LOCUS       NZ_LFBV01000002        25295 bp    DNA     linear   CON 03-MAY-2024
DEFINITION  Streptomyces uncialis strain DCA2648 scaffold2, whole genome shotgun
            sequence.
ACCESSION   NZ_LFBV01000002
VERSION     NZ_LFBV01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces uncialis
  ORGANISM  Streptomyces uncialis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 1356271)
  AUTHORS   Yan,X., Huang,T., Ge,H. and Shen,B.
  TITLE     Cloning and characterization of the uncialamcin biosynthetic gene
            cluster
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1356271)
  AUTHORS   Yan,X., Huang,T., Ge,H. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-JUN-2015) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33410, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 19-MAY-2015
            Assembly Method                   :: CLC Genomics Workbench v. 8.0.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905345.1-RS_2024_05_03
            Annotation Date                   :: 05/03/2024 03:03:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,456
            CDSs (total)                      :: 7,371
            Genes (coding)                    :: 7,214
            CDSs (with protein)               :: 7,214
            Genes (RNA)                       :: 85
            rRNAs                             :: 6, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1 (5S, 16S)
            partial rRNAs                     :: 5 (23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 157
            CDSs (without protein)            :: 157
            Pseudo Genes (ambiguous residues) :: 0 of 157
            Pseudo Genes (frameshifted)       :: 42 of 157
            Pseudo Genes (incomplete)         :: 143 of 157
            Pseudo Genes (internal stop)      :: 7 of 157
            Pseudo Genes (multiple problems)  :: 33 of 157
            CRISPR Arrays                     :: 14
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:56:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 137407
            Orig. end                         :: 162702
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LFBV01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25295
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="melanin"
                     /product="CDPS"
                     /region_number="2"
                     /rules="melC"
                     /rules="CDPS"
                     /tool="antismash"
     cand_cluster    1..25295
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /detection_rules="CDPS"
                     /kind="neighbouring"
                     /product="melanin"
                     /product="CDPS"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..10453
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10453
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5453](+)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5453
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     gene            35..901
                     /locus_tag="AB852_RS08990"
                     /old_locus_tag="AB852_08805"
     CDS             35..901
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016208 - AMP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016827226.1"
                     /locus_tag="AB852_RS08990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_08805"
                     /product="universal stress protein"
                     /protein_id="WP_073785859.1"
                     /transl_table=11
                     /translation="MPRTVIAGVDGSRESLSAVEWAAGEASRRGLPLRLLHVRDTSPGV
                     RAFFAGAGRALWPDGGPQAAIEGLQARHPGLEVTTDDIPGRPAETLCTAKDQELLVLGS
                     RGLGRLAGFLLGSASLAVIARSTAPVVLVRAKDTSSAQEWQSSGDVVVGLDTSHRSDAV
                     LEFGFAHAERHSLALRALHSWQVPQVYGGDPTGAMLSAQTDLATVTSEVLTEILAPWRE
                     KFPTVAVTERCRLGHPAHDLVEASRDAGLLVVGRRERRVGVGAHIGSVAHAVLHHSKAA
                     VAVVPHA"
     misc_feature    50..64
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.51"
                     /tool="antismash"
     gene            complement(1401..3122)
                     /locus_tag="AB852_RS08995"
                     /old_locus_tag="AB852_08810"
     CDS             complement(1401..3122)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004979371.1"
                     /locus_tag="AB852_RS08995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_08810"
                     /product="GAF domain-containing sensor histidine kinase"
                     /protein_id="WP_073785861.1"
                     /transl_table=11
                     /translation="MTHAQDSGARPAQGGRQECDEQLALLQGRLDAAHSTRDRVQDLME
                     VVMSVGRDLELEHVLRHVVKAATALVRARYGALGVIGPDHEKLVQFLTVGVDDAEAAVI
                     GSSPSGHGILGELVAHPEPLRLAKLSEHASSYGFPAGHPPMSTFLGVPIRIRGQVFGNL
                     YLTEKLGGAQFDAEDESILTTLAVAAGVAIDNARLYERSQQRELWLQATAEVTQSLLSG
                     SERAVVLALIADRAREIAGADLVVVALPAADRDSLVVELADGLEADRYRALRLAVSSGL
                     IGTAFTRAVPVTSEDMDDPGPAAYLGGPTGLGPGVAIPIGTGAGVRGVLLLVRASGRAP
                     FLAEEIRPVLGFAGTAAVAMELAERRSDTEQIVLLEERDRIARDLHDLAIQRLFATGMT
                     LQSAGRFIDHPEASERVERAVDDLDATIKIIRSTIFGLRTQVEGEGERLRARTVRAVAV
                     AAASLGFSPGLRKEGLLDTQVSRFVADHLLAVLGESLANVVRHARASRVEVTLRTNGRE
                     VTLTVADDGVGIEGSGRHSGLRNLSDRAERCGGTMELSSPPGGGTRLVWRVPAAGP"
     gene            complement(3226..3987)
                     /locus_tag="AB852_RS09000"
                     /old_locus_tag="AB852_08815"
     CDS             complement(3226..3987)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018383329.1"
                     /locus_tag="AB852_RS09000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_08815"
                     /product="response regulator transcription factor"
                     /protein_id="WP_079184445.1"
                     /transl_table=11
                     /translation="MPDSGSRGPENPIRVFLLDDHEVVRRGVRDLLGDEPDISVVGEAG
                     TAEQALTRVPALRPDVAVLDVRLPDGNGVDVCRELRSRMPDLACLMLTSFDDEEALLDA
                     VMAGASGYVLKLIQGGDLVAAVRTVASGKSLLDPSAAARLMSRLRGEDRDESAADALYG
                     LTSRERDILALIGEGLTNREIGLRVFLAEKTVKNHISRVLAKLGVERRVQAAVIATQVS
                     GAAEGRPAAAARAGSDGSGRADPDRYRGPGR"
     misc_feature    3997..4011
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 18.38"
                     /tool="antismash"
     gene            4233..4706
                     /locus_tag="AB852_RS40610"
                     /old_locus_tag="AB852_08820"
     CDS             4233..4706
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018884.4"
                     /locus_tag="AB852_RS40610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_08820"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_073785863.1"
                     /transl_table=11
                     /translation="MGDVRGKGITAIETVPIVLGAFREASHDERTLPEVAARLEKTLDR
                     DRADRNGGHDLELRLTGRRFPTPARLLSTLVDDVQRFSGGLTATTWPSSPPTSRCPARH
