LOCUS       NZ_LWKZ01000025        23436 bp    DNA     linear   CON 28-MAR-2024
DEFINITION  Streptomyces sp. CB02923 scaffold5, whole genome shotgun sequence.
ACCESSION   NZ_LWKZ01000025
VERSION     NZ_LWKZ01000025.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CB02923
  ORGANISM  Streptomyces sp. CB02923
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 820273)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 820273)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra,H. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-APR-2016) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2016
            Assembly Method                   :: CLC NGS Cell v. 8.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905005.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:56:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,128
            CDSs (total)                      :: 8,049
            Genes (coding)                    :: 7,904
            CDSs (with protein)               :: 7,904
            Genes (RNA)                       :: 79
            rRNAs                             :: 2, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 145
            CDSs (without protein)            :: 145
            Pseudo Genes (ambiguous residues) :: 0 of 145
            Pseudo Genes (frameshifted)       :: 32 of 145
            Pseudo Genes (incomplete)         :: 128 of 145
            Pseudo Genes (internal stop)      :: 11 of 145
            Pseudo Genes (multiple problems)  :: 22 of 145
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:21:38
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 297971
            Orig. end                         :: 321407
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LWKZ01000025.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23436
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..23436
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23436
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:13436]"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13436
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    27..41
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.64"
                     /tool="antismash"
     gene            68..907
                     /locus_tag="A6A06_RS29485"
                     /old_locus_tag="A6A06_22500"
     CDS             68..907
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010350140.1"
                     /locus_tag="A6A06_RS29485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_22500"
                     /product="MOSC N-terminal beta barrel domain-containing
                     protein"
                     /protein_id="WP_242441012.1"
                     /transl_table=11
                     /translation="MGTMVGTVTTLWRYPVKSLLGEEVPDISANAHGLAGDRALALVHQ
                     TSGQVASAKNPRLWRDLLKLRAEIIDGAVRITLPSGRTVRSTDAHVHRTLTAHLGQPVT
                     LADTPPEKATLERSCPEEVLAAGTAAEVARETMEIATQAPPGTFFDYAPLHLITRATLD
                     RITELGPRATTVEAERYRPNVVIRTEAAGFVENDWPGRELRIGDELTLRVVARTPRCAV
                     PTLEHGRLPRDPDALRVPARHNRVVPMDDADPQPCGGVYAQVVRPGRIRQGDAVRVV"
     gene            complement(922..1455)
                     /locus_tag="A6A06_RS29490"
                     /old_locus_tag="A6A06_22505"
     CDS             complement(922..1455)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014673681.1"
                     /locus_tag="A6A06_RS29490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_22505"
                     /product="SigE family RNA polymerase sigma factor"
                     /protein_id="WP_073765160.1"
                     /transl_table=11
                     /translation="MTTPVCTSASRAAVFPSFSSYVRARGPVLLRTARSLTANPSDAED
                     LLQTALAKTFVAWERIEDHRALDGYVRRALLNTRTSQWRKRKVDEFACEEIPEPDPDPA
                     PDPAEAQVLRDAMWRAVLRLPARQRAMVVLRYYEDLSEAQTAEVLGVSVGTVKSAVSRA
                     LAKLREDPELSVAA"
     misc_feature    1449..1462
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 18.51"
                     /tool="antismash"
     gene            complement(1662..2522)
                     /locus_tag="A6A06_RS29495"
                     /old_locus_tag="A6A06_22510"
     CDS             complement(1662..2522)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003983529.1"
                     /locus_tag="A6A06_RS29495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_22510"
                     /product="DUF1906 domain-containing protein"
                     /protein_id="WP_073765162.1"
                     /transl_table=11
                     /translation="MGSTKRIIRRRAPRPAALLTALTGLLGLLATVLAPAAGAEPDRTG
                     PRGPNVFRGWAFDTCKAPPQSTLQAWKGSKYRGIGIYFGGRGRACPSQPNLTPGWVRAA
                     HRAGWRMLPLYVGSQAPCVVNKSKRKATIGGDPAQVGASEARDAVRRAKALGIAPDSAL
                     YLDMEAYSLRNAPCTRKTLDYIRAWNRETSRQGYVPGFYSSADSGVRHMERARQAGAQD
                     LPSVMWFARWHSKPNLYGEPELSGKAWRPHRRIHQYAGNVAESHGGRRLVIDRNQVDAP
                     VAVIE"
     misc_feature    2503..2517
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.58"
                     /tool="antismash"
     gene            complement(2700..3866)
                     /locus_tag="A6A06_RS29500"
                     /old_locus_tag="A6A06_22515"
     CDS             complement(2700..3866)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018513698.1"
                     /locus_tag="A6A06_RS29500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_22515"
                     /product="lipid-transfer protein"
                     /protein_id="WP_073765164.1"
                     /transl_table=11
                     /translation="MSLRRADTLGGRAAIAGIGATEFSKDSGRSELKLAVEAVRAALDD
                     AGLAPGDVDGMVTFTMDTSPEITVAQAAGIGELSFFSRVHYGGGAACATVQQAALAVAA
                     GVAEVVVCYRAFNERSGRRFGSGVQRREPSAEGTALGWNLPAGLLTPASWVAMAAQRYL
                     YAYGLTPEAFGQVAVVGRRYAARNPAAYFHGRPITLADHAASRWIVEPLRLLDCCQETD
                     GGQAVVVTSAERARDLRRPPAVIRAAAQGAGRAQEQMTSYYRDGLTGLPESAVVARQLW
                     RTSGLRPADIDVGILYDHFTPFVLMQLEEFGFCAPGEAADFVAAGGLPINTHGGQLGEA
                     YLHGMNGIAEAVRQLRGTSVNQVPGAAGVLVTAGTGVPTSGLVLGADG"
     gene            complement(3863..4336)
                     /locus_tag="A6A06_RS43130"
                     /old_locus_tag="A6A06_22520"
     CDS             complement(3863..4336)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008741013.1"
                     /locus_tag="A6A06_RS43130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_22520"
                     /product="MaoC/PaaZ C-terminal domain-containing protein"
                     /protein_id="WP_073765166.1"
                     /transl_table=11
                     /translation="MRPGDVLPPLTVPVTRTLIVAGAVASRDYQDVHHDAEAARAKGSP
                     DIFMNILTTNGLVGRYITDCLGPRAVLRKVAIRLGVPNYPDDVLELRGDVLAVDGDTAE
                     VRVVGTNRLGHHVTGTVTVTVPAAPAPAPAPAAASVSAPADVPRVAPGQEVTP"
