LOCUS       NZ_LFBV01000013        21518 bp    DNA     linear   CON 03-MAY-2024
DEFINITION  Streptomyces uncialis strain DCA2648 scaffold13, whole genome
            shotgun sequence.
ACCESSION   NZ_LFBV01000013
VERSION     NZ_LFBV01000013.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces uncialis
  ORGANISM  Streptomyces uncialis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 155014)
  AUTHORS   Yan,X., Huang,T., Ge,H. and Shen,B.
  TITLE     Cloning and characterization of the uncialamcin biosynthetic gene
            cluster
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 155014)
  AUTHORS   Yan,X., Huang,T., Ge,H. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-JUN-2015) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33410, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 19-MAY-2015
            Assembly Method                   :: CLC Genomics Workbench v. 8.0.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905345.1-RS_2024_05_03
            Annotation Date                   :: 05/03/2024 03:03:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,456
            CDSs (total)                      :: 7,371
            Genes (coding)                    :: 7,214
            CDSs (with protein)               :: 7,214
            Genes (RNA)                       :: 85
            rRNAs                             :: 6, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1 (5S, 16S)
            partial rRNAs                     :: 5 (23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 157
            CDSs (without protein)            :: 157
            Pseudo Genes (ambiguous residues) :: 0 of 157
            Pseudo Genes (frameshifted)       :: 42 of 157
            Pseudo Genes (incomplete)         :: 143 of 157
            Pseudo Genes (internal stop)      :: 7 of 157
            Pseudo Genes (multiple problems)  :: 33 of 157
            CRISPR Arrays                     :: 14
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:56:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 12495
            Orig. end                         :: 34013
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LFBV01000013.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21518
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="CDPS"
                     /region_number="1"
                     /rules="CDPS"
                     /tool="antismash"
     cand_cluster    1..21518
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="CDPS"
                     /kind="single"
                     /product="CDPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21518
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="False"
                     /core_location="[10000:11518](+)"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11518
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
     misc_feature    complement(126..139)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            367..1122
                     /locus_tag="AB852_RS36370"
                     /old_locus_tag="AB852_35775"
     CDS             367..1122
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1261: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004979532.1"
                     /locus_tag="AB852_RS36370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_35775"
                     /product="(Fe-S)-binding protein"
                     /protein_id="WP_073795669.1"
                     /transl_table=11
                     /translation="MRVALFLTCVNDTLYPGTGRAVVKLLAGLGVDVDFPLGQTCCGQP
                     QYNTGYRRGTEPIARRLAEVFRDHDAVVTPSGSCAAMVREMYPRLGERARAEGRGDALA
                     TALAPLADKTYELTEFLVDVLGVTDVGAWYPHTVTYHPTCHGLRSLRLGDRPLRLLRAV
                     RGLELVELPGAEECCGFGGTFAVKNPGVSVAMGTDKVRSAEGTGAEVLCAADNSCLLHL
                     GGLLGRQGSRMRPVHIAEILASTREGVRR"
     misc_feature    complement(385..398)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.92"
                     /tool="antismash"
     gene            1119..2621
                     /locus_tag="AB852_RS36375"
                     /old_locus_tag="AB852_35780"
     CDS             1119..2621
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0019516 - lactate oxidation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019521306.1"
                     /locus_tag="AB852_RS36375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_35780"
                     /product="lactate utilization protein B"
                     /protein_id="WP_073795672.1"
                     /transl_table=11
                     /translation="MSATPLGMPAFPDAARDALRDTTLRGNLRHATHTIRDKRARAVAE
                     LSDWARLREAGKQIKDHTLRHLDHYLLRLEESVTAAGGTVHWAADAAEANRIVTELVKA
                     TGEREVVKVKSMATQEIGLNEALAAEGIRAYETDLAELIVQLADDRPSHILVPAIHLNR
                     AEIRDVLASAMGDWGRPAPDGLTDAPAELAEAARLHLREKFLRAKVGVSGANFMVAETG
                     TMVVVESEGNGRMCLTLPETLISVVGIEKVVPAWRDLEVFLQTLPRSSTAERMNPYTSM
                     WTGVTDTDGPSAFHLVLLDNGRTDTLADEVGRQALRCIRCSACLNVCPVYERAGGHAYG
                     SVYPGPIGAILSPQLRGTGSAVDASLPYASSLCGACYDVCPVAIDIPEVLVRLRERVVE
                     GGPAVRRGTRVVLRPARGHAAQRAAMRAAGWVFTRPAALAAGQRLLSRTRRLHPRRLPG
                     PGRAWSADRDLPEVPEESFRDWWRRTSGGRDSAGGSGREERS"
     gene            2618..3310
                     /locus_tag="AB852_RS36380"
                     /old_locus_tag="AB852_35785"
     CDS             2618..3310
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015655908.1"
                     /locus_tag="AB852_RS36380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_35785"
                     /product="LUD domain-containing protein"
                     /protein_id="WP_073795903.1"
                     /transl_table=11
                     /translation="MNGREVVLGRVRRALADGSGASPGPDGPVAYDGVRDYLRVHGERT
                     PEESVDLLAARLTEYRALVHRTDDEGLPELLMRLLSEQGPDEMLVPPALPPYWLSAADP
                     VRVHDRAALTARRLDRVGSVVTGCALAIAETGTIVLDGGPEQGRRRITLIPDHHICVVR
                     VPDQVVCSVPQAIERLDPRRPQTWISGPSATSDIELDRVEGVHGPRTLEVVLLSGDGHA
                     CAGGDGPG"
     gene            3320..4483
                     /locus_tag="AB852_RS36385"
                     /old_locus_tag="AB852_35790"
     CDS             3320..4483
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018385814.1"
                     /locus_tag="AB852_RS36385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_35790"
                     /product="betaine/proline/choline family ABC transporter
                     ATP-binding protein"
                     /protein_id="WP_073795674.1"
                     /transl_table=11
                     /translation="MIRFEQVGKRYPDGTTAVDDLSFEVREGELVTLVGPSGCGKTTTM