                     AEAVASADRGRLRVVDVAGPYEVPAPAVLLPDGRLLEGTTLISRRRPAPRTVV"
     cand_cluster    4483..25295
                     /SMILES=""
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="CDPS"
                     /kind="single"
                     /product="CDPS"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    4483..25295
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="False"
                     /core_location="[14482:15295](-)"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(14483..15295)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="2"
     misc_feature    complement(4863..4879)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.96"
                     /tool="antismash"
     misc_feature    complement(4865..4879)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 18.05"
                     /tool="antismash"
     gene            5001..5453
                     /locus_tag="AB852_RS09010"
                     /old_locus_tag="AB852_08825"
     CDS             5001..5453
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0042438 - melanin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003966560.1"
                     /locus_tag="AB852_RS09010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_08825"
                     /product="tyrosinase family oxidase copper chaperone"
                     /protein_id="WP_073785865.1"
                     /sec_met_domain="melC (E-value: 1.1e-37, bitscore: 125.4,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKLTRRQAFGTVAGAAAGIAVAGIAVASANATPDKASRSTTAAT
                     GTAAGTKHHHTAVPAPFSEVFEGRRIQGIPGDANAKSEAHGQHHTSATGYRVLIDGREL
                     HVMQKPDSSWTSVMNHYQTFPDPHTTARAAVTSLMGADLVPHTPTA"
     gene            5470..6288
                     /locus_tag="AB852_RS09015"
                     /old_locus_tag="AB852_08830"
     CDS             5470..6288
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018960094.1"
                     /locus_tag="AB852_RS09015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_08830"
                     /product="tyrosinase family protein"
                     /protein_id="WP_073785867.1"
                     /transl_table=11
                     /translation="MTVRKNQANLTPAEKRAFVNAVVELKRRGRYDPFVTTHREIFISD
                     MTGPIRQGHESPSFLPWHRQYLIDFERALQSINPNVSIPYWDWTRDRTPTSSLWSANFL
                     GGNGRRPDGQVMNGPFAHSNGNWSITVQDDTAPFLRRAMAPTGMPLPTRAELNTVLAVT
                     PYDTTPWDFTAPGFRNSLEGGAGPGLHNRVHNWVGGQMLQSVSPNDPVFWLHHCFVDKI
                     WADWQRRHPQHSYLPAVSTTGVVALNQAMAPWNNVTPAAMLDHTRFYTYA"
     gene            complement(7136..7459)
                     /locus_tag="AB852_RS09020"
                     /old_locus_tag="AB852_08835"
     CDS             complement(7136..7459)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004938756.1"
                     /locus_tag="AB852_RS09020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_08835"
                     /product="beta/gamma crystallin domain-containing protein"
                     /protein_id="WP_073785869.1"
                     /transl_table=11
                     /translation="MAALAATALPASAASDRVSPLIHRVSCDRTDYLEVHGNNGQSVLC
                     FADRGFMGVAIYGINWIESGNNRAEIQFQRSVGNPRIESVTMGKWSAWNPGHVHKVTRI
                     EIF"
     misc_feature    complement(7833..7850)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 20.94"
                     /tool="antismash"
     gene            7886..8863
                     /locus_tag="AB852_RS09025"
                     /old_locus_tag="AB852_08840"
     CDS             7886..8863
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008742550.1"
                     /locus_tag="AB852_RS09025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_08840"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_079184447.1"
                     /transl_table=11
                     /translation="MAGTEAGADDSRGAFSLDTTTPGPLPRGFASFRREWETQVGDGFP
                     LPTFSPATTGDFRVEGRVAKVRDAAITDVNCASAIRTAALGDVEDQVRMWVVQRGAWTL
                     GGPGDEHTVSAGQFLLRHVGRPSHFATAPHTTAKIVVLPATMLKPLLGNQIVAGSLDSA
                     EVRLLVAHTNMIHANVTDLGPAGVRAAHSALIELAKAVAGHRFDDKEPLLASALAQAAK
                     DLADSRLTDPSLSSSMLASELSVSVRTLQRAFATGGEPVTAYIRRRRLEEARLALTAPF
                     GRLNISELAAHWQFADSSHFIRAFKTHYGQTPTDHAGRARSRKE"
     misc_feature    7958..7960
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    8519..8521
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    9102..9115
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.67"
                     /tool="antismash"
     gene            9219..9452
                     /locus_tag="AB852_RS09030"
                     /old_locus_tag="AB852_08845"
     CDS             9219..9452
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AB852_RS09030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AB852_08845"
                     /product="hypothetical protein"
                     /protein_id="WP_143201195.1"
                     /transl_table=11
                     /translation="MIEMLGLAVRSRYEWLRFEDVYATSAWASILVSAGVVEWFVVHRT
                     LKPLARRPRPRGTPAVTPGGATTIPRTGRIPA"
     gene            9635..10834
                     /locus_tag="AB852_RS09035"
                     /old_locus_tag="AB852_08850"
     CDS             9635..10834
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016471683.1"
                     /locus_tag="AB852_RS09035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_08850"
                     /product="AAA family ATPase"
                     /protein_id="WP_073787570.1"
                     /transl_table=11
                     /translation="MEAQDSQDTAKRLRAICNEVSDRFFERADVVRTLVMTLLAGQHSL
                     VLGPPGTAKSEMARELTGRVEGATYWEILLSKFTAPTRIFGPIDVAALARGEYRQVYEG
                     RATTAHIAFIDEIFKCSTAALNETLGFLNERLYHPENGGKPLSCPLIGAITASNELPIG
                     EDSAAIYDRLLVRIEVGYLADPSNFAALVRSAVNRPAPLTRTTVELSALQHAVAEAVPA
                     VDLPDVMVDAVCTLRAALRRKELIASDRRWRQAVGLLQASAFLDGRPAVTEADLAVLTH
                     VLWDSPTERPTVEREVLQLVNPDAKEALDLADVIEELEAQLEAMAGQSREALSEWVIKK
                     AHNKLATAGNRLAKLRKEAAGAGRSTAAIDRVTGRQRAVRARVLTEALGMDASMVQTQL
                     "
     gene            10854..12458
                     /locus_tag="AB852_RS09040"
                     /old_locus_tag="AB852_08855"
     CDS             10854..12458
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014044133.1"
                     /locus_tag="AB852_RS09040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_08855"
                     /product="VWA domain-containing protein"
                     /protein_id="WP_073785873.1"
                     /transl_table=11
                     /translation="MGRTPSRHNESSSRAGGKLSTSATAPERHRTTVVVDRFDQISWRD
                     TYEQSAGLSELAKELNERYGCGADLLADAFQAAYKVSARLRERAEMDRSRLVNHQIITA
                     LAESCEFAELRRVTVGDPYAAAMAVLAQAPALRRMLEHSRNAQEQAEQVEKAQQNAASD
                     ATTLCEALRRTAGSADEDTAVSASDAVQHSIKAATAAARQSDRSAAQALPAAAPGMGAT
