LOCUS       NZ_LFBV01000001        21197 bp    DNA     linear   CON 03-MAY-2024
DEFINITION  Streptomyces uncialis strain DCA2648 scaffold1, whole genome shotgun
            sequence.
ACCESSION   NZ_LFBV01000001
VERSION     NZ_LFBV01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces uncialis
  ORGANISM  Streptomyces uncialis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 2018837)
  AUTHORS   Yan,X., Huang,T., Ge,H. and Shen,B.
  TITLE     Cloning and characterization of the uncialamcin biosynthetic gene
            cluster
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2018837)
  AUTHORS   Yan,X., Huang,T., Ge,H. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-JUN-2015) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33410, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 19-MAY-2015
            Assembly Method                   :: CLC Genomics Workbench v. 8.0.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905345.1-RS_2024_05_03
            Annotation Date                   :: 05/03/2024 03:03:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,456
            CDSs (total)                      :: 7,371
            Genes (coding)                    :: 7,214
            CDSs (with protein)               :: 7,214
            Genes (RNA)                       :: 85
            rRNAs                             :: 6, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1 (5S, 16S)
            partial rRNAs                     :: 5 (23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 157
            CDSs (without protein)            :: 157
            Pseudo Genes (ambiguous residues) :: 0 of 157
            Pseudo Genes (frameshifted)       :: 42 of 157
            Pseudo Genes (incomplete)         :: 143 of 157
            Pseudo Genes (internal stop)      :: 7 of 157
            Pseudo Genes (multiple problems)  :: 33 of 157
            CRISPR Arrays                     :: 14
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:56:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1799047
            Orig. end                         :: 1820244
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LFBV01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21197
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="7"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21197
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21197
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11197](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11197
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    122..138
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.01"
                     /tool="antismash"
     misc_feature    297..312
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.39"
                     /tool="antismash"
     misc_feature    complement(298..309)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.69"
                     /tool="antismash"
     misc_feature    473..482
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 15.86"
                     /tool="antismash"
     gene            complement(572..1537)
                     /locus_tag="AB852_RS07705"
                     /old_locus_tag="AB852_07555"
     CDS             complement(572..1537)
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006127486.1"
                     /locus_tag="AB852_RS07705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_07555"
                     /product="diacylglycerol kinase family protein"
                     /protein_id="WP_073784810.1"
                     /transl_table=11
                     /translation="MRALLVVNPAATTTSARTRDVLIHALASEMKLEAVTTEYRGHARD
                     LARQAAEGDEIDLVVALGGDGTVNEVVNGLMDHGPDPERGPRLAVVPGGSTNVFARALG
                     LPNDAVEATGALLDAIERGSERTVGLGMAKGTPGTADEAIPGRWFTFCAGLGFDAGVVG
                     RVEQQRESGKRSTHALYVRQVVRQFLGEQRRHGSITLEQPGREPIEDLLLSIVCNTAPW
                     SYLGNRPLYAAPRASFDTGLDVLGLTRLTTPAVTRYATQLLTSSPERGPQGKHAVSLHD
                     LNEFTLHSKVPLPLQMDGDHLGLRTSVTFLGVGRALRVIV"
     gene            1659..2111
                     /locus_tag="AB852_RS07710"
                     /old_locus_tag="AB852_07560"
     CDS             1659..2111
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009190564.1"
                     /locus_tag="AB852_RS07710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_07560"
                     /product="hypothetical protein"
                     /protein_id="WP_073784812.1"
                     /transl_table=11
                     /translation="MSAEAKSPRGTDPGGTPEGPRPGRLTAAAALTGLEGAALVAGGLY
                     VSVRGLTGDGSAGQALTAGVTLVALAVLPLVAAKGLLARRGWSRGPAIMTQIISLPVAW
                     TLLQADSMLIPGGIALGVAAVTTLVLLVNPATTVALDIRGPGRADQ"
     gene            complement(2210..3352)
                     /locus_tag="AB852_RS07715"
                     /old_locus_tag="AB852_07565"
     CDS             complement(2210..3352)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011030133.1"
                     /locus_tag="AB852_RS07715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_07565"
                     /product="RNA polymerase sigma factor SigF"
                     /protein_id="WP_073784814.1"
                     /transl_table=11
                     /translation="MRDGDGPVRDEGSGTPGLPAGDPGGPSGRPAPGGIPEQQARSHPE
                     DTLREAADPTGPARSPDTTDVLEQAHPDGPGDTDGRASRSGRGGGPGAPPSGSWGRAGR
                     MSEHERAAEREAGAPGAREVQRSRHEQDRSAARAMFVTLRTLPDGSPEYAELRNKLVRL
