMKAVVAKAVKAGIPVVTVNSGSAESKEFGALTHIGQDESIAGEAVGDELNGR
                     DRKKALCVLHEQGNVGHEQRCAGAKKTFDGTMQNLYVDGTNMPDVTASIEAKLQSDKSI
                     DAVVTLGAPFADAAVQAKQTAGSKAEIDTFDLNAKVATGLQTDKLGFAVDQQPYLQGYE
                     AVDLLWLYRYNRNVLGGGLPVLTGPQIITKDDADALADYTKRGTR"
     gene            4132..5178
                     /locus_tag="AMK28_RS24515"
                     /old_locus_tag="AMK28_24200"
     CDS             4132..5178
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1113:
                     inner-membrane translocator"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018961417.1"
                     /locus_tag="AMK28_RS24515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_24200"
                     /product="ABC transporter permease"
                     /protein_id="WP_050357357.1"
                     /transl_table=11
                     /translation="MSGSTAAPDQLDERLVRTSPLRKLLGRPELGSVVGAAAVFLFFAI
                     VADSFLQASSLGTVLYAASVLGIMAAPVALLMIGGEFDLSAGVMVTSSALISSMFSYQM
                     TANVWVGVFVSLLVTLAIGAFNGFMLTRTKLPSFIITLGTFLMLTGLNLGFTKLISGTV
                     STKAIGDMEGFDSARALFASTLTLGGVEFKVTILWWAALVGVATWILLRTRFGNWIFAV
                     GGEADAARAVGVPVIRTKIGLYLGVAFAAWVSGQHLLFSYDVVQSGEGVGNELTYIIAA
                     VIGGCLITGGYGSAIGSAVGAFIFGMTSKGIVYAEWNPDWFKFFLGAMLLLATLLNAWV
                     RKRAEATA"
     gene            5175..6032
                     /locus_tag="AMK28_RS24520"
                     /old_locus_tag="AMK28_24205"
     CDS             5175..6032
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012378422.1"
                     /locus_tag="AMK28_RS24520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_24205"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_050357358.1"
                     /transl_table=11
                     /translation="MTATPEDPAGATAGPLVELDDVSKFYGNIKALEHVSLEVHAGEIT
                     CVLGDNGAGKSTLIKIIAGLHRHDAGRFLIDGEETALANPRDALDRGIATVYQDLAVVP
                     LMPVWRNFFLGSEPTVGFGPFKRLDVRKMRETTRTELLRMGIDLRDVDQPIGTLSGGER
                     QCVAIARAVYFGAKVLVLDEPTAALGVKQSGVVLKYVAAARDAGLGVVLITHNPHHAHL
                     VGDRFILLKRGAMSGSHTKDDVTLDELTRQMAGGSELEELSHELERTPTPTLPGAHGTK
                     DETP"
     gene            6166..7332
                     /locus_tag="AMK28_RS24525"
                     /old_locus_tag="AMK28_24210"
     CDS             6166..7332
                     /EC_number="2.7.1.2"
                     /GO_function="GO:0004340 - glucokinase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1108: ROK family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003965308.1"
                     /locus_tag="AMK28_RS24525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_24210"
                     /product="ROK family glucokinase"
                     /protein_id="WP_050357359.1"
                     /transl_table=11
                     /translation="MSTYRDFAHRGSARATVLKTVGTKERRSHLTAPRVPTVGIDIGGT
                     KVMAGVVDADGNILEQLRTETPDKSKSPKVVEDTIVELVLDLSDRHDVHAVGIGAAGWV
                     DADRSKVLFAPHLAWRDEPLRDAIASRLVVPVMVDNDANTAAWAEWRFGAGRGEDHLVM
                     ITLGTGIGGAILEDGQVKRGKYGVAGEFGHMQVVPSGHRCPCGNRGCWEQYSSGNALVR
                     EARELAAADSPVAHYLLDRVKGNVSDITGPLITELAREGDAMCIELLQDIGQWLGIGIA
                     NLAAALDPSCFVIGGGVSAADDLLINPARDAFKRHLTGRGYRPEARIAKAQLGPEAGMV
                     GAADLARLVARRFRRANRRRVERYERYAQIYDQAASTIRNTRSTRTAD"
     gene            7402..7998
                     /locus_tag="AMK28_RS24530"
                     /old_locus_tag="AMK28_24215"
     CDS             7402..7998
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015612389.1"
                     /locus_tag="AMK28_RS24530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_24215"
                     /product="hypothetical protein"
                     /protein_id="WP_047179560.1"
                     /transl_table=11
                     /translation="MIAAEHPVVPHQSESPGDGEGKPPEDRRHVFKRRFITATIIVLLI
                     GIPAGYLLISAGQSRRSGQDKEAEAAAQGLREGWPSKMQRRIFEIPIPGNGQGVQYYET
                     NNWKASRMYAKFRTTSAGLDRFLTGVGTGRAALEPDTIDISPRDIKITGWSFGPGEEWA
                     STTHKNKKPRPTQNITVNMTDPASPVVYVVSAATP"
     gene            8499..9911
                     /locus_tag="AMK28_RS24535"
                     /old_locus_tag="AMK28_24220"
     CDS             8499..9911
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003965306.1"
                     /locus_tag="AMK28_RS24535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_24220"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_073743324.1"
                     /transl_table=11
                     /translation="MTVDSSSEARLEVPRQSSLGTAAARNLASTTKSAPQMQEITSRWL
                     LRMLPWVETKGGAYRVNRRLTFTVGDGRVEFVQDGAAVRVIPQELGELALLRDFDDAEV
                     LTAIADRCVQRDFRAGETLVERGTAADQLHLIAHGRIGQTSAGGYGDEVTLDVLADGDR
                     FGEHALLDDDARWTQTATAETSGTLLTLSRADFAAVVANSPDLRAHLAEFTARSGQRQN
                     HRGEAEIAMSAGHVGEHDLPGAFADYELKPREYELSVAQTILRVHTRVADLYNGPMNQT
