LOCUS       NZ_LFBV01000005        10399 bp    DNA     linear   CON 03-MAY-2024
DEFINITION  Streptomyces uncialis strain DCA2648 scaffold5, whole genome shotgun
            sequence.
ACCESSION   NZ_LFBV01000005
VERSION     NZ_LFBV01000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces uncialis
  ORGANISM  Streptomyces uncialis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 540574)
  AUTHORS   Yan,X., Huang,T., Ge,H. and Shen,B.
  TITLE     Cloning and characterization of the uncialamcin biosynthetic gene
            cluster
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 540574)
  AUTHORS   Yan,X., Huang,T., Ge,H. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-JUN-2015) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33410, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 19-MAY-2015
            Assembly Method                   :: CLC Genomics Workbench v. 8.0.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905345.1-RS_2024_05_03
            Annotation Date                   :: 05/03/2024 03:03:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,456
            CDSs (total)                      :: 7,371
            Genes (coding)                    :: 7,214
            CDSs (with protein)               :: 7,214
            Genes (RNA)                       :: 85
            rRNAs                             :: 6, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1 (5S, 16S)
            partial rRNAs                     :: 5 (23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 157
            CDSs (without protein)            :: 157
            Pseudo Genes (ambiguous residues) :: 0 of 157
            Pseudo Genes (frameshifted)       :: 42 of 157
            Pseudo Genes (incomplete)         :: 143 of 157
            Pseudo Genes (internal stop)      :: 7 of 157
            Pseudo Genes (multiple problems)  :: 33 of 157
            CRISPR Arrays                     :: 14
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:56:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 75909
            Orig. end                         :: 86308
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LFBV01000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10399
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="1"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10399
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10399
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5399](+)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5399
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     misc_feature    94..107
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.74"
                     /tool="antismash"
     gene            complement(139..1230)
                     /locus_tag="AB852_RS20650"
                     /old_locus_tag="AB852_20310"
     CDS             complement(139..1230)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003960017.1"
                     /locus_tag="AB852_RS20650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_20310"
                     /product="amidohydrolase family protein"
                     /protein_id="WP_073791594.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 1.9e-21, bitscore:
                     71.4, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDRTVLHVSGRVLVGPDDVRDELWVVGGRITYERPAGVRDTVTV
                     RGWALPGLVDAHCHVGLDAHGPVPAATAEKQALTDREAGALLIRDAGSPSDTRWIDDRE
                     DLPRIIRAGRHIARTRRYIRNYAHEIEPADLVAYVAQEARRGDGWVKLVGDWIDRDAGD
                     LTACWPRDAVRAAIAEAHRLGARVTAHCFAEDALRDLVEAGIDCVEHATGLTEDTVPLF
                     AERGVAIVPTLVNIATFPRLADGGESKFPRWSAHMRRLHARRYDTVRAAYDAGVPVFVG
                     TDAGGSLPHGLVADEVAELVTAGIPPVEALSATTWGARRWLGRPGLTEGAPADLVVYET
                     DPRADVRVLAAPRRVVLRGRIVG"
     gene            1357..2400
                     /locus_tag="AB852_RS20655"
                     /old_locus_tag="AB852_20315"
     CDS             1357..2400
                     /NRPS_PKS="Domain: Aminotran_5 (17-280). E-value: 1.4e-27.
