LOCUS       NZ_LWLE01000035        20978 bp    DNA     linear   CON 27-MAR-2024
DEFINITION  Streptomyces sp. TSRI0281 scaffold6, whole genome shotgun sequence.
ACCESSION   NZ_LWLE01000035
VERSION     NZ_LWLE01000035.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. TSRI0281
  ORGANISM  Streptomyces sp. TSRI0281
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 524139)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 524139)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra,H. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-APR-2016) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2016
            Assembly Method                   :: CLC NGS Cell v. 8.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905125.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:37:03
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,600
            CDSs (total)                      :: 8,518
            Genes (coding)                    :: 8,175
            CDSs (with protein)               :: 8,175
            Genes (RNA)                       :: 82
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 76
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 345
            CDSs (without protein)            :: 343
            Pseudo Genes (ambiguous residues) :: 0 of 345
            Pseudo Genes (frameshifted)       :: 151 of 345
            Pseudo Genes (incomplete)         :: 273 of 345
            Pseudo Genes (internal stop)      :: 33 of 345
            Pseudo Genes (multiple problems)  :: 102 of 345
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:13:17
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 317262
            Orig. end                         :: 338240
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LWLE01000035.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20978
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20978
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20978
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10978](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10978
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(279..292)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.13"
                     /tool="antismash"
     misc_feature    534..547
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.11"
                     /tool="antismash"
     misc_feature    complement(587..601)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 24.27"
                     /tool="antismash"
     regulatory      654..751
                     /bound_moiety="glycine"
                     /db_xref="RFAM:RF00504"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00504"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="glycine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            908..2023
                     /gene="gcvT"
                     /locus_tag="A6A29_RS36065"
                     /old_locus_tag="A6A29_18525"
     CDS             908..2023
                     /EC_number="2.1.2.10"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004047 - aminomethyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019464 - glycine decarboxylation via
                     glycine cleavage system [Evidence IEA]"
                     /codon_start=1
                     /gene="gcvT"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018509776.1"
                     /locus_tag="A6A29_RS36065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_18525"
                     /product="glycine cleavage system aminomethyltransferase
                     GcvT"
                     /protein_id="WP_073727076.1"
                     /transl_table=11
                     /translation="MSNAPRYTALDALHRSLGATMTDFAGWDMPLRYASERDEHNAVRT
                     RAGLFDLSHMGEITVTGPQAAAFLSFALVGNIATVGTGRARYTMIVGSDGGILDDLIVY
                     RLGESEYMVVANAGNAQIVLDALRDRVAGFDAEVRDDRDAYALLAVQGPQSPAIMKAVT
                     DADLDGLKYYAGLPGTVAGVPALIARTGYTGEDGFELFVAPEHAEQLWRALTEAGAPHG
                     LIPCGLSCRDTLRLEAGMPLYGHELTTALTPFDAGLGRVVKFEKEGDFVGREALTAAAE
                     RAGTAPPRKLVGLIAEGRRVPRAGFAVVADGQVIGEVTSGAPSPTLGKPIAMAYVDAAF
                     ATPGTGGVGVDIRGTHEPYEVVALPFYKREK"
     gene            2124..2501
                     /gene="gcvH"
                     /locus_tag="A6A29_RS36070"
                     /old_locus_tag="A6A29_18530"
     CDS             2124..2501
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0019464 - glycine decarboxylation via
                     glycine cleavage system [Evidence IEA]"
                     /codon_start=1
                     /gene="gcvH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010984206.1"
                     /locus_tag="A6A29_RS36070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_18530"
                     /product="glycine cleavage system protein GcvH"
                     /protein_id="WP_073727077.1"
                     /transl_table=11
                     /translation="MSNPHQLRYSKEHEWLSAVEDGVATIGITEYAANALGDVVYAQLP
                     DVGDTVTAGETCGELESTKSVSDLYSPVTGEIVAANQDVVDDPSLVNSAPFEGGWLFKV
                     RVAKEPGDLLSADEYTAFSGN"
     gene            2520..3779
                     /gene="glyA"
                     /locus_tag="A6A29_RS36075"
                     /old_locus_tag="A6A29_18535"
     CDS             2520..3779
                     /EC_number="2.1.2.1"
                     /GO_function="GO:0004372 - glycine hydroxymethyltransferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_function="GO:0070905 - serine binding [Evidence IEA]"
                     /GO_process="GO:0019264 - glycine biosynthetic process from
                     serine [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (75-368). E-value:
                     7.5e-14. Score: 43.5. Matches aSDomain:
                     nrpspksdomains_A6A29_RS36075_Aminotran_1_2.1"
                     /codon_start=1
                     /gene="glyA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007457161.1"
                     /locus_tag="A6A29_RS36075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_18535"
                     /product="serine hydroxymethyltransferase"
                     /protein_id="WP_073727078.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 5.7e-13, bitscore:
                     43.5, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLLNSSLHELDPDVAAAVDAELHRQQSTLEMIASENFAPVAVME
                     AQGSVLTNKYAEGYPGRRYYGGCEHVDVVEQIAIDRIKALFGAEAANVQPHSGAQANAA
                     AMFALLKPGDTIMGLSLAHGGHLTHGMKINFSGKLYNVIPYHVDDTGTVDMAEVERLAK
                     ESKPKLIVAGWSAYPRQLDFAAFRRIADEVGAYLMVDMAHFAGLVAAGLHPNPVPHAHV
                     VTTTTHKTLGGPRGGVILSTQELAKKINSAVFPGQQGGPLEHVIAAKAVSFKIAAGEEF
                     KERQQRTLDGARILAERLVRPDVTEVGVSVLSGGTDVHLVLVDLRDSELDGQQAEDRLH
                     EVGITVNRNAVPNDPRPPMVTSGLRIGTPALATRGFRDEDFTEVAEIIAAALKPSYDAA
                     DLKARVTALAEKFPLYPGLK"
     aSDomain        2745..3623
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A6A29_RS36075_Aminotran_1_2.1"
                     /evalue="7.50E-14"
                     /label="A6A29_RS36075_Aminotran_1_2.1"
                     /locus_tag="A6A29_RS36075"
                     /protein_end="368"
                     /protein_start="75"
                     /score="43.5"
                     /tool="antismash"
                     /translation="QIAIDRIKALFGAEAANVQPHSGAQANAAAMFALLKPGDTIMGLS
                     LAHGGHLTHGMKINFSGKLYNVIPYHVDDTGTVDMAEVERLAKESKPKLIVAGWSAYPR
                     QLDFAAFRRIADEVGAYLMVDMAHFAGLVAAGLHPNPVPHAHVVTTTTHKTLGGPRGGV
                     ILSTQELAKKINSAVFPGQQGGPLEHVIAAKAVSFKIAAGEEFKERQQRTLDGARILAE
                     RLVRPDVTEVGVSVLSGGTDVHLVLVDLRDSELDGQQAEDRLHEVGITVNRNAVPNDPR
                     PPMVTSGLRIGT"
     gene            3931..5313
                     /locus_tag="A6A29_RS36080"
                     /old_locus_tag="A6A29_18540"
     CDS             3931..5313
                     /EC_number="4.3.1.17"
                     /GO_function="GO:0003941 - L-serine ammonia-lyase activity
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0009063 - amino acid catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889625.1"
                     /locus_tag="A6A29_RS36080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_18540"
                     /product="L-serine ammonia-lyase"
                     /protein_id="WP_073727079.1"
                     /transl_table=11
                     /translation="MAISVFDLFSVGIGPSSSHTVGPMRAARMFARRLKNEGLLAHTAS
                     IRAELYGSLGATGHGHGTPKAVLLGLEGESPRTVDVEGADARVEQIRATGRINLLGMHE
                     IPFDADEQLVLHRRKALPYHANGMTIFAYDHEGALVLEKTYYSVGGGFVVDDDAVGEDR
                     IVLDDTVLKHPFRTGDELLRLSRDTGLSISSLMLENERAWRSEDEIRSGLLDIWRVMQA
                     CVSRGMSREGILPGGLKVRRRAANSARQLRAEGDSQAHAMEWITLYAMAVNEENAAGGR
