LOCUS       NZ_LWLE01000014        25275 bp    DNA     linear   CON 27-MAR-2024
DEFINITION  Streptomyces sp. TSRI0281 scaffold21, whole genome shotgun sequence.
ACCESSION   NZ_LWLE01000014
VERSION     NZ_LWLE01000014.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. TSRI0281
  ORGANISM  Streptomyces sp. TSRI0281
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 142484)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 142484)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra,H. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-APR-2016) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2016
            Assembly Method                   :: CLC NGS Cell v. 8.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905125.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:37:03
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,600
            CDSs (total)                      :: 8,518
            Genes (coding)                    :: 8,175
            CDSs (with protein)               :: 8,175
            Genes (RNA)                       :: 82
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 76
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 345
            CDSs (without protein)            :: 343
            Pseudo Genes (ambiguous residues) :: 0 of 345
            Pseudo Genes (frameshifted)       :: 151 of 345
            Pseudo Genes (incomplete)         :: 273 of 345
            Pseudo Genes (internal stop)      :: 33 of 345
            Pseudo Genes (multiple problems)  :: 102 of 345
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:13:17
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 105401
            Orig. end                         :: 130676
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LWLE01000014.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25275
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25275
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25275
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15275](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15275
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            95..1861
                     /locus_tag="A6A29_RS21770"
                     /old_locus_tag="A6A29_37045"
     CDS             95..1861
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003997990.1"
                     /locus_tag="A6A29_RS21770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_37045"
                     /product="relaxase/mobilization nuclease domain-containing
                     protein"
                     /protein_id="WP_073722155.1"
                     /transl_table=11
                     /translation="MVPDVSTGDRSRGLLSYLFGPGRRNEHTDPHIVAAFAMPGINDPG
                     RVPLDQHHGALSELADYLDQPVKLREQRLGKEVPQHVWHCPVRTAPGDRYLTDEEWAEV
                     ARRIVHSTGIAEHGDDAACRWIAVRHAEDHIHIMATSVREDGRRPRNKGDGRRAQAECR
                     RIETELGLRRLKPGDATAPKTPSGPEVAKAERQGRKNTARVWLREHAYAAAAAARDEDE
                     FFAVLTSLGIKVRPRLGPVTGEITGYSLATADDTDIKGELIFYSGSALAPDLSLNRLRE
                     RFGLADGKAAGQATALHTSRADAGASWRQADGELRAAYTLVTRTSGTAGKKADAEVQAQ
                     AAAFAELLHNTAVSAPRQLRAEIQAAAITFNRANRSAIRADHRAADALRQAGRTLLSSP
                     TGGDGDFVAAALTSAVFLLIALSEWHAQRGHAQQAAAAQQSLVHLRAAQQHAARPALAQ
                     LAARAPSPQAQDRLAAAVRATIPEHAHRILADPAWPALSTALAQAESAGTPPRQTLADL
                     SGQRELDSADRPAEVLIWRLRTVTAERVSQRARSAASRSARSTHLTTNKDAPTVPAVQP
                     QPAVASRQRPSR"
     gene            complement(1913..2662)
                     /locus_tag="A6A29_RS21775"
                     /old_locus_tag="A6A29_37050"
     CDS             complement(1913..2662)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014043973.1"
                     /locus_tag="A6A29_RS21775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_37050"
                     /product="IS5/IS1182 family transposase"
                     /protein_id="WP_073722128.1"
                     /transl_table=11
                     /translation="MVPDPAALDLPHALVEWVTMLIVTREGDRRCKLPPHQRALVALVY
                     LRKHDTLAQISAGFGISVGTAHAYTTAVINLLAGQAPGLLKILREREPEYVLLDGTLAE
                     CDRVGDGRADYSHKHRRHGVNVQVVTDQTGHVLWISPALPGRCHDLTAARTHRIIRICE
                     RQGVPVLADRAYTGAGLWVTTGRRRPPGGQLTPTERTVNRALATSRAPVERGIARLKSW
                     RIFRRSRCSPNRMTSIAKAVLTLERQG"
     misc_feature    complement(2790..2802)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.46"
                     /tool="antismash"
     gene            complement(3072..3287)
                     /locus_tag="A6A29_RS44855"
     CDS             complement(3072..3287)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A6A29_RS44855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_143197024.1"
                     /transl_table=11
                     /translation="MTAMVMVESTRSVARISPVMENAFREITADTFTDPDELQARLEEF
                     LDRAMSLKDVPRGPYAFHGPAQESAE"
     gene            complement(3284..4768)
                     /locus_tag="A6A29_RS44860"
     CDS             complement(3284..4768)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A6A29_RS44860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_143197025.1"
                     /transl_table=11
                     /translation="MTESLIARHNKRMMNLPEIPSSAIQPVMSALLSFGLIDMMLRKFG
                     ATRDRHPADYGASWVDHLAWGADSAFVAARLIFSGQFVGASAVLRSQMERWTENVAYNY
                     GVKHISGESAAEFAARAWSRGHEKYPSAIKQESDTNVGSEISELDFWEDERRSLGFQGP
                     SVIVGKDYRVYPGTLMELLSELLHGRGDFIKVLRWDACDLLADEPTELVEASQWLSDVL
                     MLYLRQIRVCLATLAMEQGKPELAPALFALPERIYAGGDAPIPSSLFPLLPQTGLSPDI
                     LERMRSASYAYEEVMRGRRPAGRLFRDGEMVHLHFYERRARAGRWALKALEEEKEKLGD
                     GFNIDGLGGRDSTNVMATEMAGVLSLWLGDSPEGNAAAMCASALRTAHWLWLEDDDRSM
                     AALRVVLEQCARLRVWATKPERQLNSKNLFHPHPRIGSMRQGGADSLPSIGRWVSLRTF
                     MRVFADKVPGKSLWAYNRMGDRRIRFTRPGVTFSKL"
     misc_feature    complement(5235..5249)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.51"
                     /tool="antismash"
     gene            complement(5357..5884)
                     /locus_tag="A6A29_RS21785"
                     /old_locus_tag="A6A29_37055"
     CDS             complement(5357..5884)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012380192.1"
                     /locus_tag="A6A29_RS21785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_37055"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_079182932.1"
                     /transl_table=11
                     /translation="MTRVIDLRHYGQGSLPEGFKQMLIDVHADAYADAMGNEFNQRFPW
                     FVDHWSGMDGFTCVVAFDGDEPTGFAYGAPLQPGREWWRSTAFAPNNGYIATYAVSEVM
                     VRPQWRRQGISERLHEALLKKRGEDLAVLLVDVTHPKVQDLYETWGYEKAGEQQPFADS
                     PVYAVMVKRLHP"
     gene            complement(5881..6753)
