LOCUS       NZ_LWLE01000019        23222 bp    DNA     linear   CON 27-MAR-2024
DEFINITION  Streptomyces sp. TSRI0281 scaffold26, whole genome shotgun sequence.
ACCESSION   NZ_LWLE01000019
VERSION     NZ_LWLE01000019.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. TSRI0281
  ORGANISM  Streptomyces sp. TSRI0281
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 84385)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 84385)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra,H. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-APR-2016) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2016
            Assembly Method                   :: CLC NGS Cell v. 8.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905125.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:37:03
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,600
            CDSs (total)                      :: 8,518
            Genes (coding)                    :: 8,175
            CDSs (with protein)               :: 8,175
            Genes (RNA)                       :: 82
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 76
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 345
            CDSs (without protein)            :: 343
            Pseudo Genes (ambiguous residues) :: 0 of 345
            Pseudo Genes (frameshifted)       :: 151 of 345
            Pseudo Genes (incomplete)         :: 273 of 345
            Pseudo Genes (internal stop)      :: 33 of 345
            Pseudo Genes (multiple problems)  :: 102 of 345
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:13:17
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: >23222
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LWLE01000019.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..>23222
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="True"
                     /product="atropopeptide"
                     /product="lanthipeptide-class-iii"
                     /region_number="1"
                     /rules="atropopeptide_p450"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     gene            <1..382
                     /locus_tag="A6A29_RS46110"
                     /old_locus_tag="A6A29_39015"
     cand_cluster    1..>23222
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="atropopeptide_p450"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="neighbouring"
                     /product="atropopeptide"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..15537
                     /candidate_cluster_number="2"
                     /contig_edge="True"
                     /detection_rules="atropopeptide_p450"
                     /kind="single"
                     /product="atropopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..15537
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4490:5537](+)"
                     /cutoff="10000"
                     /detection_rule="atropopeptide_p450"
                     /neighbourhood="10000"
                     /product="atropopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4491..5537
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="atropopeptide_p450"
                     /neighbourhood="10000"
                     /product="atropopeptide"
                     /protocluster_number="1"
     CDS             <3..382
                     /codon_start=2
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A6A29_RS46110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A6A29_39015"
                     /product="hypothetical protein"
                     /protein_id="WP_206745373.1"
                     /transl_table=11
                     /translation="RWVSFDPLSEGHDSPVADRHGFVGAEDVVAGESETATRARVHESL
                     SAVREAFGLPQEPALRDVTVGIRPIPTGNGILCAPLANAPGVVALAAHPGVTLAASLAQ
                     RAAEHVGDPDPRWRRDDVGAEE"
     gene            360..536
                     /locus_tag="A6A29_RS45395"
     CDS             360..536
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A6A29_RS45395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_158074458.1"
                     /transl_table=11
                     /translation="MMWEPRNEAWETKLAALRSFHRHHGYLAPRKDAVRGEAEDELVAI
                     GQLMANLHLHSPT"
     cand_cluster    609..>23222
                     /candidate_cluster_number="3"
                     /contig_edge="True"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    609..>23222
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10608:>13222](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      10609..>13222
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="2"
     gene            640..822
                     /locus_tag="A6A29_RS44920"
     CDS             640..822
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A6A29_RS44920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_143197060.1"
                     /transl_table=11
                     /translation="MTRGRRRVGGSNLGDSSTAQQVASGFGASNPNNGAQSNGSGFTAL
                     GESNSHESLVWNPLP"
     gene            complement(1023..1196)
                     /locus_tag="A6A29_RS45400"
     CDS             complement(1023..1196)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A6A29_RS45400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_158074459.1"
                     /transl_table=11
                     /translation="MDATCVFMPVSHSTGVTKQVEAAEPLAYQGINGLAAVTMAMTPEG
                     SPWVRAAAVRVW"
     gene            complement(1196..2176)
                     /locus_tag="A6A29_RS23850"
                     /old_locus_tag="A6A29_39020"
     CDS             complement(1196..2176)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010047861.1"
                     /locus_tag="A6A29_RS23850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_39020"
                     /product="phosphotransferase"
                     /protein_id="WP_073722654.1"
                     /sec_met_domain="APH (E-value: 3e-11, bitscore: 36.0,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRDQLAGAARAALGGGRRLEAVERLAGGTTKGVYRLTMDDARTA
                     IAYLWEDSENYWPTTEHDGDLADPFSPGTGLDLFEAAHARLEALGLRVLEIHLADRDRT
                     HYPAELAIVEDVPGEDLMGLRNRDPRAAEPTMMRLAESLATMRGHRAQSFGKVALIDAG
                     GTSRSASCEQAALAFALRCLAEATARDHRIADARDQLEERLRQLTAAVRPRAEYSVVHG
                     ELGLDHVRVDRDGHPVVIDIENLLYFDVEWEHVFLRLRHSDSQYQQLAVDGLDEDRLAL
                     YKLTQHLSLTAGPLRLLDGDFPDREFMRGIAEHHLNEALALVPSG"
     gene            2827..3777
                     /locus_tag="A6A29_RS23855"
                     /old_locus_tag="A6A29_39025"
     CDS             2827..3777
                     /NRPS_PKS="Domain: PKS_KR (21-159). E-value: 9.5e-13.
                     Score: 40.4. Matches aSDomain:
                     nrpspksdomains_A6A29_RS23855_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016471235.1"
