LOCUS       NZ_LIVW01000001        28889 bp    DNA     linear   CON 28-MAR-2024
DEFINITION  Streptomyces sp. CB02115 scaffold1, whole genome shotgun sequence.
ACCESSION   NZ_LIVW01000001
VERSION     NZ_LIVW01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CB02115
  ORGANISM  Streptomyces sp. CB02115
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 2387836)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2387836)
  AUTHORS   Yan,X., Ge,H., Hindra,F., Yang,D., Huang,T., Crnovcic,I. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-AUG-2015) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC Genomics Workbench v. 7.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905645.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:50:42
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,651
            CDSs (total)                      :: 7,572
            Genes (coding)                    :: 7,475
            CDSs (with protein)               :: 7,475
            Genes (RNA)                       :: 79
            rRNAs                             :: 3, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1 (5S, 16S)
            partial rRNAs                     :: 2 (23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 97
            CDSs (without protein)            :: 97
            Pseudo Genes (ambiguous residues) :: 0 of 97
            Pseudo Genes (frameshifted)       :: 34 of 97
            Pseudo Genes (incomplete)         :: 79 of 97
            Pseudo Genes (internal stop)      :: 9 of 97
            Pseudo Genes (multiple problems)  :: 23 of 97
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:09:48
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 804618
            Orig. end                         :: 833507
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LIVW01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..28889
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="5"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..28889
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..28889
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:18889](-)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..18889)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     gene            complement(25..1233)
                     /locus_tag="AMK28_RS03525"
                     /old_locus_tag="AMK28_03470"
     CDS             complement(25..1233)
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1087: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007455576.1"
                     /locus_tag="AMK28_RS03525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_03470"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_073740155.1"
                     /transl_table=11
                     /translation="MSSSAPAPGIAVIGAGIGGLTLAAALARLGIGCRVFERAEQPAEA
                     GAGVQLAPNAVRLLRRLGLSDALRQYGVRPLSRDLLRWDDGRLLARTGLGEECEKLFGA
                     PYVTVHRADLHRALRDLVGPVVRTGQRLTGLAEEPGAVLLRFADGSEHRSELAVGADGI
                     RSVVREHLAADAPVFSGRRIYRGLVPVERVPELADEPRVQVWLGPGRHCVCYPVSGGRL
                     ISFAATTGGTALPGESWTAPGDRGEAAEAFQGWHPTVTRLLGAGGGIGCWALHDREPLA
                     RWSSDALTLLGDAAHPMLPFAAQGANQAIEDAFALAATLALSRGDIPEALRRYEELRIP
                     RTERLQRSARSVAVGSHLPDGPLQRARDAELASGSALEGLRWVYGHDALAAAARWTRER
                     QKA"
     gene            complement(1223..2332)
                     /locus_tag="AMK28_RS03530"
                     /old_locus_tag="AMK28_03475"
     CDS             complement(1223..2332)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019547674.1"
                     /locus_tag="AMK28_RS03530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_03475"
                     /product="3-dehydroquinate synthase II family protein"
                     /protein_id="WP_056700857.1"
                     /transl_table=11
                     /translation="MSSEKLCWLDIRSAGKARQAIVEEALHQRIDGIVAADPADLEGLP
                     PTVTKVLMPPPGKQPASYGSAGVVILAGDASARAQAAEAAPDVEFGRLVEITDAESLDA
                     AIEAARTERWSVLEFRDPTKIPLEIVIAAAADADGAIITMAKNTEEAAVIFGCLQLGSD
                     GVLMPGRSVGDATALKATAAGGTGELLLVELEVTAVAHIGMGERACVDTCSYLGKDEGI
                     LVGSHSKGMILCVSETHPLPYMPTRPFRVNAGAIHSYTLADEGRTRYLSELRAGSKVMA
                     VDTKGRTRTVAVGRVKIETRPLISIDAVAAGGQEVNLILQDDWHVRVLGPGDAVLNSTE
                     LRPGDRVLGHLPTADRHVGYPIDEFCHEQ"
     gene            complement(2304..3146)
                     /locus_tag="AMK28_RS03535"
                     /old_locus_tag="AMK28_03480"
     CDS             complement(2304..3146)
                     /GO_function="GO:0004332 - fructose-bisphosphate aldolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007455580.1"
                     /locus_tag="AMK28_RS03535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_03480"
                     /product="2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate
                     synthase"
                     /protein_id="WP_073740156.1"
                     /transl_table=11
                     /translation="MTTHQHFGRAVRLRRLFHHDPQRLMIVPLDHSLSDGPVVPRGSSI
                     DRLAGQLSGAGVDAIVVHKGSVRHIDHSRLATMSLILHLNASTAHAPDPDAKHLVTGVE
                     AALRLGADAVSVHINMGSREEARQLADLGAVADQCDRWNLPLLAMMYPRGPKITDPADP
                     ELVAHAVTLAADLGADLVKAPCLRTRAEMRDLTAACPIPLICAGGPQRDSEDEVLAFAR
                     EAVAGGAAGVAMGRNIFQSPDPGAMAARVAGVVHNRPGGTLGHIEEGHGSELRETVLA"
     gene            complement(3143..4789)
                     /locus_tag="AMK28_RS03540"
                     /old_locus_tag="AMK28_03485"
     CDS             complement(3143..4789)
                     /NRPS_PKS="Domain: AMP-binding (23-440). E-value: 8.5e-69.
                     Score: 224.0. Matches aSDomain:
                     nrpspksdomains_AMK28_RS03540_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012711.4"
                     /locus_tag="AMK28_RS03540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_03485"
                     /product="fatty acid--CoA ligase family protein"
                     /protein_id="WP_158073322.1"
                     /sec_met_domain="AMP-binding (E-value: 1.8e-70, bitscore:
                     234.5, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTFPIDVPDSWAGHEHYARRVLWRLARQPSLPTLYFQGRWLNGAT
                     LADAVRATAVGLRRAGLTPGGTVAVLTEPNHPAMLIGRYAAHLLGAAVVQVRSANPRSD
                     AFPLPAATQARILDETGTSVILVDAPQLERARALLSLTEGSPRLLGYGVGAADCPDALS
                     YRDEPLGELPAHSPDRRALVAFTSGSSGTPKSIDQTFGVWDSTVRSAASGEPDERRVFL
                     AVTPLSHTIGAMADSVLAAGGQVLLHQDFDAPKVLRAFEDHGVTDTYLAVPHLYRLTEL
                     LADAPGHEQGPGPDPVGDALWSLRRVVYSGTPAAPHRIAEALRVFGPVLVQLYGTTEAG
                     GISNLSPFDHLEPELLGSVGRPLPWVEVEVREPGTGDPVPRGEAGEIWVRASTVMDGYP
                     NDPEQTARVLRDGWLDTGDLGHWDRYGYLRLTGRSGQVIKSGGLKIYPAAVERALLSHP
                     AVRHAAVHGVRDPDRTEYVHAAVVFRAGRTSSAEELRTHVGEQLSPLHAPAEITFWDSM
                     PLNERGKPDLACLRSGNGRQAYDGAPPKGTP"
     aSDomain        complement(3470..4720)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMK28_RS03540_AMP-binding.1"
                     /evalue="8.50E-69"
                     /label="AMK28_RS03540_AMP-binding.1"
                     /locus_tag="AMK28_RS03540"
                     /protein_end="440"
                     /protein_start="23"
                     /score="224.0"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="RLARQPSLPTLYFQGRWLNGATLADAVRATAVGLRRAGLTPGGTV
                     AVLTEPNHPAMLIGRYAAHLLGAAVVQVRSANPRSDAFPLPAATQARILDETGTSVILV
                     DAPQLERARALLSLTEGSPRLLGYGVGAADCPDALSYRDEPLGELPAHSPDRRALVAFT
                     SGSSGTPKSIDQTFGVWDSTVRSAASGEPDERRVFLAVTPLSHTIGAMADSVLAAGGQV
                     LLHQDFDAPKVLRAFEDHGVTDTYLAVPHLYRLTELLADAPGHEQGPGPDPVGDALWSL
                     RRVVYSGTPAAPHRIAEALRVFGPVLVQLYGTTEAGGISNLSPFDHLEPELLGSVGRPL
                     PWVEVEVREPGTGDPVPRGEAGEIWVRASTVMDGYPNDPEQTARVLRDGWLDTGDLGHW
                     DRYGYLRLTGRSGQVIKS"
     CDS_motif       complement(3569..3652)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMK28_RS03540_0002"
                     /evalue="8.60E-08"
                     /label="NRPS-A_a6"
                     /locus_tag="AMK28_RS03540"
                     /protein_end="407"
                     /protein_start="379"
                     /score="24.5"
                     /tool="antismash"
                     /translation="PRGEAGEIWVRASTVMDGYPNDPEQTAR"
     CDS_motif       complement(4205..4249)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMK28_RS03540_0001"
                     /evalue="3.70E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="AMK28_RS03540"
                     /protein_end="195"
                     /protein_start="180"
                     /score="13.5"
                     /tool="antismash"
                     /translation="ALVAFTSGSSGTPKS"
     misc_feature    4789..4802
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.19"
                     /tool="antismash"
     gene            complement(4905..5075)
                     /locus_tag="AMK28_RS03545"
     CDS             complement(4905..5075)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015036314.1"
                     /locus_tag="AMK28_RS03545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiazolylpeptide-type bacteriocin"
                     /protein_id="WP_073740158.1"
                     /transl_table=11
                     /translation="MRSTLETMDADAMFDSFDIEELDTMEIADGVALPEMAASSLPVTC
                     CSSSSSSCCCC"
     gene            complement(5295..5459)
                     /locus_tag="AMK28_RS38630"
     CDS             complement(5295..5459)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015036314.1"
                     /locus_tag="AMK28_RS38630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiazolylpeptide-type bacteriocin"
                     /protein_id="WP_073740159.1"
                     /transl_table=11
                     /translation="MSKIMETMDVDAMFDSFDIEELETMELADGVALPEMAASTIPVAC
                     CSSSSSSCC"
     misc_feature    complement(5505..5521)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.45"
                     /tool="antismash"
     misc_feature    5686..5702
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.57"
                     /tool="antismash"
     misc_feature    complement(5687..5701)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.51"
                     /tool="antismash"
     misc_feature    complement(5688..5699)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.18"
                     /tool="antismash"