                     EEQLRLTIEALRERQEHELINNREFGLLHNADFKQRVQTHSGPPTPDDLDELLCRRRGT
                     KFFLAHPRTIAAMGREFNARGLYPDHTDLGGQQVPAWRGVPILPCGKIPITPERTSSIL
                     AMRTGEENQGVIGLRQTGLPDEYEPGLSVRFMGIDEKAIISYLVSTYYSAAILVPDAVG
                     VLENVQIANWPR"
     gene            10001..11311
                     /locus_tag="AMK28_RS24540"
                     /old_locus_tag="AMK28_24225"
     CDS             10001..11311
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012378420.1"
                     /locus_tag="AMK28_RS24540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_24225"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     terpene cyclase"
                     /protein_id="WP_073743325.1"
                     /sec_met_domain="T1TS (E-value: 1.4e-68, bitscore: 227.5,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVPELPPPQSSLPEAVTRFGANVLGAVAARAHDTDAVGGPTGGR
                     PLPGPPAGLSFGPSATAVPPTSVPVTDAPGQGVGLERLLRGPHGLGTAGLRLTPREERP
                     VTPVPREGRPIPGLYHHPVPEPDEARVEEVSRRIKAWALDEVSLYPEEWEEQFDGFSVG
                     RYMVGCHPDAPTVDHLMLATRLMVAENAVDDCYCEDHGGSPIGLGERLLLAHTALDPLY
                     TVRAYQPEWADSLHADAPRRAYRSAMDYFVRAAGPSQADRLRHDMARLHLGYLAEASWA
                     QQDQVPEVWEYLAMRQFNNFRPCPTITDTVGGYELPADLHARADMQKVIALASNATTIV
                     NDLYSYTKELDAPGRHLNLPVVIAEREGLSDQDAYLKSVEVHNELMHDFETEAAALAAA
                     CPVPAVQRFLRGVAAWVDGNHHWHQSNTYRYSLPDFW"
     gene            11345..12223
                     /locus_tag="AMK28_RS24545"
                     /old_locus_tag="AMK28_24230"
     CDS             11345..12223
                     /EC_number="2.1.1.255"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0042214 - terpene metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018512513.1"
                     /locus_tag="AMK28_RS24545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_24230"
                     /product="geranyl diphosphate 2-C-methyltransferase"
                     /protein_id="WP_050357363.1"
                     /transl_table=11
                     /translation="MTSAELTTAPTLRIPGPATPYQGDIARYWDGEARPVNLRLGDVDG
                     LYHHHYGIGEVDTASLGNPEDSESEKKLITELHRLESAQAEFLLGHLGDIGRDDTLVDA
                     GCGRGGSMVMAHQRFGCSVEGVTLSAKQADFANGRAAELGIGDHVRARVCNMLSTPFAT
                     GSAAASWNNESSMYVDLDDLFAEHSRVLKVGGRYVTITGCWNPRYGQPSKWVSQINAHF
                     ECNIHSRREYLRAMADNRLVPQAVIDLTPDTLPYWELRATSSLVTGIEDAFINSYRDGS
                     FQYLLIAADRV"
     gene            12416..13405
                     /locus_tag="AMK28_RS24550"
                     /old_locus_tag="AMK28_24235"
     CDS             12416..13405
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00881"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012378419.1"
                     /locus_tag="AMK28_RS24550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_24235"
                     /product="nitroreductase family protein"
                     /protein_id="WP_073743326.1"
                     /sec_met_domain="PF00881 (E-value: 8.8e-11, bitscore: 37.4,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRDRVTEAVPALVAAAVAAPSMHNAQPWRFVHHADTGVLSLYGDP
                     DRALPVGDPEHRGMHLGCGGALFNLRVAAAQQGWNAVTEAFPDRRDPWRLVDVTLEEPG
                     TVPFDRVLADLFPAVEARHTNRSPFSDEQIPPEIFDELCAAALLEGARLAVPSDWHADD
                     LVDLVHDAELHEAASDLMRAEIIAWTRTGRAGEGPEAEGVPSYAFGPRQHDVKVPVRDF
                     GLPRDTQRRATATFEERPQLAVLGTETDDPADWLRAGQAMERILLVATRDGLATSMMSQ
                     PLEWPELRSMARDPASRMGFVHMVFRLGYGPPAVATPRRPVADVLTVV"
     gene            13814..14980
                     /locus_tag="AMK28_RS24555"
                     /old_locus_tag="AMK28_24240"
     CDS             13814..14980
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008736598.1"
                     /locus_tag="AMK28_RS24555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_24240"
                     /product="DNA gyrase subunit B"
                     /protein_id="WP_241837564.1"
                     /transl_table=11
                     /translation="MSGKSMGYDAVRIEALEGREAVRKRPGMWVGSTGERGLHELVLQA
                     VSWSVNRVLADREGGSVEVTLTHDGGVRVADDGPEVPLTADGKIGDSGLEELLTAMPAA
                     ERGGRRNVHLSPVGCRGLFVPNVLSSRLTAEVRHRGTRRVQEYARGVAVARPAAAGPTT
                     GSGTVIAFWPDAELFETTRCSFAVLAERFRQVAFLNRGLGISLTDERPAGGARAVSFRF
                     PDGVRDFVAALDAERAGFFHPDVFGFEHEDPRMAGVMEVALLWNGSHRERVRGFANSWA
                     TRQGGTHLDGFRDGVVAAVTAYARGQGLLTGDDVLCADRIGDGLTAVVSVKLDCPEYLG
                     ATRELLGNTEVRGCVGEAVRERLGSWFEERPKRAAEIVDRILRNTRQA"
     gene            15461..16570
                     /locus_tag="AMK28_RS39715"
     CDS             15461..16570
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK28_RS39715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_198957953.1"
                     /transl_table=11
                     /translation="MTGTEWAAVRPLMPVPAWPEGRSGQPEGCQHRSMPDAIRHLVAGH
                     GLVAEFHDRLRGRGREREGRHAEHSAGIIDARSGPSRARQVGEHISWPLTCNLGLAPGV