                     /locus_tag="A6A29_RS23855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_39025"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_073722655.1"
                     /transl_table=11
                     /translation="MSPTPSTPPWDVRRLPRADDSVFLVTGGNAGIGYFVAEQLSATGA
                     TVVLGSRNPDKAEAAMASIRARVPGARVRAVRLDLADLSSLETAVESLEVECLDAVVHN
                     AGVALDVPPRRETGDGHELMFGTNHLGHFVLTQWLMPLLSAAPAARMVTMGSFAAKSER
                     LDLDDLQSHKDYRPKRAYGRSKLAQMYFGVELERRLRAVGSTVASVVVHPGGALDSLTP
                     SRPPVHVRNTGARLSAAPAALLLQGKHAGAWPAVRAVLDPAVRGGQLWGPRVFGLRGEP
                     RREPLWTHLADTSVAARLWDASCDLTGLDLGVAPG"
     CDS_motif       2890..2985
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A6A29_RS23855_0001"
                     /evalue="1.30E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="A6A29_RS23855"
                     /protein_end="53"
                     /protein_start="21"
                     /score="17.8"
                     /tool="antismash"
                     /translation="VFLVTGGNAGIGYFVAEQLSATGATVVLGSRN"
     aSDomain        2890..3303
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A6A29_RS23855_PKS_KR.1"
                     /evalue="9.50E-13"
                     /label="A6A29_RS23855_PKS_KR.1"
                     /locus_tag="A6A29_RS23855"
                     /protein_end="159"
                     /protein_start="21"
                     /score="40.4"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VFLVTGGNAGIGYFVAEQLSATGATVVLGSRNPDKAEAAMASIRA
                     RVPGARVRAVRLDLADLSSLETAVESLEVECLDAVVHNAGVALDVPPRRETGDGHELMF
                     GTNHLGHFVLTQWLMPLLSAAPAARMVTMGSFAA"
     gene            4491..5537
                     /locus_tag="A6A29_RS23860"
                     /old_locus_tag="A6A29_39030"
     CDS             4491..5537
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     atropopeptide: atropopeptide_p450"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000173: Biaryl bond formation (60% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018089189.1"
                     /locus_tag="A6A29_RS23860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_39030"
                     /product="cytochrome P450"
                     /protein_id="WP_073722656.1"
                     /sec_met_domain="atropopeptide_p450 (E-value: 1.1e-183,
                     bitscore: 602.3, seeds: 287, tool: rule-based-clusters)"
                     /sec_met_domain="p450 (E-value: 1.1e-14, bitscore: 46.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPMHRVGGSGRVIEFAPRIDELLTRYRDASLFRLEPDTIGISGAD
                     LMDGLLRSRPANAEERPTFKPVQRRLVGRADAATFMQAVGSDVRNALQRPLDDTVDLTG
                     RWPHVAHVYLRDLVFGNERLRFRVLVDRRLELTPKLTWSAVASGAALLGRPGQDVPLSK
                     LAALVLDSKSYSDRRYAMYLYRRVAAPVCFTVSALVTNALWLGAPFSDDVSNRNIILEA
                     LRLLPPSWNILRMASPEFSDVDARIGPKDDVLLLPLLSHRNPKLWDEPDAFLPDRWDEL
                     DGETHPGYLPFGHASERCWGRHMVLPLAERLLDIVRRDGLVVSPDQTRGKVELDGLLEV
                     SEVRMTRP"
     gene            complement(5905..6954)
                     /locus_tag="A6A29_RS23865"
                     /old_locus_tag="A6A29_39035"
     CDS             complement(5905..6954)
                     /GO_process="GO:0042546 - cell wall biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020904.4"
                     /locus_tag="A6A29_RS23865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_39035"
                     /product="SMI1/KNR4 family protein"
                     /protein_id="WP_073722657.1"
                     /transl_table=11
                     /translation="MREGAVGYFEGFDVAGFWDDSAYALGEYVEEAPSSRELIASLEEE
                     LGGYRLPGSYIALMTAHNGGIPTRVHFPMTEPTSWAEDHIEITGIRGIGRTRPQSLGGE
                     YGSLFWIDMWEYPDIGVYFADTPSAGHDMLALDYRACGRHGEPTVVHVDQEGDFAITSV
                     AENFEAFVTGLVDGSVYDTSEQDRLAALATVRDGGFSPALLRAFREVADVLPDADRHMR
                     ALAETVVRDKGFFALHADTRSMLMYDYLFWLFTSFNQVDSFERYVSAPPEHERSYALPD
                     YELMIAFDLVSEPYGFRTGGYAPGFLEEWWKSRIASGHIVETADGFRLTDAAIAALLDE
                     LATVAGAGG"
     gene            7371..8600
                     /locus_tag="A6A29_RS23870"
                     /old_locus_tag="A6A29_39040"
     CDS             7371..8600
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006127327.1"
                     /locus_tag="A6A29_RS23870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_39040"
                     /product="low temperature requirement protein A"
                     /protein_id="WP_107468308.1"
                     /transl_table=11
                     /translation="MTGRNPEEHGRTSTPLELLFDLTFVVAVGTAADHFAEMVAEGHPG
                     QAVTAFVLAMFAISVAWISFSWFASAFGTDDWLYRILTMVQMIGVVVFSLGLPAMFHSV
                     DEGGHLELRVMVIGYVVMRIAMLLQWWRAARDSPAFHDVGMANIRWTAIVQLGWIAVAF
                     THLPLAAVFTAFVILGALELALPLLTQGSADGTPWHPHHVAERYGLFAIIVLGEGVVGT
                     VASSGGLLGGADGMHWSGNGIAVVVAGVGLTFGMWWVYFATPFGDVLVHRRGRGYLFGY
                     GHIPLFIGIAGAGAGLHVAGLQLEHHSELSDVAVVLSLAIPVGLYLLMVYLLHTLLLSA
                     ADRFHLLLISLTLVLLLTAVLLSAVGIAIAVCLLIVMLAPFVTVIGYETIGHRHQQRML
                     EALGTHTLSR"
     misc_feature    7417..7432
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.19"
                     /tool="antismash"
     gene            8804..9544
                     /locus_tag="A6A29_RS23875"
                     /old_locus_tag="A6A29_39045"
     CDS             8804..9544
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543096.1"
                     /locus_tag="A6A29_RS23875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_39045"
                     /product="DUF6193 family natural product biosynthesis
                     protein"
                     /protein_id="WP_073722658.1"
                     /transl_table=11
                     /translation="MPTSPDPAILYPDVVGFGSLAAALRAAAEGCLADVPVTASVSDPL
                     RHATVASTLPHREPLEISAWSHERRWSIRGTEPFQSMPLIDGRTDVLADIARATRAWHD
                     GLFLDDIRRAAPFVHLTGRFEVPDNDPARLTESEWQGLRQEAAELEYVWQETHQSLVEA
                     AHAEPALRALYPFTSHWALRFSTSTRPDLTVVGPRLGANADGTYGVGSVMIGQDIGQFA
                     TAQEAVAVAVRLLPSGLGPTTLGG"
     gene            9696..10148
                     /locus_tag="A6A29_RS23880"
                     /old_locus_tag="A6A29_39050"
     CDS             9696..10148
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A6A29_RS23880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A6A29_39050"
                     /product="hypothetical protein"
                     /protein_id="WP_143197062.1"
                     /transl_table=11
                     /translation="MKLLEIQHVDADVDFYGLSLQDADDGWLSTTLPEGFAQGRFLSEQ
