LOCUS       NZ_LIVW01000003        11368 bp    DNA     linear   CON 28-MAR-2024
DEFINITION  Streptomyces sp. CB02115 scaffold3, whole genome shotgun sequence.
ACCESSION   NZ_LIVW01000003
VERSION     NZ_LIVW01000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CB02115
  ORGANISM  Streptomyces sp. CB02115
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 1032236)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1032236)
  AUTHORS   Yan,X., Ge,H., Hindra,F., Yang,D., Huang,T., Crnovcic,I. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-AUG-2015) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC Genomics Workbench v. 7.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905645.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:50:42
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,651
            CDSs (total)                      :: 7,572
            Genes (coding)                    :: 7,475
            CDSs (with protein)               :: 7,475
            Genes (RNA)                       :: 79
            rRNAs                             :: 3, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1 (5S, 16S)
            partial rRNAs                     :: 2 (23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 97
            CDSs (without protein)            :: 97
            Pseudo Genes (ambiguous residues) :: 0 of 97
            Pseudo Genes (frameshifted)       :: 34 of 97
            Pseudo Genes (incomplete)         :: 79 of 97
            Pseudo Genes (internal stop)      :: 9 of 97
            Pseudo Genes (multiple problems)  :: 23 of 97
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:09:48
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 162283
            Orig. end                         :: 173651
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LIVW01000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11368
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11368
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11368
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6368](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6368)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(1580..3319)
                     /locus_tag="AMK28_RS18105"
                     /old_locus_tag="AMK28_17885"
     CDS             complement(1580..3319)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018955801.1"
                     /locus_tag="AMK28_RS18105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_17885"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_073742323.1"
                     /transl_table=11
                     /translation="MMLHPELLRAANTARRPLGLATALLAAVTATHLAQAVLLALVLAR
                     IARGETAALAPLLTAVIAVVLVRAGLGRAQRLTAVTAGATVRIGLRDTLLERLGALGPT
                     PITGARAGAVRATLVDGVEGVDAYVSRYLPQALITCAVPPLLLVAVALVEPYAALALGP
                     ALLLALLGPRWWDRLLARRGKEHWDSYEALAADYLEALQGMPTLRATGAVGRVRERLER
