LOCUS       NZ_LWLE01000016        22234 bp    DNA     linear   CON 27-MAR-2024
DEFINITION  Streptomyces sp. TSRI0281 scaffold23, whole genome shotgun sequence.
ACCESSION   NZ_LWLE01000016
VERSION     NZ_LWLE01000016.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. TSRI0281
  ORGANISM  Streptomyces sp. TSRI0281
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 120538)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 120538)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra,H. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-APR-2016) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2016
            Assembly Method                   :: CLC NGS Cell v. 8.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905125.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:37:03
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,600
            CDSs (total)                      :: 8,518
            Genes (coding)                    :: 8,175
            CDSs (with protein)               :: 8,175
            Genes (RNA)                       :: 82
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 76
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 345
            CDSs (without protein)            :: 343
            Pseudo Genes (ambiguous residues) :: 0 of 345
            Pseudo Genes (frameshifted)       :: 151 of 345
            Pseudo Genes (incomplete)         :: 273 of 345
            Pseudo Genes (internal stop)      :: 33 of 345
            Pseudo Genes (multiple problems)  :: 102 of 345
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:13:17
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 86127
            Orig. end                         :: 108361
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LWLE01000016.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22234
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22234
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22234
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12234]"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12234
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(134..150)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 18.02"
                     /tool="antismash"
     misc_feature    137..146
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.02"
                     /tool="antismash"
     misc_feature    139..152
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.93"
                     /tool="antismash"
     misc_feature    306..326
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.47"
                     /tool="antismash"
     gene            complement(340..726)
                     /locus_tag="A6A29_RS22870"
                     /old_locus_tag="A6A29_38120"
     CDS             complement(340..726)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A6A29_RS22870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A6A29_38120"
                     /product="hypothetical protein"
                     /protein_id="WP_143197044.1"
                     /transl_table=11
                     /translation="MRRFAAVLAGTAALSAVFIPQAVAAPGEIIAPNARAAAEVDFNGA
                     LERQKNVTDSHRVSEGLYCVTVDPSAGINLSSALILANGGPGTTSVSTIGEPTRACDSR
                     RDAITVITLKDGHPASSNFTIAVL"
     gene            1012..1377
                     /locus_tag="A6A29_RS22875"
                     /old_locus_tag="A6A29_38125"
     CDS             1012..1377
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A6A29_RS22875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A6A29_38125"
                     /product="hypothetical protein"
                     /protein_id="WP_073722419.1"
                     /transl_table=11
                     /translation="MASSVWMYGVVSNMSSTSRIDFNTDLSDVGTVATIFTDSNYGGDW
                     QHLRPGSYNRLADAVVVGAVAVDDNTLSSLRVAAGFRFTRYQDPSFAGQQWTFTADTPY
                     VGDDANDQASSIVVTRI"
     gene            complement(1364..1732)
                     /locus_tag="A6A29_RS43260"
                     /old_locus_tag="A6A29_38130"
     CDS             complement(1364..1732)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024751.4"
                     /locus_tag="A6A29_RS43260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_38130"
                     /product="transposase"
                     /protein_id="WP_158074449.1"
                     /transl_table=11
                     /translation="MDTHGWGRRLVLDGVGARLPVRRRSRPCTVVLDNASAHVAKALKD
                     RRDQLAKTGVKLFCLPPRSPELNDIERIWRSAKYEDHPAEPTPASKPSSPPWTRHSPSN
                     RPATKDQQRTVPKPLRSA"
     gene            2507..2905
                     /locus_tag="A6A29_RS22890"
                     /old_locus_tag="A6A29_38135"
     CDS             2507..2905
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A6A29_RS22890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A6A29_38135"
                     /product="hypothetical protein"
                     /protein_id="WP_073722422.1"
                     /transl_table=11
                     /translation="MFSSGMTRVMAWTGAGIGVVATVLAGVAIAAPAANSSQAPYVQAG
                     ALVNADASIVHSKGVKSVTASGHVFCVEIGNEDVDLSRAIITATPRDTAGSTLRVIPSN
                     CAGGKGITVATYNPSGGGMANGFYIAVL"
     misc_feature    complement(2529..2539)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            complement(3001..>3444)
                     /locus_tag="A6A29_RS46815"
                     /pseudo=""
     CDS             complement(3001..>3444)
                     /GO_function="GO:0000150 - DNA strand exchange activity
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012464.4"
                     /locus_tag="A6A29_RS46815"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="recombinase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="GVGVTLVVHEHKRLGRGIDPAALAGDLKASDVGLEFLTGERQGSH
                     GPGGIVFTVLAALSGMKREYIRDRTLESHESARKRGRTTGGTAVADDHVRSMALHPRGQ
                     DMSLRDMAARLVITTGKKKDRRPSPATVMRMLRQHDEKTSTTP"
     gene            complement(3855..4886)
                     /locus_tag="A6A29_RS22900"
                     /old_locus_tag="A6A29_38145"
     CDS             complement(3855..4886)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014414.4"
                     /locus_tag="A6A29_RS22900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_38145"
                     /product="cyclopropane-fatty-acyl-phospholipid synthase
                     family protein"
                     /protein_id="WP_073722423.1"
                     /transl_table=11
                     /translation="MTTTTGASAEDIEFHYDVGNDFYSLWLDDTLTYSAAAWDGITSDT
                     DPGDVAALARAQRNKLRRHLDQAALPRGGRLLDIGCGWGGLLALAAEEDHAGEMTGLTL
                     SRAQLAHVNSLALPQVQARLEDWRFHTPDSVYDAIVSVEAFEAFAGPGLTPGQRVEAYS
                     GFFAACHSWLAPGGTLSLQTIAFDGGIDADGPVGAFFAGDVFPASALPRLTEIAAACDA
                     FFSLTALTSAPQDYVRTLRAWSTRLLAAREQAEKAVGPETYQRYRLYLKTCEILFRRGE
                     VTLYRMTMRRRPQRLHLPARNTNWPQVTQPLPSHPSRELRGALRRGGADVAQLKRTHET
                     VRV"
     gene            5224..5538
                     /locus_tag="A6A29_RS22905"
                     /old_locus_tag="A6A29_38150"
     CDS             5224..5538
                     /GO_function="GO:0000036 - acyl carrier activity [Evidence
                     IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PP-binding (12-60). E-value: 6e-10.