                     ARSAAMKAVEIVRGEAALMRAWGIGPGELEKMPFDQRAQLAERLRTGRLAQWAELIGRF
                     RQMASGERARKVANATGELVGVTLGDDLSRVIPSELVNLGLPELRAVFAARYAAGELML
                     YHSQGEQATGQGAIIACVDTSHSMYLAGRDGVSREAWAKACALALLDQARHAKRDFVGI
                     LFSAADKIQVFRFPAGQPADPAQVLDFAETFLGGGTSYQTPLTAAGELLAEELNDAARG
                     RGDIVMITDDECGIAEEWMRGWNIAKHRLGFRVFGVAIGAPRATEADSVLDALCDNLRS
                     IEDLTDVSAAADLFRMI"
     gene            complement(13279..14502)
                     /locus_tag="AB852_RS09050"
                     /old_locus_tag="AB852_08860"
     CDS             complement(13279..14502)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.4"
                     /locus_tag="AB852_RS09050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_08860"
                     /product="cytochrome P450"
                     /protein_id="WP_073785875.1"
                     /sec_met_domain="p450 (E-value: 1.1e-22, bitscore: 76.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTIPDDLTWPDSFPTRGHGLPPEMFDLLRRERPVARVAFPSGHH
                     AWLVTRRADITAIGSSRSFSRDLTCPGGQRIAGDDFNSVPGGIFNLDPPAHTTVRRVVQ
                     PFFNPAAATALRPAVALAATDLATALRDGPNPADLHRAYAHPLAATLACDLMRVAPRQR
                     RKIVPRLRSQVDYTTPASAIDTSTRWMLDFADEVIDAKSADYDDNREPRDPVEALIRAH
                     RHGTITREQMHATVMYLFVTSAEPVTGPVTTGVYTLLRHGDQLARIQRDPTLWPDAVAE
                     LLRLHHNGMTSMPRLALTDTEMHGVLIRAGDAVITPWVAATWDPEHYKQPERFRLDRSA
                     QEDPAITFGTGPHFCLGVNIARMYLETALSTLFSHLPDLALAAKHEDIAWEPDTYLFTR
                     PVELPVTW"
     gene            complement(14483..15295)
                     /locus_tag="AB852_RS09055"
                     /old_locus_tag="AB852_08865"
     CDS             complement(14483..15295)
                     /GO_function="GO:0016755 - aminoacyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) CDPS:
                     CDPS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF028025.4"
                     /locus_tag="AB852_RS09055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_08865"
                     /product="tRNA-dependent cyclodipeptide synthase"
                     /protein_id="WP_178390972.1"
                     /sec_met_domain="CDPS (E-value: 2.6e-39, bitscore: 131.1,
                     seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQIQDTHAHVPGTGTGTGASTGTDLPPSPPQEPIAPSGFRVEGL
                     DLHDPRLAERYGTVVLGLSPFNSFYSTETVTALCRSASVSFDDVHVVLPGAPESALRHI
                     SAGKAPRRAVQRSKRVIHNMRNVARRTLADCGVPDTDSRVHVLTRFAAHPRYREVRTRI
                     ETAYRTQTPMREAVCAMTRTALEASIDSEPTPAQIEDNTRYIFAESPLLLDSTGVLARP
                     RALFVYHRRVPVYDVVADGQVPGLTIGSGHVLSVLTDERNDRDDHDSR"
     gene            complement(15371..16201)
                     /locus_tag="AB852_RS09060"
                     /old_locus_tag="AB852_08870"
     CDS             complement(15371..16201)
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (32-130). E-value: 2.3e-07. Score:
                     21.1. Matches aSDomain: nrpspksdomains_AB852_RS09060_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013382.4"
                     /locus_tag="AB852_RS09060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_08870"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_073785879.1"
                     /transl_table=11
                     /translation="MAMDSQFDTAVAAYERSMEEMPFREHIEEYSFLNAVGDVTGRDVL
                     DLGCGSGLYARRLRGAGAARVVGMDESAAMVEHARRREEREGLGVEYLAANATDPGATD
                     LPGIAGAFDVVTAVYVLPYAPTREALEGFCVTARRALRPTGGRFVAAVLNPGFSTDPQW
                     YRGYGMRLSVRQSPAEGTPGHLRAWVGQDVLDLDLFRWSAAAHEQALATAGFDRVSWIR
                     PTVSEEGLAKHGEAFWENYLTCPHSLIIDAQAGPGSEPADRPLPVENPAPTPAK"
     aSDomain        complement(15812..16105)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AB852_RS09060_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="2.30E-07"
                     /label="AB852_RS09060_oMT.1"
                     /locus_tag="AB852_RS09060"
                     /protein_end="130"
                     /protein_start="32"
                     /score="21.1"
                     /tool="antismash"
                     /translation="LNAVGDVTGRDVLDLGCGSGLYARRLRGAGAARVVGMDESAAMVE
                     HARRREEREGLGVEYLAANATDPGATDLPGIAGAFDVVTAVYVLPYAPTREAL"
     misc_feature    complement(16183..16201)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.37"
                     /tool="antismash"
     misc_feature    16265..16274
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.11"
                     /tool="antismash"
     gene            complement(16786..17667)
                     /locus_tag="AB852_RS09065"
                     /old_locus_tag="AB852_08875"
     CDS             complement(16786..17667)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024852.4"
                     /locus_tag="AB852_RS09065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_08875"
                     /product="NAD-dependent epimerase/dehydratase family
                     protein"
                     /protein_id="WP_073785881.1"
                     /transl_table=11
                     /translation="MDIFITGASGYIGSALTRTLVARGHRVRGLARSDAAEARVRGNGG
                     DPVRGSLTDLAVLAAQAAGGDAVVHTAATDTADRPAVDAAAVTAMLDAMEGGVFITTTG
                     APRARSSRTPVTEDDTAEPTGPLAWLAPAEARVLEAPRVRGVVVRPPMVYGDGGGPLAR
                     LVGQAGADGVARYTGPGDNHWSTVQVNDLATGYATLLEQPAQGVFHIAEPVPVDMASLA
                     AAIGEAARVPVASWSLAEALETHGPLAGFLAMDAALDASRLRSLGWSPVFGEALGGICG
                     ALRNPVQGYRAS"
     gene            17836..18792
                     /locus_tag="AB852_RS09070"
                     /old_locus_tag="AB852_08880"
     CDS             17836..18792
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024260.4"
                     /locus_tag="AB852_RS09070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_08880"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_073785883.1"
                     /transl_table=11
                     /translation="MRDRSGPDALGTLLGRIRVGTARFGRIELGAPWGVRMGPRDTVTL
                     HHPLDGEMWLDADGRTARIGPGDLVILPHGVPHSLKYRPDARVMMEEQRHGPLPEGGLS
                     VRRSFGGDGVRTVVLCAELALTGAARGLLLRALPPVIHLGPNAGGDPLPGLRRILDALR
                     EEVRDGRSASPLLAARLVEVLLLQGIRAELERPAAAGTWRAALGDDRVGRALDALYKAP
                     GHPWSVAELARVADMSRAAFAPLFRELVGESPIAHLTAWRMALAKTALCEQPDLPVGRI
                     AASVGYGSEFAFSAAFRRVVGMPPGRYRATTRTTSTP"
     misc_feature    complement(18809..18824)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 22.0"
                     /tool="antismash"
     gene            19279..21378
                     /locus_tag="AB852_RS09075"
                     /old_locus_tag="AB852_08885"
     CDS             19279..21378
                     /GO_process="GO:0042546 - cell wall biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005475086.1"
                     /locus_tag="AB852_RS09075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_08885"