                     VVTAPTNGAAGIIPAVLHYYMNFAAGGCTEAEKEDSVVRFLLAAGAIGMLFKENASISG
                     AEVGCQGEVGSACSMAAGALAEVLGGSPEQVENAAEIGMEHNLGLTCDPVGGLVQIPCI
                     ERNGMAAVKAVTAAKMALRGDGSHKVSLDKVIKTMKETGADMSVKYKETARGGLAVNII
                     EC"
     misc_feature    complement(5416..5430)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.37"
                     /tool="antismash"
     misc_feature    complement(5579..5592)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.47"
                     /tool="antismash"
     gene            5597..5869
                     /locus_tag="A6A29_RS36085"
                     /old_locus_tag="A6A29_18545"
     CDS             5597..5869
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003982871.1"
                     /locus_tag="A6A29_RS36085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_18545"
                     /product="hypothetical protein"
                     /protein_id="WP_073727080.1"
                     /transl_table=11
                     /translation="MVTSSAPGEGPIRPVSVSLHEGTIAALKARTGKRGMSAYVEALIQ
                     RQLERDLLRELIEDAEAEHGPVDQVAVEAKRAILRGDVADSADAA"
     gene            5866..6258
                     /locus_tag="A6A29_RS36090"
                     /old_locus_tag="A6A29_18550"
     CDS             5866..6258
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889623.1"
                     /locus_tag="A6A29_RS36090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_18550"
                     /product="PIN domain-containing protein"
                     /protein_id="WP_073727081.1"
                     /transl_table=11
                     /translation="MSGTLVLDCEGLSKLVRRSPEVTEWLAAAEDEDIRVVTSSVTLVE
                     ARDPKVNQARFDHAVSRVNIIPPTEAIARHASKLLATAGLHGHKYALDAIVAATALASP
                     APVTVLTSDPEDLLVLCRPGVRIVKV"
     gene            6955..8169
                     /locus_tag="A6A29_RS36095"
                     /old_locus_tag="A6A29_18555"
     CDS             6955..8169
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005321971.1"
                     /locus_tag="A6A29_RS36095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_18555"
                     /product="cytochrome P450"
                     /protein_id="WP_073727083.1"
                     /sec_met_domain="p450 (E-value: 5e-15, bitscore: 49.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVPFPIDPAGSDIPTEGARLRKAGAATLVTLPGGITAWAVTHHS
                     LLKQLLTDDRVSKDPRTHWPTWQRGEITPDSWLHTWLGVVNMFTAYGEDHRRLRKLVAP
                     AFTARRTEALSGEIESIAGRLLDTLETVPAGRGIDLRAGYAHPLPMQVMCSLFGIPEQL
                     RPRTAAVIARIFETDIGPEEAASTWREIQEVLTELVALKRPDPGDDMTSVLIAARDEDG
                     ARLSEEELLHTLWLVISAGFETTVNLIGNAVHALLSHPEQLRLVTAGEASWSDVVEETL
                     RWAPSVASLPLRFAVDDIPLPDGRTIARGEAILPAYAAAGRDPDQHGDDADDFDITRPA
                     HGHLAFGHGVHMCLGAPLARLEARIALPALFARFPGLALAGEPRDLVPMESFISNGFRA
                     LPVTL"
     gene            complement(8215..9309)
                     /locus_tag="A6A29_RS36100"
                     /old_locus_tag="A6A29_18560"
     CDS             complement(8215..9309)
                     /EC_number="2.5.1.54"
                     /GO_function="GO:0003849 - 3-deoxy-7-phosphoheptulonate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF009395.0"
                     /locus_tag="A6A29_RS36100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_18560"
                     /product="3-deoxy-7-phosphoheptulonate synthase"
                     /protein_id="WP_073727085.1"
                     /transl_table=11
                     /translation="MTTPTSGPLRTNDLRVTGFQPLIAPSVLLGDLPLGPTRAALVQDS
                     RRAVEDVLTGADDRLLLVVGPCSVHDPAAARDYARRLAAAVAPLHEDLCVVMRVYFEKP
                     RTTLGWKGLINDPHLDGTHDVQHGLRIARQVLLDVLDTGLPVGCEFLEPTSPQYIADAV
                     TWGAIGARTPESQVHRQLASGLSMPVGFKNATDGAVQPAVDGCRAAAGDHVFFGVDEQG
                     NGSIVSTSGNPDCHVILRGGRGGPNYGPEDIRDALKLLAGAGMPEQLVIDASHANSGKD
                     HHRQAEVVGEIADRIAGGEEGIAGLMVESFLREGRQEPGPLDTLTYGQSVTDACIGWER
                     TEELLGELASAVRRRRAARRTSAA"
     misc_feature    complement(9379..9399)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.12"
                     /tool="antismash"
     misc_feature    complement(9741..9754)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.49"
                     /tool="antismash"
     gene            10001..10978
                     /locus_tag="A6A29_RS36105"
                     /old_locus_tag="A6A29_18565"
     CDS             10001..10978
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0046246 - terpene biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018492272.1"
                     /locus_tag="A6A29_RS36105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_18565"
                     /product="terpene synthase family protein"
                     /protein_id="WP_073727087.1"
                     /sec_met_domain="T1TS (E-value: 6.2e-67, bitscore: 221.6,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPFESTGCNPGIAETRKAAWEWAESHGLFLSPPARKKMIRTRPEL
                     WISLIFPRASQRHLDLFCQWLFWAFLVDDEFDDGPAGRDPRMCEEAIARLVDVFDGAVP
                     VGRMEHALDGLRERTCRDRSPRWVRQFRRDTVAWLWTYYAEAVERAAGQVPSRADFVKH
                     RRDSVAMQPFLCLHEITAGIDLPDSARSLPAYIALRNAVTDHSGLCNDICSFEKEAALG
                     YEHNAVRLIQRDRGTSLQEAVDEAGIQLARIAERVQRAEKELAEEIDAADIGGGTRAAL
                     ERCVQDYRGLVRGDFDYHARAERYTRPDLVELDERDSLSRYFAA"
     gene            11290..13596
                     /locus_tag="A6A29_RS36110"
                     /old_locus_tag="A6A29_18570"
     CDS             11290..13596
                     /GO_function="GO:0008745 - N-acetylmuramoyl-L-alanine
                     amidase activity [Evidence IEA]"
                     /GO_process="GO:0009253 - peptidoglycan catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012378967.1"
                     /locus_tag="A6A29_RS36110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_18570"
                     /product="peptidoglycan recognition protein"
                     /protein_id="WP_073727089.1"
                     /transl_table=11
                     /translation="MRSKRRVWATAAVATAAVAGVLVVQGVTGTPTTGEDPDAKSAPAQ
                     ADVRKTALKVSEDGGSASLRQRSTEPFSMLGVTWTDPAAKVSGEVEARTRSAATGSWTG
                     WLPLDTEIDGRTEAGRPGVRGTTEPRWVGPSNGVEVRVTAGDGTSAGLPKGLRLDTVDP
                     GGSTSPAAEPAAYVAADTAPVEPAEDPTATEEPAPTQTPDTPPSPDPSPADTTGPDPSA
                     TTETPRTPSSDPDPILTSPAPSQPPSVTAEPSATLPPAPPSTVPQPPVVPRAGWGADES
                     LNNESPDYMSSVKAVFVHHTAQTNSYSCADSPAIVRGLLAFHVKSNGWKDLGYNFLVDT
                     CGKIFEGRKGGVDRAVQGAHTYGFNRDTAGIAVIGMYTDTKAASAATASVARIAAWKLG
                     QYGGDPAGTVPLTAGAAGNNYAGTKFTAGKKYSFQRISGHRDGFNTQCPGGKLYGQLSA
                     IRGLAAGPVTGLTIKSVTGASASGSTYYTTSDITVGWAASTPAAFITTYDLLVDGKSVA
                     TTKGSVTSAGATLAAGSHKVQVRATHQSGRTSLSATATVVADRTPPAFPARPSLSLRTG
                     TVSTTAVPLTLKWKATDAASLKEVRLTTPTAKTYGPTTVSASHTAKSGVATAWRMTAYD
                     RAGNTAGASVTGTPVILKESSAKKSGSWSTKSSSHYLGGKSYASGTKNAALTWTFTGRS
                     VAWVVSRASTSGIAYVYVDGVKVATVDLKSSSTKYRDAIWTKSWSSSAKHTVKIVVAGT
                     KGRPTVTTDGLVHLT"
     gene            complement(13589..14941)
                     /locus_tag="A6A29_RS36115"
                     /old_locus_tag="A6A29_18575"
     CDS             complement(13589..14941)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018487109.1"
                     /locus_tag="A6A29_RS36115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_18575"
                     /product="PucR family transcriptional regulator"
                     /protein_id="WP_079183164.1"
                     /transl_table=11
                     /translation="MASAKVPQGPQSPQSPPSSPTSQGPLSGGGEDIGLRHDLAAALLP
                     ELDELTRRVVDDIHAHSGTYAAQNLVSREDLWRICRDNLLSALEDFGGLPPTGGDFEHA
                     ARETGRRRAEQNLPLDTVLQAYRRGGRVMWQVMAEYLRAGTGRREPGPGHREPGTADRR
                     DVELDVAGAVWETIDRYSLVMAESYRLTQLEMQGRQDTRRVALFEALLDGRGSDPAVAS
                     AAAAALGVPLHDRYVIVVAAQDPAAPPNPAPVLDEHGLWSFWRPRSGRYAGIVRLAAGE
                     SGMLLELLRGRTGATAGVSPEFDRLDGAGRALRLAEQTLRTLPAKSGEAAAFDDRLTEV
                     LLTGRHEIAARIVSRYLGPVLDTAAERDALLDTLRIWLDHGCSAARAAELLYCHRNTVL
                     NRIGRVAELTGRSAESGEDRLGWALALRALPLSGTGDEPAPDDDYWDAAPT"
     misc_feature    15075..15092
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.13"
                     /tool="antismash"
     misc_feature    15101..15111
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            15105..16598
                     /locus_tag="A6A29_RS36120"
                     /old_locus_tag="A6A29_18580"
     CDS             15105..16598
                     /NRPS_PKS="Domain: AMP-binding (10-401). E-value: 7.4e-110.