                     Score: 31.3. Matches aSDomain:
                     nrpspksdomains_A6A29_RS22905_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012759.4"
                     /locus_tag="A6A29_RS22905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_38150"
                     /product="acyl carrier protein"
                     /protein_id="WP_073722424.1"
                     /sec_met_domain="PP-binding (E-value: 2e-08, bitscore:
                     27.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADITVQDFDEATLADLVHEYFQVPRDQLHAVATLDELGLDSLAL
                     MELMVVLEERSGMELLDRLKDLSLVSTLRDAAQVIKEAVDASARKAVVSHPAGLPNPAA
                     "
     aSDomain        5260..5403
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A6A29_RS22905_PP-binding.1"
                     /evalue="6.00E-10"
                     /label="A6A29_RS22905_PP-binding.1"
                     /locus_tag="A6A29_RS22905"
                     /protein_end="60"
                     /protein_start="12"
                     /score="31.3"
                     /tool="antismash"
                     /translation="TLADLVHEYFQVPRDQLHAVATLDELGLDSLALMELMVVLEERSG
                     MEL"
     gene            5606..6625
                     /locus_tag="A6A29_RS22910"
                     /old_locus_tag="A6A29_38155"
     CDS             5606..6625
                     /EC_number="1.14.19.2"
                     /GO_function="GO:0045300 - acyl-[acyl-carrier-protein]
                     desaturase activity [Evidence IEA]"
                     /GO_process="GO:0006631 - fatty acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049045.1"
                     /locus_tag="A6A29_RS22910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_38155"
                     /product="acyl-ACP desaturase"
                     /protein_id="WP_073722425.1"
                     /transl_table=11
                     /translation="MTNHPIPPPPVRGHLDLLRELEPAVAHHLDRHLKAASEWFPHQYV
                     PWSSAHDFEGPLGGEPWNSGQSHLPPAVRDALLVNLLTEDNLPSYHHEIATSFGRDSAW
                     GTWVHRWTAEEGRHAEALRGYLHAVRGLDPVELERARMAHVGAGYQSPHPSLAHGLAYV
                     TVQELATREAHRNTGHACDEPHGRRLMTRIAADENLHMVFYRALCADLLDLAPEEFTTA
                     FADVVCDFTMPGHGIPGFQGRAARIAAAGIYDLSVHHHHVLLPLLRTLGVMERTGLRPE
                     GEEALDRIGRHLEDLTDKGKRLANLQDRMRQRTQQTARSTGLEARPRPASDKELEVPR"
     gene            6622..7851
                     /locus_tag="A6A29_RS22915"
                     /old_locus_tag="A6A29_38160"
     CDS             6622..7851
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0004315 - 3-oxoacyl-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (74-405). E-value:
                     2.1e-54. Score: 177.0. Matches aSDomain:
                     nrpspksdomains_A6A29_RS22915_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) t2fas"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543076.1"
                     /locus_tag="A6A29_RS22915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_38160"
                     /product="beta-ketoacyl-[acyl-carrier-protein] synthase
                     family protein"
                     /protein_id="WP_073722426.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 2.3e-51, bitscore:
                     167.7, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="t2fas (E-value: 1.4e-123, bitscore: 405.6,
                     seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGRGDVVVTGLGLITPAGHDADTLWKTMSAGQSLARRDPDLAGL
                     PVDIACAVPDLDPVAELGIRLAGRLDRFAHLGLIAARRALHDAHLDPRTGRPPRVGVVL
                     GVGANSLQTYVKEFTRLGEGRATSVSPLGLPRSVPNMVAGEIAIDTGACGPNFTVSSAC
                     ASGTTAIGVARDLLLGGACDVVLTGGAESARSRMSAASFAQMRALSTRTEHPEGACRPF
                     DADRDGFVLGEGAAVLVLEHPDHARTRGVTIRARLVGYGASADAHHPTSPHPQGAGSEQ
                     AIRQALADAGCTAADVGHVNAHGTATRAGDAAEALALLRVFDTAPPPVTANKSILGHAL
                     GAAGAIEAALTVLALERQEILPTANLTRQDAGREMDIVTTRPRAAAIELALSTSCGFGG
                     QNAALLFAIP"
     aSDomain        6844..7836
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A6A29_RS22915_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="2.10E-54"
                     /label="A6A29_RS22915_PKS_KS.1"
                     /locus_tag="A6A29_RS22915"
                     /protein_end="405"
                     /protein_start="74"
                     /score="177.0"
                     /tool="antismash"
                     /translation="HLGLIAARRALHDAHLDPRTGRPPRVGVVLGVGANSLQTYVKEFT
                     RLGEGRATSVSPLGLPRSVPNMVAGEIAIDTGACGPNFTVSSACASGTTAIGVARDLLL
                     GGACDVVLTGGAESARSRMSAASFAQMRALSTRTEHPEGACRPFDADRDGFVLGEGAAV
                     LVLEHPDHARTRGVTIRARLVGYGASADAHHPTSPHPQGAGSEQAIRQALADAGCTAAD
                     VGHVNAHGTATRAGDAAEALALLRVFDTAPPPVTANKSILGHALGAAGAIEAALTVLAL
                     ERQEILPTANLTRQDAGREMDIVTTRPRAAAIELALSTSCGFGGQNAALL"
     CDS_motif       7081..7128
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A6A29_RS22915_0001"
                     /evalue="3.30E-03"
                     /label="PKSI-KS_m3"
                     /locus_tag="A6A29_RS22915"
                     /protein_end="169"
                     /protein_start="153"
                     /score="10.2"
                     /tool="antismash"
                     /translation="GPNFTVSSACASGTTA"
     CDS_motif       7285..7323
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A6A29_RS22915_0002"
                     /evalue="1.00E-02"
                     /label="PKSI-KS_m4"
                     /locus_tag="A6A29_RS22915"
                     /protein_end="234"
                     /protein_start="221"
                     /score="9.4"
                     /tool="antismash"
                     /translation="FDADRDGFVLGEG"
     CDS_motif       7519..7563
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A6A29_RS22915_0003"
                     /evalue="9.70E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="A6A29_RS22915"
                     /protein_end="314"
                     /protein_start="299"
                     /score="8.9"
                     /tool="antismash"
                     /translation="VNAHGTATRAGDAAE"
     gene            complement(7985..9808)
                     /locus_tag="A6A29_RS22920"
                     /old_locus_tag="A6A29_38165"
     CDS             complement(7985..9808)
                     /GO_component="GO:0005777 - peroxisome [Evidence IEA]"
                     /GO_function="GO:0003997 - acyl-CoA oxidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006635 - fatty acid beta-oxidation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020684313.1"