                     Score: 88.5. Matches aSDomain:
                     nrpspksdomains_AB852_RS20655_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018104676.1"
                     /locus_tag="AB852_RS20655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_20315"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_073791597.1"
                     /sec_met_domain="Aminotran_5 (E-value: 2e-22, bitscore:
                     74.4, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSHPLLDLAPLTADRFAAIERRVAGLLATEQDVVITQGEALLPLE
                     GCIRGAAGPGTTALNVITGPYGQTFGDWLRDCGAKVIDLAVPYHAAVTPEEVERALADR
                     PEIDFVSLVHAEAATGNTNPVAAIGEVVRRHGALFMLDAVASVAAEPLLPDAWGVDLCV
                     IGAQKAMGGPAGVSAVSVSERAWARMAANPQAPRRSYLSLLDWKERWIDAGRRALLHAP
                     AQLEMLALEACVERIESVGPDIVMARHAAAARATRAGATALGIGLEPYVTEARDAAPVA
                     TTLRVPADADASAVVARALALDPGLPLVAGGGALAREMVRVNHYGPDATDEVVERSLAA
                     LAGALSG"
     aSDomain        1408..2196
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AB852_RS20655_Aminotran_5.1"
                     /evalue="1.40E-27"
                     /label="AB852_RS20655_Aminotran_5.1"
                     /locus_tag="AB852_RS20655"
                     /protein_end="280"
                     /protein_start="17"
                     /score="88.5"
                     /tool="antismash"
                     /translation="AIERRVAGLLATEQDVVITQGEALLPLEGCIRGAAGPGTTALNVI
                     TGPYGQTFGDWLRDCGAKVIDLAVPYHAAVTPEEVERALADRPEIDFVSLVHAEAATGN
                     TNPVAAIGEVVRRHGALFMLDAVASVAAEPLLPDAWGVDLCVIGAQKAMGGPAGVSAVS
                     VSERAWARMAANPQAPRRSYLSLLDWKERWIDAGRRALLHAPAQLEMLALEACVERIES
                     VGPDIVMARHAAAARATRAGATALGIGLEPYVTEARDAAPV"
     misc_feature    2576..2590
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.48"
                     /tool="antismash"
     misc_feature    complement(2577..2592)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.97"
                     /tool="antismash"
     misc_feature    2696..2711
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.03"
                     /tool="antismash"
     misc_feature    2786..2802
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 20.13"
                     /tool="antismash"
     misc_feature    2843..2857
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.38"
                     /tool="antismash"
     gene            2866..3420
                     /gene="ectA"
                     /locus_tag="AB852_RS20660"
                     /old_locus_tag="AB852_20320"
     CDS             2866..3420
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010987798.1"
                     /locus_tag="AB852_RS20660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_20320"
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_073790701.1"
                     /transl_table=11
                     /translation="MTAAQADLRTQFREMPDGLRIDRPTVADGGALWRIARDSRTLDLN
                     SSYSYLLWCRDFAGTSVVARDADGQPVGFITGYIRPTRPGTLVVWQVAVDTAHRGRGLA
                     AALLDGLTERVTADRASAPVALNSLETTITPGNTASERLFLSYAERHGLAVDREVLFGA
                     GVFPDGGHDPEILYRIGPFAG"
     gene            3509..4780
                     /gene="ectB"
                     /locus_tag="AB852_RS20665"
                     /old_locus_tag="AB852_20325"
     CDS             3509..4780
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0045303 - diaminobutyrate-2-oxoglutarate
                     transaminase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (28-366). E-value: 1.5e-74.
                     Score: 242.9. Matches aSDomain:
                     nrpspksdomains_AB852_RS20665_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007448159.1"
                     /locus_tag="AB852_RS20665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_20325"
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_073790704.1"
                     /sec_met_domain="Aminotran_3 (E-value: 1.3e-79, bitscore:
                     262.6, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTITQPDLSVFETLESEVRSYCRSWPTVFDRAQGSRMYDEDGHEY
                     LDFFAGAGSLNYGHNNPVLKRALIDYLERDGVTHGLDMSTTAKRAFLESFQNLVLRPRD
                     LPYKVMFPGPTGTNAVESALKLARKVKGRESIVSFTNAFHGMSLGSLAVTGNAFKRAGA
                     GIPLVHGTPMPFDHYLDGQVQDFLWFERLLGDQGSGLNQPAAVIVETVQGEGGINVARA
                     EWLRALADLCARRDMLLIVDDIQMGCGRTGAFFSFEEAGIVPDIVTVSKSISGYGLPMS
                     LCLFKPELDIWEPGEHNGTFRGNNPAFVTAAAALEAYWSDGPAMEKQTLSRGQQVQEAL
                     GALAEEHREEIKEFRGRGLVWGVEFHDKGRASRVARRAFELGLLIETSGPEGEVVKLLP
                     ALTVSPDELEEGLRTLTRAVRETA"
     aSDomain        3593..4606
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AB852_RS20665_Aminotran_3.1"