                     Score: 359.3. Matches aSDomain:
                     nrpspksdomains_A6A29_RS36120_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018487108.1"
                     /locus_tag="A6A29_RS36120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_18580"
                     /product="long-chain fatty acid--CoA ligase"
                     /protein_id="WP_073727091.1"
                     /sec_met_domain="AMP-binding (E-value: 5.6e-113, bitscore:
                     372.3, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLSVASVLGESARRYPGRTAVVDGEVRLTYAELWARSLRCAGAL
                     RAAGVRPGDRVAVLLPNSAGFLYAYYGALAAGATVVPVHALLVADEVAYVLRHSRSVAL
                     ISAGPLWPVAEEAARAAGVRALNGAPDGEPLTAAEPAEAAGTAVILYTSGTTGRPKGAR
                     LTHLNIVMNASVITADLLDMGPDDVVLGCLPLFHSYGQTCAMNATLRAGATLVLMPRFT
                     GAAALTALAAESVSIFMGVPTMYHALVEAAALSGEAARGLTLRAAVSGGAALPVAVLER
                     FEAAFSTQVLEGYGLTETSPAATFNQPHLGRRPGTVGHPVWGVEIGIADAAVDESVRLL
                     ADGEIGEVVVRGHCVFAGYLDDPEATAAAIVDGWFRTGDLGVRDADGFLSIVDRKKDLI
                     IRGGFNIYPREVEEILVRHPAVGEVAVIGVPDDARGEEICAVVVVRPDAEPVTGDELIA
                     WSKERLGRHKYPRIVRFTERLPLGPTGKVLKRALTATTS"
     aSDomain        15135..16307
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A6A29_RS36120_AMP-binding.1"
                     /evalue="7.40E-110"
                     /label="A6A29_RS36120_AMP-binding.1"
                     /locus_tag="A6A29_RS36120"
                     /protein_end="401"
                     /protein_start="10"
                     /score="359.3"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="ESARRYPGRTAVVDGEVRLTYAELWARSLRCAGALRAAGVRPGDR
                     VAVLLPNSAGFLYAYYGALAAGATVVPVHALLVADEVAYVLRHSRSVALISAGPLWPVA
                     EEAARAAGVRALNGAPDGEPLTAAEPAEAAGTAVILYTSGTTGRPKGARLTHLNIVMNA
                     SVITADLLDMGPDDVVLGCLPLFHSYGQTCAMNATLRAGATLVLMPRFTGAAALTALAA
                     ESVSIFMGVPTMYHALVEAAALSGEAARGLTLRAAVSGGAALPVAVLERFEAAFSTQVL
                     EGYGLTETSPAATFNQPHLGRRPGTVGHPVWGVEIGIADAAVDESVRLLADGEIGEVVV
                     RGHCVFAGYLDDPEATAAAIVDGWFRTGDLGVRDADGFLSIVDRKKDLIIR"
     CDS_motif       15543..15602
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A6A29_RS36120_0001"
                     /evalue="1.90E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="A6A29_RS36120"
                     /protein_end="166"
                     /protein_start="146"
                     /score="23.5"
                     /tool="antismash"
                     /translation="AVILYTSGTTGRPKGARLTH"
     CDS_motif       16128..16211
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A6A29_RS36120_0002"
                     /evalue="1.30E-08"
                     /label="NRPS-A_a6"
                     /locus_tag="A6A29_RS36120"
                     /protein_end="369"
                     /protein_start="341"
                     /score="27.1"
                     /tool="antismash"
                     /translation="DGEIGEVVVRGHCVFAGYLDDPEATAAA"
     CDS_motif       16278..16340
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A6A29_RS36120_0003"
                     /evalue="4.20E-03"
                     /label="NRPS-A_a8"
                     /locus_tag="A6A29_RS36120"
                     /protein_end="412"
                     /protein_start="391"
                     /score="10.0"
                     /tool="antismash"
                     /translation="VDRKKDLIIRGGFNIYPREVE"
     gene            16846..18264
                     /locus_tag="A6A29_RS36125"
                     /old_locus_tag="A6A29_18585"
     CDS             16846..18264
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015486 -
                     glycoside-pentoside-hexuronide:cation symporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006812 - monoatomic cation transport
                     [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR00792.1"
                     /locus_tag="A6A29_RS36125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_18585"
                     /product="glycoside-pentoside-hexuronide (GPH):cation
                     symporter"
                     /protein_id="WP_073727093.1"
                     /transl_table=11
                     /translation="MTVPVPVRPPTTAPAPPAASQRPSVKEKLSFFAGNFGNILLSTTI
                     SSFLLLYLTDVLGIAAAAVGTLLLVVRIIDSLVDPFVGYAVDHLPATGRGRFRTYLLIG
                     GVLGGLSFAALFLAPALLPGPLVVAWIVYLLWGIAFPMMDIPLNSLLPVMTSDQKQRGS
                     LAAIKGFTYLFGGMLVIAVTLPVVGMFSSERTGWMLFCAAVAVLAVVCTTTAALGVRER
                     VRPTRTDKYGPRDLLRIFSGGRAAGVLLTAKVSTSAASAATLATMPFYFLYNVGDKGLV
                     TVAALVMMVPMAGGSVLAPALAARIGGKPVYAGALTVAAAGNATLFFMPYDTVPALMCC
                     LAVAGFGIGAAVTLNYVLLAELTDYVEWRHGHRAEGALASLASFAAKAGGGLGGAATAY
                     CLGLFGYVPGADQTQRAMDGIRYAQAGVPLALILIGGGVFLAYPITRRVSVTITEELTA
                     RRATASAQGTSDDE"
     gene            18257..20713
                     /locus_tag="A6A29_RS36130"
                     /old_locus_tag="A6A29_18590"
     CDS             18257..20713
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF036578.4"
                     /locus_tag="A6A29_RS36130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_18590"
                     /product="family 78 glycoside hydrolase catalytic domain"
                     /protein_id="WP_073727095.1"
                     /transl_table=11
                     /translation="MSDPTWGDWHGQWIWGEERGITPPGPGSMLGAPDPEVYDRRMMFR