     misc_feature    complement(5737..5752)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 16.88"
                     /tool="antismash"
     gene            complement(5857..6021)
                     /locus_tag="AMK28_RS38635"
     CDS             complement(5857..6021)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019547678.1"
                     /locus_tag="AMK28_RS38635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiazolylpeptide-type bacteriocin"
                     /protein_id="WP_073740160.1"
                     /transl_table=11
                     /translation="MSKILESVDADAMFDSFDIEELGTMELADGVALPEMGASKGDFTC
                     CSSSSSSCC"
     misc_feature    complement(6068..6082)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.51"
                     /tool="antismash"
     misc_feature    complement(6069..6080)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.18"
                     /tool="antismash"
     misc_feature    6121..6134
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.12"
                     /tool="antismash"
     misc_feature    complement(6121..6136)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.47"
                     /tool="antismash"
     gene            complement(6234..6398)
                     /locus_tag="AMK28_RS03560"
     CDS             complement(6234..6398)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015036314.1"
                     /locus_tag="AMK28_RS03560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiazolylpeptide-type bacteriocin"
                     /protein_id="WP_073740161.1"
                     /transl_table=11
                     /translation="MSMAIEAMNADALFDSFDIEELDTMEVADGVALPEMGASTGNTMC
                     CSSSSSSCC"
     misc_feature    6452..6466
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.99"
                     /tool="antismash"
     misc_feature    complement(6499..6514)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 16.88"
                     /tool="antismash"
     gene            6641..8287
                     /locus_tag="AMK28_RS03565"
                     /old_locus_tag="AMK28_03490"
     CDS             6641..8287
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009306316.1"
                     /locus_tag="AMK28_RS03565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_03490"
                     /product="bifunctional
                     3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid
                     hydroxylase"
                     /protein_id="WP_073740162.1"
                     /transl_table=11
                     /translation="MNGISGSRGRSTGAPEADVLVVGYGPVGQVLSILLAQHGWRVVVV
                     ERHPEPYSLPRAVAFDAEAARTLDAVGVTGRIGDITEPSQDYVVSDAAGRQLLRIGLGG
                     SDGTGRPDSTSVHQPGLEAALAARGEELPTLRVLRGLRAVELTESGSGAELVAEDERSG
                     GQRTFTASWVVGCDGAGSFVRRSLGVGWADSGFALDWLACDVVPHRPEDFPPSNLQIAD
                     PARPRVAVTCGPGRRRWEFMRMPGEDRAEFGTEENAWRLLSMFSARPDNATLTRHATYT
                     FRARNAEHWRRGRVLLAGDAAHQMPPFAGQGMCSGFRDAANLAWKLDLVLGGRAGESLL
                     DSYEQERRAHVQHAIDLSVRLGRLICLTDPAAAADRDRAMTARPAGPARPSGPARSASP
                     LGEHLAKGFLADGGPPAGELMGQVRLTGPDGPGPADSVLGPGFVLLCRENLADTLSPAA
                     LETLRLASGRVVTVLRADAGSAPGPNTVLDTDGRCLPWLDSIPAGAVLIRPDRYLFGAA
                     PDADGLAVLIADFRRRLCPATRGPGTAAGSA"
     gene            complement(8313..9053)
                     /locus_tag="AMK28_RS03570"
                     /old_locus_tag="AMK28_03495"
     CDS             complement(8313..9053)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007451942.1"
                     /locus_tag="AMK28_RS03570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_03495"
                     /product="ABC transporter permease"
                     /protein_id="WP_073740163.1"
                     /transl_table=11
                     /translation="MSSLTLVHARYQLVELSRIPMAIIGAAFFPAASLFFFVVPNTKDD
                     PAGATLATASMVVFAAMISNLFGHGTGVAEDRSQPWDPYTRTLPIGPAVRFGSRIITGL
                     AMMLFSMFPVVIVAAFFTPATISPVRFLLAIGVVIIVSVPFTMMGLAIGYLLSTKAAIA
                     TVQLVFLPLAFAGGLLGGPGEAPGFIETIAPFVPTRGSAELMWATVGDYDINPVAMVSL
                     VVWTVGLAALAFYAYQRDEGRRYH"
     gene            complement(9087..10004)
                     /locus_tag="AMK28_RS03575"
                     /old_locus_tag="AMK28_03500"
     CDS             complement(9087..10004)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007451944.1"
                     /locus_tag="AMK28_RS03575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_03500"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_069756635.1"
                     /transl_table=11
                     /translation="MSTSPTTATARAGAPPTPAVVARAIGVTRHYGDTVALDNVDFTVR
                     EGEFIGLLGPNGAGKTTLLNSLLGLRKPTSGRIELFGGAPTNPASRRFIGVTPQESGVP
                     PTLRVAEAVDFVAAHFKETEDRDELLERFDLTKEARRQAGGLSGGQKRRLALALAFVGR
                     PRLVILDEPTTGLDVESRRMLWDRIREFHEGGGTVLLTTHYLEEIEALAKRVVVIAQGR
                     IRADDSVGAIRGMAHMQRVSMNAGPLPDLPGVISEERTEERVELMTHDADQLVRALVRQ
                     GVEFSGLAVQQATLEEAFLVISQS"
     gene            complement(10001..11026)
                     /locus_tag="AMK28_RS03580"
                     /old_locus_tag="AMK28_03505"
     CDS             complement(10001..11026)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019547685.1"
                     /locus_tag="AMK28_RS03580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_03505"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_079198904.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2e-40, bitscore:
                     136.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDTSETARAGGGAGPGGPDTVWRTWHLHVPSGDRSAHDRVVVDT
                     VGPVLHTLPGRPWFFLRYWHGGPHIRLRLGDLTDDQAASAERLLAERLVDAGRLREGET
                     AMDPADYARTAASMTTAGDQPSHQEVTGMLEPGVHRFAYHPEYERYGGRELMPGSEQLF
                     ELSSRLVLAFLRREPSTGARALLALRATVCAARALGADPAEEAAFYDHGLRAWRTWAAG
                     YGYTERQLDELYRTARPTDELRAKATGGDTPGPLAPWQTALTGLSDRIRRETSLHPAQV
                     TVSHVHMLHNRLGLRTVEEYQTYARLARLFPVRPAPEGAPPPDHSGPAQSSAVPSTEEH
                     R"
     gene            complement(11041..12525)
                     /locus_tag="AMK28_RS03585"
                     /old_locus_tag="AMK28_03510"
     CDS             complement(11041..12525)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018553604.1"
                     /locus_tag="AMK28_RS03585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_03510"
                     /product="nitroreductase family protein"
                     /protein_id="WP_107418248.1"
                     /sec_met_domain="PF00881 (E-value: 4.6e-06, bitscore: 23.8,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDTSDRGGPGSPIPDDADVMSRDMRWFTYATGLGVRVEAEAVPE
                     PRPDTEVAPALPEAALGDRTPLPRGTTELLERAPYPHGRADAPRARADALGHALVAGFG
                     LQRREPENPFNDHRPYPSVRAKFPVQVLVRDGRQRRVLDLYRHALTGVGRQDGAAGPLE
                     VALAGRYTRLPDTYRWFRSSLIGLELGVNLRQLCLGMELFGLSGKLRLPDRNAAGLLTD
                     FGLTPESEWSLPLTVALEDGGPPVAAAPAERAADPVLDGILTVNRAQDFTGSAAPLGPS
                     VPAGLPRDGALSWAEVLWRRSAGRMPRGMYGMTGRRRPVPERTLREAVSWLSVPPPGPH
                     LAAAWEELRLTAVFQGIEGHADGVWHLRDGRPTLHRARPGAAAELETHYGYPVTPYAGG
                     DVRHASAVWFLSAHPRRLVDRLGPGGFTAAQYAAGWAAQGISLAAAATGLYARPARAFQ
                     EVPTRQLLGLDPDEMIVCAAITGTPRFEGLLCDLRL"
     gene            complement(12608..14539)
                     /locus_tag="AMK28_RS03590"
                     /old_locus_tag="AMK28_03515"
     CDS             complement(12608..14539)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007451953.1"
                     /locus_tag="AMK28_RS03590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_03515"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_073740165.1"
                     /sec_met_domain="YcaO (E-value: 9.3e-66, bitscore: 219.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAENPTTVACAPALSDAEGTDWRAVLEPLGASGDGTVGANLGWDL
                     DWEREQLRSADGREHLSVRVYGDEVLVGPRWVPGTDSGCAGCAELRSRLVIDHPLTDDL
                     TRPTSRVAPRRPFLPELTRAALARLAVRPLGPGELYAVGSRGTRTHRIPRHFACPLCAP
                     EIPERPVGRPPQPLALKSRPAAADNPGRAAAGAGLVRPGALRSRLVDPRFGPVLAQQRE
                     LLAPFAMSMALQPDAVALGYARETTFAKADPIAILEVYERLSGFPHQAPLVEGVSYAEL
                     VSAEGGAEVAVRPAAFGEYTEEQAARPTARIERVTDETPMDWAWGHDLADGRPRLVPAE
                     LAFFQYDYRYGRDQRAARRHGAAPRRHLYQESSSGCAVGSCLEEAALYSLLELAERDAF
                     LISFHRALPLPEITHSSITDPVVRGLLATAASRGFRIHLLRATQDIDLPVVWAMAVNTR
                     APFPATFSAAGSGIDPVSAVRGALWEVVQMATERMDWDRSEAEPMLADPWLVDEMDDHL
                     RLYALPEMKERVTSVLGGPGMSLSEAFAGWPDRLEQVAGGDVRGALDYIRGRYASAGLD
                     RIVLVDSTTRDHADIGLAAAKAVVPGIVPMCFGQAQQRVAGLPRLEAALAGTPSGELSP
                     PYDPHAFP"
     gene            complement(14532..16349)
                     /locus_tag="AMK28_RS03595"
                     /old_locus_tag="AMK28_03520"
     CDS             complement(14532..16349)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thiopeptide_F_RRE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMK28_RS03595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AMK28_03520"
                     /product="hypothetical protein"
                     /protein_id="WP_073740166.1"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 5.1e-09,
                     bitscore: 33.0, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLRARPHLHYAPVSEGVYFNGPRTQFVISGPQLLYRVADTCVPL
                     LEAGTTEDELVTALGSERARPVVRRIVDELRARDLLLDLGALTVPEPSAEIRARYPEAL
                     AHLETECADPYAVFQRLRTTEVLLCGPADAVLPAARGLHRAGITGLTLATPDFDAAAAT
                     TSRLGMRLLPLSDSASLPDPGDLPVPPDAALYCPGADDGVTPEALTALLPEGAPLVPVR
                     WDGLVAAVGPAAPGAVSLPGSAALVRRAARWAVDEATAPAPHPTAAALAGALAGQLLFD
                     TLAGIAPPGEAHVLHGEELTADRVSLAAPGTASGEAAERRFLTAAPVAGAEPVPPPTPD
                     EAVEAVTALTGRWTGPFALLGGEELPQMPLALRETADRDGGAGSVVAWAEEQRTATVAV
                     ALAALRAACPTPGAAAAGLTEEHWLLDGALRLMASEAVPYATRAVGAVEARSAPLLRML
                     EEEGMPDPVLTLLRHPGLDWTLAEVRTSGGPQPWTGRSWGRDETEAVHRALATALARHQ
                     AHGVPGAGPLAEGVHTDALLFADASAQAALRKQIADAAAAAGLRYEGTPRRPDPVTGAL
                     PLWSGGVRAVPLDGEPHAAEESAEETAHG"
     aSDomain        complement(16104..16349)
                     /aSDomain="Thiopeptide_F_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing F protein in a thiopeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_AMK28_RS03595_Thiopeptide_F_RRE.1"
                     /evalue="6.70E-11"
