LOCUS       NZ_LWLE01000004        18186 bp    DNA     linear   CON 27-MAR-2024
DEFINITION  Streptomyces sp. TSRI0281 scaffold12, whole genome shotgun sequence.
ACCESSION   NZ_LWLE01000004
VERSION     NZ_LWLE01000004.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. TSRI0281
  ORGANISM  Streptomyces sp. TSRI0281
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 350528)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 350528)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra,H. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-APR-2016) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2016
            Assembly Method                   :: CLC NGS Cell v. 8.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905125.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:37:03
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,600
            CDSs (total)                      :: 8,518
            Genes (coding)                    :: 8,175
            CDSs (with protein)               :: 8,175
            Genes (RNA)                       :: 82
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 76
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 345
            CDSs (without protein)            :: 343
            Pseudo Genes (ambiguous residues) :: 0 of 345
            Pseudo Genes (frameshifted)       :: 151 of 345
            Pseudo Genes (incomplete)         :: 273 of 345
            Pseudo Genes (internal stop)      :: 33 of 345
            Pseudo Genes (multiple problems)  :: 102 of 345
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:13:17
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 332342
            Orig. end                         :: 350528
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LWLE01000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..18186
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="amglyccycl"
                     /region_number="2"
                     /rules="(DOIS or ValA or salQ or strH or strK1 or strK2 or
                     NeoL or SpcFG or SpcDK_glyc)"
                     /tool="antismash"
     cand_cluster    1..18186
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /kind="single"
                     /product="amglyccycl"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..18186
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[10000:11128](+)"
                     /cutoff="20000"
                     /detection_rule="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /neighbourhood="10000"
                     /product="amglyccycl"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11128
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /neighbourhood="10000"
                     /product="amglyccycl"
                     /protocluster_number="1"
     gene            complement(1010..2071)
                     /locus_tag="A6A29_RS11420"
                     /old_locus_tag="A6A29_29765"
     CDS             complement(1010..2071)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="other (smcogs) SMCOG1092: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016828386.1"
                     /locus_tag="A6A29_RS11420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_29765"
                     /product="ArsO family NAD(P)H-dependent flavin-containing
                     monooxygenase"
                     /protein_id="WP_073719906.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 7e-15, bitscore:
                     49.2, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGVADVVLIGGGQAGLAAGYYLRRKKLDFVILDAQNEPGGAWRH
                     TWDSLRLFSPAAFSSLPGRLMPAQSGQEHPDAGHVVDYLADYEQRYDLPVHRPVRVASV
                     LRDGRRLRVETDAGVWSARAVVSATGTWWRPFLPAVPGREVFTGRQLHTTGYRSSADFA
                     GQRVAVVGGGNSGAQIAADLALADDVSLTWVTQRPPRFLADNIDGRALFDAATARRRAL
                     EDGMADSGGVASLGDIVAVAPVRAARDAGLLKAEPMFTRLTTDGIAWADGTHAEADAVI
                     WSTGFRPALSHLAPLGLRGSRGHIETAGTRAVQEPRLHLLGYGDWTGPASATLIGVGRP
                     AREATAEIAALLS"
     gene            complement(2068..2289)
                     /locus_tag="A6A29_RS11425"
     CDS             complement(2068..2289)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021464.4"
                     /locus_tag="A6A29_RS11425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF2180 family protein"
                     /protein_id="WP_073719907.1"
                     /transl_table=11
                     /translation="MHCLDCHATGTHSATVGICHGCGAGVCAGHTRIAARSVRRGPLPG
                     AFGEAPARRVLCPVCAAAESPAATALTP"
     gene            complement(2289..3416)
                     /gene="arsB"
                     /locus_tag="A6A29_RS11430"
                     /old_locus_tag="A6A29_29770"
     CDS             complement(2289..3416)
                     /GO_function="GO:0008490 - arsenite secondary active
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_process="GO:0046685 - response to arsenic-containing
                     substance [Evidence IEA]"
                     /codon_start=1
                     /gene="arsB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019548550.1"
                     /locus_tag="A6A29_RS11430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_29770"
                     /product="ACR3 family arsenite efflux transporter"
                     /protein_id="WP_073719908.1"
                     /transl_table=11
                     /translation="MTSTEPATASTDGPGPAVDDSIVKKLSTLDRYLAVWILLAMAVGL
                     GLGRLIPGMNDALAKIEIGGISLPIALGLLVMMYPVLAKVRYDRLDRVTGDKKLMVSSL
                     VINWIVGPAVMFALAWIFLPDLPEYRTGLIIVGLARCIAMVIIWNDLACGDREAAAVLV
                     ALNSVFQVFAFGVLGWFYLDLLPRWLNLGDGQGLDVSVWHIALNVIIFLGIPLLAGFLT
                     RRVGEKKMGREKYETRFLPKIGPWALYGLLFTIVILFALQGKTITSQPMDVVRIALPLL
                     VYFAIMFFGSFLLGKSLGLAYDRTSTLAFTAAGNNFELAIAVAIATFGVTSGQALSGVV
                     GPLIEVPVLIGLVYVALAWRKKFAPTALTTPGRDS"
     gene            complement(3413..3721)
                     /locus_tag="A6A29_RS11435"
                     /old_locus_tag="A6A29_29775"
     CDS             complement(3413..3721)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003975238.1"
                     /locus_tag="A6A29_RS11435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_29775"
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_073719909.1"
                     /transl_table=11
                     /translation="MMTSVDTDVIRVLGDPLRMQVVALLARETLCMSHLVEETGAKQTN
                     LSNHMKVLREAGLVETEPCGRFTYFKLRPEVLASVSTQFAELADSARTAVENKRACP"
     gene            3796..4428
                     /locus_tag="A6A29_RS11440"
                     /old_locus_tag="A6A29_29780"
     CDS             3796..4428
                     /EC_number="1.20.4.4"
                     /GO_function="GO:0030612 - arsenate reductase (thioredoxin)
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645475.1"
                     /locus_tag="A6A29_RS11440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_29780"
                     /product="arsenate reductase ArsC"
                     /protein_id="WP_073719910.1"
                     /transl_table=11
                     /translation="MCVPPPPAWPDERLGAGAARLASRHRGHFSVETVQQLLTDSYRRL
                     AENARVRTHLVVRAERLTAERLDALAHTGAPGKGVVRVLFVCGHNAGRSQMAAALLAHR
                     AGERVIVSSAGTDPAAEVEPHVAQVLLESGLSIADAYPKPLTSEVVGAADYVITMGCGD
                     ACPVVPGRHYLDWSVADPDGAPIGVVRTIRDDIDARITRLLANLPDT"
     gene            4477..4890
                     /locus_tag="A6A29_RS11445"
                     /old_locus_tag="A6A29_29785"
     CDS             4477..4890
                     /EC_number="1.20.4.4"
                     /GO_function="GO:0030612 - arsenate reductase (thioredoxin)
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019548548.1"
                     /locus_tag="A6A29_RS11445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_29785"
                     /product="arsenate reductase ArsC"
                     /protein_id="WP_073719911.1"
                     /transl_table=11
                     /translation="MSDKPSVLFVCVHNAGRSQMAAAWLTHLAGDRVEVRSAGSNPGTA
                     VNPAAVAAMAEVGIDISAQTPKILTIDAVKESDVCITMGCGDTCPVFPGKRYLDWQLED
                     PAGQGVEAVRPIRDEIKNLVEGLIKEIAPEKTA"