                     HLPLVEHLARRFRNRGEPLDDLTQVATIGLIKSVDRFDPERGVEFSTYATPTVVGEIKR
                     HFRDKGWAVRVPRRLQELRLSLTTATAELSQQHGRSPTVHELAEKLAISEEEVLEGLES
                     ANAYSTLSLDVPDTDDESPAVADTLGSEDEALEGVEYRESLKPLLEDLPPREKRILLLR
                     FFGNMTQSQIAQEVGISQMHVSRLLARTLAQLREKLLVEE"
     gene            complement(3349..3762)
                     /locus_tag="AB852_RS07720"
                     /old_locus_tag="AB852_07570"
     CDS             complement(3349..3762)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003966375.1"
                     /locus_tag="AB852_RS07720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_07570"
                     /product="anti-sigma regulatory factor"
                     /protein_id="WP_073784816.1"
                     /transl_table=11
                     /translation="MSQIAGEPGTQDFVEVRLPAAGAYLSVLRTATAGLAARLDFTLDE
                     IEDLRIAVDEACAILLQQAVPGSVLSCVFRLVDDSLEVTVSAPTTDGRAPERDTFAWTV
                     LSALAGKVDSSVADDKTVSISLYKQRGAGPGPA"
     misc_feature    3893..3906
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.6"
                     /tool="antismash"
     gene            complement(4146..4406)
                     /locus_tag="AB852_RS07725"
     CDS             complement(4146..4406)
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018571357.1"
                     /locus_tag="AB852_RS07725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="UBP-type zinc finger domain-containing protein"
                     /protein_id="WP_073784818.1"
                     /transl_table=11
                     /translation="MKQCTHISALPDPAPEPLSETCPGCLAAGTNPVQLRMCLSCGHVG
                     CCDSSPLRHATGHHEETGHPVMRTHEPGEDWRWCFVDCVIV"
     gene            4480..6078
                     /locus_tag="AB852_RS07730"
                     /old_locus_tag="AB852_07575"
     CDS             4480..6078
                     /GO_function="GO:0015385 - sodium:proton antiporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0006814 - sodium ion transport [Evidence
                     IEA]"
                     /GO_process="GO:0006885 - regulation of pH [Evidence IEA]"
                     /GO_process="GO:1902600 - proton transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016639610.1"
                     /locus_tag="AB852_RS07730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_07575"
                     /product="Na+/H+ antiporter"
                     /protein_id="WP_073784820.1"
                     /transl_table=11
                     /translation="MDALSVIGLIAASAAVAGLARRTPVPAPLLLVTAGLIAAYIPGVP
                     EFALDPHIVLPLLLPPLLHNAALESSYLDLRANIRPVALLSVGYVLFATVAVGWLAYLL
                     IPHLPLTAALVLGAVIAPPDAVAATAIARKVGLPSRITTILQGESLVNDATAITAFKVA
                     LAAAVGEGMSWAGGIQEFLVASVGGVAVGLILMVPLHWLRLHLKEAMLQNTLSLLIPFV
                     AYAAAEQVGASGVLAVVVVALYLGHRAWQVDFETRLQEAAVWRMVSFILESTVFALIGL
                     QLPLVLEGLGPVGYAQALWYAFALFVVVVAVRFVWSYPATYLPIWLSPRIKAREADTDW
                     RRPLVVSWAGMRGVVSLAIAFSIPLTTHDGDAFTARNLVLFLTFTTVIGTLVVQGLTLP
                     GLIRLLKLPGRDARSRTLAEAQAQNAASRAADERLDELLQDRRNDLPGPLVDRLRLTLE
                     RRRNAVWERLGQPNPETGESVDDTYRRLTREMIGAERDVFVRLRDARVIDDELMRTLLR
                     RLDLEEAAAYREEAD"
     gene            complement(6194..7075)
                     /locus_tag="AB852_RS07735"
                     /old_locus_tag="AB852_07580"
     CDS             complement(6194..7075)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006142329.1"
                     /locus_tag="AB852_RS07735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_07580"
                     /product="pyridoxal-phosphate dependent enzyme"
                     /protein_id="WP_073785614.1"
                     /sec_met_domain="PALP (E-value: 4.4e-19, bitscore: 65.6,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPPQVPTPLEPVEDPRFDARGITLSLKRDDLIHPHLVGNKWRKL
                     APNLTAAAGHPLVTFGGAYSNHLRATAAAGRLLGVATTGVVRGDELADRPRNPSLARCE
                     ADGMRLHFVDRSTYRRKDEPEIRAALLRDLGEEDAYLVPEGGSNALAVQGCAALGTELR
                     GHADVVAVACGTGGTLAGLAAGLGPDQRALGVSVLKGGFLTGETARLQDTAFGGPRGRW
                     SVTDRFHCGGYARVPAALEAFAADFEQRHGLAVERLYVAKTLWALTVLAEEGAFPAGTR
                     LTAVVTGAPEPY"
     gene            complement(8009..8245)
                     /locus_tag="AB852_RS07740"
                     /old_locus_tag="AB852_07585"
     CDS             complement(8009..8245)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008745667.1"
                     /locus_tag="AB852_RS07740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_07585"
                     /product="hypothetical protein"
                     /protein_id="WP_073784822.1"
                     /transl_table=11
                     /translation="MAGFLDRAKEQVQQGLNQGKQKLDEVQAQRAGADLLKKIGAAYYA
                     ERRGSGTPEATQRAVQELESHIAVHGDGVLRQH"
     misc_feature    complement(8508..8519)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     gene            8604..10010
                     /locus_tag="AB852_RS07745"
                     /old_locus_tag="AB852_07590"
     CDS             8604..10010
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136651.1"
                     /locus_tag="AB852_RS07745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_07590"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_073784824.1"
                     /transl_table=11