                     RSAALHRTTVAKLRVSLVDTGLTDLAVQGGTAAAVLVACSSAATGRTAATGTYLLLLLA
                     SECFRPVRDLSREWHAGYLGVSAADGIAGLRTAEAAVPDRGTVAADWASAPEIRFEDVH
                     FTHPGSGRPALDGVSFTAAAGRTTAVVGPSGAGKSTLLSLLLRQRDPDRGRLTVAGTAT
                     AAYTLASLRRGIAVVSQDTYLFHATIAENLRIARPAATDEQLQAAARTAGIDQEIARLP
                     DGYATLVGERGATLSGGQRQRLALARALLADAPVLILDEATSAVDERGQARIVRELSAA
                     GRGRTCVVVAHRLDAVRHADHIVVLDAGRVAATGDHTTLLAGGGVYASLVAAGRTAQEE
                     RAA"
     misc_feature    3730..3745
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.02"
                     /tool="antismash"
     misc_feature    4299..4319
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 17.64"
                     /tool="antismash"
     gene            complement(5001..6368)
                     /locus_tag="AMK28_RS18115"
                     /old_locus_tag="AMK28_17895"
     CDS             complement(5001..6368)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010059075.1"
                     /locus_tag="AMK28_RS18115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_17895"
                     /product="YcaO-like family protein"
                     /protein_id="WP_079199056.1"
                     /sec_met_domain="YcaO (E-value: 1.4e-44, bitscore: 148.9,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSALPIEALVDPVSGIIRDVAPVEHPTGAPPRYTAMTADVADAR
                     RLGAWPADRVSLGTTFGDPRGAWIAAVAEAVERYCGNRLPPPGHPQEPRRATAADLTAE
                     GHRLYGPGALPTYAPWQYVRPGFPYAELNPDTTALWTRATENGRPCWAPVALTHLNWRQ
                     GGLRSLPRTHHLNYAGIATGQGLDDAVERGLLEVVERDALELWWHLDGPTRGIDPASVP
                     GLTDDLAGCGLDVHIVEMPSEFAPCVAALAHDPVRGIYAAGFACRYDPAEAARKAVLEA
                     VHTWVFTQGAVDADGWVYRAVEAGMLARGLYLDHRADRRYLDDCGAEFAAVRDLGAHVQ
                     VWLDDRMAPLARRFTEPALGTVPVTAIDPGSRTALDTALAAGGHRVITADLTTEDVAET
                     SLRVARVLVSGLIPNAPAAFGYFGCPRFADAALARGWRTRPPAAPGDFTLAPPPHM"
     gene            complement(6365..8080)
                     /locus_tag="AMK28_RS18120"
                     /old_locus_tag="AMK28_17900"
     CDS             complement(6365..8080)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012377868.1"
                     /locus_tag="AMK28_RS18120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_17900"
                     /product="CocE/NonD family hydrolase"
                     /protein_id="WP_079199034.1"
                     /transl_table=11
                     /translation="MNTLTVYVPMPDGTALATDVCLPDGTRPLPAVLIRTPYGREAHRA
                     ELRGWAAHGFAALAQDVRGRHGSPGEWHPYRDHEETDGAATVAWVRAQAWSNAEVVAAG
                     ASYAAYCALVTALATPETACDTGPDADPGDFHRGGVLDNLHRDGAPGGLHGDGVPDAVI
                     AAVPALGLTETAREPGGPERLWARAGWWAAHGDRRDSDPDALTRALADDPRLLEHLPVA
                     RLAERLAASLGRELPSWAGLWADRARGRLVALGSTARLPLLAVGGTRDPFAEDTVALWR
                     GWGGPSRLLLGPWGHRLTADPAAPARARVNLGALYVRWARAALAGRLEPTRHGAIALGD