                     /evalue="1.50E-74"
                     /label="AB852_RS20665_Aminotran_3.1"
                     /locus_tag="AB852_RS20665"
                     /protein_end="366"
                     /protein_start="28"
                     /score="242.9"
                     /tool="antismash"
                     /translation="FDRAQGSRMYDEDGHEYLDFFAGAGSLNYGHNNPVLKRALIDYLE
                     RDGVTHGLDMSTTAKRAFLESFQNLVLRPRDLPYKVMFPGPTGTNAVESALKLARKVKG
                     RESIVSFTNAFHGMSLGSLAVTGNAFKRAGAGIPLVHGTPMPFDHYLDGQVQDFLWFER
                     LLGDQGSGLNQPAAVIVETVQGEGGINVARAEWLRALADLCARRDMLLIVDDIQMGCGR
                     TGAFFSFEEAGIVPDIVTVSKSISGYGLPMSLCLFKPELDIWEPGEHNGTFRGNNPAFV
                     TAAAALEAYWSDGPAMEKQTLSRGQQVQEALGALAEEHREEIKEFRGRGLVWGVEFH"
     gene            5001..5399
                     /locus_tag="AB852_RS20670"
                     /old_locus_tag="AB852_20330"
     CDS             5001..5399
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006123624.1"
                     /locus_tag="AB852_RS20670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_20330"
                     /product="ectoine synthase"
                     /protein_id="WP_073790707.1"
                     /sec_met_domain="ectoine_synt (E-value: 6.5e-55, bitscore:
                     179.2, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSLKDIEGTDRHVKSRSGTWESKRIVLAKERVGFSLHETVLY
                     AGTETSMWYANHIEAVLCVEGEAELTDDETGEKHWISPGTMYLLDGHERHTLRPKTDFR
                     CVCVFNPPVTGREDHDENGVYPLLTEEV"
     gene            5403..6302
                     /gene="thpD"
                     /locus_tag="AB852_RS20675"
                     /old_locus_tag="AB852_20335"
     CDS             5403..6302
                     /EC_number="1.14.11.55"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019329311.1"
                     /locus_tag="AB852_RS20675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_20335"
                     /product="ectoine hydroxylase"
                     /protein_id="WP_073790710.1"
                     /sec_met_domain="PhyH (E-value: 3.9e-38, bitscore: 126.6,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATTTDIRADLYPSRGATEVSVPRKDPVVWNSPDAPGPVAREDLA
                     SFERDGFLTVDQLITPDEVTGYRAELDRLVGDPAIRADPRSIVESSSQEIRSVFEVHRI
                     SEVFAALVRDERVVGRARQILGSDVYVHQSRINVKPGFGASGFYWHSDFETWHAEDGLP
                     NMRTVSVSIALTDNLDTNGGLMIMPGSHRTFLGCAGATPKDNYKRSLQMQDAGIPSNGA
                     LTQFADEHGIRLFTGAAGSATWFDCNCMHGSGDNITPYARSNVFIVFNSVENTAQEPFA
                     APVRRPEYIGARDFTPVR"
     gene            complement(6397..7479)
                     /locus_tag="AB852_RS20680"
                     /old_locus_tag="AB852_20340"
     CDS             complement(6397..7479)
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016643609.1"
                     /locus_tag="AB852_RS20680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_20340"
                     /product="alkene reductase"
                     /protein_id="WP_073790713.1"
                     /transl_table=11
                     /translation="MTTAFDPIDLAGTRLANRVAMAPMTRSRAGAAGVPTALTAEYYAQ
                     RATAGLIITEGVQPSAVGQGYPDTPGLHSPEQTAAWRAVTDAVHARGGRIFAQLMHTGR
                     IGHPSLLPDGLVNVGASPVAAQGEVYTAEGAKAFVTPRELTDTEVHATVADFASAARNA
                     VDAGFDGVELHGANGYLIHQFLAAGSNVRTDAWGGSPVARARFAVAVTEAVAAEIGAAR
                     TALRISPGNGFNDISEPDPEPVYTELVRRLEPLGIAYLHLSEGSARIRELTHTLRKLFS
                     GVLILNPPSPDDADGTDHRALALVEDGTADMVAFGTLFLANPDLPARLRTAGPYNPPHR
                     PSFYGGDARGYTDYPTLDGS"
     gene            7794..8330
                     /locus_tag="AB852_RS20685"
                     /old_locus_tag="AB852_20345"
     CDS             7794..8330
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1284:
                     transcriptional regulator, MarR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014156956.1"
                     /locus_tag="AB852_RS20685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_20345"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_073790728.1"
                     /transl_table=11
                     /translation="MTASSGPAPSDPDCPPAARGGPVSNTLARVARLHRVTARELLRDL
                     DLYPGQEFLMMHLWSSGPVRPSELIKVLDLDPSTVTRMLQRLEQAGHVRRGQDPCDRRA
                     VLVEATEPSCALHDRMAAAWCELETRTLGGLDPAERRELARLLEKVEANLCGQAPRERG
                     DDPPGAPPREEHGGP"
     gene            complement(8478..9524)
                     /locus_tag="AB852_RS20690"
                     /old_locus_tag="AB852_20350"
     CDS             complement(8478..9524)
                     /NRPS_PKS="Domain: Aminotran_5 (17-304). E-value: 3.5e-25.