                     /product="SMI1/KNR4 family protein"
                     /protein_id="WP_073785885.1"
                     /transl_table=11
                     /translation="MTSTDETTSETPFDWREFLARWSGEWADAQDPHEQDEWDPELTAA
                     RWLGCPGASDADIAALEERIGHRLPPSLDTFLRISDGWRPEDHPVYRLAGTREIDPHEN
                     ANGLAEIFAEGLDEDASPQELLEAGMWHRAFRLDAETDATLVLIDPLDRDADGEWAVYE
                     WAYWRAAPPDRFPSFRHYMLERYRSFHSSAAHKAAHGEGPAFVNDTTRAQDAVVELARR
                     AALGGEYEEALTLLREAGEYGRPRAGLLRGQLDCLLSAQASAYSVDVLAVDPVYAPDLL
                     PVAAAGFATTDRHDSRTGQSWALLARCTTPEAVERAEEALRAAREGTYRFTAEGPLGEA
                     ADKARELARWGRWNEAWRLLWAALPHWRPLGPDHMAPLGLLADPVLGPVITPERGRLLL
                     ALPRGEFARPERELPGTVLGPVGEAPGDDPVGLSWLEDEVPDRFDGGYRAVFVADPDPA
                     GLPARLKDPGGGGPGPGGRPQREVTPGPDGLYPPRSTWDADHRLGLALGSTSYDDRALA
                     WVGQAAPGWSFAFDGRARGFGEERFVSPAAAASQGTRAVVVWHSVGTFDRTRTRFHLSA
                     GVDGEEVCAFTVTAGDVDPHWTGEIPPWLSLDGFPGTTGEWRGDEDPWTDADDRNTPDR
                     GLPGTRGALAALERALGLTLPRTALLEGPLHSFVTRSWTRPPGPGESYATLIITTSLPD
                     PGENA"
     gene            complement(21728..22078)
                     /locus_tag="AB852_RS09085"
                     /old_locus_tag="AB852_08895"
     CDS             complement(21728..22078)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358634.1"
                     /locus_tag="AB852_RS09085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_08895"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_073785889.1"
                     /transl_table=11
                     /translation="MRIGELANAAGVSTRALRYYEQRGLLQARRQGNGYREYDESAVIR
                     VHNVRALLDAGLKVDDIRELNLCLDEKQLEHIPTCEAYVLYQQRLRAVQAQLAALTEVE
                     SRLRAKLAGVPK"
     gene            complement(22184..23380)
                     /locus_tag="AB852_RS09090"
                     /old_locus_tag="AB852_08900"
     CDS             complement(22184..23380)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="AB852_RS09090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_08900"
                     /product="MFS transporter"
                     /protein_id="WP_218623242.1"
                     /transl_table=11
                     /translation="MGLLLTTFVIGTDDFVIAGILPEISADLRVSEGAAGQLVTVFSIT
                     YAIACPVLAVATSRVPRKALIVGGLAVFAVVNFITALAPSFGTLMALRVVAALVAATLS
                     PAAFAVAGRLAAPERTGRAIGTVAAGLTLSLVAGVPFGSWVSGVWQWEATFIAVGAFSC
                     LAVAITALMLPSIPQTRVIGVAERLRLLRRPPVLLCVLGTMLAACGGLMPYIYMAPITH
                     DLTGVGGQYVGVFIAIVGVSGAVGTVLGGRLTDRWGVDRTLLAAFGGVVVAALVLLAVG
                     GIGQGTVPVWVVGVVLVLWGVPGWGNNPPMNARAMHMGGDAATEALALNTSGLYAGIAL
                     AGAIGGGAVNASGGIGVLVVACVAGLITIVVMAMSVRRYPSPTRAPEGGTAPREVARP"
     misc_feature    complement(23424..23439)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.33"
                     /tool="antismash"
     misc_feature    complement(23976..23988)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.63"
                     /tool="antismash"
     misc_feature    complement(24884..24898)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.71"
                     /tool="antismash"
ORIGIN
        1 ctatccgcac gacgaccaac cacaggaggt tcacatgccc cgtaccgtca tcgcaggcgt
       61 cgatggttcg cgcgagagtc tgtcggccgt ggagtgggca gccggtgagg cttcgcggcg
      121 aggactgccg cttcggctgc tccatgtccg ggacacctca cccggggttc gcgccttttt
      181 tgccggtgcc gggagagcac tctggcccga tggcggaccg caggcggcga tcgagggcct
      241 ccaggcccgg cacccgggcc tcgaagtgac aaccgacgac atacctggca ggcccgccga
      301 aaccctctgc acggcgaagg accaggagct gctggtcctc ggctcacggg ggctgggccg
      361 actggcggga ttcctcctcg gctccgcctc actggcggtc atcgcccgca gcaccgcgcc
      421 ggtcgtcctc gtgcgcgcca aggacacgtc atccgcccag gagtggcagt cgtccggcga
      481 tgtcgtggtg ggcctggaca cttcccaccg gtcggacgcc gtgctggaat tcggcttcgc
      541 ccacgcggaa cggcacagcc tcgcgctgcg ggcgctgcac agctggcagg ttccccaggt
      601 gtacggcggc gatccgacgg gcgcgatgct gtcggcccag acagatctgg ccacggtgac
      661 gagcgaagtc cttacggaga ttctggcgcc ctggcgggag aagttcccca ccgtcgccgt
      721 gaccgagcgg tgtcggctcg gtcaccccgc gcacgacctc gtggaggcat cgcgcgatgc
      781 cggtctcctc gtcgtgggcc gcagggagcg ccgggtgggc gtcggcgcgc acatcggctc
      841 cgtcgcgcac gccgtgctgc accactcgaa ggccgcggtg gccgtggtgc cccacgcctg
      901 atcccatgcg agcgctctgc cagggagggc aggggcggac acaccgcccc tgccctcccc
      961 cgctctcggc cgacgacagg caagctgtgc catgtccccc acttcagcgc ccgcgctacg
     1021 ccaggggccg caccacacgg ggccgggaac aactcggtct gccccgccag gatgtggcag
     1081 cacgctgcga cccggtgccc ggatacctca cggaggaaca gcgggccttc agcaggcatc
     1141 ggcttcctgg cctcctcccg gcaatgcccg tgcaacccca actgccgtga tcggcaacgc
     1201 agtcgaccag gacacgccca agccgcctgc ccacaccgcg tcccgttcca tgcgtcctcg
     1261 accggtacga ggacgcgcga ccccgtacca gcttgggccc cggcctcccc tcggaacgcg
     1321 acgcccgcgc tcggtggcga ggcgaacccc actgacgcag caactggcac ggcaccgccg
     1381 tcgggaaggt ctgccccgcc ctaaggtccg gccgccggga cacgccacac cagtcgagtt
     1441 ccgccgccgg ggggcgagga caactccatc gtgccgccgc agcgttccgc ccggtccgac
     1501 aggttccgca gaccgctgtg ccgcccgctc ccctcgatcc cgaccccgtc gtcggctacg
     1561 gtcagggtca cttcacggcc gttggtccgc agcgtcactt ccacccggct cgcgcgcgcg
     1621 tggcggacga cgttggccag actctcgccc aggacggcca agaggtggtc ggcgacgaac
     1681 cgggagacct gggtgtcgag caggccctct ttgcgcagac cgggcgagaa gcccaggctc
     1741 gccgccgcga cggccacggc ccgcaccgta cgggcccgca gtctctcccc ctcgccttcg
     1801 acctgcgtcc gcagcccgaa gatcgtggag cggatgatct tgatggttgc gtccaggtcg
     1861 tcgaccgcac gttccacccg ttccgacgcc tcggggtggt cgatgaagcg tccagcgctc
     1921 tgcaacgtca tccccgtggc gaacagtcgc tgaatcgcca gatcgtgcag atcgcgcgcg
     1981 atccggtcgc gttcctcaag cagcacgatc tgctcggtgt cgctccggcg ttccgccagc
     2041 tccatggcca ccgcggccgt accggcgaat cccagaacgg ggcggatctc ctcggcgagg
     2101 aacggcgcac gacccgaggc acggacaagc agcaggaccc cgcgcacgcc ggcgccggtg
     2161 ccgatgggaa tcgccacgcc cggacccagc ccggtcggtc cgcccaagta cgccgcggga
     2221 cctggatcat ccatgtcctc actggtgacc ggcacagcac gggtgaacgc cgtaccgatc
     2281 agtccgctgg acaccgccag acgcagagct cggtaccggt cggcctccag accgtcggcc
     2341 agctccacga ccagcgagtc ccggtcggca gcgggcagcg cgaccacgac cagatcggcg
     2401 cccgcgatct ctcgcgcccg gtcggcgatc agagcgagca ccacagcgcg ctcactgccc
     2461 gacagcaggc tctgcgtgac ctcggccgtc gcctggagcc acagctcccg ctgctgggac
     2521 ctctcgtaca gtcgggcgtt gtcgatggcc acgcccgccg ccacggccag ggtggtcagg
     2581 atcgactcgt cctcggcgtc gaactgggca ccacccagtt tctcggtgag gtacagattg
     2641 ccgaacacct ggccgcgtat ccggatcggc actcccagaa aggtgctcat cggggggtga
     2701 ccggccggga agccgtagga agaggcgtgc tcggagagtt tcgccagacg caggggctca
     2761 gggtgagcga ccagctcgcc gaggatgccg tggccggacg gcgacgagcc gatcacggcg
     2821 gcctctgcgt cgtccacacc gacggtcagg aactggacga gcttctcgtg atccggaccg
     2881 atgaccccga gggccccgta tcgcgcacgc accagagccg tcgccgcctt caccacatgc
     2941 cgcaggacgt gttccagttc caggtcacgc ccgacggaca tcaccacttc catgaggtcc