                     RDFELSRVPASAPYRITSDSRHVLYINGVEAARGPVRHGPRMLHYDTGDAAPLLLPGRN
                     SIAVLVRHYGHAVPWWEPSPWTFELGGGALVAELRLTEDRWIATDSSWSCRPAGAWTPQ
                     RPHSQLVTQTPESLDARLLDPAWTRAVPGGPTPDRPARVLSTRAVVGPKGGTRPDSEPY
                     GALLPRPLPPLTDTVRGAESLRTAPLPGPLPPDPRQALAEALRATGDAAPATADATHPL
                     GAAPVLLLVDFGRVVAGHLRFSCTAESGTEISGALVELPTAAALDAANTFHYIARGHED
                     TFETSDPVGGRYALLVATGTGSLRLGPVQVRERLRPRPAGPYFSCDDAELNEIHRVGLR
                     TVDLTAQDAYLDCPTREQRAWTGDSVVHQAVDLVTNPDWSLARWSPQLAAQPRSDGMLR
                     MVAAGDFARDPIPTIPDWSLHWVRSVHQLYRCTGDRELVARLLATAEGVLRWFLPFRRP
                     DGLLHRVSGWVLIDWSPVQVTGASAALNALWARGLADFAEMADWLGDAGRARWAREAHQ
                     GVVTGFEAFWDADRGAYRDNLDGGRLGTSVSEHTHAAAVCGHLVPDQRLGAVRELLLDR
                     AAMFTRSPMRHRGSDAGGPLTSDPVSDREGPDWDTESLVVGAQPFFRYVVHDALALLGA
                     ADRIEGLCHDWTALLESGGSAFRECWEGGSYCHGWSATPSRDLLVHTLGVTPAEPGYLR
                     VRVAPRLGGLSWARGAVPTPGGLVQVDATPERVRIESPVPVEVLHPDGSLTHHPYGTSS
                     IDLRKG"
ORIGIN
        1 cttcgcgcgc cacttcgggc gtgacatcga gcaggacgag gtggaggatg cggccccggc
       61 gcctggcgtg ccgggcgagc cagcgacgta cccacgcctg cgtaccgcag tcgtgcacga
      121 ccaccgacgc gccggagcgc agcgcccgcc acagcccgag atagtgggcc gcccggacca
      181 gcgggcggta gagggcgtac gggagtaagc ggggcagcgc accggcccag gtgtcccggg
      241 tgtcctggga atcgatggcg cggtccgtca cggcccgctt gatcagtgtc gactttccgc
      301 tgccgggcag cccggagacc accaccagat caccctcccc gaagtccagg ctgtgcgggc
      361 ttcgcccggc ccggtcccgc agatcacgca ccaccggcgc gtgtgtgccc agcatttccc
      421 gggcgggtgc gcccggctgc gcgggcatcg cgccgtgcgc gacccccgcg gtcgtcgcgt
      481 accgctgcaa cgtcatcgcc ctccccctgt cgggtcaccc acacctgccc aagaagtgta
      541 aagaaaaggt aatgcggcac aactgggccc gccgaccaag tcggtggggg ccggacgccc
      601 cactctcccg cacgacatgc gatgatgacc ccgccaactg cataccggcc gtttgaatcc
      661 gcgcgggaga gttccggcca ctgtgtgtgc cgggcgccga aggagcaagt tcctcccttg
      721 aatctctcag gccccgtacc gcgtggatga ggcagatctg aaaagcgagc cgcccggcgg
      781 ctccacccaa ggtgcaagcc gaacccggcg agggctgacc ccttcagggc ctttcggcga
      841 acctctcagg ttccgatgac agatggggag ggatcgtcct ctgtcgtcat gccctggagc
      901 cgaatccatg agcaatgccc cccgttacac agccctcgac gccctgcacc gttcgctggg
      961 cgcgaccatg accgacttcg cgggctggga catgccgctg cggtacgcca gtgagcgcga
     1021 cgagcacaac gccgtacgca cccgggccgg tctcttcgac ctgtcgcaca tgggcgagat
     1081 cacggtcacc gggccgcagg ccgccgcctt cctgagcttc gcgctggtcg gcaacatcgc
     1141 gaccgtcggc accggccgcg cccgctacac gatgatcgtc gggagcgacg gcggcatcct
     1201 ggacgacctg atcgtctacc gcctgggcga gagcgagtac atggtcgtcg ccaacgcggg
     1261 caacgcccag atcgtgctgg acgcgctgcg ggaccgggtg gccggcttcg acgccgaggt
     1321 gcgcgacgac cgggacgcgt acgcgctgct cgccgtccag ggcccgcagt cgcccgccat
     1381 catgaaggcc gtcacggacg ccgacctgga tggcctgaag tactacgcgg gtctgcccgg
     1441 cacggtcgcc ggggtgcccg cgctcatcgc ccgtacgggc tacaccggcg aggacggctt
     1501 cgaactgttc gtcgcccccg agcacgccga gcagctgtgg cgggcgctca ccgaggccgg
     1561 cgccccgcac ggcctgatcc cctgcgggct ctcctgccgc gacacgctgc gcctggaggc
     1621 gggcatgccg ctgtacgggc acgagctgac gaccgcgctg accccgttcg acgcgggtct
     1681 gggccgggtc gtgaagttcg agaaggaggg cgacttcgtc gggcgcgagg ctctcacggc
     1741 cgccgcggag cgcgccggga ccgccccgcc gcgcaagctc gtcggcctga tcgccgaggg
     1801 ccgccgggtc ccccgcgccg gtttcgcggt cgtcgccgac ggccaggtga tcggcgaggt
     1861 cacctccggc gccccgtcgc ccaccctggg caagccgatc gccatggcgt acgtggacgc
     1921 ggccttcgcc acgcccggca ccgggggcgt cggcgtggac atccggggca cgcacgagcc
     1981 ctacgaggtc gtcgcgctgc ccttctacaa gcgcgagaag tgacatccgg ggcattccac
     2041 cgccccggaa gtgacgcatt cccgtctcac accgtaagac caccgttcat cagcactccc
     2101 ccgcgtacag gagaattcag gtcatgagca acccccatca gctgcggtac agcaaggagc
     2161 acgagtggct gtcggccgtc gaggacggcg tggccacgat cggtatcacc gagtacgcgg
     2221 ccaacgcgct cggtgacgtc gtctacgccc agctccccga tgtcggcgac accgtgaccg
     2281 cgggcgagac ctgcggtgag ctggagtcga ccaagtcggt cagcgacctg tactccccgg
     2341 tcacgggtga gatcgtcgcg gcgaaccagg acgtcgtgga cgacccgtcg ctggtgaact
     2401 ccgctccctt cgagggcggc tggctgttca aggtacgtgt ggccaaggag ccgggcgacc
     2461 tgctctccgc agacgagtac accgcgttct ccggcaactg agaccctagg gaacccctga
     2521 tgtcgcttct caactcctcc ctccacgagc tggacccgga cgtcgccgcc gccgtcgacg
     2581 ccgagctcca ccgtcagcag tccaccctcg aaatgatcgc gtcggagaac ttcgctccgg
     2641 tcgccgtcat ggaggcccag ggctccgttc tcaccaacaa gtacgccgag ggctaccccg
     2701 gccgccgcta ctacggtggc tgtgagcacg tcgatgtggt cgagcagatc gcgatcgacc
     2761 ggatcaaggc cctgttcggc gccgaggccg cgaacgtcca gccgcactcc ggtgcgcagg
     2821 cgaacgccgc cgcgatgttc gcgctgctga agccgggcga cacgatcatg ggcctgagcc
     2881 tggcccacgg cggtcacctg acccacggca tgaagatcaa cttctccggc aagctctaca
     2941 acgtgatccc gtaccacgtc gacgacaccg gcaccgtgga catggccgag gtcgagcgcc
     3001 tggccaagga gtccaagccg aagctgatcg tcgcgggctg gtccgcctac ccccgtcagc
     3061 tcgacttcgc cgccttccgc cgcatcgcgg acgaggtcgg cgcgtacctc atggtcgaca
     3121 tggcgcactt cgccggcctg gtggccgcgg gtctgcaccc caacccggtg ccgcacgccc
     3181 acgtcgtcac gaccaccacg cacaagaccc tcggcggtcc gcgcggtggc gtcatcctgt
     3241 cgacgcagga gctcgccaag aagatcaact cggcggtctt ccccggtcag cagggtggcc
     3301 cgctggagca cgtgatcgcg gccaaggcgg tctcgttcaa gatcgcggcg ggcgaggagt
     3361 tcaaggagcg ccagcagcgc accctggacg gcgcccgcat cctcgccgag cgtctggtgc
     3421 ggccggacgt caccgaggtc ggtgtctccg tcctgtccgg cggcacggac gtgcacctgg