                     /locus_tag="A6A29_RS22920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_38165"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="WP_241838615.1"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 7.9e-08, bitscore:
                     25.6, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSMLAGVVPVVDVSEVLRRAVFEGRGGWHEPWRRLLSGEAFRRPA
                     CPSAEEHLRWVYERLRLLGDVVGDPLELVRDPVRLACLHEWLSFVDPTLAAVTTIHYNL
                     FLGSLLGPDGTWMREVGDFTSVRRVGTFLLTEVAHGNDAAAVETTAVYDRGTDSFVLRT
                     PSAGAQKFMPNTSPVGGAKTGLVGARLIVDGADQGVFLFVVPLTDAAGVLPGVGVRRLP
                     ARLGSPLDHSLTWFDGVRVGREAMLAGPHGRISEQGEFRSDVPERRRRLLTSIGRVTSG
                     RICLSAGTVGTARAGLVLAVRYGRRRHITGLTESSRLPVFALRSHHGPLVEAIATVYAM
                     NMLYREAARRLGDHSGPGAVDAELFVSAAKAWITWRGREVGAQIRERCGAQGLLVSNGI
                     VQQLMAAEGAITAEGDNQAIMTQVAAELLLRHRPGHLVPGSPGRTLSDASWLHELLAAV
                     ERIWLDRAYEGRRKAPAQALARRNGAMGPALRAAELHAHRQAAEALFGAVAGLPAGAGR
                     ELLGRVHLLFTLRAVETHGGDLLRHGLITGEQVDEVPVLVERLVTELAQQADALVEAFA
                     VPEEFFAGMPVAAADYIGAYDDADRPWRRQA"
     gene            10001..11161
                     /locus_tag="A6A29_RS22925"
                     /old_locus_tag="A6A29_38170"
     CDS             10001..11161
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A6A29_RS22925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A6A29_38170"
                     /product="hypothetical protein"
                     /protein_id="WP_143197045.1"
                     /sec_met_domain="T2TS (E-value: 3.6e-18, bitscore: 58.2,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVHEREPSRQISEFLRLAAGRAAAYLSRSVGDGGVPSAELSLDP
                     GFGESFSSARARGVLRDRFGIDSGFDLAGEAFSAMVTLMLQPLPQDCAGKGLVAQLGSQ
                     IEAVRWRRRYRFFPHRNGFPADTDCTGMAVGALHRQGLLSAADLDGYVRDLLRAAAPTG
                     ITPAHRPGDDAALVPGVPLVYWEDDAEPGTGRRGRKHDAVACANALYTVQLCESRAAEA
                     AEFTDASHRYLADHLLSGRYLAGTRYYPSPDAFRYALSRLCARFPTSARVLSDPLHRAF
                     SEREATTSASTPPGDPDNVLDVALRTLTADNLSRSAGQAERRLLLAQTQRRDGSWPACP
                     YYRMGRFPVYFGSPYLTTVFALKALQTRENSSPDHQGRLPVHEVAP"
     misc_feature    10046..10048
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(11230..12234)
                     /locus_tag="A6A29_RS22930"
                     /old_locus_tag="A6A29_38175"
     CDS             complement(11230..12234)
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0046246 - terpene biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF040195.3"
                     /locus_tag="A6A29_RS22930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_38175"
                     /product="terpene synthase family protein"
                     /protein_id="WP_073722428.1"
                     /sec_met_domain="T1TS (E-value: 6.9e-64, bitscore: 209.7,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDGIRMPEVRLPFPAHEPNPHLARAQTSLDAWLDESAICRSAQSR
                     RSLERTRIPLVTALAYPDAAPDALELLVQWATWTFVIDDEFDDGPDGQDPARCARALAT
                     FLPVLDGAPVGGSASARAFAGTWERLVEGRSPAWCRMLRDDIRAYLWSYYEGLVDQLAE
                     RVPTLAAYRRQRCVSVAAYTWLDLVEIAVGVDLPETVRHFSSFRELREAAAGYVGLHND
                     LWSLERDKNAGAFHNAVLLVQHHDGSPLQEAVDEVNGLIAECAQRILDAERDLAVQLDA
                     AAITGQDGADALDCAAGYAKFVRGCFDYHYQARRYTAAATSHSREATAPHQLF"
     misc_feature    12414..12430
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     gene            13084..13284
                     /locus_tag="A6A29_RS22935"
                     /old_locus_tag="A6A29_38180"
     CDS             13084..13284
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A6A29_RS22935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A6A29_38180"
                     /product="hypothetical protein"
                     /protein_id="WP_073722429.1"
                     /transl_table=11
                     /translation="MCDRLRPSQCEGQLTPSRGAVAGRHCLLGATVGESWFWLSPTGFT
                     LLTALYAVKGLRLFRARRPAA"
     gene            13484..13825
                     /locus_tag="A6A29_RS22940"
     CDS             13484..13825
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007460020.1"
                     /locus_tag="A6A29_RS22940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_073722431.1"
                     /transl_table=11
                     /translation="MINGNVSLCLAAGRGRRVAQLGDAAAEWGRQVPEDPGITELADLF
                     EAAASAVPARPGGPGNVDRAFLAGVVEDLRAAARLGGLLPAVTVWHLHRAMEQERALRQ
                     HLHPGAPAG"
     misc_feature    13505..13507
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            14105..14653
                     /locus_tag="A6A29_RS22945"
                     /old_locus_tag="A6A29_38185"
     CDS             14105..14653
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020557425.1"
                     /locus_tag="A6A29_RS22945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_38185"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_073722433.1"
                     /transl_table=11
                     /translation="MNNEPFSVRKRVRFVELSAKALRALADGDLAAGSAEAGVALDEHF
                     VCDRARWIFGYRADQLAGDPSVAPWITRAAVSEPDGAVVGDAGFHGPPDEVGMVEVGFT
                     VVPGYRRQGYARAMLTALLVRAAAEPGVRTVRARIRSDNSASLATITGFGFTPVGEQGN
                     ERDGLTIVFEVPADVVQAE"
     gene            complement(15591..15785)
                     /locus_tag="A6A29_RS22955"
                     /old_locus_tag="A6A29_38190"
     CDS             complement(15591..15785)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A6A29_RS22955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A6A29_38190"
                     /product="serine hydrolase"
                     /protein_id="WP_073722437.1"
                     /transl_table=11
                     /translation="MEHPPPPDGTLLYHHSGATCGFHAFIGLNPQHRSALLALSNTKYR
                     RGSKILQPAYTALTTLHRH"
     misc_feature    complement(15943..15957)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 18.38"
                     /tool="antismash"
     gene            complement(15990..17093)
                     /locus_tag="A6A29_RS22960"
                     /old_locus_tag="A6A29_38195"
     CDS             complement(15990..17093)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010359818.1"
                     /locus_tag="A6A29_RS22960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_38195"
                     /product="sensor histidine kinase"