                     Score: 80.6. Matches aSDomain:
                     nrpspksdomains_AB852_RS20690_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005477739.1"
                     /locus_tag="AB852_RS20690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_20350"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_073791600.1"
                     /sec_met_domain="Aminotran_5 (E-value: 4.2e-20, bitscore:
                     66.8, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METLAVTAIRTEFTPEATYLNTASTGLLPARSVTAMREAVDATAA
                     GRPADMFEDLEASRASFARLVGVPASRVAAGASVAVYTGLVAASLAPGTEVLTAEGDFS
                     SLVTPFRVRQDLKVREVPLERIADAVRPTTGLVAVSAVQSADGRIADLPRVREAALAHG
                     ARTYVDASQSAGWLPIDADAYDYVVSVAFKWLLCPRGVTFLAVPEDFGGLSPVFAGWVS
                     GERPWDSCYGPVQELARSARRFDESPSLFSYVGARHSLALVESVGVDAIRAHDVALADR
                     FRAGLDALGHTPVPSPGSAIVSVPGLGARQREFSDGGIEVSDRAGNLRAAFHVHNTEGD
                     VDRLLSAL"
     aSDomain        complement(8613..9473)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AB852_RS20690_Aminotran_5.1"
                     /evalue="3.50E-25"
                     /label="AB852_RS20690_Aminotran_5.1"
                     /locus_tag="AB852_RS20690"
                     /protein_end="304"
                     /protein_start="17"
                     /score="80.6"
                     /tool="antismash"
                     /translation="TYLNTASTGLLPARSVTAMREAVDATAAGRPADMFEDLEASRASF
                     ARLVGVPASRVAAGASVAVYTGLVAASLAPGTEVLTAEGDFSSLVTPFRVRQDLKVREV
                     PLERIADAVRPTTGLVAVSAVQSADGRIADLPRVREAALAHGARTYVDASQSAGWLPID
                     ADAYDYVVSVAFKWLLCPRGVTFLAVPEDFGGLSPVFAGWVSGERPWDSCYGPVQELAR
                     SARRFDESPSLFSYVGARHSLALVESVGVDAIRAHDVALADRFRAGLDALGHTPVPSPG
                     SAIVSV"
     misc_feature    complement(9616..9631)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.23"
                     /tool="antismash"
     misc_feature    complement(9923..9938)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.58"
                     /tool="antismash"
ORIGIN
        1 acccgtgggg tgcgggagac ggacccgggg agggtgggtc aggccggtgc cggtgcggtt
       61 tcgggcagcc cggaccggcc ccggaccgcc ggggtgacgc ttcgtcaaca gcgtgcgcgc
      121 ccgggggcga tgatcggctc agccgacgat ccggccgcgg agcaccaccc gtcgcggagc
      181 cgcgaggacc cggacatccg cccgggggtc cgtctcgtac acgaccagat ccgccggggc
      241 gccctcggtg aggccggggc ggccgagcca ccgccgggcg ccccaggtgg tggcggacag
      301 ggcctcgacg ggcgggatgc ccgcggtgac gagttcggcg acctcgtccg cgaccagtcc
      361 atgggggagc gagccgcccg cgtccgtccc gacgaagacg ggcacccccg cgtcgtaggc
      421 ggcgcgcacg gtgtcgtacc gccgggcgtg gagccgtcgc atatgcgcgg accagcgggg
      481 gaacttgctc tcgccgccgt cggcgagccg ggggaacgtg gcgatgttga ccagggtggg
      541 gacgatggcg acgccgcgtt ccgcgaacag cgggacggtg tcctcggtga gtccggtggc
      601 gtgctcgacg cagtcgatac cggcctccac cagatcgcgc agcgcgtcct cggcgaagca
      661 gtgcgcggtg acccgggcgc ccagccggtg ggcctcggcg atcgcggccc ggacggcgtc