                     MMVNRLIEPTSGRILIDGEDISTVDPVKLRRRIGYVIQQVGLFPHRTVLDNTATVPTLM
                     GWKRTRARERAAELLDLVGLDPALFGSRYPEQLSGGQRQRVGVARALAADPPVLLMDEP
                     FGAVDPVVREQLQDEFLRMQDAVRKTVLLVTHDIEEAVRLGDRIAVYGQGRIEQFDTPG
                     AVLGTPATPYVAEFVGADRGLKRLSVTAIEPDDLEQPVVVRTGEPAGRAAGRLRGEDAR
                     WGVVLDTDGDLHGWVGVDELALAGPGATVGDLAHRMNAWVPVGAPLKQAFGVMLQHDAG
                     WVAVIDGARFLGVLTPAKLHEALRRSVDADAQGVARDEVSFDSVSDV"
     gene            complement(4743..5690)
                     /locus_tag="AB852_RS36390"
                     /old_locus_tag="AB852_35795"
     CDS             complement(4743..5690)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006350965.1"
                     /locus_tag="AB852_RS36390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_35795"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_073795676.1"
                     /transl_table=11
                     /translation="MNRRAAPAAVLALLCLTAGGCAGGPSLETRDAVAASPGDNKNLVV
                     GSAGFTESDVLAQMYALLLKHAGYSTRTLTVANRELYEPALESGQIDVVPEYAATFADW
                     LNAKANGPDAPPAGSPDLTTTMDNLRRLATPRGLTVLDPGRAVDQNAFAVAASYAREHR
                     LKTLSDLGRSGLKVRLAAGDECVKRPYCEPGLKKVYGIDITGIDPKGVGTTQAKKAVQS
                     GQDQMVLTTTTDATLAQFGLVILADDKHLQNADYIVPVVNRSRAGGAGPTKALDKLNKV
                     LTTADLASLNQQIDSWRRLPQDVARTYLEDKGLL"
     gene            complement(5687..6364)
                     /locus_tag="AB852_RS36395"
                     /old_locus_tag="AB852_35800"
     CDS             complement(5687..6364)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018533624.1"
                     /locus_tag="AB852_RS36395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_35800"
                     /product="ABC transporter permease"
                     /protein_id="WP_073795678.1"
                     /transl_table=11
                     /translation="MTTLTDAWQWLADPAHWSGDDGVWHRLLQHFLLTVVCLVISCLIA
                     LPVALVLGHLGKGGALAVNISNVGRAVPTFAVLVLLLLTPVGEYGEGPTVIALVLFAVP
                     PLLTNAYVGMRGVDQDVVRAARGMGMTGRQVLLRVELPLASPMVLSGVRIAAVQLVATA
                     TIAALAGGGGLGRIITAGFNLASTPQVVAGAVLVAVFALLVEGVFEAVERLAPNRARAG
                     RGG"
     gene            complement(6390..7067)
                     /locus_tag="AB852_RS36400"
                     /old_locus_tag="AB852_35805"
     CDS             complement(6390..7067)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894158.1"
                     /locus_tag="AB852_RS36400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_35805"
                     /product="ABC transporter permease"
                     /protein_id="WP_073795680.1"
                     /transl_table=11
                     /translation="MTPPDDCLARNDWICGEYLTTRSHILTDATVQHLQLTFLAVLIAL
                     VVAVPLAVAARRWRWASGPVLAVTTVLYTIPSLAMFSLLLPAYGLSASLVVAGLVLYSL
                     TLLVRNILVGLRGVPEETRQAARGLGYGPVRLLLTVELPLALPASMAGLRIATVSAVSL
                     VTVGAIVGFGGLGNLIYAGMNTYFKAQVLTASVLCVVIAVAADLLLLGVQRLLTPWTRA
                     ARA"
     misc_feature    7069..7085
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.03"
                     /tool="antismash"
     gene            7280..8158
                     /locus_tag="AB852_RS36405"
                     /old_locus_tag="AB852_35810"
     CDS             7280..8158
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005308813.1"
                     /locus_tag="AB852_RS36405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_35810"
                     /product="hypothetical protein"
                     /protein_id="WP_245877059.1"
                     /transl_table=11
                     /translation="MPASPTRTFRTRPAVRTVARTSRSTGTARTVRATRSALAALSCGA
                     LLLTGCSAGAGSGRAGGGGPAPLNAKAGSATGPSARPPIEGRPGPGTAGEVAAVPGLGP
                     GTRARIPARTRQALVVTGAGRDSSAGTAALHQQGAQGVWRTVAGPWPAHNALRGWTDDH
                     RAGDLRSPIGVFGLGDAGGLLPDPGTALPYDQDIEFGDSGTGYLDESLEGSFDYVLAID
                     YNRVPGTSPLDKTRPLGADKGSGIWLHVDHGGPTKGCVSLPRGRMRELLRALDPRLRPV
                     VVMGDAASLRG"
     gene            complement(8342..8722)
                     /locus_tag="AB852_RS36410"
                     /old_locus_tag="AB852_35815"
     CDS             complement(8342..8722)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018523311.1"
                     /locus_tag="AB852_RS36410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_35815"
                     /product="VOC family protein"
                     /protein_id="WP_073795683.1"
                     /transl_table=11
                     /translation="MPVPKTAVLALDCADPEALAEFYAALLGGEIRPTGDPDLVEVRGE
                     DGSVLGFQRDHGFAPPSWPRPEDAQQAHLLIMVARSDLDEAEREAVSLGATPMDVQGRG
                     TTREGRLLSDPAGHSFMLRSLK"
     gene            9109..9660
                     /locus_tag="AB852_RS36415"
                     /old_locus_tag="AB852_35820"
     CDS             9109..9660
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00881"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1159: dihydropteridine reductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016572569.1"
                     /locus_tag="AB852_RS36415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_35820"
                     /product="nitroreductase family protein"
                     /protein_id="WP_245877060.1"
                     /sec_met_domain="PF00881 (E-value: 7.8e-15, bitscore: 48.4,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTQQSSAVMRVLRTRSAVRQFTDQPVSDGQLEQLIDAILAAPTG
                     GNKQAWAFVAVRDPRTLRLVRAFSPGMIEPPPLVVVACFDRSRAVKDDGEFWDEGLLCV
                     AMAVQNLLLAAHSLGLGGCPAASFRRGSVATILGLPSHLEPLLLVPLGHPARDLVSPPR
                     RDRSEVVSHEFWGNGTPADR"
     gene            9623..9964
                     /locus_tag="AB852_RS36420"
                     /old_locus_tag="AB852_35825"
     CDS             9623..9964
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016471397.1"
                     /locus_tag="AB852_RS36420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_35825"
                     /product="DUF6092 family protein"
                     /protein_id="WP_073795687.1"
                     /transl_table=11
                     /translation="MSSGETALRPIDEELLLLTAYLLSSGRGLLEEPQQYGPFRCIDAA
                     RRVLVLLRDRGVTNSELQELHGRLEDFMCGPMAPRDLTAFLDEVCGKLTLLLRDSDLIR
                     RGPASPATT"
     gene            10001..11518
                     /locus_tag="AB852_RS41235"
     CDS             10001..11518
                     /GO_function="GO:0016755 - aminoacyltransferase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (279-373). E-value: 7e-12. Score:
                     36.0. Matches aSDomain: nrpspksdomains_AB852_RS41235_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) CDPS:
                     CDPS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR04539.1"
                     /locus_tag="AB852_RS41235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tRNA-dependent cyclodipeptide synthase"
                     /protein_id="WP_073795689.1"
                     /sec_met_domain="CDPS (E-value: 5.1e-67, bitscore: 218.8,
                     seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKFEVEPVTPTCRRIYERGDHALIGVSAGNSYFHQERLGSLLAW
                     AEEHFTLVDVLYIDTHIDAMLIATGLTPAQAGSRTRSMLKDVRRRIRRALEKTSGTAHG
                     RLRVRSMSECAQLPAYQEVLRRLDRDFDDSGPVRRAAEEQVRELLEHHSGPVTEHSADS
                     VQIQAGLAYVRSEIPFLLDTPAILGVPSSVTCYHKLMPVVTALYQEPGSPGRSPRQGFL
                     VVSPEPVAAPDSPPQQTRSRTRREQLTLTEQYDEIAADYTDVERVFSTYRSLIEIPSLL
                     RALGPVEGASVLDLGCGSGAYARLLRRRGAAEVLGVDVSPGMIEVARALEEREPVGVRY
                     EVVDAADMPVLGTFDAVVAVAVLHYADSRATLARMMRQTWANLAPGGRFLAYVGNPRLP
                     ADSAQMNGLVVHRPDNARDGDPSPLTIPTTPPTTLPARYWSCETIEKTLRASGFTDVVW
                     EPLDGLPSGAQEPVNLLVSARAQPVGAAEAVAPSAHERAPLAATAAQ"
     aSDomain        10838..11119
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AB852_RS41235_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="7.00E-12"
                     /label="AB852_RS41235_oMT.1"
                     /locus_tag="AB852_RS41235"
                     /protein_end="373"
                     /protein_start="279"
                     /score="36.0"
                     /tool="antismash"
                     /translation="LLRALGPVEGASVLDLGCGSGAYARLLRRRGAAEVLGVDVSPGMI
                     EVARALEEREPVGVRYEVVDAADMPVLGTFDAVVAVAVLHYADSRATLA"
     gene            complement(11554..12132)
                     /locus_tag="AB852_RS36430"
                     /old_locus_tag="AB852_35840"
     CDS             complement(11554..12132)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012655.4"
                     /locus_tag="AB852_RS36430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_35840"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_073795692.1"
                     /transl_table=11
                     /translation="MARPRKFDEARAVGSAMDAFWRQGYHATSTRDLTDRTGVGPSSLY
                     NTFGDKRQLYLRTLREYFAVHTAEQTRGLRAPGPAKERLRHLMVHAVDLDLSGTGPAGC
                     FAVNALIEMGSEDPDVAEELQRHFGAVEDALTDTVAEGQRDGGITAPGDARTLARQVLS
                     TYYGLRVLARVQKDRQALLAVADSALAAL"
     misc_feature    complement(12253..12262)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.4"
                     /tool="antismash"
     gene            12366..13580
                     /locus_tag="AB852_RS36435"
                     /old_locus_tag="AB852_35845"
     CDS             12366..13580
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) Chlor_Efflux_Pump"
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003982758.1"
                     /locus_tag="AB852_RS36435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_35845"
                     /product="Cmx/CmrA family chloramphenicol efflux MFS
                     transporter"
                     /protein_id="WP_073795694.1"
                     /transl_table=11
                     /translation="MPLAVYVLGLGIFTQGTSEFMLSGLLPGMADDLGVSIPDAGLLIS
                     AFAIGMVVGAPLLAVATLRWPRRTALVALQGVFIAAHVVGALAPGYGPLFATRIVSALA
                     YAGFWGVAVATAVALVPADAKARAVAVVAGGLTLATIVGVPAGTVLSQFAGWRAAFWGV
                     AVLTLVSLVCTVFAVPGGKGAREEPRTVRAELRAMRRPQLWLSYAVTAFAFGAVIVTFS
                     YLAALLTGVSGMSEGWVPVVLALFGVGGLVGMTIGGRQPEERSVPTLVAGLAVLTVASA
                     ALALTARHTAVTLVLVFVLGLAGYVTNPALQARVFTLAPGAPTLVGATNTAAFNIGNTL
                     APALGGATIAAGWGYPSVAWVGAALALLGLAGALWAGALERRDRRTGIPAVPTASRRTA
                     EHADA"
     misc_feature    12372..12374
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(13834..14613)
                     /locus_tag="AB852_RS36440"
                     /old_locus_tag="AB852_35850"
     CDS             complement(13834..14613)
                     /NRPS_PKS="Domain: PKS_KR (16-181). E-value: 4e-13. Score:
                     41.6. Matches aSDomain:
                     nrpspksdomains_AB852_RS36440_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006608143.1"
                     /locus_tag="AB852_RS36440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_35850"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_073795697.1"
                     /sec_met_domain="adh_short (E-value: 2.1e-33, bitscore:
                     108.9, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 8.7e-34, bitscore:
                     110.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSVTYLSELFSLDGRVALVTGGSSGIGRAVAGALARAGARVVIV
                     ARGETELAATVAELTAEGREAAWVSADLSAREGVRAAAEAAAAVFGEPDILVNSAGINL
                     RPPLGELGEDVWDTTMAVNLEAPFLLGQRFGPGMAARGFGRIIHITSQQAHRAFVQSGA
                     YGVSKGALESLARSQAEAWSPHGVTCNTLVPGFVMTPLNQRLSSDPDRVAALAARTMVG
                     RNGLAEDFAGAAVFLASGASAYVTGQSLFVDGGFSTH"
     aSDomain        complement(14071..14565)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AB852_RS36440_PKS_KR.1"
                     /evalue="4.00E-13"
                     /label="AB852_RS36440_PKS_KR.1"
                     /locus_tag="AB852_RS36440"
                     /protein_end="181"
                     /protein_start="16"
                     /score="41.6"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VALVTGGSSGIGRAVAGALARAGARVVIVARGETELAATVAELTA
                     EGREAAWVSADLSAREGVRAAAEAAAAVFGEPDILVNSAGINLRPPLGELGEDVWDTTM
                     AVNLEAPFLLGQRFGPGMAARGFGRIIHITSQQAHRAFVQSGAYGVSKGALESLARSQA
                     EA"
     CDS_motif       complement(14479..14559)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AB852_RS36440_0001"
                     /evalue="1.80E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="AB852_RS36440"
                     /protein_end="45"
                     /protein_start="18"
                     /score="20.6"
                     /tool="antismash"
                     /translation="LVTGGSSGIGRAVAGALARAGARVVIV"
     misc_feature    14749..14763
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 26.5"
                     /tool="antismash"
     gene            14845..15714
                     /locus_tag="AB852_RS36445"
                     /old_locus_tag="AB852_35855"
     CDS             14845..15714
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016208 - AMP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018892948.1"