     misc_feature    complement(4064..4066)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(4333..5475)
                     /locus_tag="A6A06_RS41195"
                     /old_locus_tag="A6A06_22525"
     CDS             complement(4333..5475)
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0016836 - hydro-lyase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014061875.1"
                     /locus_tag="A6A06_RS41195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_22525"
                     /product="bifunctional MaoC family dehydratase
                     N-terminal/OB-fold nucleic acid binding domain-containing
                     protein"
                     /protein_id="WP_242441013.1"
                     /transl_table=11
                     /translation="MDGGAGVAESELAEDELAEDELYVRLKAFEGQAAVTGGEGKDPVN
                     EPMIRHWCEALGDTGPAYRGPGAVAPPTMLQAWTMGGLSGHPGRSPAYDTLFGLLDEAG
                     CTSVVATDCEQEYLRPLRPGDRVTFDAVIESVSPRKTTKLGTGYFVTTRTDIRADGEPA
                     GTHRFRILKYAPAGQPESESEPVPEPVPVPEPVPELVSNPARGASAQPRTSGTSRRPRP
                     VINRDNAGFWAGVARHQLLIQRCTDCATLRFPWLPGCNSCGGEGWDTVEAAGSGTVFSY
                     VVLHHPPFPAFDPPYAVGLVELAEGVRMVADVVGVAPDQVRIGMPVQLEFRDVDEDLVL
                     PVFNGGATEPSALDDGDTGLSALDGGDTDPSALDGGGRQA"
     gene            complement(5725..6030)
                     /locus_tag="A6A06_RS29515"
                     /old_locus_tag="A6A06_22530"
     CDS             complement(5725..6030)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003983526.1"
                     /locus_tag="A6A06_RS29515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_22530"
                     /product="hypothetical protein"
                     /protein_id="WP_073765168.1"
                     /transl_table=11
                     /translation="MANVRTTRALTALAALPLAAALLAGVAHADNGGLAGNGSSAAATS
                     QAGTGVGHNNNGNSTTTQQVANGPGASNQNNTASVNGHGLTHIDQTDATVNFANLW"
     misc_feature    6418..6431
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.17"
                     /tool="antismash"
     misc_feature    complement(6427..6442)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 23.09"
                     /tool="antismash"
     gene            6453..7352
                     /locus_tag="A6A06_RS29525"
                     /old_locus_tag="A6A06_22540"
     CDS             6453..7352
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009716602.1"
                     /locus_tag="A6A06_RS29525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_22540"
                     /product="bifunctional DNA primase/polymerase"
                     /protein_id="WP_073765172.1"
                     /transl_table=11
                     /translation="MASPHTAATDTATGSHPSHPGDHATALTHALVAAGRGYSVIPLTR
                     AKLPAVRSPHHADRAPAPCRGACGRPGHGIHDATRDPLAVRHLFAAAPWATAYGIACGV
                     PPHHLIGIDLDTKHSADGLTALQLLAGEHRFTLPPTLTVHTPSGGRHLYLSGPPSPSVP
                     NSAGRLAPGIDIRGAGGYLVGPGSRTSRGRYRPASGVPRSPAPAPPALLTLLAQLPPTT
                     HHPKTSPVPAAHPAPALLRFVRTSPDGQRNARLFWAACRAYASGIGQEMATALTTAALD
                     TGLTEREARATIASAARR"
     gene            7470..8387
                     /locus_tag="A6A06_RS29530"
                     /old_locus_tag="A6A06_22545"
     CDS             7470..8387
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (64-180). E-value: 1.2e-21. Score:
                     68.3. Matches aSDomain: nrpspksdomains_A6A06_RS29530_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004993439.1"
                     /locus_tag="A6A06_RS29530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_22545"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_073765174.1"
                     /sec_met_domain="PCMT (E-value: 1.6e-05, bitscore: 20.2,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDPDRLADSYSDTNPFFRLFRHMGWGALVNLGYYTIPTLPALLGG
                     VAFFQRRLETRCLELLQARPGHRVLDACCGRGHTTARLGAAGCSAVGVDISGQQIAQAR
                     SRYGAAPNTAFAVADVTALPGQASGFPVADRPFDRIHCLEAAFHLSPAGRRALLAEAFR
                     VLRPGGRLVLVDFTWRTADPDTIHGLDPRGLLRAAWQIEGFEPLTRYLVHAEAAGFRVS
                     RTVDWTRPVVERSLRLGAVLSRMAASRGGREVLGLRWAGLREFTEQDWQTTIATIDAHQ
                     SVGRGVGYSALVLDKPGAEGGRAR"
     aSDomain        7662..8009
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A6A06_RS29530_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="1.20E-21"
                     /label="A6A06_RS29530_oMT.1"
                     /locus_tag="A6A06_RS29530"
                     /protein_end="180"
                     /protein_start="64"
                     /score="68.3"
                     /tool="antismash"
                     /translation="PGHRVLDACCGRGHTTARLGAAGCSAVGVDISGQQIAQARSRYGA
                     APNTAFAVADVTALPGQASGFPVADRPFDRIHCLEAAFHLSPAGRRALLAEAFRVLRPG
                     GRLVLVDFTWRT"
     gene            8384..9148
                     /locus_tag="A6A06_RS29535"
                     /old_locus_tag="A6A06_22550"
     CDS             8384..9148
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010468022.1"
                     /locus_tag="A6A06_RS29535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_22550"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_338015964.1"
                     /transl_table=11
                     /translation="MTSRRSPSQEQVPAQEHAASQPQEHTASQEHAASQEQAAAKEHAA
                     AAVQAECPLRLRISGVWKGYGRREVLRGADLSVPAGALVGVVGENGAGKSTLLRLAVGE
                     LAPDRGTVARTASVGYCPQRAVLNDTLTVGQHLRLFRTAYRLPDLDRAGELMDLLAFTG
                     CRDQQAGSLSGGTRQKLNLLLALMHDPDLLVLDEPYQGFDWDTHQRFWRLAGRLRDKGR
                     SIVVVSHLLHDLEHFDAVGRLREGRIESEGHH"
     gene            9148..9966
                     /locus_tag="A6A06_RS29540"
                     /old_locus_tag="A6A06_22555"
     CDS             9148..9966
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003981442.1"
                     /locus_tag="A6A06_RS29540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_22555"
                     /product="ABC transporter permease"
                     /protein_id="WP_199931253.1"
                     /transl_table=11
                     /translation="MGHRWAAFTEMLRCSLLGHLRNRLAMVLACVFVPVWIIVGRVCAL
                     DTVVRYRLDILDVDAVGLANRVGQVSNALSAIMLITGFMMFTETFKAGEMDRRLVLAGY
                     SRLPLLLAKVAALFVVASVLAGYTVVWLSLFLPVEQFWPLVLALLAAGLAYGGIGLLLG
                     SLVRGELEGFFTVVMLSLIDSGVQNPALEAANLPGLSVLPSYGAAQSALAASFTRTGPG
                     AHPLLAVAWCAATLALTLLVFHVRTRSYRTGTGSLAARAGAEAVARCPAA"
     gene            complement(10001..11203)
                     /locus_tag="A6A06_RS29545"
                     /old_locus_tag="A6A06_22560"
     CDS             complement(10001..11203)
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003963150.1"
                     /locus_tag="A6A06_RS29545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_22560"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_079194438.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 2.4e-51, bitscore:
                     170.0, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSTPTTKLPAERPASRPAAEEETFQELLARWAGRVDAQIERLYP
                     GTPAGCRDAGSPLMAYDCGGEPTDCSGDPAHARVGGRLHAALTEPVRYLVGAGGGRWRP
                     GLMMAVIEVLGGDSEHFGPLVASMELAHTGSLMVDDVEDGASLRRGRATVHTAFGTSTA
                     LNAGTFAYFTLDRAVRLTVPEDLVLRARLYDAYLAALRAAHAGQALDIQGHRTEMDQAV
                     RTEDAEPALEAVRLTHRLKSGAMVGAGLEAAALVCGVDDRQRTALVAFGSAIGTAYQIT
                     DDVADLEGVVRDGVVTKQVGEDLHNGKVTMPLAHAVARLPRRRLAPLWHAVRDGRADRT
                     TVLGAAAELRDCGALEACVREAQSLVAETWSRLEPMLPQVPGTRMLLDMARHVVQVNRI
                     A"
     misc_feature    11200..11215
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.27"
                     /tool="antismash"
     gene            11430..13436
                     /gene="shc"
                     /locus_tag="A6A06_RS29550"
                     /old_locus_tag="A6A06_22565"
     CDS             11430..13436
                     /EC_number="5.4.99.17"
                     /GO_function="GO:0051007 - squalene-hopene cyclase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019746 - hopanoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="shc"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014628573.1"
                     /locus_tag="A6A06_RS29550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_22565"
                     /product="squalene--hopene cyclase"
                     /protein_id="WP_073765178.1"
                     /sec_met_domain="T2TS (E-value: 1.5e-81, bitscore: 270.0,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTTDDESRPDGTLSSTPDPAPTFAFPPSDEVEEAARQAALKAA
                     DNLLARQHPDGYWREFLGVNTSMDAQDSLMRQFLGILDDRTAAATGRWIRSKQLPDGSW
                     SPVHEGAGDLGITIESYLALRLAGHDPDEPHMRQCAEWVRERGGLAAARVTTRIWCAMF
                     GWWSWDRLYEVPPEMILLPKWAPLNVYSYLYWMRQVVVPYLVVLSHRPVAPVPFGIDEL
                     LAVPGTHAGTRTDGPSGGWDGVFRGLNRALRWYRKAGPSSVRRAAVNACLRWITERQEA
                     DGSWGGVRVQTMWSVFALRHSGYPLDHPAVRAGLGFLDHTIVWPEEGVRKVEICESPVW
                     DTALSVIALRDTGLPGDHPALVRAADWLVGQQTTRRADWSVQRPRLATGGWAFQFHNEC
                     YPDMDDTSEVVLALHRVRHPDPARVDAAVRKGAHWNLGMQSKNGGWGAFDADSVSPIPE
                     RLALTGISFIADAPSADISGHVLEMLGALGMQDDIRTRRGIRWLLAQQEDDGSWFGRWG
                     VNHVYGTGAAVPALIANGVPPGHPAVRRAVAWLRSVQNADGGWGEDWESYTDPRYIGHG
                     PSTPSQTAWALTALLAAGERDSEAVRSGIRRLADTQRDDGTWDEPYHTGTVIPGEYALH
                     YGLYAHAFPLTALGRYVQHQNEGAIAGARPGPA"
     misc_feature    complement(13568..13577)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 15.86"
                     /tool="antismash"
     gene            13837..14448
                     /locus_tag="A6A06_RS29555"
                     /old_locus_tag="A6A06_22570"
     CDS             13837..14448
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A6A06_RS29555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A6A06_22570"
                     /product="hypothetical protein"
                     /protein_id="WP_199931254.1"
                     /transl_table=11
                     /translation="MADDGSGQWIRPVSNRSTHEVSEHERQYADGSDPKVLDIISVPLL
                     RPQPHGFQSENWLLDPEYYWEKTGRAGWGSLLKLEQHPNTLWTNGNSTYHGCNNRVTAD
                     QADALPDSLKLIRVDRVTLQVHVPGAAFNDPKRAVDAHFHHADCKYILRVTDPEYEQTY
                     LARSDGIYRLNESFLSVSLSEPHEGYAYKLVAAIIERAKI"
     misc_feature    14092..14094
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    14161..14163
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    14203..14205
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    14413..14415
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            14463..15077
                     /locus_tag="A6A06_RS29560"
                     /old_locus_tag="A6A06_22575"
     CDS             14463..15077
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016246.4"
                     /locus_tag="A6A06_RS29560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_22575"
                     /product="DUF488 domain-containing protein"
                     /protein_id="WP_073765182.1"
                     /transl_table=11
                     /translation="MTPPTAFTVGHSTHSVSHFLSLLQKHEITAVADVRSTPASRFTPQ
                     FNRDALKRSLSDADIKYVFLGDELGARTRDTTCYVDGRVQYSRLAETPDFISGIDRLQN
                     GAQTERIAIMCTEQEPLDCHRCVLVARTLEERGTAIAHIHGDGHIESHTMAMQRLLAGF
                     GLDQAELFRTPAERLQEALSRQEQRIAYVDEELRINGTPEK"
     misc_feature    14766..14768
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            15074..15511
                     /locus_tag="A6A06_RS29565"
                     /old_locus_tag="A6A06_22580"
     CDS             15074..15511
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016246.4"
                     /locus_tag="A6A06_RS29565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_22580"
                     /product="DUF488 domain-containing protein"
                     /protein_id="WP_073765184.1"
                     /transl_table=11
                     /translation="MKLHTIGFTKKSAEKFFGLLKEAGVTTLVDVRLNNVSQLSGFAKR
                     DDLKYFLGEICGAQYAHRIDLAPTHDMLDDYKKRRVDWATYEEQFVELIKNRRIEDTVP
                     RELLDNAVLLCSEPTAHHCHRRLVAEHLAQQWGDVTVSHLT"
     misc_feature    15188..15190
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     tRNA            complement(15598..15685)
                     /anticodon=(pos:complement(313620..313622),aa:Ser,seq:tga)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="A6A06_RS29570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="A6A06_22585"
                     /product="tRNA-Ser"
     gene            complement(15598..15685)
                     /locus_tag="A6A06_RS29570"
                     /old_locus_tag="A6A06_22585"
     gene            complement(15727..17484)
                     /locus_tag="A6A06_RS29575"
                     /old_locus_tag="A6A06_22590"
     CDS             complement(15727..17484)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018542566.1"
                     /locus_tag="A6A06_RS29575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_22590"
                     /product="trypsin-like peptidase domain-containing protein"
                     /protein_id="WP_073765186.1"
                     /transl_table=11
                     /translation="MSTENEGAAVPPEAQPPTAPQASDSAPESGARPSEGAGARGAADA
                     PQAADRADTAAGAPGASSASAATPPAAPPPPEFAPTAGQAGPADGTPAGTSDRTQQFSK
                     PTGPQAPQEPQDHPHPAGGPHTASQPHTAPQPQPYADAQSYPGAESYPGAQHGEGAPSH
                     PTTPPSYATAAHGASGGGWGSPPPGYGGGGAGGPDGVWGAPGAPAPKKRRNGGLIAAVL
                     VAALVAGGIGGGIGFWAAGRDDANSTTVSASGDPEALNRKPTSVSGIAQKALPSVVTIE
                     AQGATGEGGTGTGFVYDKQGHILTNNHVVASAAQGGKLTATFSNGKKYAAEVIGRAQGY
                     DVAVIKLKNPSDANLVPLPLGKSANVQVGDATIAIGAPFGLSGTVTTGIISAKNRPVAS