                     VSVMSSSQILRGRGATATLQKSAVVVDRDQVRTTIPFEVIQEARVGGRRARTVEIVLTD
                     GRTHELRANNATSAQAFTAAVNAGLPAEPDPRGSGLVRTKRLRAPEAPPLFTDWRIPSA
                     VLCGAVAYCGYLIYLGVAHSSVLIIGAVLGLFPLILGSVGTFLSVKHLCDKVVLRRRGV
                     TVEALSLHKLHGRSEYRFIDGEGSKRIFKSALNTGRLEVTYDPRNSKRMAASISLSLLL
                     AVPVTVLKLAVALILVAVGVVAAFSPVIP"
     misc_feature    complement(16864..16879)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.55"
                     /tool="antismash"
     misc_feature    17072..17083
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.59"
                     /tool="antismash"
     gene            17346..17501
                     /locus_tag="AMK28_RS24575"
                     /old_locus_tag="AMK28_24255"
     CDS             17346..17501
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK28_RS24575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AMK28_24255"
                     /product="hypothetical protein"
                     /protein_id="WP_338015667.1"
                     /transl_table=11
                     /translation="MTDLSRVIDDPAVWAPIDRIVGTLYKVLPELFAPDCNRRLEAAPH
                     RLWPED"
     gene            17861..19248
                     /locus_tag="AMK28_RS24580"
                     /old_locus_tag="AMK28_24260"
                     /pseudo=""
     CDS             17861..19248
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015493161.1"
                     /locus_tag="AMK28_RS24580"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_24260"
                     /product="NF041680 family putative transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSLLQHGAPRDAFTELSCFRTELYACLTGRRDALFELSLEPEHRR
                     GHGALYGGLNSGDLDVARLRRTLAGLPFPPRRRVGWSWRSTRATGCGRTRIPARIGCSA
                     TRTVVAGARPR"
     gene            complement(19258..20571)
                     /locus_tag="AMK28_RS24585"
                     /old_locus_tag="AMK28_24265"
     CDS             complement(19258..20571)
                     /GO_function="GO:0003979 - UDP-glucose 6-dehydrogenase
                     activity [Evidence IEA]"
                     /GO_function="GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /GO_function="GO:0051287 - NAD binding [Evidence IEA]"
                     /GO_process="GO:0000271 - polysaccharide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1152: nucleotide sugar dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018386101.1"
                     /locus_tag="AMK28_RS24585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_24265"
                     /product="nucleotide sugar dehydrogenase"
                     /protein_id="WP_241837565.1"
                     /transl_table=11
                     /translation="METNALNASDSGGICMDVVIMGQGYVGLPLAVHAAEAGHHVVAYD
                     TDVQRVKQLTVGETYIGDMSGARVKRLMESGLFHPTANPDEIHPFDVGVIAVPTPLVDG
                     VPDLGHVESATVTLARWLRPGATVVLESTTYPGTTRNVVGALLEEHSGLTVGADFHLGF
                     SPERIDPGNSTWRLSNTPKLVAGIDDRSLGALSRFYGSFVDTVVPVPGCEEAEFAKILE
                     NTFRHVNVALVNELAAIGRDLGIDVWSAIDAAATKPFGFMRFTPGPGVGGHCLPIDPQY
                     LSWHARRTLHRSSRFVELADEVNAGRPAMVVERVIRGLNSRKLAVNGARVLVLGLSYKK
                     NVGDTRESPSARVISGLAELGADLRLADPHVPEDSEVAGSANGATRVGCVQTELAAADI
                     TVLLTDHDSFDYAEVAEHARYVLDCRHRMPKLDHIEYL"
ORIGIN
        1 gaccacaccc ggatgcgcaa gctggtcacc cgtgagttca ccccgcgtcg tatggagcaa
       61 ctggccccgc gtatccagga gatgaccgac gagctgctgg actcgatgct cgcggccccg
      121 gcccgtgcgg cggacctggt cgaggcgctc tccttcccgc tgcccatgtc ggtgatctgc
      181 gagctgctcg gcgtcccgtc cctggaccgc gaggccttcc gcacctggtc cggccaggcg
      241 gtctcctccg tcgacccgtc cctgcgcgcc tcctccacgc aggcgatgac cgcgtacatc
      301 gccgggctgc tcgccgacaa gcgcgagaat ccgggcgagg acctgctgag tgcgctgatc
      361 cacacctccg acgagcacgg cgaccggctg tccggcgacg aactgatcgg catggcctgg
      421 ctgttgctgg tcgccggaca cgagaccacc gtcaacctca tcaccaacgg cgtgcacaac
      481 ctcctcgccc accccgatca actggacgcc ctgcgagcgg acttcacact gatcgacaac
      541 gcggtcgagg agatcctgcg cttcgagggg ccggtggaga cccccaccta ccgcttcacg
      601 accgatccgg tcgaggtcgc cggggtgatg atccccggcg gcggcgagct ggtcctcgtc
      661 gcgatgtcgg acgccaaccg ggaccccgtc cgctaccccg acgggtcccg cttcgacatc
      721 acccgcgacg cccggggtca catcgccttc gggcacggca tccactactg cctgggcgcg
      781 ccgctggccc gcatcgaggc caggatcgcc atccggtcgc tgctggaacg ctgtccggac
      841 ctgcggctgg ccgccgaccc ggcgacgctc gcctggcgca ccgggatcct gatgcggggg
      901 ccgctgagcc tcccggtcgc ctggtagcgg ccggcccggc aggtccggag cccggttcag
      961 ccgccgggga tctcggtcat cgccaccggc cggcgttccc ggcgggagac ctcgcacgcc
     1021 tcggcgatcc gcagggcgtg cagggcctcc cgcccgtcgc acggattggc cgactcgccc
     1081 cgggccacgc gcaggaacgc gtccagttcc gcctcgtacg ccggggcgaa ccgttccagg
     1141 aaccccggcc agggcttcgc cggggcgccg gaacccccgg gctcggccga ggtcagcggc
     1201 gtacggtcgt ccaggccgac ggcgatctgg tccagttcgc cggccagctc catccgtacg
     1261 tcgtacccgg cgccgttgca ccgggtcgcg gtggcggtag cgagcgtccc gtcgtcgagg