                     /translation="MSVGEEVRAEQAQPQQSLGTAAARNLATTTKSAPQMQEISSRWLL
                     RMLPWVNVQGGTYRVNRRLTYSVGDGRVTFVKTGDDVRVIPAELRELPVLRDYEDLEVL
                     GELAGRCEQREYAAGEVLTSFGNPSGEVFLLAHGRVEKIGTGPYGDDAVLEVLADGSHF
                     GDESLTDPDAIWEYTARAATATTVLVLPRAAVEQTGERSESLRAHLEGLRAIPEQRANK
                     YGERAIDLSAGHVGEAALPGTFVDYEASPREYELSVAQTVLRIHSRVADLYNQPMNQTE
                     HQLRLTVEALKERQEHEMINNKEFGLLNNCEYEQRIQPHDGAPGPDDLDELLSRRRGSK
                     LFLAHPRAIAAFGRECNRRGLVPESVEVAGNRIPTWRGVPIFPCNKIPVSDARTTSIIC
                     MRTGETEQGVVGLHQAGIPDEIEPSLSVRFMGISEQAIISYLVTTYYSAAVLVPDALGI
                     LENVEIGRWQ"
     gene            10001..11197
                     /locus_tag="AB852_RS07750"
                     /old_locus_tag="AB852_07595"
     CDS             10001..11197
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018571361.1"
                     /locus_tag="AB852_RS07750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_07595"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     polyprenyl transferase"
                     /protein_id="WP_245876684.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 8.7e-56, bitscore:
                     185.8, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVTSTGPEPGVGADTLSALPGQSLAGGRESVGTVTSSREGRPGS
                     GPVPAPAGPDDGGDTEAMALLEAARSDVDPELRRAVDTLPGQLRRIARYHFGWERADGT
                     PAAGNAGKAIRPALVLAAVRALGGRPKDAVRAAAAVEVIHNFTLLHDDVMDRDATRRHR
                     PTAWSVFGDADAILAGDALQALGYVMLAGDPHPGAARAAARLATCVVELCAGQQSDTAM
                     ERQAPGEVTLDGCLAMAEAKTGALLGCACAIGAVYAGAGEEEVAALDAFGREAGLAFQL
                     IDDVIGIWGDPRRTGKPAGADLLARKKSLPVVAALGSGTAAGAELALLYGVPADPSDAA
                     ALARTVRVVEAAGGRDWAQLQAGDRMSRAVQCLARAVGEPAAAGELLALAEFVTRRTV"
     misc_feature    11653..11669
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.11"
                     /tool="antismash"
     misc_feature    11758..11767
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     misc_feature    11917..11926
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     misc_feature    12003..12012
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            12160..12753
                     /locus_tag="AB852_RS07755"
                     /old_locus_tag="AB852_07600"
     CDS             12160..12753
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003998010.1"
                     /locus_tag="AB852_RS07755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_07600"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_073784826.1"
                     /transl_table=11
                     /translation="MAVVIRAAGAGDREAVVRLLDAAFHDDPVSNWVFPEEESFRRGHP
                     LLMGAFLDLVLEGGRVDLAEDGSAVALWLSVPEGAHDEDDDGPALLRQAIDPDNKRVEA
                     VGRLTSGIHPTHTAHEYLWMIAVDPARRGEGLGTALIAAALERCDRDGTAAYLEASSAR
                     SRDLYTRLGYTVLDPVLELPDGPTMWPMWREPRG"
     gene            12845..13546
                     /locus_tag="AB852_RS07760"
                     /old_locus_tag="AB852_07605"
     CDS             12845..13546
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015612587.1"
                     /locus_tag="AB852_RS07760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_07605"
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="WP_079184425.1"
                     /transl_table=11
                     /translation="MDVEVPVPGGGRTGRAAHYYGGPGFAAGVVDGLGVALLEPDADWL
                     PRLPREWTGRRIATTDLAAARRLTRPAFLKPPTAKTFPAAVYPDGRDLAPELPPDTPVQ
                     MSEVVRWAAEYRLFVLDGTVRTGSRYATHGLLDAAPLAADPRADAVSDFAARLLAGHAD
                     TLPSAVVLDVGLLAGDEPGWAVVEANMAWFSTCYAADPERCLDVVLRAAGPRDRIRDGD
                     RRFVVAGRGAP"
     gene            13593..14198
                     /locus_tag="AB852_RS07765"
                     /old_locus_tag="AB852_07610"
     CDS             13593..14198
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005478956.1"
                     /locus_tag="AB852_RS07765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_07610"
                     /product="response regulator transcription factor"
                     /protein_id="WP_073784830.1"
                     /transl_table=11
                     /translation="MIRVLVAEDLHVVRAGLVLLLDEAFDIEVVADVSSGDAVIPAALA
                     RRPDVAVLDIGMPGTDGLTTALRLRERLPDCRSLLLTAMDRPGHLRRALDAGLPGFLLK
                     SVAPERLLEAVRTVAGGGRMIDPALLDEAWAFGECPLTERETEILRLAGDGADAREIAV
                     GLSLSIGTVRNRLSDVIRKLHARTLVDAVRIAGRNGWT"
     gene            complement(14235..15437)
                     /locus_tag="AB852_RS07770"
                     /old_locus_tag="AB852_07615"
     CDS             complement(14235..15437)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF019350.4"
                     /locus_tag="AB852_RS07770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AB852_07615"
                     /product="histidine kinase"
                     /protein_id="WP_073784832.1"
                     /transl_table=11
                     /translation="MRDSPPWAAARRLGPRARDVSPRALLVSRLTLVALAAVTGIMFLH
                     MWTGLDGLDLDHRTTAVSVLTAVLLLITLLGQYARRHPHWRRMLLLVAQAALTYLPVLL
                     FREIWLSVLGLLLGASLASLPRPSGLIAAAMVTVSGPVVIFLLPVDNRTAVGVAARTLV
                     VGLVVYGIVRLASVAVQAHAARTQTARAAVQRERARMAQDLHDLLGAALSAIAVRGEAA
                     ARTTDDPAAARREFVALAELARQAHHDVRGVARDRVSLSLGRELASARAALEAAEVRVR
                     VTQDGPRVPAAVGTCFGAVLRECLSNVLRHSQARVCSITLRHGDGSAELTVENDGVPVR