                     SGRWHSTRLRSTPRPAITQAATTQDATVQEGAEWRAGADRPEAGSRWSFDSPTGLRLLH
                     GAEFNADPDRPVRSDDLAVPADGDRADRCLLLSPPLPRPLDLAGAAVARINVTADTPCA
                     DWAVRLTALDPTGRADPLAFGIVRRTGPPGEAADISVPLGTLGRRLPAGTRLRAEIAGH
                     HFPAHARNPHTGEDPVTATRLAPSRRTVDPRGSALHLPVVARRRYVEPAPEICR"
     gene            complement(8077..9057)
                     /locus_tag="AMK28_RS18125"
                     /old_locus_tag="AMK28_17905"
     CDS             complement(8077..9057)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007452727.1"
                     /locus_tag="AMK28_RS18125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_17905"
                     /product="hypothetical protein"
                     /protein_id="WP_073742326.1"
                     /transl_table=11
                     /translation="MTRSRLAPGTGIVTVPGGAPVLRTSGGEFLRIDTGGVTGEDLVRR
                     LAGEGAPEEETPDEGAQTAELGRLVEAFEAAGYALSTPPRAPLAGRTVHVLGDPVLTAP
                     VARCAGAEGAEVHRITPDGVAELARVAPDDGAEGRVAVVWCLDSPVPEGLWDTADRLPG
                     RRIAWLRCHREGAHSWMEPLAAAPGDVTSRHIRLRRLAATPAHRELAAYWAGHRTPDTG
                     PHPTEASAALIAALLTADLIAWAEAEAEAEAEAEAEAEAEAGEVEGAGTGRTTVLPVRR
                     RLRRIDLRDLTLTEHPVLPVPDVAPLPAPAAVRTRAAAGTAEARP"
     gene            complement(9187..9321)
                     /gene="amiA"
                     /locus_tag="AMK28_RS40090"
     CDS             complement(9187..9321)
                     /codon_start=1
                     /gene="amiA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015508296.1"
                     /locus_tag="AMK28_RS40090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="streptamidine family RiPP"
                     /protein_id="WP_007452728.1"
                     /transl_table=11
                     /translation="MENNKVFSPIADQGQLAHLSATHSNALVENPFDDAVEADTAAEK"
     misc_feature    9311..9328
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 13.87"
                     /tool="antismash"
     misc_feature    9395..9408
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 12.45"
                     /tool="antismash"
     misc_feature    complement(9395..9410)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.88"
                     /tool="antismash"
     gene            complement(9396..10169)
                     /locus_tag="AMK28_RS18130"
                     /old_locus_tag="AMK28_17910"
     CDS             complement(9396..10169)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010639452.1"
                     /locus_tag="AMK28_RS18130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_17910"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_241837549.1"
                     /transl_table=11
                     /translation="MVLRGVDLSVRAGELVALIGLNGCGKSTFLKLAAGLLAPSGGRVL
                     LEGDDVTRLPRRTAARRVALLHQSAPTVPGLTVRQLVRQGRYAARGPLGMLREGDDEVT
                     SRALADVGVTAWADRPVDALSGGERQRVRLAMALAQDARVLFLDEPTTYLDLRHQLEVL