                     SDGGNATPSYMSALQTDASINPGNSGGPLMDASGSVIGINSAIQSAGNGGGGFGGESQS
                     GSIGLGFAIPIDQAKRVADDLIRKGQPVYPQIGAQVLMRDTGDGATIAQDGGAGGSASI
                     TPNGPADKAGLKPGDTITKLDNTVIDSGPTLISTIYQHKPGDKVTLTYKRGGKELTTQV
                     TLGQRTGDK"
     gene            17773..18615
                     /locus_tag="A6A06_RS29580"
                     /old_locus_tag="A6A06_22595"
     CDS             17773..18615
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978994.1"
                     /locus_tag="A6A06_RS29580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_22595"
                     /product="glycerophosphodiester phosphodiesterase"
                     /protein_id="WP_073765188.1"
                     /transl_table=11
                     /translation="MTTAYPLRDRTPGPSPISVVAHRGASEDAPEHTLAAYRRAIEDGA
                     DALECDVRLTADGHLVCVHDRRVNRTSNGRGAVSALELADLAALDFGSWKEDEDGTWEA
                     PDRQHEDPERVSVLTLERLLELVSDAGRRVELAIETKHPTRWAGQVEDRLVALLARFGH
                     TKATAEAPPPVRVMSFSARSLHRVRAAAPDIPGVYLMQFLTPRHRDGRLPPGVGIAGPG
                     VRILRAHPEYVSRAHRAGHQVHVWTVNDEADVDLCERLGVDAIITNRPKQVRAQLGLG"
     misc_feature    complement(18662..18677)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.94"
                     /tool="antismash"
     gene            18669..19475
                     /locus_tag="A6A06_RS29590"
                     /old_locus_tag="A6A06_22600"
     CDS             18669..19475
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010985652.1"
                     /locus_tag="A6A06_RS29590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_22600"
                     /product="ATP-binding protein"
                     /protein_id="WP_079194439.1"
                     /transl_table=11
                     /translation="MRHRTGIGRFPVQAIGAFIPWRGAKEVSGVALMVAQEVPTASVMA
                     VPHGPSGVGSARRRMRAELLASGVQDTVVDDAVLILSELLSNSCRHARPMCVLEAPGSV
                     RGSARDAVPDAIRAAWRIDGHGQLTIAVTDGGGPTRPQPATPSVTAKGGRGLAIIRSIA
                     KEWGVEDTEGEVTVWALLTLHGLRSAFATRVDLSAELSADFSGGGLNGRANGVTPGRTS
                     GLTRTARAPEPAGEPASRLGEPAAGRRAARGPGPELTLVECDRSAG"
     misc_feature    complement(19625..19639)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 24.85"
                     /tool="antismash"
     misc_feature    complement(19817..19832)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.9"
                     /tool="antismash"
     gene            20083..21051
                     /locus_tag="A6A06_RS29595"
                     /old_locus_tag="A6A06_22605"
     CDS             20083..21051
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006133994.1"
                     /locus_tag="A6A06_RS29595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_22605"
                     /product="DUF5926 family protein"
                     /protein_id="WP_073765190.1"
                     /transl_table=11
                     /translation="MAKKRRPQTKAAAPQIKDGEVPVVGAREPCPCGSGRRYKACHGRT
                     AAHAATELVQRPFEGLPRECDWVALRELVPAATVELTLKDGLPEGVPSVTLATVLPMAW
                     PALRRDNGAVLLGLQNDTASGDLSRDLADTLRRALAAEPGTPVAAERAAADGPRLQDLL
                     DPAAPFEPQVHSGFEFWVEDAENATGEVAASLERANAAAIPTARLDGLEGAYWCETPEK
                     NHLRWVMAHPEEQLLDALARLHAAGTSSLGEGTRLVGSFRAHGLVVPVWDLPSGTGADD
                     VAKPAAAFAERLAAALASDAPLTPEERRARGGLTNRQVTLS"
     gene            complement(21551..22180)
                     /locus_tag="A6A06_RS29600"
                     /old_locus_tag="A6A06_22610"
     CDS             complement(21551..22180)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018542570.1"
                     /locus_tag="A6A06_RS29600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_22610"
                     /product="hypothetical protein"
                     /protein_id="WP_073765192.1"
                     /transl_table=11
                     /translation="MERAPNLRMIALASTVALAVALPLAAATAGPAESERSAADDSASA
                     THPDVNVPVRAGSYAAPGPSRGAHPAPRAGTAAAPVGAGRPAASDGRRAARCGPELASP
                     EGVEAQTCVLTEGGRTWGRTYYRNTSGEPLRAVLTLMGPDGRTVQAHCELPAGDEPGTC
                     ESPREATTGGVRAPYAAVAEVADVRGERKLLRSGSNPAPGQGGSDR"
     gene            complement(22490..23209)
                     /locus_tag="A6A06_RS29605"
                     /old_locus_tag="A6A06_22615"
     CDS             complement(22490..23209)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018093455.1"
                     /locus_tag="A6A06_RS29605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_22615"
                     /product="bifunctional DNA primase/polymerase"
                     /protein_id="WP_073765194.1"
                     /transl_table=11
                     /translation="MREILGRRRKLQLRRSGRSALLGAALHCATEWQWPVLPGVGLRTG
                     GKQAGGKPPGGRGRAERGTRPCSCPDPDCVVPGAHPFDPGLFAATTDARMVRWWWTNRP
                     TAPVLLATGGRAPCALSLPAVAGARALAALDHFGVRTGPVVATPTRWSLLVAPYSLAEL
                     GELLHSRDWVPSSLRFHSEGGYVVLPPSQIGAGKVHWERSPGTGPAAPWLPQVETIVDA
                     LVTASTSAPDGGSRLAY"
     misc_feature    23413..23430
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 20.42"
                     /tool="antismash"
ORIGIN
        1 gcactacgcg cgccctgcac caggaaatca ggagtctcgc tcagtacggt cgtggcagcc
       61 tgggggtatg gggacgatgg tgggaacggt gaccacgctg tggcggtatc cggtgaaatc
      121 gctgctgggt gaggaggttc cggatatttc agcgaacgcc cacgggctgg cgggggaccg
      181 tgcgctcgcg ttggtgcatc agacgtccgg ccaggtcgcc agcgcgaaga acccacggct
      241 gtggcgcgac ttgctgaagt tgcgggccga gatcatcgac ggtgccgtac ggatcacgct
      301 gccgtccggc cggaccgtac ggtccaccga cgcgcacgtg caccggacgc tcaccgcgca
      361 cctcgggcag cccgtcaccc tcgccgacac cccgcccgag aaggccaccc tggaacgctc
      421 ctgccccgaa gaggtactgg ccgccggcac ggcggccgag gtggcgcgcg agacgatgga
      481 gatcgccaca caggccccgc ccggcacctt cttcgactac gcgccgctgc acctgatcac
      541 ccgcgccacc ctcgaccgga tcaccgaact cggcccccgg gccaccaccg tcgaggccga
      601 gcgctaccgc cccaacgtcg tgatccgcac cgaggccgcc ggtttcgtcg agaatgactg
      661 gcccggccgc gagctgcgca tcggcgacga gctcaccctc cgggtggtgg ccaggacgcc
      721 gcggtgcgcc gtaccgacgc tggagcacgg caggctgccg cgcgacccgg acgcgctgcg
      781 ggtgcccgcg cgccacaacc gggtggtgcc gatggacgac gcggacccgc agccctgtgg
      841 gggcgtctac gcgcaggtcg tacggccggg acggatccgg cagggcgacg cggtacgggt
      901 ggtgtgaggg cgcaccgggg attacgccgc gacggacagt tccgggtcct cgcgcagctt
      961 ggccagggcc cgggagaccg cgctcttgac cgtaccgacg gagaccccga gcacctccgc
     1021 ggtctgcgcc tcgctcaggt cctcgtaata gcggagcacg accatggccc gctgccgcgc
     1081 cggcagccgc agcaccgccc gccacatcgc gtcccgcagc acctgggcct cggccgggtc
     1141 gggcgccggg tccgggtcgg gctccggtat ctcctcgcag gcgaactcgt cgaccttgcg
     1201 tttgcgccac tgcgaggtgc gggtgttcag cagggcgcgg cgcacatagc cgtcgagcgc
     1261 gcggtggtcc tcgatccgct cccacgccac gaacgtcttc gccagcgcgg tctgcagcag
     1321 gtcctcggcg tcgctcgggt tggcggtgag cgagcgggcg gtccgcagca gcaccggccc