                     /identifier="RREFam004.1"
                     /label="AMK28_RS03595"
                     /locus_tag="AMK28_RS03595"
                     /protein_end="82"
                     /protein_start="0"
                     /score="33.0"
                     /tool="antismash"
                     /translation="MTLRARPHLHYAPVSEGVYFNGPRTQFVISGPQLLYRVADTCVPL
                     LEAGTTEDELVTALGSERARPVVRRIVDELRARDLLL"
     gene            complement(16346..18889)
                     /locus_tag="AMK28_RS03600"
                     /old_locus_tag="AMK28_03525"
     CDS             complement(16346..18889)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: Lant_dehydr_N"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007451956.1"
                     /locus_tag="AMK28_RS03600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_03525"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_073740167.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 4.6e-13, bitscore:
                     45.1, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDTAEPLWMLRLNPLRRRRLADPGLLAALRTLDVATTEVRELAE
                     RCSEALYEMIGATTDREARGPLIVLRRAIHNDTAPRPALLVDHPLVARWWEARQRREAL
                     AADVVGHYPRAVDAERGTLAGLLGDESLRHSMTLVAPEAAAGAGRYRAAVAATEPVPTR
                     LRKSERGLVQYVTRAMIRTSPMARFTAIGLAVPGPDGPGPDAPEFGRVVPFQGLDRVML
                     DYVLGGLHTSGGDLTPDTLLQLPPTSELSAEGDLLYFLQPGADGGVRRLSAKVTGAVGL
                     LVAAVAVGPRRAADVAADFAARSGCTPELARQALARAVGAGILCTRSRPEDGAADFPDL
                     LDPAGLTVPETARRLLEQTGAELRGLADNSADERPEALSRLRDTLVTLSREAGRPAQIL
                     IEEDAVLEDVRVSTADWRSQLDDLAAGVALLSVFDWMHDIRALLSAVFVERFGVGAEVP
                     LSDHADYLSAETYRRAYRLPENEPPGELGPADRSLDRLYALRANIVDTAIAGIDRAVAA
                     DEAVSWSASQALDLTTGLPDRFRTGDLRYGVLTQTWRRQLLFNEAYAGHGMLYGRFLGP
                     DRALGGRALPHFREQLRARYAEQDGRLVEDPGLHRLNVNAHPPVLPDRLGPDDWFRLRL
                     RHDPDTDALGIVDPDGRPLHMLSLGTGHPERLPAPLRLANWLYSGGVLREPFVAIRHAE
                     RQWDGDRTRACPRFQVGSAMLARRRWYGGRELDEAVAAGPAEHDRLLALARWRNRHGVP
                     EEVVLKPPPGDGSGEGQATGAGQAAGEGRKKKPQYVDLGSALSVRVLPRMRERGDAAYV
                     EEALPRVADSPHALEWIVDIGRAPDGPFQYGGKTR"
     gene            complement(18886..20031)
                     /locus_tag="AMK28_RS03605"
                     /old_locus_tag="AMK28_03530"
     CDS             complement(18886..20031)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007451957.1"
                     /locus_tag="AMK28_RS03605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_03530"
                     /product="hypothetical protein"
                     /protein_id="WP_079198906.1"
                     /transl_table=11
                     /translation="MITDTAAAGPDMSEAAGVRLYSRVPITPRWLAKTVLPVSRRLRED
                     HRAALLHLRRGWRYGPHIDIVARSVPGRPALDWAGIAAALDAGPAEGPAVTDEETYLAQ
                     AREMGRLEGIAPPYLPMREHGATEALSLSSVETWPQPLQDLRELALDQLDRPLTTTVEQ
                     LAGEPREAPVRIMEAFAALAAAHQHGAGNGAFSMRSHAEAFFAWAAARKDPRPAFAQRL
                     AADAPRLRPVVERALSGTPDHGTSAWARAFAYSMGAFDATVAQGRLTLDDVDGLGAGFD
                     LATMGPPGGDGRVSTEPSAFHRTMEESGVIASPPQWFASYRLLVNLFYQQLPLLGVPPM
                     HRYYFCFAVAELVDDVLGSSWQDRLEQTRQEMAQATAGAAE"
     misc_feature    20017..20032
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.65"
                     /tool="antismash"
     misc_feature    20027..20040
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.81"
                     /tool="antismash"
     misc_feature    20110..20126
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 21.74"
                     /tool="antismash"
     gene            20348..21085
                     /locus_tag="AMK28_RS03610"
                     /old_locus_tag="AMK28_03535"
     CDS             20348..21085
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018891726.1"
                     /locus_tag="AMK28_RS03610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_03535"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_338015623.1"
                     /transl_table=11
                     /translation="MVTQQRPSTVYSTEHAEIYDFIHAARGRDWSAEADGITRLIRERC
                     PEAGSLLDVACGTGAHLERFAEHFGTVAGVELSPEMRRTATRRVPAARVHEGDMREFEL
                     GRTFDAVLCMCFSLGYMSTVEELRRSAATLVRHLVPGGVLVAEPWWFPEQFIDGFISAS
                     LAQEEGRAVSRLSHSVRDGRISRMTVRYTVAETTGIREFTEYETYSLFTQEEYLDAFRQ
                     AGCEMEFLSDWPNGRGLFIGVRA"
     gene            21328..21969
                     /locus_tag="AMK28_RS03615"
                     /old_locus_tag="AMK28_03540"
     CDS             21328..21969
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF017534.4"
                     /locus_tag="AMK28_RS03615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_03540"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_007446992.1"
                     /transl_table=11
                     /translation="MSEPSDRIAGVGARADSGVEVFERHYAGEPGAGWEIQRPQTVLVR
                     LAEEGALRGRVLDVGCGSGDNALLAAEHGLETTGVDAAPSAISLAVGKARERGLKARFL
                     EWDALDLAALGEQFDTLIDVGLFHCFAPEDRPLVARSMASVVPPGGRCFLMCFSDRQPG
                     TWGPRRVPEQAVRESFTGAGWRVDTLEAAELDVAFSPGVAQAWFAAMTRL"
     gene            21992..23296
                     /locus_tag="AMK28_RS03620"
                     /old_locus_tag="AMK28_03545"
     CDS             21992..23296
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062: glycosyltransferase, MGT family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF044385.1"
                     /locus_tag="AMK28_RS03620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_03545"
                     /product="nucleotide disphospho-sugar-binding
                     domain-containing protein"
                     /protein_id="WP_073740168.1"
                     /sec_met_domain="MGT (E-value: 1.2e-116, bitscore: 387.2,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLFCTWPAAAHLYPSVPMARALHDAGHEVRVISHPSLLDTINA
                     TGLTGVSLGDEQTLPQPLGAGRPLSPDTYADLVRITKSLELDGYERYVWTYYRDYMLPA
                     VRDFQPEGAPAGEPQNALDALVGFCRSWRPDLVLWDPTMPAAGVAARVSGAAHARILWG
                     PDLFGWAHEQYTRCRKLSGDALLPEDPMTSSVRPMAERYGLPMTDELLFGQWTVNPVLE
                     RMRLPTVKRTVSMRWQAYTGPAVLPDWLREPPARPRVAITLGSSIRAWGRDSALLVNRV
                     LEMVDGLDVEAVATLDASQLAVADRIPDNVRTVDYVPLTELLPTCSAVIHHGGHGSFGA
                     ALVNRIPQFVVMDPGYPMEAPITGRFLSESGVGTGVRVDRHTGAELRAGLSRLLTAPSF
                     RDAAAELYTDLLTAPEPSEIIPVLERLTRHHQSRD"
     gene            23342..24493
                     /locus_tag="AMK28_RS03625"
                     /old_locus_tag="AMK28_03550"
     CDS             23342..24493
                     /EC_number="2.6.1.-"
                     /GO_function="GO:0008483 - transaminase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_5 (32-160). E-value: 1.8e-12.
                     Score: 38.8. Matches aSDomain:
                     nrpspksdomains_AMK28_RS03625_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007446988.1"
                     /locus_tag="AMK28_RS03625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_03550"
                     /product="DegT/DnrJ/EryC1/StrS family aminotransferase"
                     /protein_id="WP_073740169.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 6.8e-90,
                     bitscore: 298.9, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 3.2e-07, bitscore:
                     26.8, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 8.3e-10, bitscore:
                     35.1, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINVFQPSLGEAELLALSEVFASNWLGHGPRTDEFEARFADHIGV
                     EPDRMVFLNSGTAGLFLATELLDLGPGDEVVLPSVSFVAAANAIAATGARPVFCDVDPH
                     GLHPTVEHVERAMTPRTRAVIVLHYGGYPGEVAGIAALCRQRGVPLVEDAACAVASTID
                     GRACGTFGDIALWSFDAMKVLVTGDGGMLYVRDPQLARRARVLAYHGLEQPSGFAHAKV
                     SERWWELDVRSFGRRVIGNDLTAALGTVQLGRLPANVARRREVATAYDTLLANTPGVRL
                     PPPLPEGHRSSYYFYWVQMDPLIRDRVAATLLAQDIYTTFKYPPLHRVPAYGDRATDLP
                     GTDLATDSTLLLPLHQALSDADIRTVANALCEAVTHHLALAGA"
     aSDomain        23438..23821
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMK28_RS03625_Aminotran_5.1"
                     /evalue="1.80E-12"
                     /label="AMK28_RS03625_Aminotran_5.1"
                     /locus_tag="AMK28_RS03625"
                     /protein_end="160"
                     /protein_start="32"
                     /score="38.8"
                     /tool="antismash"
                     /translation="DEFEARFADHIGVEPDRMVFLNSGTAGLFLATELLDLGPGDEVVL
                     PSVSFVAAANAIAATGARPVFCDVDPHGLHPTVEHVERAMTPRTRAVIVLHYGGYPGEV
                     AGIAALCRQRGVPLVEDAACAVAS"
     gene            24639..25706
                     /locus_tag="AMK28_RS03630"
                     /old_locus_tag="AMK28_03555"
     CDS             24639..25706
                     /EC_number="2.7.7.24"
                     /GO_function="GO:0008879 - glucose-1-phosphate
                     thymidylyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0000271 - polysaccharide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007446987.1"
                     /locus_tag="AMK28_RS03630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_03555"
                     /product="glucose-1-phosphate thymidylyltransferase"
                     /protein_id="WP_073740170.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 3.5e-14, bitscore:
                     50.4, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKALILAGGLGTRLRPFTETMPKQLIPIANQPVLEHVLENLRALG
                     VREICVVVGAWGPDIAARIGDGSRFGARITYLTQQRPLGLAHCVAIARPFLGDDDFVMY
                     LGDNVVQDGIAGPAEEFRARRSDAHMVVARVADPRAFGVAELDALGRVRRLVEKPRLPL
                     SDLALIGVYFFRPAIHRAVAAIGPSARGELEITDAVQWLVDRGGSVTAGEYTGYWKDTG
                     RVEDVLDCNRRLLDSLARGVHGTVDSASRLTGPVHIAPGATVLRSVITGPVIVGPGSRV
                     EDCRIGPGTSIGGDCVLRGTELENSIVMDGAWVTERTGASDLLIGRSMRIGSDSPSVPP
                     PPELAANGARTGGTR"
     gene            25703..26695
                     /gene="rfbB"
                     /locus_tag="AMK28_RS03635"
                     /old_locus_tag="AMK28_03560"
     CDS             25703..26695
                     /EC_number="4.2.1.46"
                     /GO_function="GO:0008460 - dTDP-glucose 4,6-dehydratase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009243 - O antigen biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0019305 - dTDP-rhamnose biosynthetic
                     process [Evidence IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (4-187). E-value: 1.1e-18.