                     QTVVRLRAERRLTVVMVLHDLNHAARFADRIVALREGRVAADGPPAEVVTRRLLAEVLG
                     VEGRVGIDSEGGWPVCYPDHPLDPLQLLRNENHIH"
     misc_feature    10163..10177
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 17.77"
                     /tool="antismash"
     misc_feature    10810..10819
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
ORIGIN
        1 tgggccgtcg tctcgtccag gacgagtacg cgcggcccgc tcagcagccc ccgggccagg
       61 gccacccggg cgcgctggcc gccggacagg gtcgcaccgc gctcgccgac ggcggtgtcc
      121 agcccgtcgg gcagggcgtc ggcgatgggg gcgatgccgc agatccgggt caccgcgccc
      181 agttcgtccg ccgtggcgtc gggagtgccc aggcggaggt tctcggcgag ggtgccgtgg
      241 aagagcgggg cctcctgccc caccacggac acggcggcac gcaggtccgc ctcggtgagg
      301 tcccgcaggt ccacggggtg ggccggggcg gcgggcacga gctccacggc gccggcctcg
      361 gggtcccagt accgcgccag gaggtgtgcg caggtcgact tgcccgcccc ggactctccg
      421 acgagggcca cggtctcgcc cggccggacg gtcaggtcga ggccgtccag gaccggctcg
      481 cccccgtagc cgaaccggac tccgcgcagc cgcaggccca gcgggcccgc cggtacgggg
      541 cggggggcgg cggaagcggg ggctccggcg ggggcgtgca gggcggcccg gacccgtgag
      601 gcggcggcgc gcaggctgcc cgcccggccg agtgcggccg ccgattcggc gaccggggcc
      661 agggctccca gcgccagggc catggcggcc ggggcccacg ccccgtccag acgtccggcg
      721 gacgcggcgt gggcggcggc cgccaccacc ccgatgacgg cggcgacgac cagcagatcg
      781 cgggtcgcgc ccgccccggt ctcccaggac tgttcggcgc gctgggcgcg ggcgagtccg
      841 cggcccgcgg accgcagccg ggcccgcctg cggttcagcg cccccgccat caggagttcg
      901 cgcagcccgt cgacgctctc caccgtctcg gacgagacct cggcgagcgc gctccgggtc
      961 cgcgccccgc gttcggcccg cccgcgcgct tcgaacagcg gcgaccagat caggaggagc
     1021 gcggcgggca cgacggcgag cagcagccag gggccgaggg ccgccagcac agccgccgac
     1081 accgcgaaga ccaggccgga ggcgaggagt tgggcgatgg cgtgggcgta gaagaactcc
     1141 agtgcctcga cgtccccgag cgcggtggcc gcgaggtcgc cgctgcgccg gcccgcgatc
     1201 cgggcggggg cgctgcgggc cagcccgtcg aagacccgca cgcgcagttc ggcgaggacc
     1261 cggtaggcga ggtcgtgtga gaggtccatc tcccgccagg tggcgagggc ccggagcagg
     1321 acgagcccga tcaggacggc gacggtcccg gtggtgggcg ggcggtgctc cgtgacggct
     1381 gtgcccaccg tgtacgcggc gagggtcacg agggcgacca gggccgcctg gtcgacgagg
     1441 gcggccaggc aggtgcgcag cacggtggcg cggtgcgcgc cgaggaccgg gaggagcgag
     1501 cgcagggcgc cggtccctga gtcgtcgggg gtggcgggga ccggggaacg ggcggggtcg
     1561 gtcggggccg gggtcggggt catgcggcgc gctcctcctg tgcggtgcgc ccggccgcga
     1621 cgagcgaggc gtacacgccg ccgcccgcga gcagggtggt gtggtcgccc gtcgcggcga
     1681 cgcggcccgc gtcgaggacg acgatgtggt cggcgtggcg tacggcgtcg agccggtggg
     1741 cgacgacgac gcaggtgcgt cctcggccgg ccgccgacag ttcccgcacg atgcgggcct
     1801 ggccgcgttc gtcgaccgcg ctggtggcct cgtccaggat caggaccggg gcgtcggcca
     1861 gcaacgcccg tgcgagggcg agtcgttggc gctgtccgcc ggagagcgtg gcaccgcgtt
     1921 cgccgacgag ggtggcgtaa ccgtccggca gccgggcgat ctcctggtcg atccctgcgg
     1981 tgcgggcggc ggcttgcagt tgttcgtcgg tggcggccgg gcgggcgatc cgcaggttct