     3481 tcctcgtcga cctgcgcgac tccgagctgg acggccagca ggccgaggac cgtctccacg
     3541 aggtcggcat cacggtcaac cggaacgccg tcccgaacga cccgcggcct ccgatggtca
     3601 cctcgggcct gcggatcggt acgccggccc tggcgacccg cggtttccgc gacgaggact
     3661 tcaccgaggt ggcggagatc atcgccgccg ccctgaagcc gtcgtacgac gccgcggacc
     3721 tcaaggcgcg cgtcaccgca ctcgccgaga agttcccgct gtaccccggt ctgaagtagt
     3781 ccggcaccag tcatcacgtt tcgggcgggg caccgcgcac actggacagt gagcgcggtg
     3841 cccccaccct tgtcctcgct cttcgggccc ccggcccgta ccgcaccacc cggcggacaa
     3901 cggcgtccac caacccttag gagtcatccc gtggccattt cggtcttcga cctgttctcg
     3961 gtcggcatcg gcccgtccag ctcccacacg gtgggcccca tgcgggccgc ccggatgttc
     4021 gcgcgccgcc tgaagaacga gggcctgctg gcccacaccg cttcgatacg ggcggagctg
     4081 tacggctccc tcggcgcgac cggccacggc cacggcacgc ccaaggccgt gctgctcggc
     4141 ctggagggcg agtcgccccg caccgtcgac gtggagggcg ccgacgcccg cgtcgagcag
     4201 atccgcgcca ccggccggat caatctgctc ggcatgcacg agatcccctt cgacgccgac
     4261 gagcagctgg tcctgcaccg ccgcaaggcc ctgccgtacc acgccaacgg catgacgatc
     4321 ttcgcgtacg accacgaggg cgccctggtc ctggagaaga cgtactactc ggtcggcggc
     4381 ggcttcgtcg tggacgacga cgcggtgggc gaggaccgca tcgtcctgga cgacaccgtg
     4441 ctcaagcacc ccttccgcac cggcgacgaa ctgctgcggc tctccaggga caccggcctg
     4501 tccatctcct ccctgatgct ggagaacgag cgggcctggc gctccgagga cgagatccgc
     4561 tccggtctgc tggacatctg gcgcgtcatg caggcgtgcg tctcgcgcgg catgtcccgt
     4621 gagggcatcc tgcccggcgg cctgaaggtc cgccgccgcg ccgcgaactc ggcccgccag
     4681 ctgcgcgccg agggcgactc gcaggcccac gcgatggagt ggatcaccct ctacgcgatg
     4741 gcggtcaacg aggagaacgc ggcgggcggg cgcgtggtga cggcccccac caacggcgcg
     4801 gcgggcatca tccccgccgt tctgcactac tacatgaact tcgcggccgg cggatgcacc
     4861 gaggccgaga aggaagacag cgtcgtgcgc ttcctgctcg ccgccggagc catcggcatg
     4921 ctcttcaagg agaacgcctc catctccggc gccgaggtcg gctgccaggg cgaggtcggc
     4981 tccgcctgtt ccatggccgc gggcgcgctg gccgaggtcc tcggcggctc ccccgagcag
     5041 gtcgagaacg ccgccgagat cggcatggaa cacaacctgg gtctgacctg cgacccggtc
     5101 ggcggcctcg tccagatccc gtgcatcgag cgcaacggca tggccgcggt caaggcggtc
     5161 accgcggcga agatggcgct gcgcggcgac ggcagccaca aggtctccct cgacaaggtc
     5221 atcaagacca tgaaggagac gggcgccgac atgagcgtca agtacaagga gaccgcacgc
     5281 ggcgggctcg cggtgaacat catcgagtgc tgatgacata ggccctgacc agcgcttttc
     5341 tgtctttcag cgctgtcagg gccttccctg ccttcacggc ggaaagtccc tggatcgccc
     5401 ctgggacagg cgtgaaagtc cctgaaaagt ctgggaaatc cttcgtggat caacgtccga
     5461 ccagggggca tcgcatctgc tcgacgtcag cccctctccc tggcaccgtt cgaacagttc
     5521 tgcaggcgat atctgcgccg gggaccgggc acggatggcg ataactcagt aacaagagtt
     5581 ttgttaaagt aggttcatgg tcacctcctc cgctcccggc gaaggcccca tccgtccggt
     5641 ctccgtctcc ctccacgaag gcacgatcgc cgccctcaag gcacgtaccg gcaaacgcgg
     5701 catgtccgcc tacgtcgaag ctctcatcca gcgccagcta gagcgggacc tgctgcgcga
     5761 actcatcgaa gacgctgaag ccgaacacgg cccggtggac caggtagcgg tcgaggccaa
     5821 gcgagcgatc ctccgcggtg acgtggccga ctcggcggac gcagcgtgag tgggacgctc
     5881 gtcctggact gtgagggatt gtccaaactc gtacggcgct cccctgaagt cacggagtgg
     5941 ctggccgcgg ccgaggacga ggacatccgc gtggtcacca gctccgtcac gctggtcgag
     6001 gcacgcgacc ccaaggtcaa ccaggcccgc ttcgaccatg ccgtctcccg cgtgaacatc
     6061 atcccgccca ccgaagccat cgcccgccat gccagcaagc tcctcgccac tgccggcctg
     6121 cacggccaca agtacgccct cgacgccatc gtggccgcca cagcactcgc ctcgcccgcc
     6181 cccgtgaccg tgctgacgtc ggaccccgag gacctcctcg tgctgtgccg ccccggcgtc
     6241 cgcatcgtca aggtgtgacc cggcgaggcc gcacctcggt ccatcccttg tgcggatcgg
     6301 agcgctgcgc ggggagcctt gaacagcggc gggctcgcgg tgaacatcat cgagtgctag
     6361 gggacgcgcc gtaggccgtc gccgcgacgt tccgccgacc ctcggccctg actgtccgtc
     6421 acccccgttc cgggccaccg ggtccacgag cgtgggcgcg gccgtgggga agccgtgctc
     6481 cgtccgtccg gggctgtccg tcggccgccg gttccgcata cgcccggcgg ccggcccgga
     6541 cgccgggcga cgggcttcgg cggttccccg gctccccggc gcccgcggcc cgtcgaaggg
     6601 ccggggcgcg ccgccctttc ccgctccggt gccgctcatc ggcatgacgg cgtccgccgc
     6661 cgcgtcgggg accgggtacg tccggcgtcg gggacgacgc cccgtaccgg ccgccggtgc
     6721 ggggagcacc ccggccccat gcccctccgc tcccctccgt tacgccccgc tcaccgcggt
     6781 ctcgcccgcg gtggggcact tcttccatcg tgctctatgc accggcgggc acggccggac
     6841 gggcagccga tcagtagcct gatcattgac gctccgtcat cgacgggcgt ccagccctcc
     6901 ccttccccgt cttcccttcg ccggtccccc cacgaccggg acaggagcca ctccgtggat
     6961 gtgcccttcc ccatcgaccc ggcaggcagc gatatcccca ccgagggcgc acggctccgc
     7021 aaggccggag ccgccaccct cgtgacgctg cccggcggca tcaccgcgtg ggccgtcacc
     7081 catcactcgc tgctcaagca gctgctcacc gacgaccggg tgagcaagga cccgcgtacc
     7141 cactggccca cctggcagcg cggggagatc accccggact cctggctgca cacctggctc
     7201 ggcgtggtca acatgttcac ggcgtacggg gaggatcacc gcaggctgcg caaactcgtc
     7261 gcgcccgcgt tcaccgcccg tcgcaccgag gccctctccg gtgagatcga gagcatcgcc
     7321 ggccggcttc tggacaccct ggagacggtc ccggccggcc gggggatcga tctgcgcgcc
     7381 gggtacgcgc acccgctgcc gatgcaggtc atgtgcagtc tgttcgggat tcccgagcag
     7441 ctccggcctc gtaccgcggc ggtcatcgcc cgcatcttcg agaccgacat cggtccggag
     7501 gaggccgcgt ccacctggcg ggagatccag gaggtgctga ccgaactggt cgcgctcaag
     7561 cgccccgatc ccggcgacga catgaccagt gtgctgatcg ccgcccggga cgaggacggg
     7621 gcccggctga gcgaggagga actgctgcac accctgtggc tggtgatctc cgccgggttc
     7681 gagaccaccg tgaatctcat cggcaacgcc gtgcacgccc tgctcagcca tcccgagcag
     7741 ctccgtctcg tcaccgcggg cgaggcgtcc tggagcgatg tggtcgagga gaccctgcgc
     7801 tgggccccga gcgtggccag cctgcccctg cgcttcgccg tggacgacat cccgctcccc