      721 ccggggccag caggccgtga ggtcacccgc gtcgcggtcg atccagtcgc cgacgagttt
      781 gacccagccg tcgccgcggc gggcctcctg ggcgacgtac gcgacgaggt ccgcgggctc
      841 gatctcatgg gcgtagttgc ggatgtagcg gcgggtgcgg gcgatatggc ggcccgcgcg
      901 gatgatcctc ggcaggtcct cgcggtcgtc gatccagcgg gtgtcggagg gggagcccgc
      961 gtcgcggatc agcagggccc cggcctcgcg gtcggtgagg gcctgcttct cagcggtcgc
     1021 ggcggggacg ggcccgtggg cgtccagtcc cacatggcag tgcgcgtcca ccagaccggg
     1081 cagcgcccac ccccgtacgg tgacggtgtc ccggacgccg gccggccgct cgtaggtgat
     1141 ccgccccccg accacccaca gttcgtcccg tacgtcgtcg ggtcccacca gcacccgtcc
     1201 gctcacgtgc agcaccgtgc gatcgctcat gtcccgcaac ctacccctcg cccgcgcggg
     1261 cccggcaggc tcctgtcccg cccccggcga cctgcggtta cgctcatgtc gttccgtgag
     1321 ccgtccacgg cttcccgtac cgaggagagc agcgccgtga gccatcccct actcgacctg
     1381 gcgcccctga ccgccgaccg tttcgccgcg atcgagcggc gggtggcggg tctgctggcc
     1441 accgagcagg acgtcgtgat cacccagggc gaggccctgc tcccgctgga gggctgtatc
     1501 cggggggcgg ccggtccggg cacgaccgcg ctgaacgtca tcaccggccc gtacgggcag
     1561 accttcgggg actggctgcg ggactgcggc gcgaaggtga tcgacctcgc ggtgccgtac
     1621 cacgcggcgg tgacgcccga ggaggtcgag cgggcgctgg cggaccgtcc ggagatcgac
     1681 ttcgtgtcgc tcgtgcacgc cgaggccgcc accggcaaca ccaacccggt cgccgcgatc
     1741 ggtgaggtcg tccggcggca cggcgcgctg ttcatgctgg acgcggtggc ctccgtggcc
     1801 gcggaaccac tgctgccgga cgcgtggggc gtggacctgt gcgtgatcgg cgcgcagaag
     1861 gcgatgggcg gtccggccgg ggtgtcggcg gtgtcggtga gcgagcgggc gtgggcgcgg
     1921 atggccgcga acccgcaggc gccgcggcgt tcgtatctgt cgctgctgga ctggaaggag
     1981 cggtggatcg acgcggggcg ccgggcgctg ctgcacgcgc ccgcgcagtt ggagatgctg
     2041 gcgctggagg cgtgcgtcga gcggatcgag tcggtcgggc cggacatcgt gatggcgcgc
     2101 cacgcggcgg cggcacgggc cacccgggcg ggggcgacgg ccctcggcat cgggctggag
     2161 ccgtatgtca ccgaggcgcg ggacgcggct ccggtggcga cgacgctgcg ggtcccggcg
     2221 gacgcggacg cgtccgcggt ggtggcgcgg gcgctcgcgc tcgacccggg gctgccactg
     2281 gtggccgggg gcggggcgct ggcgcgggag atggtgcggg tcaaccacta cggcccggac
     2341 gcgacggacg aagtggtcga gcgctcgctg gcggcgctgg ccggggcgct gtcgggctga
     2401 gcccctgggc gggccggggc ggcggccgac gggcatccgc cgggcgagcg ccggagggcc
     2461 accacgtccg cccggcaggt ctgtccggcg ggggcgccga gcgggtccgt acgggcctcc
     2521 tggaatcgtg gacgtaattc acggggccgg ggttgcctgt acgggcatta atattcgaaa
     2581 ttagttttcg ctcaggcgcc catattctcc tgcccgctta tccaaaccct aaacgctaag
     2641 gtttcgtgaa cgcacggcgg cgcaattgcg gcaggttccg ccaggtcgac gatcctgtga
     2701 tccattccac atcaagcccg tttcgtacca taaatccagt acgaaacggg ctttttgctg
     2761 ccttctcgcg cgtccgcatg cgcccgcgtg ataacataac gacgccctgg aagtaacccc
     2821 accgggccat gcaatccaag gaattgctcg gtaaattaaa tccgcatgac cgctgcacaa
     2881 gcagacctgc gaacgcaatt ccgagaaatg cccgacggac tacggataga ccgtccgacg
     2941 gtggccgacg gcggtgcgct ctggcgcatc gcacgggact cccggaccct cgatctgaac
     3001 tcctcctaca gctatctcct gtggtgccgc gacttcgcgg gcacctccgt ggtggcacgt
     3061 gacgcggacg ggcagccggt cggcttcatc accggataca tccggcccac ccgtccgggc
     3121 acgctcgtcg tctggcaggt cgccgtcgac acggcgcacc ggggccgggg actcgccgcg