     2041 ccgcgatcgt ggcatggaag aggtaggtgt cctgcgagac cacggcgatg ccccgccgca
     2101 gtgaggcgag ggtgtacgcg gcggtggccg tcccggcgac ggtgaggcgg ccccggtccg
     2161 ggtcccgttg ccgcagcagc aggctcagca gggtcgactt cccggccccg gacgggccga
     2221 cgaccgccgt ggtccgcccg gcggcggcgg tgaagctgac gccgtcgagg gcgggccgcc
     2281 cgctccccgg gtgggtgaag tgcacgtcct cgaaccggat ttcgggtgcg ctcgcccagt
     2341 cggcggccac ggtgccccgg tcgggcacgg cggcttcggc ggtgcgcagg ccggctatcc
     2401 cgtcggccgc ggacaccccg agatagcccg cgtgccactc gcgggagagg tcgcggacgg
     2461 ggcggaagca ttcggaggcg aggagcagca ggaggtaggt gccggtggcg gcggtacggc
     2521 cggtggccgc cgacgagcac gccacgagga cggcggcggc cgtgccgccc tggacggcca
     2581 ggtcggtgag gccggtgtcg acgagcgaga cccggagttt ggcgacggtg gtccggtgca
     2641 gggcggccga ccgccgctcc agccgttccc gtacgcggcc caccgcaccg gtggcgcgca
     2701 gggtcggcat cccttgaagt gcctccaggt agtcggcggc gagggcttcg taggagtccc
     2761 agtgctcctt gccgcgccgc gcgagcagcc ggtcccacca gcgcggcccg aggagggcga
     2821 gcagcagggc ggggccgagg gcgagggccg cgtacggctc gacgagggcg acggcgacga
     2881 gcagcagcgg cggaacggcg caggtgatga gcgcttgggg cagatagcgc gagacgtacg
     2941 cgtcgacgcc ctcgacgccg tccaccagcg tggcgcgcac ggctccggcg cgcgcaccgg
     3001 tgatcggggt tgggccgagg gcgccgagcc gctccagcag ggtgtcgcga agcccgatcc
     3061 gaacggtggc tcccgccgtg acggcggtca ggcgctgggc gcggccgagg ccggcgcgga
     3121 ccaggacgac ggcgatgacg gcggtcagca gtggggcgag tgcggccgtc tccccccggg
     3181 cgatccgggc gagcacgagg gcgagcagga cggcctgggc gaggtgggtg gcggtgaccg
     3241 ccgcgagcag tgcggtggcg aggccgaggg gacggcgcgc ggtgttcgcg gcgcgcagga
     3301 gttcggggtg gagcatcatg ggcgttcttc ctcgccgggc ggagtcgccg gggcggcggg
     3361 tgtcgggggc gctgtcgcgg gtcccgtcgg ggcaggtggc gtcgggagac gttcctctgg
     3421 ggcgggtggc gttgaggcgg gtggtgttag ggcgggtggc gttggggcga gtgcccttga
     3481 ggcgggtgcc gtcgtgacac gcggcggtgg ggcaggcggg gttgaggcaa gcggccctgg
     3541 ggcgggtggc ctatcggccc tctgcgggtg tcggacggag cccggggcga cacggtccgg
     3601 cggtgggggc gccccgaccg ccagaccgtg cacgatccag tcgcggccgg gggcctcgcc
     3661 gagcgcggcg cccaggtccg cctgctgcca ggagccgatg ggccgcgagc gcaggcccag
     3721 tgcggtggca tgggcctgga ccactccggc cgcgtacccg gcggcgaggt ggcaggtgcg
     3781 aacagcggcc gccggggcgt caccggggca gccgtgggcg aggagcaccg cgcccgcccc
     3841 gccgatccac tgctggcccg cggcccagcg ggcgagggtg ggacgtgcgt ccccggaggc
     3901 acggacgtcg agaccacggc tgccgggagg cttggtgtac agggccgggg cgtcaccacc
     3961 gaccgccgct gtccaggcgg gtccgtccgg ccgtgctgtc cgcgcggtgg tcaggagccg
     4021 ggcgagcagg tcctcgccgg gcgggtgggt caggtcgtcg ggcggtgcgc tccggcgctt
     4081 ctccagcgcc ccgtcggtca ccggtcccgg gcggggggcc gggtgccagc tgccgccggg
     4141 caactcgggg gctcgcgcga tgtggtgcaa caggttccgt gccgccgcga gttcggtggg
     4201 cgctgcggtc tccgcgccgg gccgcgccga cggggctccg gtacggggcg ggccggccca
     4261 tgcggtcagt gtcccggggg cgtcggcgac cacgcccatg ggcgtcaacc tgacggctgc
     4321 gagcggcagt tccggctcgg ctccgggccg ggtgtccggc cggtccggag aggcgtgcag