                     /locus_tag="AB852_RS36445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_35855"
                     /product="universal stress protein"
                     /protein_id="WP_073795700.1"
                     /transl_table=11
                     /translation="MARAIAVGVDGSPESLAAVDWAAHEAALRRLPLRIVHAPWWEPRD
                     VPVTGGGDALSRAAEAVVAKAEARAAEGRPELEISSEVVAEDPVDALLGAARTAEMLVL
                     GSKGQGPVLGFLLGSYGRQVIAEARHPVVSVRSPGDRPPPRAGEVVVGQQGSAEDSGPA
                     LAFAFAAAAARGATLRAVRAWSLPPLHAYSPEFLRLTDEAGGLEPLERKSLREALAPWR
                     EKFPDVRVVEHVEIGSAGQVLLAASTGAQLLVVGRRARYTPIGGRIGSVAHAALHHAPC
                     PVAVTSHH"
     gene            15817..16626
                     /locus_tag="AB852_RS36450"
                     /old_locus_tag="AB852_35860"
     CDS             15817..16626
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (17-251). E-value:
                     2.9e-21. Score: 68.1. Matches aSDomain:
                     nrpspksdomains_AB852_RS36450_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014152913.1"
                     /locus_tag="AB852_RS36450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_35860"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_073795702.1"
                     /sec_met_domain="PF00561 (E-value: 4.5e-16, bitscore: 52.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 9.6e-20, bitscore:
                     65.2, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVRSRNHVTVSGRPGGPVVMLAHGFGCDQNMWRLIVPALERDFT
                     VVLFDHVGAGNSDLSAWSRERYSTLHGYVDDLLELCRELALGPVTFVGHSVSAMMGVLA
                     AAKEPGAFTGLVLLAPSPCFIDDPDTGYRGGFSAEDIDELLESLDANYLGWSGAMAPVI
                     MGNPERPELGEELTSSFCRTDPEIARVFARVTFLSDNRADLAGVTVPTLVAQCSRDAIA
                     PPEVGAFVHARIPGSRLVTLNATGHCPQLAAPDETAAAIAAFAGGTP"
     aSDomain        15868..16569
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AB852_RS36450_Abhydrolase_1.1"
                     /evalue="2.90E-21"
                     /label="AB852_RS36450_Abhydrolase_1.1"
                     /locus_tag="AB852_RS36450"
                     /protein_end="251"
                     /protein_start="17"
                     /score="68.1"
                     /tool="antismash"
                     /translation="PVVMLAHGFGCDQNMWRLIVPALERDFTVVLFDHVGAGNSDLSAW
                     SRERYSTLHGYVDDLLELCRELALGPVTFVGHSVSAMMGVLAAAKEPGAFTGLVLLAPS
                     PCFIDDPDTGYRGGFSAEDIDELLESLDANYLGWSGAMAPVIMGNPERPELGEELTSSF
                     CRTDPEIARVFARVTFLSDNRADLAGVTVPTLVAQCSRDAIAPPEVGAFVHARIPGSRL
                     VTLNATGHCPQL"
     gene            16626..17894
                     /locus_tag="AB852_RS36455"
                     /old_locus_tag="AB852_35865"
     CDS             16626..17894
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018960083.1"
                     /locus_tag="AB852_RS36455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_35865"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_073795705.1"
                     /transl_table=11
                     /translation="MSRTDDDQNGPRKDEVPGDEQAQFSALLEDSVEDLYEHAPCGYLS
                     TQLDGRIAKVNTTLLDWLGYRRGDLVGRKHFSDLLTVGGRLYHETHFAPLLRMQGEISG
                     IALELKAADGTRLPVLVTSTLKRGSNGQPLLVRTTLFDARDRRAYETELLRARKEADQE
                     RDRLRVLAATLQKTLLPPALENMPGLDVSTHYHLASPDEVGGDFYDLFPLAPDTWGLFL
                     GDVCGKGAAAAAVTSLARYTLRAAAVYDPDPVAVLGNLNTVLHHEYNGADPRFCTVVFG
                     LLTLDPEKGGFHITLAGGGHPPALLLRADGTADFLPTPGGQLIGVLPEAHIATTTVRLA
                     PGDTLLLYTDGLTEARTDATSGGGERYGDDALLDFARALAPATASDTVDAVRGLLDTLG
                     TGVDDDTAVLAVHAPRPPGEEQR"
     gene            17891..18250
                     /locus_tag="AB852_RS36460"
                     /old_locus_tag="AB852_35870"
     CDS             17891..18250
                     /GO_function="GO:0043856 - anti-sigma factor antagonist
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003975246.1"
                     /locus_tag="AB852_RS36460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_35870"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_073795708.1"
                     /transl_table=11
                     /translation="MTRQLTVRTRSTAAGPVVAVAGELDHLTAPEVRAVLPGLALCPGQ
                     QLVVDLGSLTFCDSTGITVLLAARNHALAAQATIALAAVPDRVSRIFRIVGLDQVFPTH
                     PTAQDAEAAWRPTPR"
     gene            complement(18362..18841)
                     /locus_tag="AB852_RS36465"
                     /old_locus_tag="AB852_35875"
     CDS             complement(18362..18841)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003946472.1"
                     /locus_tag="AB852_RS36465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_35875"
                     /product="hypothetical protein"
                     /protein_id="WP_073795710.1"
                     /transl_table=11
                     /translation="MRTWTARQWLAAAAVTVAAGAAIGIPTGVVDTPLYARMTAVLWWN
                     YPVWALSSLLVGLLVATYVGQPPAVRARGPRGPRAVAAALLSAFAVGCPVCNKLVVLAL
                     GTSGALSYWAPAQPLLAIASLALLVHALVRRLRTVADCPVPVTASSTKADGAPVA"
     gene            19548..21239
                     /locus_tag="AB852_RS36470"
                     /old_locus_tag="AB852_35880"
     CDS             19548..21239
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016827826.1"
                     /locus_tag="AB852_RS36470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_35880"
                     /product="VanW family protein"
                     /protein_id="WP_073795713.1"
                     /transl_table=11
                     /translation="MRRRIHPAAVASGAVVLGAGALYLTGLLVTGDEAPSGTTVRGVDL
                     GGLSQPEAKEKLDRELAATATAPLTVTVGDRTDRLDPAAAGLRLDTEETASRAVRSSYD
                     PFTVIGDLFTSRGGAVDPVLAMDEDATRAALRGLAEKHDRKVREGAVSFSEGAAKAVRP
                     VTGQTLDIDGSVDPVRDAYFAENPGRIELPVEEKEPRIGKAETDRALREFARPAMSAPV
                     TLTTGEGRVTIDPATFGDHLTMRPDDSQRLVPRLDEKGLYKDPAVAASVRAVTTEPVDA
                     TLRVVGERVEVARDGKPGQKVTAEALGKAVLPLLTGSGPERIGKVDTVLSQPELTRAKV
                     AEMGMTEKVSSFTANFERAEYRTKNIGRAAELINGSTVLPGETWSFNDTVGERTTENGF
                     VDGIIILDGKYTKAGGGGVSTVATAMFNAIFFAGVKPVEYGAHSFYIERYPEGREATVA
                     WGSLDLKFTNDSGKALYIATEATDTSVTVTFLGTKKYDAVEASKGPRTNVQEPKKLPGA
                     KKDCQPQTPLEGFDVTVERIFIDGGKEVKREPFNTRYTPRDEVTCD"
ORIGIN
        1 tcatccggct gcggccggcc cgcagctggc gggcggactc gctgcggacg aaaccgagct
       61 cctcgatgac ggaccggacc cggttcctgg tctcctcgga gaccaggtcg ggacggttga
      121 tcacattcga cacggtcccc acggacactc cggccgctct ggccacgtcc ttgatgccga
      181 ccatggatgc ccggtgctcc cgtcctgccg cacggcggcc cgtgtcgggc ccgagcgtgt