                     /protein_id="WP_073722439.1"
                     /transl_table=11
                     /translation="MRSLRVPAPLTDAALVCLAALDLWFNLDGGSPLEVAYGALACSAL
                     VVRRRYPPALFVLGLPATLFFSLTLIPFVTLYTLAGRARSRLLLTVCALASAAANATPW
                     PLAEYAEDGAARTFVDFVYLLATAAAPVFLGQLVQARGDVALRLAEVEESRDHERRLHA
                     EQVLARERAQLSREMHDVVSHQVSLIAVRAGALQVSARERQAQEAARTIRELSVSTLDE
                     LRHMVTLLRLSGGTVTELTPQPTLADLHRLVEGSGIEACLEGGLPAGLPATVQRTLYRT
                     VQEALTNVRKHAPGATAAILLWHDQDGLGVTVTNTSAPRPALPLPGSHHGLMGLRERAD
                     ILRGTLESGPTADGGYELRLRLPRQAE"
     gene            complement(17159..17842)
                     /locus_tag="A6A29_RS22965"
                     /old_locus_tag="A6A29_38200"
     CDS             complement(17159..17842)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020120363.1"
                     /locus_tag="A6A29_RS22965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_38200"
                     /product="response regulator transcription factor"
                     /protein_id="WP_073722477.1"
                     /transl_table=11
                     /translation="MVVDDEALIRSGFELILNAVGGIEVVATCGGGQAVDTMRRARPDV
                     VLLDIRMPDTDGLAVLREIRSMAEPPVVAMLTTFDSDEYVMKALRSGAAGFILKDTEPE
                     QLGQLVRTLAAGGVVLSPKASSAIVHAMPKESSTDEDMPRLLLLTDREREVLLLVAEGL
                     SNADIGARVHLSASTVKDHVSAILTKLQVAGRVQAALLAQRAGLLRAGSAWRRSVQGPL
                     PGPRR"
     gene            18060..19589
                     /locus_tag="A6A29_RS22970"
                     /old_locus_tag="A6A29_38205"
     CDS             18060..19589
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S41"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015531.4"
                     /locus_tag="A6A29_RS22970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_38205"
                     /product="S41 family peptidase"
                     /protein_id="WP_073722441.1"
                     /sec_met_domain="Peptidase_S41 (E-value: 4.8e-21, bitscore:
                     68.0, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNRNAHTAGTPRGAKWFAGSARRGLIVTAAALAVMLTACVMDGGG
                     GSAHPWPSDIDGTWQSAGYGTVYVIKQNKHSGVRELSVYENSGTSCVKGDAMTALGGER
                     DSGGAVSFGEDGDRELTVRRQGGHLLVQEFGSVGHIRMNRLTALPHCPSETPNDGPARR
                     LKTLDAFWQNLSEHYPPYAHRRLDLRDRERDHATLKGNNTDRTLEALLRRTVRKLGDMH
                     TGITWEGESSYGLRPGTRDSADLTDADIEAARSAIKVRLGAELRPVIEGKVEYATGLPG
                     GTGYLRITQLEELDGEESSYDDDLARFKRALDTVFTQGARDHWRGLILDLRLNDGGHDA
                     LGQELASRLTRHPHVAFKKRARDLSAPSGFTPYETVNVRPSRYPGFHGRLALLVSDLTV
                     SAGETTAMTLLNRSPAPTLIGRDTQGIFSDQLSRTLPGGPSLDLSNEDYRNSAGQSFEG
                     RGLPVDARFRTPVFTSAELEDGCDSALAMALDDLGHRKAGTTPRCPTKSGG"
     gene            19695..>19961
                     /locus_tag="A6A29_RS22975"
                     /old_locus_tag="A6A29_38210"
                     /pseudo=""
     CDS             19695..>19961
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020133567.1"
                     /locus_tag="A6A29_RS22975"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_38210"
                     /product="IS6 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLERVVRGGRSPSYKGHRCPVEVISHCVWLYFRFPLSFREVEELM
                     LERGVVVSHETVRRWCAKFGQCYASALRRRQPRPGDKWHPDEVL"
     gene            20147..20785
                     /locus_tag="A6A29_RS22980"
                     /old_locus_tag="A6A29_38215"
     CDS             20147..20785
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018523370.1"
                     /locus_tag="A6A29_RS22980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_38215"
                     /product="hypothetical protein"
                     /protein_id="WP_073722443.1"
                     /transl_table=11
                     /translation="MTHKGRIVFVVALTTLGLGLTACNGEDSATTQESPSASAPESSDP
                     SSKSPSAGTGDDAAAPAGDVAAPGTKVKIGDRAVLPFTYGTDKKGTIAVTVTAIEKGAE
                     ADMAAFGDKAKGMTPYYIRMKVENVGGTDLSYASLKLRGKLDGSGSTGVVLIGDLPGKC
                     DSESAPRDFTTKGASYETCSLSATKTDPIAAASFEEGDAYRDSPVLWTS"
     gene            21301..21471
                     /locus_tag="A6A29_RS45380"
     CDS             21301..21471
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A6A29_RS45380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_158074451.1"
                     /transl_table=11
                     /translation="MAARRLRLLLRHLTLRTLGNTALLQQHPHHQAHRPPCAPRCTEQM
                     PCVPRPRTGEE"
     misc_feature    complement(21962..21976)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.08"
                     /tool="antismash"
     misc_feature    22215..22230
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.29"
                     /tool="antismash"
ORIGIN
        1 gactcagcct tcacaccgat accggtgctc gctcccccgg gagggtctgg gcctcggttc
       61 cctcgggccg ctgacggcac agatcgagac cgccgccaga ggtcgttttc tcgtttcata
      121 ccctgccgaa agccgttgat tttatatcaa tggcagatat cagtcggctg gttgcctgct
      181 actgcttgag cctgggacct taatgagagg tgtatgcatt gcgcacggga gaagggccgc
      241 tcttttgtgg gagcggccct cgtgcgtagg ccgggccgtc ggcgggacat gccgggccta
      301 cgcacatcga gtgacctcga cgagaagact ttgcggcgcc tacagaacgg cgatggtgaa
      361 attgctgctc gcggggtggc cgtccttgag cgtgatgaca gtgatggcgt cccggcggct
      421 gtcgcacgcc cgggtgggct ctccgatggt tgagacgctg gtggtgccag gtccgccgtt
      481 ggcgaggatc agcgcgctgg agaggttgat gccggcgctc ggatcgacgg tgacgcagta
      541 caggccttcg gagacccggt ggctgtcggt tacgttcttc tgcctctcca gagcaccatt
      601 gaagtcgacc tctgcggccg ccctggcgtt cggggcgatg atctcgcccg gcgcggcgac
      661 ggcctggggg atgaacacag cagacagagc agcagttcct gcaagaacag cagcgaatcg
      721 acgcatgagc tcactcctgg aattgtttca tagcgctggt gcgctctacg gagttgatta
      781 ttcgccagtg aactgagcgg cacgttggta gcgggaatcg ttcacatatt cgcgaggtca
      841 ctcgattgat cttgtgcctg tcggggcgcc gactgtcggc gtcaggttgt ttcccgccgc
      901 tgaccgggac ggtgattccg accgcagctg caccccggcc cggcctcgcc gggccggggt
      961 gcgcgcggag atggtaatgg aaccaccgga ccgttcggcc ggcgccccag catggccagc
     1021 tcagtctgga tgtacggcgt tgtcagcaac atgtcctcca cctccaggat cgacttcaac
     1081 accgacctct ccgatgtggg gaccgtggcc accatcttca ccgacagcaa ctacggcggc
     1141 gactggcagc acctgcggcc aggcagctac aaccgcctcg ccgacgctgt tgtcgtcggc
     1201 gctgtcgccg tcgacgacaa caccctcagc tctctgcgcg tagccgccgg attccggttc
     1261 actcggtatc aggacccgag cttcgccggc cagcagtgga cctttaccgc ggacacccct
     1321 tatgtcggcg acgacgccaa cgatcaggca tcctccatcg tcgtcacgcg gatctgagcg