     4381 tccggcggcg gcggagagga gggcggcgtc cgcgtcgagg cagaccagta cgtcggcggc
     4441 cgggggtccg gccagcgcca gagcggcggc ggcgtggccc gtgtccagca gcagcagcgg
     4501 ccaggcgcga tggccgtagt gcgcgacggt gcgcgacgcg gccacggtga ggacgacgag
     4561 cacacccggg gacacgccgc cgggcgccgg gccgcgccgg tgggcgcggt gggcgcgcgg
     4621 gtcgtatgcg tagcgtccgg gcggcagcga acaccccgga ccgatcagga ggtgggcgcg
     4681 caccgggtgc agggctcccg ccgaggggac ggggcgcagc cggcccggtg tgccggcggg
     4741 cgcggccagc gagagccgca ggacgcggtc caggtcgatc gtggcccggc cccccacccc
     4801 gggccgggcc tcgtacccgg ccaacggcat ccccgccccg ccccggggga gcgggcgctc
     4861 gggaacgtac ggggcgaggc ccggcgcgcg cgaggagcgg acgtccgcga gggcccggcg
     4921 caggaagccg gacgcggggc gcgtcccgga ttcgggtgcg gcggtccggg ccgaggtgtc
     4981 gggcatggcg gcgcgctcct tcacatgtgc gggggcgggg cgagggtgaa gtcacccggt
     5041 gcggcgggcg gtcgggttcg ccagccccgg gcgagcgcgg cgtccgcgaa tcgcgggcag
     5101 ccgaagtagc cgaaggccgc cggcgcgttg gggatcagcc cggagaccag tacgcgggcg
     5161 acgcgcaggc tcgtctcggc gacgtcctcc gtggtgaggt ccgcggtgat cacccggtgc
     5221 cccccggcgg cgagcgccgt atcgagcgcg gtgcggctgc cggggtcgat cgcggtgacc
     5281 gggaccgtgc cgagagcggg ttcggtgaag cgtcgggcga gcggggccat ccggtcgtcc
     5341 agccagacct ggacatgggc accgaggtcc cggacggcgg cgaactcggc cccgcagtcg
     5401 tcgagatagc gccggtcggc gcggtggtcg aggtagaggc cacgggcgag catcccggct
     5461 tcgaccgccc ggtacaccca gccgtcggcg tccaccgctc cctgggtgaa cacccaggtg
     5521 tgcacggcct ccagcacggc cttgcgggcc gcctccgccg ggtcgtaccg gcaggcgaac
     5581 ccggccgcgt agatgccgcg tacgggatcg tgcgcgaggg ccgccacaca gggggcgaac
     5641 tcggagggca tctccacgat gtgcacgtcc agcccgcagc cggccagatc atcggtgagt
     5701 ccggggacgc tggccgggtc gatgccccgg gtgggcccgt ccaggtgcca ccacagctcc
     5761 agggcgtcgc gctcgacgac ttcgaggagg ccgcgctcga cggcgtcgtc gaggccctgc
     5821 ccggtggcga tgcccgcata gttgaggtgg tgggtgcggg gcagcgaccg cagtccgccc
     5881 tggcgccagt tgaggtgggt cagcgcgacg ggggcccagc agggccgccc gttctcggtg
     5941 gccctggtcc acaacgccgt tgtgtcgggg ttgagttcgg cgtacgggaa tcccgggcgg
     6001 acgtactgcc agggggcgta cgtcggcaga gcgccgggac cgtagaggcg gtggccctcg
     6061 gcggtcagat cggcggcggt ggcccggcgg ggctcctggg ggtggccggg cggtgggagg
     6121 cggttgccgc agtagcgctc gacggcctcg gccaccgcgg cgatccacgc gccccggggg
     6181 tcgccgaacg tggtgccgag cgaaacgcgg tcggcgggcc aggcgccgag acggcgggcg
     6241 tcggcgacgt cggcggtcat cgcggtgtag cggggcggcg caccggtggg gtgctcgacg
     6301 ggcgcgacgt cgcggatgat cccgctgacg gggtccacga gggcttcgat gggcagggcg
     6361 ctggtcaacg gcatatctcc ggtgcgggct cgacgtagcg gcgtcgggcg acgacgggca
     6421 ggtggagggc gctgccccgg gggtccacgg tgcggcggga cggggcgagc cgggtggcgg
     6481 taacggggtc ctcgccggtg tgcgggttgc gggcgtgggc ggggaagtgg tgtccggcga
     6541 tctccgcgcg caatcgggtc ccggcgggca gccgacggcc cagtgtgccg agcgggacgc
     6601 tgatgtccgc ggcctcgccg ggcgggccgg tgcgccggac gatgccgaaa gcgagcggat
     6661 ccgcgcggcc ggtcgggtcg agcgcggtca ggcgtacggc ccagtcggca cagggcgtgt