                     Score: 59.1. Matches aSDomain:
                     nrpspksdomains_AMK28_RS03635_NAD_binding_4.1"
                     /codon_start=1
                     /gene="rfbB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007446986.1"
                     /locus_tag="AMK28_RS03635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_03560"
                     /product="dTDP-glucose 4,6-dehydratase"
                     /protein_id="WP_073740171.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 7.5e-25, bitscore:
                     84.6, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 2.5e-18,
                     bitscore: 63.2, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 4e-17, bitscore:
                     59.1, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRILVTGGAGFVGSHYVRTMLAQGYPGYERADVTVLDKLSYAGNA
                     ENIPIGHPRLRLVKGDICDAPLLNELLPGHDAVVHFAAESHVDRSLDAPAVFTRTNVVG
                     TQTLLDACLNAGVERVVHISTDEVYGSIGEGSWHEESPLLPNSPYAASKAAADLTVRAY
                     WRTFGLDVSITRCSNTYGPYQHPEKAIPRFTTNLLEGEPIPLYGSGRNVRDWIHVDDHA
                     RAVQLVLTKGIAGGIYHVGGGHELTNIELAEQLLALCGADRSMIRHVTDRKGHDLRYSL
                     DGSKARTELGFTPRVGFGEGLAATVDWYRENTAWWKAAKGQAADTEDRS"
     aSDomain        25715..26263
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMK28_RS03635_NAD_binding_4.1"
                     /evalue="1.10E-18"
                     /label="AMK28_RS03635_NAD_binding_4.1"
                     /locus_tag="AMK28_RS03635"
                     /protein_end="187"
                     /protein_start="4"
                     /score="59.1"
                     /tool="antismash"
                     /translation="VTGGAGFVGSHYVRTMLAQGYPGYERADVTVLDKLSYAGNAENIP
                     IGHPRLRLVKGDICDAPLLNELLPGHDAVVHFAAESHVDRSLDAPAVFTRTNVVGTQTL
                     LDACLNAGVERVVHISTDEVYGSIGEGSWHEESPLLPNSPYAASKAAADLTVRAYWRTF
                     GLDVSITRCSNTYGPYQHPE"
     gene            26692..27999
                     /gene="rfbH"
                     /locus_tag="AMK28_RS03640"
                     /old_locus_tag="AMK28_03565"
     CDS             26692..27999
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rfbH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007446985.1"
                     /locus_tag="AMK28_RS03640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AMK28_03565"
                     /product="lipopolysaccharide biosynthesis protein RfbH"
                     /protein_id="WP_073740172.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1e-97, bitscore:
                     324.6, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDEHRTRVLEEARKHHQSVRDSGEFVPGTTEIWPSGAVLDEDDR
                     AALVEAALDLRIAAGPLSKRFESEFARLLKRRKAHLTNSGSSANLLALTAYTSPQLGER
                     RLLPGDEVITVAAGFPTTVNPILQNGLVPVFVDIELGTYNTTADRVAAAIGPKTRGIMI
                     AHALGNPFEVEEIAQLAADHGLVFVEDNCDAVGTTYRGRLTGTFGDISTVSFYPAHHLT
                     MGEGGIVTTSDLKVARIVESLRDWGRDCWCEPGHSDTCLKRFDHQLGALPAGYDHKYIF
                     SHVGYNLKSTDLQAALGLSQLRKLDGFIAARRHNWRRMREGLDGVRHLLLPEATAGSDP
                     SWFGFVMTVGPDAPFTCGELTGYLEKRKIGTRRLFAGNLTRQPAYHQQPHRVVGELTNS
                     DIVTERTFWTGVYPGLTDEMTDYVIASVREFVAGRR"
     misc_feature    complement(28750..28765)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.54"
                     /tool="antismash"
ORIGIN
        1 acgcgcggcc cggatcccgc ccgctcacgc cttctgccgc tccctggtcc accgtgccgc
       61 ggcggccagg gcgtcatggc cgtacaccca gcgcagcccc tccagcgccg aacccgaggc
      121 cagctccgcg tcgcgcgccc gctggagcgg tccgtccggc agatgcgaac cgaccgccac
      181 ggaccgggcc gaccgctgca ggcgctcggt ccgcgggatc cgcagctcct cgtagcggcg
      241 cagcgcctcc gggatgtcgc cgcgcgacag cgccagcgtc gcggccagcg cgaaggcgtc
      301 ctcgatcgcc tggttggcgc cctgcgcggc gaacggcagc atcgggtgcg ccgcgtcgcc
      361 gagcagggtg agggcgtcgg acgaccagcg cgccagcggc tcgcgatcgt gcagcgccca
      421 gcagccgatg ccgccgcccg ccccgagcag ccgggtgacc gtggggtgcc acccctggaa
      481 ggcctcggcc gcctcgcccc ggtccccggg ggcggtccag gactcgcccg ggagggcggt
      541 accgcccgtg gtggccgcga agctgatcag ccggccaccg gagaccggat agcagacgca
      601 gtgccggccg ggtcccagcc acacctggac gcggggctcg tcggccagtt ccggcacccg
      661 ctccaccggc accagacccc ggtagatccg tcggccggag aagaccgggg cgtccgcggc
      721 gagatgttcc cgtaccaccg agcggatgcc gtccgcaccg accgccagct ccgatcggtg
      781 ctccgagccg tcggcgaagc gcagcaggac cgcgccgggc tcctccgcca gcccggtcag
      841 ccgttggccg gtccgtacca ccgggccgac caggtcacgg agcgcccggt gcaggtccgc
      901 gcggtgcacg gtgacgtacg gcgcgccgaa cagcttctcg cactcctcgc cgagcccggt
      961 cctggccagc agccgcccgt cgtcccagcg cagcagatcg cgggagagcg ggcggacgcc
     1021 gtactgccgc agggcatcgg agagccccag acggcggagc agccggaccg cgttcggcgc
     1081 caactgcacc ccggcgccgg cctcggcggg ctgctcggca cgttcgaaga cgcggcagcc
     1141 gatgcccagc cgcgccagtg cggcggccag ggtgaggccg ccgatgcccg cgccgatcac
     1201 cgcgatgccc ggcgccgggg cgctactgct catggcagaa ctcgtcgatc gggtagccca
     1261 catggcggtc ggcggtcggc agatgcccca gcacccggtc cccggggcgg agttcggtgc
     1321 tgttcagcac ggcgtccccc ggtcccagca cccggacgtg ccagtcgtcc tggaggatca
     1381 ggttgacctc ctggccaccc gcggcaaccg cgtcgatgga gatcagcgga cgcgtctcga
     1441 tcttgacccg ccccaccgcg accgtccggg tccggccctt ggtgtccacg gccatcacct
     1501 tgctcccggc cctcagttcg ctgaggtagc gggtgcgtcc ctcgtcggcg agggtgtacg
     1561 agtggatggc gcccgcgttg acccggaagg ggcgggtggg catgtacggc agcggatggg
     1621 tctcactgac gcacaggatc atgcccttgg agtgcgagcc gaccaggatg ccctcgtcct
     1681 tgcccagata ggagcaggtg tccacgcagg cgcgctcacc catgccgatg tgggccacgg
     1741 cggtgacctc cagctccacg aggaggagtt cgccggtgcc gccggccgcg gtcgccttga
     1801 gcgcggtggc gtcgcccacg ctccggccgg gcatcagcac gccgtcggag ccgagttgga
     1861 gacagccgaa gatgacagcg gcctcctcgg tgttcttcgc catggtgatg atggcgccgt
     1921 cggcgtcggc ggcggcggcg atcacgatct ccagcgggat cttggtcggg tcccggaact
     1981 ccagcacgct ccagcgttcg gtgcgggccg cctcgatggc ggcgtccagg ctctccgcgt
     2041 cggtgatctc caccagccgc ccgaactcca cgtcgggagc ggcctcggcg gcctgtgccc
     2101 gggcggaggc gtccccggcg aggatgacga ccccggcgga gccgtagctc gcgggctgct
     2161 tgcccggcgg aggcatcagc accttggtga cggtcggcgg cagcccctcc agatcggccg
     2221 ggtcggcggc gactatgccg tcgatccgct ggtgcagcgc ctcctccacg atggcctgcc
     2281 gggccttgcc ggccgaacgg atgtcaagcc agcacagttt ctctgagctc actgccgtgc
     2341 ccttcctcga tgtgaccgag cgtgcccccg gggcggttgt ggacgactcc agccacccgg
     2401 gcggccatcg ccccggggtc gggggactgg aagatgtttc tgcccatcgc gaccccggcc
     2461 gcgccgcccg cgacggcttc acgggcgaag gccagcacct cgtcctccga gtcgcgctgc
     2521 ggaccgcccg cgcagatcag cgggatcggg caggccgcgg tgaggtcccg catctccgcc
     2581 cgcgtgcgca ggcagggggc cttcaccagg tcggcgccca gatcggccgc gagggtgacg
     2641 gcgtgggcga ccagttcggg gtcggcgggg tcggtgatct tcggcccccg cgggtacatc
     2701 atcgccagca gcggaaggtt ccagcggtcg cactggtcgg ccaccgctcc gaggtcggcg
     2761 agctgccgcg cctcttcccg cgaacccatg ttgatgtgca cgctcaccgc gtccgcgccg
     2821 aggcgcagcg ccgcctccac cccggtgacc aggtgcttgg cgtccgggtc cggcgcgtgc
     2881 gcggtgctgg cgttgaggtg caggatcagg gacatcgtgg ccagccggga gtggtcgatg
     2941 tggcggacgc tgcccttgtg caccacgatc gcgtccaccc cggctccgga gagctgcccg
     3001 gcgagccggt cgatgctgct gccgcgcggc accaccgggc cgtcgctgag cgagtggtcg
     3061 agcgggacga tcatcagccg ctgggggtcg tggtggaaca gccggcgcag ccgcacagcg
     3121 cggccgaagt gctggtgtgt ggtcatggag ttcccttcgg cggtgcaccg tcgtacgcct
     3181 gccggccgtt accggagcgc agacaggcca ggtcgggctt gccgcgctcg ttgagcggca
     3241 tcgagtccca gaacgtgatc tcggcgggag cgtgcagagg ggagagctgc tcgccgacgt
     3301 gggtgcgcag ttcctccgcg gaggaggtcc ggcccgccct gaacacgacg gccgcgtgga
     3361 cgtactcggt ccggtcggga tcccgtacgc cgtggacggc cgcatgccgt accgccgggt
     3421 gggagagcag cgcgcgctcc accgcggcgg gatatatctt caggccgccg gacttgatga
     3481 cctgcccgct gcggccggtc agccgcagat agccgtagcg gtcccagtgg ccgaggtcgc
     3541 cggtgtccag ccagccgtcc cgcaggacgc gggcggtctg ctccgggtcg ttcgggtagc