     gene            4887..5861
                     /gene="trxB"
                     /locus_tag="A6A29_RS11450"
                     /old_locus_tag="A6A29_29790"
     CDS             4887..5861
                     /EC_number="1.8.1.9"
                     /GO_function="GO:0004791 - thioredoxin-disulfide reductase
                     (NADP) activity [Evidence IEA]"
                     /codon_start=1
                     /gene="trxB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1176: alkyl hydroperoxide reductase subunit"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007445798.1"
                     /locus_tag="A6A29_RS11450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_29790"
                     /product="thioredoxin-disulfide reductase"
                     /protein_id="WP_073719912.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 3e-45, bitscore:
                     148.9, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEIREVVIVGSGPAGYTAALYTARARLKPLLFSSSIFVGGSLTT
                     TTEVENFPGFPEGVDGPVLMENMRAQAMRFGAEMIDDDIVSVDLAGDIKLLTDSEGTVH
                     RAKTVIVATGSGYRKLGLPKEDELSGRGVSWCATCDGFFFKGRDIVVVGGGDTAMEEAT
                     FLTRFAKSVTVVHRRSTLRASKVMQDRAFSDDRISFALDSEIAEIKETGGMLAGVVLRD
                     VLTGATRDLDVTGLFIATGHDPRTELFKGQLDLDTKGYIQVASPSTRTSAPGVFASGDV
                     VDHPYRQAITAAGTGAASALDAERYLAARNTAQAQQEPATIPA"
     gene            complement(<6494..6754)
                     /locus_tag="A6A29_RS11455"
                     /old_locus_tag="A6A29_29795"
                     /pseudo=""
     CDS             complement(<6494..6754)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014143667.1"
                     /locus_tag="A6A29_RS11455"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_29795"
                     /product="helix-turn-helix domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MAEPVRARRLTDQEGQRLQQIVRRGRHESVRVRRALIIMASASGT
                     PVTAIARLVAAHEDTVRDVIHAFNEKGLATLDPQWAGGRPRR"
     misc_feature    complement(7777..7788)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 16.94"
                     /tool="antismash"
     misc_feature    7920..7934
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.08"
                     /tool="antismash"
     gene            8242..8952
                     /gene="pgl"
                     /locus_tag="A6A29_RS11470"
                     /old_locus_tag="A6A29_29800"
     CDS             8242..8952
                     /EC_number="3.1.1.31"
                     /GO_function="GO:0017057 - 6-phosphogluconolactonase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006098 - pentose-phosphate shunt [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pgl"
                     /inference="COORDINATES: protein motif:HMM:TIGR01198.1"
                     /locus_tag="A6A29_RS11470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_29800"
                     /product="6-phosphogluconolactonase"
                     /protein_id="WP_073719913.1"
                     /transl_table=11
                     /translation="MRSAIKSASYPNRESLAEAAARLLVEKIALCTAEEGRCLVALSGG
                     STPAATYRLLAGAGLDWGAVHIVQTDERVTGVRSETSAAVIEDNLVRPARIPASRWHPM
                     PGITGDDLARSAADYARTLGGLGGDGTPDIVLLGLGEDGHTASLFEGDTAAETAERVAV
                     TMPYQGTVRLTLGAGLLAGARTRIVLAAGKAKAQAVSRLLNGDVPAGDPAARILGEDGM
                     LFVDHEALAYSEAL"
     gene            8958..10004
                     /locus_tag="A6A29_RS11475"
                     /old_locus_tag="A6A29_29805"
     CDS             8958..10004
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1108: ROK family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003952907.1"
                     /locus_tag="A6A29_RS11475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_29805"
                     /product="ROK family protein"
                     /protein_id="WP_241838421.1"
                     /transl_table=11
                     /translation="MLVFDLGGSWWRVGLFTDERQVHLIRREPAVNRSSADRPVPVLQQ
                     ELVDFVLRHTRAYLRERALLRVGISLGAAMNGQTGRVLASAPMWGPELAPFDLLAVLRD
                     ELPGLAWGVLNDVSALAVALRARMPAGGRKAAAVTVSSGIAYRTIDLRTGHIPLDPEHG
                     LQGEIGHLPVDFVMEGRRVEAQCECGASGHLAAFSSGRGIEELLGVLPEAAWLRAGSDA
                     PAGPVAAFGVAVRRGDPRALRLLDAFTRPLSRILLAQTTLDPEVGHTVLSGGVVDGLEG
                     HYLSSLLRNLMADGLYGISHADPHYFRRRFAVGSPDGLDPLRGAGLHVAGLSSPPAQER
                     LDRQGLTS"
     gene            10001..11128
                     /locus_tag="A6A29_RS11480"
                     /old_locus_tag="A6A29_29810"
     CDS             10001..11128
                     /EC_number="4.2.3.-"
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     amglyccycl: salQ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DHQ_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1183: 3-dehydroquinate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003952908.1"
                     /locus_tag="A6A29_RS11480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_29810"
                     /product="sedoheptulose 7-phosphate cyclase"
                     /protein_id="WP_073719915.1"
                     /sec_met_domain="salQ (E-value: 1.5e-159, bitscore: 525.0,
                     seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="DHQ_synthase (E-value: 6.7e-67, bitscore:
                     219.6, seeds: 76, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSWTVRATQEVSYEVRQTRGVLGLDNPDLADAAGLEAGARRLVV
                     VDREVCRIYGAGIRAYFRHRDVDPVLLVLPADESNKTAASVFKVADAADHVGLNRRSDP
                     IVAIGGGVLTDVVGLAASLYRRGTPYVRVPTTLIGLVDAAVGVKTAVNYHSHKNRLGTY
                     FPAAVTLLDQGFLQTLPVRHIVNGLAEIIKMAVVRDAGLFDLLDDNAERLIEQMAQGDL
                     GRRVIESAVAGMLGELTPNLWEHDLKRLVDFGHTFSPSIELAVDPPLLHGEAVAIDMAL
                     SCLIAQERGLLSSAETQRSLGLMRSVGLPLSHPRVTPEALIDGLAEATRHRDGNQHVPL
                     PRGLGRTVFVEDIKPGEIRRAQRRSFELTGMWEAA"
     gene            11344..12237
                     /locus_tag="A6A29_RS11485"
                     /old_locus_tag="A6A29_29815"
     CDS             11344..12237
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A6A29_RS11485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A6A29_29815"
                     /product="dehydrogenase"
                     /protein_id="WP_107468187.1"
                     /transl_table=11
                     /translation="MIFNPVDPEAQDRVLGHSYDGVFQHTVLVDADSPVLFDADPLLIA
                     DLAPLVEPLAAVLYGWELVERDARPATAAVWGGGSTAVLTALVGELRGIRTHLVHRRAG
                     RLSFLTGQGIFGATTLHTGASGLRGIDAAFICLPREAAPGALSEVVSSLAPGGVVDLLG
                     GFAPGDVHGQIPGVDLGAVRRANVCGQPRPGATTRARTGDGAAIGLTGHRGTAPHHLAE
                     AQRLLRAHPDVFGALVTHVLSLEAAAAELQAVAAGSGPSVGPPERIKMVIDLCMPGRSH
                     RPADLTTTVGELKVTG"
     gene            12234..13292
                     /locus_tag="A6A29_RS11490"
                     /old_locus_tag="A6A29_29820"
     CDS             12234..13292
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019845.4"
                     /locus_tag="A6A29_RS11490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_29820"
                     /product="alcohol dehydrogenase catalytic domain-containing
                     protein"
                     /protein_id="WP_073719916.1"
                     /sec_met_domain="ADH_N (E-value: 3.4e-08, bitscore: 27.6,
                     seeds: 66, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSAGTAYQRLDHHHGRVTVTEAVVSDPAGRAMVVIAPQRIGVCR
                     SDLRELRSDRHQRRDFGHEIVADVVAATKGVAVSVGQRVVLDPHPQLHTRTSGFGQLVE
                     LSGTPDLLRDALVPVPRTMGVDRAVFTEPLACACHCIERLHTVTDELGMDRQGPVAVVG
                     AGMAGALIAAGLHASHVPVTVVNRGHERLDFLRRREFLPNPVLGGPDGSPLFSRTVLAT
                     AYAEPAQIRQALDLLLPGGLLLLFAGTRPGMELAGVDIDDLRRRERLAHVRVDGRPLAI
                     AGTHGALRTDFEHALQLLNRAANGEWRLGPAVERLVTRRMTLAQAARLLPEHADRGFLG
                     KPVVVPTPRRRP"
     gene            13289..14404
                     /locus_tag="A6A29_RS11495"
                     /old_locus_tag="A6A29_29825"
     CDS             13289..14404
                     /EC_number="2.6.1.-"
                     /GO_function="GO:0008483 - transaminase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_5 (33-164). E-value: 2.6e-10.