     1321 gtgagcagag cggcggccgt gtccacgtcc ccggcctccc ggaacatcac gggtccggcg
     1381 tccgagccgg tggcgtacac ctcgctcacc tcgcggcccg tcacccagcg caggatgtcg
     1441 aagtcgtgga ccaggcagtc gcggtacagc ccgccggaga gcgggaggta ggcggcgggc
     1501 ggcggggccg gatcggaggt gaccgcccgc acggtgtgca gccggccgag ccttccctcc
     1561 cgcacggcgg ccctggcctc gccgtacccg gcgtcgaagc gccgcatgaa gccgagctgg
     1621 agaacgctgc ccgccgcctc gacctccgcg agcgcggcga gcgtgccggg caggtccagg
     1681 gcgatcggct tctcgcagaa gacgggcagc ccggcacggg cggcccgtgc gatgagcccg
     1741 gcatgggccg aggtcgccga acagatcacc acggcgtcgg gcgggccccc ggccgcaccc
     1801 tctccgctga acagaccgtc caccgggacg gccgtcgccc ccgtccgcgc cgtggcagcg
     1861 gccgcccgct ccgggtccgc gtccgccagc agcagggcgt ccacggcggg gtgacggctc
     1921 agcacctccg catggaatgt gccgatccgt cccgttccga tcagtccgat gcgcatgggc
     1981 cccaaggtgg cgttcgcccg gtcgtcatgt caagcgtttg tcctgacaaa tggcggccgc
     2041 gtcaatcggc tgctccccgc cccggtacgc catggctttg tccggacaag cgaactacgc
     2101 tcgccccgtg accgcacatg gaaccgaccg gccgctgccg ctgagtgtgg accgcaccag
     2161 cccggtgccg ctctacttcc agctggcgca gcagctggag gccgccgtgg aacagggccg
     2221 gctggccccc ggcgccctgc tcgggaacga ggtcgacctc gccgcccgcc tcggcctgtc
     2281 ccggccgacc gtccgccagg ccatccagtc gctcgtcgac aagggcctga tggtccgccg
     2341 ccggggagtc ggcacccagg tcgtccacag caaggtccgc cggccgctgg agctcagctc
     2401 gctctacgac gacctggagg cggccggcca gcgccccgcc accggcgtcc tgcgcaacac
     2461 cacggaaccg gccaccgccg aggtcgccgc cgcgctcggc gtcgccgagg gcagtgaggt
     2521 ccacctcgtc gaacggctgc gcagcgccca cggcgaaccg atggccctcc tgcgcaacca
     2581 cctgcccctc gggctgctgc ccctgatcac cgaggaactg gaggccaccg gcctctaccg
     2641 gctgatgcgg gccggtggca tcacgctgca cagcgcccgc cagaccgtgg gcgcgtgcgc
     2701 cgcggacgac cggcaggcac gggcgctgtc ggagcccgtg ggcgccccgc tgctcacgat
     2761 ggagcgcacc acgtacgacg acaccggccg ggtggtcgag ttcggctcgc acgtctaccg
     2821 ggcggagcgg tacgccttcg agttccagct cctggtacgc gcctgagccc gtccggcccc
     2881 catccagccc acgccggacg ggcggggggt gcgggcgcca accgccgcgc aagcatgttc
     2941 ggaccaacgg ttgacgtgaa catgtggcgc gactagaact cgctgcaccg aaggacgcgc
     3001 ccccaccggc cctgccgggc gggagcgggc ggggctcggg gatacttggg cagccgggcc
     3061 gggaccgtac actccccggc cccgtcaagc agcacagcga gcagcagtag aagggcacgg
     3121 cgtcgtggca agggttcgga caggggtacg cgcgatgggc gccgtgctgg cagtggtgct
     3181 gggcgcctcc ctcgcgggat gcagcagcac cggcggcaag cgcgccgagg agcgcgcggc
     3241 cgccgcggcc gagggacggg ccgcggtgaa cacaccgcgc tggaccttcg ccatggtcac
     3301 ccactcgggc gacggcgaca ccttctggga catcgtccag aagggcgccg agcaggcggc
     3361 cgtgaaggac aacatcaact tcctctactc gcacaacgac gaggccaacc agcaggccca
     3421 gctcgtccag accgcgatcg acaagaaggt cgacgggctg atcgtctcgc tggccaagcc
     3481 ggacgcgatg aaggccgtgg tcgccaaggc cgtcaaggcg ggcatcccgg tcgtcaccgt
     3541 gaactccggc tccgcggagt ccaaggagtt cggcgcgctc acccacatcg gccaggacga
     3601 gtcgatcgcc ggtgaggccg tcggcgacga gctgaacggc cgggaccgca agaaggccct
     3661 ctgcgtcctg cacgagcagg gcaacgtggg ccacgagcag cgctgcgccg gggcgaagaa
     3721 gaccttcgac ggcacgatgc agaacctgta cgtcgacggc accaacatgc ccgacgtcac
     3781 cgcgtccatc gaggccaagc tccagtccga caagagcatc gacgcggtcg tcaccctcgg
     3841 ggcccccttc gccgacgcgg ccgtccaggc caagcagacc gccggcagca aggccgagat
     3901 cgacaccttc gacctgaacg ccaaggtcgc caccggcctc cagaccgaca agctcggctt
     3961 cgccgtcgac cagcagccct acctccaggg ctacgaggcc gtcgacctgc tctggctcta
     4021 ccgctacaac cgcaacgtcc tcggcggcgg cctccccgtc ctgaccggcc cgcagatcat
     4081 caccaaggac gacgcggacg ccctggccga ctacaccaag cggggcacgc gatgagcggc
     4141 tccaccgccg cccccgacca gctggacgag cgtctggtgc gcacctcgcc gctgcgcaag
     4201 ctgctcggcc gccccgagct cggctcggtc gtcggcgcgg cggccgtctt cctgttcttc
     4261 gcgatcgtcg ccgacagctt cctccaggcc tccagcctcg gcaccgtgct gtacgcggcc
     4321 tccgtcctcg gcatcatggc cgcaccggtc gccctgctga tgatcggcgg cgagttcgac
     4381 ctgtccgccg gcgtcatggt gaccagctcc gcgctgatct cctcgatgtt cagctaccag
     4441 atgacggcca acgtctgggt cggcgtcttc gtgtcgctgc tggtcacgct cgccatcggc
     4501 gcgttcaacg gcttcatgct gacccgcacc aaactgccga gcttcatcat cacgctcggc
     4561 acgttcctga tgctgaccgg cctgaacctc ggcttcacca agctcatcag cggcaccgtc
     4621 tccaccaagg ccatcggcga catggagggc ttcgactcgg cccgcgcgct gttcgcctcg
     4681 acgctgaccc tcggcggcgt cgagttcaag gtgacgatcc tgtggtgggc ggcgctcgtc
     4741 ggcgtggcca cctggatcct cctccgtacc cgcttcggca actggatctt cgccgtcggg
     4801 ggcgaggccg acgcggcccg cgcggtcggc gtcccggtca tccgcaccaa gatcgggctc
     4861 tacctgggcg tcgccttcgc cgcctgggtc tccggccagc acctgctgtt cagctacgac
     4921 gtcgtccagt ccggcgaggg cgtcggaaac gagctgacgt acatcatcgc cgccgtcatc
     4981 ggcggctgcc tgatcaccgg cggctacggc tccgcgatcg gctcggccgt cggcgccttc
     5041 atcttcggca tgaccagcaa gggcatcgtg tacgccgagt ggaacccgga ctggttcaaa
     5101 ttcttcctgg gagcgatgct gctcctggcc accctgctca acgcgtgggt gcgcaagcgc
     5161 gcggaggcga cggcatgacg gccacccctg aagaccctgc cggagcgacc gccggaccgc
     5221 tggtcgagct cgacgacgtg tccaagttct acgggaacat caaggccctg gaacatgtct