     3181 gcgctgctgg acgggctcac cgagcgggtc accgccgacc gggcgtccgc gcccgtcgcg
     3241 ctgaactcgc tggagaccac catcacgccc ggcaacacgg cctccgagcg gctgttcctc
     3301 tcgtacgccg aacggcacgg gctggccgtc gaccgggagg tgctcttcgg cgccggggtg
     3361 ttccccgacg gcgggcacga ccccgagatc ctctaccgca tcggcccgtt cgccggctga
     3421 ccggcgccgg acccgtacca ccggcgcccg tcccgctcac gccgacccgc cccaccacct
     3481 gtcaccccga acagccagga gacctgccgt gaccatcacc cagcccgacc tgagcgtctt
     3541 cgagaccctg gagtcggagg tgcgcagcta ctgccgcagc tggcccaccg tcttcgaccg
     3601 tgcccagggc agccgtatgt acgacgagga cggccatgag tacctcgact tcttcgcggg
     3661 ggccgggtcg ctcaactacg gccacaacaa ccccgtactc aaacgcgccc tgatcgacta
     3721 cctggagcgc gacggggtca cccacggtct cgatatgtcg acgacggcga agcgggcgtt
     3781 cctggagtcg ttccagaacc tggtgctgcg tccccgtgac ctgccctaca aggtgatgtt
     3841 cccgggtccg accggcacca acgccgtgga gtccgcgctg aagctggccc gcaaggtgaa
     3901 gggccgcgag tcgatcgtgt cgttcaccaa cgcgttccac gggatgtcgc tgggctcgct
     3961 ggcggtcacg ggcaacgcct tcaagcgggc gggcgcgggc atcccgctgg tgcacggcac
     4021 cccgatgccg ttcgaccact acctggacgg ccaggtgcag gacttcctct ggttcgagcg
     4081 gctgctcggg gaccagggct ccgggctcaa ccagccggcc gcggtgatcg tggagaccgt
     4141 gcagggcgag ggcggcatca atgtggcgcg cgccgagtgg ctgcgggcgc tggcggatct
     4201 gtgcgcgcgg cgggacatgc tgctgatcgt ggacgacatc cagatgggct gcgggcgcac
     4261 cggcgcgttc ttctccttcg aggaggcggg catcgtgccg gacatcgtga cggtctccaa
     4321 gtcgatcagc ggctacgggc tgccgatgtc gctgtgcctg ttcaagccgg agctggacat
     4381 ctgggagccc ggcgagcaca acggcacctt ccgcggcaac aacccggcgt tcgtgacggc
     4441 cgcggcggcc ctggaggcgt actggtcgga cgggcccgcg atggagaagc agaccctgtc
     4501 gcgcgggcag caggtccagg aggcgctggg cgcgctggcc gaggagcacc gcgaggagat
     4561 caaggagttc cggggccgcg gactggtgtg gggtgtggag ttccacgaca aggggcgggc
     4621 ctcccgggtg gcgcggcgcg ccttcgagct ggggctgctg atcgagacct cgggccccga
     4681 gggcgaggtc gtcaagctgc ttcccgcgct gaccgtctcc cccgacgagc tggaggaggg
     4741 cctgcgcacc ctcacccgcg cggtccgcga gaccgcctga cccggacccg gacccggacc
     4801 ctgatccggc cccgaacccg gccctgaacc ggaccaggcc ccacgccggt cccggtcccg
     4861 atacccgacc cccctacctg atccatgtcc cggcgccgtc ccggccggtc ccgggcagcg
     4921 tccgtccgcc ggggacaccc gtccgtccgg cgtcatccgt ccggcgccgt ccgtccgcca
     4981 gagaaaggca gcacgtcacc gtgatcgtcc gatcgttgaa ggacatcgag ggaaccgacc
     5041 gtcatgtgaa gtcacgctcg ggcacctggg agagcaaacg catcgtcctc gccaaggagc
     5101 gggtcggctt ctcgctgcac gagaccgtgc tgtacgcggg tacggagacc tccatgtggt
     5161 acgccaacca catcgaggcc gtgctgtgcg tcgagggcga ggccgagctg accgacgacg
     5221 agaccggcga gaagcactgg atcagcccgg ggacgatgta tctgctggac gggcacgagc
     5281 ggcacaccct gcggccgaag accgacttcc ggtgcgtgtg cgtgttcaac ccgcccgtca
     5341 cgggccgtga ggaccacgat gagaacggcg tatatccgct tctgaccgag gaggtatgaa
     5401 cgatggccac cacgaccgac atccgcgcgg acctgtatcc gagccggggc gccaccgagg
     5461 tgtccgtgcc gcgcaaggac ccggtcgtct ggaactcccc ggacgccccg ggccccgtcg
     5521 cgcgcgagga cctggcctcg ttcgagcggg acggcttcct gaccgtggac cagctgatca