                     /locus_tag="A6A29_RS21790"
                     /old_locus_tag="A6A29_37060"
     CDS             complement(5881..6753)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018490586.1"
                     /locus_tag="A6A29_RS21790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_37060"
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_241838594.1"
                     /transl_table=11
                     /translation="MNQLVEADDRQGGHASLATAALEARAKVLELQHRNASERVRRALY
                     ALAAEFTTVAAWSCIDLRDLDKARTYLHESSTFAGLSQDPPTAMRVWVNMAMLAYQRKN
                     WPEQLAAAQAANASLAARRDPFFGSMGRVRLALAHSSLGDLRAARRSLGAAQENYRKAA
                     EDERPRWTAFYGPAELNHLAAIILNHNGEPAEAEAMAHRSLARIPAEFQRNRALATCQL
                     ALAQLRQGEPEQATATAGTVFTIMEGAPLPGRMRTLIGDFHRDLFRLAPSTTYARDWAD
                     RMRDEWSRT"
     gene            7373..7798
                     /locus_tag="A6A29_RS21795"
                     /old_locus_tag="A6A29_37065"
     CDS             7373..7798
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012380190.1"
                     /locus_tag="A6A29_RS21795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_37065"
                     /product="ATP-binding protein"
                     /protein_id="WP_073722157.1"
                     /transl_table=11
                     /translation="MTVAQPNAIGFPGYAAEVPCVRESVSLARAFVSQVLAVWGMDDDV
                     TGWGKIIVTELLANAVEHTETPVSRIHIERPSNGAVRIGVSDRSHDAPHLKTADLTAES
                     GRGLSLVAAMSSQWGYDTHPWGKVTWAVVETPVGRER"
     gene            7795..8214
                     /locus_tag="A6A29_RS21800"
                     /old_locus_tag="A6A29_37070"
     CDS             7795..8214
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012380189.1"
                     /locus_tag="A6A29_RS21800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_37070"
                     /product="DUF6415 family natural product biosynthesis
                     protein"
                     /protein_id="WP_073722132.1"
                     /transl_table=11
                     /translation="MSTAVAPKPPAQEWTSPLDADGLRLVLERFRAWEPLDVEEVFDDL
                     DAAIGSQTPPVATAVALLGRLRRHLKQLSDITVADDSFPPSAEMTRLVERGVPLLEEPT
                     PAGYRQAVGLARRLAFVTADLIEELIEARYIKEIE"
     misc_feature    7861..7863
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            8432..9667
                     /gene="fxlM"
                     /locus_tag="A6A29_RS21805"
                     /old_locus_tag="A6A29_37075"
     CDS             8432..9667
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018490583.1"
                     /locus_tag="A6A29_RS21805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_37075"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_073722133.1"
                     /sec_met_domain="PCMT (E-value: 3.2e-36, bitscore: 117.8,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNTTVEPDEATRLRNKVVDELRAGGDISSSEIEAVMRKVPRHAF
                     IPDTPLDKAYDTYAAVITKTDEHGVQLSSVSAPQIQAMMLEQAQVRPGMRVLEIGSGGL
                     NAAYLAELVGERGEVVTVDIDPVVTERAHRLLDEHGYGWVRVVTADAAEPIPDLGEVDV
                     VMVTAGAWDIAPAWTAQLKQGGRLVVPLRMRGLTRSVAFTQITGEHGPYLESVSALICG
                     FVPMQGSTAHREELLLVNGTPEIGLKFDDGLPADPHRLDNAVTFPRHELWTGVVIGLSE
                     LIDTLQMAMAISLPGFCTMAVDEDLDTGLVAPVNKRFALAAVEDDTFAYLVTRRTEDNK
                     HIEYGVHTLGPNAKQFADQVADVLRDWEASRRGGPSPVIRVYPANTSDDQIPADRVIDK
                     VHSRVSLSWPSA"
     gene            9723..9914
                     /locus_tag="A6A29_RS21810"
                     /old_locus_tag="A6A29_37080"
     CDS             9723..9914
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012380187.1"
                     /locus_tag="A6A29_RS21810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_37080"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_012380187.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 1.7e-16, bitscore:
                     52.7, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSATLAPPAPLAGLDDDFAPLDVKVVIAEHAYGKLMCSTGDGCG
                     TTCATGASACGSFTEDPA"
     gene            10001..13066
                     /locus_tag="A6A29_RS21815"
                     /old_locus_tag="A6A29_37085"
     CDS             10001..13066
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012380186.1"
                     /locus_tag="A6A29_RS21815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_37085"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_073722134.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.4e-201,
                     bitscore: 662.9, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.4e-18,
                     bitscore: 60.2, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.9e-10, bitscore:
                     32.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSRAVADYRWQGAAMLRATTSPEPADIPRTLDLDNVAVTRGWLN
                     RVWECDDFRNAVELATPVLSDAVEAVVQGRQSEPRHVRRTAVSTVSYLLRRQHRPTPLG
                     LFAGTAPVTVGPRASARWRDKHRVLIRPDSEWVTDMVLRLQRIPALLARLPLVANNAAR
                     TRGDRLVAPGPPSDGHAVLLAPVEISVRNARPVAAVMDAARSPIPYGALYGHLRDSFPQ
                     ATPEQIDALLTGLVEQQFLITSLWAPMTTVDPLQHLCHELEQHDADSIPDVRDLVHELY
                     ALRDEVSAHQPTLSDISVSALATRMRALTAVTPTPLLIDTALDCETQLPQTVIAEAQAA
                     VSALYRTTPQPYGYQHWRDYHRRFRARYGVGALVPVMDLVADSGLGLPAGYIGSERGAS
                     LKVRTDRDELLLSLIQQVLLDGRDELRLTDDMVHALEKAAGTDERLFVPRVEAAFEIHA
                     PSTRALSSGTFDLLLTAVPRPGSSMAGRFAHVLPPEHQDALATSYRGAPDRLAAQLVFP
                     PRRHRNENVTRTSRLLPHIIELSGHQERDETTIRLADIAVTADPRSFHLVQLSTGRPID
                     VRVLHALEGGTQTPPLARFLAEVANGRYAAYKPFDFGAGSRLPYLPRVRYRRTILTQAR
                     WLLMAADLPGRKAPRREWEDAFASWRDRLRVPMQVAVIEYDQRLPLDLSHPVHLRVLRA
                     HLDNARRVELREVPDADAHGWIGRAHEIWLSLGRSEPGTPYKPRPRSTTSPGADRHLPG
                     GGDVLHAQLHSHPGRYDEILSHHVPHLLAAFGEEPPTWWFTRHREMARPDADQHLDLTL
                     LLSPDSYGVGAQQARAWADNLHTMGLASGLALAPYQPQAGRFGHGPAMDAAHQVFAADS
                     AAALAQIQLAERTDAFARQALAAASALHLVTPLAPNAAAAEEWLVGNLPQGTGRLDRTL
                     RSQVLELTGPNGASALAPLPGGQQVTEAWRARAAAVDFYRTALVSERNPLDVARSLLHQ
                     HHVRTLGVDPRTEETTIRLVRTAALQHRMADR"
     misc_feature    10448..10450
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        10469..10744
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_A6A29_RS21815_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="3.70E-19"
                     /identifier="RREFam001.1"
                     /label="A6A29_RS21815"
                     /locus_tag="A6A29_RS21815"
                     /protein_end="248"
                     /protein_start="156"
                     /score="60.2"
                     /tool="antismash"
                     /translation="VANNAARTRGDRLVAPGPPSDGHAVLLAPVEISVRNARPVAAVMD