     6721 cggccgtgac gttgatccgg gcgacggcgg ctcccgccag gtcgagcggg cggggcagcg
     6781 gcggcgagag gagcagacag cggtcggcac gatcgccgtc ggccgggacg gcgaggtcgt
     6841 cggagcgcac gggacggtcc gggtcggcgt tgaactcggc tccgtggagg agccgcagac
     6901 cggtgggcga gtcgaaggac cagcggctcc ccgcctccgg ccggtccgcc cccgccctcc
     6961 actccgcccc ctcctggacg gtggcgtcct gcgtggtggc agcctgcgtg atcgcggggc
     7021 ggggggtgct ccgcagccgg gtgctgtgcc agcgaccgct gtcgccgagg gcgatggccc
     7081 cgtgccgtgt cggctccagc cgcccggcga gcgccgcgcg ggcccaccgt acgtacagtg
     7141 caccgaggtt gacgcgtgcg cgcgccggtg cggcggggtc ggcggtgagg cggtggcccc
     7201 agggcccgag cagcagacgg gacggtccgc cccagccgcg ccacagggcc acggtgtcct
     7261 cggcgaatgg atcacgggtg ccgcctacgg cgagcagcgg aaggcgggcg gtggagccca
     7321 gcgcgacgag ccggcctcgt gcgcggtcgg cccagagccc ggcccaggac ggcagttcgc
     7381 gccccaggct cgcggcgagc cgctccgcga ggcgggcgac cgggaggtgt tcgagcagtc
     7441 gggggtcgtc cgccagggcg cgggtcagcg cgtccgggtc ggagtcgcga cggtcgccgt
     7501 gcgccgccca ccagccggcc cgggcccaca gccgctccgg ccccccgggc tcgcgcgccg
     7561 tctcggtgag tccgagcgcg ggcacggcgg cgatgacggc gtcggggact ccgtcgccgt
     7621 ggaggccgcc gggcgctccg tcgcggtgaa ggttgtcgag gactccgccg cggtggaagt
     7681 cgccggggtc ggcgtcgggg cccgtatcgc aggcggtttc aggggtggcg agtgcggtga
     7741 cgagggcgca gtacgcggcg taggaagcgc cggcggcgac gacctccgcg ttgctccacg
     7801 cctgtgcgcg tacccaggcg acggtggccg cgccgtccgt ttcctcgtgg tcccggtagg
     7861 ggtgccactc ccccggtgag ccgtggcggc cgcgtacgtc ctgggcgagt gcggcgaatc
     7921 cgtgcgccgc ccagccgcgc agctcggcgc ggtgggcctc gcgcccgtag ggggttctga
     7981 tcaggacggc ggggaggggg cgggtcccgt ccgggaggca tacgtcggtg gcgagcgcgg
     8041 tgccgtccgg catggggacg tacacggtaa gggtgttcac gggcgcgcct cggcggtccc
     8101 ggccgcggca cgggtccgca cagccgccgg ggcgggcagg ggcgcgacgt ccgggacggg
     8161 gagcacgggg tgctcggtga gggtgaggtc gcgcaggtcg atccggcgga gccgacggcg
     8221 caccggaaga acggtcgtcc gccccgtccc ggctccctct acctcaccgg cttcggcttc
     8281 ggcttcggct tcggcttcgg cttcggcttc ggcttcggct tcggcccagg cgatcagatc
     8341 ggcggtgagg agcgcggcga tcagggcggc cgaggcttcg gtggggtggg gtccggtgtc
     8401 gggggtccgg tgtccggccc agtacgcggc gagttcgcga tgggcggggg tggcggcgag
     8461 tctgcggaga cggatgtgac gggaggtgac gtcacccggg gccgcggcca ggggttccat
     8521 ccagctgtgg gcgccctcgc ggtggcagcg cagccaggcg atgcgccgcc cgggcagccg
     8581 gtccgccgtg tcccagagcc cttcgggcac gggcgagtcg aggcaccaca ccacggcgac
     8641 gcgcccttcg gcgccgtcgt ccggggccac ccgggccagc tccgccacac cgtccggggt
     8701 gatccggtgg acctcggccc cctccgcccc ggcgcagcgc gccaccggcg cggtgagcac
     8761 ggggtcgccg agaacatgga cggtgcggcc ggcgagcggg gcccgcggcg gggtggagag
     8821 cgcgtacccg gcggcttcga acgcctcgac gagccggccg agttcggccg tctgcgcacc
     8881 ctcgtccggc gtctcctcct ccggcgcccc ctcccccgcc agccggcgca ccaggtcctc
     8941 gccggtgaca ccgccggtgt cgatgcgcag gaactcccct ccggaggtcc ggagcacggg
     9001 ggcgccaccg ggaacggtga cgatcccggt gccgggagcg agtcgactgc gggtcatgga
