LOCUS       NZ_LWKZ01000024        10987 bp    DNA     linear   CON 28-MAR-2024
DEFINITION  Streptomyces sp. CB02923 scaffold4, whole genome shotgun sequence.
ACCESSION   NZ_LWKZ01000024
VERSION     NZ_LWKZ01000024.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CB02923
  ORGANISM  Streptomyces sp. CB02923
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 1153214)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1153214)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra,H. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-APR-2016) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2016
            Assembly Method                   :: CLC NGS Cell v. 8.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905005.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:56:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,128
            CDSs (total)                      :: 8,049
            Genes (coding)                    :: 7,904
            CDSs (with protein)               :: 7,904
            Genes (RNA)                       :: 79
            rRNAs                             :: 2, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 145
            CDSs (without protein)            :: 145
            Pseudo Genes (ambiguous residues) :: 0 of 145
            Pseudo Genes (frameshifted)       :: 32 of 145
            Pseudo Genes (incomplete)         :: 128 of 145
            Pseudo Genes (internal stop)      :: 11 of 145
            Pseudo Genes (multiple problems)  :: 22 of 145
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:21:38
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1009431
            Orig. end                         :: 1020418
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LWKZ01000024.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10987
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="butyrolactone"
                     /region_number="7"
                     /rules="AfsA"
                     /tool="antismash"
     cand_cluster    1..10987
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10987
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5987](+)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5987
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
     gene            1147..2019
                     /locus_tag="A6A06_RS27615"
                     /old_locus_tag="A6A06_20660"
     CDS             1147..2019
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003981102.1"
                     /locus_tag="A6A06_RS27615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_20660"
                     /product="PaaX family transcriptional regulator C-terminal
                     domain-containing protein"
                     /protein_id="WP_073764314.1"
                     /transl_table=11
                     /translation="MSDQYAHGTPRSLIVTFYGAYGRGPAGGPGGPEGPVPVAALIRLL
                     GELGVDPPSVRSAVSRLKRRGLLVAARTESGAAAYGLSDAAHQLLDDGDRRIYGKPSPG
                     PSDGWVLAVFSVPEQERHKRHLLRSRLSRLGFGTAAPGVWIAPSHLYDETRHTLDRLQL
                     SPYVDLFTGAHAGFEPTADAVARWWDLESLAGRHRAFLKTHEPVLRHWSNRRPVPPEAA
                     YRDYLLALDAWRRLPYADPGLPSPLLPEDWPGGHAADVFGRLHARLRATGARFVRAAVG
                     EPGRAAAAT"
     gene            complement(2033..2797)
                     /locus_tag="A6A06_RS27620"
                     /old_locus_tag="A6A06_20665"
     CDS             complement(2033..2797)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003981103.1"
                     /locus_tag="A6A06_RS27620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_20665"
                     /product="HAD family hydrolase"
                     /protein_id="WP_079194374.1"
                     /sec_met_domain="HAD_2 (E-value: 2.8e-29, bitscore: 98.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRESAGAVPRPGGAARAAAGETIRAAVFDLDGTLANTLPAISRLL