     1381 gctttggtac ggttcgttgc tgatccttgg tggcgggtct gttggagggg gagtgcctgg
     1441 tccacggcgg tgacgatggc ttcgaggctg gtgtgggctc ggcggggtgg tcctcgtact
     1501 tcgccgagcg ccagatgcgt tcgatgtcgt tgagttcggg gctgcggggc gggaggcaga
     1561 acagcttcac tccggtcttc gcgagctggt cgcggcggtc cttgagcgct ttggccacgt
     1621 gtgcggaggc gttgtccagc accacggtgc agggccggga ccggcgccga acgggcaggc
     1681 gagcaccgac accgtcaagg acaaggcgtc ggccccagcc gtgcgtgtcc attcccggct
     1741 ccctgagcga catcggagcg gggatcgacg gcactgcgtg gggcgtcaac gccggcggca
     1801 gcatctaccg ctataccggg gaccagcccg gctgacacat gtctcccccg caccgggcca
     1861 ccgacgacgt ccatatcccc cagcacgaca ccctcgtctt cggcaatcgc cggggcgccc
     1921 gggtcgagct cgttcccggc acgcgcccga agcggtcacc gagtttgccg ccgaggatca
     1981 ggcaggcgag cggtcatacc gagttacccc ggacctgcca ccactgggct gcggacccgc
     2041 agtctcagga ccatcccggc accgcgtgcg tcagcgcgac gacctggcgg gccccgtcgc
     2101 ggggcggccc gccacggcat cctgaccgcc acgcgcatcc gctgacgagc accggctgtg
     2161 tgtggcggct gctggccatc gggtgatgct cctgaggtcg ggcgcttcgt ctggcgggtg
     2221 cgcgttgcgg ctggccagca tggacgcgcg ccaggcccgg catgcctggc ggtgccggtg
     2281 ttccgagagc gcattgcgga tgcccgtggc gctccgtcgg cggcgaggct gggcggtcgg
     2341 ttcgccccgg cgtgcgccgg tgagtgagct gcttcacgac cgagcttcca gagccccctc
     2401 gcggggcggt ttcccatgga aagtccgtga tgaggttgaa cacgccaata gcgtcgttcg
     2461 ggtcgcggtc cagggaggcc gtggcgttga cgtgaaggga aactgcatgt tcagcagcgg
     2521 aatgacccgt gtcatggcat ggaccggcgc ggggatcggt gtggtggcaa ccgtgctggc
     2581 gggggtggcc atcgcggctc cggccgccaa cagctcccag gctccgtacg tacaggccgg
     2641 cgcgctggtc aacgcggacg cctcgatcgt gcactccaag ggcgtcaagt cggtgaccgc
     2701 ctcgggccac gtcttctgcg tcgagatcgg caacgaggac gtcgacctgt ccagggccat
     2761 catcactgcc accccccgcg acaccgcggg ctccaccctc cgggtcatcc cgtccaactg
     2821 cgcgggcgga aagggcatca ccgtcgccac ctacaatccc tccggcggcg gaatggccaa
     2881 cgggttctac atcgcggtcc tttgacctga tctccgcacc agaacccgtg cggccccgtt
     2941 gcacggcaac ggggccgcac gatgcgcgac gagaagcgga tccggttcag gcggcgtcag
     3001 tcacggggtt gtgctggtct tctcgtcgtg ctggcggagc atgcgcatga cggtggccgg
     3061 tgaggggcgg cggtccttct tcttgccggt ggtgatgacg agtcgggcgg ccatgtcgcg
     3121 caggctcatg tcctggccgc gcgggtggag ggccatggac cgcacgtggt cgtcggcgac
     3181 ggctgttccg ccggtggtcc tgccgcgttt gcgagcggat tcgtggcttt cgagggtgcg
     3241 gtcgcggatg tactcgcgtt tcatcccgga cagggccgcg agcacggtga acacgatccc
     3301 tccggggccg tgggagccct ggcgttcgcc ggtcaggaac tccaggccga cgtcgctcgc
     3361 cttgaggtcc ccggccaggg ccgccgggtc gatgccgcgg ccgagccgtt tgtgttcgtg
     3421 gaccacgagg gtgacgccga ccccggaggc gcgcgcctcg cgggcagggc cgaccgcctt
     3481 gcccggctcg ggccgctggt ggcgcgggtg gagatcttct cggcgagcac ccgggtcaca
     3541 cccgcttcag cgagggagcc gagtgggcag tccagcgatc ggcgggcgtt ggacgcccgg
     3601 gcgtacccca ggcatacgtg ccccacgggt tcggcgccgg cgggccgggg cgggtcggtc
     3661 cacgcggagc ccgggccggc gcacggcagg tgttgccacc gcgagggcct tggcgagttg
     3721 gggcaccagg cggagccggg cggtgtgctc ctggatcgcg accctggcct tggaggttcg
     3781 gcacggcgag tctgccgggg ccgcgcagga ggacatcggg cagtcgcacg cttccacgcg
     3841 cgtgaagtcg tcgctcacac cctgaccgtt tcatgggtac gtttcaattg cgctacgtcg
     3901 gcaccgcccc tccggagtgc gccgcgaagc tcccgcgatg ggtgagacgg gaggggctgc
     3961 gtgacctgtg gccagttcgt atttcgggcg ggtaggtgga ggcgctgggg ccgtcggcgc
     4021 atggtcatgc ggtagagcgt cacttctcct cgccggaaga ggatctcgca ggttttgaga
     4081 tagagacggt agcgctgata ggtttccggg cccaccgctt tctcggcttg ttcccgtgcg
     4141 gcgaggagcc gcgtggacca ggcacgcagg gtgcggacgt agtcctgggg ggcgctggtg
     4201 agggcggtaa gggagaagaa ggcgtcgcat gccgccgcga tctctgtcag gcgtggcagg
     4261 gccgaggcgg ggaagacgtc gccggcgaag aacgcgccga ccgggccgtc ggcgtcgatg
     4321 ccgccgtcga aggcgatggt ctgcagcgac agcgtgccgc cgggggcgag ccagctgtgg
     4381 cacgcggcga agaagccgct gtaagcctct acgcgctgcc ctggggtgag gccggggccg
     4441 gcgaaggctt cgaaggcttc gaccgagacg atggcgtcat agacggagtc aggggtgtga
     4501 aaccgccagt cctcaaggcg tgcctgaacc tgcggcaggg caagggagtt gacgtgggcg
     4561 agctgggcgc ggctgagcgt cagcccggtc atctcgccag cgtggtcctc ttccgcggcg
     4621 agggcgagca ggccgcccca tccgcatccg atgtccagca gccggccgcc ccgggggagt
     4681 gccgcctggt ccaggtgacg ccgcagtttg tttcgttgag ctcgggccag ggccgcgacg
     4741 tcaccgggat cggtatcact ggtgatgccg tcccaggcgg cggctgagta ggtcaaggtg
     4801 tcgtcgagcc acagtgagta gaagtcgttg ccgacgtcgt agtggaactc gatgtcctcg
     4861 gcgctcgcgc ccgtcgtcgt agtcacgctt tccctgttcc tggtggtggg tgagaggtct
     4921 ccggccgcga gggctccgca cggcgggccg ggggacgggg cgcgtgctgg gcttcgccca
     4981 gggcgtgacg gccgacgccc ggaccctccg gggcccctgg aacctcgtaa ccgtgtcagc
     5041 gggccgggca ggtgatcaaa tcgcctatca cccacacgga gcagcgcgtg acctcgcccc
     5101 ggccccgggc cctcggctgc ccggccacgg acggggcggg ggtggagacg gggcacggca
     5161 gtgactttcc tggccgggcg gggttgtcag gccacagccg ctttcgaagg tcagagaaga
     5221 gccatggcag acatcacagt gcaggacttc gacgaggcca cactggccga tctggtgcac
     5281 gagtacttcc aggtgccgcg cgaccagctc catgcggtcg cgacactcga cgaactgggc
     5341 ttggactccc tggccctgat ggaactgatg gtggtcctcg aagagcgaag cggaatggag
     5401 ctcctggatc ggctgaagga cctgtcgttg gtgagcacgc tgcgcgacgc ggcacaggtg
     5461 atcaaggaag cggtcgatgc gtccgcccgc aaagccgtgg tctcccaccc ggcagggcta
     5521 cccaacccag ccgcgtgacg gcgagaacac ccgccccccg gcttcccctc acgcgcccga
     5581 ccaggaacgg caccccacca cagccatgac caaccacccc atcccaccac cccccgtacg
     5641 cggccacctc gacctgctgc gcgaactcga accggccgtc gcccatcacc tcgaccgcca
     5701 tctcaaggca gcatcggagt ggtttcccca ccagtacgtc ccctggagct cggcccacga
     5761 cttcgagggc cccctgggcg gcgaaccctg gaacagcggc cagtcgcacc tgcctcccgc
     5821 cgtacgggac gcgctgctcg tcaacctcct caccgaggac aatctgccca gctaccacca
     5881 cgagatcgcc accagcttcg gacgtgacag cgcctgggga acctgggtgc accgctggac
     5941 cgccgaggaa ggccgccacg cagaagccct gcgcggctac ctgcacgccg tgcgcggcct
     6001 ggacccggtg gaactggagc gcgcccgcat ggcacatgtc ggcgccggct accagagtcc
     6061 ccacccgtcc ctggcccacg gcctcgccta cgtcaccgtg caggagctgg ccacccgcga
     6121 ggcgcaccgc aacaccggcc acgcctgcga cgaaccccac ggcagacggc tgatgacccg
     6181 catcgccgcg gacgagaacc tccacatggt cttctaccgg gccttgtgtg ccgacctcct
     6241 cgacctggcc cccgaagaat tcacaaccgc gttcgccgac gtggtctgcg acttcacgat
     6301 gcccggccac ggcatccccg gcttccaggg acgggccgcg cgcattgccg cggccggcat
     6361 ctacgacctc agcgttcacc accaccatgt gctcctgccg ctgctgcgca ccctgggcgt
     6421 catggagcga accggcctgc gccccgaggg ggaggaggca ctggaccgta tcggacggca
     6481 cctggaagac ctgaccgaca aaggaaaacg gctcgcaaac ctccaagacc ggatgcgaca
     6541 gcgcacacaa cagaccgccc gatcaacagg actggaagcg cgcccccgcc cggccagtga