                     Score: 31.6. Matches aSDomain:
                     nrpspksdomains_A6A29_RS11495_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003952911.1"
                     /locus_tag="A6A29_RS11495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_29825"
                     /product="DegT/DnrJ/EryC1/StrS family aminotransferase"
                     /protein_id="WP_073719917.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 2.7e-119,
                     bitscore: 392.8, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 3.2e-08, bitscore:
                     27.0, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.4e-06, bitscore:
                     21.9, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVTKYNHRSQFEDLDALTHQIRATLESGDYILSPAVEQFEERLA
                     AHTGVAHAVGVNSGTDAIVLALRALGIGPGDEVITVANTFHASVLAITSVGARPVLVDC
                     TPDSYLMDLDQVDAAVTPRTRALLAVHLFGQALDMDRIAAIADRHSLAIVEDCAQAIGA
                     RWAGRRVGSFGQAGCFSFHPSKNLAAAGDGGALVTDDAAIARQVRTLRSLGQHQQNDHV
                     ERGYNSKLDAIQALVLNHKLDQVDKWNSRRSDIAGEYARALTGAELTPTPPAGERHVFH
                     LYQVTLAHRDHVLAELTRHGVEAVVRYPVPVHRQRAFADLHLPARFPQAQAQAENTLCL
                     PIRPDLTDREVDYVVRTLLKAVAPSRRNAAG"
     aSDomain        13388..13780
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A6A29_RS11495_Aminotran_5.1"
                     /evalue="2.60E-10"
                     /label="A6A29_RS11495_Aminotran_5.1"
                     /locus_tag="A6A29_RS11495"
                     /protein_end="164"
                     /protein_start="33"
                     /score="31.6"
                     /tool="antismash"
                     /translation="SPAVEQFEERLAAHTGVAHAVGVNSGTDAIVLALRALGIGPGDEV
                     ITVANTFHASVLAITSVGARPVLVDCTPDSYLMDLDQVDAAVTPRTRALLAVHLFGQAL
                     DMDRIAAIADRHSLAIVEDCAQAIGAR"
     gene            14429..15082
                     /locus_tag="A6A29_RS11500"
                     /old_locus_tag="A6A29_29830"
     CDS             14429..15082
                     /EC_number="5.1.3.1"
                     /GO_function="GO:0004750 - D-ribulose-phosphate 3-epimerase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003952912.1"
                     /locus_tag="A6A29_RS11500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_29830"
                     /product="ribulose-phosphate 3-epimerase"
                     /protein_id="WP_073719918.1"
                     /transl_table=11
                     /translation="MTTIAPALLGADPLALADAITEVERAEVDLIHLDVMDGHFVHDIS
                     FGLNTVRAIRKRTALPLDVHMQVQRPEQYLDELAASGVDTVSVHVESTLHLSAVLRRLE
                     TADIKRGVVINPATPLNTLDEVLDRIDQVVVMTCNPGTSDFQAQMVDKIRRLRALLEER
                     RIDHVRVVADGGINASRARVLAEAGADVLVAASAVFSSTHGDVAAGVAALRKAM"
     gene            15096..15776
                     /locus_tag="A6A29_RS11505"
                     /old_locus_tag="A6A29_29835"
     CDS             15096..15776
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024811.4"
                     /locus_tag="A6A29_RS11505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_29835"
                     /product="HAD-IA family hydrolase"
                     /protein_id="WP_073719919.1"
                     /sec_met_domain="HAD_2 (E-value: 4.2e-22, bitscore: 73.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLSAVAVLFDMDGVLVDSSGCISRAWFEWAGRHGLDAQGTLALG
                     HGLTTLDHIRAAAPALATEKEAALIDELEDRHVAAVIAQPGAAAATSSLTRADVPWGVV
                     TSCSREAATARLATAGLPLPSVLITADDVTRGKPAPDGYLTGISRVRAEPHRTVVFEDA
                     PSGITAAQAAGAHVIALSTTHAASQLLAVDSIVPDLSFVRFQREPHTTEVAIEILAARA
                     AQTR"
     gene            15998..17110
                     /locus_tag="A6A29_RS11510"
                     /old_locus_tag="A6A29_29840"
     CDS             15998..17110
                     /EC_number="6.3.2.2"
                     /GO_function="GO:0004357 - glutamate-cysteine ligase
                     activity [Evidence IEA]"
                     /GO_process="GO:0042398 - cellular modified amino acid
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1165: carboxylate-amine ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF010041.0"
                     /locus_tag="A6A29_RS11510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A29_29840"
                     /product="glutamate--cysteine ligase"
                     /protein_id="WP_073719920.1"
                     /transl_table=11
                     /translation="MTQPLTVGVEEEFFIVDSATRNLLPQSGQIITSALAQVDEQTPSR
                     FCEEFRPCMVESRSGICRTLDELRADVITSRSTLIRAAEEAGGRIAAAGTYPLADWRTQ
                     EFNTKPQYQRTVETYRLLADELLICGCHVHVGVADRDTAVEVMNRVRPWLPVLSALAAS