                     AARSPIPYGALYGHLRDSFPQATPEQIDALLTGLVEQQFLITSLWAP"
     gene            13063..14295
                     /locus_tag="A6A29_RS21820"
                     /old_locus_tag="A6A29_37090"
     CDS             13063..14295
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018490581.1"
                     /locus_tag="A6A29_RS21820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_37090"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_073722135.1"
                     /sec_met_domain="LANC_like (E-value: 2.3e-42, bitscore:
                     137.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTLATTAATALEQYTADLAEPPPPPPEEPWAVQSLADGAAGISL
                     LHIEIASRYGGSWRSAHRWITSAASGPISAADQTGLFLGAPAVGFVLTAVPRAYQHLYV
                     SARTTLHQHITDLANRRVDAALARIDRGDLPTFAEYDLFYGLTGIGAYLLRTEPEGTAL
                     ERILQYLVALTRPLAADRRGLPGWWVRHDPARGESPHFPGGHGNFGAAHGITGPLLLLA
                     QAMRRGITVRGHQDAMFTICAHLDAWCQHGDYGPWWPEHISRRDHDRGQPHHDAPARPS
                     WCYGTTGIARAGQLAGIALRSPTLQNFYEDALYRTLSDPAQLALVTDSGLCHGWAGIYQ
                     TAHRAAADALDPRLHALPERFGDALAASGRSSSLSDPGLINGAAGTALALTTLASQQAP
                     STGWDTCLLIN"
     gene            14277..15275
                     /locus_tag="A6A29_RS21825"
                     /old_locus_tag="A6A29_37095"
     CDS             14277..15275
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018490580.1"
                     /locus_tag="A6A29_RS21825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_37095"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_073722136.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 9.4e-34, bitscore:
                     110.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLDQLIQTTEPSPTQHAVLAVLTGLPLADAAQQYRIDPVVLSDA
                     VAVYDQAGREALARHAAITDWWQTYLHFTDWPNADTTFTTHVLPILREAEAARAIDGWW
                     YTRKHPCWRLRLRVQPAGGAKLTIGDGFDRLVSDGHLQRWWPGIYEPETPAFGGKTSMT
                     AAHALFVTDSREIQLLRQRDDLTVGPRELSVLLCTIMMRAARLEWYEQGDVWDRVITTE
                     HRSAVSDVPPEQLDARVQEIRPLLLADSDVLLRPGGPLEPVAEWVAAFHNAGQALADGV
                     RDGTLDRGLRQVLSYHVIFHWNRLGLSMRGQSILAWAARAAILCGNGHKEG"
     gene            complement(15301..18027)
                     /locus_tag="A6A29_RS21830"
                     /old_locus_tag="A6A29_37100"
     CDS             complement(15301..18027)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024511.4"
                     /locus_tag="A6A29_RS21830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_37100"
                     /product="DUF3962 domain-containing protein"
                     /protein_id="WP_073722137.1"
                     /transl_table=11
                     /translation="MYHLISTTAYEPDMDREPWAEQYRVISFPEEWRAEFMDLYRRRWR
                     RREQPTALPISKLNDLLRATAPGLVATGRGAGSNAEVPWFYASEEMPAELISPLLASWV
                     MTLPPGTDPEPERMANHRAALDRALALIDDYTPQWRTESVDLTAADHSPGGTAHPDRRL
                     YQLLPERIGARLASSPLRLNGVDLSFRLVTRDQGVELVSWPPRSYAKGKHTWFYSGLVT
                     VTVQTVPFAPRFRVHVSYGIRRWATGSPVWLPEGHGATVLLDAPLPWPGVHGPRRRLTA
                     NSLAYDRSLGMLAWSRQSLVGLLPELDVTRAYPKPSDLVAEPVGWIEGQNGVAAGILHS
                     TAMGRHGVGAGLMPLERSLLDHWVEEGIGPFLRRVPELERVHRKSKPVLLPTSPTKDQA
                     EQEKRARNRIQARRDAVRATLDGRPLLVDVLWQTEETRDALVAALREWLGLSAGSCGVD
                     GEHEWQDGELRVRLRTRPLGTLGAPLEVIRKSGHKRAQALAQAVRERAARTTGHFVPPP
                     ASEGLVIVETLGPERFPVRDSDPKSALRLGCAVARRVSQFIVVPEDSDGAVAHRAKSAV
                     ADGMRQLGAVVPPDQRLDDKLADGLQYLALWYVRCQADGPTRQAGQRLVALRIRPRDPV
                     HPVCGWDDTRKKWLPYAQLLLALAADEFTSDHPTQIRSARAFSTQDERRDEVERQVRSL
                     LYQVRDRPTLLLVNSGNLRGVWPGLNNGQLVRDMVTLHGEQLTRLALYGGGLRAVLIRD
                     ANSRGETPEWYAPGETDEEPPGFSAGLWAAREASPDNRVFVSTVGKPPTAGTVRRDLRK
                     LVPDKDWPHGPAATAWNPQALELTVLGCLSEAALAAGGSPGATPERPAVIAAAVHQLRF
                     HDEYHPLARPLPLHLAKLAEEYFLPLAPAPATEQVDE"
     gene            complement(18015..21548)
                     /locus_tag="A6A29_RS21835"
                     /old_locus_tag="A6A29_37105"
     CDS             complement(18015..21548)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037741.4"
                     /locus_tag="A6A29_RS21835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_37105"
                     /product="hypothetical protein"
                     /protein_id="WP_158074434.1"
                     /transl_table=11
                     /translation="MVVPLSDAAPKMKTARLVSLCEIEVGLLLQETFAAEAPAEDAWTL
                     FSGYPFARAWRAVDAVGERTLRTARHTVWTWGRRRAWTEALQDYQLLDRQLRGYEVADL
                     SLPAVRRRSLSVAPDRWDAYERLLREAPAFAGRPMVIAAAGGHTFPIGRHQATVQLPES
                     ALPSPVEHDFATLPENGGKPLSFLWGDLLETAAYMDSVKSENWAGRLGAVHLFTRQADG
                     FRCADRFEVRRIQHLLGIVGAGKSTLRDVLAVHMARQGMRATIVVGDVAEQLKMVERYN
                     TYVPRSAAPVLGASGRQRHAERLHRRLAGRGRRNLLAHDDPAFAYLSTSCALNALRYAE
                     GQLADDLLGFGEAPCARLQKPSRRDPAGDLWERRQLACPFWSACPRHHGARELVGAALW
                     VATPPSLVDSKVPHPQNPERVRYLELACRRSDLVIIDEADRVQMQLDRMFAPAIPLIGG
                     GSDTRSFLHDVNQHRIRELAGAGGIQLSDRDVENWSAAVNTTQTAADRLVAMLVRDVEL
                     RNWVRTGYFSAWTLQLRLVEERYPLPEDREGTSAEALGPAVGHRHRAPRLRLTEILDAF
                     RENPFGDRQRYTEDGVELTALLGELLHTNRRETTRERLEEMVCRLFALDPLLEPTAEAS
                     EQYEELRHLAAAERPRAPQPPGKSRKRARRLKKEPLPENSDDWLKLLVTRFEFTMLLSA
                     LEPRLALINAMWPRVASALNLGFNEMYRRPLDYGPMVPEAPMGNVIGFQFLMDSPDHGG
                     VRTGELRFFRCSGVGRELLREMPDLPTVDGRPGTNVLLMSGSSWAGKSSRYHIPVEIGV
                     IIEPGPEDLDRIAEQSEFRFEFIRSVCGCRAGCTCDGQYDAQRLSGEPLDQRQEILRRM
                     AVALGDEDAGISRLREELQRLPESRRHILLLVGSYEESKVVADTLHTLNRRWKCRVRRL
                     VSDDDPEAGVLGEGDEHHAPILRRGDVETLASTRAEILVAPLLAVERGHNILDLDRDHA
                     AIGSIYFLARPNPRPDDLGLAVHAINDWIVRAMRGGAFDEWVRSEPSLGLGARKVRDLA
                     RSQWYRVLARSMAWSSLGDDREAITWDLLVLIWQVIGRSVRGAVPTRVAFVDATFSPHL
                     AAGGASQEPDTPKSSLLHSIHSVLEPYFTPGTDVPADDRHIVRALYRPMWTALDRCLHP
                     SPNEGNTACIT"
     misc_feature    complement(18882..18884)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(21571..22629)
                     /locus_tag="A6A29_RS44865"
     CDS             complement(21571..22629)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF036722.4"
                     /locus_tag="A6A29_RS44865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_143197027.1"
                     /transl_table=11
                     /translation="MTEDGQAIALLAAVARGVLELTSINRSAALRLPYPPGVQLVLDQV
                     VLSGMTRSHPVPAGVPDLMRWCRERGPEEWVPGLPDEFLTVGTRLIHPEAGEPTRTCVE
                     LASLGPYGVPEREAETLLAELAAACGTVERFAACRDFLIDRPVMLRPDPMQLMQPAVAQ
                     VWNLVKGLYGPVPDRFPDAGLLHCCRDCGLLAKYVTAGRPWCEGGCSSGDRELETSQGS