     6601 caaagaactg gaagtgcccc gatgacaggt cgcggcgatg tcgtggtcac cggcctaggc
     6661 ctgatcaccc cagccggcca tgacgccgac accctctgga aaactatgtc cgccggacag
     6721 tcgctggccc ggagagaccc cgacctggca ggcctgcccg tcgacatcgc ctgcgccgtc
     6781 ccggatctcg acccggtcgc cgaactcggt atccgcctcg ccggccggct cgaccgcttc
     6841 gcacacctgg gcctgattgc cgcacgccgc gccctgcacg acgcccacct cgacccccga
     6901 accggacgcc ccccacgcgt aggcgtcgtc ctgggagtgg gggcgaacag cctgcagacc
     6961 tacgtcaagg agttcacccg cctcggcgaa ggccgggcca ccagcgtctc ccccctgggt
     7021 ctgccacgca gtgtgcccaa catggtcgcc ggggagatcg ccatcgacac cggggcttgc
     7081 ggcccgaact tcaccgtctc cagcgcctgc gcatccggca ccaccgccat cggcgtcgcc
     7141 cgcgacctcc tcctgggcgg cgcctgcgac gtcgtcctga ccggcggcgc cgaatcagcc
     7201 cgctcacgca tgtccgccgc cagcttcgcg cagatgcggg ccctgtccac ccgcaccgaa
     7261 caccccgaag gcgcctgccg gcccttcgac gccgaccgcg acggcttcgt gctcggcgag
     7321 ggtgcagccg tcctcgtcct cgaacacccc gaccacgcgc gaacccgcgg cgtgacgatc
     7381 cgcgcccggc tggtcggcta cggagcctcg gctgacgccc accaccccac ctcaccccac
     7441 ccccaaggag cgggaagcga gcaagccatc cggcaggccc tggccgacgc cggctgcacg
     7501 gccgccgatg tcggacacgt caatgcccac ggcaccgcca cccgggccgg cgatgccgcc
     7561 gaggccctgg ccctgctccg cgtcttcgac acagccccgc ccccggtgac ggcgaacaag
     7621 agcatcctgg gccacgccct gggggccgcc ggcgcgattg aggcggcact gaccgtcctg
     7681 gccctggaac gccaggagat cctcccgacg gccaacctca cccgccagga cgccggacgg
     7741 gaaatggaca tcgtcacgac ccgcccccgg gcagctgcca tagagctggc cctgtccaca
     7801 tcctgcggat tcggaggaca gaacgcggcc ctcctgttcg ccatcccctg agtcaggcac
     7861 tcccgcccaa tcggcacgtc ccttcaagca acgggaagcc ggtggcgccg cgcccgctcg
     7921 gggagaggcg gaaggggaca gcgcccgggc aaaccgcccc gaggacgggc ggcctcccgg
     7981 acactcacgc ctgccggcgc cacgggcggt ccgcatcgtc gtaggccccg atgtagtcgg
     8041 ctgccgccac cggcatgccc gcaaagaact cctccggcac ggcgaacgcc tccaccagcg
     8101 cgtcggcctg ctgtgccagt tcggtcacca gccgctccac cagcaccggc acctcatcga
     8161 cctgctcacc ggtaatcagc ccgtgacgca gcaggtcacc cccgtgagtt tcgacggcgc
     8221 gcaaggtgaa cagcagatgc acccgaccca gcagctcccg ccccgcaccg gcgggaagcc
     8281 cggccacagc accgaagagc gcttcggccg cctgccggtg cgcatgcagc tccgcagcac
     8341 gcagcgccgg ccccatcgcc ccgttgcgcc gggccagggc ctgcgccggg gccttgcgcc
     8401 tgccctcata cgcccggtcc agccagatgc gctccaccgc ggccagcaac tcgtgcagcc
     8461 agctggcgtc gctcagcgtg cgaccgggcg aacccggcac caggtgcccg ggacggtggc
     8521 gtagcaggag ttccgccgcg acctgagtca tgatcgcctg attgtcaccc tcggcggtga
     8581 tcgcgccctc ggcggccatg agctgctgga cgatgccgtt gctgaccaga aggccctggg
     8641 cgccgcagcg ttcacggatc tgggcgccca cctcgcgccc ccgccacgtg atccacgcct
     8701 tggccgccga cacgaacagc tcagcgtcca ctgcgccggg cccgctgtga tcccccagac
     8761 gccgggcggc ctcgcggtaa agcatgttca tcgcgtacac cgtcgcgatc gcctcgacca
     8821 gaggcccatg atggctgcgc aacgcgaaca ccggcagccg tgaggactcc gtcagcccgg
     8881 tgatgtgccg cctacggccg tagcggacag ccaacaccag cccggctcgc gcggtcccca
     8941 ccgtgccggc gctcagacag atccgcccac tcgtgacccg tccgatcgac gtcagcaggc
     9001 gacgacgccg ctcgggcaca tcgctgcgaa actcaccctg ctcactgatc ctgccgtgcg
     9061 ggccggccag catcgcctcc cgccccaccc gcaccccgtc aaaccaggtc aggctgtgat
     9121 cgagcggact tcccagccgt gcgggcagcc gccgcacccc aacaccggga aggacaccgg
     9181 ccgcgtcggt gaggggcacc acaaagagaa agaccccctg gtcggcgccg tccacgatca
     9241 gacgcgcacc caccagaccc gtcttcgccc cgccgaccgg gctggtattg ggcatgaact
     9301 tctgcgcccc cgcgctcggg gtacgcagaa cgaaactgtc cgtcccgcgg tcgtagaccg
     9361 cggtcgtctc cactgcggcc gcatcgttgc cgtgcgccac ctccgtcagc aggaacgtgc
     9421 ccacccgccg caccgaggtg aagtcgccca cctcccgcat ccaggtcccg tccggcccca
     9481 ggaggctgcc caggaacagg ttgtaatgaa tggtggtcac cgctgccagc gtcggatcga
     9541 cgaacgacag ccactcatgc agacaggcca gccgcaccgg atcccgcacc agttccagcg
     9601 ggtcgccgac aacatcaccc agcagccgca gccgctcata cacccaccgc agatgctcct
     9661 cggccgatgg gcacgcagga cgccggaacg cctcaccgga caacaaccgc cgccacggct
     9721 catgccagcc ccctcggccc tcgaacaccg cacgccgaag aacctccgac acatccacca
     9781 ccgggaccac acctgccaac atgctcatgc ccgcccaacg aagcccacct tcacatggac
     9841 acgcacagcc cccgccaccc gaaccgggcc cggcacgtcc acagtgcacg aaggacacgc
     9901 acggtgaacc gagcggttga accttgggct acctgggcac ggcacgatga cgaagcaggc
     9961 gatcagacgc aggcattggg agaaccgggg gagtcgtgac gtgtccgtgc acgagaggga
    10021 gccatcacgg cagatatcgg agttcttacg gctcgctgcc gggcgcgccg ccgcctacct
    10081 gagccggtcc gtcggggacg gtggggtgcc gtcggcagaa ctgtcactcg atccagggtt
    10141 cggggagagc ttctccagtg cccgtgcgcg tggagtgctg cgggatcgtt tcggcatcga
    10201 ctccggcttc gacctggccg gtgaggcgtt ctcggccatg gtgactctca tgctccagcc
    10261 gctgccccaa gactgtgcgg gcaaggggct ggtggcccag ttgggctccc agattgaggc
    10321 ggtccgatgg cgccggcgat accgtttctt cccccaccgc aacggcttcc cggcagacac
    10381 cgactgcaca ggcatggcgg ttggcgcctt gcacaggcag gggctgctct ctgccgcaga
    10441 cctcgatgga tacgtacgtg accttctccg ggccgccgcc ccgaccggca taacccccgc
    10501 ccaccgcccc ggcgacgacg cggccctcgt cccgggggtt cccctcgtct actgggagga
    10561 cgacgccgaa cccggcaccg ggcgccgcgg gcgcaaacac gatgcggtgg cctgcgcgaa
    10621 cgccctctac actgtccagc tctgcgaaag ccgggccgcg gaggccgcgg agttcaccga
    10681 cgcctcgcac cggtacctcg ccgaccatct gctctccggc cgctacctgg ccggcacccg
    10741 ctactacccc tccccggacg cattccgcta cgccctctcc cggctctgcg cacgattccc
    10801 cacaagtgca cgagtgctgt ccgaccccct gcaccgggca ttcagcgaac gtgaggcgac
    10861 cacctccgcc agcacaccac ccggtgatcc ggacaacgtc ctggacgtgg ccctcaggac
    10921 gctgaccgcc gacaacctct cccgctcggc cggccaggcc gaacgaaggc tgctgctcgc
    10981 gcagacacag cgacgagacg gttcgtggcc cgcctgcccc tactaccgga tgggccgctt
    11041 ccccgtctac ttcgggtccc cctacctcac caccgtcttc gcgctgaaag ccctccagac
    11101 gcgcgagaac tccagccccg accatcaggg ccgcctgccc gtccatgaag tcgccccctg
    11161 aagcagccca gcctccgtgt gaggggttca aagccgggtc gggttccaag cccgggacag
    11221 ggagggcggc tagaagagct ggtggggcgc ggtggcttcg cgggagtgac tcgttgcagc
    11281 ggcggtgtac cggcgggcct ggtagtggta atcgaagcag ccacggacga acttcgcata
    11341 gccggcggcg cagtccagcg cgtccgcgcc gtcttggccg gtgatcgcgg ccgcgtcgag
    11401 ttggacggcg agatcgcgct cggcgtcgag tatgcgctgg gcgcattcgg cgatcaggcc
    11461 gttgacctcg tccacggctt cctggagcgg tgagccgtcg tggtgctgga ccaggaggac
    11521 cgcgttgtgg aaggcccccg cattcttgtc ccgttccagg gaccacaggt cgttgtggag
    11581 ccccacgtac ccggccgcgg cttcccgcag ttcgcgaaaa ctggagaagt gccgcaccgt
    11641 ctccgggaga tcgacgccca ccgcgatttc gaccaggtcg agccatgtgt acgcggcgac
    11701 ggagacgcaa cgttgccgcc gatacgccgc cagcgtcggg acccgctcgg ccagctggtc
    11761 gacgagcccc tcgtagtacg accacaggta ggccctgatg tcgtcgcgga gcatacggca