                     SPFWMGADTGYSSYRSMVWERWPTSGMPPTFRSYDEYQNSVRLSVESGISPVAGDIFWD
                     VRPGTQYQTVEFRIADSCATADEVILQAGLCRALVHTTLTEIEKGDTPADIRSELLRAA
                     KWRSTRFGLTDRLLDPFTAALVPAHEMVDRLCEHVRPSLEGTGDWTVASGITERIKRQG
                     TSAERQRAVFERRKSLEDIVDHQVRDTASW"
     gene            17314..>17910
                     /locus_tag="A6A29_RS11515"
                     /old_locus_tag="A6A29_29845"
                     /pseudo=""
     CDS             17314..>17910
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003969235.1"
                     /locus_tag="A6A29_RS11515"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="A6A29_29845"
                     /product="helix-turn-helix domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MAERVRVREMMTTRVGGCCGSSAAVRGRWWPGAGPGWSCCPRRAC
                     PWRRSPR"
ORIGIN
        1 cgccctcgcc cctcgccacg gcttcgcccg caccctggtg ctggagtccg ccgaggctcc
       61 gggcggggcg tggccgcgct actacggcag cctcaccctg ttctccccgg cccggtactc
      121 ctccctgccc ggcctgccct tccccggaga tccggtccgg tacccgacgc gggatgaggt
      181 ggccgactac ctgcgcgagt acgcccgtcg cctgcccgcg gacatccgca cctcgacccc
      241 ggccgcctcc gtctcccggc gggacggcgc ctgggaggta cgggccaccg acgacgagga
      301 gttcagggcg cgggcggtcg tcgccgccat gggcgactac ggctcgccgt acgtgccgca
      361 actgcccggc cgggcggagt tcggggggcg ggtgctgcac gccgccgacc accgcagccc
      421 ggaggggttc accgggcggc gggtcgtggt ggtgggcggc gggaactccg cgatccagat
      481 cgccgcagaa ctcggggccc ttgccgaggt gagcgtggcg gtgcgccggc cggtcggctg
      541 gatgcctcag cggccgctgg gcagggacct gcactggagg ctgaagcaca ccggcctcga
      601 cgtcgcgccg gtccgccgct ggctggagaa ggtgccggtg tcggtgctcg acgacggcac
      661 ccaccgtacg gccctcaagg cgcacggtgt cgacgagcgg gcgatgttca cccggttcac
      721 cggcgacggt gtcatctggg cggacggcac gaaggagacg gtcgacgcgg tcgtcctggc
      781 caccggctac cgcccggctt tcccctacct ccacggcacc ggctccctgg acggcgacgg
      841 actcgccttg caccgtggcg gtatcgcctc agcggtgccg gggctggcct tcgtcgggat
      901 ggagttccag cgcagcttct cctccaagac cctgcgcggc gtgggccgcg acgccgggca
      961 tgtcctgtcc cggctccgcc gccagagccg gtgaggggtg cgggtcggct caggacagaa
     1021 gcgcggcgat ctcggcggtg gcctcgcggg ccggccgccc gaccccgatg agggtggccg
     1081 aggccggccc cgtccagtcg ccgtagccga gcaggtgcag ccgcggttcc tgcacggcac
     1141 gtgtgcctgc ggtttcgatg tggccccggc tgccgcgcag gccgagcggg gcgaggtggg
     1201 acagggcggg gcggaacccg gtggaccaga tcaccgcatc cgcctcggcg tgcgtcccat
     1261 cggcccaggc gatgccgtcg gtggtgaggc gggtgaacat cggctccgcc ttgagcagtc
     1321 cggcgtcccg ggcagcgcgg accggcgcga ctgcgacgat gtcgccgagc gaggcgacac
     1381 cgccgctgtc cgccatgccg tcctccaggg cacggcggcg ggcggtcgcg gcgtcgaaca
     1441 gggcgcggcc gtcgatattg tcggccagga accgaggcgg gcgctgggtc acccaggtca
     1501 gggagacatc gtcggccagg gcgaggtcgg cggcgatctg cgcgccggag ttcccgccgc
     1561 cgaccacggc gacccgttgt ccggcgaagt ccgccgaact gcggtagccc gtggtgtgca
     1621 gctgacggcc ggtgaagacc tcccggccgg gaacggccgg gaggaaaggc cgccaccacg
     1681 tgccggtggc cgagacgacc gcccgcgcgg accagacgcc cgcatccgtc tccacccgca
     1741 accggcgccc gtcgcggagc acggaagcga cgcgaaccgg acggtggacg ggcaggtcgt
     1801 agcgctgctc gtagtcggcc aggtagtcca cgacatgtcc ggcatccggg tgctcctggc
     1861 cgctctgcgc gggcatgagc cgaccgggca gggaggagaa cgcggccggg gagaacaggc
     1921 ggagcgagtc ccaggtgtgg cgccaggcgc cgcccggctc gttctgggcg tccaggatca
     1981 cgaagtccag cttcttgcgg cgcaggtagt atccggcggc gagccccgct tgcccgccgc
     2041 cgatcagtac cacgtccgcc acgccggtca cggagtcaga gccgtcgcgg ccggggattc
     2101 ggctgcggcg cacaccgggc acagcaccct gcgggccggg gcttcaccga aagccccggg
     2161 cagggggccc cgacgcacac tccgggccgc gatgcgcgta tgccccgcac agaccccggc
     2221 tccgcagccg tggcagatgc cgacggtcgc gctgtgcgtc ccggtggcgt ggcagtcgag
     2281 gcagtgcatc agctgtccct tcccggtgtg gtgagtgcag tgggcgcgaa cttcttgcgc
     2341 caggccagcg cgacgtacac gaggccgatc aggaccggca cttcgatgag cgggccgacg
     2401 acgccggaca gggcctgccc ggaggtgacg ccgaaggtgg cgatggcgac ggcgatggcg
     2461 agttcgaagt tgttgcccgc cgcggtgaac gcgagggtgc tcgtgcggtc gtaggcgagt
     2521 ccgaggctct tgccgaggag gaacgagccg aagaacatga tcgcgaagta gaccagcagc
     2581 ggcagggcga tccggacgac gtccatcggc tgcgaagtga tcgtctttcc ctggagtgcg
     2641 aagaggatga cgatcgtgaa cagcagcccg tacagcgccc acgggccgat cttcggcagg
     2701 aacctggtct cgtacttctc gcggcccatc ttcttctcgc cgacgcggcg ggtgaggaag
     2761 ccggcgagca gggggatgcc gaggaagatg atgacgttca gcgcgatgtg ccagacggac
     2821 acgtccaggc cctggccgtc gccgaggttc agccagcgcg gcagcaggtc gagatagaac
     2881 cagcccagca cgccgaaggc gaagacctgg aacaccgagt tcagggcgac gaggacggcg
     2941 gcggcctcgc ggtcgccgca ggcgaggtcg ttccagatga tgaccatggc gatgcagcgc
     3001 gcgagcccga cgatgatcag gccggtgcgg tactcgggca ggtccggcag gaagatccac
     3061 gccagggcga acatcaccgc cggtccgacg atccagttga tgaccagcga ggacaccatc