      241 caggttatgc cgccgcgggg ccccggtccg gacggccggt gcggcccggg gccggggctc
      301 tcccccggcg gggcgggtcg gcgtagggtg cggaccgtcc ggtgatcgcc gaaggaggaa
      361 cccgcgatgc gtgtcgccct gttcctgacc tgcgtcaacg acacgctcta cccgggcacc
      421 gggcgggccg tggtgaaact gctggccggg ctgggggtgg acgtggactt ccccctgggg
      481 cagacctgct gcgggcagcc ccagtacaac accgggtacc ggcgcgggac cgagccgatc
      541 gcccggcggc tcgcggaggt gttccgcgac cacgacgcgg tcgtcacccc gtccgggtcc
      601 tgcgcggcga tggtgcggga gatgtatccg cggctgggtg agcgggcccg cgcggagggc
      661 cggggcgacg ctctcgcgac ggccctggca ccgctcgcgg acaagacgta cgagctgacg
      721 gagttcctgg tcgacgtact gggggtgacg gacgtgggtg cctggtaccc gcacaccgtg
      781 acgtaccacc cgacgtgtca cgggctgcgt tcgctgcggc tcggggaccg gccgctgcgg
      841 ctgctgcgcg cggtccgggg gctggagctg gtggagctgc cgggcgccga ggagtgctgc
      901 gggttcggcg gcacgttcgc ggtgaagaat cccggggtgt cggtggccat gggcaccgac
      961 aaggtacgca gcgcggaggg caccggcgcc gaggtgctgt gcgccgccga caactcgtgt
     1021 ctgctgcatc tcggcgggct gctcggcaga caggggtcac ggatgcggcc ggtccatatc
     1081 gcggagatcc tggcgagcac ccgggaaggg gtacggcgat gagcgccacc cccctcggga
     1141 tgcccgcgtt cccggacgcc gcgcgggacg ccctgcggga cacgaccctg cgcggcaatc
     1201 tccggcacgc cacccacacc atccgcgaca agcgcgcccg cgccgtcgcg gaactctccg
     1261 actgggcgcg gctgcgggag gcggggaagc agatcaagga ccacaccctg cgccatctcg
     1321 accactatct gctccggctg gaggagtcgg tgacggcggc gggcgggacc gtgcactggg
     1381 ccgccgacgc cgccgaggcc aaccggatcg tcaccgagct ggtgaaggcg accggtgaac
     1441 gcgaggtcgt gaaggtcaag tcgatggcga cccaggagat cgggctgaac gaggcgctgg
     1501 cggccgaggg catccgcgcc tacgagacgg atctggccga gctgatcgtg cagctcgccg
     1561 acgaccggcc ctcgcacatc ctcgtccccg cgatccatct caaccgggcg gagatccggg
     1621 acgtcctcgc gtccgcgatg ggcgactggg ggcgtcccgc gccggacggg ctgacggacg
     1681 cgcccgccga gctggcggag gcggcccggc tgcatctgcg ggagaagttc ctgcgggcga
     1741 aggtgggggt gtccggggcg aacttcatgg tcgcggagac gggaaccatg gtcgtcgtgg
     1801 agtcggaggg caacggccgg atgtgtctga ccctgcccga gacgctgatc tcggtggtcg
     1861 gcatcgagaa ggtggtaccg gcctggcggg acctggaagt gttcctccag accctgcccc
     1921 gctcgtcgac tgccgagcgg atgaacccgt acacctcgat gtggaccggg gtgacggaca
     1981 ccgacgggcc gtccgcgttc catctggtgc tgctcgacaa cggccgcacc gacaccctcg
     2041 ccgacgaggt gggccgtcag gcgctgcgct gcatccgctg ttcggcctgc ctcaacgtct
     2101 gcccggtgta cgaacgggcg ggcggtcacg cctacgggtc ggtgtacccg ggtccgatcg
     2161 gcgcgatcct cagcccgcag ctgcggggca ccgggagcgc cgtggacgcg tcgctgccgt
     2221 acgcctcgtc gctgtgcggg gcctgctacg acgtgtgtcc cgtcgcgatc gacatcccgg
     2281 aggtactggt acggctgcgt gaacgcgtgg tcgagggcgg tccggcggtg cgccggggca
     2341 cccgggtcgt gctgcggccc gcgcgggggc acgcggcgca gcgggccgcg atgcgcgcgg
     2401 cgggctgggt gttcacccgt cccgcggcgc tggccgccgg tcagcggctg ctctcccgga
     2461 cccggcggct gcatccgcgc aggctgccgg gtccgggccg ggcgtggagc gcggaccgtg
     2521 atctgccgga ggtccccgag gagtcgttcc gcgactggtg gcggcgtacc tcgggcggcc
     2581 gcgacagcgc gggcggaagc gggcgggagg agcggtcgtg aacggcaggg aggtcgtcct
     2641 cggccgggtc cggcgggcgc tcgcggacgg gtccggcgcc tcccccgggc cggacggccc
     2701 tgtcgcctac gacggggtac gggactatct gcgcgtccat ggcgagcgca cccctgaaga
     2761 gtccgtggac ctgctcgccg cgcgtctgac ggagtaccgg gcgctcgtcc accggacgga
     2821 tgacgagggg ctgccggaac tgctgatgcg gctgctgtcc gaacagggcc ccgacgagat
     2881 gctggtgccg cccgcgctgc cgccgtactg gctgtcggcg gccgatccgg tccgtgtcca
     2941 cgaccgggcg gctctcaccg cgcgcaggct ggaccgggtg gggagcgtcg tcacgggctg
     3001 cgcgctggcg atcgccgaga ccggcacgat cgtcctggac ggcgggccgg aacagggccg
     3061 ccgccggatc accctgatcc ccgaccacca catctgcgtc gtgcgggtgc cggaccaggt
     3121 ggtctgctcg gtgccgcagg cgatcgagcg gctggacccg cgccggccgc agacctggat
     3181 ctcgggtccg tcggcgacca gcgacatcga actcgaccgg gtggaggggg tgcacggtcc
     3241 gcgcaccctg gaggtggtgc tgctgagcgg ggacggccac gcgtgtgcgg gtggtgacgg
     3301 acccggttag cgtgggggaa tgatccggtt cgagcaggtc ggcaagcgct acccggacgg
     3361 gacgacggcc gtggacgatc tgtcgttcga ggtgcgtgag ggcgagctgg tgaccctggt
     3421 gggtccctcg gggtgcggca agacgaccac gatgatgatg gtcaaccggc tcatcgaacc
     3481 gacctccggc cgcatcctga tcgacggcga ggacatctcc accgtcgacc cggtcaagct
     3541 gcgccgccgt atcgggtacg tcatccagca ggtgggactg ttcccgcacc ggaccgtcct
     3601 cgacaacacg gcgaccgtcc ccaccctgat gggctggaag aggacacggg cccgggagcg
     3661 ggccgccgaa ctgctggacc tggtgggcct ggaccccgcg ctgttcggct cccgctatcc
     3721 cgagcagctg tccggcggcc agcggcagcg ggtgggggtg gcccgcgcgc tcgccgccga
     3781 cccgccggtg ctgctgatgg acgagccgtt cggcgcggtg gaccccgtgg tgcgggagca
     3841 gttgcaggac gagttcctgc ggatgcagga cgccgtgcgc aagacggtgc tgctggtcac
     3901 gcacgacatc gaggaggcgg tccggctcgg tgaccgcatc gcggtgtacg ggcagggccg
     3961 catcgagcag ttcgacaccc cgggcgcggt cctcgggacc cccgccaccc cgtacgtcgc
     4021 ggagttcgtg ggcgcggacc ggggtctgaa gcggctgtcg gtgacggcga tcgaaccgga
     4081 cgacctggag cagcccgtgg tcgtccgcac cggtgaaccg gccgggcggg ccgccgggcg
     4141 gctgcgcggc gaggacgccc gctggggtgt ggtgctggac acggacgggg atctgcacgg
     4201 ctgggtcggc gtggacgagc tggcgctggc ggggcccggc gcgacggtcg gggacctggc
     4261 gcaccggatg aacgcgtggg tgccggtggg tgccccgctg aagcaggcgt tcggggtgat
     4321 gctccagcac gacgcgggct gggtggcggt gatcgacggg gcccggttcc tgggggtgct
     4381 caccccggcg aagttgcacg aggcgttgcg gcggtcggtc gacgcggacg cgcaaggggt
     4441 cgcgcgggac gaggtctcgt tcgactcggt gtccgacgtc tgagggtcac cctggctcgt
     4501 gcccgccccc aggccttccc acctggacgg gcttgttccg gcggggccgt tcgtgggtgc
     4561 gcggttcccc gcgcccctgg ggtcgcgacc ctcgttgtcg ccgctcgggt gcgggtcgcc
     4621 cgtggttgct cgcgcagttc cccgcgcccc tggggtcgcg cccctggacg tacctgtccc
     4681 cgtgcgggcc gttcgtgggt gcgcggttcc ccgcgctcct ttcggggcgc gtccgcagca
     4741 ggtcagagga ggcccttgtc ctctaggtag gtgcgggcca cgtcctgcgg gagtctgcgc
     4801 cagctgtcga tctgctggtt gagggaggcc agatcggccg tggtgaggac cttgttcagc
     4861 ttgtcgaggg ccttggtcgg ccccgccccg cccgcgcgcg agcggttgac gacgggcacg
     4921 atgtagtcgg cgttctggag gtgcttgtcg tcggcgagga tgaccagccc gaactgggcg
     4981 agcgtcgcgt cggtcgtggt ggtgaggacc atctggtcct gcccggactg cacggccttc
     5041 ttggcctggg tggtgccgac gcccttgggg tcgataccgg tgatgtcgat cccgtacacc
     5101 ttcttgaggc cgggctcgca gtacggccgc ttcacgcact cgtccccggc ggcgagccgc
     5161 accttcagcc ccgaccgccc gaggtcgctg agggtcttca gccggtgctc gcgcgcgtac
     5221 gacgcggcca ccgcgaacgc gttctggtcc acggcgcggc ccggatcgag gacggtgagc
     5281 ccccggggcg tggcgagacg gcgcagattg tccatggtgg tcgtcagatc gggggacccg
     5341 gcgggcgggg cgtcggggcc gttcgccttg gcgttgagcc agtcggcgaa ggtggcggcg
     5401 tactccggga cgacatcgat ctgtccggac tccagggccg gttcgtacag ctcgcggttg
     5461 gcgacggtga gcgtccgggt ggagtagccc gcgtgcttga gcagcagggc gtacatctgg
     5521 gcgaggacgt cgctctcggt gaagcccgcc gagccgacga cgaggttctt gttgtcgccg