    11821 ccaggccggt gacctgccct ccacaaggcg ctcccacgtg ccggcgaacg cccgcgccga
    11881 tgccgagccg ccgactgggg ctccgtcgag gaccgggagg aacgtggcga gggcgcgcgc
    11941 gcagcgggcg gggtcctggc cgtcggggcc gtcgtcgaac tcgtcgtcga tgacgaaagt
    12001 ccacgtcgcc cactgcacga gcagctccag tgcatccggc gcggcgtctg ggtaggccag
    12061 cgcggtgacc agcgggatcc gggtgcgctc aagggagcgc cgcgactgcg cggagcggca
    12121 gatggcggac tcgtcgagcc acgcatcgag cgaggtctgc gctcgtgcga gatggggatt
    12181 cggctcgtgc gcgggaaaag gaagacggac ctccggcatg cggatgccgt ccatccggga
    12241 agggaacggc ccgtcagccg ctccgctgag caaagccgtg tccacagctg tctcgtccct
    12301 caccgatcat cccctcccaa ggcccctcgg ccagcgtacg gtggccagat tgcccgcgac
    12361 ccgcgatctg gacggccgcc agcgacttcc ccggacgacc ggaccacttc cccgggtaac
    12421 tttcgaacag cacatgggcc tggatgccgg gcagggtccc gccggccacg gtgtcggcga
    12481 gggcagcgag gccctggtag tggcggatgg ggctggggcg gcgggctgct gcgggtccgt
    12541 ctcacccggg gcggccgccg tacgccggga gcgccggcgg atgacgtcgg gcaggctgcc
    12601 cggtctgacg gcgtgctcac ggaatctgtc aacttccgta gagccgaagg ccgcggcagt
    12661 accactggag cgctaagacg cgcgggggcc cgagctgccc ggctccgccg gctgaggaag
    12721 gggtgactgg gaggattcct ggggggcctc cccgaagcag acacaaacag tgtggtccgg
    12781 gcccaggcag gtgccgctct ccgcgccttt cagctggcac gcgaaattgc atgcaccctc
    12841 gtcggggcac agggttccgg gagcgcagcg cggagcgttc gattgcgggg acgccgaggc
    12901 tccggtggct ccgccgaggg ccaggacgat cgtgagagcg gcgacggcta tgcggactcg
    12961 catgggcttt cctcctgatg ggggttgaat tcgtaggcca atctcagcgg gttcggggtg
    13021 cgggtgcgcg cgggactgct ccgtccgtgg cccacgggct tcggcgtagt cccgtgatac
    13081 ctggtgtgtg atcgtctgag gccgagccag tgcgaggggc agctgacgcc cagccggggc
    13141 gccgtcgccg gcaggcactg ccttctcggg gcgacggtcg gggaatcctg gttctggctc
    13201 tcccccaccg gcttcacgct cctgaccgcc ctctacgcgg tgaagggcct gcgcctgttc
    13261 cgcgcccgcc gccccgcagc ctgacccgca cgaagcgccc cagctggaca ctcatgccgt
    13321 cgcccactcc acttcacccc gagtgcggcc agctgctctg ctgctccggg ctcagcccag
    13381 cgggcctttg agcccgggat ggcccggcat gcgaccggga ttgggctgtt gcttgccgac
    13441 agttttgtgt tctcgtgttc gggtggtggg ggacgatgtc tctgtgatca acgggaatgt
    13501 ctctttatgt ctggcggcgg ggcgtggccg tcgtgttgct cagctcggtg acgcggcggc
    13561 ggagtggggc agacaggtgc cggaggatcc gggtattacc gagctggccg atctcttcga
    13621 agcggctgcc tctgctgttc ctgctcggcc cggcgggcca gggaacgtcg acagggcctt
    13681 tctggccggt gtggtggagg atttgagggc ggctgcccgg ctcggcggcc tgcttcccgc
    13741 agtaaccgtg tggcacttgc accgcgccat ggaacaggaa cgcgccttgc gccaacacct
    13801 gcaccccggg gcgccggcgg gatgagtgga gggtgcgccg cccgcctcga ttccctcgat
    13861 gccgcccggc gcctcgacgc tctgaaccgc cggccgtgag cgtccaacac agcaagagac
    13921 cccggacgct acgtcccggg gtcccgcggt gcactgtgac gtgtccggca aggttcaacg
    13981 accggccacg gcccggtgtc acgcccattc cgccccgagc tctccgcgag cacgtcgagc
    14041 ggccatgtcc gccggggccg taaagcggtg gacagttttc cggtgctggg cgagcatctc
    14101 cgcgatgaac aacgaaccat tctccgtccg taaacgtgtc cgcttcgtcg agctcagcgc
    14161 gaaggcgctg cgggcgcttg ccgacggcga tcttgccgcc ggcagcgccg aggccggggt
    14221 cgcccttgac gagcacttcg tctgcgaccg ggcccgctgg attttcggat atcgcgcgga
    14281 ccagctcgcc ggggacccgt ctgtcgcgcc ctggatcacg cgggccgcgg tgtccgagcc
    14341 ggacggggcc gtcgtcggtg acgctgggtt ccatgggccg ccggacgagg tcggcatggt
    14401 cgaggtgggc ttcaccgtcg tgcccgggta tcgccgccag ggctatgccc gcgccatgct
    14461 gacggcgctg ctcgtcaggg ccgccgccga acccggtgtc aggaccgtgc gggcccgtat
    14521 caggtccgac aacagcgcct ccctggccac catcacgggc ttcggtttca cacccgtcgg
    14581 cgagcagggg aacgagcgcg acgggctcac gatcgtcttc gaggtcccag cagacgttgt
    14641 tcaggccgag tagcgctgcg gcccaggcgg ccatggtgag cgtccgaatg ggccgtgaca
    14701 tgagacgggc cgcacgggtt gggcgagttg tgaagccgac ctgggcccga gcggcctgtt
    14761 cccatcctgc cctgaccggc gtctcacgca cacatatcga cgagtagcta ccagagcctg
    14821 ccaatgtgtg ggaagccgcg cggcagtccg cgctccgcga ggcccggggc gggagcaccg
    14881 gctggcggag ggtgtcggcc gaaagcccaa gccggtcttc ctctgattcc gtgaggcagc
    14941 tcgccggtgc cggcagggct atcaggtgac cggtcggagc accgacacgc ccaccgccgg
    15001 gcccgccgcg cgggccggcc ggtgtgggtg cgtcgtgggt ctcgcttcgg cccttccccg
    15061 tccgaccgcg ggccgggaag cgtgccccgc tccggttctg cgagccagta gcgcgtgagg
    15121 tgccgatgcg gatcactgta ggcggaccgt ccgtggacga gacgctgatt gtcccagagc
    15181 aggatcgcac cctcggcaaa caggatggag gtcttgttca gacgaaagaa ctccacgatc
    15241 tgatcggcca gttcggcctc ttacacgccc agtgcccccg atcgggaact ctcctcgtcg
    15301 accaccgggg catacgaccc cgtcctgagc aagttgtagc tcatgcggat gatcgagcgc
    15361 ccggccgtgg agtcgacgac gggacgacgg atactggaac cgccgagctc ctcgtggtcg
    15421 taggaaagcc actcgcgcgc acatcgtgca gcgagagacc tcgtccagag acgcggtgaa
    15481 ggtgcgcaga ccggccagtt ccgtatgccc accgccgcac gccgcctgga cacgacaatg
    15541 aagcaccacc tgtcgaggag gcacccgaca ccctgcaccg tcctgtcagg tcagtgtcga
    15601 tggagtgttg tgagggcggt gtaggcgggc tggaggattt tgctgccgcg gcggtacttg
    15661 gtgttggaca gggcgagcag ggcgctgcgg tgctgggggt tgaggccgat gaaggcgtgg
    15721 aagccgcaag tggcgccgga gtggtggtac aggagagtgc cgtcgggcgg gggcggatgt
    15781 tccatatgag tgccaggccg cggccgcccc ggtgagggag ctgcagccgg ggctgaagga
    15841 cgtcaccaag gagggaagcc gaacagcagc gcgggacgac cgtcaccccc gcgatcagtg
    15901 gaatgttcca atgcggctac ttgcgttcgg tcaattcgcg ccaatttacc gaaaaggcac
    15961 tctgttgccg ccgttctcgg tcgcggtgcc tattccgcct ggcgcggcag ccgcagacgt
    16021 agctcgtagc cgccgtcggc ggtggggccc gattcgagcg tgccgcgcag gatatcggct
    16081 cgctcgcgca gacccatgag tccgtggtgc gagccgggca gagggagcgc tggccggggc
    16141 gcggaggtat tggtcacggt gacgccgagg ccgtcctggt cgtgccacag caggatggcc
    16201 gccgtggcgc caggggcatg tttgcggacg ttggtgaggg cttcctggac ggttcggtag
    16261 agggtgcgct gaaccgtggc ggggaggccg gcgggaaggc cgccctccag acaggcctcg
    16321 atgccgctgc cttcgaccag ccggtgcagg tcggccaggg tgggctgcgg ggtgagctcg
    16381 gtgacggtgc cgccggagag ccgcagcaga gtcaccatgt gccgcagttc gtccaaggtg
    16441 ctgacgctca gctcccggat cgttcgcgcg gcctcctgcg cttgcctctc cctggcggac
    16501 acttgcagtg cacccgcccg tacggcgatg agacttacct ggtgggagac cacatcgtgc
    16561 atctcgcggg agagctgagc ccgctcgcgc gcgagcacct gctcggcgtg caggcggcgc
    16621 tcgtggtctc gggactcctc gacttcggcc agacgcaggg cgacgtctcc gcgggcctgg
    16681 acgagctggc ccaggaagac gggggcggcg gccgtggcaa gcagatagac gaagtcgacg
    16741 aacgtccggg ccgcgccgtc ctctgcgtat tcggccagcg gccagggcgt ggcgttggcc
    16801 gcggcggagg ccagagcgca gacggtcagc aggagccggc tacgcgctcg cccggccagc
    16861 gtgtagaggg tgacgaaggg aatcagcgtg agtgagaaga acagggtggc gggcaggccc
    16921 agcacgaaca gagccggtgg gtagcgccgt cgaacgacga gggcggagca cgcgagcgca
    16981 ccgtatgcca cctccagggg gctgccgcca tccaagttga accacagatc aagggctgcg