                     PGRIDFTSAGHTQTVSFDAEIWSGPAQVPFGEWDESATARIECRSGELRLWAVAGGPAP
                     RSIVLPHASATWNVRVRCRGRAAAARACRVGVPHGLEQYLAQFWPV"
     misc_feature    complement(10561..10573)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.11"
                     /tool="antismash"
     gene            10609..>13222
                     /gene="lanKC"
                     /locus_tag="A6A29_RS23885"
                     /old_locus_tag="A6A29_39055"
                     /pseudo=""
     CDS             10609..>13222
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015611152.1"
                     /locus_tag="A6A29_RS23885"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="A6A29_39055"
                     /product="class III lanthionine synthetase LanKC"
                     /pseudo=""
                     /sec_met_domain="micKC (E-value: 1.7e-231, bitscore: 762.9,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 4e-15, bitscore: 48.2,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.3e-09, bitscore:
                     29.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPEYAAYCQADRHFYDAPHRSVSRPEEDRTFYVPVRGDAPEGWS
                     RSRRGDWLSYAPSDIRLPSQGWKIHVSAALDNAESVLRRVVEHCLAQRLPFKCVPTPRL
                     LHLRNAKYADRAGSGKFITVYPPTPERFPEVCAALTELLAGEHGPYILSDLRCGDGPVH
                     TRYGAFAARFCPGPDGRPVPAVADPQGRLVPDERGPSFRVPGWVTPPDFLHPYLEARAS
                     VGLTGLPYTVEKALHFSNGGGVYLGRDTRSGEQVVLKEARPYAGLAADGADAVTRLVRE
                     RTALEQLAGLDCVPAVRDVFEVGDHHFLVLQYVPGSPLNTVFAHRFPLSRQNPTSEQLA
                     EHVAWAERVYDQVERAVEAVHARGIVISDLHMSNVMVDEETSRIVLLDFEAASRTEERA
                     RQIVANPAFVAPTDRRGTDIDRYALACLRLALHLPLTTLFALDRTKAVGLARNAARVFP
                     VDEQLLRPAVDEILRTTGDPAGPAGPAEPDRRPPAPGDWPRSRDSMARAIAASCTPERE
                     DRCFPGDIAQFATAAGGQSFGYGAAGVLYALHETGARQCEPAVDWLLRRVKDPASGTPL
                     GFYDGLTGIAWTLNRIGRPAEASDLIRVVLEQPLEGLPAGLHSGYAGIALALDDMARTA
                     AVDGPALSAAADRCTALAVRALVEDPPSPRTGLMHGATGVALLLIHRYGKTGDTALIDL
                     AAAALRRDLERCRAGDGGLLVVEGKRLMPYLASGSIGIAAVIDAYLARRPDAALEAAGR
                     ALLPTALSAFYIQPGLLRGSAGLLAHLAATPLLEAPDRARAIRLHTDLLESHAMSYEGE
                     LAFPGEQLMRLSMDLATGTAGCLLALGGALGQPATLPFLPLARHTLPR"
     gene            13268..13399
                     /locus_tag="A6A29_RS44250"
                     /old_locus_tag="A6A29_39060"
     CDS             13268..13399
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015611153.1"
                     /locus_tag="A6A29_RS44250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_39060"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_073722753.1"
                     /transl_table=11
                     /translation="MALLDLQAMETPADEAFGELATGSQVSLLICEHSSLSLTLCTP"
     CDS_motif       13268..13333
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MALLDLQAMETPADEAFGELAT"
                     /locus_tag="A6A29_RS44250_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       13334..13399
                     /prepeptide="core"
                     /locus_tag="A6A29_RS44250_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="27.30"
                     /molecular_weight="2078.4"
                     /monoisotopic_mass="2077.1"
                     /core_sequence="GSQVSLLICEHSSLSLTLCTP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MALLDLQAMETPADEAFGELAT"
                     /leader_location="[13267:13333](+)"
                     /alternative_weights="2096.4"
                     /alternative_weights="2114.4"
                     /alternative_weights="2132.4"
                     /alternative_weights="2150.5"
                     /alternative_weights="2168.5"
     gene            13703..15439
                     /locus_tag="A6A29_RS23895"
                     /old_locus_tag="A6A29_39065"
     CDS             13703..15439
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956282.1"
                     /locus_tag="A6A29_RS23895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_39065"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_241838635.1"
                     /transl_table=11
                     /translation="MRPAALVCLLLCSTGGTLAALALPAALGHTVDRLIVGGPVPWSGL
                     LLCAALTLAETACDAGAAVVGTSTTARLTAALRTRTVARVLAAEPRRTLDVPTGDLTAR
                     ITTQAADAAAAPTTAAGSVAGALLPVGAVVGLLLIDPWTAAALLLGAPLLIALLRTFTR
                     RTADANADYQRAQALIADRLTEALDGAETIRAALTGAREYRRVLEPLGALAEHGRRTWA
                     VYGKASGQSALLLPLLMLLVLAVGGLRLDAGAIGVGDLVAAARYAGLVVGIGSLTGALS
                     SLARSRAAADRLDPLLALPPVPHRSLGPVDGAPGKLELRDVGVGREGRPLLSGVGLVVP
                     GGSSLAVVGRSGSGKSVLAAVAGRLMDPDTGTVLLDGVPLDGMEPDRLRREVTYAFARP
                     ALPGRTVGETVAFGARTASHEEVRSAAREARADDFVALLPQGYATPLTDAPLSGGERQR
                     LGLARAFAHPGRLMILDDALSSLDTVTEHHVQRALAGRAGRSTRVIVAHRLSSAARADR
                     VAWLEDGRVRATGPHHVLWADPDYRALFRTDPPDASGLPGPEEPSSHNAARPAPADRTA
                     DR"
     gene            15436..17283
                     /locus_tag="A6A29_RS23900"
                     /old_locus_tag="A6A29_39070"
     CDS             15436..17283
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003966505.1"
                     /locus_tag="A6A29_RS23900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_39070"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_073722660.1"
                     /transl_table=11
                     /translation="MTASRPATAARRAGHGALTRVAGDARPFLRDRTGVLLRLSGWSLL
                     EFVQTFLGGFGVAKALDQGFLAGHPATGLLWLGVAGAATLPAQFATRQVFGRLADLVEP
                     LRDGLVRRAVSRALSGALAQPLGVTTRSLSQVTHQSEIARDGWAGLVLTLRSFVFTAAG
                     AVLGLLALEPGLLLLVLPPLLLGGALFAATLRPMAARQRDYLAADEAYAAHTGELSAAL
                     RDIAAAGGGERMVAESRSLAASQARAARSLARWSAVRVLALALCGRFPPLLLLLGSPWL
                     LRDGLTPGALVGALTYLTQALAPAVQALMTMLATVGGRLVVVLDRFTDAPPPPEPDHEA
                     ARPAQVNSEAQCPQPADHTRPDTPGRAGPDRRARPRSPVAELREVTFAYGPAAQPVLDR
                     LSLRIGRGEHLAVIGPSGSGKSTLAAVLAGVESPTRGEVRWHGRPVHRDDASSVRVLLP
                     QRAYVFTGSLRENLCYLRPDARECEIAAMIDALGLDPLLSRLGSLDAAVAPALLSQGER
                     QLIALGRAYLTHVPLLILDEATSRLDPSAETRAELAFAARPGALVVVAHRLSSARRAGR
                     ILVMDGARTQCGTPTDLLRDSALYRDLNGLWAPEQPERP"
     gene            complement(17296..17901)
                     /locus_tag="A6A29_RS23905"
                     /old_locus_tag="A6A29_39075"
     CDS             complement(17296..17901)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006127364.1"
                     /locus_tag="A6A29_RS23905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_39075"
                     /product="response regulator transcription factor"
                     /protein_id="WP_073722661.1"
                     /transl_table=11