     3001 tgaacccggt cacgcgtgct gtgcgccgca tccagccgcc cctgcaacag agcgagctgc
     3061 tcatcgcact cctgccgccc gccctgtgcg ggccgggctc cgctgtcctg tgcgtgtgtc
     3121 accgaacacg ctcctcgggc tgcctcagga gacccgctgt cacgggcgcg agtgcccgga
     3181 cgggccgaag caccggctca cggccaaacc gaccgcgctg cgggctcatc ggccggggcc
     3241 acggtaccga tcgggatccg cccgtccgga accgtccgaa cccgctctcg cggcggcggc
     3301 cggcctcccc tccgccgcgc cggacacctg ggtggcgatg accgccgcct gcacacgccg
     3361 ctcgacaccg agcttcgcca gcacgcgaga tatgtgattc ttgaccgtct tctcggcgag
     3421 aaagacccgc agaccgatct cacgattggt caggccctcg ccgatcagcg cgaggatgtc
     3481 acgttcacgg ctggtcagac cgtacagagc gtccgccgcc gactcgtcgc ggtcctcacc
     3541 ccgcagccgc gacatcaacc gggccgccgc gctgggatcc agcaaggact tgcccgaggc
     3601 caccgtgcgc acggccgcaa caagatcgcc gccctggatc agcttcagca catacccgga
     3661 cgccccggcc atgacggcgt ccagcagggc ctcctcgtca tcgaaagacg tcagcatcag
     3721 gcaggcgagg tcgggcattc gtgagcgcag ctcccggcag acgtccactc cgtttccgtc
     3781 ggggagccgc acatcgagca ccgccacgtc cgggcgcagc gccgggaccc gcgtcagagc
     3841 ctgttccgcg gtccccgcct caccgaccac gctgatgtcc ggctcgtcgc cgaggagatc
     3901 acgcacaccg cgcctcacca cttcgtgatc gtccaagagg aaaacccgga tcggattctc
     3961 aggaccgcgt gaaccgctgt ccggcatgga ccgctcctca gtgctgtcga tcgcgcagtc
     4021 cgcgggaaca ggggcccccg ctcagccaag actccagcat tcctccattt gcggctagtg
     4081 atccgagtcg aagattcatc gacaatggtc gaccacctcg cccgcaccac cgcggtcacc
     4141 tggccgcccg gtaggaggcc gcgcagcggg aggcgctgat cggcggcgat ctctacagcg
     4201 cgtgctccac cccgcacggt gtacggctgg tcatgggcga cgtccggggc aagggcatca
     4261 ccgcgatcga gaccgtcccc atcgtcctgg gcgccttccg cgaggcgtcg cacgacgaga
     4321 ggacactccc cgaggtggcg gcccgcctgg agaaaacgct ggaccgggac cgcgcggacc
     4381 ggaacggtgg ccacgacctg gaactccgcc tgacgggcag acgctttccg acccccgccc
     4441 gcctcctcag caccctcgtc gacgacgtac aacgcttctc gggcggcctc accgcgacga
     4501 catggccctc ctcgccaccc acaagccgct gccccgcccg gcacgccgaa gccgttgcga
     4561 gcgcggatcg cgggcggctt cgggtggtag acgtcgccgg accgtacgag gtacccgccc
     4621 cggccgtcct tcttccggat ggccggctac tggagggcac cacgttgatc agccggcgac
     4681 ggcccgcacc tcgcacggtg gtctaattcc ggacacgtta cctgtgcgga cgtggacacg
     4741 acgcattgcc ctgtcaaggg catttctcat gaggcagaag tgattctcat cgaatcctca
     4801 cctcaacacc cccgcgcatc cggccaccca ctcgacgcga aaagaaccag ccaccggctg
     4861 tccagtttca aaatgaccac ttcacaccga accgagaatt cgtcccttct ccggcactcc
     4921 aacggcctgt actcatgacg caagcggccc gaattcatca tctggccgcg tacagccgtg
     4981 aatcaggggg tctctctgtc atgaccaaac tcacccgacg ccaagccttc ggcaccgtcg
     5041 cgggtgccgc agcgggcata gccgtggccg gaatagccgt agcttccgcg aacgccacac
     5101 cggacaaggc cagccggtcc accaccgcag caaccggaac cgcagccggc acgaagcacc
     5161 accacacagc cgtcccggcg cccttcagcg aagtcttcga agggcgtcgt atccagggca
     5221 tacccggcga cgccaacgcc aagagcgagg cgcacgggca gcatcacaca tccgccaccg
     5281 gctatcgcgt cctgatcgac ggccgggaac tgcatgtgat gcagaaaccg gacagcagct
     5341 ggaccagcgt gatgaaccat taccagacgt tcccggaccc acacaccacc gcccgcgccg
     5401 cggtgacctc gctcatgggc gccgacctcg tcccccacac ccccaccgcc tgaaccggga
     5461 gcagccgcca tgaccgtacg gaagaatcag gcgaacctca cccccgccga gaagcgagcc
     5521 ttcgtcaacg ccgtggtgga actcaagcgg agaggccggt acgacccctt cgtcaccact
     5581 catcgcgaga tcttcatctc cgatatgacg ggcccgatac ggcaggggca cgaatcaccg
     5641 tcgttcctgc cgtggcaccg ccaatatctg atcgacttcg agcgggcact ccagtcgatc
     5701 aaccccaatg tgtccatccc gtactgggac tggaccaggg accggacgcc cacatcctcc
     5761 ctctggtcgg ccaacttcct cggtggaaac ggccggcggc cggacggaca ggtgatgaac
     5821 ggccccttcg cccactccaa cggcaactgg agcatcaccg tccaggacga caccgcgccc
     5881 ttcctccggc gtgccatggc gccaacgggc atgccactgc cgaccagggc cgagctgaac
     5941 accgttctcg ccgtcactcc gtatgacacg acgccatggg acttcaccgc cccggggttc
     6001 cgcaacagcc tcgaaggcgg agccggtccg ggcctgcaca acagggtgca caactgggtc
     6061 ggcgggcaga tgctgcagag cgtgtctccc aatgatccgg tcttctggct gcaccactgt
     6121 ttcgtcgaca agatctgggc ggactggcag cggcgccacc cgcagcactc ctatctgccc
     6181 gcagtgagca ccacgggcgt ggtggcgctc aaccaggcca tggccccgtg gaacaacgtc
     6241 accccggccg cgatgctcga ccacacccgc ttctacacct acgcctagcg atggttcgtc
     6301 aaaccgggcg gtagagatca ggtgggcgtc agcgtctcag cccgtggatc cttacggctt
     6361 cggccaggtc aaccgcggct gcgggctggg ggtaccgggc cggggcaggt cggtggccgt
     6421 accaggtcga ctcgcgggca gggtctgcgg gtgggcgatg gccacgacga ggcggacgtt
     6481 gccgtcagtt ccccggcgat gcctcggcag cccaccaggt gatggtgtgt ccgtcgcgga
     6541 aggccgctac cgcccgtgac gtcactccgg cctgtttggc tttgcgggcc ggttcgccgg
     6601 cagcttgctg cggaagcctg ggcccttctt gccagtcagg aagtggtggg tggggatgta
     6661 cggcaccgcg tgcagcgggt agcacagacg ctcatcggcc agcaggtcgt caccgtgacc
     6721 acgccgcggt cgaccttgcc atcgacgtgg cggcgtgctg atcttcctcg aagagatcaa
     6781 cgcctccatg gagcagccgg cccactgttc gggagaagcc ccgtgagccc ggcgacccga
     6841 agatctcccc ggccgtcgtt gccctcaacg aggtcctcga cgactgcggg cagcccgcgc
     6901 ccagcccggc accactcgac gggccgggct gggcgcgggg tgaaatgttg cctccgtgcc
     6961 agccctctcc ggcttggggc gttgaggcgg cagggcggtc cggcggagca gtccccgggc
     7021 ctatggggcc ggatgcggcc ggagctggag cagtcttcga gcaggtgggt ccaggcgggc
     7081 ctcggaccgt ccgttcggct ccgccgtacc acgagggacg ctcactcttc ggctatcaga
     7141 agatctcgat ccgagtcacc ttgtgcacgt ggccggggtt ccacgcactc cattttccca
     7201 tggtgacgct ttcgatcctc gggttgccca cactcctctg gaactgaatt tccgctctgt
     7261 tgttgcctga ctcaatccag ttgatgccat agatggcgac gcccatgaac ccgcggtcgg
     7321 cgaaacagag aacgctctga ccgttgttgc cgtggacctc cagatagtcg gtccggtcgc
     7381 aactcacgcg gtggatgagc ggtgagacac ggtcgcttgc ggcgctggct ggtagagccg
     7441 ttgcagccag ggcggccatc gtggcggcaa tgactccgag agttcgacgt aaggacgatt
     7501 tcatacttcc tccagcgttt gttgcggaca tgtgcccgta cgtgacgagc acatccagat
     7561 cttcggaact cttgcgtatc ccacgcccat ggtggccagt agggtggtcc gtaaccgcag
     7621 ggctgaactc gtggggcatt tccatggctt cgcccggctg cgagaacagc gcgaccgggg
     7681 agaacccgtt tcaccgcagt gcccgggcgg acagtttgcc ggggcatggt gcgactaccc
     7741 ggcttcagtc tcccgccgga ctctcgcctg ccactggact ctacgggcgg cggctcggcg
     7801 ggcgattgaa ccttcgcgac atgccgattg aatatcggcg ccacgagata ggaacgccac
     7861 accgagagag gcggatcgac gggcgatggc aggtactgag gcaggggccg acgactcgcg
     7921 gggggcgttc tccctggaca ccactacccc gggtccctta ccgcgaggat tcgccagctt
     7981 ccgccgcgag tgggagacac aggtcggtga cggcttcccg ctaccgacct tcagcccggc
     8041 cacgacgggc gacttccggg tcgagggccg cgtcgcgaag gtacgcgatg cggcgatcac
     8101 cgatgtcaac tgcgcatcag ccatccggac cgccgccctc ggcgatgtcg aggatcaggt
     8161 gcggatgtgg gtcgtgcagc gcggcgcatg gactcttggc ggccccggtg atgagcacac
     8221 cgtatccgcc gggcagttcc tccttcggca cgtcgggcgg ccctcgcact tcgcgacggc
     8281 cccacacacg acggcgaaga tcgtcgtact acccgccacc atgctcaaac cgttgctcgg
     8341 gaaccagatc gttgccggct cgctggactc ggccgaggtg cgcctgctcg tggctcacac
     8401 gaacatgatc cacgccaacg tgaccgacct cggcccggcc ggtgtgcgag ccgcccacag
     8461 cgctctgatc gaactggcca aggcggtggc aggacaccgg ttcgacgaca aggaaccctt
     8521 actggcttcc gccctcgccc aggccgcgaa ggacctggcg gacagccgac tcaccgaccc