                     PAPGAHDGTGLTSLAVRVTALGGSLTVSGPRAGGLFRVVARVPVPPDPEPRPAMHDART
                     G"
     misc_feature    16521..16535
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.73"
                     /tool="antismash"
     misc_feature    complement(17253..17265)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.45"
                     /tool="antismash"
     misc_feature    17598..17613
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.89"
                     /tool="antismash"
     misc_feature    complement(18954..18969)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.11"
                     /tool="antismash"
     misc_feature    complement(20613..20625)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 22.13"
                     /tool="antismash"
ORIGIN
        1 ggcgctggcc tgccgcgccc gattgcgagc ggcccgacgc ttcattgcgc ggcgctcgtc
       61 ctcgctgagg ccaccccaga cacccgagtc ctgaccggac tcgagcgccc actgcaggca
      121 ctgctccact acggggcagc gacggcagac ggccttggct tcctcgatct gcagcagcgc
      181 gggaccggtg ttgccgatgg ggaagaacag ctcggggtct tcctcgcggc aaacggcgtt
      241 gtgacgccag tccatggctg ctacctctct tggtgatact tcggattgct tgtgaatgtg
      301 aacgctttca cgaatccccc aacaagtgaa gggcctacac ccggaagccg ggggcggtcc
      361 attgttttga ggaggggttc gggctctctg tggggggcgg tggtgcggcc cgtcccgagc
      421 gccacataga gactcgcaaa cctgggctgc ggatacaacc ccttctggaa agtttttttt
      481 gattcctcgg tgtcgactag gtcacagccg tacttccatg gggtggaccc ttgcctaaac
      541 gttcgagtgc aaggactttt gccccttcca ctcacacaat cacacgcagt gcacggccta
      601 cgcctaggaa cgtcacgctc gttcgcagtc cgaggtggtc tccgtccatc tgcaagggca
      661 gtgggacctt cgaatgcaag gtgaactcgt tcaggtcgtg cagtgacacc gcgtgcttgc
      721 cctggggtcc ccgttcgggg gacgaagtga gcaattgtgt ggcataccgg gtcaccgcgg
      781 gggtggtgag ccgggtgagc ccgagcacat ccagtcccgt gtcgaacgac gcgcggggtg
      841 ccgcgtagag cgggcgattg cccagatagc tccacggggc cgtattgcag actatggaca
      901 gcagaagatc ctcgatcggt tcccggcccg gctgttccag ggtgatcgaa ccgtgccggc
      961 gctgttcacc cagaaattgc cggaccacct gccgcacgta aagcgcgtgg gtcgaccgct
     1021 ttcccgactc gcgctgctgt tcgacccgtc cgaccacccc ggcatcgaat ccgaggcccg
     1081 cgcagaaggt gaaccagcgg ccgggaatcg cctcgtcggc cgtcccgggc gtgcccttcg
     1141 ccatcccgag cccgacggtt cgctcggagc cccgttcgat cgcgtccagc agggcgcccg
     1201 tcgcctccac ggcgtcgttc ggcaggccca gcgcgcgggc gaacacattc gtggaaccgc
     1261 cggggaccac cgcgagccgg ggaccgcgct ccgggtccgg cccgtggtcc atcagaccgt
     1321 tgacgacctc gttgaccgtg ccgtcgccgc ccagcgccac caccaggtcg atctcgtcgc
     1381 cctcggcggc ctgccgggcg aggtcccggg cgtgcccgcg gtactcggtg gtgaccgctt
     1441 cgagcttcat ctcgctcgcc agggcgtgga tcagcacatc acgcgtacgc gcactggtgg
     1501 tcgtggccgc cgggttgact acgaggagtg cgcgcatgcc atgcagggta cccagcgcgc
     1561 ggcaccggac cccacctcgg gcccgccgcc ggaccctccg ccgcgcgccg gacggcccgc
     1621 cggcccggcc ttcgcgccgc gcgggctacc ctgctggggt gagtgctgaa gcgaagtccc
     1681 cgcggggcac ggaccccggc gggacccccg aaggaccccg cccgggacgg ctgaccgcgg
     1741 ccgcggccct gaccggattg gagggtgccg cgctcgtcgc cggcggcctg tacgtgagcg
     1801 tgcgcgggct gaccggggac ggcagcgccg gacaggcgct caccgcggga gtgacgctcg
     1861 tcgcgctcgc cgtgctgccg ctcgtcgccg cgaagggcct gctggcgcgg cgcggctgga
     1921 gccggggccc cgcgatcatg acccagatca tctcgctgcc cgtggcgtgg accctgctcc
     1981 aggccgacag catgctcatc cccggcggga tcgccctcgg ggtcgccgcc gtcaccaccc
     2041 tggtcctgct ggtcaacccc gccacgaccg tggccctgga catccgcggc cccggccgcg
     2101 ccgaccagta gcgacggcag cggacgcaca cacgcacgac cgacgcccgg gacccgaggg
     2161 tcccgggcgt ctcccgtccg tcacggccgg tcaccaccgg ccggtacggc tactcctcga
     2221 ccagcagctt ctcgcgcagc tgcgccaggg tcctggccag cagccgggag acatgcatct
     2281 gggagatgcc gacctcctgc gcgatctgcg actgggtcat gttgccgaag aaccgcagca
     2341 gcaggatgcg cttctcgcgc ggcggcagat cctccagcag cggcttgagg gactcgcggt
     2401 actcgacgcc ctccagcgcc tcgtcctccg agccgagggt gtcggccacg gccggtgact
     2461 cgtcgtccgt gtccggcacg tccagggaca gcgtggagta ggcgttcgcc gactccagcc
     2521 cctccaggac ctcctcctcg gagatcgcca gcttctcggc gagctcgtgc accgtggggg
     2581 agcggccgtg ctgctgggac agctcggccg tcgccgtggt cagcgagagc cgcagctcct
     2641 ggagccgccg cggaacgcgg accgcccagc ccttgtcgcg gaagtgacgc ttgatctccc
     2701 cgacgaccgt cggcgtggcg taggtggaga actccacccc ccgctccggg tcgaaccggt
     2761 ccacggactt gatcagcccg atcgtggcga cctgcgtcag atcgtccagc ggctcccccc
     2821 ggttgcggaa gcgccgtgca aggtgctcca cgagcgggag atgcagccgt acgagcttgt
     2881 tgcgcagctc cgcgtactcc gggctgccgt cgggcagggt gcgcagcgtg acgaacatcg
     2941 cccgtgccgc gctccggtcc tgctcgtgcc gggagcgctg cacttcccgg gcacccggtg
     3001 cgcccgcttc ccgctcggcg gcccgttcgt gctcgctcat tcttcccgcc ctcccccagc
     3061 tcccgctggg aggtgccccc ggtccgccgc cccggccgga ccgcgacgcg cgcccgtccg
     3121 tgtccccggg gccgtccgga tgtgcctgct ccaacacgtc ggtcgtgtcc ggcgacctcg
     3181 ccggccccgt cgggtcggcc gcttcccgga gggtgtcctc cgggtgcgac ctggcctgct
     3241 gctcggggat accgcccggc gccggacggc cgcttgggcc gcccggatca ccggcgggga
     3301 gacctggtgt gccgcttccc tcgtcccgca ccggcccgtc cccgtccctc acgccggccc
     3361 gggtcccgcg ccgcgctgtt tgtagaggct gatcgacacg gttttgtcgt ccgcgacgga
     3421 cgagtccacc ttccccgcga gagccgacag cacggtccag gcgaaggtgt cgcgctcggg
     3481 agcgcgaccg tccgtcgtcg gggccgagac cgtcacttcc agggagtcgt ccacgagccg
     3541 gaacacacag ctcagcaccg aaccgggcac ggcctgctgg agcaggatcg cgcacgcctc
     3601 gtcgacggcg atacggaggt cctcgatctc gtcgagggtg aagtccaaac gcgccgcgag
     3661 accggccgtc gccgtccgca gcaccgacag gtaggcaccc gcagccggca accggacttc