     7861 gacggccgga cgatcgccag gggcgaggcg atcctccccg cctacgcggc ggcgggccgg
     7921 gacccggatc agcacggcga cgacgccgac gacttcgaca tcacccggcc cgcccacggg
     7981 catctggcgt tcggccacgg cgtgcacatg tgcctgggcg cgcccctcgc ccgcctcgaa
     8041 gcgcggatcg ccctgccggc cctcttcgca cggttccccg gcctggcgct cgccggggaa
     8101 ccgcgggacc tggtgcccat ggagtcgttc atctcgaacg ggttccgggc cctgcccgtc
     8161 accctgtgac cgctcggcga gccggcggcc cggccccgca cgcccggccg ggtcctatgc
     8221 ggcggacgtg cgccgtgccg cccggcgccg gcgcaccgcc gacgccagct cgcccagcag
     8281 ttcctccgtc cgctcccatc cgatgcaggc gtccgtcacg ctctgcccgt aggtgagcgt
     8341 gtcgaggggg cccggctcct gacgtccctc gcgcaggaag ctctccacca tcagcccggc
     8401 gatcccttcc tcgcccccgg cgatccggtc ggcgatctcg ccgacgacct ccgcctgccg
     8461 gtggtggtcc ttgccgctgt tggcgtggct tgcgtcgatg accagttgct cgggcatgcc
     8521 cgccccggcc agcagcttca gggcgtcgcg gatgtcctcg gggccgtagt tggggccgcc
     8581 gcgcccgccg cgcaggatga cgtggcagtc ggggttgccg ctcgtggaga cgatggagcc
     8641 gttgccctgt tcgtccacgc cgaagaagac atggtcgccc gccgccgccc ggcatccgtc
     8701 gacggcgggc tgcaccgcgc cgtcggtcgc gttcttgaag ccgacgggca tcgacaggcc
     8761 cgaggcgagc tggcggtgca cctggctctc cggcgtacgc gcgccgatcg ctccccaggt
     8821 caccgcgtcc gcgatgtact gcgggctggt cggctccagg aactcgcagc ccaccgggag
     8881 tccggtgtcg agcacatcga gcagcacctg gcgggcgatc cgcagcccgt gctggacatc
     8941 gtgcgtcccg tccaggtggg ggtcgttgat gagccccttc catccgagcg tcgtacgggg
     9001 cttctcgaag tacacccgca tcaccacgca caggtcctcg tggagcgggg cgacggccgc
     9061 ggcgaggcgc cgggcgtaat cccgggcggc ggccgggtcg tggacggagc aggggccgac
     9121 gacgagcagc aggcggtcgt ccgccccagt gagcacgtcc tcgacggcgc gtcggctgtc
     9181 ctggaccaga gcggcgcggg tggggcccaa cggcaggtcg ccgagcagga cggacggggc
     9241 gatcaggggc tggaatccgg tgacgcgcag gtcattggtg cgcagggggc ccgaggtggg
     9301 cgtggtcatg gggtgatcct gtctctgtgc cgaggcaggg tcccggtcct gcggtgctac
     9361 gtccgcatca cccgttacca gccgcctcaa cgacgaaaag gcagagacgg atcgtctctg
     9421 ccctgctggc tccggatgat tggtcggtgg tcagcgcatg tgaccaccgg ctccacccgg
     9481 agccggcgta aagcgccgat accaaccaaa caacgtagac atgcggagga ccctaacacg
     9541 ggtgatcggc cggtcagggg cccgccggag cggtgagccg acgggcccgc cggaccggct
     9601 cgtggctcac ccgtcccggg cgtcctggag agtcccggaa gttcaccaac cgctcagaga
     9661 cgttcaggcg ttcgcgacga tgaagcgatt tcggtcacat ataggcttcc cacaatcacc
     9721 cacaaggggt tgactggggg tcacgcatgg tgacgcggtt cgcccccatc ggctcgcgaa
     9781 tccggctccg atgccccggc cccggcggag gaaagaggac agcgatgacc gcctcacctc
     9841 ggacagtgac cctttggcca cgagtggtgg gcgccgggcg tccgcactcc gccggaccgg
     9901 ccccatgcgc gagcacgaga tattccgcgc tctcaccgtt cttccgtacc gttccgcaga
     9961 ggggctacaa atgagccaga tcgctttacc gacgtttcat atgccgttcg agagcacagg
    10021 gtgcaatccg ggcatcgcgg aaaccaggaa ggccgcctgg gagtgggcgg aatcccatgg
    10081 cctgttcctt tccccgcccg cccggaaaaa gatgatccgg acacgccccg aactctggat
    10141 ttccctcatt ttccccaggg cctcccagcg ccatctcgac ctcttctgcc agtggctgtt
    10201 ctgggcgttc ctggtggacg acgagttcga cgacggtccg gccgggcgcg atccccggat
    10261 gtgcgaggag gcgatcgccc ggctcgtcga cgtgttcgac ggagccgtac cggtcggacg
    10321 catggagcac gccctggacg gactgcgcga gcggacctgc cgggaccggt cgccgcgctg
    10381 ggtacggcag ttccgccggg acaccgtcgc ctggctgtgg acgtactacg ccgaggcggt
    10441 cgagcgggcc gccggacagg tcccgagccg ggccgacttc gtgaagcacc gccgggactc
    10501 ggtggccatg cagcccttcc tgtgcctgca cgagatcacc gccggaatcg acctcccgga
    10561 ctccgcccgg agcctgcccg cctacatcgc cctgcgcaac gcggtgaccg atcattccgg
    10621 gctttgcaac gacatctgct cgttcgagaa ggaggccgcc ctcggctacg agcacaacgc
    10681 cgtacggctc atccagcggg accggggaac cagcctccag gaggccgtgg acgaggccgg
    10741 gattcaactt gcccggattg ccgagcgggt acagcgggcg gaaaaggaac tggccgagga
    10801 aatcgacgcg gcggacatcg gcggaggcac ccgggccgcg ctggaacgct gcgtacagga
    10861 ctaccggggg ctcgtacggg gcgacttcga ctaccacgca cgcgccgagc ggtacacccg
    10921 tcccgatctc gtggagctgg acgagcggga ctcgctgtcg cggtacttcg ccgcctgagg
    10981 atccaagggt gtgaggagct gagggtgtga ggagctgagg gcctgaaggc cccagagcgc
    11041 ggcaccggcc gtgcacaggg cccggggact cccgccgagg gagtccccgg gcccttcccg
    11101 tggtgatcgg atcgagtcat gaaaggtcgg gacaggacag gacagatcag aggcgatcac
    11161 atggaagact gtggaaaccg gcaccaccac aggtcgccgt ctggccgcgc cgacggaacc
    11221 gctgttcccc cacacagctc ctgacctgct ggaatgccgc tcctttcacc aacgtccccg
    11281 gggaatcacg tgagatcgaa gcgaagagta tgggccacgg ctgccgtcgc gacggcagcc
    11341 gtggcgggtg tcctggtcgt ccagggggtg accggcacac ccaccaccgg cgaggacccc
    11401 gacgccaagt ccgctcccgc gcaggccgat gtgcgcaaga ccgcgctgaa ggtgtccgag
    11461 gacggcggct ccgcctccct gcggcagcgc agcaccgaac cgttcagcat gctcggcgtc
    11521 acctggaccg acccggccgc caaggtgtcg ggcgaggtcg aggcacgtac ccggtccgcc
    11581 gccacgggca gctggaccgg ctggctgccg ctcgacacgg agatcgacgg gcgtaccgag
    11641 gcgggccgcc ccggcgtccg gggcaccacc gaaccccgct gggtcggtcc gtccaacggc
    11701 gtggaggtcc gcgtcaccgc cggggacggc acgtcggccg ggctcccgaa ggggctgcgg
    11761 ctggacaccg tggaccccgg agggagcacg tccccggccg ccgaaccggc cgcgtacgtc
    11821 gctgccgaca ccgcaccggt ggagcccgcc gaagatccga cggccaccga ggaaccggcg
    11881 ccgacacaga cgcccgacac tccgccgtcg cccgatccgt ccccggccga caccaccgga
    11941 ccggacccct ccgcgacgac ggagaccccc cggacgccca gctccgaccc ggacccgatc
    12001 ctgacgtccc cggctccgtc gcagccgccg tccgtgaccg ccgagccgtc ggcgaccctg
    12061 ccgcccgccc cgccgtccac ggtgccgcag ccgccggtcg tcccgcgcgc cgggtggggc
    12121 gcggacgagt cgctgaacaa cgagtccccg gactacatgt cctcggtcaa ggccgtcttc
    12181 gtccaccaca ccgcgcagac caacagctac tcctgcgccg actctcccgc catcgtgcgc