                     /translation="MTDVLLVHAVPLWRASLASLLRAAEGIDVRTAERGAIRAALTGRC
                     PDVFLTDLDCPDAMDVLQEVEPLTGADGRPCPLAVLTRGDRPRGLRRAYEAGARGYIDK
                     FRPVDDLAEVMHKLADGGRHIDESLAFGLLQVADMPLSPREVSVLALAESGESVAGIAA
                     RLNLTAGTVRNYLAAAIRKSGARNRQDAIRLAKSAGWI"
     misc_feature    complement(17479..17481)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            18313..18798
                     /locus_tag="A6A29_RS23910"
                     /old_locus_tag="A6A29_39080"
     CDS             18313..18798
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014180500.1"
                     /locus_tag="A6A29_RS23910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_39080"
                     /product="hypothetical protein"
                     /protein_id="WP_073722662.1"
                     /transl_table=11
                     /translation="MTFDQEWAGLVSEAKERQSVGMRLNTGETPPGTPGAGSSYDLVVT
                     QDDLGAVGNQAFLLHAELRKKADIAGVGSDAGGAGSTAQAAKELSAHNMTMGDELYTTL
                     SVWDSQVKTVLQMCAHISNHLNYSKKSHAKDDELIEASMRGRDGSPMPVSELSKYVS"
     gene            18829..20322
                     /locus_tag="A6A29_RS23915"
                     /old_locus_tag="A6A29_39085"
     CDS             18829..20322
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018492168.1"
                     /locus_tag="A6A29_RS23915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_39085"
                     /product="hypothetical protein"
                     /protein_id="WP_241838632.1"
                     /transl_table=11
                     /translation="MFTYRDLVEMDLGKLGTAVGGWKTMADELGKLRTEVYDGLVPMSD
                     SAKWEGVNATVTKDFVRGTAKEFLDLHAEAQSIHRVLEDAHAELTHIQKQVISLAEQAK
                     GGDATEHAPPAPLMVSVGYGGVVRVTELRCTPEPASQRTKDLMQWYADTITGLVAHAAE
                     IDGATTRALKASHGGDPLNAGHAAYTSLDEDQLPRAMNLASLGGKATDPQRGELRRLWE
                     SLSPTARGELWMARRDDLLAAGLLDPTVKRAAPDAGSGPYDVKSPGFKDRWTREKMKMI
                     VEGADFGGLDNASLHMAHYLDNDGDPLKLPVDKMMSDDKDFEAHIGKTVVEQGAVWREQ
                     ALEEFRRNGGRPVAIPVETGNDDFSFAQDKDKNWFYAVGSTRSNVTGVVTVVPDVNGQP
                     SVRLDYQANVWDRYNWDKDKGVTILGMGVPDGEMAKMHTTGLAQEFDMSGSSSVKQYDL
                     GGSAPNEQPPPAPDEPGRDNTREDPGRDQRGVRDDGGHR"
     gene            20448..21023
                     /locus_tag="A6A29_RS23920"
                     /old_locus_tag="A6A29_39090"
     CDS             20448..21023
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009715077.1"
                     /locus_tag="A6A29_RS23920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_39090"
                     /product="hypothetical protein"
                     /protein_id="WP_073722664.1"
                     /transl_table=11
                     /translation="MRRPVVVLSGVLLAVAGGVVAVAFAVQNALSDRVDQEENCCWSSG
                     VTPAWMSEQIGIGIPAAASDRRAGYKTGERYDVGLLVFTLPTKDVDAYLLPLRPKGTEM
                     IPNLYPEQKGYKATAGFSHLGLVEPETLIEGLREGGFCPGDVESPYGKDVQYCVDLFAH
                     AYEPGRTRVYIRSTIESGVTPPPAVPTT"
     gene            21591..21998
                     /locus_tag="A6A29_RS23925"
                     /old_locus_tag="A6A29_39095"
     CDS             21591..21998
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007512669.1"
                     /locus_tag="A6A29_RS23925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_39095"
                     /product="YciI family protein"
                     /protein_id="WP_073722666.1"
                     /transl_table=11
                     /translation="MAKYLLLKHYRGAPAAVNDVPMDQWTPEEISAHVQYMNDFAARLE
                     TKGEFVDGQALAPEGAWVRYDGEGRPPVTDGPFAETKDLIAGWMIIDVDSYERAVELAG
                     ELSAAPGAGGKPIHEWLEVRPFLTAPPTITE"
     gene            22007..23152
                     /locus_tag="A6A29_RS23930"
                     /old_locus_tag="A6A29_39100"
     CDS             22007..23152
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010049069.1"
                     /locus_tag="A6A29_RS23930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_39100"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_073722668.1"
                     /transl_table=11
                     /translation="MNEALLRSLTPSVLGILVRRGADFAAAEDAVQDALVEALRVWASD
                     PPRDAKGWLVTVAWRKFLDATRADAARRRREDRVEGEPEPGSAPAVDDTLQLYFLCAHP
                     SLTPASAVALTLRAVGGLTTRQIAEAYLVPEATIAQRISRAKRTVSGVRFDRPGDVATV
                     LRVLYLVFNEGYSGDVDLAAEAIRLNRQLAAAIDHPEVAGLLALMLLHHARRAARTASD
                     GSLVPLAEQDRGRWDTALIAEGVGILQAALARDRLGEFQAQAAIAALHADAPTAEETDW
                     VQIVEWYDELAHLTDSPIVRLNRAVAVGEADGPRAGLAALTALEPSLPRHAAVAAYLHE
                     RDGDLATAARLYAEAAHKAPNLAERDHLTRQAARINARRCH"
ORIGIN
        1 gaggtgggtc agttttgatc cgctgtcaga gggtcacgat tcacccgtcg ccgacaggca
       61 cggcttcgtg ggtgccgagg acgtggttgc gggcgaatcg gagacagcga cgcgggcgcg
      121 ggtgcacgag tccctgagcg ccgtgcggga ggcgttcggg ctgccgcagg agcctgccct
      181 gagggacgtg accgtaggca tccgcccgat cccgaccggc aacggcatac tctgcgcacc
      241 gctggcgaat gctccgggag tcgtcgcact tgccgcgcac cccggtgtga cgctcgcggc
      301 ctcgctggcc cagcgagcgg cggaacacgt cggcgacccc gatccccgat ggcgaaggga
      361 tgatgtggga gccgaggaat gaggcgtggg agacgaagct cgccgcgctc cgcagcttcc
      421 accgccacca cgggtacctc gcaccacgga aggacgcggt acggggcgaa gccgaggacg
      481 aactggtcgc catcgggcag ctcatggcga acctgcacct ccacagtccc acgtaactca
      541 ggtgcgggaa agcaccgaga ttgaggttgg gagctgaacg gcccggcccg cgactgacct
      601 ggtctgcgga cgggcaacga caagggaacg caacacggcg tgactcgtgg ccgccgcaga
      661 gtgggcggca gcaacctcgg cgactcctcc accgcccagc aggtggcctc cggcttcggc
      721 gcctcgaacc cgaacaatgg cgcgcagtcc aacggctccg gcttcaccgc cctcggggag
      781 tccaactccc acgagtcgct ggtctggaac cctctcccgt agcgaccgtc cccccagcaa
      841 caccggcaca caagttgagc ccgtcctccg caccagaggg cgggctcacc cacgttcgcg
      901 tgggcgtcgg acactgtccg agtagctgcg ccacgtacgc gtggtccgtg gacgctcctg
      961 ggtacgcggc agttcagacg gcccgggtgg cgagcgcggc ttgcggccgg tcaaggggtt
     1021 cgctaccaca cccgcaccgc agcggcccgg acccagggcg aaccctcagg cgtcatcgcc
     1081 atggtcaccg cggcaaggcc attgatgccc tgatacgcca gcggttccgc cgcttctacc
     1141 tgcttcgtga cgccggtgga gtggctgacc ggcatgaaga cgcaggtcgc gtccatcaac
     1201 ccgacgggac cagcgccagc gcctcgttca ggtgatgctc ggcgatcccc cgcatgaact
     1261 cccggtcggg gaagtccccg tcgagcaggc gcagcgggcc ggctgtcagc gacagatgct
     1321 gggtgagttt gtagagtgcg aggcggtcct cgtcgaggcc atccaccgcc agctgctggt
     1381 actggctgtc ggaatggcgg aggcgtagga acacgtgctc ccattcgaca tcgaagtaca
     1441 gcaggttctc gatgtcgatc acgacgggat ggccgtcccg gtcgaccctg acgtggtcca
     1501 ggcccagctc gccgtggacg acggagtact cggcgcgcgg ccgcaccgcc gcggtcagct
     1561 gacgcagccg ctcctccaac tgatcgcggg cgtcggcgat cctgtggtcg cgcgcggtcg