     3721 cacgaagtcc tgggtcccgg gctctcctgc gatctgggac accctcacct ccaaggtggt
     3781 acaagctctt cggggctccg ggggatcgtc cccccggaca acgcgctaga tgtttcagcg
     3841 gtgacgctat cgcgctgacg gcgtgagtgt cccagggacc ccgtcccttg ctgtcactca
     3901 tcgtaagcac atgggtacgc acagtggcta ggggtctgcg ggtaccgatg ggaacaccat
     3961 cctgcccccc gccgatccct ccgcgcgccg ctgtgacgta cccagcgtcc cggcacccga
     4021 accgtccccg tcaccgccgc acgctcgcgc ggcgccccgg cggaccccga ggtcagccac
     4081 cggcggatcg tttccgcact tgagcggcac gggctccgct cagccgcgga cgccggccgc
     4141 gcccgtcaca cgatcacgca gtcgacaaag caccatcgcc agtcctcacc gggttcatgc
     4201 gtgcgcatga ccggatgccc cgtctcctcg tgatggcccg tggcgtgtcg cagcggcgac
     4261 gagtcgcagc agcccacgtg cccgcacgac agacacatcc gcagctgcac cggattggtc
     4321 cccgcggcca ggcaaccggg gcacgtctcg ctcaacggct ccggcgcggg gtcgggaagc
     4381 gccgagatat gcgtgcactg cttcatgatt gccaggttac gtgcgtgcgc gggacccggc
     4441 agggcccggc gatccgcagc gccgggaagg gataccgcga tggacgcgtt gtcggtgatc
     4501 ggactgatcg cggcgagcgc ggccgtggcc gggctcgccc ggcgcacccc cgtacccgcg
     4561 ccgctgctgc tggtcaccgc cgggctgatc gccgcgtaca tccccggggt ccccgagttc
     4621 gccctcgacc cgcacatcgt gctgcccctg ctgctgccac cgctgctcca caacgcggcc
     4681 ctggagagct cgtacctgga cctgcgggcc aacatccgcc ccgtcgcact gctgtccgtc
     4741 ggctatgtgc tcttcgcgac cgtcgccgtg ggctggctgg cgtatctgct gatccctcat
     4801 ctgccgctga cggccgcgct ggtgctcggc gcggtgatcg cgccgcccga cgcggtggcc
     4861 gccacggcga tcgcccgcaa ggtgggactg ccctcccgga tcaccacgat cctccagggc
     4921 gaatccctcg tgaacgacgc caccgccatc accgccttca aggtcgccct cgccgccgcc
     4981 gtcggcgagg gcatgagctg ggccggcggc atccaggagt tccttgtcgc gtcggtcggg
     5041 ggagtggccg tcgggctgat cctgatggtc ccgctgcact ggctgcgcct ccacctcaag
     5101 gaggcgatgc tccagaacac cctctcgctg ctcatcccct tcgtcgccta cgccgccgcc
     5161 gaacaggtcg gcgcctccgg ggtgctcgcc gtggtcgtcg tcgccctcta cctcgggcac
     5221 cgggcctggc aggtcgactt cgagacccgg ctccaggagg ccgccgtgtg gcgcatggtc
     5281 tcgttcatcc tggagtccac cgtcttcgcg ctgatcggac tgcaactgcc gctcgtcctc
     5341 gaaggactcg ggccggtcgg ctacgcccag gcgctctggt acgccttcgc gttgttcgtg
     5401 gtcgtggtgg cggtgcggtt cgtctggtcc tacccggcca cctatctgcc gatctggctc
     5461 tcgccccgga tcaaggcccg cgaggcggac acggactggc ggcggcccct ggtggtgagc
     5521 tgggcgggga tgcggggcgt ggtgtcgctg gccatcgcct tctccatccc gctgaccacg
     5581 cacgacgggg acgcgttcac cgcccgcaac ctcgtcctgt tcctgacctt caccaccgtg
     5641 atcggcaccc tcgtggtgca gggcctcacc ctccccgggc tcatccggct gctgaagctg
     5701 ccgggccggg acgcgcggtc gcggaccctc gcggaggcgc aggcccagaa cgccgcctcc
     5761 cgcgccgccg acgaacgcct cgacgaactc ctccaggacc ggcgcaacga ccttcccggc
     5821 ccccttgtgg accgtctgcg gctcaccctg gagcgacggc gcaacgcggt ctgggaacgg
     5881 ctggggcaac ccaacccgga aaccggcgaa tccgtcgacg acacctatcg ccggctcacc
     5941 cgcgagatga tcggcgccga gcgggacgtc ttcgtgcggc tgcgggacgc gcgggtcatc
     6001 gacgacgagc tgatgcggac gctgctgcgc aggctcgacc tggaggaggc cgcggcctac
     6061 cgcgaggagg cggactgacc tccccggccc ggtcggtccc ccgccggtcg gccggttccc
     6121 cgcgggccgc gcggttcccg gcgaccgcgc ggttcccctc ccggcgcggt cgggtccggc
     6181 cctccgggtg cggtcagtac ggctcggggg cgcccgtgac gactgcggtc agccgtgtcc
     6241 cggcggggaa cgcgccctcc tcggcgagca ccgtcagcgc ccacagtgtc ttggcgacat
     6301 agagacgttc caccgcgagt ccgtgccgct gctcgaagtc cgccgcgaac gcttccagcg
     6361 cggcgggtac gcgggcatag ccgccgcagt ggaagcggtc ggtcaccgac cagcggcccc
     6421 ggggtccgcc gaaggccgtg tcctggagcc gggccgtctc cccggtgagg aagccgccct
     6481 tcagcacgga caccccgagc gcccgctgat cgggccccag cccggcggcg agtcccgcga
     6541 gcgtcccgcc cgtgccgcac gccacggcga ccacgtccgc gtggccgcgc agctccgtcc
     6601 ccagcgcggc gcagccctgt acggcgagcg cgttgctccc gccctccggg acgaggtacg
     6661 cgtcctcctc gccgagatcc cgcagcagcg ccgcgcgtat ctccggctcg tccttgcggc
     6721 ggtacgtcga tctgtcgacg aagtgcagcc gcatgccgtc cgcttcgcag cgggcgaggg
     6781 aggggttgcg ggggcggtcg gcgagctcgt cgccccggac gacgccggtc gtggcgacgc
     6841 cgaggagtcg gccggccgcg gcggtggccc tgaggtggtt cgagtacgcg ccgccgaagg
     6901 tcacgagggg gtggcctgcg gcggctgtga ggttcggggc gagcttgcgc catttgttgc
     6961 ccacgaggtg ggggtggatc aggtcgtccc gcttcaggga gagggtgatt ccccgggcgt
     7021 cgaaacgggg gtcttcgacg ggttccagcg gggtgggtac ctggggcggc ggcaagtggt
     7081 gcacccaccc attgtgatcc ccgcccgccc tgaccccggt ccgggtcccc gcccgggtca
     7141 cctcgggtgg gcgtacttgt tcctgtgccg tcgttcggtg gtttcgcgca gttccccgcg
     7201 ggtcgccttc gcttgcgctt ccgaggtctg tccggctggg cgcacttcgt tcctgtgccg
     7261 tcgctcggtg gggtgcgcag ttccccgcgc ccctttgggg cgccatctgc ttgttcttcg
     7321 ggtcggtgcc ggtcgggatt ctccgtcctc gatccgacac gctcggtaag tcgttccgtg
     7381 actcgactga agagcatcgg agtctgcgag cagagattcc cgcccagccc ctcccgtagc
     7441 cgggcgagtc cgcgaggagg gtggtttgaa ccccgaaccc ggttgatgca gcccgcaggc
     7501 tgacggcagc ctcagttggg cgcccccaaa ggggcgcggg gaactgcgca aaagacgagg
     7561 gcggacccgc acccgaagaa caacccgaag gaggcagcat ccaggggcgc ggggaactgc
     7621 gcgagcaacc acggaccacc cgcactcgaa cgggaaccgc aagaggcgcg acctcagggg
     7681 cgcggggaac tgcgcgaaag tgagggcgac ccgcacccga agagcgaccg taaggaggca
     7741 gcatccaggg gcgcggggaa ctgcgcaccc acggggaacc ggcacgcgaa caggtacgtc
     7801 caggtgtgga acctcagaag cgcgagcgaa ggcgacccgc ggggaactgc gcacccacgg
     7861 agtacccgca caggaacagg tacgtccagg tgtggaaccc cagaagcgcg agcgaaggcg
     7921 acccgcgggg aactgcgcac ccccggacaa cctgtgcggg aacaagtgcg cccagcacag
     7981 gaaaacctcg gggctccccg cacggggctc agtgctggcg caggacgccg tccccgtgga
     8041 ccgcgatgtg gctctccagc tcctggacgg cccgctgggt ggcctcgggc gtaccgctgc