                     VKVASEQGRSVTPRQAAAAIGKPPGPAFGKLLAMPEDHEAVAAAIGRYRELFAHEVLRE
                     GPRLLFPGVAAGLSALRAHGIELAVATSKGTRSAEALLDVLGIRDLLGPVISQDMVRRG
                     KPHPEMVLRAAADLGVAPWESAYVGDTVGDMRMAVTARMEPVAVTYGVGSFGELAAVAG
                     TRMCGSFKDVVSAVAAARPRPMAAAAAHQRRR"
     misc_feature    complement(2474..2476)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    2847..2860
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.56"
                     /tool="antismash"
     misc_feature    complement(3151..3168)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.13"
                     /tool="antismash"
     misc_feature    3182..3198
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.59"
                     /tool="antismash"
     gene            3221..3898
                     /locus_tag="A6A06_RS27625"
                     /old_locus_tag="A6A06_20670"
     CDS             3221..3898
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016574419.1"
                     /locus_tag="A6A06_RS27625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_20670"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_274535892.1"
                     /transl_table=11
                     /translation="MRCAHSRTRDRTDTVPTQHRAIQSRQALLRSAAEAFTEKGVPSSG
                     MVDISRRARLSKGALYFHFASKEELTFAVRNEALGALRALEDELTHAPHPAPAAVRDFA
                     IGLLGRVDTDVVVRAGLQLRPETAPGIAEPELQQRWFTLFLEKATADRAAGKLPPGDDP
                     RRSARLLSALVVGLLHLGHEDRTWWDKDVVTDIWTQLLPGGAGTAAEETAAAGPVPEPA
                     PAH"
     misc_feature    3464..3466
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            4182..4778
                     /locus_tag="A6A06_RS27630"
                     /old_locus_tag="A6A06_20675"
     CDS             4182..4778
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003981105.1"
                     /locus_tag="A6A06_RS27630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_20675"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_242440965.1"
                     /transl_table=11
                     /translation="MRTRRAVLEAAAQVIGTRGYEAATMAEIIQRAGVTKGALYFHFAS
                     KDALARAVIAEQTDPFIPQVSDSRLQDAIDFTHQVAVALRDDPLLQAGTRIAVETTFTD
                     EPLVPYQAWIDIVTTMFAEAKESGELLPAVAPDRAAEFFVSAYMGVQLFSHASSNRHDL
                     PDRVTALWKHILPGLASPGALSHLDPHGRPVRTAA"
     gene            5001..5987
                     /locus_tag="A6A06_RS27635"
                     /old_locus_tag="A6A06_20680"
     CDS             5001..5987
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003981106.1"
                     /locus_tag="A6A06_RS27635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_20680"
                     /product="ScbA/BarX family gamma-butyrolactone biosynthesis
                     protein"
                     /protein_id="WP_073764320.1"
                     /sec_met_domain="AfsA (E-value: 4.5e-26, bitscore: 86.6,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASATLTAPSTTAGHRPFAGREHTSLSDLPPLTTTVPRQYVHRTA
                     VSEVFLTDWRRAGTDAWVVSAQWPRAHSFYSPVDGLHDPMLLVETMRQASILLSHVAHG
                     VPLDHPIIWQDLHYSLVPEALRVTGTPAEIELHITDHDLLYRGDRLASARQLYRVLCDG
                     TELASAELHFSCHSPAVYRRLRGEYSDLQRANARKLDLAEPVTPRLVARDRTGDVVLSP
                     TGHANRWQLRVNTAHPVLFDHPVDHAPGMLMMEAARQAAHAAAGPGFSLPADMTCSFRR
                     YGELDAPCWVAVTPAGRDACDRLLLDITVRQNGRPVFTARAASQSIR"
     gene            complement(6023..8344)
                     /locus_tag="A6A06_RS27640"
                     /old_locus_tag="A6A06_20685"
     CDS             complement(6023..8344)
                     /GO_function="GO:0003959 - NADPH dehydrogenase activity
                     [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003981107.1"
                     /locus_tag="A6A06_RS27640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_20685"