                     QSALALPFALRLFLALPGRTEQTVRSRLTDQVQLLPLGLGVHRVTSPDGTLRVFQVYDR
                     EQPGLAALRAAEVATLLDGPLDIVMPDAMAGRPGCRRRFDLALPVGAQVRLVAASDFTT
                     PGPAHRSRRNRA"
     misc_feature    complement(22393..22395)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(22626..24215)
                     /locus_tag="A6A29_RS21845"
                     /old_locus_tag="A6A29_37115"
     CDS             complement(22626..24215)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014139817.1"
                     /locus_tag="A6A29_RS21845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_37115"
                     /product="PD-(D/E)XK nuclease family protein"
                     /protein_id="WP_079182933.1"
                     /transl_table=11
                     /translation="MTETWPPDGLIGGSTTVTLRLSMFGPERYRCPASDVLKARGMRPR
                     VRPAWKPEVLDPFPNGPFMAAADELDRPADESSPNPPSGGRQRPLHDGVRQWTEHALLM
                     YRKAFPTDSVPNSALHLAPNPWVYKHQRAAGDGQAAVEYRITAWGRCLESPDGRRRELR
                     LPVVKRLRTRSDTERAIAALVAAEGNPDPRLEEVRVVQFALSDGRTAPIFEGSRAEALT
                     LYRRDGAPAVRALLGSQEYRPGTACVSCAIAPVCPTLPKTAGLLGTADRSQPRRSWSST
                     TGRGHQSCPARGYLRGLRLPADDTVERGTAAERGRALHAFLAERHERQSRTPCTPEIPR
                     DWVPEGYRLPDEERQLGADLLRHHAEVCPLHTAEPESEIRIEPRMAFDDTAADLLVLAE
                     PDLLYRSEGSWVWRETKTSASDRPRRDLLAAYPQLALAVKIIGSGVLSGPQVRGRVELE
                     LLRPAGADLRTIDPFAPATLAVAEAVLREQVEGWHTETLFEAVPGPECAHCEVARWCSV
                     RQSQQVGSEEGQ"
     misc_feature    complement(23421..23423)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            24295..25185
                     /locus_tag="A6A29_RS21850"
     CDS             24295..25185
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF019334.4"
                     /locus_tag="A6A29_RS21850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_073722139.1"
                     /sec_met_domain="Pkinase (E-value: 2.7e-30, bitscore: 98.4,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLPGTFLDGRYRVLRKLGHGGEGELFVARDELDRCEVAVKAQFPR
                     TFESTKTYASAAFALEDELERLTFMRHVPGIPEVLGDGYYGRHRGRYIVMELVQGDTIA
                     SWISDHHPVPAAAAVSVVAQLCDILHGVHREGYVHRDVSAKNAMMQPSGKVRLLDVGIS
                     GPIGEINSDPRGTPGYAPPEQYDNKALLTPQVDVFSLGTMLFAMVGAELPYSGLEGPPD
                     ATTPAFPNGFRAHMSNTLQSLALAMVSIDPGERPDLAALRNYLRPMLPTPRCPASPKAT
                     RPDPTTPYRLGLSLP"
ORIGIN
        1 cccgaccgag ccgaagacac cctcagcgag ttgcaccagg tcgcccaacg cgctcgcctg
       61 ctgctggacc aagccctcgc caggggtggt cgccgtggtg cctgacgtct ccacgggtga
      121 ccgcagccgt ggcctcctgt cctacctctt cggccccggc cgccgtaacg agcacaccga
      181 cccgcacatc gtcgccgcgt tcgcgatgcc cggcatcaac gatcccggcc gtgttcccct
      241 cgaccagcac cacggagccc tcagcgagct ggccgactac ctcgaccaac ccgtgaagct
      301 gcgcgaacag cggctgggaa aggaggtgcc acagcacgta tggcactgcc ccgtccgtac
      361 cgcgcctggc gaccgttacc tcaccgacga agagtgggca gaggtcgccc gccgcatcgt
      421 ccactccacg gggatcgccg aacacggcga cgacgccgcg tgcaggtgga tcgctgtacg
      481 gcacgccgag gaccacattc acatcatggc gaccagcgtc cgcgaagacg gccgtcgccc
      541 ccgcaacaag ggagacggcc gacgggccca ggccgaatgc cgcaggatcg agaccgagct
      601 cggtctacgt cggttgaagc ccggagacgc gaccgcgccg aagacgccgt ccgggccgga
      661 agtcgccaag gccgaacgac agggccgcaa gaacacagcc cgggtctggc ttcgcgagca
      721 cgcctacgcc gccgcggcgg cagcgcgtga cgaggacgag ttcttcgccg tactgacgtc
      781 tctcgggatc aaggtccgcc cccgtctcgg tcccgtcacc ggggagataa ccggctacag
      841 cctcgccacc gctgacgaca ccgatatcaa gggcgagctc atcttctaca gcggctccgc
      901 actcgctccg gacctgtccc tgaaccggct tcgtgagcgc ttcggcctgg ccgatggcaa
      961 ggctgccggg caggccacgg cgttgcacac gagccgtgcg gacgcaggcg cctcctggcg
     1021 gcaagccgat ggggagctgc gcgccgccta cacgctcgtc accaggacca gtggaacggc
     1081 aggaaaaaag gccgacgccg aagtgcaggc tcaggctgcg gcatttgccg agctgttgca
     1141 caacaccgca gtctctgcgc cgcgccagct ccgggcagaa atacaagcgg cagccatcac
     1201 cttcaaccgc gccaaccgct ccgccatccg agccgaccat cgggccgccg acgccctacg
     1261 tcaggccgga aggacgctgc tgtcctcgcc caccggcggg gacggcgact tcgtcgccgc
     1321 agcgctcacc tctgccgtat tcctgctcat cgccctcagc gagtggcacg cccagcgcgg
     1381 tcacgcgcag caggcggcag cggcccagca gtccctcgtc caccttcgag ccgcccaaca
     1441 gcacgccgcc cggccggccc tcgcccagct cgccgcacgt gccccgagtc cccaggcaca
     1501 ggatcggctc gccgcagccg tccgagccac gatccccgag cacgcgcatc gcatcctcgc
     1561 cgacccggct tggcccgcgc tgtccaccgc cctcgcccaa gccgagtccg ccggcacccc
     1621 gccccgccag accttggccg acctgtccgg gcaacgggaa ctcgactccg cggaccggcc
     1681 agccgaagtc ctgatctggc gcttgcggac cgtcaccgcc gagcgagtaa gccagcgggc
     1741 tcggagcgcg gcaagccgca gtgctcgcag cacccacctg acgacgaaca aggacgcacc
     1801 caccgttcca gccgtacagc cgcagccagc ggtcgcgagt cgccagcgtc caagccgctg
     1861 atatcgccct tcctcagact gggaacttgc tgccgcgctt cagtgagcat tttcagccct
     1921 gcctctccag ggtgaggacg gccttggcga ttgacgtcat tcgattcggg ctgcatcgtg
     1981 atcttcggaa gatccgccag gacttgagtc gcgctatccc acgttcgacg ggcgctcggg
     2041 acgtggccag tgcacggttg accgtccgtt ctgtcggggt cagctgcccg ccgggcgggc
     2101 gtctgcgacc ggtggtgacc cagaggccgg cgcccgtgta ggcgcggtct gccaggacag
     2161 ggacgccctg gcgttcgcag atccggatga tccggtgggt gcgggccgcg gtcaggtcgt
     2221 ggcaccggcc cggcaaggcc ggcgagatcc acagcacgtg cccggtctga tcggtcacga
     2281 cctgcacgtt cacgccgtgg cggcggtgct tgtgcgagta gtcggcccgg ccgtcgccca
     2341 cgcggtcgca ctcggcgagc gttccgtcga gcaggacgta ctcgggttcc cgctcgcgca
     2401 ggatcttgag caggccaggg gcctgaccag cgagaaggtt gatcacggcc gtggtgtagg
     2461 catgggcggt gccgaccgag atgccgaagc cggcggagat ctgagccagg gtgtcgtgct
     2521 tgcgcaggta caccagagcg acgagcgcgc gttggtgcgg cgggagcttg cagcggcggt
     2581 caccctcgcg ggtgacgatg agcatcgtga cccactcgac caacgcatga ggcaggtcga
     2641 gtgcggcagg atcaggaacc aacgaggcac ctgcgctcat gagttgagac gtcgaacacc
     2701 tccctcaacg gcacgggtgc ctcgtgcgtt gcggccagtc tggccgtcac cccatcagtg
     2761 gccactctga aaaagctcag taaggaggcg cgacagcggc actttcaacc cgcttccgct
     2821 gagctatttc agcgtttcct ctccagggca gggacagcgg cggcaataac ggacatgcgg
     2881 ttgggaatgc aacgagctct gcgcgaggct tctacgcggc tgagttgaat cgtcgactat
     2941 atctctcaac ggcacagaag cctcgtgcgt tgcggtacgt cggccagtcc cgcaatcagt
     3001 ggccactatg gaagaactca cttattagag gccctgcaga agcaccagaa gtacggataa
     3061 ctctattcca tctattcggc agactcctgc gccgggccat ggaaggcata cggaccccgt
     3121 ggaacatcct tcaggctcat tgcccgatca agaaattcct ctagccttgc ttgcagttca
     3181 tcgggatccg tgaaggtgtc tgcggtaatt tcacgaaagg cattctccat caccggcgaa
     3241 attcgggcaa cgcttctggt tgactccacc atcaccatgg cagtcatagt ttcgagaatg
     3301 tgaccccggg ccgtgtaaat cgaatccggc gatcccccat tcgattgtac gcccacaagg
     3361 atttcccagg caccttgtct gcgaatacgc gcatgaaagt gcgcaaactc acccaacgcc
     3421 ctattgaggg gagcgagtcg gcgccaccct gccgcattga cccaatcctt gggtgtggat