     3121 agcttcttgt cgccggtgac gcggtcgagc cggtcgtagc ggaccttggc cagcaccgga
     3181 tacatcatga ccagcaggcc gagcgcgatc ggcagggaga tcccgccgat ctcgatcttc
     3241 gcgagagcgt cgttcatccc ggggatgagg cggcccaggc ccaggcccac ggccatggcg
     3301 agcaggatcc acaccgcgag gtagcggtcc agggtggaga gcttcttgac gatcgagtcg
     3361 tcaacggccg ggccgggccc gtcggtggag gcggtggcgg gctcggtgga ggtcacgggc
     3421 aggccctctt gttctcgaca gcggtgcggg cggagtcagc aagctcggcg aactgcgtgg
     3481 acaccgaggc cagtacctcg gggcgcagct tgaagtaggt gaaccggccg cagggctcgg
     3541 tctccaccag accggcctcg cgaaggacct tcatgtggtt ggacaggttc gtctgcttgg
     3601 caccggtctc ctcgaccaga tgcgacatgc agagcgtttc ccgggccagc agggcaacga
     3661 cctgcatgcg cagcggatca cccagaaccc ggattacgtc agtgtcgact gaagtcatca
     3721 tgggctgata ctgtcacatc attcggcgct gacaccagtc cgagctgaac cgtagggccc
     3781 gtcgaagggg ttcccatgtg cgtcccgcca ccacccgcct ggcccgacga gcggctcggc
     3841 gccggggccg cccgcctcgc atcccgccac cgcggccatt tctccgtgga gaccgtgcag
     3901 cagctgctca ccgactccta ccggcgcctc gccgagaatg cccgggtccg tacacacctg
     3961 gtggtacggg ccgagcgcct gaccgcagag cgcctcgacg ccctcgccca caccggggca
     4021 ccgggcaagg gcgtggtccg ggtgctgttc gtgtgcgggc acaacgccgg ccgctcgcag
     4081 atggccgccg ccctcctggc ccaccgggcg ggcgagcgcg tgatcgtttc ctcggccggg
     4141 accgatccgg ccgccgaggt cgagccgcac gtcgcgcagg tcctcctgga gtcgggactg
     4201 tccatcgccg acgcgtaccc caagcccctg accagtgagg tcgtcggggc cgccgactac
     4261 gtcatcacga tgggctgcgg agacgcctgc cccgtggtcc ccggccggca ctacctggac
     4321 tggtccgtcg ccgaccccga cggcgccccg atcggcgtcg tacgcaccat ccgcgacgac
     4381 atcgacgccc gtatcacccg ccttctggcc aacctcccag acacctgaca tcgccttccg
     4441 aagcccgtgc cgatccactt caccaaggga agaacaatgt ccgacaagcc ctctgtcctg
     4501 ttcgtctgcg tccacaacgc cggccgctcc cagatggccg ccgcatggct gacccacctg
     4561 gccggagacc gcgtcgaagt ccgctccgcc ggatccaacc cgggcaccgc cgtgaaccct
     4621 gccgccgtcg cggccatggc cgaggtcggg atcgacatct ccgcccagac cccgaagatc
     4681 ctcaccatcg acgcggtcaa ggagtcggac gtctgcatca ccatgggctg cggcgacacc
     4741 tgccccgtct tccccggcaa gcgctacctg gactggcagc tcgaagaccc ggccggccag
     4801 ggcgtcgaag ccgtacgccc catccgcgac gagatcaaga acctggtcga gggcctgatc
     4861 aaggagatcg ccccggagaa gaccgcgtga gcgagatacg cgaggtcgtc atcgtcggct
     4921 ccggccccgc cggatacacc gccgccctct acaccgcccg cgcccggttg aagcccctgc
     4981 tgttcagcag cagcatcttc gtcggcggct ccctgacgac caccaccgag gtggagaact
     5041 tccccggttt ccccgaaggc gtggacggac ccgtcctcat ggagaacatg cgggcgcagg
     5101 cgatgcgctt cggcgccgag atgatcgacg acgacatcgt ctccgtcgac ctcgccggcg
     5161 acatcaagtt gctgaccgac tccgagggca ccgtgcaccg cgcgaagacg gtgatcgtcg
     5221 ctaccggttc cggctaccgc aagctcggtc tgcccaagga ggacgagctc tccgggcgcg
     5281 gggtgtcctg gtgcgcaacc tgcgacgggt tcttcttcaa gggccgcgac atcgtcgtgg
     5341 tcggcggcgg cgacaccgcc atggaggaag ccaccttcct cacccgcttc gccaagtccg
     5401 tgaccgtcgt ccaccgccgc tccaccctgc gggcctcgaa ggtcatgcag gaccgggcgt
     5461 tttccgacga caggatctcc ttcgccctcg acagcgagat cgccgagatc aaggagaccg
     5521 gcggcatgct ggccggcgtc gttctgcgtg acgtattgac cggcgccacg cgcgacctcg
     5581 acgtgacggg gctgttcatc gcgaccggcc acgacccgcg caccgaactc ttcaagggcc
     5641 agctcgacct tgacaccaag ggctacatcc aggtcgcatc gccgtcgacg cgcaccagcg
     5701 cgcccggggt gttcgcctcc ggcgacgtcg tcgaccaccc ctaccggcag gccatcaccg
     5761 ccgcgggaac gggcgcggcg tcggccctgg acgctgagcg ctatctcgca gcccgcaaca
     5821 ccgcccaggc tcagcaggag cctgccacaa tcccggcctg accgaacctc accacggcgc
     5881 gtgcccctac tcggcggccc ggacgaatcc tgagcggccg catggttctc cccgaggctg
     5941 gggcggtggt ggacagagac cgctaccagc gaaggtggcc gccatggcca ccgggtagaa
     6001 ccgcgccccc tctgcgaaca acgcactcga cacctcgggt gttcggtgcg gaagtggccg
     6061 tcggcattca gggatcttga acaaggtcaa gccgtgctgg ccaccatcac cccgatacgc
     6121 cgcccagccc tcctaccagg ccaccggctg gccgctctcc gcgtcgacgg cgggcattcg
     6181 ggcctgccga cggcgctgca ggaccgcctc ggatgaaccc gcgcgcactc cgctcacccc
     6241 gtcgaggcgt ggaactcgac gacgactggt tcgagctgac gtctgaggtc gtcgacgcat
     6301 aggcatcgag ccggataccg acccggcggc ctggctgtga gtagccatgc gcagccaggc
     6361 cagcgggctc gacatcgtcg ctcccggtca tccgtcaggt cggccgttgg gcccaggtac
     6421 acaacgacgc ctgcttcgcc cgcgccgcct gcgcgaactt cacctacgac cacggccttg
     6481 acgccccggg cgagcggcgg ggacggcctc ccgcccactg agggtccagc gtggccaggc
     6541 ccttctcgtt gaacgcatgg atgacgtccc ggacggtgtc ctcgtgcgcg gcgaccaacc
     6601 gggcgatcgc cgttaccggg gtgcccgacg ccgacgccat gatgatcagt gcacgacgaa
     6661 cccgcacgga ctcatggcgg ccccgccgga cgatctgctg gagtctttgc ccctcttgat
     6721 cagtcaaccg ccgtgctcgg accggctctg ccatcgatgg cctcactctc aacagcaatc
     6781 acattgtcat cgagagtgag gccgacagac cctggcaccc cgaacatcga ccggcgtgtc
     6841 acccgacccg gcgaacgttc gtggccaacg cactagccaa ctcgacgggc ccgcgccgga