     5581 ggtgaggcgg ccaccgcgtc ccgggtctcc agggacggtc cgccggcgca gccgccggcg
     5641 gtgaggcaga gcagggcgag gacggcggcg ggggccgcgc ggcggttcat ccgccgcgcc
     5701 cggcgcgggc ccggttcggc gccagccgtt ccacggcctc gaagacgcct tccaccagca
     5761 gcgcgaacac ggcgacgagg acggcgcccg cgacgacctg cggggtgctg gcgaggttga
     5821 acccggcggt gatgatccgt ccgagtccgc cgccgcccgc gagcgcggcg atggtcgcgg
     5881 tggcgacgag ctggacggcg gcgatccgga ccccgctgag caccatcggc gaggcgagcg
     5941 gcagctcgac ccgcagcagg acctgccgtc ccgtcatccc catgccgcgg gcggcccgca
     6001 cgacgtcctg gtcgacgccg cgcatcccga cgtaggcgtt ggtgagcagc ggcggtaccg
     6061 cgaacagcac cagggcgatc acggtcgggc cctccccgta ctcgccgacc ggggtgagca
     6121 gcagcaggac gaggacggcg aaggtgggga cggcccggcc gacgttggag atgttgacgg
     6181 cgagcgcgcc gcccttgccg agatggccga ggaccagggc gacgggcagg gcgatcagac
     6241 agctgatgac gaggcagacg acggtcagca ggaagtgctg gagcagccgg tgccagacgc
     6301 cgtcgtcccc ggaccagtgg gcggggtcgg cgagccactg ccaggcgtcg gtgagggtgg
     6361 tcagggccgc cgcctcccct ggtcggcgct catgcgcggg cggcccgggt ccagggggtc
     6421 agcagccgct ggacgccgag gagcaggagg tcggccgcga ccgcgatgac gacgcagagc
     6481 acggacgcgg tgaggacctg ggccttgaag taggtattca tccccgcgta gatcagattg
     6541 ccgaggccgc cgaagccgac gatggcgccg acggtcacca gggacaccgc ggagacggtc
     6601 gcgatccgca gtcccgccat cgaggcgggc agggcgagcg ggagttccac ggtgagcagc
     6661 agccggaccg gtccgtagcc gaggccgcgg gcggcctgcc gggtctcctc ggggacgccg
     6721 cgcaggccga cgaggatgtt ccggacgagc agcgtcagcg agtagaggac gagtccggcg
     6781 accaccaggg acgcggacag cccgtacgcg ggcagcagca gggagaacat cgccagcgac
     6841 gggatggtgt agaggacggt ggtgacggcg aggacgggcc ccgaggccca gcgccagcgc
     6901 cgtgcggcga cggccagcgg gacggcgacg accagggcga tcagcaccgc gaggaaggtg
     6961 agctggaggt gctggacggt cgcgtcggtg aggatatggc tcctggtcgt caggtactcg
     7021 ccgcagatcc agtcgttgcg ggcgaggcag tcgtccggcg gggtcatctg cccattccag
     7081 cggcgcggcc gcggggtcgc ccgtcggggt gggccgtccg ggggctcccg ggccactcgg
     7141 gggtggtgaa cggcgccggg tcggcccaac ggaatgcggg gtttgcgccg gggccgggca
     7201 cagatgtcac accggtgccc cggaatccgt ccgcgcgccg ccccgagccc cgctcctcgt
     7261 cgtcgaaagg ccccctcccg tgcccgcgag ccccacccgg acgttccgga cccgccctgc
     7321 cgtccggacc gtcgcccgga cctcccgttc caccggtacc gctcgtaccg tccgtgccac
     7381 ccgttccgcg ctggccgcgc tctcgtgcgg tgccctgctg ctcaccggct gctccgccgg
     7441 ggccgggtcc ggacgggccg ggggcggtgg tccggccccg ttgaacgcca aggcgggcag
     7501 tgcgacgggc ccgtcggccc ggcccccgat cgaggggcgc cccgggccgg gcacggccgg
     7561 tgaggtcgcg gcggtccccg ggctcgggcc ggggacccgg gcccggattc cggcccgtac
     7621 ccggcaggcc ctcgtggtga ccggcgccgg acgggactcc agcgcgggca cggccgcgct
     7681 gcaccagcag ggcgcccagg gcgtctggcg caccgtggcc ggaccctggc ccgcgcacaa
     7741 cgcgctgcgc ggctggacgg acgaccaccg ggcgggcgat ctgcgcagcc cgatcggggt
     7801 gttcggcctc ggtgacgcgg gcgggctgtt gcccgacccg ggcaccgcgc tgccgtacga
     7861 ccaggacatc gagttcggcg actccggcac gggctacctc gacgagtcgc tggaaggctc
     7921 cttcgactac gtcctggcga tcgactacaa ccgggtgccc ggtacgtcgc cgctcgacaa
     7981 gacccggccg ctgggcgcgg acaagggcag cgggatctgg ctccatgtgg accacggcgg
     8041 ccccaccaag ggctgtgtgt cgctgccgcg cggccggatg cgggagctgc tgcgcgcgct
     8101 ggacccccgg ctgcggccgg tcgtggtgat gggtgacgcg gcgtcactgc gcggctgacg
     8161 tccacggcgg gcgggctccg acatcggcca cacgggtgcg ctcaccgacc gcctcaccac
     8221 tcttgtcggc cccccgcggt ccccctgacc ggcgccccgg tgccggtcgg cggtcgcctc
     8281 cggtcgcgcc ggacgcctct gccgcctcgg tcgccgccgg gacacgaggg gccgtcgtgg
     8341 gtcacttgag ggagcgcagc atgaacgagt gcccggcggg gtcggacagc agccgcccct
     8401 cacgggtggt gccccggccc tgtacgtcca tcggggtggc cccgagactg accgcctcgc
     8461 gctcggcctc gtcgaggtcc gaccgcgcca ccatgatcag cagatgtgcc tgctgcgcgt
     8521 cctcgggccg gggccagctc gggggcgcga agccgtggtc gcgctggaac cccagcacgg
     8581 atccgtcctc gcccctcacc tccacgaggt cggggtcacc ggtcgggcgt atctcaccgc
     8641 cgagcagggc cgcgtagaac tccgcgagcg cctcggggtc ggcgcagtcg agcgccagga
     8701 cggccgtctt gggtacaggc atctttcctc cagttggccg tgggtcacct tgggccgtct
     8761 acccgcgttc acacacctca tgcggtacgg gaacgtcggc gttccgcccg gcggaacacc
     8821 ggcgccgagg caacggacga gcggcccgaa atcccgttca tggcacggag ttccggcccc
     8881 cgggaatgct ccgggcaaag gaccggcgga atcgcggacc agcggaccat cacactttga
     8941 ccccgcgcgg gtgaatggat cggggatgcc gggaacggcc cggatcgggc atgccacagt
     9001 tccggtgcgc gccgctcgac ggcgacgccc tcacggttcc cggcgcttcg cgaacaccgc
     9061 gtcacgggga ctctcttgag tgcggttcgg ggttcggaga ggaagtcgtt gtccacccag
     9121 cagtcatcag ccgtcatgcg tgtgctccgt acccggagtg cggtgcggca gttcaccgac
     9181 caacccgttt cggacggcca gttggagcaa ttgatcgacg ccatactggc cgcccccacc
     9241 ggggggaaca agcaggcctg ggccttcgtg gccgtgcgcg acccgcgcac cctgcggctc
     9301 gtacgggctt tctcccccgg gatgatcgag ccgccgccgc tcgtcgtggt cgcgtgcttc
     9361 gaccgttccc gcgcggtcaa ggacgacggc gagttctggg acgagggact gctgtgcgtg
     9421 gcgatggcgg tgcagaacct gctgctcgcc gcccattccc tggggctggg cggctgtccc
     9481 gcggccagtt tccggcgtgg ttccgtcgcc acgatcctcg ggttgcccag ccatctcgaa
     9541 cccctgctcc tggttcccct cggccacccg gccagggatc tcgtatcacc gccccgccga
     9601 gaccgcagtg aggtagtcag tcatgagttc tggggaaacg gcactccggc cgatcgatga
     9661 ggaactcctc cttctcaccg cgtatctgct cagcagcggg cggggacttc tggaggagcc
     9721 ccagcagtac ggccccttcc gctgcatcga cgccgcccgg cgggtactgg tgctgctccg
     9781 ggaccgcggt gtgaccaaca gcgaactcca ggaactgcac ggccggttgg aggatttcat
     9841 gtgcgggccg atggctccca gggatctcac cgcgttcctc gacgaggtgt gcgggaagct
     9901 gacactgctg ctgcgggact ccgatctcat ccggcggggt ccggcttccc ccgccaccac
     9961 ctgacggcgg ggaatccgaa cggccgaggg aagcagagac atgacgaagt tcgaggtgga
    10021 acccgtcacc ccgacctgtc ggcggatcta tgagcgcggt gaccacgcgc tgatcggcgt
    10081 gagtgccggg aacagctatt tccatcagga acggctgggt tcgctgctgg cctgggcgga
    10141 agaacacttc accctggtcg acgtcctgta catcgacacc catatcgacg ccatgctcat
    10201 cgcgacggga ctcaccccgg cccaggccgg cagtcgcacc agaagcatgc tcaaggatgt
    10261 ccggcgaaga atccggcgtg ccctggagaa gacctcggga accgcgcacg ggcggctccg
    10321 ggtgcggtcg atgtcggaat gcgcgcaact tcccgcgtat caggaggtgc tgcgccggct
    10381 ggaccgggat ttcgacgaca gcgggccggt gcggcgggcc gccgaggaac aggtacgcga
    10441 actcctcgaa caccattccg gccccgtcac ggagcactcc gccgattccg tgcagataca
    10501 ggcgggactc gcgtacgtcc gctcggagat ccccttcctg ctcgacaccc ccgccattct
    10561 gggcgtcccc tcctcggtca cctgctatca caagctgatg ccggtggtca ccgcgctcta
    10621 ccaggaaccc gggagccccg ggcgcagccc ccggcagggc ttcctcgtcg tcagcccgga
    10681 accggtcgcc gcgccggatt ccccgcccca gcagacccgt tcacgtacaa ggagagagca
    10741 gttgaccctc acggagcagt acgacgagat cgcggcggac tacaccgatg tggagcgggt
    10801 gttcagcacc taccgcagcc tcatcgagat cccgtcgctc ctgcgtgccc tcggcccggt