     5281 cgctggaggt ccacgcgggc gagatcacct gcgtcctcgg agacaacggc gccggcaagt
     5341 ccaccctcat caagatcatc gcggggctgc accggcacga cgccggacgc ttcctgatcg
     5401 acggcgagga gaccgcgctc gccaacccgc gcgacgccct ggaccggggc atcgccaccg
     5461 tctaccagga cctcgccgtc gtccccctca tgccggtctg gcggaacttc ttcctcggct
     5521 ccgaacccac cgtcggcttc ggtcccttca agcgcctcga cgtccggaag atgcgcgaga
     5581 cgacccgtac cgaactgctg cgcatgggca tcgacctgcg cgacgtcgac cagcccatcg
     5641 gcaccctgtc cggcggcgag cgccagtgcg tggccatcgc ccgcgccgtc tacttcggcg
     5701 cgaaggtcct ggtcctggac gagccgaccg ccgccctcgg cgtcaagcag tccggcgtgg
     5761 tcctcaagta cgtggcggcc gcccgcgacg ccggcctcgg cgtggtcctc atcacgcaca
     5821 acccgcacca cgcccacctc gtcggcgacc gcttcatcct cctcaagcgc ggcgcgatgt
     5881 ccggcagcca caccaaggac gacgtcacgc tggacgagct gacccggcag atggcgggcg
     5941 gcagcgagct ggaggagctc agccacgagc tggaacgcac cccgaccccc accctcccgg
     6001 gcgcccacgg cacgaaggac gagactccct gagcggcgac cgccccggcg cggccgaccc
     6061 cgcccaccgg ccccccgggg ccgggcagtg gcagaatcga gcccggcggg cgccgtccgc
     6121 caccggccgc gacagcggcc cggcccccca gaccccgcag ggacgatgag cacgtaccgc
     6181 gacttcgcac accgcggctc cgcccgcgcc accgtcctca agaccgtcgg caccaaggaa
     6241 cgccgctcgc atctcaccgc cccccgggtc cccacggtcg ggatcgacat cggcggcacc
     6301 aaggtgatgg cgggcgtcgt ggacgccgac ggcaacatcc tggaacagct ccgcaccgag
     6361 acgcccgaca agtccaagag ccccaaggtc gtcgaggaca ccatcgtcga actggtcctg
     6421 gacctctccg accgccacga cgtccacgcg gtgggcatcg gcgcggcggg ctgggtggac
     6481 gccgaccgct ccaaggtcct gttcgccccg cacctcgcct ggcgcgacga acccctgcgc
     6541 gacgccatcg cctcccgcct cgtcgtcccc gtcatggtcg acaacgacgc caacacggcg
     6601 gcctgggcgg aatggcgctt cggagcgggc cggggcgagg accacctcgt catgatcacc
     6661 ctcggtacgg gcatcggcgg cgcgatcctg gaggacggcc aggtcaagcg cggcaagtac
     6721 ggcgtggccg gtgagttcgg ccacatgcag gtcgtgccgt ccggccaccg ctgcccctgc
     6781 ggcaaccggg gctgctggga gcagtacagc tccggcaacg ccctcgtccg cgaggccagg
     6841 gaactggccg ccgccgactc cccggtcgcc cactacctgc tggaccgggt gaaggggaac
     6901 gtctccgaca tcaccgggcc gctcatcacc gaactggccc gcgagggcga tgcgatgtgc
     6961 atcgaactcc tccaggacat cggccagtgg ctcggcatcg gcatcgccaa tctggccgcc
     7021 gcgctcgacc cctcctgctt cgtgatcgga ggcggtgtca gcgccgccga cgacctcctg
     7081 atcaaccccg cccgggacgc cttcaagcgc cacctcaccg gccgcggcta ccgccccgag
     7141 gccaggatcg ccaaggcgca gctcggcccc gaggcgggta tggtcggcgc cgcggacctg
     7201 gccaggctgg tcgcccgccg attccgccgg gccaaccggc ggcgcgtcga gcggtacgag
     7261 cggtacgccc agatctacga ccaggcggcg agcaccatcc gcaacacgcg ctccacccgt
     7321 accgctgact gaaccgcagc cgccctttcc ggcgtccacc cttcagtacg ccgtccgcag
     7381 caccttaggg accacctgat catgatcgca gccgagcacc ccgtggtgcc gcaccagtcg
     7441 gagtctccgg gcgacggcga gggcaagccg cccgaggacc ggcggcatgt gttcaaacgg
     7501 cgtttcatca ccgcgacgat catcgtgctg ctgatcggca tcccggccgg ctatctgctg
     7561 atctcggccg gtcagagccg ccgctcgggc caggacaagg aggccgaggc ggccgcccag
     7621 gggctccgtg agggctggcc ctccaagatg cagcgccgga tcttcgagat cccgatcccc
     7681 ggcaacgggc agggcgtcca gtactacgag accaacaact ggaaggccag ccggatgtac
     7741 gcgaagttcc ggacgacctc cgccggtctc gaccgcttcc tgaccggggt gggcaccgga
     7801 cgcgcggcgc tggagcccga cacgatcgac atcagccccc gggacatcaa gatcaccggc
     7861 tggtccttcg gcccgggcga ggaatgggcc agcaccacgc acaagaacaa gaagccgcgc
     7921 ccgacccaga acatcacggt caacatgacc gacccggcca gcccggtcgt gtacgtcgtc
     7981 tcggcggcga ccccctgacc gggagcctct gagcgcgtcg gcccggcacc gggtgtgccg
     8041 cgccgccacc gagcgcatcg acccggtggc cccgcgtgcg tgtcggcccc ggcggtgatc
     8101 caccgccggg gccgccgtgt gtccgcgtgc tgtcgtgttc gcgggcgctc taccgtgtcc
     8161 cgcgcgtcat ccccgccgtc ggcctgcccc gaccggccgg attgcatcgc gcctccgcgg
     8221 cttcgagccg tgtgggcccg gaaggctgcc gaacaccccg ctccgacgac ggctgaaatc
     8281 cgtcggcacc ggggcaaaca tccagcgggc gcgatcatcg tatcgagcta atgtcagcgg
     8341 atttccttgg tcgggaggcc ggaggggacc ttagtgttcc cctggatctg atctggaggg
     8401 attccccttc atatcgcccc tttgcctcac tttttcaccc tttcgtaggt tcgcgtccgc
     8461 tatgcgcgtt cccgctccga ccaaggagag cctgcccgat gactgttgac tcgagctcgg
     8521 aagcgcggct ggaagtgccc cgccagtcca gcctggggac ggccgccgcc cgcaacctcg
     8581 ccagcacgac gaagtccgcc ccgcagatgc aggagatcac ctcccgttgg ctgctgcgga
     8641 tgcttccctg ggtcgagacc aagggcggcg cctaccgggt caaccggcgg ctcaccttca
     8701 ccgtgggcga cgggcgggtg gagttcgtcc aggacggggc cgcggtccgg gtcatccccc
     8761 aggagctggg cgaactggcc ctgctgcggg acttcgacga cgccgaggtg ctgacggcca
     8821 tcgccgaccg gtgcgtccag cgtgatttcc gggcggggga gacgctggtc gagaggggca
     8881 cggcggcgga ccagctccat ctgatcgcgc acggccggat cggccagacc tccgccggcg
     8941 gctacggcga cgaggtcacc ctggacgtcc tggcggacgg cgaccgcttc ggcgagcacg
     9001 ccctgctgga cgacgacgcc cggtggacgc agaccgccac cgccgagacc tcgggcacgc
     9061 tgctcactct gtcccgcgcc gacttcgcgg ccgtcgtggc gaactcgccg gacctccggg
     9121 cccacctcgc cgagttcacc gcgcgctccg ggcagcggca gaaccaccgc ggtgaggcgg
     9181 agatcgcgat gtcggccggc cacgtcggcg agcacgatct gcccggagcg ttcgccgact
     9241 acgaactgaa gccgcgcgag tacgaactct cggtcgccca gaccatcctg cgggtccaca