     6901 gccgctgacc gcccggctcc gggccttccg gagcatcggc tccgaccgaa gcagcacctc
     6961 cgaatgccgg gagttccgcc atgcccgacg ccaccgcgct cgaccaggcc acagccatga
     7021 tcgagaaagc ctggagccgc cgacggcact ctctgcccgg cggagcacaa gcacaccagt
     7081 tccggtaagc cgctccaccc cggctgcccc ggccgcgcgt tcacggaggc catctgcgcc
     7141 tgtggcggct gggggatgaa ggaatccggc aagggctacg tcaacgagag ccgtaagcgg
     7201 cacctcgcca gtcacgccca ggggccgaag gtccttcgcg accagcttcg agtcgatggc
     7261 tcctgacgct ccaccgctcc accgcccatc ccggtctgcc atcccgttcc gatctcggag
     7321 gttcccgtgc cccactacct gaccgtcggc cacctgctcc gccagctcca ggaccttgac
     7381 cccaacctgc cgatccgcct cgccatcaac cccgacttcc cccgctcgac atcacctggc
     7441 tctccgccga aaccccgaga ctccctcttg gccgcattcg cctgcgcggg gagcccgcct
     7501 ccctctcagg ctgggacgtc accgcccacc tgggccttgc caccagcgag gtacatctca
     7561 cctcctggcc tgccgccccg gacgactggc cgtgcctggt ccgcccaacc catccacgag
     7621 gtactcggcc tctgcgccgc cctcgcggtc gcgaccgccg ccctcgaact ctcgaatcgc
     7681 ctcgcccctg tctgaccgaa accgcagaag gccgcccctg tgccaaccag gcaggggcgg
     7741 acctgccgtc gagccgacag cgcaaccggg gaagggggta gcgttttccc ggttcgccgt
     7801 cggagtcgag gagacgggcc acggtcttcc cgagattccc gcgcatctgc ataccgatcg
     7861 ttcaccgata ctgcccggcg aagaatcagg atgaacacaa atataccggc gacctatgtt
     7921 gaacgtcgtt gccactgaat gcgaacactc gccgtgcccc aaacacctgt cgtggtttta
     7981 cccggatgag ctcctccgtt ggaagagtct cttctcatct gccttgaccg caccctgagt
     8041 tggagcttca gccgggcctg tgctgtggct ggtttaccgc tggtgctggt ggtttcactg
     8101 tcctagcgtg atgcgaggtt cgtgtgggtc cgagctttca ctgcgcgata cgccgcccat
     8161 aagtcggcct cgaatacggt cgcctttttc gcaccgctac acgccaaggt ctgttccgtc
     8221 cgcgtgcctg gaggactgat tatgcgttca gcgatcaaga gcgccagcta tccgaatagg
     8281 gagtcgctgg ccgaggcagc tgctcgcctg ctcgtggaga agattgcact gtgtacagct
     8341 gaggaggggc gctgcctggt cgcgttgtcc ggtggcagta cgcctgccgc tacctaccgc
     8401 ttgcttgccg gggccggtct ggactggggg gcggttcaca tcgtgcagac ggacgagcgg
     8461 gtgaccggtg tccggtcgga gacctcggcc gcggtcattg aggacaatct ggtgcggccg
     8521 gcccggatcc ccgcttcgcg ctggcatccg atgcccggca tcacagggga cgacctcgcg
     8581 cgcagcgctg ccgactacgc gcggactctg ggtgggctgg gcggtgacgg cacgcctgac
     8641 atcgtgcttc tggggctcgg ggaggacggt cacacggcgt cgctgttcga gggtgacact
     8701 gcggccgaga cggccgagcg ggtggcggtg acgatgccgt atcagggaac ggtccgcctg
     8761 accctgggtg ccggcctgct ggcgggagcc cggacgcgga tcgtgctggc ggcggggaag
     8821 gcgaaggcgc aggcggtttc gcggctgctg aacggcgacg taccggcggg tgatccggct
     8881 gcgcgcattc tgggtgagga cggcatgctg ttcgtcgacc atgaggcact ggcgtacagc
     8941 gaagccctgt gagacccgtg ctcgtgtttg atctgggcgg cagctggtgg cgtgtcggcc
     9001 tgttcacgga cgagcggcag gtacatctga tccggcgtga gccggcggtc aaccggagca
     9061 gcgcagacag gccggtgccc gttctccagc aggagctggt cgacttcgtg ctccgtcaca
     9121 cccgcgcgta tctgcgggaa cgtgccttgc tgcgtgtggg catctcgctc ggtgcggcca
     9181 tgaacggaca gaccggtcgt gtattggcca gtgcacccat gtggggcccg gaactcgcgc
     9241 cgttcgacct tcttgccgtg ttgcgggacg aacttcccgg actggcgtgg ggggtgctca
     9301 acgatgtctc cgcacttgcc gtggcgctgc gtgcccgtat gcccgccggc ggccggaagg
     9361 ccgctgcggt gacggtgagc agcgggatcg cctaccgcac catcgatctg cgcaccggtc
     9421 acatcccgtt ggatccggag catggcctgc agggagagat cggtcatctg cccgtcgact
     9481 tcgtgatgga gggacggagg gtcgaggcgc aatgcgagtg tggggcgagc gggcatctcg
     9541 cggccttttc gtcgggccga ggtatcgagg aactgctcgg agttctcccg gaagcagcat
     9601 ggctgcgcgc cggaagtgac gcgcccgcgg ggcctgtcgc agcgttcggg gtggcggtac
     9661 ggcggggtga tccgcgtgcg ctccgtttgc tggacgcttt cacccggccc ctgtcgcgca
     9721 ttctcctggc gcagacgacg ctcgacccgg aggtcggcca cacggtgctg agcggcggtg
     9781 ttgtcgacgg cctggagggc cactatctct ccagcctgct gcgcaacctc atggccgacg
     9841 gactgtatgg gatctctcat gccgatccgc actactttcg ccggcggttt gccgtgggaa
     9901 gcccagatgg actcgatcca cttcggggcg ccggtcttca cgtcgcaggt ctctcttccc
     9961 cgccagctca ggaacgtctt gacagacaag gactcacgtc atgaaatcct ggacggtccg
    10021 tgccacccag gaagtcagtt acgaggtccg gcagacccgt ggcgtactcg gcctggacaa
    10081 tccggatctc gccgatgcgg ccggactcga agccggtgcg cggcgcctgg tcgtggtcga
    10141 ccgggaggtc tgcaggatct acggcgccgg catccgtgcc tatttccgcc accgtgacgt
    10201 cgatccggtt ctgctcgtac tgcccgccga cgagtcgaac aagacggcgg cgtccgtgtt
    10261 caaggtggcc gacgccgcgg accacgtggg tctgaaccgg cgcagtgacc cgatcgtggc
    10321 catcggcggt ggtgtgctca ccgatgtggt gggcctggcg gccagtctct atcgtcgggg
    10381 gacgccgtac gtgcgggttc cgaccactct catcgggctg gtcgatgccg cggtgggggt
    10441 gaagaccgcg gtcaattacc actcccacaa gaaccgtctc ggcacttact ttccggctgc
    10501 cgtcactctg ctggaccagg gttttctgca gacgctaccg gtgcggcaca tcgtcaatgg
    10561 cctggccgag atcatcaaga tggcagtcgt ccgcgatgcg gggctcttcg acctgctgga
    10621 cgacaacgcc gagcgtctca tcgagcagat ggctcagggg gacttgggcc gcagagtgat