     8101 cccggcgctc cgcgtagtac gccgcgccga tcttcttcag gaggtcggcc cccgcgcgct
     8161 gggcctggac ctcgtcaagc ttctgcttgc cctggttgag cccctgctgg acctgctcct
     8221 tggcccgatc gaggaaaccc gccatcgtga accacttccg ttcgtcaggt gccgcctgga
     8281 ccggcggcgt gctctttggt gcgcgcgttc gatgaacgtg cggggggatc ttggagttcc
     8341 cggccccttc cgttccgtca cacgggacag ctccctgtca cccgtgcggc ggacgtaggg
     8401 acatatccct ccgaactcgg atgttccagg accggcgtcc ccgtaaaccg tcggagcgca
     8461 cccgtgtaga aacggttcgt cacaattcgc tgctcacccg aacggcggcg ttcattcccg
     8521 ctcgtttgtg tgatggcacc ccgacggccc gtactgcaag gctcttcacc gcaggtcagt
     8581 gcaggtatcg ggagggcaaa tccatgtcgg taggcgaaga ggtccgcgca gagcaggcgc
     8641 agccgcagca gagtctcggc acagcggcgg cgcggaatct ggccaccacc accaagtcgg
     8701 caccgcagat gcaggagatc agctcgcgct ggctgctgcg gatgctgccg tgggtgaatg
     8761 tgcagggcgg tacgtaccgg gtgaaccgga ggctgaccta ttccgtcggg gacgggcgcg
     8821 tgacgttcgt caagaccggg gacgacgtcc gcgtcatccc cgccgagctg agggaactgc
     8881 cggtcctgcg ggactacgag gatctggagg tcctggggga actggccgga cgctgcgagc
     8941 agcgggagta cgcggcgggg gaggtgctga cgtcgttcgg caacccgtcc ggtgaggtgt
     9001 tcctgctcgc ccacggccgg gtcgagaaga tcggcaccgg tccgtacggg gacgacgcgg
     9061 tcctggaggt cctggcggac ggttcccact tcggggacga gtcgctgacc gatccggacg
     9121 cgatctggga gtacacggcc cgcgcggcga ccgcgaccac ggtcctggtg ctgccccggg
     9181 cggcggtcga gcagaccggt gagcggagcg agtcgctgcg ggcgcatctc gaagggctgc
     9241 gcgcgatccc cgagcagcgc gccaacaagt acggcgaacg tgcgatcgac ctctcggcgg
     9301 ggcatgtcgg ggaggcggcc ctgcccggca cgttcgtcga ctacgaggcg tccccacggg
     9361 agtacgagct gagcgtggcg cagaccgtgc tgcgtatcca ctcccgggtg gccgatctct
     9421 acaaccagcc catgaaccag accgagcacc agctccggct caccgtggag gcgctgaagg
     9481 agcgccagga gcacgagatg atcaacaaca aggagttcgg tctcctcaac aactgcgagt
     9541 acgagcagcg catccagccg cacgacgggg cgcccggccc cgacgacctg gacgaactgc
     9601 tgagccgcag gcgcgggtcg aagctgttcc tggcccatcc gcgggcgatc gccgcgttcg
     9661 ggcgggagtg caaccggcgc gggctggtcc ccgagtccgt cgaggtcgcg ggcaaccgca
     9721 tcccgacctg gcgcggggtg ccgatcttcc cgtgcaacaa gatcccggtc agcgacgccc
     9781 ggacgacatc catcatctgc atgcgtacgg gcgagaccga gcagggcgtc gtcgggctcc
     9841 accaggcggg catcccggac gagatcgagc ccagcctgtc ggtgcggttc atgggcatca
     9901 gcgagcaggc gatcatctcg tacctggtga cgacgtacta ctcggccgcg gtgctcgtcc
     9961 cggacgccct cggcatcctg gagaacgtcg agatcggccg ctggcagtga cgtccaccgg
    10021 tccggaaccc ggggtcggcg cggacaccct gtccgcgctc cccggccagt ccctcgccgg
    10081 agggcgggaa tccgtcggca ccgtgacgtc gtcgcgcgag ggacgaccgg ggtccgggcc
    10141 ggtcccggcc ccggccgggc cggacgacgg gggtgacacg gaggccatgg cgctgctcga
    10201 agcggcgcgg tccgacgtcg atcccgagct gcgccgtgcc gtcgacaccc tgccggggca
    10261 actgcgccgg atcgcccgct accacttcgg ctgggagcgc gcggacggca ccccggccgc
    10321 gggcaacgcg ggcaaggcca tccggcccgc gctcgtgctg gccgcggtac gggccctcgg
    10381 cgggcggccc aaggacgcgg tacgggccgc ggcggcggtg gaggtgatcc acaacttcac
    10441 gctgctgcac gacgatgtga tggaccgtga cgccacccgc cgccaccggc ccaccgcgtg
    10501 gagcgtgttc ggcgacgcgg acgcgatcct cgcgggggac gcgctccagg ccctcgggta
    10561 cgtcatgctc gccggtgatc cgcatcccgg ggcggcccgg gcggcggccc gcctcgccac
    10621 ctgtgtggtg gagctgtgcg cgggacagca gtccgacacg gcgatggaac ggcaggcgcc
    10681 gggcgaggtc acccttgacg gctgcctcgc catggccgag gccaagaccg gggcgctgct
    10741 cggctgcgcc tgtgcgatcg gcgcggtgta cgcgggggcg ggggaggagg aggtcgcggc
    10801 gctggacgcg ttcggccggg aggccgggct ggcgttccag ctgatcgacg acgtgatcgg
    10861 gatctggggt gatccccggc gtaccgggaa gccggccggg gccgatctcc tcgcccgcaa
    10921 gaagtccctg ccggtggtgg cggcgctggg ttccgggacg gcggcggggg ctgagctggc
    10981 gctgctgtac ggggtgcccg ccgatccctc cgacgcggcg gcgctcgcgc ggacggtgcg
    11041 ggtggtggag gcggcggggg gacgggactg ggcgcagctc caggccgggg accggatgtc
    11101 gcgggcggtg cagtgtcttg cgcgggcggt gggggagccc gcggctgcgg gggagctgct
    11161 ggcgctggcg gagttcgtga cccgccgcac ggtgtgaacc gcgggtcgcc ttcgcttgcg
    11221 ctttccaggt ctgtccggct gggcgcggtt gtccctgtgc cgtcgctcgg tggggtgcgc
    11281 agttccccgc gcccctttgg ggcgcgtccg gtcggttctt cgggtcggtg ccggtcggga
    11341 ttctccgtcc tcgatccgac acgctcggta cgacgtccgg tgacccgact gaagagcatc
    11401 ggagtctgcg ggcagagatt cccgcccacc ccctcccgta gtcgagcgac tgcgcgaggt
    11461 ggggggttgg accccaaccg ggctgatgcc ggcccgcacc ctgacggcag ccccagggga
    11521 cgcccccaaa ggcccgcggg gaactgcgcg agcaaccacg gaccacccgc acccgaacgg
    11581 gaaccgtaag aggcgcgacc tcaggggcgc ggggaactgc gcgaaaacga ggaccgaccc
    11641 gcacctgaag agtgaccgca aatggggcag catccagggg cgcggggaac tgcgcacccc
    11701 cgtccgaccc gcacaggaac aagcgcgtca cgccggacag acctcggaag cgcaagcgaa
    11761 ggcggcccgc ggggaactgc gcgaaaacga ggaccgggcc gcacccgaag agcgaccgca
    11821 agggggcagc atccaggggc gcggggaact gcgcacccga cgagcgacgg cacaggaaca
    11881 agcgcgtcac gccggacaga cctcggaagc gcaagcgaag gcggcccgcg gggaactgcg
    11941 cacccccgtc cggcccgcac aggaacaagt acgtccaggt ggggaacccc aggggcgcga
    12001 gcgaaggcgg cccgcgggga actgcgcacc cccgtccggc ccgcacagga acaagtacgt
    12061 ccaggtgggg aaccccggaa ccccggaagc gcgagcgaag gcgggtcgtt tagggtcaag
    12121 gggtccgggg tgcgggcttg ttgaggggtg gagggcggga tggctgtggt gatccgggct
    12181 gcgggggccg gcgaccggga agccgtggtg cggctgctgg acgccgcgtt ccacgacgac
    12241 cccgtgagca actgggtctt ccccgaggag gagtcgttcc gccggggcca cccgctgctg
    12301 atgggcgcct tcctggacct cgtcctggag ggtggccggg tcgacctcgc cgaggacggc
    12361 tccgccgtgg ccctgtggct gtcggtgccc gagggcgcgc acgacgagga cgacgacggc
    12421 ccggccctgc tgcggcaggc catcgacccg gacaacaagc gcgtcgaggc ggtgggccgc