     9301 ccagggtcgc cgacctctac aacggcccga tgaaccagac cgaggaacag ctcaggctca
     9361 ccatcgaggc gctgcgtgag cgccaggagc acgagctgat caacaaccgg gagttcggcc
     9421 tgctccacaa cgccgacttc aagcagcgcg tccagacgca ttccggcccg ccgaccccgg
     9481 acgacctgga cgagctgctc tgccgccgtc ggggcaccaa gttcttcctc gcgcaccccc
     9541 ggacgatcgc ggcgatgggg cgcgagttca acgcgcgcgg cctctacccg gaccacaccg
     9601 acctcggtgg ccagcaggtt cccgcctggc gcggtgtgcc gatcctgccc tgcggcaaga
     9661 tccccatcac cccggagagg accagctcga tcctcgccat gcgtaccggc gaggagaacc
     9721 agggcgtcat cggtctgcgg cagaccggcc tgccggacga gtacgaaccg ggcctctcgg
     9781 tccgcttcat gggcatcgac gagaaggcga tcatctccta cctcgtcagc acctactact
     9841 ccgccgccat cctcgtgccc gacgcggtcg gcgtcctgga gaacgtgcag atcgccaact
     9901 ggcccaggta gtggtcgcgg cccacgtggc ccggcccggc gaagcgggcc gcctgcccgg
     9961 acgccgcaga acacccgccc cccaccaagg agagccacgc atgcccgtgc ccgagctgcc
    10021 acctccgcag tcgagcctgc cggaggccgt cacccgcttc ggggcgaacg tgctcggcgc
    10081 ggtcgcggct cgcgcccatg acaccgacgc cgtcggcgga ccgaccggcg gacgccccct
    10141 gccgggcccg cccgccgggc tgtccttcgg cccgtcggcc accgccgtac cgccgacctc
    10201 cgtaccggtg accgatgcgc ccggccaggg cgtcgggctg gagcggctgc tgcgcgggcc
    10261 ccacggcctg ggcacggccg ggctgcggct gacgccccgc gaggagcgtc ccgtaacgcc
    10321 ggtcccccgg gaaggccggc cgatcccggg cctgtaccac cacccggtcc ccgagcccga
    10381 cgaggcgcgc gtcgaagagg tcagccggag gatcaaggcc tgggcgctgg acgaggtctc
    10441 tctgtacccc gaggagtggg aggagcagtt cgacggcttc tccgtgggcc gctacatggt
    10501 cggatgccat ccggacgcgc ccaccgtcga ccacctgatg ctcgccaccc gtctgatggt
    10561 cgccgagaac gcggtggacg actgctactg cgaggaccac ggcgggtcac ccatcggcct
    10621 gggcgagcgg cttctgctcg cgcacaccgc gctcgacccc ctgtacaccg tgcgcgcgta
    10681 ccagccggag tgggcggact cgctccacgc ggacgccccc cggcgcgcct accgctccgc
    10741 catggactac ttcgtccgcg cggccgggcc ctcccaggcg gaccggctcc gccacgacat
    10801 ggcgcgactg cacctcggat atctcgccga ggcgtcctgg gcccagcagg accaggtccc
    10861 cgaggtctgg gagtacctgg cgatgcgcca gttcaacaac ttccggccct gccccaccat
    10921 caccgacacc gtcggcggtt acgagctccc ggcggacctg cacgcccggg ccgacatgca
    10981 gaaggtcatc gccctggcct ccaacgccac gacgatcgtg aacgacctct actcgtacac
    11041 caaggagctc gacgccccgg gccggcacct gaacctgccc gtcgtgatcg ccgaacgcga
    11101 ggggctgtcc gaccaggacg cctacctcaa gtcggtcgag gtccacaacg agctgatgca
    11161 cgacttcgag accgaggccg cggcactggc cgccgcctgc cccgtcccgg ccgtgcagcg
    11221 cttcctgcgg ggcgtcgccg cctgggtcga cggcaatcac cactggcacc aatcgaacac
    11281 ctaccgctac agcctgcccg acttctggta ggccccgaca tccggcaaga gatgggaacc
    11341 atctgtgacc agcgctgaac tcaccaccgc ccccaccctg cgtatccccg gccccgcgac
    11401 gccctaccag ggagacatcg cccgctactg ggacggggag gcccggcccg tgaacctacg
    11461 cctcggcgat gtcgacggcc tctaccacca ccactacggc atcggtgagg tcgacaccgc
    11521 ttcgctcggc aaccccgagg acagcgagag cgagaagaag ctgatcaccg agctccaccg
    11581 gctggagtcg gcccaggccg agttccttct ggggcacctc ggtgacatcg ggcgcgacga
    11641 cacgctggtg gacgcgggct gcggccgggg cggctcgatg gtgatggcgc accagcgctt
    11701 cggctgttcc gtggaaggcg tgacgctgtc ggccaagcag gccgacttcg ccaacgggcg
    11761 cgcagcggaa ctgggaatcg gcgaccacgt ccgcgcccgc gtctgcaaca tgctctccac
    11821 gcccttcgcg accggttccg ccgcggcgtc gtggaacaac gagtcgagca tgtacgtgga
    11881 cctggacgac ctcttcgccg agcactcccg cgtcctgaag gtcggcggtc gctacgtgac
    11941 catcaccggc tgctggaacc cgcgctacgg ccagccctcg aagtgggtct cgcagatcaa
    12001 cgcgcacttc gagtgcaaca tccactcgcg cagggagtac ctgcgcgcca tggccgacaa
    12061 ccgcctcgtg ccgcaggccg tcatcgacct cacccccgac accctgccct actgggagct
    12121 gcgcgccacg tcctcgctgg tcacggggat cgaggacgcg ttcatcaact cctaccggga
    12181 cgggtccttc cagtacctcc tcatcgcggc cgaccgcgtc tgacggcgcc cggtccattg
    12241 gccggccggc accgaggaca cccccggtgc cgaccggcca tctcggcgtt cggcatgagc
    12301 cggcgcggcc gcggggttag tttggaagga ggcggtccga tcgggtggaa gcggccggac
    12361 gcatcgcggt tcaccggggc ggcgcgacgg ccttgtggaa cgagaaggaa ctgtgatgag
    12421 agaccgagtc accgaagcgg tcccggcact ggtggcggcg gccgtcgccg cgccgtccat
    12481 gcacaacgcc cagccgtgga gattcgtcca ccacgcggac accggcgtcc tctcgctgta
    12541 cggcgatccg gaccgtgctc tgccggtcgg cgaccccgag caccggggca tgcatctcgg
    12601 atgcgggggc gcgctgttca atctgcgggt ggccgccgct cagcagggct ggaacgcggt
    12661 caccgaggcg ttcccggacc gccgggatcc ctggcgcctg gtcgatgtca cgctggagga
    12721 gcccggcacc gtgcccttcg accgggtgct ggcggacctc tttcccgctg tggaggcccg
    12781 gcacaccaac cgctccccgt tctccgacga gcagatcccg ccggagatat tcgacgagct
    12841 gtgcgcggcc gcgctcctgg aaggggcccg gctagccgtt ccgagcgact ggcacgccga
    12901 tgacctcgtc gacctcgtgc acgacgcgga gctccacgag gccgccagcg atctcatgcg
    12961 ggcggagatc atcgcctgga cgcgcacggg gagggcgggg gaggggccgg aggccgaggg
    13021 agtgccctcc tacgcgttcg gtccgcgcca gcacgacgtg aaggtgcccg tgcgggactt
    13081 cgggctgcct cgggacacgc agcgccgtgc cacggccaca ttcgaggagc gccctcagct
    13141 ggcggtgctc ggcacggaga cggatgaccc cgcagactgg ctccgggcag ggcaggccat
    13201 ggagcggatc ctgctcgtgg cgacgcggga cggcctggcg acctcgatga tgtcgcagcc
    13261 gctggaatgg ccggagctga ggtcgatggc ccgcgatccc gcatccagga tgggcttcgt