     3481 gaaagagatt cttcgagttt agctgccttt ccggcttagt ggcccacacc cgaagcctag
     3541 cgcattgctc cagaaccacc cgcaaggcag ccatcgatcg atcatcgtcc tcaagccaca
     3601 gccagtgggc ggtccgaagc gccgacgcac acatcgccgc agcattccct tcgggtgaat
     3661 ccccaagcca caaggacaag acaccagcca tctcggtggc catcacattc gtcgagtcgc
     3721 gaccacccaa accatcaata ttgaagccgt cgcccagctt ctccttttct tcttccagcg
     3781 ccttcaacgc ccagcgtccc gcacgcgcac gacgctcata gaagtgcagg tgaaccattt
     3841 cgccgtcgcg gaagagccgt ccagccgggc gccttcccct cattacttcc tcgtaggcgt
     3901 acgacgcact ccgcatccgc tcaagaatgt ccggggagag tccagtttgc ggaagcagcg
     3961 gaaacaggct tgacgggatg ggggcatccc ctcccgcgta aatacgttcc ggaagcgcga
     4021 aaagagccgg agcgagctca ggtttcccct gttccattgc cagggtcgct aggcacaccc
     4081 gaatctgccg cagatacaac atgaggacgt cggatagcca ttgcgaagct tcaacaagtt
     4141 ccgtcggctc atcggcgaga agatcgcatg cgtcccaccg caacaccttg ataaagtcgc
     4201 ctctaccatg caagagctct gagagcagct ccattagggt gccgggatat acgcgatagt
     4261 ccttaccgac gatcaccgag ggcccctgaa accccagaga cctccgctca tcctcccaga
     4321 aatcgagttc ggaaatctcg gatccaacat tcgtgtcaga ctcttgcttt atagcagacg
     4381 gatacttttc gtggccacgc gaccaggcac gggcggcgaa ttctgcagca ctctcgccag
     4441 agatgtgttt aacgccgtag ttgtacgcta cgttttcggt ccatctctcc atctgtgagc
     4501 gcaagacagc agacgctccc acgaactgcc cactgaaaat gagccgtgcg gcaacaaatg
     4561 cactatcagc accccaggcc aaatgatcca cccatgatgc tccgtaatcg gctggatgcc
     4621 gatctcgagt cgccccaaat tttcgcagca tcatgtcgat tagaccaaaa gacagcaacg
     4681 ctgacatcac aggttggatg gcgctggatg ggatctcggg aagattcatc atgcgcttgt
     4741 tatggcgagc aatcagggac tcggtcacat gcctagtctc ctgttgcgca attcgctcgt
     4801 actcggagag tgaggaaccc cggcgacctc cacgtcgttc ggccctattt gcgcgacgtc
     4861 tctccctgcg cgcttgttcc tgctctgaca ccggcggctg acgcaattca gccctgcgct
     4921 tgcttgcctt gcccacgtag actccaaaag gctcgatgcc tgctagtggc agagtgacgt
     4981 agatgcgcac gcgtcgctag ctatttttcc cgtatttgca cggcgaacaa cagtaggggg
     5041 ccggggcagg gccttcgttc tctttcagag cggccactgc tcgggggacc ggtcagggta
     5101 ccgaaaggca tgaggctccc gtgccactga gagaagtctt cgacgaccac cccaatagct
     5161 tagaagcctc gtcggtttcc tatcctgcct cactcggcct gcctcatacc ctggtcgagt
     5221 ggctaaccgt gctgatcgtc gcccgtgatg gtgaccgccg ctgcataagg agggtgcagg
     5281 cacggcccgc ggccgacatg atcacgagcc gggcctgcac gcaaggccgg aagtgggtga
     5341 ctcggatcag ggcggctcac gggtgcaacc tcttcaccat gaccgcgtac accggggagt
     5401 cagcgaaggg ctgctgctca cccgccttct cgtagcccca cgtctcgtac aggtcctgaa
     5461 ccttcgggtg cgtcacgtcg accaagagca ccgcaaggtc ttcgccgcgt ttcttcagca
     5521 gggcttcgtg gagccgctcc gagatccctt gcctccgcca ctgcgggcgc accatgacct
     5581 cggagactgc gtaggtcgcg atgtagccgt tgttcggcgc gaacgccgtg gaacgccacc
     5641 actcacggcc cggctggagc ggggcgccgt acgcgaagcc ggtcggctcg tcaccgtcga
     5701 aggcgacgac gcaggtgaag ccgtccattc ctgaccagtg atcgacgaac cacgggaacc
     5761 gctggttgaa ctcgttgccc atcgcgtcgg cgtaggcgtc ggcgtgcacg tcgatcagca
     5821 tctgcttgaa gccctcgggg aggcttccct gtccgtagtg ccgcaggtcg atcaccctgg
     5881 tcacgttcgg ctccattcat ctcgcatgcg gtctgcccag tcgcgggcgt acgtcgtcga
     5941 cggcgccagc cggaacaggt ctcggtggaa gtctccgatc agggtgcgca tgcggcccgg
     6001 tagtggagcg ccctccatga tcgtgaagac ggtgcccgcg gtcgccgtgg cctgctcggg
     6061 ctcgccctgg cggagttgcg ccagggcgag ctggcaggtg gccagcgcgc ggttgcgctg
     6121 gaactccgcc gggatcctgg ccagggatcg gtgagccatc gcctcggctt cggcgggctc
     6181 cccgttgtgg ttgaggatga tcgccgcgag gtggttgagt tccgccggcc cgtagaacgc
     6241 ggtccatcgg gggcgctcgt cctcggccgc cttgcggtag ttctcctgcg ctgcgcccaa
     6301 ggaccggcga gcggcccgca ggtctcccag cgacgagtgt gcgagcgcga gacggacgcg
     6361 gcccatggag ccgaagaacg ggtctctgcg ggcagctaga gaggcgttgg ccgcctgagc
     6421 tgcggcaagt tgttccggcc agttcttccg ctggtaggcg agcatggcca tgttgaccca
     6481 cacgcgcatg gccgtgggcg ggtcctggga gaggccggcg aacgtggacg actcgtgcag
     6541 gtacgtccgg gccttgtcca ggtcgcgtag gtcgatgcac gaccaggcgg cgacggtggt
     6601 gaactcggcc gcgagcgcgt acagggcacg gcgtacacgt tcgctggcgt tccggtgctg
     6661 aagctccagc acctttgcgc gagcttcgag ggctgcggtc gccagggagg cgtgcccgcc
     6721 ttggcggtcg tcggcctcca cgagctggtt catgctggcc gatgctcggg ccacgtccgt
     6781 catgcccacc gaccgacgtt gcttgaccac gggaacgact gcggttgccg tcccggtggt
     6841 ggaagcgatg aagtcgcgac gccgcacagg gccctccggg ggatgttgca tggagctggg
     6901 tgcgctgaac cctaagtccg ccacggggca gccgaacaca cgctcaagtg cggcgcaagt
     6961 gcgtccgatt gggcgtcggc ttgatccgtt gagcaggttg cgcaccgtcc gggaggagat
     7021 gtcgccaggc cgaccggtga tctcctgaag cgcggcgttc aggcgtgccg ccaactcctc
     7081 ctgcgtcaga ctgagttgat taagtcggcc ctgaagaacg agatttcctc ccatgcaccg
     7141 aacgtagtac cgccgtcacg ctggcaccta gagctcgggt aatagaaacg taaagtcttc
     7201 cggttggtgg acgtgcacga atccgggact cttcctgttg cgctgcactc atcgctcgtt
     7261 gactggtcat cggtcgccaa gccgggttcg gtgcggcggc acggaggaaa gcccggtcct
     7321 gccttgcttg cccggaccgg gaaccccagc cggagggaaa gacctcgtga ccatgaccgt
     7381 cgctcaaccg aatgcgatcg gcttcccggg ctacgccgca gaggtgcctt gcgtacgtga
     7441 gtccgtgagc ctcgcccgcg ctttcgtctc ccaggtgctg gcggtctggg gcatggacga
     7501 cgacgtgacc ggctggggaa agatcatcgt cactgaactg ctggccaacg ccgtcgagca
     7561 caccgagacc ccggtgtcgc gaatccacat cgagcgtccg agcaacggtg ccgtccgcat
     7621 cggagtctcc gaccgctcgc acgacgctcc ccacctgaag acggccgacc tgacggctga
     7681 gagcggccgg ggtctgagtc tggtcgcggc gatgagttcg cagtggggct acgacacgca
     7741 cccgtggggc aaggtcacct gggctgtggt cgagactccc gtggggagag agcggtgagc
     7801 acagcagtgg ctccaaaacc tccagcccag gaatggacgt caccgctcga cgcggacggt
     7861 ttacggctcg tgctggagcg gttccgggcg tgggaacccc tcgacgtcga ggaggtcttc
     7921 gacgacctcg acgcggcgat cggcagtcag acaccgcctg ttgcaacggc tgtcgccctg
     7981 ctcggccgcc tccgcagaca cctgaagcag ctcagcgaca tcacggtggc tgacgacagc
     8041 ttcccgccca gtgccgagat gacccgactt gtcgagcgag gagtccctct gctggaggag
     8101 cccactccgg ccggctatcg gcaggctgtc ggactcgccc gccgtctcgc cttcgtgacc
     8161 gctgacctga tcgaagagct gatcgaggcc cgctacatca aggagatcga gtgacacacg
     8221 ccccttgcca cccgccagcc acccagcggg ctggtcgaca cgaaccggcc cgccgggcag
     8281 ccctccgcgg gcgtggtcct cccagctcgc cgtccagcgc ggccccgtcg gtcagccgac
     8341 gagaaccgag cgcgttcgca cccggtttcc ccggcccatc cggcacgcga cgccggcctg
     8401 cgtcccccat acgtacgact gaaggaagtc catgacgaac acgaccgtcg agcccgacga
     8461 agcgacccgt ctccggaaca aggtggtgga cgagctgcgc gcaggcggcg acatctcctc
     8521 ctcggagatc gaagccgtga tgcgcaaggt gcctcggcac gcattcattc ccgacacccc
     8581 gctggacaag gcgtacgaca cgtacgcggc ggtgatcacc aagacggacg aacacggtgt
     8641 gcagctcagc tcagtctccg ccccgcagat ccaggcgatg atgctggagc aggcccaagt
     8701 gaggcccggt atgcgcgtgt tggagatcgg ttcgggcggc ctgaacgccg cctacctcgc
     8761 cgagctcgtg ggtgagcgcg gcgaggtcgt caccgtggac atcgaccccg tcgtcaccga
     8821 gcgggcgcac cggctcttgg acgagcacgg ctacggctgg gtgcgcgtcg tcaccgccga
     8881 cgccgccgag cccattccgg acctcggcga ggtcgacgtc gttatggtga cagccggggc