     8581 ctccctctcc tccagcatgc tcgcaagcga actcagtgtc tccgtacgca ctctgcaacg
     8641 ggcgttcgcc acaggaggag aaccagtgac cgcctacatc cgccgcaggc ggctggaaga
     8701 agcgcggctc gccctcaccg caccgttcgg ccggctgaac atctcggaac tcgccgccca
     8761 ctggcagttc gcggacagca gccacttcat ccgggccttc aagacacact atggccagac
     8821 acccaccgac catgccggcc gggcaaggtc ccgaaaggaa tgaagtcccc ccggcgaaga
     8881 cgagtggggg cacctgcaca gcctcgccac cctggaggtc ttcgggcccg ccgcgatcgt
     8941 cggcggccac caggcggagt tcttccgctc ggccatgcgg aacatgggcc tgagaccaca
     9001 gttcgccact gatctcagcg acgggcctgt cactcccgtg cacagctggc gtgagccgag
     9061 cactgcctgg tgtcgttcct ctcgcgcggc gccctcgtga tgtcacgcgg cgtgcttcac
     9121 cgcggtgcgg tgaccgttcg accgggcttt cacggcaaca gatgactgcc agtaccagaa
     9181 gaagctcaga ctgccagagc ttccttcccc tcgctagcgt gatcgaaatg ctcggactcg
     9241 cggtccggtc ccggtacgaa tggctgagat tcgaggacgt ctacgccact tcggcctggg
     9301 catcgatact cgtcagcgcc ggtgtcgtcg aatggttcgt cgtccaccgc accctcaagc
     9361 ccctcgcccg cagaccccgc ccgcgcggga ctcccgccgt caccccagga ggggcgacca
     9421 ccattccccg cacaggacgc atacccgcgt aacgaacgat cccaggggct gaggtgtcac
     9481 acgtcgagtg cgtgggcgcg gtggggccgt gcggtcgcct cgtcgttcgg tgtgccggta
     9541 tcgaggcagc gtgcagaata cccacgagcc gttcggcgag ttggcgccgg gcagcgtttt
     9601 tgctcaaccc ggcttcatgg atgaggagtt gcatatggag gcacaggact cgcaggacac
     9661 ggccaagagg ctgcgggcca tctgcaacga agtgtcggac cgcttctttg agcgggctga
     9721 cgtggtgcga actctcgtga tgacgctgtt ggccggccag cactcgctgg tactcggccc
     9781 gcccggaacg gcgaagtctg agatggcccg ggagctcacg ggcagggtcg agggtgcgac
     9841 ctactgggaa atcctccttt cgaagttcac cgcgccgaca aggatcttcg gtcccatcga
     9901 cgtcgccgca ctggcccggg gtgagtaccg tcaggtctac gagggccgcg ccacgacggc
     9961 gcacatcgcg ttcatcgacg agatcttcaa atgctccacg gcggcgctga acgagacgtt
    10021 gggcttcctg aatgaacggc tctaccaccc agagaacggc ggcaaaccac tctcctgccc
    10081 gttgatcgga gccatcacgg cgagcaacga actgcctatc ggagaggatt cggccgcgat
    10141 ctacgaccgg ctgctggtgc ggatcgaagt cgggtatctg gctgacccat cgaacttcgc
    10201 cgcgctggtg cgctccgccg tcaaccgacc ggccccgttg acgcggacca cggtcgaact
    10261 gagcgcattg cagcacgccg tggccgaagc cgtcccggcc gtggatctcc ccgatgtgat
    10321 ggtggacgcg gtgtgtacgc tgcgagccgc cctgcgccgc aaggaactca tcgcctctga
    10381 ccgccgctgg cggcaggcgg tggggctgct ccaggcatct gcgttcctgg atggccgccc
    10441 agcggtcacc gaggccgatc tggcggtact cacccacgtg ctgtgggact cccccaccga
    10501 gcgcccgacc gtcgaacgcg aagtactgca gctggtcaac cccgatgcca aggaggcact
    10561 cgacctggcc gatgtcatcg aggagctgga ggcccagctc gaagccatgg ccgggcagtc
    10621 acgcgaggcg ctgagcgagt gggtcatcaa gaaggcccac aacaagctcg ccacagccgg
    10681 gaacaggttg gcgaagctgc gtaaggaggc agcgggcgcc gggcggtcca ctgccgccat
    10741 cgaccgagtc accggccgcc agcgcgccgt tcgcgcccgt gttctcaccg aggccctcgg
    10801 catggacgcg agcatggtgc agacccagct ctgagcaccg ggaggtcaca gccatgggca
    10861 ggactccgag caggcacaac gagtcgtcga gccgggccgg ggggaagctg agcacctccg
    10921 ccacagctcc cgagcggcac cgcacaaccg tcgtcgtgga ccgcttcgac cagatctcct
    10981 ggcgcgacac ctacgagcag tcggccggac tcagcgagct ggccaaggag ctgaacgagc
    11041 gctatggctg cggcgccgac ctcttggccg acgcgtttca ggccgcctac aaggtcagtg
    11101 cgcggttgcg cgagcgcgcg gagatggacc gctcccgatt ggtcaaccac cagatcatca
    11161 ccgcattggc agagtcatgt gagttcgccg agctgcgccg ggtgacggtc ggcgacccct
    11221 atgccgcagc catggccgta ctcgcccagg cccccgcact gcgccggatg ctggaacact
    11281 cccgcaacgc ccaggaacaa gctgagcagg tggagaaggc ccagcagaat gccgcaagcg
    11341 atgcaaccac tctgtgcgag gcgctccgac gaacagccgg cagcgccgac gaggacaccg
    11401 cagtctcggc atccgacgcc gtacaacatt ccatcaaggc ggccacagct gccgcgcggc
    11461 agagcgaccg aagtgccgcg caggccctcc cggcggcggc acccggtatg ggtgccaccg
    11521 cgcgcagtgc ggcgatgaag gccgtcgaga tcgtgcgagg ggaagccgcg ctgatgcggg
    11581 catggggcat tggtccaggc gagctggaga aaatgccgtt cgaccagcgc gctcagctcg
    11641 ccgagcggct gcgcaccggc cgtctcgcgc agtgggccga gctgatcggt cgattccggc
    11701 agatggcgag cggtgaacgc gcccgaaagg tggcgaacgc caccggggag ctggtcggcg
    11761 tcacgctcgg cgatgatctc tcccgcgtca tcccctccga actcgtcaac ctcggcctgc
    11821 cggagctgcg tgcagtgttc gccgcgcgct acgccgcagg ggagctgatg ctctaccaca
    11881 gtcaggggga gcaggccacc ggccagggcg ccatcatcgc gtgcgtagac acctcgcact
    11941 ccatgtacct cgcggggcgg gacggggtca gccgtgaggc gtgggccaag gcatgcgccc
    12001 tggcgctgct ggaccaggcc cgccatgcca agcgtgactt cgtcggcatc ctgttctccg
    12061 ctgccgacaa gatccaggtc ttccgcttcc cggccggcca acccgccgac ccagcccagg
    12121 tgctcgactt cgcggagacc ttcctcggcg gtggcaccag ctaccagacg cccctgactg
    12181 cggccggcga actactggca gaggagctca acgacgccgc ccgtggacgt ggcgacatcg
    12241 tgatgatcac cgacgatgag tgcggcatcg ccgaggagtg gatgcgtggc tggaacatcg
    12301 ccaagcatcg gttgggcttc cgtgtcttcg gcgtggccat cggcgccccg cgcgccaccg
    12361 aagccgactc ggtcctggac gccctgtgcg acaacctccg ctccatcgag gacctcactg
    12421 atgtctccgc cgccgctgac ctcttccgca tgatctaaac ccctttgagg tggaaaatgc
    12481 cgttgctttg gtcgggtagc cggttgtttc aaggccacga cgattggtgg tcgacggcgg
    12541 ctggagggtt cgcctggagc tttgccggcg tagccggtga tgcaggaacg gatcttgcgg
    12601 gggcagccac gggatcttcg cggggtagga ggctgtgacc gatttcgggg agttcgaggc
    12661 gtcggtcccg ctcgtgggct gagagggaaa agccgctcgg tgagatcact gagcggcgga
    12721 caacgtccag ggcccgggtg aacgaggtcc gttcggcagt gctgtggcgc cagcaggcgg
    12781 ccacgtcgag cgggccccgg gtgctcggcc cgggtgaggg cctggtcggt ggagcgggtc
    12841 ggcgatcgag gtgatggggc ggccggggtc gggtagcggg tcgcgggcgg cttcggtgac
    12901 tttcccggtg gcggcgttgg ggcatctgcc gacccggccg cgggcggcgg ccaggacctc
    12961 gcgggctgca cgcctctgag cgggtggttt acgacagccg tgaggaagtc gcccggcacg
    13021 atcggctcat cgcctgcggc gctgcccgcc ttggcctcga ccactacctg gaggccctga
    13081 tccggaaacc gggtgccctg cccggcgcca ccgcccttga ccaggcccgc gccgtcggcc
    13141 gttccgcacc catccacgac gcctggtggc aagccgcagt gaaggcggcg cacgggaggg
    13201 cacccgggcc cggatcgaag tccccctccg cccgttgggg acatcggctc gtcgccggac
    13261 cgtgggacag gtggtccgtc accaggtgac gggcagttcc accggccggg tgaagagata
    13321 ggtgtccggt tcccaggcga tgtcctcgtg tttggccgcc agggccaggt ccggcaggtg
    13381 tgagaacagg gtggagagcg cggtctccaa gtacatgcgg gcgatgttga cgccgaggca
    13441 gaagtggggg ccggtgccga aggtgatggc cgggtcctcc tgcgcactgc ggtcgaggcg
    13501 gaatcgttct ggttgtttgt agtgttccgg gtcccaggtc gcggcgaccc agggggtgat
    13561 gacggcgtcg ccggcccgga tgagtacccc gtgcatttcg gtgtcggtca acgcgaggcg
    13621 gggcatggag gtcatgccgt tgtggtgcag ccgtaggagt tcggccaccg cgtcgggcca
    13681 cagggtgggg tcgcgctgta tccgggcgag ttggtcgcca tgtcgcagca gggtgtacac
    13741 gccggtggtg acggggccgg tgaccggttc ggcggaggtg acgaagaggt acatcaccgt
    13801 ggcgtgcatc tgctcccggg tgatggtccc gtgacggtgg gcgcggatca gtgcctccac
    13861 cgggtcccgc ggttcgcggt tgtcgtcgta gtccgccgac ttggcgtcga tgacttcgtc
    13921 agcgaagtcg agcatccacc gggtggacgt gtcgatggcg gaagccggtg tcgtgtagtc
    13981 gacctgggaa cgtagccggg gcacgatctt gcggcgttgc cggggtgcca cgcgcatgag
    14041 gtcgcaagcc agtgtcgccg ccagcggatg cgcgtaagcg cggtgcaggt cagcggggtt
    14101 ggggccatcg cgtagcgccg tcgccaggtc ggtggcggcc agggcgaccg cgggcctgag