     1621 cctcggcgag gcagcgcagc gcgaaggcga gcgccgcctg ctcgcacgag gccgagcgtg
     1681 acgtgccgcc cgcgtcgatc agggccacct tgccgaagga ctgtgcccgg tgaccgcgca
     1741 tcgtcgccag gctctcagcg aggcgcatca tggtcggctc cgcggcgcgc gggtcgcggt
     1801 tgcgcaggcc catcaggtcc tccccgggca cgtcctcgac gatcgcgagt tcggccgggt
     1861 agtgggtacg gtcacggtcg gccagatgga tctcaaggac ccgaaggccc agcgcctcca
     1921 ggcgcgcgtg cgcggcctcg aacaggtcga gcccggtacc gggcgagaac ggatcagcga
     1981 ggtcgccgtc gtgctcggtg gtcggccagt agttctctga gtcctcccac aggtaggcga
     2041 tcgccgtcct ggcgtcgtcc atcgtcagcc ggtacacacc cttcgtggtg ccgcccgcaa
     2101 gtcgctcgac cgcctccagc cgtcgcccgc cgcccagcgc tgcccgcgcc gcacccgcca
     2161 actgatcccg cgtcactctc ttcggcgcca cgccgcagcc cgccttcctc atcgatgact
     2221 ggggcacctt acgcgagccc tcgttcaatg ccgaacgaat ttcaccgcag gtgtcatgcg
     2281 cgatatagga ccaggcgcca ggcaacgtgc caccccatgc gctgacgtca taaacgctgc
     2341 tccctgtcac gtacagagcc agagatggct gtacgtgaga tcaagttgct catgcctgcc
     2401 ttggttgctc cgccggtgcc cgtcggttgt ctcgccgcgt ctgctcaacc gtccttgccg
     2461 aggtcggaaa ggccgccgga cacggctacg cagatccgcc cccggtcgac tcgtgtacgt
     2521 gctgcggcat cgactgggcc gtgggtagat ccggccggcg gttcatacgg ctctccgttc
     2581 acgctgctcc tcgcggtgag cgagccgccg cagctccacc cgggcggccg ggatccggtc
     2641 gggattcggt cgggcggggt gaacccgaac ggataccact ggatccggga ggacaggtcc
     2701 gggaggcgac ggcgcaggcc tgtcggcgat ccgtaggcga tgtgtcggtg gccgctgaaa
     2761 ccatgggtgc cacttgccca acggggcagt cccaaccccc ttcaccagca caggagcccc
     2821 ctcgccatgt cgcccacgcc ctccactccg ccctgggacg tccgacggct gcctcgtgcc
     2881 gatgacagcg tcttcctggt caccggcggt aacgccggca tcgggtactt cgtcgcggag
     2941 cagttgtcgg caaccggagc caccgtcgta ctcggcagcc ggaaccccga caaggccgag
     3001 gccgccatgg cttcgatccg tgcgcgtgtc cccggcgcac gggtgcgggc cgtccggctc
     3061 gacctcgccg acctctcatc gctcgaaaca gcggtggaat cgctggaggt ggaatgtctc
     3121 gacgctgtgg tccacaacgc cggcgtcgcg ctcgacgtcc cgccacgcag ggagaccggg
     3181 gacggtcacg aactcatgtt cggcacgaat cacctggggc acttcgtcct gacccagtgg
     3241 ctcatgccgc tgctgtcggc tgcgccggcg gcccgcatgg tgaccatggg cagcttcgcg
     3301 gcgaagtccg agcggctcga cctggacgac ctgcagtccc acaaggacta ccggcccaag
     3361 cgcgcctacg gacgctccaa gttggcgcag atgtacttcg gcgtcgaact ggaacgtcga
     3421 ctgcgcgccg tcggcagcac ggtggcgagc gtggtggtcc atcccggcgg cgcgctggat
     3481 tccctcaccc cgtcacgacc gccggtgcat gtgcgcaata ccggcgcgcg tctgagcgcg
     3541 gcacctgcgg ccctcctcct ccagggcaag cacgccggcg cctggcccgc cgtccgagcg
     3601 gtgctcgacc cggccgtgcg gggaggccag ttgtggggcc cacgcgtctt cggtctgcgc
     3661 ggcgagcccc gacgcgaacc gctgtggacc cacctcgccg acacctccgt cgcggcgcgg
     3721 ttgtgggacg caagctgtga tctgaccggc ctcgacctcg gtgtcgcccc cggatagtcg
     3781 cagccacgcg cgttgaccaa caggcatggc tgcgaccatc ccccactaca gcgctccgtc
     3841 gcagaacaaa tgactcgcct gccggtcggt gccgccctga tcgcatgact gaagtgcagt
     3901 agcggcgggt gtacggctgg gtcggcgatg cggcacagcc cgcgtcggaa gcactggatg
     3961 aggtgctcag cggtggcgat gttggggagc cggcctcggc ggagcgggaa ccagatgcct
     4021 tcgacgggct gtcctccaga agttgcccat gtcatgtgcg catgaccaaa ccaccccatt
     4081 cgctgccatc cactccacac cggtgtccac attgggcgcc aatggataaa ttaggagcga
     4141 tttgccgaga tacaaatatc tatgaattcg aaacgtgaat gagtcaattc aggaagtgac
     4201 gtgagtcact tgacacgttc atcgaacagg tctttacttc ccacggcagt tgaaatgaag
     4261 ccgggaattc ttcccggtct cgacttcttc tgtcgccgaa taagtagctc gttcaccact
     4321 aaaatggagg tgctcatgaa gctcgttcgc atcatcaata agttccgccc ggaaaagagc
     4381 ctcaaggcgt acgcctggta cggctggatt taatcaggta gtttccctgc cgggctcgcg
     4441 ccggtcagga attctggtcg gcgcgagcta cctacccacg gagttcaccc atgcctatgc
     4501 accgcgttgg cgggagcggt cgtgtcatcg agtttgcacc gagaatcgac gagctgctca
     4561 ctcgttatcg cgatgcatcg ctgttccgtc tggagcccga cacgatcggt atatccggcg
     4621 ccgatctgat ggacggcttg ctacgaagca ggccggccaa tgcggaggaa aggcctacct
     4681 tcaaacccgt ccagaggcgg ctcgtcggac gtgccgatgc ggccaccttt atgcaagcgg
     4741 tgggctcgga cgtgcgaaac gcgttgcaac gtcccctcga tgacacggtc gacctgaccg
     4801 gccggtggcc gcatgtggcc catgtgtacc tgcgggatct cgtattcgga aacgaacgtc
     4861 tgcgattccg ggttctggtc gaccgccgac tggagttgac accgaaactg acctggtcgg
     4921 ccgtcgcctc cggtgccgct ttgctgggca ggcccgggca ggacgtgccg ctgtcaaagc
     4981 ttgccgctct cgttctcgat tccaagagct acagtgaccg gcgctatgcc atgtacctgt
     5041 accggcgggt ggccgcaccg gtgtgcttca ccgtatccgc gcttgtcacc aacgccctgt
     5101 ggctgggggc tcctttcagc gacgacgtgt cgaatcggaa catcatcctt gaggcactcc
     5161 ggctgcttcc cccttcgtgg aacatcttgc gaatggcttc gccggagttc tcggacgtgg
     5221 acgcacggat cggcccgaaa gacgatgtcc tgctgcttcc tctgctgagc catcgcaacc
     5281 ccaagctctg ggacgagccc gacgcgtttc tccccgaccg ctgggacgag ctggacgggg
     5341 aaacacaccc cggctatctc cccttcggtc acgcaagcga acgatgctgg ggtcggcata
     5401 tggtcctgcc cctggccgaa cggctcctgg acattgtgcg ccgggacggt ctcgtggtga
     5461 gtccggacca gaccaggggg aaggtcgaac tcgacggatt gctcgaagtg tccgaagtgc
     5521 ggatgactcg accgtgacgg tcctggaacc tggcggcata tccgcagtgt gtccgcccag
     5581 gtaatcgcac gcagatactc acgttgacct cgtggagtcg tacgggctga cgactggacc
     5641 caccaggtcc cggctcgccg tgcggtaggg gctttgaccc ccagatctcg gtcgcttgag
     5701 acgtggacct tgagggtctg agaacggaca ggctgtggtc acgaagtcct gcccgccgga
     5761 gttcacggcg gacgcggcca cgctgtacgg gtcgcggcca ggagcgacca ccaggtcggc
     5821 cgccaccgac ctgggagcaa cccggaaggc tgcggatcgg gagccggcac cctactgggt
     5881 acgccgtcgc cctggcgcgt acggctatcc gcccgctcca gccacggtgg cgagttcatc
     5941 gagcagcgcg gcgatggcgg cgtcggtcag ccgaaagccg tcggcggtct cgacgatgtg
     6001 gcccgaggcg atacgggact tccaccactc ttcgaggaag ccgggggcgt atccgcccgt
     6061 gcggaagccg tacggctcgg acacgaggtc gaaggcgatc atgagctcgt agtccggcag
     6121 ggcgtaggaa cgctcgtgct ccggaggcgc gctgacgtac cgctcgaagg agtcgacctg
     6181 gttgaagctg gtgaacagcc agaacaggta gtcgtacatc agcatcgagc gcgtgtcggc
     6241 gtgcagggcg aagaacccct tgtcgcgcac gacggtctcc gcgagcgccc gcatgtgccg
     6301 gtcggcgtcg ggcagaacgt ccgcgacctc gcggaaggca cgcaacaggg caggggagaa
     6361 gccgccgtcg cgcaccgtgg ccagggcggc gagccggtcc tgctccgagg tgtcatagac
     6421 ggacccgtcg accaggccag tgacgaacgc ctcgaagttc tccgcgaccg aggtgatcgc
     6481 gaagtcgccc tcctggtcga cgtgcaccac cgtcggctcg ccgtgcctgc cgcacgcgcg
     6541 gtagtcgagg gcgagcatgt cgtggccggc cgagggggtg tcggcgaagt agacaccgat
     6601 gtcggggtac tcccacatgt cgatccagaa caggctgccg tactcgccgc cgagcgattg
     6661 cggtcgggtc cgcccgatgc cccggatacc ggtgatctcg atgtggtcct cggcccagga
     6721 cgtcggctcg gtcatgggga agtggacacg ggtcggaatg ccgccgttgt gcgcggtcat
     6781 cagcgcgatg tacgagccgg gcagacggta tccgccgagc tcctcctcca atgacgcgat
     6841 caactcccga gaggacgggg cctcctccac gtactccccc agcgcgtacg ccgagtcatc
     6901 ccagaacccc gcgacgtcga agccctcgaa gtaccccact gcgccctccc gcacctactc
     6961 gtccggcgat tctatgttcc gctcccagac gcgaccgcgg ccgcccccga gctcaccggt