    10861 cgagggggcc tccgtactgg acctcgggtg cggttccggg gcgtacgccc ggctgctgcg
    10921 gcgccggggc gcggccgagg tgctgggtgt ggatgtgtcg cccggcatga tcgaggtggc
    10981 gcgggcgctg gaggagcggg agccggtcgg ggtgcggtac gaggtcgtgg acgcggccga
    11041 catgcccgtc ctcggcacct tcgacgccgt ggtggcggtc gcggtcctgc actacgcgga
    11101 cagccgggcg acgctggccc ggatgatgag gcagacctgg gccaatctgg cgcccggcgg
    11161 ccgcttcctc gcctatgtgg gcaatccccg gctcccggcg gacagcgccc agatgaacgg
    11221 tctcgtggtg caccgccccg acaacgcccg cgacggtgac ccctcgcccc tcacgatccc
    11281 cacgactccc ccgacgacgc tgcccgcgcg gtactggagt tgcgagacca tcgagaagac
    11341 cctgcgggcc tccgggttca ccgatgtggt gtgggagccg ctggacggtc tgccgtcggg
    11401 tgcgcaggag ccggtgaacc tgctcgtcag cgctcgcgcg cagcccgtgg gcgcggcgga
    11461 ggccgtcgct ccgtccgccc atgagcgggc tccgctggcg gccacggctg ctcagtagcc
    11521 gtcccgggcc cgcacgcccg tgtcgccccg ggatcagagt gcggcgaggg cgctgtccgc
    11581 gacggcgagc agcgcctgcc ggtccttctg gacccgggcg aggacccgca gcccgtagta
    11641 cgtgctgagg acctggcggg cgagggtgcg cgcgtcgccc ggtgcggtga tcccgccgtc
    11701 gcgctgccct tccgccacgg tgtcggtcaa ggcgtcctcc acggcgccga agtgacgctg
    11761 gagttcctcg gcgacgtccg ggtcctcgct gcccatctcg atcagcgcgt tgaccgcgaa
    11821 gcagcccgcg ggtccggtcc cggacaggtc caggtcgacc gcgtggacca tgaggtggcg
    11881 cagccgttcc ttggccggtc ccggtgcgcg cagcccgcgg gtctgttcgg cggtgtggac
    11941 ggcgaagtac tcgcgcaggg tccgcagata gagctgccgc ttgtcgccga aggtgttgta
    12001 cagactggac ggtccgacgc cggtgcggtc ggtcaggtcc ctggtggacg tcgcgtggta
    12061 gccctgccgc cagaaggcgt ccatcgcgga gccgaccgcc cgggcctcgt cgaacttccg
    12121 tggccgtgcc atgacgcgat cgtaggggtt ctgaagcgac cgcaccaaac ccccggttct
    12181 cgcctctcaa cggccccgcg ccatgcgcgc cttggcctcc ggcggccttc cgccagttct
    12241 gaagcggacg cttcaaaaca tgctagcgtc cttcgggccg ggcacaccgc gacgtcgaac
    12301 gccgctgtgc cgtatcggcg ttgacctgtc caccgcggca ccgcccgtac accggaggaa
    12361 cactcatgcc cttagccgtc tacgtcctcg gactggggat cttcacccag ggaacctcgg
    12421 agttcatgct ctccgggctg ctcccgggga tggccgacga tctgggtgtc tcgatccccg
    12481 acgccgggtt gctcatctcg gccttcgcga tcgggatggt cgtcggcgcg cccctgctcg
    12541 ccgtcgccac actgcgctgg ccgcgccgca ccgcactcgt cgccctccag ggcgtgttca
    12601 tcgccgcgca cgtcgtcggc gcgctggcgc ccggctacgg gccgctgttc gccacccgga
    12661 tcgtcagcgc cctcgcctac gccgggttct ggggggtggc ggtggcgacc gccgtggcgc
    12721 tcgtaccggc ggacgcgaag gccagggccg tcgcggtggt ggcgggcgga ctgaccctgg
    12781 ccaccatcgt gggcgtcccg gcgggtacgg tgctcagcca gttcgccgga tggcgcgcgg
    12841 ccttctgggg cgtcgccgtc ctgaccctcg tcagcctcgt ctgcacggtg ttcgccgtgc
    12901 ccggcggcaa gggcgcgcgc gaggagcccc ggacggtccg cgcggagctg cgggccatgc
    12961 ggcggcccca gctgtggctc tcgtacgccg tcacggcctt cgccttcggc gcggtcatcg
    13021 tcaccttcag ctatctcgcc gcgctgctga ccggcgtgag cgggatgtcc gaggggtggg
    13081 tgcccgtggt gctggcgctg ttcggggtcg gcgggctggt cggtatgacg atcggcggac
    13141 ggcagcccga ggaacggtcc gtgccgacgc tcgtcgccgg actcgcggtg ctgaccgtgg
    13201 cctccgccgc gctcgcgctc acggcccggc acaccgccgt caccctggtg ctggtcttcg
    13261 tcctcggcct ggccggatat gtcaccaacc cggccctcca ggcccgggtc ttcaccctcg
    13321 caccgggcgc cccgaccctc gtcggcgcca ccaacacggc cgccttcaac atcggcaaca
    13381 ccctggcccc ggcactgggc ggcgcgacga tcgcggcggg ctggggctat ccctcggtcg
    13441 cctgggtcgg cgccgcgctc gccctcctcg gactggccgg ggcgctgtgg gcgggggcgc
    13501 tggagcggcg cgaccgccgt accggcatac ccgccgtacc gacggcgtcc cggcggacgg
    13561 cggaacacgc cgacgcctga cggtgtccgc gccgcacccg gtcctcggga ggggaccggg
    13621 cgcggcgggg cgggacggtg cgtggccggt cggggcgtcg acggtcgcgg cgaggcgggt
    13681 cagcgggcca ccggcccgca cgtggtcggt cagtaggtcg ccggtggacg cggtcgccgg
    13741 gcggagggcc gccgatcgga aggccgtcgg tccgcgcgtc gccgggtcgg tgggccgccc
    13801 gtacccgcgt cgccgggtcg gtgggccgcc aggtcagtgg gtcgagaagc cgccgtcgac
    13861 gaagagggac tggcccgtca cataggcgga cgccccgctc gccaggaaca cggcggcgcc
    13921 cgcgaagtcc tcggccaggc cgttgcgtcc gaccatggtg cgggcggcga gcgccgccac
    13981 ccggtcgggg tcggacgaca gccgctggtt gagcggggtc atcacgaaac ccggtaccag
    14041 ggtgttgcag gtgacgccgt gcggtgacca cgcctcggcc tgcgagcggg ccagcgactc
    14101 cagcgcgccc ttggagacgc cgtacgcgcc gctctgcacg aacgcccggt gcgcctgctg
    14161 cgaggtgatg tggatgatcc ggccgaaccc ccgcgcggcc atcccggggc cgaagcgctg
    14221 ccccagcagg aacggtgcct ccaggttcac ggccatggtg gtgtcccaga cgtcctcgcc
    14281 cagctcaccc agcggaggac ggaggttgat gcccgcgctg ttcaccagga tgtccggttc
    14341 cccgaacacg gccgccgccg cttccgccgc cgcgcgcacc ccctcgcggg cgctcagatc
    14401 ggcgctcacc caggccgcct cgcggccctc ggccgtcagc tcggccacgg tcgccgcgag
    14461 ttccgtctcg ccgcgcgcca cgatcaccac ccgggcgccc gcccgcgcca gcgccccggc
    14521 caccgcccgg ccgatccccg agctgccgcc cgtcaccagg gccaccctgc cgtccagtga
    14581 gaacagctcc gagaggtacg tcaccgaggt catcccggca gcctagtggt gagccccgca
    14641 cgcccgccgg tgggtaccgg gcggcggcgg gaaggcgccc gccctcgtgg gatccggcac
    14701 ggccgcctgg gacgccaggg cggccccgac cggccggttc ctggattcgg gacgatcggc
    14761 cctcccccgg cgggccatga tccggaaggc tgcggggagg ggcggtagcg ttgccgctcc
    14821 gtcgcgtcac aaggaggcat ggcaatggcc cgcgcaatcg ctgttggggt ggacggctca
    14881 ccggagagtc tggcggccgt cgactgggcg gcccatgagg cggccctgcg gcggctcccc
    14941 ctgcgtatcg tccacgcccc ctggtgggag ccgcgcgacg tcccggtgac cggcggcggg
    15001 gacgccctga gccgcgcggc cgaggccgtc gtggcgaagg ccgaggcacg ggcggccgag
    15061 gggcgcccgg agctggagat cagctccgag gtggtcgccg aggacccggt ggacgccctg
    15121 ctcggcgccg cccggacggc ggagatgctg gtgctcggct ccaagggaca gggccccgtc
    15181 ctgggcttcc tgctcggctc ctacggccgg caggtgatcg cggaggcacg gcaccccgtg
    15241 gtctccgtcc ggtcccccgg ggacaggccg ccgccgcgcg cgggcgaggt cgtcgtcggc
    15301 cagcagggca gcgccgagga cagcggaccg gcgctcgcgt tcgcgttcgc ggcggccgcc
    15361 gcgcgcggcg ccaccctgcg cgcggtacgg gcctggagcc tgccgccgct gcacgcctac
    15421 agccccgagt tcctgcggct caccgacgag gccggcgggc tggagccgct ggagcgcaaa
    15481 tccctgcgcg aggccctggc gccctggcgc gagaagttcc cggacgtccg cgtcgtggag
    15541 catgtggaga tcggcagcgc cggtcaggtc ctgctcgccg cgtccaccgg ggcacagctg
    15601 ctggtggtgg ggcgcagggc ccggtacacg cccatcggcg gccgtatcgg ttcggtggcg
    15661 cacgcggcgc tgcaccacgc cccctgcccg gtggcggtga cctcgcacca ctgacggttc
    15721 cggcggggcg gcgaccgggg tgccggggcc gacggcgcgc gcacccggtg gcatgctccg
    15781 cgggcggcct gggcggtctc tgcgagtatg tgccatatgg atgtgcggag caggaaccat
    15841 gtgacggtgt cggggcggcc cggcggccct gtggtgatgc tggcgcacgg gttcgggtgc
    15901 gaccagaaca tgtggcggct gatcgtgccg gcgctggagc gcgacttcac cgtcgtcctc
    15961 ttcgatcatg tcggcgcggg gaactcggac ctctcggcat ggagccggga gcggtactcg
    16021 accctgcacg gatacgtcga cgacctgctg gagctgtgcc gggagctggc actgggcccg
    16081 gtgacgttcg tcgggcactc ggtcagcgcc atgatgggcg tgctggccgc cgcgaaggag
    16141 cccggggcgt tcaccgggct cgtcctgctg gccccgtcgc cctgcttcat cgacgacccg