     5581 cgcccgacga ggtgaccggc taccgcgccg aactcgaccg gctggtcggc gacccggcga
     5641 tccgcgccga cccccggtcg atcgtggagt cgtcctccca ggagatccgc tcggtcttcg
     5701 aggtgcaccg gatcagtgag gtgttcgccg cgctggtgcg cgacgagcgg gtggtgggcc
     5761 gcgcccggca gatcctcggc tcggacgtgt acgtccatca gtcccggatc aatgtgaagc
     5821 cggggttcgg ggcgtccggg ttctactggc actcggactt cgagacctgg cacgccgagg
     5881 acggactgcc gaacatgcgg acggtgtccg tgtcgatcgc gctgaccgac aacctcgaca
     5941 ccaacggcgg tctgatgatc atgccgggct cgcaccggac gttcctgggc tgcgcgggag
     6001 cgaccccgaa ggacaactac aagcggtcgc tccagatgca ggacgcgggc atcccgtcga
     6061 acggggcgct cacacagttc gcggacgagc acggcatccg gctgttcacg ggtgcggcgg
     6121 ggtcggccac ctggttcgac tgcaactgca tgcacggctc gggcgacaac atcaccccgt
     6181 acgcgcgcag caatgtcttc atcgtcttca acagcgtgga gaacacggcg caggagccct
     6241 tcgccgcgcc ggtccgcagg ccggagtaca tcggggcacg ggacttcacc cccgtgcgct
     6301 gagcaccacg gtggtacggc ggggcggtga ccggaacctt ccggtcaccg ccccgccgcg
     6361 cgttcccgtg gcacgtggag gcggggcggc gcttcgtcag cttccgtcga gcgtcgggta
     6421 gtcggtgtat ccacgggcgt cgccgccgta gaagctgggg cggtgcgggg ggttgtacgg
     6481 accggcggtc cgcagccgcg ccgggaggtc cgggttcgcg aggaacagtg tgccgaaggc
     6541 gaccatgtcg gcggtaccgt cctcgacgag ggcgagcgcc cggtgatcgg tgccgtccgc
     6601 gtcgtcgggc gagggcggat tgaggatcag tacgcccgag aagagcttgc gcagggtgtg
     6661 ggtcagttca cgtatccgcg cggagccctc ggagagatgc agataggcga tcccgagcgg
     6721 ctccagccgc cgcaccagtt cggtgtacac gggctccggg tccggctcgc tgatgtcgtt
     6781 gaacccgttt ccgggcgaga tacgcagcgc ggtgcgcgcg gcgccgatct ccgccgccac
     6841 cgcctcggtc accgcgacgg cgaaccgggc gcgggccacg ggcgaaccgc cccacgcgtc
     6901 ggtgcggaca ttggaccctg ccgcgaggaa ctggtggatc agatagccgt tggcgccgtg
     6961 cagctcgacc ccgtcgaacc cggcgtccac cgcgttgcgg gcggccgacg cgaagtccgc
     7021 gacggtcgcg tggacctcgg tgtccgtcag ctcccggggg gtgacgaagg ccttggcgcc
     7081 ctcggcggtg tacacctcgc cctgggcggc cacgggggac gccccgacgt tcaccagccc
     7141 gtccggcagc aggctggggt gcccgatccg gcccgtgtgc atcagctggg cgaagatccg
     7201 gccgccgcgc gcgtgcaccg cgtcggtgac cgcgcgccag gcggcggtct gctccgggct
     7261 gtgcagaccc ggtgtgtccg gatagccctg tcccaccgcg ctgggctgga cgccctcggt
     7321 gatgatcaga ccggcggtcg cccgctgggc gtagtactcg gccgtcagcg cggtgggcac
     7381 tccggcggca ccggcgcggc tgcgggtcat cggcgccatc gcgacgcggt tggcgagccg
     7441 ggtcccggcg aggtcgatcg ggtcgaacgc tgtcgtcatg gtgactgctc cccagcacgg
     7501 tgatcggtac gaaggtcggg cggtgcgaaa gtctggcggt gcgatggttg gccggcgcac
     7561 tggtcggccg gcgctccagg tggtcggcgc gatggccggc cggggcgata gttggtcggc
     7621 caagcaagag aaccgcgcgc cactgtagct cattccttgg ccggccaagg taatctggcg
     7681 gaccaacccc ccacgcacgt aacgcggttc ggcggcggcc ccgccaccac cggccccccg
     7741 gcagccggac cccccgctgc cccggtccgc cccgcccacc caggagcctc cccatgaccg
     7801 cttcctccgg ccccgccccg tccgaccccg actgtccccc ggcggcccgg ggcggccccg
     7861 tcagcaacac cctggcccgg gtggcgcggc tgcaccgcgt caccgcccgc gagctgctgc
     7921 gggacctgga cctgtacccg ggccaggagt tcctgatgat gcatctgtgg agctccgggc