     7021 gcatcggcat cgctccgatc accggaccgg aaaggcttca gagcctgggc cggaggagcc
     7081 cccgtagccc atgtcgacgg cgactcgccg gatcagttat tcatgctgtg agggtctcgg
     7141 gtcgtacgac gagtgcgccg cgtgcgaagt gggctcggcc aagggtgacg aggtgaggtg
     7201 cgttcactgc tcgccatccg gcccgatgcg cacctcgtcc ggtcccgtcc gggcagggat
     7261 caccgcccag caagggatca cggaacataa tgctgcccat gagcgactcc gcagaccctg
     7321 gtgacaccgg tgacaccggt aaaggcaaac cgttgcaccg cctggtgcgc atgacgggcc
     7381 gtaacccgga ggaacacgga cggacctcca ccccgttgga gctcctgttc gacctcacct
     7441 tcgtggtcgc ggtcggtaca gcggccgacc acttcgccga gatggtggcc gaggggcacc
     7501 ctgggcaggc ggtcaccgcg ttcgtcctgg caatgttcgc gatcagcgtc gcctggatca
     7561 gcttcagctg gttcgcctcc gccttcggca ccgacgactg gctctatcgc atcctgacga
     7621 tggtgcagat gatcggcgtc gtcgtgttct cgctcggcct gcccgcgatg ttccactccg
     7681 tcgatgaggg cggacacctc gaactgcggg tcatggtgat cggatacgtc gtgatgcgca
     7741 tcgccatgct gctccaatgg tggcgcgccg cccgcgactc ccccgccttc cacgacgtcg
     7801 gcatggccaa catccgctgg accgccatcg tccaactcgg ctggatcgcg gtcgctttca
     7861 cccatctccc actggccgcc gtgttcaccg ccttcgtcat cctcggagcg ctggaactgg
     7921 cactgccgct gctcacccag ggcagcgcgg acggcacccc ctggcacccc caccacgtcg
     7981 cggagcgcta cggcctgttc gcgatcatcg tcctcggtga gggcgtcgtc ggcaccgtcg
     8041 cctcctcggg cggccttctg gggggcgcgg acggaatgca ctggagcggg aacgggatcg
     8101 ccgtcgtcgt cgccggtgtc ggactgacct tcggcatgtg gtgggtgtat ttcgccaccc
     8161 ccttcggtga cgttctcgtg caccgccgcg gccgcggata cctcttcggc tacgggcaca
     8221 tccccctgtt catcggaatc gccggcgccg gtgccggact gcacgtggcg gggctccaac
     8281 tggagcacca ctccgagctc agtgatgtcg ccgtggtcct gtccctggcc atcccggtcg
     8341 gcctctacct gttgatggtc tatctgctgc acacccttct gctgtccgcg gcagaccgat
     8401 tccatctgct cctgatctct ctcactcttg ttctgctgct gacggccgtc ctgctgtccg
     8461 cagtcggcat cgcgatcgcg gtgtgcctgc tcatcgtcat gctcgcgccc ttcgtcaccg
     8521 tcatcggcta cgaaacgatc ggccaccgtc accagcagcg gatgctggag gcactcggca
     8581 cgcacacgct gagccgttga gccgttgagc cgttgagccg ttgagccgtc ggaagtccct
     8641 accccagcga ccgtccgacg cccggttggg ccttgatcac cgacagtaga cttccgcgaa
     8701 agccatgcga aggcgtcttg gcgtcggcgg ccggccccaa gctctcggga ggctggtcag
     8761 ccgcctgtcc cggggatcaa tggctcgggc acaatcagca gccatgccta cctctcccga
     8821 tcccgcgatc ctgtaccccg acgtcgtcgg cttcggcagc ctggccgcag ccctcagggc
     8881 agcggcggag ggctgcctcg ccgacgtccc tgtcactgcc tcggtctctg atcccctccg
     8941 ccacgcgacc gtcgcaagca ccttgccgca ccgcgagcca ctggagatca gcgcttggtc
     9001 gcacgaacgt cggtggtcga tccggggcac cgagccgttc cagagcatgc ctctcatcga
     9061 cggcaggacg gacgtcctgg cggacatcgc cagggccacc cgggcgtggc acgacgggct
     9121 gttcctggac gacattcgcc gggcggctcc cttcgtccac ctgaccggcc ggttcgaggt
     9181 gcccgacaac gatcccgcgc gcttgaccga gtccgagtgg cagggcctgc gccaggaggc
     9241 ggccgagctg gagtacgtct ggcaggagac gcaccagtcc ctggtcgaag cggcccacgc
     9301 cgagccggcg ttgcgcgccc tctacccgtt caccagccac tgggcactgc gcttctccac
     9361 ctccacccgc ccggatctga ccgtcgtcgg accacgcctg ggcgcgaacg ccgacggcac
     9421 gtacggggtg ggcagcgtca tgatcggcca ggacatcggc caattcgcca cagcgcagga
     9481 ggccgtggcc gtggcagtgc gcctgctgcc gtccggtctc ggtcccacca cgctcggcgg
     9541 atgatcccac cccgcaacgg cccggccgac catggaggcg ggcggatcgt cgccgaactg
     9601 aagtggtgcg tcacgtagat gatcgccaag cggcctcggg ctccccagcg taatcggtgt
     9661 gtcctacggt actgagggac agtatgatcg gccgcgtgaa gctcctggag attcagcacg
     9721 tggacgccga tgtcgacttc tacggcctca gcctccagga cgccgatgat ggctggctgt
     9781 cgacaacgct ccccgagggt ttcgcccagg ggcggtttct ttcggaacag ccggggcgta
     9841 tcgacttcac gagcgccggg cacacgcaga ccgtgtcctt cgacgccgag atctggagcg
     9901 gtcccgctca agtgcccttc ggtgagtggg acgagtccgc gaccgcccgc atcgagtgcc
     9961 gctccggtga actacggctg tgggctgtgg cgggcgggcc tgcccctcga agcatcgttc
    10021 tgccgcacgc gtcggcgaca tggaacgtgc gcgtccgttg ccggggccgt gcggccgcgg
    10081 caagggcatg tcgtgtcggt gtccctcatg ggctggagca gtacctggcg cagttctggc
    10141 ctgtgtgatt ccggtgtggg ccgcctgctg cggaccatac ccgcagcact ggtcagccgg
    10201 tgatcttgat catgtatccg tcgtcgggtc cgccgagcag gcggtgcttg gtacggcact
    10261 gcccgagcgg gttgccggcg ttccccttct caccgagccc tgcttgcatc cgtcggccga
    10321 tgcgcccttg gcgggcgact ccccggagtg gaccgcgggc tgacgccggg accgatgcgg
    10381 tccgacgacc ggaggcaccg ttcggacgcg tacctgcgcc gggaccaggc cgttcgcaag
    10441 gcgccgcaga cctgcgagcg gcgtccgcag tagcgcgtgc accgaagcac ggtgcgcttc
    10501 gcatatctcg tacgcacgtg tgagtgatga caatggtgac tattggcgcc caccgtcgtt
    10561 gtgacaactt ctctctcgcc aggaaagaac tgagcgaggg gaacgtgcgt gaatccggag
    10621 tacgccgcgt actgccaggc ggaccgccac ttctacgacg caccgcaccg ctcggtctcc
    10681 cggccggaag aggaccgcac gttctatgta ccggtccgcg gcgacgctcc cgaggggtgg
    10741 agccgctcac ggcgcgggga ctggctctcc tacgccccct cggacatccg gctgccctca
    10801 cagggctgga agatccatgt gtccgccgcc ctggacaacg ccgaatcggt gctgcgcagg
    10861 gtcgtcgagc actgcctggc gcagcggctg cctttcaagt gcgtaccgac accgaggctg
    10921 ttgcacctgc gcaacgccaa gtacgccgac cgggcgggca gcggcaagtt catcaccgtg
    10981 tatccgccca cgccggaacg gtttccggag gtgtgcgccg cgctgacgga actcctggcc
    11041 ggggagcacg gcccctacat cctcagtgat ctgcggtgcg gagacggacc cgtgcacacg
    11101 cggtacgggg cgttcgccgc ccgcttctgc cccggacccg acgggcggcc ggtacccgcc
    11161 gtcgcggacc cgcagggccg tctcgtcccc gacgagcggg ggccgtcctt ccgcgtcccc
    11221 ggctgggtga caccgcccga cttcctgcac ccctacctcg aagcacgggc ttcggtcggg
    11281 ctcacggggc tgccgtacac cgtggagaag gcccttcatt tctccaacgg cggcggcgtc
    11341 tacctcggcc gggacacccg cagcggtgag caggtcgttc tcaaggaggc ccgcccgtac
    11401 gccgggctgg cggccgacgg agccgacgcc gtcacccggc tcgtacgcga acggaccgcg
    11461 ctggaacaac tggcgggcct ggactgcgta ccggctgtcc gggacgtgtt cgaggtcggc
    11521 gaccaccact tcctggtgct ccagtacgtt cccggctccc cgctcaacac ggtcttcgcc
    11581 catcgcttcc cgctgtcccg gcagaatccc acgagcgaac agctcgccga gcacgtggcg
    11641 tgggcggaac gggtgtacga ccaggtggag cgtgccgtcg aggcggtgca cgcacgtggc
    11701 atcgtcatca gcgacctgca catgagcaac gtcatggtcg acgaggagac gtcccgcatc
    11761 gtgctcctgg acttcgaggc cgcgtcccgg accgaggagc gggcccgcca gatcgtcgcc
    11821 aacccggcct tcgtcgcccc caccgaccgg cgcggcaccg atatcgaccg ctacgcgctg
    11881 gcatgcctgc ggctcgcact ccacctgccg ctcaccacac tcttcgccct cgaccgcacc
    11941 aaggccgtcg gcctcgcccg gaacgcggcc cgcgtcttcc ccgtcgacga gcaactgctg
    12001 cgccctgcgg tggacgagat cctgcgcacc acgggcgatc cggcggggcc cgcgggcccg
    12061 gcggaaccgg accggcgccc gcccgcgccc ggggactggc cgcgcagccg cgactcgatg
    12121 gcccgcgcca tcgcggcctc ctgcacaccg gagcgcgagg accggtgctt ccccggcgac
    12181 atcgcacagt tcgccacggc ggcgggcggc cagtcgttcg gctacggggc cgccggagtg
    12241 ctctacgcgc tgcacgagac gggcgcccgg cagtgcgagc ccgccgtcga ctggctgctg
    12301 cgccgggtca aggacccggc ctccggcacc ccgctcggtt tctacgacgg actcaccggc
    12361 atcgcctgga ccctgaaccg gatcggccgc cccgcggaag cctccgacct gatccgggtc