    14161 ggcggtcgcg gcggcagggt tgaagaacgg ctggaccacg cgccgcacgg tggtgtgcgc
    14221 ggggggatcg aggttgaaga tgccgcccgg cacgctgttg aagtcgtctc cggcgatgcg
    14281 ctgcccgccc gggcaggtga gatcgcgcga gaagctgcgg ctcgatccga tggcggtgat
    14341 gtcggcgcgg cgggtgacga gccacgcgtg gtggccggag gggaacgcca cccgggcgac
    14401 cggccgctcg cgtcgcagga ggtcgaacat ctccggtggc agcccgtgtc cgcgggtggg
    14461 aaaggagtcg ggccaggtca ggtcatcggg aatcgtggtc atcacggtcg ttcctctcgt
    14521 cggtgagcac ggacaggaca tggcccgacc cgatggtgag accgggaacc tgaccgtcgg
    14581 ccaccacgtc gtagacgggc acccggcggt ggtacacgaa cagggcacgg ggtcgcgcca
    14641 gcactccggt cgagtccagc agcagcgggg actcggcgaa gatgtagcgg gtgttgtcct
    14701 cgatctgggc gggggtgggc tcggagtcga tggaggcttc cagggccgtg cgggtcatcg
    14761 cgcacaccgc ctcccgcatc ggggtctgcg tgcggtacgc cgtctcgatg cgggtccgga
    14821 cctcccggta gcgcgggtgt gcggcgaagc gggtcagtac gtggaccctg gagtccgtgt
    14881 cgggcacccc gcaatcggcc agggtgcgac gcgccacatt gcgcatgttg tggatgacgc
    14941 gcttggaacg ctggaccgcg cgccgtggcg ccttgcccgc ggagatgtgg cgcagtgctg
    15001 attcgggcgc ccccggaagg accacgtgca catcgtcgaa ggaaaccgac gcgcttcggc
    15061 acagcgcggt cacggtctcc gttgagtaga aggagttgaa cggtgacagg ccgagcacca
    15121 cggtgccgta ccgctcggca aggcgcgggt cgtggaggtc gaggccctcc acccggaacc
    15181 cgctgggagc gatgggctcc tgcggcggcg agggcgggag gtcggtgccg gtgctggcgc
    15241 cggtgccggt gccggtgccg ggtacgtgtg cgtgtgtgtc ctggatctga ctcatgctgg
    15301 tgacctcaat cttctgctgg tcgttctgag tcgggggaac cgcggagagc cggctcatgg
    15361 gagcggggtc tcacttcgcc ggagtggggg cggggttctc caccgggagg ggacggtcgg
    15421 cgggttcgga cccggggccg gcctgcgcgt cgatgatcag cgagtggggg caggtgaggt
    15481 agttctccca gaacgcctct ccgtgcttcg ccaggccctc ttcggagacg gtcgggcgga
    15541 tccacgaaac gcggtcgaag cctgctgtgg ccagggcttg ttcatgcgct gccgcggacc
    15601 agcggaagag gtccaggtcg agcacgtcct gcccgaccca ggcccgcagg tgccccgggg
    15661 tgccctccgc cggtgactgc cgcacactca gacgcatgcc atagccgcgg taccactggg
    15721 ggtccgtgga gaacccgggg ttgagcaccg cggccacgaa ccggccgccc gtcgggcgca
    15781 acgcccgtcg cgcggtgacg cagaacccct ccaacgcctc tcgggtgggg gcgtagggca
    15841 gtacgtacac ggcggtgacc acatcgaacg ccccggcgat accgggcaga tcggtggcgc
    15901 ccggatcggt ggcgttcgcg gccaggtact ccacacccag gccctcgcgc tcctcgcgcc
    15961 ggcgggcgtg ttcgaccatc gcggcggact cgtccatccc gacgacccgg gccgcccccg
    16021 cgccgcgcaa ccggcgggcg tacaacccgc tgccacagcc caggtcgagc acatcccgcc
    16081 cggtgacatc gccgaccgcg ttcaagaagc tgtattcctc tatgtgctcc cgaaaaggca
    16141 tctcttccat gctgcgttca tacgcggcca ccgccgtgtc gaactgggaa tccatcgcca
    16201 tgctcctcgc tcctctgcga tttcgtgtca ggccggcccc aagtccgggg cacgctcgta
    16261 ggcctgtttt tggaaagggg ggtcccggca tcgagccgaa agtcctgcgt aggcccggca
    16321 cccggcccag cgttcgatcg cacgttccgg gccggacggg tgcctcacac cccggtggga
    16381 caccacgaca tgtcgtgtcc ccgagcgagc gggaaccgcc gcaccggcgg ccggttcagc
    16441 ggccatcccc accaaggcgc gacggactcg ctcggtggac atccatcggg ccgccgatac
    16501 cccggtgtga gaaccgttct tcctctccac ccttcttgcc gcgatccggc gccgcaagag
    16561 tccacacgca atcggaagcg tgcacgcgtt gaacgcttgt gcccttgtga agaacggcag
    16621 gcccgaaagg gcccgcgacg cgtgcggacc ctggtagcgg cgcaggcgca gtgacgggcc
    16681 ccgtccgtgg gcgtccagtc agcgtgatcg ctctggaccg gtcggaggcg gccgggacga
    16741 cccggcacac gccgaatgcc ccgacctagc cttccgcgac acccttcagg aagcgcggta
    16801 cccctggacg ggattgcgca gcgcgccgca gatgccgccg agtgcttccc cgaagaccgg
    16861 tgaccagccg agggatcgca gccggctcgc gtcgagcgcc gcgtccatcg ccaggaatcc
    16921 ggccagcggg ccgtgggtct ccagcgcctc ggccaggctc cacgacgcca ccggtacccg
    16981 ggcggcctca ccgatcgcgg ccgccagcga cgccatgtcg accgggaccg gctcggcgat
    17041 atgaaacacc ccttgggcgg gctgttcgag cagcgtggca tacccggtcg cgaggtcgtt
    17101 cacctgcacg gtggaccagt ggttgtcgcc cggaccggtg tagcgcgcca caccgtcggc
    17161 gccggcctgg ccgaccagcc gggcgagcgg tccgccgccg tcgccgtaca ccatcggggg
    17221 gcgcacgaca acgccacgga ctctcggggc ctccagcaca cgcgcctcgg ccggggcaag
    17281 ccaggcgagc ggtccggtgg gctccgcggt gtcgtcctcg gtcaccggtg tccgcgacga
    17341 gcgggcccgc ggcgcaccgg tcgtggtgat gaagacgccg ccctccatcg cgtcgagcat
    17401 ggcggtcacc gccgccgcat cgacggcggg ccggtccgcc gtgtcggtag ccgcggtgtg
    17461 gaccacagcg tcaccgccgg ccgcctgtgc cgccagtacg gcgaggtcgg tgaggctgcc
    17521 ccggaccggg tcgccgccgt tcccccgtac cctggcctcg gccgcgtcac tcctcgccag
    17581 tccgcgcacc cggtggccgc gggcgacgag ggtacgggtc agagccgagc cgatgtagcc
    17641 gctcgcgccg gtgatgaaga tatccatggt ggtgcggtct ccctgttcct tggggtcgtc
    17701 gagagttcca ggcatgctcc ggggccactc gggccttccg ggggctcccg ctctcgggct
    17761 gtcccgggtt cccgggtgtt cgtttgagcg taggaagcgg caggaggggc ggacatgcgc
    17821 ctgagtccag gtgttttgcg cgatcgttca gggccggatg ccctcggtac gctgctcggc
    17881 cggatacggg tcggcaccgc acggttcggg cgcatcgagc tcggcgcgcc atggggggtg
    17941 cggatggggc cccgggacac cgtgaccctg catcatccgc tcgacggcga gatgtggctg
    18001 gacgccgatg ggcggacggc ccggatcggg ccgggggatc tggtgatcct gccgcacggt
    18061 gtcccgcact cgctcaagta ccgcccggac gcccgggtca tgatggagga gcaacggcac
    18121 ggtcccctgc cggaaggcgg attgtcggtg cggcgcagct tcggcggcga cggggtgcgc
    18181 acggtggtgc tgtgcgccga actcgcgctg accggcgcag cacgcggcct tcttctgcgg
    18241 gccctgcctc cggtgatcca tcttgggccg aacgcgggcg gcgatcccct tccggggctg
    18301 cgccggattc tcgacgctct ccgcgaggag gtccgcgacg gccggtccgc ctcgcccctg
    18361 ctcgccgcgc ggttggtcga ggtgctgctg ctccagggga tcagagccga gctggagcgg
    18421 ccggcagcgg ccgggacatg gcgtgccgcg ctcggcgacg atcgcgtggg ccgggcgctc
    18481 gacgcgttgt acaaagcgcc cgggcatcca tggagcgtcg cggagctcgc ccgggtggca
    18541 gatatgagcc gggcggcgtt cgcgccattg ttccgggagc tggtgggcga gagtccgatc
    18601 gcccacctca ccgcctggcg catggcactc gcgaagacgg cgctgtgcga acagcccgat
    18661 ctcccggtcg gccggatcgc cgcatcggtc ggatacggca gcgagttcgc gttcagcgcg
    18721 gcgttccggc gagtggtggg catgccaccg ggccggtacc gcgccaccac gaggaccaca
    18781 agcaccccct gaatccgccg caccgtcctt ccgcccaggg ggatccgagc ctcttcggcc
    18841 cgggcagcac agcgggggat cgcagcaggt ctcccaggca gcggtcacca gacggacggt
    18901 cccgtggccc gggcgcgctc ttcccttcca ggccgcgtga gtgtgtggac atgccgcggg
    18961 cctcgacctg ttccggacac gtgtccgggc aacgcccgct gtctgggatc gagtcccgct
    19021 gcgacgacgg cattcagggg aggctgtcgt cgccggaccg gccgaccagg accgtgttca
    19081 cccaccggtc cgtgtactgg gccggctgcc gatggccccg gtactggtcc gcgacggctc
    19141 ccgcgtacga cgccccgccc cctgggtgtc cagctccacg ctcccgaggg cggtccggcg
    19201 gagaggaaca cctgcacaaa cgatccggca ggagcggcga cgggacccgt tgtcagtggg
    19261 gggtgtcacc ctcaccgtat gacttcgacg gacgagacca cgagcgaaac cccgttcgac
    19321 tggcgggagt tcctcgctcg ctggagcggg gagtgggcgg acgcgcagga cccccatgag
    19381 caggacgaat gggacccgga gctgacggcg gcccggtggc tcggctgtcc gggggcgtcg
    19441 gacgcggata tcgccgccct ggaagagcgg atcgggcatc ggctaccgcc gtcgctcgac
    19501 acgttcctgc ggatcagcga cggctggcgg ccggaggacc accccgtcta ccggctggcg
    19561 gggacccggg aaattgatcc gcacgagaac gccaacggcc tcgccgagat cttcgcggag
    19621 ggtctggacg aggacgcgtc gccgcaggag ctgctggagg ccgggatgtg gcaccgggcg
    19681 ttccgtctgg acgcggagac ggacgcgacg ctggtcctga tcgatccgct ggaccgggac