     7981 cggtgcgccc gtccgagctg atcaaggtgc tggacctgga cccctcgacg gtgaccagga
     8041 tgctccagcg gctggagcag gcgggccatg tccggcgcgg acaggacccc tgcgaccggc
     8101 gcgcggtcct ggtggaggcg accgagccga gctgcgcgct gcacgaccgg atggcggcgg
     8161 cctggtgcga actggagacc cggaccctcg gcggtctcga ccccgcggag cgccgggagc
     8221 tggcccggct gctggagaag gtcgaggcga acctgtgcgg gcaggccccc cgggagcgcg
     8281 gggacgaccc gcccggggca ccgccgcgcg aggagcacgg cgggccgtga gcgggcgtac
     8341 gggggcgggc gtacgggcgg gggcggagcg tacggcggtc cgggcggctc gccttacggg
     8401 tcccggggcc cgttcccggt cctgttcccg gtcccgctgc cgggtcccgc tcccgggtcc
     8461 cgcgtggccc cgggttccta cagggcgctc aggagccggt cgacgtcccc ttccgtgttg
     8521 tggacgtgga acgccgcgcg cagattgccc gcgcggtccg agacctcgat cccgccgtcg
     8581 ctgaactccc gctggcgggc cccgagcccg gggaccgaga cgatcgcgga gccgggggac
     8641 ggcaccgggg tgtgcccgag ggcgtccaga cccgcgcgga agcggtcggc cagggccacg
     8701 tcatgggcgc ggatcgcgtc cacgcccacg ctctcgacca gggccaggga gtgccgcgcc
     8761 cccacgtacg agaagaggct cgggctctcg tcgaaccggc gggccgagcg tgccagctcc
     8821 tggaccgggc cgtagcagct gtcccagggc cgctcccccg acacccagcc cgcgaacacg
     8881 gggctcagcc cgccgaagtc ctcggggacg gcgaggaacg tgacaccgcg cgggcacagc
     8941 agccacttga acgcgacgga caccacgtag tcgtacgcgt cggcgtcgat cggcagccac
     9001 ccggcggact gcgacgcgtc gacataggta cgggcgccgt gggcgagggc ggcctcccgg
     9061 acacggggca gatcggcgat ccgtccgtcg gcggactgga cggcgctcac cgcgaccaga
     9121 ccggtcgtgg ggcgcaccgc gtccgcgatc cgctccagcg gcacctcgcg caccttcagg
     9181 tcctggcgga cacggaaggg ggtgaccagc gagctgaagt ccccttcggc ggtgagcacc
     9241 tccgtgcccg gcgccaggga agcggcgacc agcccggtgt acacggcgac ggacgccccc
     9301 gccgcgaccc gggacgccgg gacgccgacg agccgcgcga aactcgcgcg gctcgcctcc
     9361 agatcctcga acatatcggc cggccgcccc gcggccgtgg catccaccgc ctcccgcatc
     9421 gcggtgacgg atctggcggg gagcagcccg gtgctggcgg tgttcagata ggtcgcctcg
     9481 ggagtgaact cggtacggat cgcggtaacg gcaagtgtct ccatggcctc actgtgccgc
     9541 cccgccgcgc cccggtccat gacgcctccc ggtgtatccg gccggggacg cccccgcgcc
     9601 cgcctttgaa ctgcggaaac gcgggcgtga ccggtggcgg gttcgcgcct gcgcaagctc
     9661 aggcgcggct ggtggccggg ttcacgcccg tggaacctca ggcccgatag agcccaggcc
     9721 cgtggaagct caggcgcccg tggcagctca ggcccgctcg gcggcctggt tcgcgtcctg
     9781 cggtatctcg cagccgtcgg gcccgcacgc ctcggcgtcg gtgtccgcgc cggccgggac
     9841 gatcggggtg agcggggagc gggcgcccca cgcctggtcg agggcctggg cgaagacctc
     9901 ggcgggctgg gccccggaca caccgaaccg gcggtcgagg acgaagaagg ggacgccgtt
     9961 cgcgcccagc tcggcggcct cgcgttcgtc ggcgcggacc gcgtcggcgt agcgctccgg
    10021 gtccgcgagg accgcgcggg cggcgtccgc gtccaggccc gcctcggcgg cgagggccac
    10081 cagccggtcc tcggcggcgc cgtagacgga ctcctcctcg gcgaagttcg cccggtagaa
    10141 cagaccgatc agcgtgtcct gcctgccgtg ctccttggcg aagtgcagca gccggtgcat
    10201 gtcgaaggtg ttgccgtggt cacgtccctc ggtgcggtac gccagtccct cggccgccgc
    10261 gttccgcccg aggtcgagtt cggccgcccg cgcctgctcc tcggtcatgc cgtacttctt
    10321 gctgagcatc ggcaggacca gcgacacctc gtccttggac cgtcccgggt ccagctcgaa
    10381 ggagcggtgg accacctct
//