     3601 cgtccatgac cgtggaggcg cgtacccaga tctccccggc ctccccgcgc ggcaccgggt
     3661 cgccggtgcc gggctcgcgc acctccacct ccacccaggg cagtggccgc cccacgctgc
     3721 ccaggagttc gggttccagg tggtcgaacg ggctcagatt gctgatgccg ccggcctcgg
     3781 tggtgccgta cagctggacg agcaccggac cgaacacccg cagggcctcg gcgatccggt
     3841 gcggcgcggc gggggtgccg ctgtagacga cgcggcgcag cgaccacagg gcgtccccga
     3901 cggggtccgg gccggggccc tgctcgtggc ccggtgcgtc ggccagcagt tccgtgagcc
     3961 ggtacaggtg cgggacggcc agataggtgt cggtgacgcc gtggtcctcg aaggcccgca
     4021 gcaccttcgg agcgtcgaag tcctggtgca ggaggacctg gccgccggcg gccagcaccg
     4081 agtccgccat ggctccgatg gtgtggctga ggggcgtcac ggcgaggaac acccgccgct
     4141 cgtccggttc accgctcgcc gcggaccgga cggtgctgtc ccagaccccg aaggtctgat
     4201 cgatgctctt cggcgtaccg ctgctcccgc tggtgaaggc caccagggcg cggcggtcgg
     4261 gggaatgggc ggggagttcc ccgagaggct cgtcccggta ggacagcgcg tcggggcagt
     4321 cggcggcgcc gactccgtat cccagcaggc gggggctgcc ctcggtcagc gacaacaggg
     4381 cgcgggcgcg ctccagttgg ggggcgtcga cgaggatcac ggacgtgccg gtctcgtcga
     4441 ggatccgcgc ctgggtggcg gcgggcagcg ggaacgcgtc cgagcggggg ttggccgagc
     4501 gcacctggac gaccgcggcc cccaggaggt gagcggcgta gcggccgatc agcatcgcgg
     4561 ggtggttggg ttcggtgagc accgccaccg tgccgccggg ggtcagcccg gcccgccgca
     4621 ggcccaccgc ggtcgcgcgt accgcgtcgg ccagcgtcgc gccgttcagc caccggccct
     4681 ggaagtacag ggtgggcaga gagggttggc gggccagccg ccacagcacg cgccgcgcgt
     4741 agtgctcatg tccggcccag gagtcgggca catcaatcgg gaatgtcacg accatccgtt
     4801 cggggccggg cgccgggccc gccctccgct gggcggacca cccggtggtg ccgcctgcgc
     4861 ggtgggcgct gcacccgccg cgcaggcggc actgcgccgc gggatcagca gcagcagcag
     4921 gaggacgagg aagaggaaca gcaggtcacg ggcaggctcg acgcggccat ttccggcagc
     4981 gcgacgccgt ccgcgatctc catcgtgtcc agctcctcga tgtcgaagga gtcgaacatc
     5041 gcgtccgcgt ccatggtctc cagggtcgat ctcatcttgt gtgtaccccc aagctcttgt
     5101 tccgccggcc gggagaccgg cggtgcgtgt gatgtcccac cggtacccgg cacgcgatga
     5161 cccgtgaccg ggcgccgaca tcggtcggct tcccgccgaa aacgaggcgg cctccgccga
     5221 tgctcacagc tcgccggtgg tggcgctgtc cgcgggtcgg gagacccgtc gcgcagacag
     5281 ctggtgtccc tacctcagca gcaggaggac gaggaggagg aacagcaggc gacgggtatg
     5341 gtcgatgcgg ccatctcggg cagcgcgacg ccgtccgcga gctccatcgt ctccagctcc
     5401 tcgatgtcga acgagtcgaa catcgcgtcc acgtccatgg tttccatgat cttgctcatc
     5461 tcggtgtacc cccaagctcc ggcccgccgg ccgggagacc ggcggtgcgt gtgatgtcca
     5521 accgctaccg gcacacgatc gccctccggg ccggcgctga acgtgatcag cgattaccgc
     5581 cggacagccg cctgccgaaa gcctgttgcg cgggtggtgc tgtctgccgc cgggtcggcg
     5641 gcaggatgag gaggagaacg agcggaacag ctcacgagac cggcggtgca tacgatttcc
     5701 aaccggaacc cggcacgcaa tgacccgtga ccgggcgctg acatttgtca gcgtttcccg
     5761 acggaaacga aatggcctcc gccgatgctc aatgctcgtc ggtggcgctg cctgcgcgtc
     5821 gggagacccg tcgcgcagac agctggtgtc cctacctcag cagcaggagg aggacgacga
     5881 ggagcagcag gtgaagtcac ccttcgaggc gcccatctcg gggagggcga cgccgtccgc
     5941 gagctccatg gtgcccagct cctcgatgtc gaacgagtcg aacatcgcgt ccgcgtccac
     6001 ggactccagg atcttgctca tcttggtgta cctccaagct ctggcccgcc ggccacggga
     6061 ccgacggtgc atacgatttc catccggaac ccgacacgca attacccttg gcgcggcgct
     6121 gatatttgtc atcaattcct gccggacaac cgcctgccga gcatgcgctt cacctcgatg
     6181 acgctgcctg cgcgccggga gaccccgccg cacggacagc cggcgtccct acctcagcag
     6241 caggaggagg acgacgagga gcagcacatg gtgttgccgg tggaggcgcc catctcgggc
     6301 agggcgacgc cgtcggcgac ctccatggtg tccagctcct cgatgtcgaa ggagtcgaac
     6361 agggcatccg cgttcatcgc ctcaatggcc atgctcattg acttgatttc ccttcttgat
     6421 taagactgcc attcggtaga agtggcacca tggataattt cggtcacttc aggcgctggc
     6481 aatctctcgc gaagcggcgc tgacatttgt caccagcctc tgcctggaag ccgatcgaag
     6541 gggcacaaat gtcgctttga tgaatcggta cggtgggcct cgattatcac ggttgcccgc
     6601 gtacggcccg aacaccatgg gtattcagga caggagaagc atgaacggga tatctgggtc
     6661 acgcggtcgg agcaccggcg ctccggaggc cgatgtcctg gtcgtcggct acgggccggt
     6721 ggggcaggtg ctgtccatcc tgctggccca gcacgggtgg cgggtcgtcg tcgtcgagcg
     6781 ccatccggaa ccgtacagtc tgccgcgagc ggtggcgttc gacgccgagg ccgcccggac
     6841 gctcgacgcc gtcggcgtca ccggccggat cggggacatc accgaaccct cgcaggacta
     6901 cgtggtcagc gacgccgccg gacggcagct cctgcggatc ggtctgggcg gctcggacgg
     6961 gacgggccgg ccggactcca cctccgtcca ccagccgggt cttgaggccg cgctcgcggc
     7021 ccgcggcgag gaactgccca cgctgcgcgt gctccgcggc ctgcgcgccg tggagctgac
     7081 cgaatccggc tccggcgccg agctggtcgc cgaggacgaa cgcagcggcg ggcagcggac
     7141 cttcaccgcc tcctgggtgg tgggctgcga cggtgcgggc agcttcgtgc ggcgctccct
     7201 gggcgtcggc tgggccgact ccggcttcgc cctggactgg ctggcctgcg atgtggtgcc
     7261 gcaccgcccg gaggacttcc cgccgtccaa cctccagatc gccgatcccg cccggccccg
     7321 ggtggccgtc acctgcggac cgggccgccg ccgctgggag ttcatgcgga tgcccgggga
     7381 ggaccgggcg gagttcggca ccgaggagaa cgcctggcgg ctgctgtcga tgttctccgc
     7441 caggccggac aacgccacac tcacccgcca cgccacctac accttccggg cccgcaacgc
     7501 cgagcactgg cgacgggggc gggtgctgct ggccggggac gcggcccatc agatgccgcc
     7561 gttcgccggc cagggcatgt gctccggctt ccgggacgcc gcgaacctcg cctggaagct
     7621 cgacctggtc ctgggcggca gggccgggga gtccctcctc gacagctacg agcaggagcg
     7681 ccgcgcccac gtccagcacg cgatcgacct gtccgtgcgg ctcgggcgcc tgatctgcct
     7741 gaccgacccc gccgcggcgg cggacaggga ccgggcgatg accgcccgcc ccgccggccc
     7801 ggcgcgcccg tccggaccgg cgcgctccgc gagcccgctg ggcgaacacc tggccaaggg
     7861 cttcctcgcc gacggcggac ccccggccgg tgaactcatg ggccaggtcc ggctgaccgg
     7921 ccccgacggc ccgggcccgg ccgactccgt gctcggcccc ggcttcgtac tgctgtgccg
     7981 cgagaacctc gcggacaccc tgtcccccgc cgctctggag accctgcggc tggcatccgg
     8041 ccgggtggtg accgtcctgc gcgcggacgc cggttcggct cccgggccga acacggtgct
     8101 ggacaccgac ggccgctgtc tgccctggct ggactcgata ccggccgggg ccgtcctgat
     8161 ccggcccgac cgctatctgt tcggcgcggc cccggacgcg gacgggctcg ccgtgctgat
     8221 cgcggacttc cggcggcggc tgtgcccggc cacccgaggg ccgggcacag ccgccgggtc
     8281 cgcctgagcg gcccgacggg gctcacaggc tctcagtggt agcggcgtcc ctcgtcacgc
     8341 tggtaggcgt agaacgcgag ggcggccagg ccgacggtcc agaccacgag cgacaccatg
     8401 gcgaccgggt tgatgtcgta gtcgccgacg gtcgcccaca tcagctcggc cgagccccgc
     8461 gtcgggacga acggggcgat cgtctcgatg aatccgggcg cctcgcccgg accgcccagc
     8521 aggcctcccg cgaaggccag cggcaggaag acgagctgga cggtggcgat cgccgccttg
     8581 gtggagagca ggtagccgat cgccagcccc atcatggtga acggcacgga gacgatgatc
     8641 accacgccga tcgccagcag gaagcggacc ggcgagatgg tggcgggggt gaagaaggcc
     8701 gccacgatca cgaccgggaa catcgagaac agcatcatcg cgagaccggt gatgatgcgg
     8761 ctgccgaacc gcaccgccgg gccgatcggc agggtgcggg tgtaggggtc ccagggctgg
     8821 gagcggtctt cggccacacc ggtgccgtgg ccgaagagat tgctgatcat cgccgcgaag
     8881 accaccatcg aggcggtggc gagggtggcc ccggcggggt cgtccttggt gttgggcacc
     8941 acgaagaaga acagcgaggc ggccgggaag aaggccgcgc cgatgatcgc catggggatg
     9001 cggctcagct cgaccagctg gtagcgggca tggacaaggg tcagtgatga catggcctca
     9061 ggcactttcg tgggaggtgc ggtggatcag gactgggaga tcaccaggaa ggcttcttcg
     9121 agcgtggcct gctggacggc gaggccggag aactccacgc cctgacgcac cagtgcccgg
     9181 accagctgat cggcgtcgtg cgtcatcagc tcgacccgct cctccgtccg ttcctcgctg
     9241 atgacgcccg gcaggtccgg cagcggtccg gcgttcatgg acacgcgctg catatgggcc
     9301 atcccccgga tggcgcccac gctgtcgtcc gcccggatgc ggccctgggc gatcaccacc
     9361 acccgcttcg ccagggcctc gatctcctcc aggtagtggg tggtgagcag gaccgtgcca
     9421 ccgccctcgt ggaactcgcg gatgcggtcc cacagcatcc gccgggactc cacgtccagg
     9481 ccggtggtcg gctcgtccag gatgaccagg cgcgggcgtc cgacgaacgc gagggcgagc
     9541 gccagacggc gcttctgtcc gccggagagg ccaccggcct ggcggcgggc ctccttggtc
     9601 aggtcgaacc gctccagcag ctcgtcccgg tcctcggtct ccttgaagtg cgcggccacg
     9661 aagtccaccg cttcggccac ccgcagggtc ggcggaacgc cgctctcctg cggggtgacg
     9721 ccgatgaacc gccggctggc cgggttcgtg ggggcgcctc cgaacagctc gatgcgcccg
     9781 gaggtcggct tgcgcagccc cagcagggag ttgagcagcg tggtcttgcc cgcgccgttc
     9841 ggcccgagca ggccgatgaa ctcgccctcc cgcacggtga agtccacgtt gtccagggcg
     9901 acggtgtccc cgtagtgccg ggtgacgccg atggctcggg cgacgacggc cggggtgggg