    12421 gttctcgaac agcccctgga gggactgccg gccggcctgc acagtggtta cgccggtatc
    12481 gcgctcgccc tcgacgacat ggcccgtacc gccgccgtcg acggcccggc cctcagcgcg
    12541 gcggcggacc gctgtaccgc tctcgccgtc cgcgcgctcg tggaggatcc cccgtcaccc
    12601 cggaccggcc tcatgcacgg cgctaccggc gtcgccctgc tgctcatcca tcggtacggg
    12661 aagaccggcg acaccgccct gatcgacctg gccgccgccg cgctgcgtcg tgatctcgaa
    12721 cggtgccggg cgggcgacgg cggactgctc gtcgtggagg ggaaacggct gatgccgtac
    12781 ctcgcctcgg gcagcatcgg catcgcagcc gtcatcgacg cctacctcgc ccgacgcccc
    12841 gacgccgccc tggaggccgc cggccgcgcc ctgctcccga ccgcgctgtc cgccttctac
    12901 atccagcccg gactcctgcg cggatcggcc ggactgctcg cccacctggc ggccacaccg
    12961 ctcctggaag ctccggaccg tgcgcgggcg atccgcctcc acaccgacct gctggaaagc
    13021 cacgccatgt cgtacgaagg tgaactcgcc tttcccggcg agcagttgat gcgcctgtcg
    13081 atggacctgg ccaccgggac agccgggtgc ctgctcgccc tgggcggcgc actcgggcaa
    13141 ccggccacgc ttcccttcct gccgctcgcg cggcacaccc tgccgcgtta gcggccccaa
    13201 ggaccggccc catcaggggt cgtcgcagta cacgccgaca caacagtccc tgagaaagga
    13261 catcatcatg gcacttctcg accttcaggc gatggagacc ccggccgacg aggccttcgg
    13321 cgagctcgcc acgggcagcc aggtctcgct cctgatctgc gagcacagct cgctcagcct
    13381 gaccctctgc accccgtaat gccgggccgt ccggtccgcc ggtgatccca ccggcggccc
    13441 ggacggctgc gggtgtccgg cggtccgggc cccaagacgc ggagcccgcg ccaccggaac
    13501 ctgcgacaga ccgggcccga tgccgccgag ccctcagggc tgtcgtcgta ccgcccgaag
    13561 ccggaaaggg acccacgtgc ggccgaaccc acccgccggg gcggctctcg cccccgtacc
    13621 cgaccggccc cgaaaagctc cccgggaacg tgccggccat tcgccgccgc cctccggagc
    13681 ccgccccctc gaactcgccc ggctgcgccc ggccgccctc gtgtgcctgc tgctgtgctc
    13741 caccggcggg acgctcgccg ccctcgccct ccccgccgcg ctcggccaca ccgtggaccg
    13801 gctcatcgtc ggcggccccg tgccctggtc cggactgctg ctgtgcgcgg cgctgaccct
    13861 cgccgagacc gcgtgcgatg cgggtgcggc ggtggtcggg acgagcacca cggcccggct
    13921 gaccgcggcg ctgcgcaccc ggaccgtggc ccgcgtgctg gccgccgaac cccgccggac
    13981 gctcgatgtg cccacggggg acctcacggc ccggatcacc acccaggccg ccgacgccgc
    14041 agccgcgccc actaccgcgg ccgggtccgt cgcgggagcc ctgctcccgg tcggcgcggt
    14101 cgtcggactc ctgctcatcg acccgtggac ggcggccgcc ctgcttctcg gcgcccccct
    14161 gctcatcgcg ctgctgcgca ccttcacccg ccgcaccgcc gacgcgaacg ccgactatca
    14221 gcgggcgcag gcgctcatcg ccgaccgtct caccgaggcg ctcgacggcg ccgaaaccat
    14281 ccgcgcggcc ctcaccgggg cacgggagta ccggcgcgtc ctcgaaccac tcggggcgct
    14341 cgcggagcac ggacgccgca cctgggccgt gtacggaaag gcgtccggcc agagcgccct
    14401 gctgctgccc ctgctcatgc tgctggtgct ggcggtcggt gggctgcggc tcgacgcggg
    14461 cgcgatcggc gtcggcgacc tggtcgccgc cgcccgctac gccggcctgg tggtcggcat
    14521 cggctcgctg acgggtgcgc tcagctcgct cgcgcgcagc cgggcggccg ccgaccgcct
    14581 cgatcccctc ctggccctgc cgcccgtgcc gcaccgctca ctggggccgg tggacggcgc
    14641 cccgggaaag ctggaactgc gcgacgtggg cgtcggacgc gagggacggc cgctgttgag
    14701 cggagtcggc ctcgtcgtcc ccggcggctc ctccctggcc gtcgtcggcc gctcgggctc
    14761 gggcaagtcg gtgctcgccg cggtggcggg acggctgatg gacccggaca ccggcaccgt
    14821 actgctggac ggcgtccccc tggacggcat ggagccggac cgcctgcgcc gtgaggtcac
    14881 ctatgccttc gcccggcccg ccctgcccgg ccgcaccgtc ggggagaccg tcgccttcgg
    14941 ggcccgtacc gcctcgcacg aggaggtacg ctccgccgcg cgcgaggccc gtgccgacga
    15001 cttcgtggcg ctgctcccac aggggtacgc cacccccctc acggacgccc cgctgtccgg
    15061 cggggaacgc caacgcctcg gcctggcccg cgccttcgcg catccgggcc gtctcatgat
    15121 cctggacgac gcactgtcca gcctcgatac cgtgaccgag catcatgtgc aacgcgcgct
    15181 cgccgggcga gcaggccgca gcacccgtgt catcgtcgcc caccggctct cgtcggccgc
    15241 gcgggcggac cgggtcgcgt ggctggagga cggccgggtc cgggcgacgg gcccgcacca
    15301 cgtgctctgg gccgatccgg actaccgggc cttgttccgt actgatcctc ccgacgcctc
    15361 cgggctgccg ggaccggagg aaccgtcgtc ccacaacgcc gcccggcccg cccctgcgga
    15421 caggacggcg gaccgatgac ggcgtcccgg ccggcaactg ccgcgcggcg ggcgggccac
    15481 ggggccctga ccagggtggc gggcgacgcg cgccccttcc tgagggaccg caccggcgtc
    15541 cttctcaggc tgtccggctg gtccctgctg gagttcgtcc agaccttcct cggcgggttc
    15601 ggtgtcgcca aggcgctcga ccagggattc ctggccggac accccgcgac aggactgctc
    15661 tggctgggcg tcgcgggcgc ggccacgctg ccggcccagt tcgccacccg ccaggtgttc
    15721 ggacgcctcg cggatctggt ggagccgctg cgcgacggac tcgtacggcg cgcggtgtcc
    15781 cgggcgctgt ccggcgcgct cgcgcagccc ctcggcgtca ccacccgttc gctctcccag
    15841 gtcacccacc agagcgagat cgcccgggac ggctgggcgg gactcgtcct gaccctgcgg
    15901 tccttcgtgt tcacggcggc gggggccgtg ctcggcctgc tggcgctgga gcccggactc
    15961 ctgctcctcg tactgccccc gttgctgctc ggtggcgccc tgttcgccgc gaccctgcgg
    16021 ccgatggccg cccgccagcg cgactacctc gccgcggacg aggcgtacgc cgcgcacacg
    16081 ggggaactgt ccgccgcgct gcgcgacatc gccgctgcgg gagggggcga gcggatggtg
    16141 gcggagtccc ggtcactggc cgcgtcgcag gcccgcgcgg cccgttcact ggcccgctgg
    16201 tccgcggtcc gggtgctggc gctcgccctg tgcggccgct tcccgccgct cctgctgctg
    16261 ctcggctccc cctggctgct gcgcgacggg ctcacgcccg gcgcgctggt cggcgcgctg
    16321 acctatctca cccaggccct ggcaccggcg gtccaggcgc tcatgacgat gctggccacc
    16381 gtgggcggcc ggctcgtcgt ggtgctggac cgattcacgg acgcgccccc gccgccggaa
    16441 ccggaccatg aggccgcccg cccggcacag gtgaactccg aggctcagtg cccccagccc
    16501 gcagaccaca cccgcccgga cactccgggc cgcgccggcc cggaccggag ggcgcgcccg
    16561 cgttccccgg tcgccgagct gcgcgaggtc accttcgcct acgggcccgc cgcccaaccg
    16621 gtcctggacc ggctctcgtt gcgtatcggc cggggagagc acctggcggt gatcgggccg
    16681 agcggcagcg gcaagtcgac gctcgccgcc gtactcgccg gtgtggagtc ccccacccgc
    16741 ggcgaggtcc ggtggcacgg ccgcccggtg caccgggacg acgcctcctc cgtacgggtc
    16801 ctgctgcccc agcgggcata cgtgttcacc ggatcgctgc gggagaacct gtgctacctc
    16861 cgccccgacg cccgcgagtg cgagatcgcg gccatgatcg acgcgctggg cctggatccg
    16921 ctgctctccc ggctcggttc cctggacgcg gcggtagcac ccgccctgct gtcccagggt
    16981 gaacgccagc tgatcgccct gggccgggcc tatctgaccc acgtccccct cctcatcctg
    17041 gacgaagcca ccagtcggct cgacccgtcc gccgagaccc gggccgaact cgctttcgcc
    17101 gcccggcccg gcgcgctcgt ggtcgtcgcc caccgtctca gctccgcccg ccgggccggt
    17161 cggatcctgg tgatggacgg cgcccgcacc cagtgcggga cccccaccga cctgctgcgc
    17221 gattcggcgc tgtaccggga cctcaacggg ctatgggcgc cggaacaacc ggagagaccg
    17281 tgacatgcga ggggctcaga tccagccggc cgatttcgcg agcctgatgg catcctgccg
    17341 attgcgcgcc cccgacttcc ggatggcggc cgccaggtaa ttgcgtaccg tccccgctgt
    17401 cagattcagc cgggccgcta tgccggccac gctttcgccg ctctcggcca gcgcgagcac
    17461 gctcacctcg cgcggcgata acggcatgtc ggccacctgc aacagcccga atgccagcga
    17521 ctcgtcgata tgacgccctc cgtccgcgag tttgtgcatc acctcggcca gatcgtccac
    17581 cgggcggaac ttgtcgatgt agccccgggc gcccgcctcg taggcccgcc gcagcccgcg
    17641 cggacggtca ccgcgggtca gcaccgccaa aggacagggc cggccgtccg ccccggtcag
    17701 tggctccacc tcctggagca catccatggc gtccggacag tcgagatcgg tcaggaatac
    17761 gtccgggcat ctcccggtca gcgccgcgcg tatcgctccc cgctcagcgg tccgtacgtc