     1381 gcgggcccgt acgtacgacg agaacgacgg gaacacagcg gcgcgggagg cgctggtgca
     1441 cactggcgtg gtcatggtcc aacgctagaa gcgcggggca ccgtgacgga tcggccccag
     1501 gtgccgaaga cccctccccc tcaggttgta cgggtggggt tgcccccacc tcctaaaggc
     1561 ggacggccac tcatctcccg tcagggtcgc gcaccgactt tcgtcgggcc ccggccctca
     1621 ggtgccgggg ccccgccgcg gcgcgcgcgc ctcaaccgta gctactcgat cacggcgacc
     1681 ggtgcgtcca cctggttgcg gtcgatgacc agcctgcgcc cgccgtgcga ctcggcgacg
     1741 ttgcccgcgt actggtggat ccgccggtgc ggacgccacg ccttgccgga cagctccggc
     1801 tcgccgtaca ggttcggctt ggagtgccag cgtgcgaacc acatcaccga cggcaggtcc
     1861 tgggcaccgg cctgccgcgc ccgctccatg tgccgtacgc cggagtcggc gctgctgtag
     1921 aagccgggca catagccctg gcggctggtc tcccggttcc aggcgcggat gtagtcgagt
     1981 gtcttacggg tgcagggcgc gttgcgcagg ctgtacgcct ccatgtccag gtacagcgcg
     2041 ctgtccgggg cgatgcccag cgccttggcc cggcgcaccg cgtcccgcgc ctcgctcgcg
     2101 cccacctgcg cggggtcgcc gccgatggtc gccttgcgct tgctcttgtt gacgacgcag
     2161 ggcgcctgcg agccgacgta cagcggcagc atccgccagc ccgcgcggtg ggcggcgcgt
     2221 acccagccgg gtgtcaggtt cggctggctg gggcaggccc ggccgcgccc gccgaagtag
     2281 atgccgatgc cgcggtactt ggagcccttc caggcctgca gggtgctctg cggaggcgcc
     2341 ttgcaggtgt cgaacgccca gccccggaac acgttcgggc cgcgtggacc ggtccggtcg
     2401 ggctccgcgc cggcggccgg ggcgaggacg gtggccagca gaccgagcag gccggtcagg
     2461 gccgtgagca gggcagcggg gcgcggggca cggcgtcgga tgatcctttt tgtcgatccc
     2521 atacccggag tcaaagtgcg ggtacggggc gccgcgcgcc ggacacgcca gcggccgcac
     2581 gcattcagcc tcctgggtga tcctgcgttt cggcgttcga agagcctttc cccggggcag
     2641 ctcctggggc cttcctccgg cgggccaccg gcacccggcc cgcgccaccc cgcctccgct
     2701 cagccgtccg ccccgagcac cagcccggag gtcggtacgc ccgtaccggc ggtgaccagg
     2761 acgcccgccg cgcccggcac ctggttgacg gaggtgccgc ggagctgccg taccgcctcc
     2821 gcgatcccgt tcatcccgtg cagatacgcc tcgcccagct ggccgccgtg cgtgttgatc
     2881 ggcagtccgc ccgccgcgac gaagtccgcc gcctcgcccg gcgcgcagaa cccgaactcc
     2941 tccagctgca tcagcacgaa cggtgtgaag tggtcgtaga ggatgccgac gtcgatgtcc
     3001 gccggtcgca gcccgctcgt ccgccacagc tgccgcgcca cgacggccga ctccggcagg
     3061 ccggtcagac cgtcccggta gtagctggtc atctgctcct gggcccggcc cgcgccctgt
     3121 gccgccgccc ggatcaccgc gggcggccgt cgcaggtcac gggcccgttc ggccgaggtg
     3181 acgacgacgg cctggccgcc gtccgtctcc tggcagcagt cgagcagccg cagcggctcg
     3241 acgatccagc gggacgcggc gtggtcggcg agggtgatcg gcctgccgtg gaagtacgcg
     3301 gcggggttgc gtgcggcgta ccgccggccg acgaccgcga cctgcccgaa cgcctccggg
     3361 gtgagcccgt acgcgtacag gtagcgctgt gccgccatgg cgacccagga ggcgggcgtc
     3421 agcagtccgg cgggcaggtt ccagccgagt gccgtgccct cggcggacgg ttcacggcgc
     3481 tgcactccgg aaccgaagcg gcggcccgat cgttcattga acgcccggta gcagacgacg
     3541 acttcggcga cccccgccgc gacggcgagg gccgcctgct ggaccgttgc gcaggccgcg
     3601 ccgcccccgt agtggacgcg ggagaagaag gacagctcgc cgatgcccgc cgcctgggcg
     3661 acggtgatct cgggactggt gtccatggtg aaggtgacca tgccgtcgac gtcgccgggg
     3721 gcgagcccgg cgtcgtccag tgcggcccgt acggcctcga ccgccagctt cagctcgctg
     3781 cggccggagt ccttggagaa ctcggtggcg ccgattccgg cgatggcggc ccggccgccg
     3841 agggtgtccg cgcggcgcag gctcatggcg tgacctcctg gcccggggcc acgcggggga
     3901 cgtcggcggg ggcggagacg gaggcggcgg cgggggctgg ggctggggct ggggctgcgg
     3961 ggacggtgac ggtcaccgtg ccggtgacgt ggtggcccag gcggttggtg cccacgacgc
     4021 gcacctccgc cgtgtcaccg tccacggcga ggacgtcacc gcgtaactcc aggacgtcgt
     4081 ccgggtaatt gggcacgccg agccggatcg cgaccttgcg gagcacggcg cgcgggccga
     4141 ggcagtcggt gatgtagcgg cccacgagac cgttcgtggt caggatgttc atgaagatgt
     4201 cgggggagcc cttggccctg gccgcctcgg cgtcgtggtg tacgtcctgg tagtcgcgcg
     4261 aagcgaccgc ccccgcgacg atcagggtgc gggtgacggg gacggtcagc gggggcagca
     4321 cgtcgccggg cctcacgcct gcctcccgcc gccgtcgaga gcggacgggt ccgtatcgcc
     4381 gccgtcgaga gcggacaggc ccgtatcgcc gtcgtcgaga gccgacggct ccgtagcgcc
     4441 gccgttgaag acgggcagca ccaggtcctc gtccacgtcc cggaactcca gctgtacggg
     4501 catcccgatg cgcacctggt ccggcgccac cccgaccacg tcggccacca tccgtacccc
     4561 ctccgccagt tcgaccagcc cgaccgcgta gggcggatcg aaggccggga agggcgggtg
     4621 gtgcagcacg acgtacgaga agaccgtgcc ggaaccggcg gcctccacgg tgtcccagcc
     4681 ctcgccgccg cagctgttgc atcccggcag ccagggaaaa cggagcgtcg cacagtccgt
     4741 gcagcgctgg atgaggagct ggtggcgggc gactccggcc cagaatccgg cgttgtcgcg
     4801 gttgatcacg gggcgggggc ggcggctcgt gccgctggtc cggggctgcg cggaggcgcc
     4861 gcgtgccggg ttcgacacca gttccggcac cggctccggc accggcaccg gctccggcac
     4921 cggctccgac tccgactccg gctgcccggc gggcgcgtac ttgaggatgc ggaagcggtg
     4981 cgttccggcc ggttcgccgt ccgcccggat gtccgtccgc gtcgtgacga agtaccccgt
     5041 acccagcttc gtcgtcttgc gcggggagac cgactcgatg acggcgtcga aggtgacgcg
     5101 gtcgccgggg cgcagcgggc gcaggtattc ctgctcgcag tcggtcgcga cgacggatgt
     5161 gcagcccgcc tcgtccagca ggccgaagag cgtgtcgtac gccggtgagc ggccggggtg
     5221 tccggagagg ccgcccatcg tccacgcctg gagcatggtg ggcggggcga cggcgccggg
     5281 gccccggtac gcggggccgg tgtcgcccag ggcctcgcac cagtggcgga tcatcggctc
     5341 gttgacgggg tccttgccct cgccgcccgt cacggcggcc tgcccttcga aggccttcag
     5401 ccgtacgtac agctcgtcct ccgccagttc gtcctctgcc agctcgctct ccgcgacgcc
     5461 cgcgcctccg tccacgtacc cggctcctcc cacccgcccg tccccctcgg cctgcctgcc
     5521 gctctgcccc cgccttacgg ctccagggca acgcacggaa ggttcctgac tgtccgtcag
     5581 gaaccttccg aagtcaaggg cgcaccggca ccggccgggc gaggtcaccg gtcacgacgg
     5641 tcacccaccc cggccacccg cgccggtcgg cccgcgcccg tcggctcgcg ccggtcggcc
     5701 cgccccggtc gtcgcccggt cggctcacca gagattggcg aagttcaccg tggcgtcggt
     5761 ctggtcgatg tgggtcagcc cgtggccgtt cacgctcgcc gtgttgttct ggttcgacgc
     5821 gccggggccg ttcgcgacct gctgggtggt ggtcgagttg ccgttgttgt tgtggcccac
     5881 gccggtgccg gcctggctcg tggccgccgc gctcgacccg ttgcccgcca gtccgccgtt
     5941 gtcggcgtgc gccactccgg cgaggagggc cgcggcgagg ggcagtgcgg cgagggcggt
     6001 gagggcgcga gtggtacgta cgtttgccat gacgtttctc ctcttacggg gcgcacccgc
     6061 acgaccccca cgacgggacc ggcgggcacg gcaacactga cttccggact gcggcgcgcg
     6121 gcggggagaa gcaggggcgc ccccgctcca actccgccga actgccgcac ctcacggggc
     6181 agttgctgtc cgccctgcga ggttgacgac gtcgcggtga tcagacttgc ccaccgcgac
     6241 ccccatgaac cagaccggaa cggccacttc cccctcaagc atgaagaacc ccgggtaaac
     6301 ctcccttgcg cccccggagc gccagcgcac gcccgcgtac ccgccactcc ccttcctcac
     6361 ctgcatgaat cgttcccgca cctttccagc cgttccggaa cgagggccgt gcgccccttt
     6421 tcttaatcga acgcacatac gaaactggag acatggcctc tccccacacc gccgccaccg
     6481 acaccgccac cggaagccat ccctcccacc ccggcgacca cgccacggcc ctcacccacg
     6541 cgctcgtcgc ggccggccgc ggctactccg tcatcccgct gacccgcgcc aaactccccg
     6601 ccgtccgctc cccgcaccac gccgaccggg cccccgcccc ctgccgcggc gcctgcggcc
     6661 gccccggcca cggcatccac gacgcgaccc gggacccgct cgccgtccgc cacctcttcg
     6721 cggccgcgcc ctgggccacc gcgtacggca tcgcctgcgg cgtccccccg caccacctca
     6781 tcggcatcga cctggacacc aaacacagcg cggacggcct caccgccctc caactcctcg
     6841 ccggggaaca ccgcttcacg ctgccgccca ccctcacggt ccacaccccc agcggcggcc