     8941 ctgggacatc gccccggcgt ggaccgcgca gctcaagcag ggcggtcgac ttgtggtgcc
     9001 gctacggatg cgtggcctga cccggtcggt cgccttcacg cagatcacgg gcgaacacgg
     9061 cccgtacctg gagagcgtgt cggcgctcat ctgcggcttc gtcccgatgc agggctcgac
     9121 agcccaccgg gaagaacttc ttctcgtcaa cggcacaccg gagatcgggc tgaagttcga
     9181 tgacgggcta ccggccgacc cacaccgact ggacaacgcg gtcacgttcc cgcgccacga
     9241 gctgtggaca ggcgtcgtca tcggcctctc ggaactcatc gacaccctcc agatggccat
     9301 ggccatcagc ctgcccggct tctgcacgat ggccgtcgac gaggacctgg acacgggcct
     9361 ggtcgccccc gtgaacaagc ggttcgccct cgccgccgtc gaggacgaca ccttcgccta
     9421 cctcgtcacc cgccgcaccg aggacaacaa gcacatcgaa tacggcgtgc acaccctcgg
     9481 cccgaacgcg aagcagttcg ccgaccaggt cgccgacgtg ctccgcgact gggaggccag
     9541 ccggcgcggg ggccccagcc cggtcatccg ggtctatccg gccaacacct ctgatgacca
     9601 gatcccggcc gaccgggtca tcgacaaggt gcacagccgg gtctcgctct cctggccctc
     9661 ggcgtaacgc cggaagccag gttgttccac accatccgga caccaagaag aaaggcacga
     9721 acatgacgag cgccactctg gcccctcccg ccccgctggc gggcctggac gacgacttcg
     9781 cacccctgga cgtgaaggtc gtcatcgccg agcacgcgta cggcaagctc atgtgctcca
     9841 cgggcgacgg ctgcggcacc acctgcgcga ccggcgcctc cgcctgcggc tccttcacgg
     9901 aggacccggc ctgatccagg ccgttccctg ccggtggggc gagcgaagtg ttccgctcgg
     9961 cccaccggct cctcacccgc cccgccagac ggagggcccc atggtttccc gagcagtcgc
    10021 cgactaccga tggcagggcg ccgccatgct gcgcgccacc accagccccg agccggcaga
    10081 catcccccgt accctcgacc tggacaacgt ggccgtcact cgcgggtggc tgaaccgcgt
    10141 ctgggagtgc gatgacttcc gcaacgcggt ggagctggcc acccccgtcc tgtccgacgc
    10201 cgtcgaagca gtcgtccaag gccggcagtc cgagccccgt cacgtccgcc gcaccgcggt
    10261 atcgacggtc tcctacctct tgcggcggca acaccgaccg accccgctgg gcctgttcgc
    10321 cggcaccgct ccggtgacgg tagggcccag ggcaagcgcg cggtggcgcg acaagcaccg
    10381 cgtgctgatc cggccggact ccgaatgggt caccgacatg gtcctccggc tccagcgcat
    10441 ccccgcgtta ctggcgcggc tcccgctcgt cgccaacaac gccgcccgca cgcggggcga
    10501 tcggctcgtg gcgccgggcc cgccctccga cgggcacgcc gtcctgctgg ccccggtcga
    10561 gatatccgtc cgcaatgccc ggccggtggc cgccgtcatg gacgccgccc gctcgcccat
    10621 cccttacggc gccttgtacg gccacctgcg cgacagcttc ccccaggcca caccggagca
    10681 gatcgacgcg cttctcaccg gcctggtcga gcagcagttc ctcatcacca gcctgtgggc
    10741 acccatgacc accgtggacc ccctccagca cctgtgccac gaactggaac agcacgacgc
    10801 agacagcatc cctgacgtgc gggacctggt acacgagctg tacgcactac gcgacgaggt
    10861 atccgcccac cagccgacac tctccgacat cagcgtgagc gccctcgcca cacggatgcg
    10921 cgccctcacc gccgtcaccc cgacaccgtt gctcattgac accgccctcg actgcgagac
    10981 ccagctcccg cagaccgtga tcgcggaagc gcaggcagcc gtgtcagccc tctaccggac
    11041 caccccgcag ccctacggct atcagcactg gcgcgactac caccgccggt tccgggcccg
    11101 gtacggcgtc ggcgccctgg tgccggtgat ggacctggtt gccgacagcg gcctcgggct
    11161 gcccgccgga tacatcggct ccgaacgcgg agcctccctg aaggtgcgca cagaccgcga
    11221 cgagctgctg ctctcgctga tacagcaagt cctcctcgac ggccgcgacg aactgcggct
    11281 gacggacgac atggtccatg ccctggagaa ggccgccgga acggacgagc ggctgttcgt
    11341 gccccgagtg gaggccgcct tcgagatcca cgcccccagc acccgggcgc tgtccagcgg
    11401 cacgttcgac ctcctgctca cggcggtgcc ccgccccggc agcagcatgg cgggccggtt
    11461 cgcccacgtc ctgccgcccg agcaccaaga cgccctcgcc accagctatc gcggggcacc
    11521 ggaccgcctc gcggcgcagc tcgtgttccc accgcgtcgg caccgcaacg agaacgtcac
    11581 ccgcacatca cgactgctgc cgcacatcat cgagctgtcc ggccaccagg agcgcgacga
    11641 gacgacgatc cggctcgccg acatcgccgt aaccgccgac ccgcgcagtt tccatctcgt
    11701 gcagctctcc accggccggc ccatcgacgt gcgggtcctg cacgccttgg aaggcggaac
    11761 ccagaccccg ccgctggccc ggttcctggc agaggtggcc aacggacggt acgccgccta
    11821 caagccgttc gacttcggtg ccggttctcg gctcccgtac ctcccccggg tccgctaccg
    11881 ccgcaccatc ctcacgcagg cccgatggct gctgatggcg gcagacctgc ccggccgcaa
    11941 agccccgagg cgggagtggg aggacgcctt cgcctcctgg cgggaccggc tgcgggtccc
    12001 gatgcaggtc gccgtcatcg agtacgacca gcgcctcccg ctcgacctgt cccacccggt
    12061 ccacctccgg gtcctgcgcg cccacctcga caacgcccgg cgcgtggagc tgcgcgaggt
    12121 accggacgca gacgcccacg gctggatcgg acgggcacac gagatctggc tctcgctggg
    12181 ccgttccgag ccgggcaccc cgtacaagcc ccggccgcgc tccaccacgt cgccgggcgc
    12241 cgaccggcat ctgccgggcg gcggcgacgt tcttcacgca cagctccact cccatccggg
    12301 ccgctacgac gagatcctga gccaccacgt cccccacctg ctcgccgcat tcggggagga
    12361 gccgccgact tggtggttca cccgccaccg ggagatggcc cggccggacg ccgaccagca
    12421 cctcgacctc accctgctcc tgtcgccgga ctcgtacgga gtcggcgcac agcaagcccg
    12481 cgcctgggcc gacaacctgc acacgatggg actcgcgtcc ggactcgccc tggccccgta
    12541 ccagccgcag gccggacgct tcggccacgg gccggccatg gacgccgcgc accaggtgtt
    12601 cgccgcggac tccgccgccg cccttgcgca gatccagctc gccgagcgca ccgatgcctt
    12661 cgcccgacag gccctcgccg ccgccagcgc gctgcacctc gtcactcccc tggcaccgaa
    12721 cgctgcggcg gccgaagagt ggctggtggg caacctcccc cagggcaccg gacgcttgga
    12781 ccggaccctg cgcagccagg tgctcgaact cactgggcca aacggcgcct ctgcgctcgc
    12841 gcccctcccc gggggccagc aggtcaccga agcgtggcga gcccgcgccg ccgccgtgga
    12901 cttctatcgg accgcattgg tcagtgaacg taatccgctc gacgtcgccc ggtcgctgct
    12961 gcaccagcac cacgtccgaa ctcttggcgt cgatccgcgc accgaggaga cgacgattcg
    13021 actcgtgcga acagccgccc tccagcaccg gatggcggac cgatgaccac gctggcaacc
    13081 accgccgcaa cagccttgga gcagtacaca gctgatctgg ctgagcctcc tcccccgccc
    13141 ccggaggagc cctgggcggt gcagtcgctc gccgacggcg ctgccggaat cagcctgctg
    13201 cacatcgaga tcgccagcag gtacggcggc tcctggcgtt ccgcgcaccg gtggatcacg
    13261 agtgcagcct ccggacccat cagcgcggcc gaccagacgg gcctgttcct cggcgccccg
    13321 gccgtcggct tcgtcctcac cgccgtccct cgggcctacc agcatctgta cgtctcggcc
    13381 cgcacgaccc ttcaccagca catcaccgac ctcgccaacc gccgcgtgga cgccgcgctc
    13441 gcccgcatcg acaggggaga cctgccgacc ttcgcggagt acgacctctt ctacggcctc
    13501 acagggatcg gcgcctacct cctgcgcacc gagcccgaag gcacagccct ggagaggatc
    13561 ttgcagtacc tcgtcgccct gacccggcca ctcgccgctg acaggcgcgg gctgcccggc
    13621 tggtgggtac gccatgaccc ggcgcgcggc gagtcgcccc acttcccggg cgggcacggc
    13681 aacttcggcg cagcccacgg cattactggc ccacttctcc tcctggccca ggccatgcgc
    13741 cgaggcatca ccgtccgtgg tcaccaggac gccatgttca ccatctgcgc ccacctcgac
    13801 gcctggtgcc agcacggcga ttacggcccc tggtggccag agcacatctc ccggcgcgac
    13861 cacgaccgcg gccaacctca tcacgacgcc cccgcccgcc cgagctggtg ctacggcaca
    13921 acgggcatcg cacgcgcagg gcaactcgca gggatcgccc tgcgctcacc cacactccag
    13981 aacttctacg aggacgccct gtaccggaca ttgtccgatc ccgcgcaact cgccctggtc
    14041 accgacagcg gtctctgcca tggatgggcg ggcatctacc agaccgctca ccgcgcagcc
    14101 gcagacgctc tcgacccgcg gcttcacgcc ctcccggaac gctttggtga cgccctcgcc
    14161 gcatccggcc ggtccagctc cctctcggat cccggcctga tcaacggcgc cgccggcacc
    14221 gcactcgccc tcaccacgct cgcctcgcag caggcgccga gcactggatg ggacacatgt
    14281 ctcttgatca actgatccag acaaccgagc cgagtccgac gcagcacgcc gtcctcgccg
    14341 tcctgaccgg cctgccgctc gccgacgcgg cgcagcagta ccggatagac cctgtggtcc