     9061 atcctccgga tcggaaagcg gggacggaac gttcgggggc tgaacggggc gggcccgccc
     9121 gggatgtcac cgggcgggcc cgcccccgcg ctgtgcggga aacctgccgt cagcggcagg
     9181 cgtcgcttac ttctcggccg cggtgtcggc ctcgaccgcg tcgtcgaagg ggttctcgac
     9241 gagggcgttc gagtgggtgg cggagaggtg ggcgagctga ccctggtcgg cgatcgggct
     9301 gaacaccttg ttgttctcca tgagttgaag tctccattcg gtcggatcgg atgggtgttt
     9361 cggtcgcggc gttggtgcgt gccgcagcac agacactaat gaatatgatt ttcattccgc
     9421 aatagctgga gcggatcgag agggtgatct gggtaacaga caggccagcc gccctcgctg
     9481 tcgatcccca cccgcccctc cacgcccagg acttcggcca gcagacgccg ggtgaccacc
     9541 tcggccggag gtccgtcggc ggcgacgcga ccctcgcgca gcgcgacgat ccgatcggcg
     9601 aaccgagcgg cgtggttgag gtcgtgcagc accatcacga ccgtcagacg gcgttcggcg
     9661 cgcagccgta cgaccgtctg gagcacctcc agctggtgcc gcagatcgag ataggtggtc
     9721 ggctcgtcga ggaagagcac gcgggcgtcc tgggccagcg ccatggccag ccggacccgc
     9781 tggcgttcgc ctccggacag cgcatccacg ggcctgtcgg cccaggcggt gacgccgacg
     9841 tccgcgagcg cccgggacgt cacctcgtcg tcgccctccc gcagcatccc gagcggcccc
     9901 cgggcggcat agcgcccctg tcgaacgagt tgacgcacgg tcagccccgg tacggtgggc
     9961 gccgactgat ggagcagggc gacgcgccgg gcggcggtgc ggcggggaag ccgcgtcacg
    10021 tcgtcgcctt ccagcaggac gcgcccgccg ctcggggcga gcagtccggc ggcgagcttg
    10081 aggaaggtgc tcttgccgca gccgttcagc ccgatcaggg cgaccagttc gccggcgcgg
    10141 acgctcaggt cgaccccgcg caggaccatg cgtcccgggt agccgaaggc cagcccctcc
    10201 gcccggacga cctccgggcc gggcctcacg cccggtcccg cttccggccc ggccgcctcg
    10261 gccgggctcg actccacttg tccggtcagg ccttccgcca tgccaccctc ctcatccgtt
    10321 gtcctccact tccgtcgacg gagtcgacgg agtctgcgac gtcggcgtgt cccgtccacg
    10381 taccgctctc cgtcatcgct cgtccgcccg tcgccgtgcc acgaccatca gcagccccgc
    10441 ccccacgaaa gtggtcaggg cgccgaccgg gagggtcagc cggtccgctt cgagcgcggt
    10501 ggccagcagt cgggacagca gttgggcggc ggcgtccgcc ccgcacacca cggtcgcgcc
    10561 gagcagcgcg gcccccggaa gggtgatgcg caggtcggcc ccgaagacgg ccagcgccag
    10621 atggggcacc agcagcccca cgaagccgag cgcgcccacg gccgacacgg cgccggccgt
    10681 cagtgccacg gcgcagacga gcgccgcacc ccggcccctg ccggtggcca ggcccgcggc
    10741 agaggcctgt tcgtcgccgc agcgcaacag ggtcagcggc ccggagagca gccaggccgc
    10801 cgcaccccag aaggcggccc acggccagag cagattccag tgctgccaca cccggccctc
    10861 ggtggaaccg atcaaccact gcacgacgct gcccagttcg ccgggggcca ccagaaggac
    10921 gaccgcggtg agcccggcga gcaccgccga gacgaggacc ccgtagacgg ccgtctgctc
    10981 cgggtcgccc gcctcacgcc cggcgagcag ccacagcagg cccgctccgg cgaagccgcc
    11041 gagacaggcc gccacgacca cggccgtggg ggattcccag cccgcgaggc cgaggccggt
    11101 cgcggcgacc gcgccgagca ccgcaccggg ggtgacgccg gtgacctcgg gtccggccag
    11161 cgggttgcgc agggccgact ggagcaccag ccctgccacc ccgaggcagg ccccggcgac
    11221 cagcgccacc agcagccggg gcaaacggag ttggagcacg atgtgctcgg cggtggggtc
    11281 gccgccgccg agcagcacct cccgtacgcc ttcgggggtg acgcccctcc cggcgaacag
    11341 atcggcgcag gccaccgcgg cgacgagc
//