     9961 ggagccccgg cgcgtgcggt ggcggtggtg gggctggtgc tcatcggtgc tcctcggttg
    10021 atgggaccgc gctgctctgc gccgggccgg agtggtcggg agggggtgcc ccttcggggg
    10081 ccggccggac ggggaagagc ctcgccagcc gggcataggt ctggtattcc tcgacagtcc
    10141 gcagaccgag gcggttgtgc agcatgtgga cgtgggagac ggtgacctgc gccgggtgga
    10201 gcgaggtctc ccgccgtatg cggtccgaca gtccggtgag cgccgtctgc cacggcgcca
    10261 gcgggcccgg ggtgtctccc ccggtcgctt tggcccgcag ctcgtcggtc ggccgtgcgg
    10321 tccggtacag ctcgtcgagc tgtcgctccg tgtagccgta gccggccgcc cacgtccgcc
    10381 aggcgcgcag tccgtgatcg tagaaggccg cttcttcggc ggggtctgcg ccgagcgccc
    10441 gcgcggcgca gacggtggcg cgcagggcca gcagggcgcg ggccccggtg gagggttcac
    10501 gccggaggaa ggcgaggacc agcctgctgg agagctcgaa gagctgttcg ctcccgggca
    10561 tgagctcacg gccgccgtac cgctcgtact ccgggtggta ggcgaagcgg tggacaccgg
    10621 gctccagcat gccggtgacc tcctggtggg agggctggtc cccggccgtg gtcatggagg
    10681 cggcggtccg cgcgtagtcc gccgggtcca tcgccgtctc gccctcccgc agccgcccgg
    10741 cgtccacgag acgctcggcg aggagccgct ccgccgaagc cgcctggtca tcggtcaagt
    10801 ccccgaggcg caggcggata tggggcccgc cgtgccagta gcgcaggaag aaccacgggc
    10861 ggcccggcag ggtgtgcagc accggtccga ccgtgtcgac caccacccgg tcgtgggcgc
    10921 tccggtcgcc gctcggtacg tgcagatgcc aggtccgcca cacggtgtcg ggtccgccgg
    10981 ggccggcgcc gcccccggcg cgcgcggtct cggatgtgtc cgtcaacttc tgctccctcg
    11041 tcacaggcgt agatcgcaca acagcccctc gaagcgcggg gtcccggtga tggcagcgca
    11101 gacaatcatc tcatcggggt ccaggccgag gagttgtctc gtcgggactt cctggaaggc
    11161 tcgtgcgggc ctcgcgtaca gaccggtggc ggcggcggcc agcgaaatgc cctgggcggc
    11221 ccagcccgcc gcgtactggg cggcggtgaa tccgccgggg cccagccggt ccacgagccg
    11281 tcgtgggtgc gcggagagga accacaccgc gctcgcgtgc cggacgtcgc ccccggcgta
    11341 cggggtgacg gggtagccgt aatgcgtctc cagctcggcc gcggcgccgg gacgggcccg
    11401 gtgcagggtc ggccggccgt ccctcaggtg ccagacgccg tcggcgtgcc cctcgatgcc
    11461 ctggaacacg gcggtcaggc gcagttcctc ccaggcggcg gccaggtgcg ggccgggggg
    11521 cgggacgctc agccagctga cggcctcgcg cagggtccgc tcgggtaccg gccgtctgcg
    11581 gccggtcatg ccgtacatgc cgcgcggcat ccgtcccgcg ctgcggcgcc acagcacctc
    11641 cgcccaggac agcgccccgt cccggggcag accggccggg acggacgggc cgagcggggc
    11701 ggccgaaccc gtgaagtcct gggcgcggtt gacggtcagg atcccgtcga ggaccgggtc
    11761 ggcagcccgc tcagccgggg ctgcggcgac gggcggcccg ccgtcctcca gggccaccgt
    11821 cagcggcagg gaccattccg actcgggcgt caggccgaag tccgtcagca ggcccgccgc
    11881 gttccggtcc ggcagccgca actttccgga caggccgaac agttccattc ccagacacaa
    11941 ctggcgcagg ttgacgccca gttcgaggcc gatcagggag ctgcggaacc accggtaggt
    12001 gtcgggcagc cgggtgtacc tcccggccag cgccacctcc agcggaccgg ccgccccgtc
    12061 ctggcgtccc acgccggtca gcgcgtgccg gtagaggtcg agcacccggc gctggcggcc
    12121 gtcccggacg agcacctgga cgggaaactt cgcccgcacc gagggatagg ggcggtggtc
    12181 gttgaacggg ttctccggct cccgccgttg cagcccgaag cccgctacca gtgcgtgccc
    12241 gagggcgtcg gccctcgcgc gcggggcgtc ggcccggccg tgcggatagg gcgcccgctc
    12301 cagcagttcg gtcgtgcccc ggggcagggg cgtccggtcg ccgagcgccg cctccgggag
    12361 cgccggcgcg acctcggtgt ccgggcgggg ctcggggacg gcctccgcct ccacccgcac
    12421 accgagaccc gtcgcgtagg tgaaccaccg catgtcgcgc gacatgacat cggcatcgtc
    12481 cgggatcggt gacccagggc cgccccggtc gctggtatct gtcatgggga actccgtctg
    12541 cctcggtggt tcggtgaaca tcggcgcgaa tccgccgctc ctgctggacc tgtgggacgt
    12601 ccggggatca ggggaaggcg tgcgggtcgt agggcggcga cagctcgccg gagggggtcc
    12661 cggccagggc cgcctccaac ctcggcagcc cggccacccg ttgctgggcc tggccgaagc
    12721 acatggggac gatgcccggc accacggcct tggcggcggc caggccgatg tcggcgtggt
    12781 cccgtgtggt ggagtccacc aggacgatcc ggtccagtcc ggccgaggcg tacctccccc
    12841 ggatgtagtc cagcgccccg cgcacatcgc ccccggcgac ctgttccagc cggtccggcc
    12901 agcccgcgaa cgcctccgac aggctcatcc ccggcccgcc cagcacggac gtgaccctct
    12961 ccttcatctc gggcagcgcg tagagccgca gatggtcgtc catctcgtcg accagccagg
    13021 ggtcggccag catcggctcg gcctcggaac ggtcccagtc catgcgctcg gtcgccatct
    13081 ggaccacctc ccacagcgcc cctcggaccg cggagaccgg gtcgatgccg gagcccgcgg
    13141 cggagaacgt cgccgggaac ggagcacgtg tgttgaccgc catcgcccag accaccggga
    13201 ggtcgatgtc ctgggtggcg cggagcagat ggatccggaa gccgcgcgag gcggcggtcg
    13261 ccagcagccc ccggacgacc ggatcggtga tcgaggagtg ggtgatctcc ggcagcggaa
    13321 gggcccggtg gaagctgatc aggaaggcgt cccgctcggc gagttccagc agggagtaca
    13381 gcgcggcctc ctccaggcag gagccgaccg cacagccgct ggaggactcc tggtacagat
    13441 gccggcgcgg cgcggcaccg tgccgccgtg ccgcccgctg gtcccgtccg tagcggtagt
    13501 cgtactggaa gaaggcgagt tcggcgggga cgagccgggg ccggccgtcc gccaggtcgt
    13561 gcccccacgc ccagtccatc ggcgtttcgt ccgtcacccg ctcgatccgc gcggtgggac
    13621 gcgccgcctg ctcctcggtg tactcgccga acgcggcggg ccgcaccgcc acctccgctc
    13681 cgccctcggc gctgacgagt tcggcgtacg agaccccctc gacgagcggc gcctggtgcg
    13741 gaaagcccga aagccgctcg tacacctcca ggatggcgat cgggtccgcc ttggcgaagg
    13801 tcgtctcgcg ggcgtagccg agggccaccg cgtcgggctg gagcgccatg ctcatggcga
    13861 agggggccag cagctcccgt tgctgcgcga ggaccggtcc gaagcgcgga tccaccagtc
    13921 gtgagcgcag cgctccgggc cgcaccagtc cggccccggc cgcggcccgg cccggattgt
    13981 ccgcggcggc ggggcgggac ttcagggcca agggctgcgg cggcctcccc accggtcgtt
    14041 cggggatctc cggcgcgcag agcggacagg cgaagtggcg gggtatgcgg tgcgtccgcg
    14101 tcccccgcga ccccaccgcg tacaactcgc ccggccccag ggggcggaca gccagccgcg
    14161 ccagcgccgc gcgggtgagc tcgggaagga acggacggcg tggggcgacc cgcgaggtgg
    14221 gccgggtcag gtcgtcggtc agggggtggt cgatcaccag ccgggagcgc agctcggcgc
    14281 agcccgcgca gccggagtcc gtcccgggca cccagcgggg gccgaccagc acctcgtcgc
    14341 cgtagacgcg gacggacaga tgctcacgcc cgtcggcgga ccgcagctgc tcgcgttccc
    14401 agtccaggtc ccagccgaga ttggcgccga cggtgccgtc cccggaggcg cccagcggct
    14461 ccagcacggc acgccagtcg gtgccctctg cgtcggacag ggcgggtgcg caggccacgg
    14521 tggtcgggtt ctcagccatg ggcggtctcc tcggcgctct cctccgccgc gtgcggctct
    14581 ccgtcgagcg ggacggcccg gacgccgccc gaccacagcg gcaacgcgcc ggtcaccggg
    14641 tccggtcgcc gcggggtgcc ctcgtagcgg agcccggcgg cggccgccgc gtccgcgatc
    14701 tgcttgcgca gcgcggcctg cgccgaggcg tcggcgaaca gcagggcgtc ggtgtgtacg
    14761 ccttcggcca gggggcccgc gccgggcacc ccgtgggcct ggtgccgggc cagcgcggtg
    14821 gccagcgcac ggtgcaccgc ctccgtctcg tcacggcccc agctccgtcc ggtccacggc
    14881 tgcggcccgc cggaggtccg tacctccgcc agcgtccagt ccaggccggg gtggcgcagc
    14941 aaggtcaaca ccgggtccgg catgccttct tcctccagca tgcgcagcag cggcgccgag
    15001 cgcgcctcca cggcccccac ggccctggtc gcgtacggca cggcttcact ggccatcagc
    15061 cgcagcgcac cgtccagcag ccagtgctcc tcggtgagac ccgcggcggc tgcgcccggg
    15121 gtcgggcagg cggcgcggag cgcggcgagg gcgaccgcga ccgtcgccgt ccgctgctcc
    15181 tcggcccagg cgaccacgga gccggcgccg ccgtcgcggt cggccgtctc ccgcagggcc
    15241 agcggcatct ggggcagttc ctcgccgccc agcagcgcga agggtccggt ccaccgcccg
    15301 gtgagcgcgg tcaccgcctc gacggcctcg tcgggggtgg gcggcggtac gggttcggcg
    15361 ccggccaccg gcgcggctgt caggaagcgc cgctcggcgg cttcaccgga agcggtgccg
    15421 ggggccgcga ggctcacacg gtccgccgtc agttcctcac cgtggaggac atgcgcttcg
    15481 ccgggcggcg cgatgcccgc gagggtgtcg aacagcagct gccccgcgag cgccccggcc
    15541 agtgccgcgg ccgtggggtg aggggcgggt gcggtcgctt cgtccacggc ccagcgtgcg
    15601 gcccggcgga cgagcgcggc cgagcccggg agcgacacag caccgggggc ggcgggcccg
    15661 acggcggcga cgagaccgtc ccagcgcacc gggaccagcg gcgccccctc gggcagcagg
    15721 gcggtcagag cttccggggt cacgccgtcg tccgcgccgg ggcagtagag ggcggcgtcc
    15781 ggcggcacgg gcaggtcccc ggggtccgga agcgacgcgg agtcgctgag cggcagcagc
    15841 cgcatgccca gccgggaggt ggtggcagcg gcggcgtcga agtccggggt ggccagcgtg
    15901 agaccggtga tcccggcccg gtgcagtccc cgggcggccg gcagcacggc atcggccgga
    15961 ccgcacagca gcacctcggt ggtgcgcagc cgctggaaga cggcgtacgg gtcggcgcac
    16021 tccgtctcca ggtgtgccag ggcctccggg taacgggccc ggatctcggc cgacggctcg
    16081 ggcacggtca gcgcgcccag gtcgagcagg agatcgcggg cccgcagctc gtcgacgatc
    16141 cggcggacga cgggtcgggc ccgttcactg cccagcgcgg tgaccagctc gtcctcggtg
    16201 gttcccgctt ccagcagcgg cacacaggtg tcggcgaccc ggtagagcag ttgggggccg