    14401 tctccgacgc ggtcgcggtc tacgaccagg ccggccgaga agccctggcc cgccacgcag
    14461 ccatcaccga ctggtggcag acgtacctcc acttcaccga ctggccgaac gccgacacca
    14521 ccttcaccac gcacgtcctg cccatcctgc gcgaggcgga agccgcccgc gcgatcgacg
    14581 gctggtggta caccagaaag cacccctgct ggcggctgcg cctccgggtc cagcctgcgg
    14641 gcggcgccaa gctgacgatc ggggacggct tcgaccgcct cgtctccgac ggacaccttc
    14701 agcgctggtg gcccggcatc tacgaaccgg agactccagc gttcggcggg aagaccagca
    14761 tgacggccgc gcacgccctg ttcgtcaccg atagccgaga gatccagctg ttgcgccagc
    14821 gcgacgatct caccgtcggg cccagggaac tgtccgtcct cctgtgcacg atcatgatgc
    14881 gcgccgcccg actggagtgg tacgagcagg gcgatgtctg ggaccgcgtc attacgacgg
    14941 agcaccgctc ggccgtcagc gacgttccgc cggaacagct cgacgcccga gtccaggaga
    15001 tccgtcctct gcttctcgcc gacagtgacg tcctgctgcg ccccgggggc ccactggaac
    15061 ctgtcgccga gtgggtcgcc gcatttcaca acgccggcca agccctcgcc gacggcgtcc
    15121 gagacggaac actcgaccgt gggctgcgac aggtgctcag ctaccacgtg atctttcact
    15181 ggaatcgact cgggctatca atgcgagggc agagcattct ggcttgggca gccagagcag
    15241 cgattctgtg cggcaatggg cacaaggagg gctagcacgg cacctccggc tcagcaacgt
    15301 ctattcgtcg acctgctcgg ttgccggggc tggagccaat ggtaggaagt actcctcggc
    15361 gagtttcgcc aggtgcagcg ggagcggccg ggcaagcggg tggtactcgt cgtggaagcg
    15421 cagctggtgg acggctgccg caattactgc gggtcgttct ggcgtcgcgc cggggcttcc
    15481 ccccgcagcc agagctgcct ccgacagaca tcccagcacg gtgagttcca atgcctgtgg
    15541 attccaggcc gtagccgcag ggccgtgggg ccagtccttg tcgggtacca gtttgcgtag
    15601 gtcgcgccgc accgtgcctg ccgtcggcgg tttaccgacg gtgctgacga acacacggtt
    15661 gtccgggctc gcctcgcggg cggcccagag gccagcggag aaccctggcg gctcctcgtc
    15721 ggtctcgccg ggcgcatacc actcgggcgt ctcgccgcga ctgttggcgt cccgaatcaa
    15781 caccgctcgc aagccgcctc catagagcgc gagccgcgtc agctgttccc cgtgcaaagt
    15841 caccatgtcc ctgaccagtt gtccgttgtt caggccgggc cataccccgc gtaggttgcc
    15901 gctgtttacc aggagcaggg tcggtcgatc gcgtacttgg tagagcagtg acctgacctg
    15961 gcgctcgacc tcgtcacgcc gctcatcctg ggtggagaag gcccgggctg atcggatctg
    16021 cgtcgggtgg tccgacgtga actcgtcggc agcgagggca agcaatagtt gggcgtatgg
    16081 gagccacttt ttgcgggtgt cgtcccagcc acacaccgga tgtacaggat cgcgtggccg
    16141 gatgcggaga gcaaccaagc gctgtcccgc ctgtcgggtc ggaccgtctg cctggcaccg
    16201 gacgtaccag agcgccaggt actgaaggcc atccgccagc ttgtcgtcca gccgttggtc
    16261 cggcgggacc acagcaccga gttggcgcat cccgtcggct acggcggact ttgcacgatg
    16321 ggccacggcc ccgtcagagt cttccggaac cacgatgaac tggctgactc gacgggccac
    16381 ggcgcaaccg agccggagtg cagacttggg atcggagtcc cggactggga agcgctcggg
    16441 accgagcgtc tccacgatca ccagcccttc cgaggccggt ggggggacaa agtggccagt
    16501 cgtccgtgca gcgcgctccc gtacagcctg agcgagcgcc tgcgctcgtt tgtggccgga
    16561 cttccggatg acctcgagtg gggcgcccag ggtcccgagc ggacgggtac gcaacctgac
    16621 tcgcagttcg ccgtcctgcc actcatgttc accatccact ccgcaggatc cggcagagag
    16681 gcccagccac tcacgaagcg ccgcgaccaa agcgtcccgg gtctcctcgg tctgccagag
    16741 tacgtccacc aacagcggac gcccgtcgag ggtcgcgcgc accgcgtccc ggcgggcttg
    16801 gattcggttc cgggcccgct tctcctgctc cgcctggtct ttcgtcgggg aggtgggcag
    16861 caggacgggc ttggacttcc ggtgcacgcg ttcaagctca ggtacccggc gcaggaaggg
    16921 gccgatgcct tcctcgaccc agtggtcgag cagcgagcgt tccaacggca tgagcccggc
    16981 gccgacacca tgccgcccca tcgcggtgct gtgcaggatg ccagccgcaa ccccgttctg
    17041 tccttcgatc cacccgaccg gttcggcaac cagatcagac ggcttggggt aggcgcgcgt
    17101 cacgtccagt tcgggcagca ggccgaccag actctgccga ctccaggcga gcatcccgag
    17161 gctgcggtcg taggcaaggg aattggctgt gagccgtcgg cgcgggccgt ggacacctgg
    17221 ccacggcagc ggcgcgtcga gcagtacggt cgcaccatgc ccttccggca gccatacggg
    17281 cgatcctgtg gcccagcgac ggatcccgta tgagacatgc acacggaacc gtggggcgaa
    17341 gggcaccgtc tgaacggtga cggtcaccag tcctgagtag aaccatgtgt gttttccctt
    17401 cgcgtacgac cgtggtggcc agctgaccag ctcaactcct tggtcgcggg tgaccagccg
    17461 gaaggacagg tcgacgccgt tgaggcgaag tggggaggag gcaagcctgg caccgatccg
    17521 ctcgggcagc agttgataga gcctgcggtc ggggtgggcg gtgccgcccg gagagtgatc
    17581 cgcagccgtg aggtccaccg actcagtgcg ccactgcggg gtgtagtcgt cgatcagtgc
    17641 aagggcccgg tcgagggctg cccggtggtt ggccatgcgc tcaggctcgg gatcggtgcc
    17701 gggcggcagg gtcatcaccc aggaggccag cagcggggag atcagctccg cgggcatctc
    17761 ctcggacgca tagaaccacg ggacctcggc gttgctgccg gcccccctgc ccgtggccac
    17821 caggcccgga gcggtggctc ggagtaggtc gttgagcttg ctgatcggca aggccgtcgg
    17881 ctgttcccgg cggcgccatc gccgccggta gaggtccatg aactcggccc gccactcttc
    17941 gggaaagctg atgacccggt actgctcagc ccagggttcc ctgtccatat ccggttcata
    18001 ggctgtggta ctgatcaggt gatacacgcg gtgttccctt cattggggga tggatggagg
    18061 cagcggtcga gggctgtcca catcgggcgg tagagcgccc ggacgatgtg acgatcgtcg
    18121 gcaggcacgt cggtcccggg ggtgaagtag ggctcaagga cggagtggat gctgtgcagg
    18181 aggctgctct tgggagtgtc cggttcctgg gacgcccctc cagcggccag atggggggag
    18241 aatgtggcgt cgacaaaggc gaccctggta ggcaccgcac cacgcacgga acggccgatc
    18301 acctgccaga tcagtacgag caggtcccag gtgatcgctt cccggtcatc tccgagggag
    18361 ctccatgcca tgctccgggc gagcacccgg taccactgag atcgagcgag atccctgacc
    18421 ttgcgggcac cgagaccgag gctgggctcg cttcgtaccc attcgtcgaa cgccccgccc
    18481 ctcatggccc gcacaatcca gtcgttgatc gcgtgtaccg cgaggccgag gtcgtcgggg
    18541 cgcgggttgg gtcgggcgag gaagtagatc gacccgatcg cagcgtgatc gcggtctagg
    18601 tcgaggatgt tgtgtccgcg ctcgacagct agtagcggcg ccaccaggat ctcggcgcgg
    18661 gtactggcca gcgtctcgac gtcgccacgg cgcaggatgg gcgcgtggtg ctcgtcgccc
    18721 tcccccaaaa cgccggcctc gggatcgtcg tccgacacca gccggcggac cctgcacttc
    18781 caccgcctat tgagggtgtg cagggtgtcc gccacgactt tggattcctc ataactgccg
    18841 acgagcagca ggatgtggcg gcgactctcc ggaaggcgct gtaactcctc ccggagacgg
    18901 ctgattccgg cgtcttcgtc gccgagggcg acggccatcc ggcgcaggat ctcctgccgt
    18961 tgatcgagtg gctcgccgga gagtcgctgc gcgtcgtact gtccatcgca ggtgcagccc
    19021 gcgcggcatc cgcagacgct gcgaatgaac tcgaagcgga actcactctg ttcggcgatc
    19081 cggtccaggt cctccgggcc tggctcgatg atcacgccta tttccaccgg aatgtgatag
    19141 cggctggact tgcctgccca actgctaccc gacatcaaca ggacgttggt accagggcga
    19201 ccatccaccg tcggcaggtc gggcatctcc cgaagtagtt cccggccgac cccgctgcac
    19261 cggaagaacc tgagttcccc ggtgcgcact ccaccgtgat ccgggctgtc catcagaaac
    19321 tggaagccga tcacattgcc catcggcgcc tcgggcacca tgggtccgta gtcgagcggc
    19381 ctgcggtaca tctcgttgaa gcccaggttg agtgctgacg cgacacgcgg ccacatggcg
    19441 ttgatcaggg caagtctggg ctccagggcg ctgaggagca tggtgaactc gaagcgggtc
    19501 acgagcagct tgagccagtc gtcagagttc tccggaaggg gttccttctt cagccgcctc
    19561 gccctcttgc ggctctttcc aggaggctgc ggcgcccggg gccgctcggc ggccgcgagg
    19621 tggcgcagct cctcgtactg ctcagaggct tcggccgtgg gctccagcag cgggtccagg
    19681 gcgaaaaggc ggcataccat ctcctccagc cgctcgcggg ttgtttcgcg ccggttggtg
    19741 tgcaggagtt cgcccagcaa ggcggtgagt tccacgccgt cctcggtgta tcgctgccgg
    19801 tcgccgaacg gattctcccg gaaggcgtcg aggatctcgg tgagtcgaag ccgcggagcc