    12481 ctcaccagcg gtatccaccc cacgcacacg gcccacgagt acctgtggat gatcgcggtc
    12541 gacccggccc gccggggcga gggactgggc acggccctga tcgccgcggc cttggagcgc
    12601 tgcgaccggg acggcaccgc cgcgtacctg gaggccagca gcgcccgcag ccgggacctg
    12661 tacacccggc tcgggtacac cgtcctcgac ccggtgctgg agctgccgga cggtccgacg
    12721 atgtggccca tgtggcggga accgcgcggt tagcgccgtg ccggggaccc gggcgctgtt
    12781 cgcggtggcg cagcggccga ccgtgacccg ggaactcctc gcggacacgg cgcgccgccg
    12841 gggcatggac gtcgaggtgc cggtgccggg cggtggacgg accgggcgcg ccgcgcacta
    12901 ctacggcggc cccggcttcg ccgccggtgt cgtggacggc ctgggcgtgg cgctcctcga
    12961 accggacgcc gactggctgc cccggttgcc gcgtgagtgg accgggcgcc ggatcgcgac
    13021 gaccgacctc gcggcggccc gccggctcac ccggcccgcg ttcctcaagc cgccgacggc
    13081 gaagacgttc cccgcggcgg tgtacccgga cgggcgggac ctcgcgccgg agctgccccc
    13141 ggacaccccc gtgcagatga gtgaagtggt gcgctgggcg gccgagtacc ggctgttcgt
    13201 gctggacggc acggtccgca ccggctcccg ttacgccacc cacggtctgc tggacgcggc
    13261 gccgctcgcg gcggaccccc gggcggacgc cgtctcggac ttcgccgccc ggctgctcgc
    13321 cggacacgcg gacacgctgc cgagcgcggt ggtgctggat gtggggctgc tggccgggga
    13381 cgagccgggc tgggccgtcg tggaggccaa catggcgtgg ttcagcacct gttacgcggc
    13441 ggacccggaa cgctgtctgg acgtggtcct gcgggcggcc ggaccacggg accggatacg
    13501 cgacggtgac cggcggttcg tcgtcgccgg acggggcgcc ccctgaccgc gaggcacttg
    13561 cgtgccccgg gggtctcacg gatgctgcca ggatgatcag agtgctggtg gccgaggatc
    13621 tgcacgtggt gcgcgccggg ctggtgctgc tgctcgacga ggcgttcgac atcgaggtcg
    13681 tggccgatgt gagcagcggt gacgcggtga tccccgccgc tctggcgcgg cgcccggacg
    13741 tcgccgtcct ggacatcggg atgccgggca cggacgggct gaccaccgcg ctgcggttgc
    13801 gtgagcggct gccggactgc cggtcgctgc tgctcaccgc gatggaccgg ccgggccatc
    13861 tgcggcgggc gctcgacgcg gggctgccgg ggttcctgct gaagtcggtg gcgcccgagc
    13921 ggctgctgga ggcggtgcgg acggtggccg ggggcggccg gatgatcgac ccggcgctgc
    13981 tggacgaggc gtgggcgttc ggggagtgtc cgctcaccga gcgggagacg gagatcctgc
    14041 ggctggcggg cgacggcgcg gacgcccggg agatcgccgt cgggctgtcc ctgagtatcg
    14101 gcacggtccg caaccggctg tcggacgtga tccgcaaact gcacgcccgc accctggtgg
    14161 acgcggtacg gatcgcgggg cgcaacggct ggacgtgagg cggggagcgc ggtccggtgg
    14221 gccgggtcgg cgggtcaccc ggtccgtgcg tcgtgcatgg ccgggcgggg ctccgggtcg
    14281 ggcgggacgg ggacccgggc gaccacccgg aacaggccgc ccgcccgggg gccggacacc
    14341 gtcagtgagc cgccgagggc cgtgacgcgg acggcgaggc tggtgagtcc ggtgccgtcg
    14401 tgcgctccgg gcgcgggccg tacgggtacg ccgtcgttct cgacggtgag ttcggcggag
    14461 ccgtccccgt ggcgcagtgt gatcgagcag acccgggcct ggctgtgccg cagcacattg
    14521 gacaggcact cgcgcagcac cgcgccgaag caggtgccga cggccgccgg gacccggggt
    14581 ccgtcctggg tgacgcgtac ccgtacctcg gcggcctcca gcgcggcgcg ggccgacgcc
    14641 agttcgcgtc cgagggagag gctgacccgg tcgcgggcca cgccgcggac gtcgtggtgc
    14701 gcctggcggg ccagttccgc gagggcaacg aactcccggc gggcggcggc ggggtcgtcg
    14761 gtggtccggg ccgccgcctc gccgcggacc gcgatggccg aaagtgccgc ccccagcaga
    14821 tcgtgcagat cctgggccat ccgggcgcgt tcccgctgga cggcggcccg cgcggtctgg
    14881 gtgcgggcgg cgtgcgcctg gacggcgacc gacgccagcc ggacgatgcc gtagacgacc
    14941 aggcccacca ccagggtccg cgcggccacg cccacggcgg tccggttgtc gacggggagc
    15001 aggaagatga ccacggggcc gctgaccgtc accatggccg ccgcgatcag tccggacggg
    15061 cggggcagcg acgcgaggct cgcgccgagc agcagtccga ggacgctcag ccagatctcc
    15121 cggaagagga gcacgggcag ataggtgagc gcggcctggg cgaccagcag cagcatccgc
    15181 cgccagtgcg gatgccgtcg cgcgtactgg ccgagcaggg tgatcagcag cagtacggcg
    15241 gtcagcacgc tgacggccgt ggtgcggtgg tccaggtcga ggccgtcgag tccggtccac
    15301 atgtgcagga acatgatgcc ggtgaccgcg gcgagcgcca cgagcgtcag ccgggagacc
    15361 agcagcgccc tcggggagac gtcccgggcc ctcggtccca gccggcgcgc ggcggcccac
    15421 ggcggagagt cacgcacgtc agacacccca gcccccctgg tccgtaacgc ggcgcatgtg
    15481 aacgtgcaca gtacaagtga agatctcacg ggcgcggcgt gaatatgtca attccggtcg
    15541 tcgcggggcc tcggttggat gtgctccaca ccctcaccga gagaggcacc ccgacgtgac
    15601 tgacacccca gggcccgccg acgagtggca gggctccgtg ctcgcgctcc agcggcgcag
    15661 acggatactg ccgcgtgtgg cggtcgccgt cgcggccgta ctgacggtcg aggcggccgt
    15721 gatcgtcgcc gccaccggcc aggccgtcgc cgtaccggcc gcggagcgcg aggccgccgc
    15781 ggaggctgag ccgaagccgg tgaggaaggc cggaccccgg caggcggagg acatcccgtc
    15841 cgcgcgggtc gcggcccggc tcgccggaca ccgggtggag gcgctcagcg aacggagtga
    15901 gacctcgacc acctgggcga acaaggacgg cagtctcacc accgaactgg ccgcggggcc
    15961 ggtccgcttc gagcgggacg ggaagtgggt cggcgtcgat gtggagctgg ccgggcagcc
    16021 ggacggcagt gtcgcgcccg ccgcgcatcc gaatggcttg aaactgtccg gtggcgaggg
    16081 ccgtccggcg tcgtcgctgc gggccgcgca gcggtccggg gcggtcgacc tggtcaccct
    16141 cggtcagggc ggcgagcagc tcaccctgcg ctggaagggc ggtctgcccg agccgcggct
    16201 gaagggcacc cgcgccgagt acgtcgacgc cgtgcccggc gcggacgtgg tggtcgaggc
    16261 gacgcgtacc ggcttcgagc agtacgtcga ggtgaaggag cggcccgcgg cgggctactc
    16321 gtacacgctg ccgctgacgg ccaaggggct gaaggccaag cagctggcgg acggcagtgt
    16381 gctgttcacc gaccgcagga acaagaagcg ggctgtcatg cccgcgccag tcatgtggga
    16441 cgcggcggtg gacaaggtct ccggcgagca cacccaccgc gcccgggtcg ggatgaaggt
    16501 cgtccagcgc gcggacggcg tggacctcgt catcaccccc gacgagaagt tcctcgccga
    16561 ccccgcgacg aagtaccccg tcaccgtcga cccgtcgacc tcgtcgctct ccagcgtctt
    16621 cgacacctac gtccagcagg gcgagaccgt cgactggtcc gccgacaccg aactggacct
    16681 cggcaacccc ggcaccaaca accccaatgg cacgccccgc accgcccgtt ccttcctcac
    16741 ctggaacacc tcgccggtcc gggacgcgct gatcaccgac gccaagctca gcctgtggaa
    16801 cttccactcc ggcaacacca cctgcgccgc gcagccctgg gaggtctggg ccaccggcgc