    16261 ctgatcacga actgggtgcg ggggccgttg aagtagaccc cctccgagac cggcgcatag
    16321 tgcagatggg ggcgcgcgcg tagcgtcatc gggtctttcc tccgtactgg aaggggccgt
    16381 cgggagcgcg gccgatgtcg acgatccact ccagggcgtg cgggctgtcc gccacccggg
    16441 gaagcgcctc ctccacatag gccgcgtcgc cccgttcccg catccggggc agcacgcgca
    16501 cgctgagggc gctgcccaga tcgacgtact ggggcttctt cttcctgccc tcaccggcgg
    16561 cttggcccgc gccggtggcc tggccctcgc cggagccgtc accgggcggc ggcttcagga
    16621 caacctcctc gggcacgccg tgccggttcc gccaccgggc gagcgccagc agccggtcgt
    16681 gctcggcggg ccccgcggcc accgcctcgt ccagctcccg gcccccgtac cagcggcggc
    16741 gggccagcat ggccgagccg acctggaagc gcgggcaggc ccgggtgcgg tcgccgtccc
    16801 actgccgctc ggcgtgccgg atcgccacga agggttcgcg cagcacgccg ccggagtaga
    16861 gccagttggc cagccggagc ggtgccggga gcctctccgg gtgccccgtg ccgagcgaga
    16921 gcatgtgcag cgggcggccg tcggggtcca cgatgccgag cgcgtccgtg tccgggtcgt
    16981 ggcgcagccg cagccggaac cagtcgtcgg gccccagccg gtccgggagc accggcgggt
    17041 gcgcgttgac gttgagccgg tgcaggcccg ggtcctcgac cagccgcccg tcctgctcgg
    17101 cgtagcgggc gcggagctgc tcgcggaagt ggggcagggc gcgcccgccg agggcgcggt
    17161 ccggtccgag gaacctgccg tagagcatgc cgtggcccgc gtaggcctcg ttgaacagca
    17221 gctgtcgccg ccatgtctgg gtcagcacgc cgtagcggag gtcgccggtc cggaagcggt
    17281 cgggcaggcc cgtggtcagg tcgagtgcct gggaggcgct ccagctgacg gcctcgtcgg
    17341 cggccaccgc ccggtcgatg ccggcgatcg cggtgtcgac gatgttcgcc cggagggcgt
    17401 acagccggtc caaggagcgg tcggccgggc ccagttcgcc ggggggctcg ttctcgggga
    17461 ggcggtaggc gcgccggtag gtctcggcgc tcaggtagtc cgcgtggtcg ctgagcggga
    17521 cctcggcgcc gacgccgaac cgctcgacga agacggcgga cagcaacgcc cgtatgtcgt
    17581 gcatccagtc gaagacggac agcagggcca ctccggcggc gaggtcgtcg agctggctcc
    17641 gccagtcggc ggtggacacc cggacgtcct ccagcaccgc gtcctcctcg atgaggatct
    17701 gcgccggccg tcccgcctcg cggctcagcg tgaccagcgt gtcgcgcagc cggctcagcg
    17761 cctcgggccg ttcgtcggcg gagttgtcgg cgagcccgcg cagttcggcg ccggtctgct
    17821 ccagcagcct ccgggccgtc tccgggaccg tcagaccggc ggggtcgagc agatccggga
    17881 agtcggccgc gccgtcctcc gggcggctgc gggtgcacag gatgccggcg cccaccgcac
    17941 gcgccagggc ctgccgggcg agttcggggg tacagccgga gcgtgcggcg aagtccgcgg
    18001 cgacgtcggc cgcgcggcgt gggccgacgg cgacggcggc caccaacagc ccgaccgcgc
    18061 ccgtgacctt ggccgacagg cggcgcaccc ctccgtcggc tccgggctgc aggaagtaca
    18121 ggaggtcgcc ttcggccgac agctcggatg tgggcggcag ttggagcagg gtgtcggggg
    18181 tgaggtcgcc gcccgaggtg tgcagcccgc ccagtacgta gtcgagcatg acgcggtcca
    18241 gcccctggaa gggcaccacc cgcccgaact ccggggcgtc cgggcccggt ccgtccggtc
    18301 cggggacggc aaggccgatg gcggtgaagc gggccatcgg actggtgcgg atcatggccc
    18361 gggtgacgta ctggaccagc ccgcgctcgg acttgcgcag ccgggtggga acgggctcgg
    18421 tggcggcgac ggccgccctg taccgtccgg cgccggccgc cgcctccggt gccaccagcg
    18481 tcatcgagtg ccgcaggctc tcgtcgccca gcagcccggc cagcgtcccg cgctcggcgt
    18541 ccaccgcccg cgggtagtgg ccgaccacgt cggcggcgag tgcctcccgc cgctgccggg
    18601 cctcccacca gcgggcgacc agggggtggt cgacgagcag cgccggccgt ggggcggtgt
    18661 cgttgtggat ggcgcggcgc agcacgatga gcggcccgcg cgcctcccgg tcggtggtgg
    18721 cgccgatcat ttcgtagagc gcttcggagc accgctcggc cagttcgcgc acctcggtcg
    18781 tggccacgtc cagcgtgcgg agcgctgcca gcagcccggg gtccgcgagc cttctgcggc
    18841 gcagcgggtt gaggcgcagc atccacaggg gctccgcggt gtcgctcatt ccgccgcccc
    18901 ggcggtggcc tgcgccatct cctgtcgcgt ctgctccagc ctgtcctgcc aggaggagcc
    18961 gaggacgtcg tccaccagtt cggcgacggc gaagcagaag tagtagcggt gcatgggcgg
    19021 tacgcccagc agcggcaact gctggtagaa gaggttgacg agcagccggt aggaggcgaa
    19081 ccactgcggc ggcgaggcga tgacgccgga ctcctccatc gtgcggtgga aggcgctggg
    19141 ttcggtgctc acacggccgt ccccgccggg cggccccatg gtggccaggt cgaacccggc
    19201 accgaggccg tcgacgtcgt ccagggtcag ccttccctgg gcgaccgtgg cgtcgaaggc
    19261 ccccatggaa taggcgaagg cacgggccca ggccgacgtc ccgtggtcgg gcgtgccgga
    19321 gagcgcccgc tccacgacgg gccgcaggcg gggggcgtcg gcggccagac gctgggcgaa
    19381 ggcggggcgg gggtccttgc gggcggccgc ccaggcgaag aacgcctcgg cgtgcgaacg
    19441 catcgagaac gccccgttcc cggctccgtg ctggtgcgcc gcggccagcg cggcgaacgc
    19501 ctccatgatg cgtacgggcg cctcgcgcgg ctccccggcc aactgctcga ccgtggtggt
    19561 cagcggccgg tccagttggt ccagggccag ttcccgcagg tcctggagcg gctgcggcca
    19621 ggtctcgacc gacgagaggc tcagcgcctc cgtggcaccg tgctcacgca tcggcaggta
    19681 gggcggtgcg atgccttcca gccggcccat ctcacgggcc tgggcgagat aggtctcctc
    19741 gtccgtcacg gccgggccct cggcggggcc ggcgtcgagg gcggcggcga tccccgccca
    19801 gtcgagcgcc ggacgcccgg gcacgctccg ggcgacgatg tcgatgtgcg gaccgtaccg
    19861 ccagccccgt cgcaggtgga ggagggcggc ccggtggtcc tcgcggaggc ggcggctgac
    19921 cggcagcacg gtcttcgcca gccatcgagg ggtgatgggc acccgggagt acagccgtac
    19981 gcccgccgcc tcggacatgt ccggaccggc ggctgctgtg tctgtgatca cgctgcgtac
    20041 ccgttcatga tcggaaggcg tttcgggaga tggcggccgt ctgacgtggt gtgacgcagc
    20101 ccggcagagc tcacaatgcc gccgcgccgg gccgcggaca acgagcagtg gacggaacct
    20161 gacatctgtc atgtgccgcc ggaccgtccg ccgtggcgcg gtccgcggac ggtggacggc
    20221 cgaaggcccg cagaagcggc cgtaccgggc ggctccggcg ccctccggac cgggtcgccg
    20281 ggatgataga accttggctc ccgcggacag ttcgccgagg tctccacgca atggacggag
    20341 catcaggatg gttacgcagc agcgcccttc gacggtgtac agcacggagc acgccgagat
    20401 ctacgatttc atccacgcgg cccggggccg ggactggtcg gccgaggcgg acggcatcac
    20461 ccggctgatc cgggagcgtt gtcccgaagc gggttcactg ctcgatgtcg cgtgcggcac
    20521 cggtgcgcat ctggagcggt tcgccgaaca cttcggcacc gtggccggcg tcgaactctc
    20581 ccccgagatg cggaggacgg ccacgaggag ggtcccggcg gcccgcgtgc acgaggggga
    20641 catgcgggag ttcgagctcg gccggacctt tgacgcggtg ctctgcatgt gcttctccct
    20701 ggggtacatg agcaccgtcg aggaactgcg tcgcagcgcg gcgaccctgg tgcggcatct
    20761 ggtgccgggc ggagtcctcg tcgccgaacc ctggtggttt cctgagcagt tcatcgacgg
    20821 gttcatatcg gcctccctcg cccaggagga gggccgcgcc gtcagccggc tgtcgcactc
    20881 ggtccgggac ggacgcatca gccggatgac ggtgcgctat accgtcgcgg aaacaaccgg
    20941 tatccgtgaa ttcaccgaat acgaaacgta ctcactgttc acccaggagg aatacctgga
    21001 cgccttccgg caggcggggt gcgagatgga gttcctctcc gactggccga acggcagggg
    21061 gctgttcatc ggggtccgcg catgagggaa accacccacg gaaccgcccc ggcacagtga
    21121 cgaggaagcg gggaaacccc atcccccgcg tcgccctgac agatccgcgc cgcgacagca
    21181 aggcgcggag gcaggttcct gatatgtgtc acagcccccc tcacttcgat cccgcgggcc
    21241 gcaggggtgg gctagctttc cgcggagaat gccgacggcc cctcccgggg ccctcggtgg
    21301 atcgaccgca cattccgggg ggagaccatg agcgagccgt cggaccggat cgccggagtc
    21361 ggcgcgcgtg ccgacagcgg cgtggaggtc ttcgagcgtc actacgccgg cgagccgggc
    21421 gccggctggg agatccagcg gccgcagacg gtcctcgtac gcctcgccga ggagggcgcg
    21481 ctccgcggcc gggtgctcga cgtcggctgc ggcagcggcg acaacgccct gctggccgcc
    21541 gaacacggcc tggagacgac gggggtggac gccgcgccca gcgcgatctc cctcgccgtc
    21601 ggcaaagcgc gggaacgcgg cctgaaggcg cgcttcctgg agtgggacgc cctggacctg
    21661 gcggcgctcg gcgagcagtt cgacacgctc atcgacgtcg ggctcttcca ctgcttcgct
    21721 cccgaggacc ggcccctcgt cgcccgcagc atggcctccg tcgtaccgcc cggcggacgc
    21781 tgtttcctga tgtgcttcag cgaccggcag ccgggcacct ggggtccgcg acgcgttccc
    21841 gagcaggccg tccgggagag tttcaccggc gccgggtggc gcgtggacac gctcgaagca
    21901 gccgaactcg acgtcgcctt cagccccggg gtcgcccagg cctggttcgc tgccatgacc
    21961 cgcctctgag cgggtcggag agaagacgac catgcgcgtc ctgttctgca cctggcccgc
    22021 cgcggcccac ctctacccca gtgtgccgat ggcccgggcc ctgcacgacg cgggccacga
    22081 ggtgcgggtc atctcccacc cgtcgctgct ggacacgatc aacgcgacgg ggctgacggg
    22141 ggtgtcgctc ggcgacgagc agaccctgcc gcagccgctg ggcgccggcc gccccctctc
    22201 cccggacacg tacgccgacc tcgtccgcat caccaagtcc ctcgaactgg acggctacga
    22261 gcggtacgtg tggacctact accgggacta catgctgccg gcggtccgcg acttccagcc
    22321 ggagggcgct cccgccggcg aaccccagaa cgccctcgac gcgctggtcg gcttctgccg
    22381 ttcctggcgg cccgatctgg tcctgtggga cccgacgatg ccggccgccg gtgtggccgc
    22441 ccgggtgtcc ggcgcggccc acgcccgcat cctgtgggga ccggacctgt tcggctgggc
    22501 gcacgagcag tacacccggt gcaggaagct ctccggtgac gccctcctgc ccgaggatcc