    12241 ggtctgctcg ccttccatgt gaagtcgaac ggctggaagg acctcggcta caacttcctg
    12301 gtcgacacgt gcggaaagat cttcgaaggc cgtaagggcg gcgtggaccg ggcggtccag
    12361 ggcgcgcaca cctacggctt caaccgcgac accgccggta tcgccgtgat cgggatgtac
    12421 accgacacga aggccgcgag cgccgcgacc gcctcggtcg cccggatcgc cgcgtggaag
    12481 ctcggccagt acggcggcga ccccgccggt acggtcccgc tgaccgcggg tgcggcggga
    12541 aacaactacg ccggtacgaa gttcaccgcc gggaagaagt actccttcca gcggatctcc
    12601 ggccaccggg acggcttcaa cacccagtgc cccggcggca agctctacgg tcagctctcc
    12661 gcgatccgcg gcctcgccgc gggccccgtc accggcctga ccatcaagtc ggtgaccgga
    12721 gcgagcgctt cgggcagcac ctactacacc acgtcggaca tcactgtcgg ctgggcggcc
    12781 tccactcccg ccgcgttcat caccacgtac gacctgctgg tcgacgggaa gtccgtggcc
    12841 accaccaagg gcagcgtcac ctcggccggg gccacgctcg ccgcgggcag ccacaaggtc
    12901 caggtccggg ccacccacca gtcggggagg accagcctct ccgcgacggc gaccgtcgtc
    12961 gcggaccgta cgccgcccgc cttcccggcc aggccgagcc tctcgctgcg caccggcacg
    13021 gtgagcacca ccgccgtccc gctcacgctg aagtggaagg ccaccgacgc ggcctcgctc
    13081 aaggaggtca ggctcaccac gcccacggcg aagacgtacg gtccgacgac ggtcagcgcc
    13141 tcgcacaccg cgaagtccgg cgtggcgacc gcctggagga tgacggcgta cgaccgtgcg
    13201 ggcaacacgg cgggcgcctc ggtcaccggt actccggtca tcctcaagga gtcctcggcg
    13261 aagaagtccg gcagctggtc gacgaagtcc tcgtcccact acctgggcgg caagtcgtac
    13321 gcgagcggca ccaagaacgc cgccctcacc tggacgttca ccggccgctc ggtcgcctgg
    13381 gtggtctccc gggcctcgac ctccggcatc gcgtacgtct atgtggacgg cgtcaaggtg
    13441 gccacggtgg acctgaagtc ctccagcacc aagtaccgcg acgcgatctg gacgaagtcc
    13501 tggtcctcca gcgcgaagca caccgtcaag atcgtggtgg ccggcaccaa gggccgcccg
    13561 accgtcacca cggacgggct cgtccacctc acgtaggcgc cgcgtcccag tagtcgtcgt
    13621 cgggtgccgg ttcgtcaccg gtgcccgaca gcggcagggc gcgcagcgcc agtgcccacc
    13681 ccagccggtc ctcacccgac tcggcggatc tgccggtgag ttcggcgacc cggccgatcc
    13741 ggttgaggac cgtgttgcgg tggcagtaga ggagttcggc ggcccgcgcc gccgaacagc
    13801 cgtggtcgag ccagatgcgc aaggtgtcga gcagcgcgtc gcgttcggcc gccgtgtcca
    13861 gtacggggcc gaggtaccgg gagacgatcc gggcggcgat ctcgtggcgt ccggtgagca
    13921 ggacctccgt cagccggtcg tcgaacgccg ccgcctcgcc gctcttggca ggcagcgtgc
    13981 gcagcgtctg ctcggccagc cgcagcgccc ggcccgcacc gtcgagccgg tcgaactccg
    14041 gggacacccc cgcggtcgcc ccggtccgcc cgcgcagcag ctccagcagc atgcccgact
    14101 cccccgccgc caggcgcacg atgcccgcgt accgccccga gcgcggccgc cagaaggacc
    14161 agaggccgtg ctcgtcgagt acgggtgccg ggttgggcgg ggcggccggg tcctgggcgg
    14221 cgaccacgat cacataccgg tcgtgcagcg gtacgccgag tgcggcggcg gccgccgagg
    14281 cgacggccgg atcggagccg cgcccgtcga gcagcgcctc gaagagggcg acgcggcggg
    14341 tgtcctggcg gccctgcatc tccagctggg tgagccggta cgactcggcc atgaccaggg
    14401 agtaccggtc gatggtctcc cagacggcgc ccgccacatc gagctccacg tcgcggcggt
    14461 ccgccgtgcc cggctcccgg tgtccgggcc ccggctcccg gcgtcccgtg cccgcgcgca
    14521 ggtactccgc catgacctgc cacatcaccc gcccgccgcg ccggtacgcc tggaggacgg
    14581 tgtccagggg gaggttctgc tcggcgcggc gccgtccggt ctcgcgggcc gcgtgctcga
    14641 agtcgccgcc ggtgggcggc agtccgccga agtcctccag ggcgctgagc agattgtcgc
    14701 ggcagatccg ccacaggtcc tcacggctga cgaggttctg cgccgcgtac gtaccgctgt
    14761 gcgcgtggat gtcgtcgacg accctgcggg tcagctcgtc gagctccggc agcagggcgg
    14821 cggccagatc gtgccgcaga ccgatgtcct cgccaccgcc ggacaacggc ccctgcgagg
    14881 tcggggagct cggggggctc tgtgggctct gtgggccctg agggactttc gcggacgcca
    14941 tggccaggag attaggcgaa tgccgcacac ggcgcacggc tgcgggtgcc gctgcccagg
    15001 tgagcggggc ggatggtggg cacctgcaca ttgtgcggag acggacgcac ggctgattct
    15061 gagggacatc agccgtgtta acgccatgtt tcccggagcg tgccatgtct ctcagcgtcg
    15121 cctctgtcct gggcgagtcc gcccgccggt atcccggccg caccgccgtg gtggacggcg
    15181 aggtgcgtct gacctatgcg gagctgtggg cgcggtcgct gcgctgcgcg ggggcgctgc
    15241 gggccgccgg ggtgcggccg ggcgaccggg tggcggtcct gctgccgaac tccgcgggct
    15301 tcctgtacgc gtactacggg gcgctggccg ccggggcgac ggtggtcccg gtgcacgcgc
    15361 tgctcgtggc ggacgaggtg gcgtacgtgc tgcggcacag ccggtcggtg gcgctgatca
    15421 gtgccgggcc gctgtggccg gtggccgagg aggccgcgcg ggcggccggg gtgcgggccc
    15481 tgaacggggc ccccgacggt gaaccgctga ccgccgccga gcccgccgag gccgccggca
    15541 ccgcggtgat cctctacacc agcgggacga cgggccgccc caagggggcg cggctgaccc
    15601 atctcaacat cgtcatgaac gcgtccgtga tcaccgcgga cctcctggac atgggcccgg
    15661 acgatgtggt gctgggctgt ctgccgctgt tccacagcta cggccagacg tgcgcgatga
    15721 acgcgacact gcgggccgga gcgacgctcg tcctgatgcc gcgcttcacc ggagcggcgg
    15781 ccctgacggc gctggcggcc gagagcgtga gcatcttcat gggcgtaccg accatgtacc
    15841 acgccctggt cgaggcggcg gcgctgagcg gggaggcggc gcgggggctg acgctgcggg
    15901 cggcggtctc gggcggtgcg gcgttgccgg tggcggtcct ggaacggttc gaggcggcct
    15961 tctccacgca ggtcctggag gggtacgggc tgaccgagac gtccccggcc gccacgttca
    16021 accagccgca tctgggccgg cgccccggca cggtcgggca tccggtgtgg ggcgtggaga
    16081 tcgggatcgc ggacgcggcg gtggacgagt cggtgcggct gctggcggac ggggagatcg
    16141 gcgaggtcgt ggtgcgcggc cactgtgtct tcgcgggcta tctggacgac ccggaggcga
    16201 cggcggcggc gatcgtggac ggctggttcc gcaccgggga cctcggggtg cgggacgcgg
    16261 acggcttcct gagcatcgtg gaccggaaga aggacctgat catccggggc gggttcaaca
    16321 tctatccgcg cgaggtcgag gagatcctgg tccggcatcc cgcggtcggc gaggtcgcgg
    16381 tgatcggggt gcccgacgac gcgcggggcg aggagatctg cgcggtcgtg gtggtccggc
    16441 cggacgcgga gccggtcacc ggggacgagc tgatcgcctg gtcgaaggaa cggctcgggc
    16501 ggcacaagta cccgcggatc gtccggttca ccgagcggct gccgctcggc ccgaccggca
    16561 aggtcctcaa gcgggccctg acggccacca cgtcctgagc gtcctgagag cgccaccggt