    13321 ccacatggtc ttccgcctcg gctacggccc cccggcagtg gccaccccgc gcagaccggt
    13381 cgccgatgtg ctcaccgtcg tgtgacgcac cggcgcgtgt ccggtcgcac caccacaatc
    13441 ccgcgggccg ggtgcctggc gggcagggtg tcgattctct tggcacttca acgagttgga
    13501 cacgcatgcg gagcgacgaa gctgctcgca ggcggacggt caacaagatc atccgttccg
    13561 cctggagctt cgcgcgccgt gtattcgtcg tcgatggaat gggaagcctc gggggtgccc
    13621 ggagtgaggg cgtacgcggc tccgccgggg ccgtggccgt gttccggcat ggtctgtggc
    13681 acctggggcc aaccgcttcc cggcacgctc tcacccaccc gcccacagct tcgccggagc
    13741 gcctctggcc tggtgttttc atggattctg cttaggctgc ggagatctgc cgagcatcgt
    13801 gggaggggtc ttcgtgagcg ggaagagcat ggggtacgac gctgtcagga tcgaggcgct
    13861 ggaggggcgg gaagccgttc ggaaacggcc cggtatgtgg gttggctcga cgggcgaacg
    13921 cgggctgcac gagttggtgc tccaggccgt gagctggtcc gtgaaccgtg tcctggccga
    13981 ccgcgaaggc ggctccgtcg aagtcaccct gacccacgac ggcggtgtgc gggtcgccga
    14041 cgacggaccg gaggtgcccc ttacggccga cgggaaaatc ggcgacagcg gtctcgaaga
    14101 gctgctgacc gctatgcccg ccgccgaacg cggcggtcgg cgcaacgtgc acttgagccc
    14161 cgtcggctgc agggggctct tcgtgcccaa cgtcctgtcg agcagactga cggccgaggt
    14221 gcggcaccgg ggaacgcgtc gggtccagga gtacgcgcgc ggtgtcgcgg tcgcccggcc
    14281 cgccgccgcg gggccgacga caggaagcgg gacggtcatc gccttctggc ccgacgcgga
    14341 gctcttcgaa acgacgcggt gctcgttcgc cgtgctggcg gagcgcttcc ggcaggtggc
    14401 cttcctcaac cggggcctgg ggatctcgtt gaccgacgag cgcccggcgg gcggggcccg
    14461 ggcggtgagc ttccggtttc cggacggcgt gcgggacttc gtggccgccc tcgacgcgga
    14521 aagggcgggt ttcttccatc cggacgtctt cggcttcgag cacgaggatc cgcggatggc
    14581 gggggtgatg gaggtggccc tgctgtggaa cggctcccac cgggagcgcg tacgaggctt
    14641 cgccaacagt tgggccactc gccagggagg cacgcacctg gacggcttcc gggacggagt
    14701 ggtggcggcg gtcaccgcgt acgcgcgtgg acaagggctg ctgacggggg acgacgttct
    14761 ctgcgccgac cggatcggcg acggcctcac ggcagtcgtg tcggtgaaac tcgactgccc
    14821 cgaatacctc ggcgccacgc gcgagttgct gggcaacacc gaggtgcgcg gctgcgtcgg
    14881 ggaggctgtc cgtgaacgcc tcggcagctg gttcgaggag cggccgaagc gcgccgcgga
    14941 gatcgtcgac cggatcctcc ggaatacccg ccaggcctga actgggtagt ggagcgcgca
    15001 ttcgcccacc tgcacgggtt ccgccgcctg cggatccgcc gggagatccg cgacgacatc
    15061 cacgaagcct tcctcagcct cggatgcgca ctcatctgct ggcggcgact gcgcgctcct
    15121 gtgaccgatg ccgtgggcta gctatctgcc cccggccggt tgaggacttc cctgggggtg
    15181 aagctccagc cgaccggacg cggcccgctc cagttgatgc cgaacacgaa ggggaagctt
    15241 cgcatgccgt cggcggagag gtgagtcggg cttccgtcgt catcccggac aagccgtatc
    15301 ccaagcggtc atggaacgtg cgagtcgaac gggttcccgc cggggtgctc ttccggcggt
    15361 aggcgcatga aggcaggtcc ccttggtagc tcgaaggtgc gaaccgaacc gagcagttcc
    15421 aggagggcat cctgatcggg tgtgccggta cccgtcggat atgacgggca cggaatgggc
    15481 ggctgtgcga ccgctgatgc cggtgccggc ctggccggaa ggcaggagtg ggcaacccga
    15541 gggctgccaa caccgctcga tgcccgatgc gatccgccac ctggtggcgg ggcacgggct
    15601 ggtcgcggag ttccacgacc ggctgcgtgg acggggccgt gagcgcgagg gtcggcatgc
    15661 ggagcattcc gccgggatca tcgacgcgcg gtcgggcccg agccgcgcac gccaggtggg
    15721 cgagcacatc tcatggcccc ttacatgcaa ccttgggctc gcgccgggag tcgtttcggt
    15781 catgtcctcc tctcagatcc tccgcggtcg cggggccacc gcgaccctgc agaagtcagc
    15841 cgtcgtcgtc gaccgcgacc aggtgcgcac caccattccg tttgaagtca tccaggaggc
    15901 acgcgtaggc ggacgtcgcg cgcgtacggt cgagatcgtc ctcaccgacg gcaggactca
    15961 cgaactccgg gcgaacaacg ccacctccgc gcaagcgttc acggctgccg tcaacgccgg
    16021 ccttccggcg gaacccgatc cgcgcggaag cggacttgtc cgaaccaaga ggttgcgtgc
    16081 gcccgaggca ccgccactgt tcaccgactg gcgcatacca tctgcggtcc tctgtggagc
    16141 agtcgcgtac tgcggatacc tgatatatct cggcgtcgcg cattcatccg tgctcatcat
    16201 cggtgcggtc ctcggcctct tccccctcat cctcggctcg gtaggcactt tcctgtcggt
    16261 gaagcacctg tgcgacaagg tcgtgctgcg acggagaggc gtgacggtcg aggcgctctc
    16321 attgcacaaa ctgcatggga gatcggagta ccgattcatc gacggagagg gcagtaaacg
    16381 catcttcaag agtgcgctca acacgggaag gctcgaggtg acctacgacc ccaggaactc
    16441 gaagcggatg gctgcgagca tttcgctttc gctactgctg gcagtgccgg taacggtcct
    16501 gaaactggct gtcgccttga tcctggtggc agtgggcgtg gtcgccgcct tcagccccgt
    16561 gattccctga cgccccgtgt gctcgcacct ggcccctggg cggtcctcgc actcacggcc
    16621 aggaccgccg gccggcactg aatgcccccg gcgcctccag gatttcctcc ggcgaacaag
    16681 ggggtgccgc accaccttct cgcccgccgg gacgggcaca ttgacgtccg cacgaccaag
    16741 cgctggtctg tgaagccgga tgtggaggat ctacggtcgg cggccgatag gtggggaggt
    16801 ctggcgagcg ctccggcccc agcttatgag gcgaacgtga gatgtgggag cgtgagtggg
    16861 tgagtgagaa gaacgttgag cccctgaagt actgcgtcga cgggccggaa gacgctccgt
    16921 tcctggtcat aggtccctcg ctgggtacca catggcacag gttgtgaatc atgtcttgtg
    16981 gggtctcggt cggtccaggt gagctgtata aggccagttc aggcccttgc tgtccaggta
    17041 cgtcgactct gttggtgaga tgtgtgtgag agaaaacgct tctagcacga gacacgacga
    17101 gcccccgccg acctctgtcg gcgggggctc gtcagtgcaa ttggccgtgg gttcggccgt
    17161 cgggctgatg ggtatcgggg cgctggcgga ggccctacat agttggtcat ggtcggaggc
    17221 cagtagggtt cgggtggtcg agggtgaggg ccgtgccgta ggggtgggca tgggcgacag
    17281 tcaggtcacg attgagctca cgcctgatga ggcgctgctg ctgtcgcatt ggttggagaa