    19741 gcggacggtg agtgggcggt gtacgagtgg gcgtactggc gggccgcgcc gcccgaccgc
    19801 tttccgtcct tccgccatta catgctggag cgataccggt cctttcacag ctcggccgcc
    19861 cacaaggccg ctcacggcga aggaccggcg ttcgtcaacg acacgacgcg ggcgcaggac
    19921 gccgtggtgg agctggcccg gcgggcggca ctgggcgggg agtacgagga ggccctgacc
    19981 ctgctgcggg aggccggtga gtacggcagg ccgcgggccg gactgctgcg ggggcaattg
    20041 gactgtctgc tctcagcaca agcttcggcg tactcggtcg atgtcctcgc ggtcgacccg
    20101 gtgtacgccc ctgatctgct tccggtggcc gcggcgggct tcgccacgac ggaccggcat
    20161 gacagccgta ccggccagtc gtgggcgctg cttgcccgct gtacgacgcc cgaggcggtg
    20221 gagagggcgg aggaggcgct gcgggcggcg cgggagggga cgtaccgctt cacggccgaa
    20281 gggccgctcg gggaggcggc cgataaggcg cgggagttgg cccgctgggg ccggtggaac
    20341 gaggcgtggc ggctgctgtg ggccgcgctg cctcactggc ggcccctggg ccccgaccat
    20401 atggcaccgc tgggactgct cgcggatccg gtgctgggtc cggtgatcac cccggagcgg
    20461 gggcggttgc tgctggctct gccgcggggc gagttcgcgc ggccggagcg ggagctgccc
    20521 ggtacggtcc tgggtcccgt cggggaggcg ccgggggacg atccggtggg tctgtcctgg
    20581 ctggaggacg aggtgccgga ccggttcgat gggggctatc gggccgtgtt cgtcgcggac
    20641 cccgatccgg cgggcctgcc ggcccgtctg aaggacccgg gcgggggcgg ccccgggccc
    20701 ggcggccggc cgcagcggga agtgacgccc gggccggacg gcttgtaccc gccccgcagc
    20761 acgtgggacg cggaccaccg gctgggcctg gcactcggca gtacgtcgta cgacgaccgc
    20821 gccctggcct gggtcgggca ggcggccccc gggtggagct tcgccttcga cggcagagcc
    20881 aggggcttcg gcgaggagcg cttcgtctcc ccggccgctg ccgcctcgca ggggaccagg
    20941 gcggtggtcg tctggcacag cgtcggcacc ttcgaccgga cccggacccg cttccatctc
    21001 tccgccgggg tcgacggaga ggaggtgtgc gcgttcaccg tcacggccgg ggacgtcgac
    21061 ccgcactgga ccggggagat accgccatgg ctgtcgctcg acggctttcc cggcacgacc
    21121 ggggagtggc ggggcgatga ggacccctgg acggacgcgg acgaccggaa cacccccgac
    21181 cgcgggctgc cggggacgcg gggcgcgctg gccgccctgg agcgggccct gggactgacc
    21241 ctgccccgca ccgccctgct ggaaggcccg ctgcacagct tcgtcacccg ttcgtggacc
    21301 cgtccaccag ggcccggcga gtcgtacgcc accctcatca tcaccacaag cctcccggac
    21361 cccggcgaga acgcgtgaac ctgcctgcgc tccgtatccc gcgccgcgcc cggacggcgc
    21421 caaaggcatc gtccccctgc cggtgatccg ggaccgtggc ggccgtactg agccggcgga
    21481 gcctctggag ctcgttgtcc ttggccgcca ggaccgacag caggcaccgg tggcattcct
    21541 tgagccgcgt gagctcggtg ttgggtccgg gcgagttcgc cggtgagcag ctgaccgcgg
    21601 cctgcgccgc gctgtcctct accgccgcgg ccacgaacag tccgcgcact gccgacggct
    21661 caactcgccg ggcgggaatc ctcaccggtc acggcaggcc cgggcagcgc ggcgggcggg
    21721 acgcggatca cttagggacc ccggcgagct tggcccggag tctgctctcc acctctgtga
    21781 gcgccgccaa ctgggcctgc acggctcgaa gccgctgttg gtacaggacg taggcctcac
    21841 aggtcggaat atgctcaagt tgcttctcgt cgaggcacaa gttgagttcg cgaatgtcgt
    21901 cgactttgag gcctgcgtcg aggagcgccc ggacattgtg cacgcggatg acggcagact
    21961 cgtcgtactc gcggtaccca ttgccctggc gacgggcctg gagcaggccc cgctgttcgt
    22021 agtatcggag agcccgcgtc gaaacaccgg ccgcgttggc aagttctcca atccgcatgc
    22081 gccccccttt tttcaaggcc tgccatgata cccagcgtgc tggtgaacct cttcaccctg
    22141 ctccgcatgg cgtgaacgtg cctggtcgtg aggtggtgac aggttacgga cgggcgacct
    22201 cgcggggagc ggtgccgccc tcgggcgcgc gggtgggaga ggggtagcgg cgtacggaca
    22261 tcgccatcac gacgatggtg atcaggccgg cgacgcaagc gaccaccagg acgccaattc
    22321 cgccggaggc gttgaccgca ccgccgccga tggcaccggc cagcgcgatg cccgcgtaca
    22381 gtccgctggt gttcagcgcc agcgcctcgg tggcggcgtc gccgcccatg tgcatggccc
    22441 tggcgttcat cggagggttg ttgccccatc cgggaacccc ccacagcacc agcacgacgc
    22501 cgaccaccca caccggaacc gtcccctgcc cgatgccgcc gaccgcgagc agcaccagag
    22561 cggccaccac cacgccgccg aacgcggcca gcagggtgcg gtccacaccc caccggtcgg
    22621 tcagccgtcc gcccagcacc gttcccaccg cgcccgagac acccacgatc gcgatgaaca
    22681 cgcccacgta ctgaccgccg acgccggtga gatcgtgggt gatgggggcc atgtagatat
    22741 agggcatcaa cccgccgcag gccgcgagca tcgtgcccag cacgcacagc agcaccgggg
    22801 gccgacgcag caaccgcagc cgctcggcga ccccgatcac ccgggtctgc ggaatcgagg
    22861 gcagcatcag cgccgtgatc gcgaccgcca gacaggagaa cgcccccacc gcgatgaagg
    22921 tggcctccca ctgccacaca ccgctcaccc aggagccgaa aggcacgccg gccaccagcg
    22981 acagggtcag ccccgcggcc acggtgccga tcgccctgcc ggtgcgctcc ggcgcggcca
    23041 gccggccggc gaccgcgaag gccgccggcg agagtgtggc ggccaccagc gccgccacca
    23101 cccgaagcgc catcagcgtc ccgaaggagg gtgccagcgc ggtgatgaag ttgaccaccg
    23161 cgaacactgc cagccctccc acgatcagcg ccttgcgcgg cacccggctg gtggcgaccg
    23221 cgagcaccgg acaggcaatc gcgtaggtga tcgagaacac cgtcaccaac tgacccgccg
    23281 ccccctcgct caccctcaag tcggcggaga tctccggaag gatcccggcg atgacgaagt
    23341 catccgtacc gatgacaaaa gtcgtcagca gcaggcccaa gagccaaccc gaaccggtcg
    23401 ggagcgctat gcgctcgtgt tgcgattcca tgtgtccact ggtccttcgt gcatcctgcg
    23461 cttacggagt cgcccgctac gctaaaacct tgacactgcg tcaatgtcaa cccgtcgttc
    23521 gactgccttc gggcaggtcc gagcgagagg cccgaggcag tgcgcggtca gctgcgcgcc
    23581 ggtcagtttc acacgggcca ggtccgctcc ggacaaggtg gaaccgtgca ggtccgcacc
    23641 agacagatcc gcgtggatca gggccgcgtg gatcagggac atgccggaag gcctcgcatc
    23701 ccgcaggacg gcccgctgcc ccgaggcgac gagctcgacg ctgtcgagcc gggtgccgct
    23761 cgggtccggg cggaagtctc tgtcgtgtga aggggcacgg aaggccagaa cggtgagggc
    23821 cgcacgcatg tcggccgagt cgtcctgact caggatcggc caggaggagt cgtggaccga
    23881 agggagctca tgctccttgt cggcggcgtg ggagcggacg taggaacccg cccagcacgt
    23941 cgtccgccat gcgcctccgc acgacaccca cgccggtgac atcgtcgccg gggcgctctc
    24001 ccggcattcg atggtgcggg ccaccgccgt gatgacggtc gccgccgcgg ccggggccgg
    24061 ggccggggcc accggaccag gcgcggcccg ggccgaaacc gctgccgccg cccggccgac
    24121 gagtttccgg cacggccgga cggacggggc ccagggcctg cgtttcgcac cggtcacccc
    24181 caacgagcac gcgcagttcc tcgggcggga cctggcgcat cccgcggatc gtgacgggta
    24241 tctgcaccgg cccgtcctcc atatgcatgg tcaggtgatg gccccgttcg gtcgtacggt
    24301 ccctccagtg ggtgaaggca agaccggtcg ccctggtagc aacgccggga accacgcggg
    24361 cctgcccctc ggcgtcgctc ccctgatcac agggggacaa cggcccggtg cccgcggctt
    24421 ccgatgaagc cgcgggcacc gggccgttcc cgtgtgccgg ggtcagacac ggcctcccgc
    24481 gttgcggatg cccaggtgct gcgcctgctt cgtgtgctgg ttgtggagcg tgagcagccg
    24541 ggcgatcccg gcggagtcgc cggcggcgaa ggcgtcgatg atctcgtagt gctcgtccac
    24601 ggcgtgggcg ctgggcgcgc cgccgccgct cagcgccgcg gccatgaagc cgggtgtgct
    24661 gagcgcgcgg tagacctgat gcagggtggg attctccgcg agggcgatca ggaagtcgtg
    24721 gaactcgtcg atcgcgacga gatagccgtc gaggtcggtg atccgtccgc cgcgcacatg
    24781 gcgttcggcg gacgcggcga tccgccgcca gcggtcggcc accgccgggc tcaacggccc
    24841 ggggagcgag gcggcgaccc cgagctcgat ggccagccgc ccgtcgaacg cctcgtccga
    24901 ggcccgggtg tcgagcggca cgaggacata gccccgttcc gggtcgcgtc ccacgagccc
    24961 ctcgccgatg agacgggtca tggcgtagta caccgcggac ggcggggtcc gcagccgggc
    25021 cgcgaggtcg tcgacgtcga gactgccgtc gagcggcagc gtgcggtgga cgacgagctc
    25081 ccgcaactgc tcgtacgcgg tggtgtcctg cgccagctcg aaccggccga acctgccgcg
    25141 gaagtacccg aggggggcgc cgtcccgcgc gctggcgccg acgacgcggg cgaggaacac
    25201 ccggtgcgtg ccgccgacga cgtcctcgat cacctcgcac tcaagggcgg cgagcgcggc
    25261 cgagagcacc gggacaccgc ggacaccccg gtcgc
//