    17041 agacagacga gcgcggcgtc ggtcaacggc gcgggtacgc gaagcgaacg catcgctcgc
    17101 actcgggcag gccgtctgcc cttgggcagg agaacccgtg cagctcctgc cgtccgtctc
    17161 accggcgagg tccgggcaga ggcccttgca cggacctccg ccaggccgac ccggcacgca
    17221 gaagtccggc ccgctgagca agcagcgccg cctggacccg tccagccact tgcagcttgg
    17281 tcaggatcgc gctgacatgg tccttgaccg tgctcgcgct gaggtggacg cgggcaccga
    17341 tgtcggcgtt cgacaggcct tcggcgacca gaaggagcac ttcgcgttcg cggtcggtca
    17401 gcagaagcag gcgcggcatg tcttcgtcgg tgctgctctc cttgggcatt gcatggacga
    17461 tggcgctgga tgctttgggg gaaagtacga cgccgcccgc tgcgagcgtg cggaccagct
    17521 ggccgagctg ctcgggttcg gtgtccttga ggatgaagcc ggctgccccg gagcgcagcg
    17581 ctttcatgac gtactcgtcg gaatcgaacg tggtcagcat ggcgactact ggcggttcgg
    17641 ccatggagcg gatctcccgc agaacggcga gtccatcggt atcgggcatg cggatgtcga
    17701 gcaggacgac atctggcctc gcccggcgca tcgtgtccac cgcctggcca ccaccgcagg
    17761 tggcgacgac ctcgatgccg cctaccgcat tcaggatgag ctcgaacccg gaccggatca
    17821 gggcttcgtc gtccaccacc agtacccgga tcacctgtac ctcctctcgc tgccgctgcc
    17881 gctgccgctg ccgctgccgc tgcggatcgg cgcggacaag gacagagacg gaacccatcg
    17941 ccgcacctgc cgcgcgtgcg cccgaccgcc acccggcggg tcgaggccca ccgaccggcg
    18001 gggtcgcccc cagcttccgg cggatggcga tcgccccgcg cagccagcag cttagacgga
    18061 tgaacaggaa cgcacatacg gccggtaccc ccaggggcgc caaatggttc gcgggcagcg
    18121 cccgcagggg actcatcgtg actgctgccg cactggccgt catgcttacg gcctgcgtca
    18181 tggacggcgg cggtggctcc gcccacccat ggccgagcga catcgacggc acgtggcaga
    18241 gcgccggata cggcaccgtc tacgtgatca agcagaacaa gcacagcggt gtgcgggagc
    18301 tttccgtcta cgagaattcc ggcacgagct gtgtcaaggg cgatgccatg acggcactcg
    18361 gcggcgagcg tgacagcgga ggcgcggtgt ccttcggcga ggacggtgac cgcgaactga
    18421 ccgtccgcag gcagggtggc cacctgctcg ttcaggaatt cggctcggtc ggtcacatca
    18481 ggatgaaccg cctgacggcg ctcccgcact gcccgtccga gacaccgaac gacggccccg
    18541 cccgtcgtct gaagaccttg gacgcgttct ggcagaacct gtcggagcac taccctcctt
    18601 acgcgcaccg acgcctcgat ctgcgtgacc gggaacgtga ccacgcgacc ctgaaaggca
    18661 acaacaccga ccgcacgctg gaagctctgc tgcgacgtac cgtccgcaag ctgggtgaca
    18721 tgcacacagg catcacctgg gagggcgaga gcagctacgg actgcggcca ggcacccgcg
    18781 attcggccga tctgaccgac gccgatatcg aagccgcacg gtccgccatc aaagtccggc
    18841 tgggagccga actgcggccg gtcatcgagg gaaaggtgga gtacgcgacc ggcttgccgg
    18901 gcggaacagg ctacctgcgg atcactcaac tcgaggagct cgacggcgag gaaagcagct
    18961 acgacgacga cctcgcgcgg ttcaaacgtg ccctggatac agtattcacc cagggcgcga
    19021 gggatcactg gcgcggcctg attctcgatc tgaggctcaa cgacggcgga cacgacgcac
    19081 tcgggcagga acttgcatcc cgtctgacca ggcatccaca tgtggcgttc aagaagcgcg
    19141 cccgcgatct cagcgccccc agcggattca ccccgtacga gacggtgaac gtcagaccca
    19201 gcagataccc gggcttccac gggcggctcg cgctgctggt cagcgacctg accgtcagcg
    19261 ccggcgagac gacagcgatg accctgctga accgcagccc ggcacccaca ctgatcggcc
    19321 gcgacacaca gggcatcttc tccgaccagc tgtcacgaac cctgcccgga ggcccgtcac
    19381 ttgacctcag caacgaggac taccgcaact ccgccgggca gagtttcgaa ggccgtggtc
    19441 ttcccgtcga cgcccggttc cgtacgcctg tcttcacgtc cgccgagctc gaagacggct
    19501 gtgactccgc ccttgccatg gccctcgacg acctcgggca caggaaggcc ggcacaacac
    19561 ctcggtgccc cacgaagagc ggcggatagg tctggttgtt gatgcgatct cgtcaaggac
    19621 accgtcggcc tgaaggtacg gctactcggc gctgtcacgt tggctggttg agtgggatga
    19681 tcttcgggtt gatcatgctg gagagggttg tccgtggggg acggtcgccg tcgtacaagg
    19741 gccatcggtg cccggtcgag gtgatctccc actgtgtgtg gctgtacttc cggtttccgc
    19801 tgtccttccg tgaggtggag gagctgatgc tcgagcgcgg tgtcgtcgtc tcgcatgaga
    19861 cggtccgccg ctggtgtgcc aagttcgggc agtgctacgc cagcgcgctg cgccgccggc
    19921 agccccggcc gggcgacaag tggcatccgg acgaggtctt gaaacggctg aaggagccac
    19981 acaccatccg agccgtgccg ttcccgtcac gcacctgtgc cgtgcctgtg gcgagcctgt
    20041 gtcattcccg cctcagcctg atatgggcgt ctcagcgcgc ctcgctgacg ctccgtcgaa
    20101 cgttccggct gtcgcatggg cagccctcac tgccggttag gataaaatga cacacaaggg
    20161 acgcatcgtc ttcgtggttg ccctcactac cctggggctc gggctcacgg cctgcaacgg
    20221 cgaggactcg gcaacgacac aggaatcgcc ttcggcctcc gccccggagt cgtccgaccc
    20281 gagcagcaag agcccgtccg cgggcaccgg cgacgacgct gccgctccgg ccggtgatgt
    20341 cgccgcaccg ggcacgaagg tcaagatcgg tgaccgagcg gtcctgccgt tcacgtacgg
    20401 gaccgacaag aagggcacca tcgccgtgac tgtcacggcg atcgagaagg gggccgaggc
    20461 cgacatggcc gccttcggcg acaaggcgaa gggaatgacg ccctactaca tccggatgaa
    20521 ggtggagaac gtcggtggca ccgacctgtc gtacgcgtca ctgaaactgc gcggaaagct
    20581 ggatggcagc ggctccacgg gcgtagttct gatcggcgac ctcccgggca agtgcgacag
    20641 cgaatcggca ccccgcgact tcaccaccaa gggcgcgtcg tacgagacct gctcgctcag
    20701 cgccacgaag accgatccca tcgcggctgc ctcgttcgag gagggtgacg cgtaccgcga
    20761 cagcccggtc ctctggacca gctgaccacc cgttcccgtg tccgcgcgcc gggcatctcg
    20821 tccttgacgg aatgcccggc cggagtccgg cccgcgctct acagctttcc ggcgagcagc
    20881 accgtgcggt ggccgcccag cctgaggccg acctcaccgg tgaaatcgga cgtgagttcc
    20941 gcccagcccc agaacgtgaa cccgaggtgc ccgcacgtag tagtcgtcct cccagctcca
    21001 ccggtcgatc ccgggcggca gggcgcagga cgggccgtgc acgaatcctt cgccccttcc
    21061 tcggcccagt cctggaaccg cccctcaggg gtcccaggcg gactcgatgg gctcccacac
    21121 ctcgtcgccc cctgaccctc cccgccgtag ccgcgctcct gtgcgcgctc cacgacctcg
    21181 acgacctcgc agctatgggc ctgcacccca cccggcacac cacccgcgtc agcgcagcca
    21241 ccaccggcac cacccccgtc accctggaac tgtccgacac atccgaccgg gggaactgac
    21301 gtggccgccc gccgactgcg cctgcttctc cgccacctga ccctgcgcac cctgggaaac
    21361 accgcactcc tccagcagca cccccaccac caggcccacc ggccgccctg cgcaccccgc
    21421 tgcaccgaac agatgccgtg cgtgccccgg ccccgcacgg gcgaggagta ggccgcccgg
    21481 actgcctgcc gcgccgctgt acttccggga tcgcaggatc ggggtgtgga gtccccgatc
    21541 aaggtggcgc tggccaacgc ggtgccggta cggcccgcag gcgacggctg gttctacgag
    21601 ccgaagttcg acatccacag aatggtgctg cgccgcagag gaggacagtg tggtgctgca
    21661 cgcgaggtcc gggcgggtcg tcaccagaag gtccacacca cccaagtgat gacggccagg
    21721 agaactccgg cagccatcaa gggcagaccc cagcgcctcc gacgggcgaa agaaccggag
    21781 tagctcgcgt ggttactcag ggcactgggg ccgtcggccc cctgtgaacc cgcggtttgc
    21841 cccacgatgg ttaccatcgg gccctccctt ggagaccatg tccattctcc ggtctccagc
    21901 cgggcgcctt cccgcagtcc tccgccgccg tcccggcgcc atcggattcc tccggcatcg
    21961 gtgaactcga cgttcaactg catcggtgac cttgtggcgg tctgtgcctg ctgctggggg
    22021 agaggaaagg accgggagct ggacgatggg atgcttcccg agatactcac gacccgggcg
    22081 tcggcgatct gcgcgccaag gtccagaaca ggttggttgc tcaggttggt aaccaagagt
    22141 tcagcagtct gcaggccctc ggcgagagcg gaagacctca tgacgacgcg aatatcgatc
    22201 acggacgctt gggcaagaat ttctgctcga tcga
//