     6901 gccacctcta cctctccggc ccgccgtccc cgtccgtacc caactccgcg ggccgcctgg
     6961 ccccgggcat cgacatccgc ggcgccggcg gctacctggt cggccccggc tcccgcacct
     7021 cccgcggccg ctaccgcccg gcctccggcg tcccccggtc ccccgccccg gccccgcccg
     7081 cgctcctcac cctcctcgcc cagctcccgc ccaccaccca ccaccccaag acgtcgccgg
     7141 ttcccgcggc ccaccccgcc cccgccctgc tccgcttcgt ccgcacctcc cccgacggcc
     7201 agcgcaacgc gcgcctcttc tgggcagcct gccgcgccta cgcatccggg atcggccagg
     7261 agatggccac cgccctcacc accgccgccc tcgacaccgg cctcaccgag cgcgaggcgc
     7321 gcgccaccat cgcgtcagcc gcccggcgtt gactccggca cccggccgac cgcaggagtg
     7381 gcatccgcgg gacttcaggg tgtcgtcccg ccacgttcgg ccgattgctg gtcaactggc
     7441 agtcagcacc gcacgggacg gagagggcga tggacccaga ccggctggcc gactcgtaca
     7501 gcgacaccaa ccccttcttc cggctgttcc ggcacatggg ctggggcgca ctggtcaacc
     7561 tcggttacta cacgatcccc accctgccgg cgctcctcgg cggcgtcgcc ttcttccagc
     7621 gccgactgga gacgcggtgt ctggagctgt tgcaggcccg ccccgggcac cgggtgctgg
     7681 acgcctgctg cggacgcggt cacaccaccg cccgcctggg ggccgcgggc tgctccgcgg
     7741 tcggtgtgga catcagcggg cagcagatcg cccaggcccg cagccggtac ggcgccgccc
     7801 cgaacaccgc cttcgccgtg gccgacgtca ccgcgctgcc cggtcaggcg tccggcttcc
     7861 cggtggcgga ccgcccgttc gaccggatcc actgcctcga agccgccttc cacctctccc
     7921 ccgccggccg ccgcgccctc ctggccgagg ccttccgggt gctgcgcccc ggcggacggc
     7981 tcgtcctggt cgacttcacc tggcgtaccg cggatccgga caccatccac gggctcgacc
     8041 cgcggggcct gctccgcgcg gcctggcaga tcgaagggtt cgagccgctg acccgctacc
     8101 tggtgcacgc ggaggcagcg gggttccggg tgtcgcgcac ggtcgactgg accagacccg
     8161 tcgtcgagcg gtccctgcgc ctgggggcgg tcctgagccg gatggcggcg tcccggggcg
     8221 gccgtgaggt gctggggctg cgctgggccg ggctgcgcga gttcaccgag caggactggc
     8281 agaccaccat cgccaccatc gacgcccacc agtcggtggg gcgcggtgtc ggctactccg
     8341 ccctggtgct cgacaagccg ggggccgagg ggggccgcgc gcggtgacgt cccgtcgttc
     8401 tccctctcag gagcaggtcc cggcccagga gcacgccgct tctcagcctc aggagcacac
     8461 cgcctctcag gagcatgctg cctcccaaga gcaagctgcc gctaaggagc acgccgcggc
     8521 agccgtacag gcggagtgtc cgctgcggct gcggatcagc ggcgtgtgga agggctacgg
     8581 ccgcagggag gtcctgcgcg gcgccgacct ctcggtgccc gcgggggcgc tggtgggcgt
     8641 ggtcggtgag aacggggccg gcaagagcac cctgctgcgg ctcgcggtcg gtgaactggc
     8701 cccggaccgc ggaacggtgg cgcgcaccgc gtcggtgggc tactgcccgc agcgcgcggt
     8761 gctgaacgac acgctcaccg taggccagca cctgcgcctg ttccggacgg cgtaccggct
     8821 gccggacctg gaccgggccg gcgagctgat ggacctcctg gcgttcaccg gctgccggga
     8881 ccagcaggcc gggagcctga gcggcggtac gcggcagaag ctcaacctgc tgctcgccct
     8941 gatgcacgac ccggacctgc tggtgctgga cgagccgtac caagggttcg actgggacac
     9001 ccaccagcgt ttctggagac tggccggccg gctgcgggac aaggggcggt cgatcgtggt
     9061 ggtctcccac ctcctgcacg acctggagca ttttgacgcc gtgggccgac tgcgggaggg
     9121 ccgtatcgag agcgaggggc accactgatg ggtcaccggt gggcggcgtt caccgagatg
     9181 ctgcgctgct cgctgctggg gcatctgcgc aaccggctgg cgatggtcct ggcctgcgtg
     9241 ttcgttccgg tgtggatcat cgtcgggcgc gtatgcgcgc tcgatacggt ggtgcgctac
     9301 cgcctcgaca tcctcgacgt ggacgccgtc ggcctcgcga accgggtcgg gcaggtgtcc
     9361 aacgccctgt ccgccatcat gctgatcacc ggcttcatga tgttcacgga gacgttcaag
     9421 gccggggaga tggaccggcg tctcgtgctg gccggttact cccgcctccc gctcctgctg
     9481 gcgaaggtcg ccgcgctctt cgtggtcgcc tcggtgctgg ccggctacac cgtcgtctgg
     9541 ctgagcctgt tcctccccgt ggagcagttc tggcccctgg tcctcgccct cctcgccgcc
     9601 gggctcgcct acggcggcat cggcctcctg ctgggttccc tcgtacgcgg tgagttggag
     9661 ggcttcttca ccgtcgtgat gctcagcctg atcgattccg gggtgcagaa cccggccctc
     9721 gaagcggcga acctgcccgg cctgagcgtc ctgccgtcgt acggcgccgc ccagtcggcg
     9781 ctggccgcgt ccttcacccg gaccggcccc ggtgcccacc ccctgctggc cgtcgcctgg
     9841 tgcgccgcga ccctggcgct cacgctgctc gtcttccacg tccgtacccg ctcctaccgg
     9901 accggtaccg gttccctggc ggcccgtgcc ggcgcggaag ccgtcgcccg gtgcccggcg
     9961 gcgtgagtgc ggccgcccgc ggacgcgtgc gccgcccgcc tcacgcgatg cggttgacct
    10021 ggacgacgtg ccgggccatg tcgagcagca tccgggtgcc cggcacctgc ggcagcatcg
    10081 gctccagccg gctccaggtc tccgccacca gcgactgggc ctcccggacg caggcctcca
    10141 gggcgccgca gtcgcgcagc tcggcggccg cgcccaggac cgtggtgcgg tcggcccggc
    10201 cgtcccgtac ggcgtgccac agcggggcga gacgcctacg ggggagccgg gcgacggcgt
    10261 gcgccagcgg catggtgacc ttcccgttgt ggaggtcctc accgacctgc ttcgtcacca
    10321 ccccgtcgcg taccacccct tccaggtccg cgacgtcgtc ggtgatctgg tacgccgtgc
    10381 cgatggcgga gccgaacgcg accagggcgg tgcgctgccg gtcgtcgaca ccgcacacga
    10441 gcgcggcggc ctccagcccg gcgcccacca tggccccgga tttcaggcgg tgcgtcaggc
    10501 gtacggcttc gagcgccggc tcggcgtcct cggtacggac cgcctggtcc atctcggtgc
    10561 ggtgcccctg gatgtccagc gcctggcccg cgtgcgcggc gcgcagggcc gccaggtacg
    10621 cgtcgtagag gcgggcccgc agcaccaggt cctccgggac ggtcagccgg accgcccggt
    10681 ccagcgtgaa ataggcgaag gtgcccgcgt tgagggccgt ggaggtgccg aaggcggtgt
    10741 gcaccgtggc ccggccgcgg cgcagcgacg cgccgtcctc cacgtcgtcg accatcaggg
    10801 aaccggtgtg cgccagctcc atcgaggcga ccagcgggcc gaagtgctcg ctgtccccgc
    10861 cgagcacttc gatcaccgcc atcatcaggc cggggcgcca gcgcccgccg cccgcgccga
    10921 ccaggtagcg caccggttcc gtcagggcgg cgtgcagccg gccgccgacg cgggcgtgcg
    10981 cggggtcgcc ggagcagtcc gtcggctcgc cgccgcagtc gtacgccatc agcggtgacc
    11041 cggcgtcgcg gcagcccgcg ggggtgccgg ggtagagacg ttcgatctgt gcgtcgaccc
    11101 gtccggccca acgggcaagg agttcctgaa acgtttcttc ttcggccgcc ggcctgctcg
    11161 ccggtctttc cgcgggaagt tttgtggtgg gagtggatgt cacatgactg ttctaccgat
    11221 ggtcgtgccg attcgcctgc gcagcgatac cggcgagcgg gtgacacaaa caccgcccgc
    11281 tctgctgaat gcgtgacgcc gggtcgtttc ccggggcgtg tccggccggt gcgctaacgt
    11341 gacgcgcaca tcaccccatt tacccccttc ggcccttccg cgcgagcccg cacccgttct
    11401 ttccgcaccg gctacaccca ggggaatcca tgaccacgac gaccgatgac gaatcccgcc
    11461 cggacgggac gctgtccagc acgccggacc cggctccgac cttcgctttt ccgccgtccg
    11521 acgaggtcga ggaagcggcc cggcaggccg cactgaaggc cgcggacaac ctgctggccc
    11581 ggcagcaccc ggacgggtac tggcgggaat tcctcggggt gaataccagc atggacgcgc
    11641 aggattcact gatgcgccaa ttcctgggca ttctggatga ccggaccgcc gcggcgaccg
    11701 gccggtggat tcgttcgaag cagctaccgg acggttcctg gtcccccgtt cacgaaggcg
    11761 ccggtgatct gggcatcacc atcgagtcct atctggctct ccggctcgcc gggcacgacc
    11821 cggacgaacc gcatatgcgc caatgcgcgg aatgggtacg cgaaaggggc ggtctcgcgg
    11881 ccgcccgggt gacgacgcgc atctggtgcg cgatgttcgg ctggtggagc tgggaccggc
    11941 tgtacgaggt accgcccgag atgatcctgc tgcccaagtg ggccccgctg aacgtctact
    12001 cgtacctcta ctggatgcgc caggtcgtcg tcccgtacct cgtcgtcctg tcccaccgcc
    12061 cggtggcacc ggtgccgttc ggcatcgacg agctgctggc cgtccccggc acccacgcgg
    12121 gaacgcggac cgacgggccg tccggcgggt gggacggcgt cttccggggc ctgaaccgcg
    12181 ccctgcgctg gtaccgcaag gccggcccgt cctcggtgcg ccgggccgcg gtcaacgcct
    12241 gcctccgctg gatcaccgaa cgccaggaag cggacggcag ctggggaggc gtccgggtgc
    12301 agaccatgtg gtcggtgttc gccctgcgcc actccggcta cccgctcgac cacccggccg
    12361 tcagggccgg actcggcttt ctggaccaca ccatcgtctg gcccgaggag ggcgtacgga