    19861 cggtgccgat gcccgaccgc aggtcccaat gcctcggccg acgtcccctc acgatcttcc
    19921 gggagcggat accgctcctc caccaggcgg agttggagcg tccacgcgct gaagtaccca
    19981 gttctgaccc agttccgcag ttccacatcg cggacgagca tggccaccag gcggtcggcg
    20041 gcggtctgcg tggtgttgac ggccgccgac cagttctcca cgtcgcggtc ggacaactgg
    20101 atcccgccgg caccggccaa ctcacggata cggtgctggt tgacatcgtg caggaaggac
    20161 cgtgtgtcgg agccgccgcc gatcagcggg atggccggcg cgaacatccg atccaactgc
    20221 atctggactc ggtccgcctc atcgatgatc accaggtcac tgcgccgaca ggcgagttcg
    20281 aggtaccgga cgcgttccgg gttctgtggg tgcggcacct tggaatccac caggctgggc
    20341 ggtgtggcaa cccatagggc cgcgccgacc agctctcggg ctccgtggtg gcggggacag
    20401 gcggaccaga aaggacaggc caactgccgc cgttcccaaa ggtcaccggc gggatcgcgg
    20461 cggctgggct tctgcaatcg ggcgcaaggc gcctcgccga atcccagcag atcgtcggcg
    20521 agctgcccct ctgcgtatcg gagtgcattc agagcgcagg acgtgctcag gtatgcgaac
    20581 gccggatcgt cgtgcgcgag caggttgcgt ctgccacggc cagccaaccg ccggtgcagt
    20641 cgctcggcgt gccgctggcg acccgaagca ccaagaaccg gcgcggcaga tcggggcacg
    20701 tatgtgttgt accgctccac catcttgagc tgttccgcga cgtccccgac gacgatggtc
    20761 gcccgcatgc cctgccgggc catgtgcacc gccagcacgt ctcgcagggt gctcttaccg
    20821 gcgccgacga tgcccagcag gtgctggatc cgtcgcacct caaagcggtc cgcgcaccgg
    20881 aacccgtccg cctggcgggt gaagaggtgg accgccccaa gccgccctgc ccagttctcg
    20941 gacttcacgg aatccatgta cgccgctgtc tccagcaggt cgccccacag gaaggacagt
    21001 ggcttaccgc cgttctccgg cagtgtcgcg aaatcatgtt cgaccggtga gggaagggct
    21061 gactcgggca gctgaacggt ggcctgatgc cgtccgatcg ggaaggtgtg ccctccggcc
    21121 gccgcgatca ccatgggccg tccggcgaaa gcaggtgcct cgcgcagcag ccgttcgtag
    21181 gcgtcccagc ggtccggcgc caccgatagc gaacgccgac ggacggctgg aagactcagg
    21241 tcggcgacct catagcctct gagctgccgg tcgagcagct ggtaatcctg gagtgcctcg
    21301 gtccacgccc tacgccgacc ccaggtccac accgtgtgcc gggctgtgcg gagagtccgc
    21361 tcgccaacag catcgacggc tcgccaagcc cgtgcgaacg ggtacccgct gaacagtgtc
    21421 caggcgtcct ctgccggagc ttctgccgcg aatgtctctt ggaggaggag ccccacctcg
    21481 atctcgcaca aggagacgag ccgggcagtc ttcatcttcg gggcggcatc cgacagtggg
    21541 acgaccacct cgcgcaggga ctgggaagta ctacgcacgg ttcctcctcg atcgatgggc
    21601 tggtcccggt gttgtgaaat cgctcgcggc cacgaggcgc acctgagctc ccaccggtag
    21661 ggcaaggtcg aagcgccggc gacatccggg gcgccctgcc atggcgtccg gcatcacgat
    21721 gtccagggga ccgtcgagca gcgtggcgac ctccgccgcc cgcagagcgg ccaggcccgg
    21781 ttgttctcgg tcatagacct ggaagacccg gagagttccg tccgggctgg tgacgcgatg
    21841 gacgcccaga cccagtggga gcagctggac ctgatctgtg agccgggagc ggactgtctg
    21901 ctcggtgcga ccgggaagtg ccaggaaaag ccggagcgcg aagggaagag caagggccga
    21961 ctgggacccc tgggacgttt cgagttcacg gtctccggat gaacagccac cctcacacca
    22021 agggcgcccg gccgtgacgt acttggcgag cagcccacaa tcgcgacagc agtgcagcag
    22081 cccggcgtcc gggaagcggt cgggcacagg accgtagagt cccttgacca gattccagac
    22141 ttgagccacg gccggctgca tcagctgcat cggatcagga cggagcatga ccggccggtc
    22201 gatgaggaag tctcggcacg ccgcgaatcg ctccacggtg ccgcaggcag cggcgagttc
    22261 ggcgagcagt gtttcggctt cccgctccgg cacaccgtac gggccgaggg aggccagttc
    22321 gacgcaggtc cgcgtaggct cacccgcctc ggggtgaatc aggcgggtgc caacggtcag
    22381 gaattcgtcc ggtaaccctg gcacccattc ttccggccct cgttctcgac accaacgcat
    22441 caggtccggt actccggccg gaaccggatg gctgcgggtc attcccgaca acaccacttg
    22501 gtccaagaca agttgaactc ctggtgggta agggagccgg agtgccgcag accggttgat
    22561 cgaggtcagt tcgagcacgc cgcgggccac tgcggccagc agagcgatgg cctgtccgtc
    22621 ctcggtcact ggccctcctc tgagcccact tgctgcgact gccgcacaga gcaccacctc
    22681 gccacctcgc agtgggcaca ctccgggccg ggcactgcct cgaacagcgt ctccgtatgc
    22741 cagccttcga cctgttcgcg tagcaccgct tcggcgacgg caagggtcgc gggtgcgaag
    22801 ggatcgatgg tgcgcagatc ggctccggcg gggcgcagca gctccagttc gacccgcccc
    22861 cggacctgcg ggccggaaag tacgccgctg ccaatgatct tcacggccag ggccagctga
    22921 gggtaggcag ccaacaggtc gcggcgaggc cggtcactgg cagaagtttt agtctcccgc
    22981 cagacccatg aaccctcgct tctgtagagc aggtcgggtt ccgccaggac gagcaggtcg
    23041 gctgcggtgt cgtcgaaggc catcctgggc tcgatccgga tctccgactc cggttcggcc
    23101 gtgtgcagcg ggcagacctc agcatggtgc cgcagcagat cggcaccaag ctgccgctcc
    23161 tcatcgggga gccggtaccc ctcgggcacc cagtccctcg ggatctcagg tgtgcagggc
    23221 gtgcgcgact gccgttcgtg ccgctcggcg aggaaggcgt gcaacgcccg cccacgctcg
    23281 gcagcggtgc cccgctccac ggtgtcatca gccgggagcc gcaggccgcg caggtagccg
    23341 cgggccgggc aactctggtg gccacgcccg gtggtcgagg accaactgcg ccgcggctga
    23401 cttcgatcgg ccgtccccag taagcccgcg gtcttcggaa gcgtcgggca cactggcgcg
    23461 atagcacacg agacgcaggc ggtaccgggg cggtattcct ggctgccgag cagagcgcga
    23521 acagcgggcg ccccgtccct ccggtacaag gtcagtgcct cggcccggct gccttcgaag
    23581 atcggagccg tgcgaccgtc ggacagggcg aactgaacga ccctgacttc ttccagtcgt
    23641 ggatcagggt tcccttcggc cgctacaagg gcggctatcg cgcgctctgt gtcgctgcgc
    23701 gtacggaggc gcttgaccac cggcagtcgc agctctcgcc ggcgaccgtc gggggattcc
    23761 aaacagcggc cccaagccgt gatccggtat tccacggcgg cctgaccgtc gccggccgct
    23821 cgctgatgct tgtagaccca ggggttggga gcgaggtgca gggccgaatt cggtaccgag
    23881 tcggtgggaa aagccttccg gtacatcagt agcgcatgct cggtccactg gcgcacccca
    23941 tcgtgcagcg gacgctgtcg acctccgctc ggcgggttcg gcgacgattc gtccgctggc
    24001 cgatcgagct cgtcggccgc agccatgaac gggccgttgg ggaacggatc caacacctca
    24061 ggtttccagg cgggccgtac acgaggccgc atcccgcgtg ccttcagcac gtcggacgcc
    24121 gggcaccggt accgctccgg gccgaacatg cttagccgca gggtgacggt ggtggatccc
    24181 ccgatcagtc cgtcgggtgg ccaggtctct gtcataatcc tctcgtttct ctaggccccg
    24241 gaacaggttg tcgaacctgc tgggtaatcc tcttttgact acggagcgaa tgaagtgctt
    24301 cccgggactt ttctcgacgg gcgttaccgg gtgctgcgga agctcggcca cggcggcgag
    24361 ggtgagctct tcgtcgcccg ggacgagttg gaccgttgcg aagtggcggt taaagctcaa
    24421 ttcccccgca ccttcgaatc aacgaagacc tatgcctctg ccgcctttgc tttggaagac
    24481 gagcttgaac gactcacatt catgcggcat gtaccaggaa ttcctgaggt actgggagac
    24541 ggttattacg ggcggcaccg gggccgatac attgtgatgg aactggtcca aggcgatacg
    24601 attgcgtcct ggatcagcga ccaccatcca gttccagcgg ctgcggcagt ctcagtcgtc
    24661 gcgcagctct gcgatattct gcacggcgta catagggagg gctacgtaca tcgggatgtc
    24721 tccgcgaaga atgccatgat gcagcccagt gggaaggtca gactgctaga cgtaggcatt
    24781 tccgggccga tcggggaaat caactcagat cctcgcggca ctccgggtta tgcacctccg
    24841 gagcagtacg acaataaagc actactgact ccgcaggtcg atgtcttctc cctcggcacc
    24901 atgctgttcg ccatggtcgg cgccgagttg ccttacagcg gcctggaagg cccaccagat
    24961 gccaccaccc cagccttccc gaacgggttt cgtgcccata tgtccaatac gcttcagagc
    25021 ctcgcgctcg ccatggtctc catcgacccg ggtgaacgcc cggatctggc tgcgctgcgg
    25081 aactacctgc ggccaatgct gcccaccccc cgctgccccg cctccccgaa ggccacccgg
    25141 ccggacccga ccacccctta ccggcttggc ttgtcgttgc cgtaaccggg acggagccag
    25201 caccctgtcg aacggccgtc acgggaggca cctcatacgc tcgacagccg cgtccaggtc
    25261 gttctcaccc agttc
//