    16201 gacaccggct accggggcgg gttcagcgcc gaggacatcg acgagctgct ggagtcgctc
    16261 gacgccaact atctgggctg gtcgggtgcg atggcgccgg tcatcatggg caacccggag
    16321 cggccggagc tgggcgagga actgacgagc agcttctgcc gtaccgaccc ggagatcgcc
    16381 agggtcttcg cccgggtcac cttcctgtcc gacaaccgcg ccgacctcgc cggggtgacg
    16441 gtgcccaccc tcgtcgcgca gtgctcccgt gacgcgatcg ccccgcccga ggtgggcgcg
    16501 ttcgtgcacg cgcggatacc gggcagccgg ctcgtcacgc tgaacgccac cggacactgc
    16561 ccgcagctcg ccgcccccga cgagaccgcc gcggcgatcg ccgcgttcgc gggaggcacc
    16621 ccgtgatgag caggaccgac gacgaccaga acggtccgag aaaggacgag gtcccggggg
    16681 acgagcaggc gcagttctcc gcgctgctgg aggacagcgt cgaggacctc tacgagcacg
    16741 ccccgtgcgg ctatctctcg acccagctgg acggccggat cgcgaaggtc aacaccacgc
    16801 tgctggactg gctcggctac cggcgcggtg acctggtcgg ccgcaagcac ttctccgacc
    16861 tgctgaccgt cggcggccgg ctctaccacg agacccactt cgccccgctg ctgcggatgc
    16921 agggcgagat cagcggcatc gccctggagc tgaaggccgc cgacggcacc cgcctgccgg
    16981 tcctggtcac ctccaccctg aagcggggca gcaacgggca gccgctgctc gtccgcacca
    17041 cgctcttcga cgcccgcgac cggcgcgcct acgagaccga gctgctgcgc gcccgcaagg
    17101 aggccgacca ggaacgcgac cgcctccggg tgctggccgc caccttgcag aagacgctgc
    17161 tgccgccggc gctggagaac atgccgggcc tggatgtctc cacgcactac catctcgcct
    17221 ccccggacga ggtcggcggc gacttctacg atctcttccc cctggccccg gacacctggg
    17281 gcctgttcct gggcgatgtg tgcggcaagg gcgccgccgc cgcggccgtc acctccctgg
    17341 cccgctacac cctgcgcgcc gccgccgtct acgaccccga cccggtggcc gtgctcggca
    17401 acctcaacac ggttctccac cacgagtaca acggtgccga tccccggttc tgcaccgtcg
    17461 tcttcggact gctcacgctc gaccccgaga aaggcggttt ccacatcacc ctggccggtg
    17521 gcggacatcc gcccgccctg ctgctgcggg ccgacggcac cgccgacttc ctgcccaccc
    17581 ccggcggaca gctcatcggt gtcctgcccg aggcccatat cgccaccacc accgtgcgcc
    17641 tcgcccccgg cgacaccctg ctgctgtaca ccgacggcct caccgaggcc cgcaccgacg
    17701 ccacctccgg cggcggggaa cgctacggcg acgacgccct tctcgacttc gcccgcgcgc
    17761 tggcccccgc caccgcgtcg gacaccgtcg acgcggtccg cggcctgctc gacaccctcg
    17821 gcaccggcgt ggacgacgac accgccgtcc tcgccgtcca cgcgccccgg ccccccggtg
    17881 aggagcagcg gtgaccaggc agctgaccgt ccgtacccgc agcacggccg ccgggccggt
    17941 cgtcgcggtc gccggggagc tcgaccacct caccgcgccg gaggtacgcg ccgtgctgcc
    18001 cggactggcg ttgtgtccgg gccagcagct ggtcgtcgat ctggggagcc tcaccttctg
    18061 cgactccacc ggcatcacgg tcctgctcgc cgcccgcaac cacgccctgg ccgcgcaggc
    18121 gaccatcgcg ctggccgcgg tccccgaccg ggtcagccgg atcttccgca tcgtcggcct
    18181 ggaccaggtc ttcccgaccc atcccaccgc ccaggacgcc gaagccgcct ggcgccccac
    18241 gccgcgctga ccgtcgggcg cccctcggcc cacggctcca cgaagacgta cgcctcagac
    18301 gccccccggg tgcgcccccg cgaggcgtca cgggagcgcc cgtggtccgc gcggccgtcc
    18361 gtcaggcgac cggtgcgccg tcggccttgg tggacgacgc ggtgaccggc accgggcagt
    18421 cggccaccgt gcgcagccgc cgcaccaggg cgtggacgag cagcgccagt gaggcgatcg
    18481 cgagcagggg ctgcgcgggg gcccagtagg acagggcccc gctcgtgccg agggcgagga
    18541 cgacgagctt gttgcagacc gggcagccga ccgcgaacgc ggacagcagg gcggcggcga
    18601 cggcgcgcgg tccgcgcgga ccccgggccc ggaccgcagg cggctgaccc acgtacgtcg
    18661 ccaccagcag tcccacgagc agcgaggaca gcgcccagac cgggtagttc caccagagca
    18721 cggcggtcat ccgggcgtac agcggggtgt cgacgacccc ggtcggaatc ccgatcgccg
    18781 caccggcggc caccgtcacc gccgccgcgg ccagccattg acgtgctgtc caggtccgca
    18841 tcggtccgcc tccctcagct ccgtgcccgt cgccgtggca cgtgctaccg cgtacgcgtg
    18901 gtcgccgtgg agtcctcccg gcgcgacgca tgtgggaacc accttagtag atccgttgat
    18961 catcgcactc cctcccccgg ccgccggtac ggctcaccgc acccgcaaca ggcgccgccg
    19021 gtccggatca tgggggtcgc cgttcatgat ccgtcgcccg atacgaccgt cacgatccgg
    19081 ccattgatct tctacacacc gtagtaggtc ggcgcgggcc gcgagcgcgg tgccgggtac
    19141 ggcgcccgtc gcggggttcg cgctggacgg cgcggaagcg gggtgctccc gtgtcggtct
    19201 tgtcacgccc accggggagg gcggggccgg gggtttccac gtccggcgcg gtcggcggcc
    19261 cggcgcgcgg cgcggggcag cggacggccg tcatctcacg gcgtgcgaac tgccgccggg
    19321 tgagggcccg caggccgggc gggcggggcc gggccggggg cgcggggacg gtgtccgggc
    19381 ggcgaagcgg ggaaggcgac gatagcggcc ggtgggccgg tggccggtta tccctacctc
    19441 cgtttcttac tattcgctta cttatggcac ggtagcgtcc agtgcgttcg tcacaccggc
    19501 cgggccatgt ccggactgat ccgtgccggt catcttctgg gagtcccatg cgccgccgaa
    19561 tacatcccgc cgccgtcgcg agtggcgctg tcgtgctcgg cgcgggggcc ctctatctga
    19621 ccgggctgct ggtgaccggc gacgaggctc cctccggcac cacggtgcgc ggggtggacc
    19681 tcggtgggct gagccagccg gaggccaagg agaagctgga ccgggagctg gcggccacgg
    19741 caacggcccc gctcacggtg accgtcgggg accgtacgga ccggctcgac cccgcggcgg
    19801 ccgggctccg gctcgacacc gaggagaccg cctcccgcgc ggtccgctcc agctacgacc
    19861 ccttcacggt gatcggtgat ctgttcacct cccgtggcgg cgcggtcgac cccgtgctcg
    19921 cgatggacga ggacgccacc cgggccgccc tgcgggggct cgcggagaag cacgaccgca
    19981 aggtccgtga gggcgccgtc tccttcagcg agggcgcggc gaaggcggta cggccggtca
    20041 ccggccagac gctggacatc gacggatcgg tcgacccggt gcgggacgcg tacttcgccg
    20101 agaaccccgg gcggatcgag ctgcccgtgg aggagaagga gccgaggatc ggcaaggccg
    20161 agacggaccg cgcgctgcgc gagttcgcgc ggcccgcgat gtcggcgccc gtcacgctca
    20221 ccaccggtga ggggcgcgtc acgatcgacc cggcgacgtt cggcgatcat ctgacgatgc
    20281 ggcccgacga cagtcagcgt ctcgtcccgc gactcgacga gaagggcctg tacaaggacc
    20341 cggccgtggc cgcctcggta cgcgcggtga cgacggagcc ggtcgacgcc acacttcgcg
    20401 tcgtcggcga gcgcgtcgag gtggcccggg acggcaagcc ggggcagaag gtcaccgccg
    20461 aggccctggg caaggccgtg ctgccgctgc tgaccggctc gggaccggag cgcatcggca
    20521 aggtggacac cgtcctctcc cagcccgagc tcacccgggc gaaggtcgcg gagatgggga
    20581 tgacggagaa ggtgtcgtcc ttcaccgcga acttcgagcg cgccgagtac cgcacgaaga
    20641 acataggccg ggccgccgag ctgatcaacg gttcgacggt gctgcccggg gagacctgga
    20701 gcttcaacga caccgtgggc gagcgcacca cggagaacgg tttcgtcgac ggcatcatca
    20761 tcctcgacgg caagtacacc aaggccggtg gcggcggtgt ctccaccgtg gcgacggcga
    20821 tgttcaacgc gatcttcttc gcgggggtca agcccgtgga gtacggcgcg cactccttct
    20881 acatcgagcg ctatccggag ggccgggagg ccacggtggc gtggggcagc ctcgacctga
    20941 agttcaccaa cgactcgggc aaggccctgt acatcgccac ggaggccacc gacacctcgg
    21001 tgacggtgac cttcctcggc accaagaagt acgacgcggt cgaggcgagc aagggaccgc
    21061 gtaccaatgt ccaggagccg aagaagctgc ccggcgcgaa gaaggactgc cagccgcaga
    21121 ccccgttgga agggttcgac gtgaccgtcg agcggatctt catcgacggt ggcaaggagg
    21181 tcaagcggga gcccttcaac acccgttaca ccccgcgcga cgaggtcacc tgcgactgat
    21241 cccgcccggg agcgcacggc accgggaccg tccccgccgg accggtacct tccaccgcac
    21301 ccgcacccgc acccgatacc cggacccgga tcgtccaccg acggccgccc cgcgcagcac
    21361 ttcgcgcggg gcggccgttt cggtcccgtc ccagccggtc gtcgcagcag gtccgtccgc
    21421 cgggtcccgg cccgccggtg gcgtcagccg acggtgaagg tgccggatgt gccggtgaag
    21481 ggggtgatcc ggccccagaa gttcttcgcg tcgccgtg
//