    17821 gattccctca gccgcacgga gcagggaggc cagcgaagca cgccacagcg gcactgcgtg
    17881 aaccagcaga acgtctgtca tcaagctgcc ctcagcattt ctctcccgac atgcgcatcg
    17941 cagagtgcga tagcacaggt gcaccgggtg acgagtctcc agtggaacgc ataggcattc
    18001 ccgtacgccg aggaattggc ggaataccgc gtcgacccgg acgcggaagg gggcgtgcgg
    18061 tagtacagcg ggagcgcaca tggtcaaggc gccgtgagcc gaacacctcc gaaagcgccc
    18121 gcgcacgcct ctctccggtc cgcactcccc cggccggttc acgcgccccc cggcatgttc
    18181 acgaactccc ggccaccttg ccctcccgat tccctgcacg cgcacgagga cgtgccggat
    18241 tgatctatcc gaacaccaac tctccgtata ttctgcctac ttcacgtaac cagccggggg
    18301 gacggttcgg gcatgacgtt cgatcaggag tgggccggcc tcgtgtccga ggcgaaggaa
    18361 cggcaatcgg tcgggatgcg gctcaatacc ggggagactc ctcccggcac ccctggggcc
    18421 ggttcgtcct acgacctggt ggtcacccag gacgacctgg gcgcggtcgg caaccaggcc
    18481 ttcctgctcc acgccgagct gcgaaagaag gccgacatcg ccggcgtggg cagtgacgcc
    18541 ggcggagccg gctcgaccgc gcaggcggcg aaggagctgt cggcgcacaa catgaccatg
    18601 ggggacgagt tgtacacgac gctctcggtc tgggactcgc aggtcaagac cgtcctgcag
    18661 atgtgcgccc atatctccaa ccacctgaac tactccaaga agtcccacgc gaaggacgac
    18721 gagctgatcg aggcgtccat gcgtggccgt gacggctctc cgatgccggt gtccgagctt
    18781 tccaagtacg tgtcgtagga cgatcgggct gaagggggcg cagcagcggt gttcacgtac
    18841 agggatctcg tcgagatgga tctcggcaag ctcggcacgg ccgtcggcgg ctggaagacg
    18901 atggccgacg aactcggcaa actgcggacc gaggtctacg acggcttggt gccgatgtcc
    18961 gattcggcca agtgggaggg tgtcaacgcc acggtcacca aggatttcgt gcgcggcacc
    19021 gcgaaggagt tcctcgatct gcacgcggag gcacagagca tccaccgggt gctggaggac
    19081 gcgcacgccg agctgacgca tattcagaag caggtcatat cgctggccga acaggccaag
    19141 ggcggggatg cgaccgaaca cgcccctccc gcgccgctga tggtgtccgt cgggtacggc
    19201 ggcgtcgtgc gggtgacgga gttgcggtgc acgccggaac cggcctcgca gcgcaccaag
    19261 gacttgatgc agtggtacgc cgacacgatc accggtctgg tggcccacgc cgcggagatc
    19321 gacggcgcca ccactcgcgc cctcaaggcg agccacgggg gcgacccgct caacgccggc
    19381 cacgccgcgt acacctctct cgacgaggac cagctgccgc gcgcgatgaa tctggcgtcg
    19441 ctgggcggga aggctaccga cccgcaacgg ggcgagctgc ggcggctttg ggagtcgctg
    19501 agtccgaccg cgcggggtga gctgtggatg gcgcgcaggg acgatctgct ggcggcgggc
    19561 ctgctggatc ccacggtcaa gcgagccgcg ccggatgccg gatcggggcc gtacgacgtc
    19621 aagtcgccgg gcttcaagga ccggtggacg agggagaaga tgaagatgat cgtcgagggc
    19681 gccgacttcg gagggctcga caatgcctcc ctccacatgg cgcactatct ggacaacgac
    19741 ggcgatcccc tgaagctgcc cgtggacaag atgatgtccg acgacaagga cttcgaggcc
    19801 catatcggca aaacggtcgt ggagcagggg gcagtgtggc gtgagcaggc actggaggag
    19861 ttccgcagga acggcggacg gccggtcgcc attccggtgg agaccggtaa cgacgacttc
    19921 agcttcgctc aggacaagga caagaattgg ttctatgcgg tcgggtcgac gaggtccaac
    19981 gtcaccgggg tggtgacggt ggtgcctgat gtcaacggtc agccttcggt ccgtctcgac
    20041 taccaggcca atgtgtggga ccgctacaac tgggacaagg acaagggcgt caccattctc
    20101 gggatggggg tacctgacgg ggagatggcg aagatgcaca ccacgggcct tgcccaggag
    20161 ttcgacatgt cgggcagcag ctcggtcaag cagtatgacc tgggcggatc cgctccgaac
    20221 gagcaaccgc cgcccgcccc ggacgagccc ggccgggaca acacgcgcga ggacccggga
    20281 cgggatcagc ggggagtccg cgacgacggc ggacaccgct gaggcgttcg ccgccgagcc
    20341 ccctgattcc gaccacggct gtccgaacgt tcgtattccg tgcacgtccc cgcatccgtg
    20401 cccgcatcgt gcccgttccc gaacccacaa cgcatcagga gcagtcagtg cgccgtcctg
    20461 tcgtcgtcct ctcaggagtg cttctcgccg tggccggggg agttgtcgct gtcgcgttcg
    20521 ccgtgcagaa cgcgctctcc gaccgcgtgg accaggagga gaactgctgc tggtcgagcg
    20581 gtgtcacgcc tgcctggatg agcgaacaga tcggcatcgg gatcccggcg gcggcctccg
    20641 accgacgcgc cgggtacaag accggggagc gttacgacgt gggtctcctc gttttcaccc
    20701 tgcccaccaa ggacgtcgat gcctacctgt tgccattgag gccgaaggga accgagatga
    20761 tcccgaacct gtaccccgag cagaagggct acaaggcgac agcgggcttc tcccacctgg
    20821 gtctggtgga accggagacg ctcatcgaag ggctgcggga aggcggattc tgcccgggtg
    20881 acgtcgaatc gccctacggc aaggacgtcc agtactgcgt cgacctcttc gcgcacgcgt
    20941 acgagccggg tcgtacgcgg gtgtacatca ggtcgacgat cgagtcaggt gtgacgcctc
    21001 ctccggcggt gccgacaacg tagggcctgc cgaactgcgg ggccggctgc cctccgaacg
    21061 tggaccggcg cgcctcgacg tcgatccatc agccaggaat gccgcgatca tgcgcgttct
    21121 gcgggcggaa ctgggcattg gtccggctga agtcaagtcc gtgccgagtg aggtcctgga
    21181 gggagcccac tcaggcgcga tgcccgagat ggagttcctg gctcgcaggc tgcgggcatc
    21241 cggcatcgat gccgtcgctg ctcggccgta ggacgatgac cagccaagtc cagcgggctg
    21301 aacaactcgt cggcccgagc tcaccaagac gcgccgggac cacacgtaca gtggcgcacg
    21361 cgaagtcgtc tcgtggtgcg gctgttcggt ctctgccggc cctggaacgc ctcgcttcgc
    21421 tccatctcgc cctcgcgcca cggcgtagac ccggataccc gaggcggctc actcgtgctc
    21481 atccacgaga gccaaaacga gcgggcggcg atgtcgagaa cccgtgaccg gctccgtccc
    21541 tgtagtgaac gcggccacca tgggccgcac cagtaccgag gagaaccacg atggccaagt
    21601 atctgctgct gaagcactac cgcggtgccc cggctgcggt caacgacgta ccgatggacc
    21661 agtggacgcc ggaggagatc tccgcgcacg tgcagtacat gaacgacttc gcggcccggc
    21721 tggagacgaa gggcgagttc gtcgacggtc aggcactcgc gcccgagggg gcatgggtcc
    21781 gctacgacgg cgaggggcgc ccgccggtca ccgacggacc gttcgcggag acgaaggacc
    21841 tcatcgccgg ctggatgatc atcgacgtcg acagctacga gcgcgccgtc gagctggccg
    21901 gggagctgtc ggccgccccc ggggcgggtg ggaagccgat ccacgaatgg cttgaggtgc
    21961 gcccgttcct gaccgcgccg cccaccatca cggagtgacc acgcggatga acgaggccct
    22021 gctgaggagc ctcacgccga gcgtgctcgg gatcctcgta cgccgcggag cggatttcgc
    22081 ggcggccgag gacgccgtgc aggacgctct tgtcgaggcg ctccgggtct gggcatccga
    22141 cccgccgcgg gacgccaagg gctggctggt caccgtggcc tggcgcaagt tcctcgacgc
    22201 gacgcgggcc gatgccgccc gccggcggcg tgaggaccgc gtcgaggggg agccggagcc
    22261 cggatcggcg cccgcggtgg acgacacgct ccagctctac ttcctgtgcg cccacccgtc
    22321 gctgaccccg gcatcggcgg tcgcgctcac gctgcgcgcc gtcggtgggc tgaccacccg
    22381 ccagatcgcc gaggcctacc tggtgcccga ggcgaccatc gctcagcgca tcagccgcgc
    22441 caagcgcacc gtctccggcg tgcgcttcga ccggcccggc gatgtcgcca ccgtgctgcg
    22501 cgtcctctac ttggtcttca acgagggcta ctccggcgac gtcgacctcg ccgccgaggc
    22561 catccggctc aaccggcagc tcgcggccgc gatcgaccac ccagaggtgg cggggctgct
    22621 cgccctcatg ctgctccacc acgcccgacg tgcggcccgg accgcgtccg acggcagcct
    22681 ggtgccgctc gccgagcagg accgcggccg gtgggacacc gcgttgatcg ccgagggcgt
    22741 cgggatcctg caggcggccc tcgcccgcga ccggctgggc gagttccagg cccaggccgc
    22801 catcgcggcg ctccacgccg acgcgcccac cgcggaggag accgactggg tgcagatcgt
    22861 cgagtggtac gacgagctcg cgcacctgac cgacagtccg atcgtccggc tcaaccgcgc
    22921 ggtcgccgtc ggggaggccg acggaccgcg cgccggtctg gcggcgctca cggcgctgga
    22981 gccctcactg ccccgccacg ccgcggtggc ggcgtacctc cacgagcgcg acggcgacct
    23041 ggcgacggcg gcacggctgt acgccgaggc ggcccacaag gcgcccaacc tcgccgagcg
    23101 cgaccatctg acgcgccagg ccgcccggat caacgcccgc cggtgtcact gacgggtcgc
    23161 gttcggatcc gtccgcggca cttggcgcgg ccctgtggcc agatcggtcg cttcccgagg
    23221 ca
//