    17341 gctccgtgac ggacctcagt cgtgtcatcg acgatccggc agtctgggcg ccgatcgatc
    17401 ggatcgtcgg gacgttgtac aaggtgctgc ccgagctgtt cgcgcccgat tgcaaccggc
    17461 ggcttgaggc tgctcctcat cggttgtggc cggaggactg agctcacctc cgctcgcgcg
    17521 gagagcacac gcggtcgggg gtgccggggc tgacatctca cctccgctcg cgcagagagc
    17581 acagcaggtc ccgcgccgcg ttgtgcgtga tcggcggctc acctccgctc gcgcggagag
    17641 cccgaggccc agatccgcgg tgaatcgtgt accaggcagc ctcaagagtc ggtcaagctc
    17701 cacagtggct tcgttgctac taagcttgac gtttatggtc tgccgtcgaa catggcctcg
    17761 aacttgctga tgggtttgcc taagttctgg acgtaagagc ggccttcgcc tgatcctgtg
    17821 ctccgtcaca gaggcaggga tcaacacgaa ggccgtagct atgagtctgc tgcaacacgg
    17881 cgccccgcgg gatgcgttta ccgaactgtc atgcttccgg acggagctct atgcctgtct
    17941 gaccggccgg cgtgatgcgc tgttcgagct gtcgttggag cccgagcacc ggcgcgggca
    18001 tggcgccttg tacggcgggc tgaacagcgg ggatctggat gtggcacggc tgcgcagaac
    18061 gctggcaggg ctgccgtttc ccccacggcg tcgggtcggc tggtcctggc ggtcgacgcg
    18121 agcaactggc tgcggccgga cgcgaatacc agcccggatc ggctgttctg ccacacgtac
    18181 ggttgtggca ggggctcggc ccagatgatc cccgggtggc cctactcctt cgtggccgct
    18241 ctggaacctg gccgcacgtc gtggactgcc ctgctggacg tggtccggtt gtgtccgtgg
    18301 gacgacgcga tcgccgtcgc cgccgcccag gtccgggacg tgtttcagcg gctgtatgtg
    18361 acaggccagt ggcagatcgg tgacccgccc gtcctggtcg tcgtcgatgc cggctatgac
    18421 gtgacccgtc tggctttcct gctcgcggac ctgcccgtgg agctgctggg ccggatgcgt
    18481 tcggaccgcg tcctgtactt cccgcccccg ccccagccgg cgggcagacg tgggcgcaag
    18541 cccaagcgcg gggcggagtt cgcgttcgag atcgcggcca ctcaaccggt cccgtcggcc
    18601 accacggtga ccgacaccac tcactacggg aaagccgtcg ccactgcctg ggaccacctg
    18661 cacccgctac tggtccggcg ctcggcctgg gccgaccacc ccgaaggaga cctgccggtc
    18721 atcgaaggca ccgtcatccg tcttcagatc gaccacctcc gcggagaccg cagccccagg
    18781 tcggtctggc tgtggtggtc ggccactgcc gccactgctg gggatgtgga ccggctgtgg
    18841 caggcattcc tacgcagaat cgaccttgag cacaccttca ggatgttcaa gcagacgttg
    18901 gggtggaccg ctcccaaact tcgcgagcca gccgccgccg accgctggac ctggctcgtc
    18961 atcgcagccc acacccaact ccgccttgcc cggcccctcg cagaagacat ccgcaatccc
    19021 tgggaacggc ccgcccgcca agggcgcctc acacccgcgc gagtccgtcg aggatttcgc
    19081 cgcctccaca ggaaaacgcc tcagctggcc agcgcaccga aacccagcac cgcaggcccc
    19141 ggcaggccaa tcgggatcaa gaacaagcac cgcgcacgcg agcaccccgt cgggaaagag
    19201 gacaaaccca acctcgcggc ggccgtcgca agcagcagag ctgcataaac gtcaagctta
    19261 gagatactcg atgtggtcca gctttggcat gcggtgccga cagtcgagta cgtaccgcgc
    19321 atgttcagcg acttccgcgt agtcgaatga gtcgtgatcg gtcagaagca ccgtgatgtc
    19381 cgcagctgct agctccgtct gaacacaacc aactcgggtc gccccgttgg cgcttccggc
    19441 cacctccgaa tcctccggca cgtgcgggtc ggccagtcga agatcagcgc cgagctcggc
    19501 caagccactg atgacacgtg ccgacggcga ctcgcgagtg tctccgacat tcttcttgta
    19561 gctcagcccg agtaccagca ccctggcccc gttgacggcc agtttccgag agttgagccc
    19621 gcggatgact cgttccacca ccatcgcggg gcgcccggca ttcacctcgt cggcgagctc
    19681 gacgaagcgg gaagagcgat gcagggttcg gcgggcatgc caggacagat attggggatc
    19741 aatgggaaga cagtggcctc ccacaccagg cccaggggtg aaacgcatga aaccgaacgg
    19801 tttggtggct gccgcgtcga tggccgacca gacatcaatc cccaagtctc ggccaatggc
    19861 agccaattca ttcacgagtg cgacgttgac gtgccggaag gtgttctcca ggatcttcgc
    19921 gaactcggcc tcttcgcacc cgggcaccgg cacgacggtg tcgacgaagc ttccatagaa
    19981 acgactcagc gcacccaggg agcgatcatc aattccggcc acgagcttcg gggtgttgct
    20041 cagtctccag gttgaattgc ctggatcaat acgttcggga ctgaagccga gatggaaatc
    20101 agccccgacc gtgagcccgg agtgttcctc aaggagtgca ccgacgacgt tccgcgtggt
    20161 gccgggatag gtggtcgact cgaggaccac cgttgcccct gggcgcagcc atctcgccag
    20221 ggtcacagtg gcgctctcca cgtgaccgag gtccggcacg ccgtcgacga gaggtgtggg
    20281 gaccgcaatg acgccaacat caaacggatg gatctcgtcc ggattcgccg tcggatggaa
    20341 cagtccggat tccatcagac gtttgacgcg tgcacccgac atgtctccta tatacgtctc
    20401 accgacggtc agttgcttga cgcgttgaac gtcggtgtcg taagcgacga catgatgccc
    20461 tgcctcagcc gcatgcacag cgagcggaag ccccacgtat ccctgcccca tgatcacgac
    20521 gtccatgcag atccccccgc tgtcgctagc gttcagcgca ttggtctcca tagtcggccg
    20581 cctgtccggc gagacggaac cccaccctca gaactggcat gccagccgtc cgacagctct
    20641 cagaagtggg tctgaagtac ggttctctgg atccgcggct cagactgccc gacgatcgac
    20701 ctcgccatta ggcgacgacc ggccaggccg gttcggacat gacgtcggtg cagggcccgc
    20761 agccctggca gcacgctgct ggccggcttg gaccgagagg tgttgtcggt gattctctgc
    20821 ataccgtttc tggcatccga ccccacccag ttcgatcctg cctggatcga acgcggctgg
    20881 ggggtggagg caaatctatt tgaccgacac gacatcgctg acgccgactc gtggcgcgaa
    20941 gtgcagagta ccgtccgacg ggttgcacag acgaatcggc cgcaggcgtt caccttccac
    21001 tttccagtga acgactgcga ctacctcgac gacccattga tggaacaacg cctcttcgag
    21061 gcgatcgaca tggtagccga caatgagctg gatggactgg ttctgcattc caaccgcata
    21121 cgcagtgcgg aggaatggcg ccgcctggac atcgccgcgg aacgcgaccg tcttcgtgag
    21181 tacgtgactc ggcttgcgga cagagtagac ggcgcatctt tctggatcgg gctggagaac
    21241 atgccgatca ccgggaacga cgcccaggaa ctggacccct tgctcgtatt cccggatgac
    21301 tttcggggaa t
//