    16621 cccggccacc ccaccctgag cacgccaccg gaccccggcc accacaccct gagcgcgccg
    16681 ccgaaccccc ggccaccaca ccctgagcgc cgccgggacc tgagcgcgcc gccggacccc
    16741 gacgccaccg cgtcccgacc accaccgtca cccccgaacc acctgaccgc accgcgtccg
    16801 ggccgccccc acccccgtgc cgctcccccg gaggaacgca ccgccatgac cgtccccgtc
    16861 cccgtcagac ctcccacgac cgccccggcg ccaccggccg cctcacaacg cccctcggtc
    16921 aaagagaagt tgagcttctt cgcgggcaac ttcggcaaca tcctgctgtc caccacgatc
    16981 agctcgttcc tgctgctcta tctcaccgat gtgctcggca tcgccgccgc agccgtcggc
    17041 acgctgctgc tcgtcgtacg gatcatcgac agcctcgtcg accccttcgt cggctatgcg
    17101 gtggaccatc tgcccgccac cgggcgcggc cgattccgta cgtatctgct gatcggcggg
    17161 gtgctgggcg ggctcagctt cgcggcgctg ttcctggcgc ccgcgctgct gcccggcccg
    17221 ctcgtcgtcg cctggatcgt ctatctgctg tggggcatcg cgttcccgat gatggacatc
    17281 ccgctcaact cgcttctgcc ggtgatgaca tcggaccaga agcagcgcgg ctcgctggcc
    17341 gccatcaagg ggttcacgta tctcttcggc gggatgctcg tcatcgcggt gaccctgccc
    17401 gtggtgggga tgttctcctc ggagcgcacc ggctggatgc tgttctgcgc cgccgtcgcc
    17461 gtgctggcgg tcgtctgcac gaccacggcc gcgctggggg tacgggagcg ggtgcggccc
    17521 acccgcaccg acaagtacgg gccgcgcgac ctgctgcgga tcttctccgg cggccgggcg
    17581 gcgggcgtgc tgctgacggc caaggtgtcg acgtcggcgg cgagcgcggc gacgctggcc
    17641 acgatgccgt tctacttcct ctacaacgtg ggcgacaagg gcctggtgac ggtggccgcc
    17701 ctggtgatga tggtgccgat ggccggcggc agcgtcctgg cccccgcact ggccgcccgg
    17761 atcggcggga agccggtcta cgccggggcg ctgaccgtgg ccgcggccgg caacgccacg
    17821 ctgttcttca tgccgtacga cacggtgccc gccctcatgt gctgcctggc cgtggccggg
    17881 ttcggcatcg gggctgccgt gacgctcaac tacgtgctcc tggccgagct gacggattac
    17941 gtggagtggc ggcacggaca tcgcgccgaa ggagccctgg cctcgctggc ctcgttcgcg
    18001 gcgaaggccg gtggcggtct cggcggggcg gcgaccgcgt actgcctggg gctgttcggc
    18061 tatgtcccgg gggcggacca gacccagcgg gcgatggacg gcatccggta cgcgcaggcg
    18121 ggggtgcccc tcgcgctcat cctgatcggc ggcggggtgt tcctggccta cccgatcacc
    18181 cgccgggtct cggtgacgat cacggaggaa ctgaccgcac ggcgcgcgac cgcctcggca
    18241 caagggacga gcgacgatga gtgacccgac gtggggcgac tggcacgggc agtggatctg
    18301 gggcgaggag cggggcatca ccccgccggg cccggggtcg atgctcgggg cgccggaccc
    18361 ggaggtgtac gaccggcgga tgatgttccg gcgcgacttc gagctgtcgc gggtccccgc
    18421 ctcggcgccg taccgcatca cgtcggactc ccggcacgtg ctgtacatca atggcgtcga
    18481 ggcggcacgc ggccccgtcc ggcacgggcc ccggatgctg cactacgaca ccggggacgc
    18541 ggcaccgctg ctgctccccg gccggaactc gatcgcggtg ctcgtgcgcc actacggaca
    18601 cgcggtgccg tggtgggagc cgtcgccgtg gacgttcgag ctgggcggcg gagctctggt
    18661 ggccgagctg cggctgaccg aggaccggtg gatcgccacg gactcctcct ggtcctgccg
    18721 tccggccggg gcatggacgc cgcagcgccc gcactcccag ctggtcaccc agaccccgga
    18781 gtcgctggac gcccggctgc tggacccggc atggacgcgg gccgtaccgg gcggcccgac
    18841 gccggaccgg cccgcccggg tgctgtccac ccgggccgtg gtgggcccga agggcggcac
    18901 ccggccggac tcggagccgt acggcgcgct gctgccccgg ccgctgccgc cgctcaccga
    18961 cacggtccgg ggcgccgagt ccctgcgtac cgctccgctg ccgggcccgc tgccgccgga
    19021 cccgcggcag gcgctcgccg aggcgctccg ggccaccggg gacgccgccc ccgccacggc
    19081 cgacgccacg cacccgctgg gcgcggcgcc cgtgctcctg ctcgtcgact tcggccgcgt
    19141 cgtcgcgggc catctgcgct tctcctgcac ggcggagtcc ggcaccgaga tctccggggc
    19201 cctggtcgag ctgcccacgg ccgccgccct cgacgccgcc aataccttcc actacatcgc
    19261 ccggggccac gaggacacct tcgagacgtc cgacccggtc ggcgggcggt acgccctgct
    19321 ggtcgcgacg ggtaccggca gcctccggct gggtccggtc caggtgcgtg agcggctgcg
    19381 cccgcgcccc gccggaccgt acttcagctg cgacgacgcc gagctgaacg agatccaccg
    19441 ggtgggcctg cgcaccgtgg acctcacggc gcaggacgcg tatctggact gcccgacccg
    19501 cgagcagcgg gcctggacgg gcgactcggt ggtgcaccag gcggtcgacc tggtcaccaa
    19561 tcccgactgg agcctggccc gctggagtcc gcagctggcc gcgcagcccc gctcggacgg
    19621 catgttgcgg atggtcgcgg ccggggactt cgcccgcgac ccgatcccga cgatccccga
    19681 ctggtccctg cactgggtgc gctcggtgca ccagctgtac cgctgcacgg gagaccgtga
    19741 gctggtggcg cggctgctgg cgacggcgga gggtgtgctg cgctggttcc tgcccttccg
    19801 ccgccccgac gggctgctgc accgggtgag cggctgggtg ctgatcgact ggtcgccggt
    19861 gcaggtgacc ggggcgagcg cggcgctcaa cgccctgtgg gcgcggggtc tcgcggactt
    19921 cgcggagatg gccgactggc tgggcgacgc ggggcgggcc cgctgggcgc gcgaggccca
    19981 ccagggggtg gtcaccggct tcgaggcgtt ctgggacgcg gaccggggcg cgtaccgcga
    20041 caacctggac ggcgggcggc tcggtacgtc ggtcagcgag cacacccacg cggcggccgt
    20101 ctgcggccac ctcgtaccgg atcaacgcct gggcgctgta cgggagttgc tgctggaccg
    20161 ggcggcgatg ttcacccggt caccgatgcg gcaccggggc agcgacgccg gcggtccgct
    20221 gacgtccgat ccggtgtccg accgggaggg gcccgactgg gacaccgaga gcctcgtcgt
    20281 gggcgcccag ccgttcttcc ggtacgtcgt gcacgacgcg ctcgcgctgc tcggcgcggc
    20341 cgaccggatc gaggggctct gccacgactg gacggccctg ctggagagcg gcggctcggc
    20401 gttccgcgag tgctgggagg gcggttcgta ctgccacgga tggtcggcca cccccagccg
    20461 tgatctgctg gtgcacacgc tcggcgtcac cccggccgag cccggctacc tgcgggtacg
    20521 cgtcgcccct cggctcggcg ggctctcctg ggcgcgcggg gcggtgccca cccccggggg
    20581 cctggtccag gtcgacgcga cgccggaacg ggtacgtatc gaatcaccgg ttccggtcga
    20641 ggtgctgcac cccgacggct ccctcaccca ccatccgtac ggcacctcgt ccatcgactt
    20701 gcgaaagggc tgatgcgcac catgtccgag acccaggtgg agataccccc gcaggcggcc
    20761 accgcccacg gcgccgtccg cggcacgctg gagcacggtg tggcggtctt ccggggcatc
    20821 ccgtacgcgg cgccgccggt gggcgcgcgc cgcttccggg cgccggagcc gccggagccg
    20881 tggcagggcg tccgggaggc cgtcgcgtac ggcccgacgg cgcccaagcg cccctacgcc
    20941 ccgccgctgg acgagttgct gccggacccg gaggtggc
//