    16861 ggcctccacc tcgtcccgct ggaccgcaca gcccgcgtgg accgccaagc gcgccacctc
    16921 cacccagacc cgcggcaacc cgtcgtgcgc ggcccagccc gacggctgga tcgacgcgga
    16981 cgtcaccacc ctcgtccagg agtggtcctc cgccaaggcc acccgcggcc atatgggact
    17041 gcgggccacc agcgagacga ccgtcccgca gtggaagcgc gtcaactccg cgaacgccgc
    17101 cgcgaacccg ccgaagctgc gcgtcaccta caactaccgg ccgcgcaccg gcaccaagca
    17161 ggaggccgga ccgccgttct tctcctacgg ccccacctac ctggtcaaca cgaccacacc
    17221 gacgctgcgc gacaccttcg tcgacgccga cggtgacaag gtcaacggca ccttccagat
    17281 cttcgacaac gccaccgaca cccaggtcgg caacgtcatc gtctccaagt acacgccgtc
    17341 cggctcaccc gcgtccgtga ccgtccccgc cggggtcctc acccacggga agacgtacaa
    17401 gttccgcacc aacccgtacg acggcgcgca ctacaacacc ggctggtcgg cgtggaagac
    17461 gttcaccgtc gacaccgccg cgccctccgc gcccggcgcg atcacctcca ccgactaccc
    17521 ggccgggcag tgggtcaagg gcgagggcca gcccggcacc ttccgggtca ccccgccggc
    17581 cgccgaccac aactggctcg aatggtcgct cgacggtgtg acctggacca aggccgccac
    17641 cggcggcgcg tccgccgcga aggacctctc cgtcaccccg ccgaagaacg gcacccacac
    17701 cctccaggtg cgggccgtcg acaaggccga caacaagtcc gaggcccgcg agtacctctt
    17761 ccacgccgga cccggcggct tcgtccagcc cgccgacggc gaacgcaccg cacgccgcct
    17821 cccgctcgtc gccgaggcga aggcgggcac ctacgactcc gccgccttct cctggcgccg
    17881 ctccgaggcc gacccctgga cggcgatccc cgcaggtgac gtcaccgccg ccgggacccc
    17941 gctcaccggc tggccggtac cgctcgtcgc gggccgcaac gccccgctcg tgtggaacac
    18001 caccagcacc gtcgaccccg acggaaccgt ccagctcaag gccgacttca ccggccccgg
    18061 cgccgccacc agcagtaccg cgccgctgac cgtcgtcgtc gaccgcgacg ccgacggagc
    18121 cgcctccacc gaggtcggcc ccggctcggt gaacctgctc accggtgacc acaccctctc
    18181 cgagaccgac gcgtcgttct tcggcgtcag cgtgtcccgt accgcctcct cccggacccc
    18241 cgacgcgggg acccgccagg agggccaggc cgcgatcttc ggcaaggagt gggtggccgg
    18301 tacggccgcc gagggcaccg agtccgagta cagccatctg cgcaaggtct ccgacaccgc
    18361 cgtcagcgtc gtgtccgacg agggcgacgc gctccacttc accgccgacg ccgcccgcac
    18421 cggctgggtc tccgagcccg gcgccgagga cctgaccctg cgcggctccg tcaccggcac
    18481 cttcaccctc gccgatgccg aaggcgtggt gaccaccttc accaagcccg acccggcggc
    18541 caccacctgg caggtgtcca gcaccctcca ggacggcctc ggctcctcca ccaccaccgt
    18601 ggtctccgag accgtcaccg tcgcgggcaa gaagctggcc cgccccaagc ggatcatcgc
    18661 gcccacctcg gccgtgaccc ccgccgcctg cgagaccgac ccggccacca agggctgccg
    18721 ggtcctggag ttcgtctacg ccacggccac cacggccacc ggcacggtca ccgacgcgga
    18781 cttcggcgac ttcggcggcc agctcaagca gctgaggctc tgggccaccg cgcccggcgc
    18841 cgcgaacgcc accgccaccc ccgtcgccgg ataccgctac gactccgcgg gcaagctccg
    18901 ccagacctgg gacccccgca ccggccgcca ggcccagacc cagtactcgt accgggacgg
    18961 ccgggtgacc tggctggagc agcccggcga actcccgtac acctacacgt acggaaacgc
    19021 gggcggcgcc gccacctccg gcaacggcat gctgctgaag gccgcgcgcg agggcctgcg
    19081 acccggcacc gccgccaccg tcgagggcga ggccgtcacc agcctcgtct acggcgtccc
    19141 gctgaccggc accgccgccc cgcacgccat gggcagcgcc gccaccgccg gctggggcca
    19201 gctcgacacc cccagcgacg cgaccgccgt gttccccgcc gactccgtac cgtcctccca
    19261 cgacggcacc gcgctcaccg gcaacggcta cacccgggcc accgtccact acctcaacgc
    19321 ctccggccgc caggtgaaca cggccacccc cggcggccac ctcaccacca ccgagtacga
    19381 ccgccacggc aacaccgtcc gcgaactgac cgccgccaac cgggccctcg cgctcggcac
    19441 cacggacgcc cagaaggacc ggctcaccga cctcggcatc atcgccgcgc cctcggccga
    19501 acgagcccat ctgctgtcca ccacctccgt ccacaacgac aacggcaccc gcgaggaggc
    19561 cgagttcggc ccgctgcgcc gggtcgacct caccgaggac ctcaaggacg gcagcaccgt
    19621 cctgatcggc tccggcacct ccgtacccgc ccgcggctgg accgccaagc gctacgacga
    19681 gggccgcccc accgacggca ccgccaaggt caaggaccag gtcaccctgg agaccaaggg
    19741 cgcccagatc cgtgaccacg ccgccgtcca cgccgagaag cgcgtcacct cgacccgcta
    19801 cgactgggcc aagggcctgc ccacccacac cgtccaggac cccggcggac tggccctgac
    19861 caccgtcacc ggctacgact cccagggccg cgtcgtctcc caggcactgc ccggcggcac
    19921 cgccacgagc gccaacaccc ggctcaccga gtactggacg gccggcggca ccggccgctg
    19981 cgggggccgc cccgaatggg ccgacctgct gtgctggacc ggccccgccg gcgccgtcac
    20041 cggcggcggc tcccagccgt ccgcgctgcc cgacagcctc accgagtacg gcctcttcgg
    20101 ccagaccacc aaggtcaccg acacggcggg cggcaccacc cgcaccacgg ccaccgcgca
    20161 cgacgacgcc ggacgcccca ccacggtcac cgtcagcggc ggcctcggcc agcccgtccc
    20221 ggcgaccacc accggctacg atccggcgac cggcaaggtc accacgatca cctcgcccac
    20281 cgcgggcacg atcaccaagg cgtacgacaa gctcggccgc ctgctgtcct acaccgacgc
    20341 cgacggcggg gtgaccacca ccgagtacga cctgctcgac cgccccgtca aggagaccga
    20401 ctccgtcccc tcgaccgtca cccacaccta cgaccacgcg gccgaacccc ggggcctggc
    20461 cacccgcacc accgactcgg tcgcgggcgc cttcaccgcc acctacgacg cggacggctc
    20521 cgtcgccacc cagaaactgc ccggcggcca cagcctcacc gtcaccgagg acaccaccgg
    20581 cgccaccctg tcccgcgtct acacccggga cagcgacaac gtcaccctgt tcaccgacac
    20641 ggtcgccgca tccgtccacg gccaggtcac ccggcaccag ggctggtccg cgcagagcaa
    20701 ccagtacgac gccgtcggac gcctcgccgc cgtccaggac accgtcggcg aggtctgcac
    20761 acgccgcgcc tacggcttcg acacccgctc caaccgcacc tccctgacca ccgccaccgg
    20821 cgcgtccggc gccgcctgcc ccaccaccgg aggaaccacc accacccaca cctacgacag
    20881 cggcgaccgc ctcgtcgaca ccggctggac gtacgacgcc ctgggccgca ccaccgccct
    20941 gcccggcacc accctcggct accacgccaa cgacctcgcc caccggcaga ccaccggcaa
    21001 cagccgccag acctggcagc tcgaccccgc gctgcgcttc cgctcctgga ccgtcgagac
    21061 cggcggcggc accacctgga cgcggaccgc gagcaaggtc aaccactacg acggcgacgg
    21121 cgacaacccc cgctggaccg tggaggaccc ggcgaccggg gagatcaccc gcaacgtcca
    21181 ggcccccggc ggcgacc
//