    12421 aggtggagat ctgcgagtcc ccggtctggg acaccgcgct gtccgtcatc gcgctccggg
    12481 acaccgggct gccgggcgac cacccggccc tggtcagggc cgccgactgg ctggtcggcc
    12541 agcagacgac acgacgcgcc gactggtccg tgcagcgccc ccggctcgct accggcggct
    12601 gggcgttcca gttccacaac gagtgctacc ccgacatgga cgacacctcc gaggtggtcc
    12661 tcgcactgca ccgcgtccgc cacccggacc ccgcgcgcgt cgacgcggca gtgcgcaagg
    12721 gcgcgcactg gaacctcggc atgcagagca agaacggcgg gtggggggcc ttcgacgcgg
    12781 acagcgtcag ccccatcccc gaacggctcg ccctcaccgg catcagcttc atcgccgacg
    12841 cgccgagcgc cgacatctcc gggcacgtgc tggagatgct gggcgcgctg gggatgcagg
    12901 acgacatccg cacccggcgc ggcatccgct ggctgctcgc ccagcaggag gacgacggct
    12961 cgtggttcgg ccgctggggg gtgaatcacg tgtacggcac cggcgccgcg gtcccggccc
    13021 tcatcgcgaa cggtgtgcct cccggccacc cggccgtccg gcgcgccgtc gcctggctcc
    13081 ggtccgtaca gaacgcggac ggcgggtggg gcgaggactg ggagtcctac accgatcccc
    13141 gctacatcgg ccacggcccg tccaccccgt cgcagacggc ctgggccctg accgcgctgc
    13201 tcgccgccgg agaacgcgac agcgaagccg tccggtccgg catccgacgg ctcgccgaca
    13261 cccagcgcga cgacggcacc tgggacgagc cgtaccacac cggcaccgtc atccccgggg
    13321 aatacgccct gcactacggc ctctacgccc acgccttccc cctcaccgcc ctcggccgct
    13381 acgtacagca ccagaacgag ggggccatcg cgggcgcccg ccctggtccc gcttgaggcc
    13441 ggggcaggcg tgaggcatgt gcgggggtga ggcaggcgtg agatcggggc cggcgcaggg
    13501 cggaatccag ccattgtcac gtcgacccgt ggcgggccgg gcgggcggaa ggaaaagacc
    13561 cccgtgatca aaaaagaggt ggtttgccac cccggaccat gaactacggg cggctcggcg
    13621 agccctttcc ccgaatttcc gagcgcgggc ccccggcccg atcctggccg atagcggcgg
    13681 ctacgcacgt gacaaccgtc gctctgtgtt agtgcgctgc gttaccgtca cgcacggagc
    13741 aggcgcacca gccttggggg gcagcacatg gccacggtca aaacgctcac atgtttggcg
    13801 aactcccgca agcatgcggg ccgatgtgtc gcaggcatgg ccgacgacgg ttccgggcaa
    13861 tggatacgcc cggtgagcaa ccgctccacc cacgaggtat ccgaacacga acggcaatac
    13921 gccgacggat cggacccgaa agtcctcgac atcatctccg tgccgctcct ccgccctcag
    13981 ccacacggct tccagagcga gaactggctc ctcgatcccg aatactactg ggagaagacc
    14041 ggccgggccg ggtggggcag cctgctgaag ctggagcagc atccgaacac cttatggacg
    14101 aacgggaaca gcacttacca cggctgcaac aaccgcgtca cagccgacca ggcagacgct
    14161 ttaccggact cactcaagct catacgcgtc gaccgcgtga cgttacaggt gcacgtcccg
    14221 ggcgcagcgt tcaacgaccc caaacgggcc gtggacgcac atttccacca cgccgactgc
    14281 aagtacatcc tgcgagtgac cgatcccgaa tacgaacaga cctacctggc cagatccgac
    14341 ggaatctaca gactgaacga atccttcctt tcggtgagcc tcagcgaacc acatgaaggt
    14401 tatgcttaca aattagtggc agccatcatc gagcgagcga aaatctaagc aggcagcaag
    14461 caatgacacc acccaccgca ttcacagtcg gccactccac gcacagcgtt tcacatttcc
    14521 tgagcctgct gcagaagcat gagatcacgg cggtcgccga tgtacggtcg acgcccgcca
    14581 gccggttcac accccagttc aaccgggacg cgctgaagcg cagcctgagt gacgccgaca
    14641 tcaagtacgt cttcctcggc gacgaactcg gagcgcgcac gagagacacc acttgctatg
    14701 tcgacgggcg ggtacagtac agccgcctcg ccgagacgcc cgatttcatc agcggcatcg
    14761 accgtttaca aaacggcgcc cagaccgagc gcatcgccat catgtgcacg gaacaggaac
    14821 cgctcgactg ccatcgctgc gtactcgtcg cacggacgct cgaagagcgc ggaaccgcca
    14881 tcgcccacat tcacggggac ggccacatcg agagccacac catggccatg caacgcctgc
    14941 tggccggctt cggcctggac caggccgaac tgttccgcac accggccgaa cgcctccagg
    15001 aggccctcag ccgccaggaa cagcgcatcg cctacgtcga cgaggagctt cgcatcaacg
    15061 ggacgccgga aaaatgaaac tgcacaccat cggcttcacg aagaagtccg ccgaaaaatt
    15121 cttcggacta ctgaaagaag ccggagtgac cacgctggtc gacgtccggc tcaacaacgt
    15181 ctcgcaatta tccggcttcg ccaagcgcga cgacctgaag tacttcctcg gcgagatctg
    15241 cggcgcgcaa tacgcccacc gcatcgacct ggcgccgacc cacgacatgc tcgacgacta
    15301 caagaagcga cgcgtcgact gggcaaccta cgaagaacaa ttcgtggaac tgataaagaa
    15361 tcgccgcatc gaggacaccg tcccgcggga acttctcgac aacgcggtcc tgctgtgcag
    15421 cgaacccacc gcacaccact gccaccgccg actggtggcg gaacacctcg cacagcaatg
    15481 gggcgacgtc acggtcagcc atctgacatg aggccccgaa gagccgccca gcccacgcaa
    15541 gaggggcgcc cgatccgctc ggacgcccct tctgaccagc ttgtctgctg acctgggcgg
    15601 aggctgtggg atttgaaccc acggtgaggg gttacctcac gacagttttc aagactgttc
    15661 ccttaggccg ctcgggcaag cctccccgcg cgccggtgga cggtgcgcgg ggatcagact
    15721 agcgcgtcac ttgtcgcccg tgcgctggcc cagggtcacc tgggtggtga gctccttgcc
    15781 gccgcgcttg taggtgagcg tcaccttgtc gcccggcttg tgctggtaga tggtgctgat
    15841 cagggtgggg ccgctgtcga tgacggtgtt gtccagcttg gtgatcgtgt cgccgggctt
    15901 caggccggcc ttgtcggccg ggccgttcgg ggtgatcgag gcggagccgc cggcgccgcc
    15961 gtcctgggcg atggtcgcgc cgtcgccggt gtcgcgcatc aggacctgcg cgccgatctg
    16021 cgggtagacc ggctggccct tcctgatcag gtcgtcggcg acccgcttgg cctggtcgat
    16081 cgggatggcg aagccgaggc cgatgctgcc ggactggctc tcgccgccga aaccgccgcc
    16141 gccgttgccc gcggactgga tggccgagtt gatgccgatg acgctgccgg aggcgtccat
    16201 cagggggccg ccggagttgc ccgggttgat cgaggcgtcc gtctgcaggg cgctcatgta
    16261 cgagggggtg gcgttgccgc cgtcgctgga ggccaccggg cggttcttgg cgctgatgat
    16321 gccggtggtg accgtgccgg agaggccgaa gggcgcgccg atggcgatcg tcgcgtcgcc
    16381 gacctggacg ttggcggact tgccgagcgg gagcgggacg aggttggcgt cggaggggtt
    16441 cttcagcttg atgacggcga cgtcgtagcc ctgggcccgg ccgatgacct cggcggcgta
    16501 cttcttgccg ttggagaacg tcgcggtcag tttgccgccc tgggcggcgc tggccacgac
    16561 gtggttgttg gtgaggatgt ggccctgctt gtcgtagacg aagccggtgc cggtgccgcc
    16621 ctcgccggtc gcgccctgcg cctcgatcgt cacgacgctg ggcagcgcct tctgcgctat
    16681 gccggagacg gaggtgggct tgcggttgag cgcctcgggg tcgccggagg cggagaccgt
    16741 cgtcgagttc gcgtcgtcgc ggccggcggc ccagaagccg atgccgccgc cgatgccgcc
    16801 ggccaccagc gcggcgacga gcacggcggc gatcaggccg ccgttgcggc gcttcttcgg
    16861 cgcgggcgcg cccggggcgc cccacacgcc gtccgggccg cccgcgccgc cgcctccgta
    16921 tccgggcggg gggctgcccc agccgccgcc ggaggcgccg tgcgccgccg tcgcgtacga
    16981 gggcggcgtg gtcgggtggg aaggggcgcc ctcgccgtgc tgggcgcccg ggtaggactc
    17041 ggcgcccggg taggactggg cgtccgcgta cggctgcggc tgaggggccg tgtgcggctg
    17101 ggaagccgtg tgcgggccgc ctgccgggtg ggggtgatcc tgcggttcct gcggggcctg
    17161 cgggccggtc ggcttcgaga actgctgcgt acggtcggag gtgccggccg gggtgccgtc
    17221 cgccgggccc gcctggccgg ccgtcggcgc gaactccggc ggcgggggcg cggccggcgg
    17281 ggtcgcggcg gaggcggacg atgcgcccgg ggccccggcc gccgtgtccg ctctgtccgc
    17341 tgcctgcggc gcgtccgccg cgccccgcgc acccgcgccc tccgaaggac gcgcaccgga
    17401 ctcgggtgcg ctgtccgacg cctggggcgc cgtcggcggc tgggcctccg gcgggacggc
    17461 ggcgccctcg ttctcggtgc tcacggctct ctcctcagct tcgcgacggt gccgggccac
    17521 ggcccggcct ctccttcagg atgcggttcg gtgtccagga tgcggtgtag caacctggcg
    17581 tacgggcgac gggcaggcag taccggcgac tgtcacaggt gccagccttt cccaccgcgc
    17641 gtcaggtcgc cgtaagccga ggctgtgact gtctccccat cctttatgtc ggacaaaaac
    17701 ggcgcatctg gtgttatgcg gatcaggtag tgcacaaggc gaccctcccg cgggcgatgg
    17761 cacgataacc cggtgaccac cgcgtacccg ctccgggacc gcaccccggg cccttccccc
    17821 atttccgtcg tagcccatcg tggcgcgtcc gaggacgcgc cggaacacac tctggccgct
    17881 tatcgccggg cgatcgagga cggcgccgac gcgctggagt gcgatgtgcg gctcaccgcc