    10681 cgagtcggcg gtcgcgggca tgctcgggga actgacaccc aacctctggg aacacgacct
    10741 caagcggctg gtggacttcg gccacacctt cagcccgagt atcgaactgg ccgtggaccc
    10801 gccccttctg cacggggagg cggtcgccat cgacatggca ctgtcctgcc tcatcgcgca
    10861 ggagcgtggg ctgctgtcct cggccgaaac tcagcgttcc ctgggactga tgcgcagcgt
    10921 gggcctgcct ctgtcccatc cccgtgtgac tcctgaagcg ttgatcgacg ggctggcgga
    10981 ggcgacccgt caccgtgacg gaaaccagca cgtcccgctg ccgcgagggc tcggccggac
    11041 ggttttcgtc gaggacatca aaccgggcga gatccggcgg gcccagcggc gcagctttga
    11101 gctcaccggc atgtgggagg cggcatgaag cccaacctgg ccgtggtgcg ccatgggagg
    11161 accagcctcc tggaacagcg ggaacccccc gcgccggcac ccggacaggt gttggcacga
    11221 gttctgcgcg ccggtgtatg tggtaccgac ctgcagattc aacggaaagt ccggcccgac
    11281 gccgcggcag ttctcggcca tgaagggctc gcctcagtac ccgcgggaaa cacgactcgt
    11341 ccggtgatct tcaacccggt cgacccggag gcacaggatc gcgtgctggg gcacagctat
    11401 gacggcgtct tccagcacac ggtgctggtc gacgcggaca gccctgttct gttcgacgcc
    11461 gatcccctcc tgatcgctga cctggcacct ctcgtggagc ctctcgccgc ggtcctgtac
    11521 gggtgggagc tggtggagcg tgacgcccgg ccggccaccg ccgccgtatg gggcggtggc
    11581 agcaccgcgg ttcttaccgc actggtcggt gagctgcggg gtattcggac gcacctggtg
    11641 cacagacgcg ccgggcgtct gagctttctc accggacagg gcatcttcgg cgcgaccacg
    11701 ctccacaccg gagcttcggg ccttcgcggc attgatgcgg ccttcatttg tctgccgagg
    11761 gaagcggctc ccggcgcgct cagtgaggtg gtgtcctcgc tcgcccccgg cggcgtggtc
    11821 gacctgctcg gcggcttcgc accgggagat gtccacggac agattcccgg cgtggacctg
    11881 ggtgctgtcc ggcgagcgaa cgtctgcggt cagccccgcc ccggcgccac cacccgggcc
    11941 aggaccgggg acggcgcagc gatcgggctc accgggcacc gggggaccgc cccacatcac
    12001 ctggccgaag cacagcgcct tctgcgtgcc catccggatg ttttcggagc gctggtcacg
    12061 cacgtgctct cgctggaggc agccgcggcg gagctccagg cggtggccgc cggaagcgga
    12121 ccgtccgtcg ggccaccgga acgcatcaag atggtgatcg acctctgcat gcccggacgg
    12181 tcacaccggc cggccgatct gaccacgaca gtgggcgagc tgaaggtgac aggttgaact
    12241 ccgccggcac tgcctaccag cgacttgacc accatcacgg ccgcgtcacc gtcaccgaag
    12301 ccgtagtgag cgatcctgcg gggcgagcca tggtggtgat cgccccgcag cggatcggtg
    12361 tatgccgttc ggaccttcgc gaactgcggt cagaccggca ccagcggcgc gatttcggtc
    12421 atgagatcgt cgctgacgtc gtcgctgcca ccaagggcgt cgcggtgagt gtcggacagc
    12481 gggtcgtcct cgatccgcat ccccaactgc acacccgcac ctccggattc ggacagctgg
    12541 tggaactctc cgggactccg gacctcctgc gcgacgcgct cgtacccgtt cctcggacca
    12601 tgggcgtgga ccgggctgtg ttcaccgaac cgctcgcgtg cgcctgccac tgcatcgagc
    12661 gactccatac ggtcaccgat gaactcggca tggaccgcca agggccggtc gccgtcgtgg
    12721 gagcgggcat ggccggcgcg ctgatcgctg ccgggctcca cgcgtcccat gtaccggtca
    12781 ccgtggtgaa cagggggcat gagcggctgg actttctgcg tcgtcgcgag ttcctgccga
    12841 acccggtgct gggaggaccg gacgggagtc ccctgttctc ccgcaccgtg ctggcgaccg
    12901 cctacgccga acccgctcag atacggcagg ccctggacct gttgttgccg ggcggcctgc
    12961 tgctgctgtt cgcaggaacc agaccgggca tggaactggc cggtgtcgac atcgatgacc
    13021 tgcggcgccg cgaacgcctc gcacacgtgc gcgtggatgg acgccccctt gccatcgcgg
    13081 ggacccacgg tgccctacga accgacttcg aacacgctct gcaactgctg aaccgagcgg
    13141 ccaacggaga atggcgcctc ggtcctgccg tcgaacggct ggtcaccaga cgtatgacgc
    13201 tcgcgcaggc cgcgcggctt ctgcccgaac acgccgatcg cggctttctc ggcaaaccgg
    13261 tcgtcgtccc cacacctcgg agaagaccat gatcgtgacc aagtacaacc atcgctcgca
    13321 gttcgaggac ctggacgcgc tcacccacca gatccgggcg accctggaat ccggtgacta
    13381 catcctctct cccgccgtcg aacagttcga ggaacggctc gccgcccaca ccggagtggc
    13441 ccacgcggta ggggtgaact ccggcacaga cgccatcgtc ctggccctgc gcgccctcgg
    13501 tataggtccg ggcgacgagg tcatcaccgt cgccaacacc ttccacgcct ccgtgctcgc
    13561 catcaccagc gtcggcgccc ggcccgtgct ggtcgactgc acgccggact cctacctgat
    13621 ggaccttgac caggtcgatg ccgccgtcac tccacgcacc cgcgccctgc tcgcggtaca
    13681 cctgttcggc caggcactgg acatggaccg gatcgccgcc atcgcggacc gccacagcct
    13741 ggcgatcgtg gaggactgcg ctcaggccat aggcgcccgt tgggcgggcc ggcgggtcgg
    13801 cagtttcggg caggccggct gcttcagctt ccacccgagc aagaacctgg ccgcggcagg
    13861 cgacggcggt gcgctcgtga ccgacgacgc ggcgatcgcc cgccaggtca ggaccctgcg
    13921 aagccttggc caacaccagc agaacgatca cgtagagcgg ggctacaaca gcaaactgga
    13981 tgccatccag gcactcgtgc tgaaccacaa gctcgaccag gtggacaaat ggaacagccg
    14041 caggtcggac atagccggtg agtacgcacg tgccctcacc ggtgccgaac tgacgccaac
    14101 cccacccgca ggcgaacggc atgtcttcca cctctaccag gtcacgctcg cacaccgcga
    14161 ccacgtgctt gccgaactca cccggcatgg cgtagaggca gtcgtgcgct accccgtccc
    14221 ggtacaccgc caacgcgcgt tcgcggacct gcacctgccc gcccggttcc cccaggcgca
    14281 ggcccaggcc gaaaacacgc tctgcctgcc gatccgccca gacctcaccg acagggaagt
    14341 cgactacgta gtacggacgc tgctcaaagc ggtagcgccg tcccgtcgca atgccgccgg