    22561 gatgacctcg tcggtcaggc cgatggccga gcgctacggg ctccccatga ccgacgagct
    22621 gctgttcgga cagtggacgg tcaacccggt gctggagcgg atgcgcctgc ccaccgtgaa
    22681 gcgcaccgtg tcgatgcgct ggcaggccta caccggcccg gcggtgctgc ccgactggct
    22741 gagggaacca cccgcacggc cgagggtggc catcaccctc ggttcctcga tacgggcctg
    22801 ggggcgggac agcgccctgc tcgtcaaccg cgtactggag atggtggacg gcctggacgt
    22861 cgaggccgtc gccacgctgg acgcctccca gctcgcggtg gccgaccgga tacccgacaa
    22921 cgtccggacc gtcgactacg tcccgctgac cgaactgctg ccgacctgtt cggcggtgat
    22981 ccaccacggc ggccacggct cgttcggcgc cgccctggtc aaccggatcc cgcagttcgt
    23041 cgtgatggac cccggctacc ccatggaggc gccgatcacg ggccggttcc tctccgagag
    23101 cggcgtggga acgggggtgc gcgtcgaccg gcacaccggc gccgaactgc gtgcggggct
    23161 gtcccgcctg ctcaccgcgc cgtccttccg cgacgccgcg gcggagctgt acacggacct
    23221 gctgaccgct ccggagccga gcgagatcat ccccgtcctg gagcgcctca cccggcacca
    23281 ccagagccgg gactgaaccc gcccccttcc catcgtcccc accgcgccag ggagccaccg
    23341 cgtgatcaac gtcttccagc cgagcctggg cgaggcggaa ctcctcgccc tgtccgaggt
    23401 cttcgcttcg aactggctgg gccacggacc ccgcaccgac gagttcgaag cacgcttcgc
    23461 ggaccacatc ggggtcgagc cggaccggat ggtcttcctc aactccggta cggccgggct
    23521 cttcctcgcc accgagctgc tcgatctggg ccccggcgac gaggtggtac tcccgtccgt
    23581 gagcttcgtg gccgctgcca acgccatcgc cgcgaccggc gcgcgccccg tcttctgcga
    23641 cgtcgacccc catggtctcc acccgaccgt ggagcacgtc gagcgtgcca tgacgccccg
    23701 taccagggcc gtcatcgtgc tgcactacgg cggctacccc ggggaggtcg cggggatcgc
    23761 ggccctgtgc cggcagcggg gggtccccct cgtcgaggac gcggcctgcg cggtggcctc
    23821 cacgatcgac ggcagggcgt gcggcacctt cggcgacatc gccctctgga gcttcgacgc
    23881 gatgaaggtg ctggtgaccg gtgacggcgg catgctgtac gtccgcgatc cgcagctcgc
    23941 acgccgcgcc cgggtgctcg cctaccacgg tctggagcag cccagcggct tcgcccacgc
    24001 gaaggtgtcc gagcggtggt gggagctcga cgtacggagc ttcggccgcc gcgtcatcgg
    24061 caacgacctg accgccgcgc tcggcacggt gcagctcggc cgactgcccg ccaacgtcgc
    24121 ccggcggcgc gaggtggcga ccgcctacga caccctgctc gcgaacaccc ccggcgtacg
    24181 cctgccgccc ccgctgcccg aggggcaccg ctcctcgtac tacttctact gggtccagat
    24241 ggatccgctc atccgtgacc gggtcgcggc cacgctgctg gcccaggaca tctacaccac
    24301 cttcaagtac ccgccgctgc accgggtgcc cgcctacggc gaccgggcca ccgacctgcc
    24361 cgggaccgac ctggccaccg acagcacact cctgctcccc ctccaccagg cgctgagcga
    24421 cgcggacatc cggacggtgg cgaacgcgct gtgcgaagcc gtcacccacc acctggccct
    24481 ggccggggcc tgacgcacgc cgacgggaat caccgaggga ggcgcccgcc tgtgggcatc
    24541 gacgagacag ccgttccagg tgcgtacgcg cacgcgcccg gccgggcagc acgccccccg
    24601 cgcgccccgg cccgcaccgc tccacgggag gaacgcccat gaaggcgctg atactcgccg
    24661 gagggctcgg gacgcggctg cggccgttca ccgagaccat gcccaaacag ctgatcccca
    24721 tcgccaacca gcccgtactc gaacacgtgc tggagaacct ccgcgcgctg ggcgtgcggg
    24781 agatctgtgt ggtcgtcggc gcgtggggac ccgacatcgc ggcacggatc ggcgacggat
    24841 cgcggttcgg cgcccggatc acctacctca cgcagcagcg gccgctgggg ctggcgcact
    24901 gcgtggccat cgcccgtccg ttcctcggcg acgacgactt cgtgatgtac ctcggcgaca
    24961 acgtcgtgca ggacggcata gcggggccgg ccgaggagtt ccgggcccgc cggtccgacg
    25021 cgcacatggt ggtggccagg gtcgccgacc cccgcgcctt cggggtggcc gagctggacg
    25081 ccctcggccg ggtccgacgg ctggtggaga agccgcgcct gccgctcagc gacctggcgc
    25141 tcatcggcgt ctacttcttc cgccccgcca tccaccgggc ggtcgccgcg atcggcccga
    25201 gcgcacgcgg cgagctggag atcaccgacg ccgtccagtg gctggtcgac cggggaggct
    25261 cggtcacggc gggtgaatac accggctact ggaaggacac cggacgtgtg gaggacgtgc
    25321 tggactgcaa ccggcgtctg ctggacagcc tggcccgggg cgtccacgga acggtcgact
    25381 ccgccagccg cctgaccggc ccggtgcaca tcgccccggg cgccaccgtg ctgcgctccg
    25441 tcatcaccgg gccggtgatc gtcggccccg ggtcccgcgt cgaggactgc cgtatcggac
    25501 cgggcacatc gatcggcggc gactgcgtcc tgcgcggcac cgagctggag aactccatcg
    25561 tgatggacgg cgcgtgggtg acggaacgga ccggtgcgag cgacctgctc atcggccgct
    25621 cgatgcggat cggctccgac tcgccctcgg tgccaccgcc cccggaactg gctgcgaacg
    25681 gcgcgcgtac aggaggaacc cgatgaggat tctggtcacc ggcggggccg ggttcgtcgg
    25741 ctcgcactac gtccgcacga tgctggcgca ggggtacccg ggctacgagc gggccgacgt
    25801 caccgtgctg gacaagctga gctacgcggg caacgccgag aacattccga tcggccaccc
    25861 ccggctgcgt ctcgtcaagg gcgacatctg cgacgcgccg ctgctgaacg aactgctgcc
    25921 cggccatgac gccgtggtgc acttcgcggc cgagtcgcac gtcgacaggt ccctggacgc
    25981 ccccgccgtc ttcacccgga cgaacgtggt gggcacccag accctcctgg acgcctgcct
    26041 gaacgccggg gtggagcggg tggtgcacat ctccacggac gaggtgtacg gcagcatcgg
    26101 cgagggctcc tggcacgagg agtcgccgct gctgcccaac tccccctacg cggcctccaa
    26161 ggcggcggcg gacctgaccg tacgcgccta ctggcggacc ttcgggctcg atgtgtcgat
    26221 cacgcgctgc tccaacacgt acggcccgta ccagcacccg gagaaggcca tcccgcggtt
    26281 caccaccaac ctcctggagg gcgagccgat cccgctgtac ggctcagggc ggaacgtgcg
    26341 cgactggatc catgtggacg accacgcgcg ggccgtccag ctcgtgctga ccaagggaat
    26401 cgcgggcggc atctaccacg tgggcggcgg ccacgagctg accaacatcg agctggcgga
    26461 gcagctgctc gccctgtgcg gcgcggaccg gtccatgatc cggcatgtga ccgaccgcaa
    26521 ggggcacgac ctgcgctact cgctggacgg gtccaaggcc cgtaccgagc tggggttcac
    26581 gccacgggtc ggcttcggcg aaggactggc cgccaccgtc gactggtacc gggagaacac
    26641 ggcgtggtgg aaggccgcga agggccaggc agcggacacg gaggaccggt cgtgaacgac
    26701 gagcacagga cacgggtcct ggaagaggcg cggaagcacc accagagtgt gcgtgattcc
    26761 ggggagttcg tgccgggcac cacggagatc tggccgtccg gcgccgtcct ggacgaggac
    26821 gaccgcgcgg cgctggtgga ggccgccctg gatctgcgga tcgccgccgg gccgctctcc
    26881 aagcgcttcg agtcggagtt cgcgcggctc ctgaagcgtc gcaaggccca tctgacgaac
    26941 tccggttcgt cggccaatct gctggcgctc accgcctaca cctccccgca gctgggcgaa
    27001 cggcggctgc tgccgggcga cgaggtcatc acggtcgccg cggggtttcc caccacggtg
    27061 aacccgatcc tgcagaacgg gctggtgccg gtcttcgtcg acatcgagct cggcacgtac
    27121 aacaccaccg ccgaccgcgt cgccgcggcc atcgggccca agacccgggg catcatgatc
    27181 gcgcacgccc tcggcaaccc gttcgaggtc gaggagatcg cccaactcgc cgcggaccac
    27241 ggcctggtgt tcgtcgagga caactgcgac gcggtcggca ccacctaccg ggggcggctg
    27301 accgggacgt tcggcgacat cagcaccgtg agcttctatc ccgcgcacca tctgacgatg
    27361 ggcgagggcg gcatcgtgac gacctcggac ctcaaggtcg cgcggatcgt cgaatcactg
    27421 cgggactggg ggcgggactg ctggtgcgaa ccgggccaca gcgacacctg cctgaagcgc
    27481 ttcgaccacc agctcggcgc gttgcccgcc ggctacgacc acaagtacat cttctcccac
    27541 gtgggctaca acctgaagtc gacggacctg caggcggcgc tcggcctgtc acagctgcgg
    27601 aagctggacg ggttcatcgc ggcgcgtcgc cacaactggc ggcggatgcg tgagggcctg
    27661 gacggcgtac gccatctcct gctgccggag gcgactgccg gcagcgaccc gagctggttc
    27721 ggattcgtga tgacggtggg gcccgacgcc ccgttcacgt gcggagagct gaccgggtac
    27781 ctggagaagc ggaagatcgg tacgcgccgc ctgttcgcgg gcaacctcac ccgtcagccc
    27841 gcctatcacc agcagcccca ccgcgtcgtc ggcgaactga ccaacagcga catcgtcacg
    27901 gagcgcacgt tctggaccgg ggtctacccg ggcctcaccg acgagatgac cgactacgtc
    27961 atcgcctcgg tacgggagtt cgtggcaggc cgtcggtgag agtcgacagc tcccggccgc
    28021 acggcacgga ggccggaccg ggcggaccgg gcggactgag cgggctgagc gggctgagcg
    28081 aggaggccgg gcaggacggg cagcgcgggc tggcggccag gatcgcccgc tccgtggccg
    28141 ccaccggtcc ggccaccgga gcccggacca cgacgggcga gatcgccgcg tggctggcgg
    28201 aacgccgcag ggcccacggc acacggatcc ggcgcatccc gttcgcggag ctggacggct
    28261 ggtcgttcca ggaggacacc gggaacctgg tccaccgcag cgggcgcttc ttcaccgtcg
    28321 agggcctgcg cgtgcacgac gcggaccggc ccggcgctcc gcgggagcag cctgtcatga
    28381 ggcagccgga ggtcggcgta ctcggcctgc tcgccaagga gttcgacgga gtactccact
    28441 tcctggccca ggccaagatg gaaccgggca accggggcat gctccagctg tcaccgaccg
    28501 tgcaggcgac ccgcagcaac taccagcggg tgcacggcgg ttcgggcgta cggtttctgg
    28561 agttctttac cgagcccggc cgcgcccggc cactgaccga cacactgcag tccgagcacg
    28621 gcgagtggtt cctgcacaag tcgaaccgca acgtcgtggt ggagacggcc gacgaggtcg
    28681 ccgaggaccc ggccgccgaa ccggacttcc gctggctgac cctgggccag gtcggcgagc
    28741 tcctgcggct ggacaacgtg gtcaacatgg acaccaggac cgtgctggcc tgcctgccga
    28801 cccctggagg gcaagggccg tcccggcaca ccgacgccga ggtgtcgtcc tggctcggtg
    28861 ccgcccgctc ccgctcccgg ctcacggcc
//