    17941 gacggccatc tcgtctgcgt gcacgaccgc cgggtcaacc gcacttccaa cgggcgcggc
    18001 gcggtctccg ccctggagct cgccgacctg gccgcgctgg acttcggctc ctggaaggag
    18061 gacgaggacg ggacctggga ggcgccggac cgccagcacg aggacccgga acgcgtctcc
    18121 gtcctgaccc tggagcgact tctcgaactc gtgtccgatg cgggccgccg tgtcgagctg
    18181 gccatcgaga cgaagcaccc cacccgctgg gccggtcagg tggaggaccg gctggtcgcc
    18241 ctactggcca gattcggcca caccaaggcc acggccgagg ccccgccgcc ggtccgcgtc
    18301 atgagtttct cggcccggtc gctgcaccgg gtgcgggccg cggcccccga catccctggt
    18361 gtgtacctga tgcagttcct gacgccgcgc caccgcgacg ggcggctgcc gcccggtgtg
    18421 ggcatcgcgg gacccggcgt ccggatcctg cgcgcgcatc ccgagtacgt gtccagggcg
    18481 caccgcgcgg gccaccaggt gcacgtctgg accgtcaacg atgaggcgga tgtcgacctg
    18541 tgtgaacgcc tgggagtgga cgcaatcatt acgaaccgcc ccaaacaggt acgagcccaa
    18601 ctcggtctgg ggtaacggtc gtgacgggga gtgcaccggc gcattcgacc cgtattcgat
    18661 cgtgacgagt gcgtcaccgc accgggattg gccggtttcc ggtccaggcc attggggcat
    18721 tcatcccgtg gcgtggggcg aaggaggtct cgggggtggc gttgatggtg gcacaagagg
    18781 tgccgacggc gtcggtcatg gccgtacccc atggtccgtc aggggtcggg tcggccaggc
    18841 ggcgtatgcg tgccgagctg ctggcaagcg gcgttcagga cacggtcgtc gacgatgcgg
    18901 tactcattct ttccgaactg ctgagcaatt cctgccggca cgcacgcccg atgtgcgtgc
    18961 tggaggcacc aggttccgta cgcggctccg cccgcgacgc ggtgccggac gcgatacgcg
    19021 ccgcatggcg catcgacgga cacggccagt tgaccatcgc ggtcaccgac ggcggcggtc
    19081 cgacccggcc acaaccagcc actccgtcgg tcaccgccaa gggcggccgc gggctggcga
    19141 tcatccggtc catcgccaag gaatggggcg tggaggacac ggagggtgag gtcacggtct
    19201 gggccctgct caccctccac ggactccgca gcgcgttcgc tacgcgcgtt gacctctccg
    19261 cggagctgtc cgccgacttc tccggcggcg ggctcaacgg gcgggcgaac ggcgtcaccc
    19321 cggggcgcac ctccggcctg acgcggaccg cccgagcgcc ggagcccgcc ggggaaccgg
    19381 cctcccgcct cggcgaaccg gcggccgggc ggcgcgcggc ccgcggaccg gggccggagc
    19441 tgacactggt ggagtgcgac cgctcggccg gctgaggaca cgggcatgcc ggcgcctgag
    19501 gcggtcgggc gggtcagcgc ggcggtcgaa tcgacggcgg ccagggggac ggctgctcgc
    19561 tcggagggac ggccgttcgc ccggagagac ggctgctcgc tcggagggcc ggctgctcgc
    19621 tcggagggac ggtcggaccg acggccgcca gggctgcggt cggtccggtc agcgcggcgg
    19681 tcggccgacg gccgccaggc cggggacgcc acgccaggcc gggcacgcca ggcacgccgg
    19741 acaccggggg ccggggccgg gccggtcagg gcgcagcaac ggcgcgtccg ggcgggctac
    19801 gcgctcagcg ggcgcccgta cgctcccggc gtacccccgc cgtccggtcc gccgacacgg
    19861 ccgtacggcg acgagcggtc gcgcgggacc aattccggcg gcccgcccgg tcgcggacgg
    19921 tggacgggcc gtccgaggac ggcgggcggc acaccgcgtc ctccgcttcc ccggcggtac
    19981 gcggccaccg gccgcagcgc tcggcgcagg gcgggcacag tcgtctaggc tcgcgccgga
    20041 acgcgtccgt acgcccagga acgaccagga gaaagcctcg ccatggccaa gaagcgccgt
    20101 ccccagacca aggccgcagc accgcagatc aaggacggcg aggtgcccgt cgtcggagcg
    20161 cgcgagccct gcccctgcgg ctccggccgc cgctacaagg cgtgccacgg ccggaccgcg
    20221 gcgcacgccg cgaccgagct ggtgcagcgc cccttcgagg gcctcccgcg cgagtgcgac
    20281 tgggtggcac tgcgcgagct ggtgcccgcc gccacggtcg agttgacgct caaggacgga
    20341 ctgcccgagg gcgtgccctc ggtgacactg gcgaccgtcc tgcccatggc atggccggcg
    20401 ctgcgccgcg acaacggcgc cgtcctgctc ggcctgcaga acgacaccgc ttcgggtgac
    20461 ctcagccgcg atctcgccga cacgctgcgc cgcgcgctgg ccgccgagcc gggcacgccg
    20521 gtcgccgccg agcgcgccgc cgcggacggt ccgcgtcttc aggacctgct ggacccggcc
    20581 gcgcccttcg agccccaggt gcacagcggc ttcgagttct gggtggagga cgccgagaac
    20641 gcgacgggcg aggtcgccgc ctctctggag cgggcgaacg ccgccgccat cccgaccgcg
    20701 cggctggacg gcctggaggg cgcgtactgg tgcgagacgc ccgagaagaa ccacctgcgc
    20761 tgggtgatgg cccacccgga ggagcagctg ctggacgcgc tggcccggct gcacgccgcc
    20821 ggtacgtcct cgctcggtga aggcacccgg ctggtcgggt cgttccgcgc gcacggcctg
    20881 gtcgtgccgg tctgggacct gccctccggg acgggggccg acgacgtggc caagccggcc
    20941 gccgcgttcg ccgagcggct cgccgcggcg ctcgcctcgg acgcgccgct gacgccggag
    21001 gagcgccgtg cccgcggcgg cctcaccaac cgtcaggtga cgctgagctg accgtggtcc
    21061 gtggggcgcg gatcggcccg ccgggcgtga ctccggtcac aactggacgt accgaccagt
    21121 aaatacgcgt ccggaattcc acgatcgaat ttgcgaaccg ccgatctctt gttaccgttc
    21181 taggagcccg gtcgctggtg catcccccgt cgccagcgac cgggcgcttc catgcccgcg
    21241 tccgcaggac cgagcgggcg gccccggccc cgcgagagcg ccgggagaac gccaccgggg
    21301 acaccgtccc ggcgcgaccg gcccgccaca ccccctgtga gcccgcctcc cgccacgtca
    21361 ggcccgccgc gcacattccg gcggcccact cgctgccaca gccccgtacc gggcgtcctg
    21421 gacgccgcgg gcagcccacc gccgcgccgg gcccacggca cacctcctgc cgctcccgta
    21481 ccgtcatggg tccgaaccac ccctggtcat tggtccgacc acccggggtc atcggtccga
    21541 accacccggg tcatcggtcc gaaccgccct gccccggcgc cgggttgctg ccggagcgca
    21601 gcagcttccg ctcgccccgc acgtcggcga cctccgcgac cgcggcatac ggcgcccgga
    21661 cgccgccggt cgtcgcctcg cgcggactct cgcaggtccc gggctcgtca ccggccggca
    21721 gctcgcagtg cgcctgtacg gtccggccgt ccggccccat cagggtcagg acggcgcgca
    21781 ggggctcacc ggaggtgttg cggtagtacg tacgccccca agtccgcccg ccctcggtga
    21841 gaacacacgt ctgggcttcc accccttcgg gtgatgcgag ttcgggaccg cagcgggcgg
    21901 cacggcggcc gtcggacgcg gccgggcgac cggcaccgac gggcgccgcc gcggtgcccg
    21961 cgcgcggagc cggatgcgcg ccgcgggacg ggcccggtgc cgcgtatgag cccgcccgga
    22021 ccggaacatt gacgtccgga tgtgtagcac tcgcggagtc atcggctgcc gaccgttcag
    22081 attcggccgg accggcggtc gcggcggcca gcggcagcgc gacggcgagc gcgaccgtgc
    22141 tcgccagcgc gatcatgcgg agattcggcg cacgctccat gggaccacct ggggttgtca
    22201 gggcgacgga ttgaccgccg gattgacggt gcgccgaaca tatcggcccg gaacgggcac
    22261 ataccgggcc cgtacccccg aatccccgcc aacaccgggc agctcacacc cgtacgagtg
    22321 aaccgcccgc gcgttctttg tccgcgccga gcggtgggag ggggcccggg aggggcccgg
    22381 gaggggtccg gaaggggatg cgaaggagtt cggaagggga cgcttcggtg cggccgggcg
    22441 cgacggacga cggcggggcg ccgcagcggg cgcccctcgg cccggcggtt cagtacgcga
    22501 gccggctgcc gccgtccggc gcgctggtgc tcgcggtgac cagggcgtcc acgatggttt
    22561 ccacctgcgg cagccagggc gctgccgggc cggtgcccgg cgaccgctcc cagtgcacct
    22621 tgcccgcgcc gatctgcgag ggcggcagca ccacgtaacc gccctcgctg tgaaagcgca
    22681 gcgagctggg tacccagtcc cgggagtgca gcaactcgcc cagttccgcg agggagtacg
    22741 gggcgaccag caacgaccag cgggtagggg tggcgacgac cgggccggtc cggacgccga
    22801 agtggtccag ggcggccagc gcccgcgccc cggcgacggc cggcaggctc agcgcgcagg
    22861 gcgcgcggcc gccggtggcc agcaggacgg gcgcggtcgg ccggttcgtc caccaccaac
    22921 gcaccatgcg ggcatcggtg gtggccgcga acaggccggg gtcgaagggg tgcgcgccgg
    22981 gcaccacaca gtccgggtcc gggcagctgc acgggcgcgt cccgcgctcg gcgcggccgc
    23041 gtccgccggg tggcttgccg cccgcctgtt tcccgccggt ccgcagcccg acgcccggga
    23101 gtacgggcca ctgccactcg gtggcgcagt ggagcgccgc accgagcagc gccgaccttc
    23161 cactgcgccg gagctggagc ttgcgtcgcc ttccgaggat ctcgcgcatg agcgctcgtt
    23221 cctttccgtt aacgccgagg gctgggtcca tcgcactaca tgccggttca tgccgctgcg
    23281 tggcgttacg aggtggctcc tgcgaacccc tgacgccacg tggatctctg gtcactgcct
    23341 gtacggagca gcgcatcacg ccatacgccg agcgtggaac gtggcggagg gtggcgcgcg
    23401 catggcgctt gctgtcccgt ggagcggttc cgccac
//