    14401 ctgaccggcc gcgaaaacgg aggaccggat gaccacgatc gcccccgccc tgctcggcgc
    14461 tgacccgctc gcgctcgccg acgcgatcac cgaggtcgaa cgcgccgaag tcgacctgat
    14521 ccacctcgac gtcatggatg gacacttcgt ccacgacatc agcttcggac tcaacacggt
    14581 cagagccata cgcaagcgca cagccctgcc gctggacgtg cacatgcagg tgcagcggcc
    14641 cgagcaatac ctcgacgaac tggccgcgtc cggcgtggac accgtgtccg tacacgtgga
    14701 gagcaccctg cacctctcgg cggtcctgcg gcggctggaa accgcagaca tcaaacgcgg
    14761 cgtggtcatc aacccggcca cgcccctgaa caccctcgat gaagtgctcg accggatcga
    14821 ccaggtcgtc gtgatgacct gcaacccggg aaccagcgac ttccaggcgc agatggtgga
    14881 caagatccgc cgattgcggg ctcttctgga ggaacggagg atcgatcacg tgcgggtggt
    14941 tgccgatggc ggcatcaatg cctccagggc ccgcgtgctg gctgaggccg gagcggatgt
    15001 actggtcgcg gcgtcagccg tcttcagctc cacccatggc gacgtggccg ccggtgtagc
    15061 ggccctgcgc aaagcgatgt gaaaggacac agcagatgac gctcagtgcg gtcgcggttc
    15121 tgttcgatat ggacggtgtg ctcgtggaca gttccgggtg catctcccgc gcctggttcg
    15181 agtgggcggg acggcacggg ctcgatgccc aaggcaccct ggccctgggg cacggactca
    15241 ccacactcga ccacatccga gcagctgccc cggcgctggc cacggagaag gaggcagccc
    15301 tcatcgacga gctggaggac cggcacgtcg ccgccgtcat cgcacaaccg ggtgccgcgg
    15361 cggccacgtc ttccctcacc cgggcagacg tgccatgggg ggtggtgacc tcctgctccc
    15421 gggaagccgc cacagccagg ctggcgaccg ccggactccc tcttccatcg gttctcatca
    15481 ccgccgacga cgtgacacgg gggaaaccgg caccggacgg ctacctgacc ggcatctcgc
    15541 gcgtccgtgc cgagccgcac cggaccgtgg tgttcgagga tgccccgtcc gggatcaccg
    15601 cagcccaggc tgcgggagct cacgtcatcg ccctgtccac cacgcacgcg gcctcgcaac
    15661 tcctcgccgt cgactcgatc gtgcctgacc tgtccttcgt ccgcttccag cgggaaccgc
    15721 acaccaccga ggtggccatc gagatcctgg ccgcgcgggc cgcccagacc cgatgaggtg
    15781 aagcacgcat acggtgcagc gcatgtgagg gaacgcagac ctccggtcgg cgccggtcac
    15841 cgcgcgtcag atgccggacc cagatgcaca atgtctgctt cctcgtgcgc gccaggtatg
    15901 tgaggcggcc cctgcagaaa acatggccgg cacgagcgcg gcagagcggt gagcgcgccg
    15961 ggagaagcaa caggaaagcc cgagcgaagg ggacggcatg acacaaccgc tcactgtcgg
    16021 cgtcgaggag gagttcttca tcgtcgattc ggcgacccgg aacctcctcc cgcaatccgg
    16081 acagatcatt acctccgccc tggctcaagt ggacgaacag acaccgtccc ggttctgtga
    16141 ggagttccgg ccctgcatgg tcgaaagcag atccgggatc tgccggacac tggacgaact
    16201 gcgggccgat gtcatcacct cgcgaagcac cctcatccgc gccgcggagg aagccggagg
    16261 ccggatcgcc gctgcgggaa cgtatccgct ggcagactgg cggacacagg aattcaacac
    16321 caaaccgcag taccaacgga cggtcgagac ataccggctt ctcgctgacg aactcctgat
    16381 ctgcggctgc catgtgcatg tcggcgtcgc cgaccgcgat accgccgtcg aagtgatgaa
    16441 ccgcgtccgc ccgtggctgc ccgtcctgtc cgcgctggca gccagctccc ccttctggat
    16501 gggcgcggac acgggatact ccagctaccg cagcatggtc tgggaacgct ggcccacatc
    16561 cgggatgccc cccacattcc ggtcctacga cgagtaccag aacagtgttc ggctgtccgt
    16621 cgagtccggc atcagcccgg tggccggcga catcttctgg gacgtacgcc ccggcaccca
    16681 gtatcagacg gtcgagttcc gcatcgccga ctcgtgcgcc acggccgatg aagtcatcct
    16741 gcaagccgga ctgtgccgag cgctcgtaca caccacactc acagagatcg agaaaggaga
    16801 cacaccagcc gacatccgct cagaactgct gcgcgcggcc aaatggcgct ccacacgctt
    16861 cggactcacc gaccggcttc tcgacccgtt cacggccgca ctggtaccgg cgcacgagat
    16921 ggtggaccga ctgtgcgagc acgtccgccc gtcactggaa ggcaccgggg actggacggt
    16981 ggccagcggg atcaccgagc ggatcaaacg ccaggggaca tcagccgaac ggcaacgggc
    17041 tgtcttcgag agacgcaaga gcctcgaaga catcgtcgac catcaggtaa gggataccgc
    17101 cagctggtag atcccgcacc cacccaccgg gcatacaagg cgtgaggtag ttcaatccgc
    17161 atagctgggt aggggctgca caggtggccc ggccgtgtgc aggagggcag tgggtgagct
    17221 gatgtctgat gccgtatcag gcaacgtttt gccctgttgt gatgcgccgt ccgggtgtcg
    17281 gtccgggcgg cgtggacacg gcatgctgtt ctcgtggcag agcgggtgcg tgtccgggag
    17341 atgatgacga cgagggtcgg cggttgctgc ggatcatccg ccgcggtacg gggtcggtgg
    17401 tggcctggcg ccgggcccgg atggtcctgc tgtccgcgca gggcatgccc gtggcgaaga
    17461 tcgccgaggt gaccttcacc agcgccgacg ggatccgtga tgtgatccac aacttcaaca
    17521 ccgacggctt cgactcgctc tacccgaagt ccaagggcgg tcggccgaag acgttcacgc
    17581 tgcccgagcg ccgcgagatc aagaagatcg cgaagtccac gccgaccgag cacgacctcc
    17641 cgttctccac ctggagtccg accaagctgg cggacttcct ggtcgccgag gggggggtcg
    17701 gcgacatcag ccacgaggat ctgcgcatcc tgctccgcga ggaaggcgtc tcctttcaac
    17761 cggcacctgt tcgccgccta caacctggcc aaggacaagc tctacggaca catcaaaccg
    17821 gtcaggcggc ggacacagtt cctggaattc tgccgctacc cgcgcaccct ctgcccggcc
    17881 gaggtccgcc cggcaatcgt ctgcgacaac tgtgaggatc gtgatgtgcc gcagggggcc
    17941 ggagcctgac ccgtgcgaca actggccgca gctgccttgg agtggaactg tcggccccgg
    18001 cctcctgcgg tacgtactgc cgccggcccg gtgaacgtgt cccgataggg gctttgctgc
    18061 acaaagcacc gtcacagttc tgaccgccca ccggaccggt gtcagccgcc agccccagtc
    18121 caaggagctt cgtgaccgtc accagcatgc cccagccgac gctgcccgcg cagcaggtcc
    18181 ctgggg
//