                     /product="bifunctional salicylyl-CoA
                     5-hydroxylase/oxidoreductase"
                     /protein_id="WP_079194375.1"
                     /transl_table=11
                     /translation="MGVRKVAVIGGGPGGLYAAALLKRLDPRRDITVWERNAPDDTFGF
                     GVVLSDETLGGIEHADPQVYRALQREFVRWDDIDIVHRGRTLTSGGHGFAALGRRTLLR
                     ILHERCRSLGVRLNFRTQAPPAAELAATHDLVIAADGVHSLTRAAHADVFGPRVTTHRC
                     RYIWLAADFAFDAFRFEIAETGHGVVQLHGYPYARAESGSRADGAAAPDGASTVIVEMR
                     EDVWRRAGLDRCDERESADWCAKVFADALGGRPLRSDNSAWIAFRTVVNERWSHGRTVL
                     LGDAAHTAHFSIGSGTKLAVEDALALAACLEEHPALPDALAAYEAERQPVVASTQRAAR
                     ASLEWFEDLAEYVGQPSRRFAFNLLTRSRRVTHDNLRLRDADFVAAVEEEAGVPAGTPP
                     MFTPFRLGGLTLRNRVVVSPMDMYSADGDGTPGDFHLVHLGARALGGAGLVLTEMVCVS
                     PEGRITPGCTGLYKPEHETAWRRVTDFVHAQAPGTAVGVQLGHSGRKGSTRLMWEGIDQ
                     PLPDGNWPLVAASALPYRPGVNQIPHALTEPELTDIRDEFVRSAQSAARAGFDLLELHC
                     AHGYLLSGFLSPLTNRRTDAYGGDLTARLRFPLEVFDAVRAVWPADRPMTVRISATDWA
                     EGGTTAEDAVEIARAFAAHGAAAIDVSTGQVVPDERPDYGRSYQTPFADRIRNRLGVPV
                     ITVGAVSSWDDVNSLILAGRADLCALARPHLYDPHWTLHAAAEQNYTGPGAPWPLPYRA
                     GSRTPPTGRTDAPKPRLTLG"
     misc_feature    8298..8312
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 25.37"
                     /tool="antismash"
     gene            complement(8347..9174)
                     /locus_tag="A6A06_RS27645"
                     /old_locus_tag="A6A06_20690"
     CDS             complement(8347..9174)
                     /NRPS_PKS="Domain: ECH (18-267). E-value: 6.5e-49. Score:
                     158.4. Matches aSDomain:
                     nrpspksdomains_A6A06_RS27645_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004982203.1"
                     /locus_tag="A6A06_RS27645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_20690"
                     /product="enoyl-CoA hydratase family protein"
                     /protein_id="WP_073764324.1"
                     /transl_table=11
                     /translation="MSPFTGSARTTDAWQHIRVTREDGIVTVTLARPDKLNALTFEAYA
                     DLRDLLAELSRERSARALVLGGEGRGFCSGGDVEEIIGATLAMDTAQLLDFNRMTGQVV
                     RAVRECPFPVIAAVHGVAAGAGAVLALAADFRVADPSARFAFLFTKVGLSGGDMGAAYL
                     LPRVVGLGHATRLLMLGEPVRAPEAERIGLLSELAEEGRADTAAHILAQRLAEGPALAH
                     AQTKALLTAELDMPLGAAVEMDAATQALLMNSADYAEFHAAFTEKRSPKWQGK"
     aSDomain        complement(8374..9120)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A6A06_RS27645_ECH.1"
                     /evalue="6.50E-49"
                     /label="A6A06_RS27645_ECH.1"
                     /locus_tag="A6A06_RS27645"
                     /protein_end="267"
                     /protein_start="18"
                     /score="158.4"
                     /tool="antismash"
                     /translation="VTREDGIVTVTLARPDKLNALTFEAYADLRDLLAELSRERSARAL
                     VLGGEGRGFCSGGDVEEIIGATLAMDTAQLLDFNRMTGQVVRAVRECPFPVIAAVHGVA
                     AGAGAVLALAADFRVADPSARFAFLFTKVGLSGGDMGAAYLLPRVVGLGHATRLLMLGE
                     PVRAPEAERIGLLSELAEEGRADTAAHILAQRLAEGPALAHAQTKALLTAELDMPLGAA
                     VEMDAATQALLMNSADYAEFHAAFTEK"
     gene            complement(9256..9840)
                     /locus_tag="A6A06_RS27650"
                     /old_locus_tag="A6A06_20695"
     CDS             complement(9256..9840)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020557769.1"
                     /locus_tag="A6A06_RS27650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_20695"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_073764326.1"
                     /transl_table=11
                     /translation="MRADARKNRDHLLAAASTAITEQGVDVSLRDIARRADVGLATLLR
                     HFPTREALLDALLRTGFDELTAKAGELQAAGPPEDALVSWLRDCVAWTTEYRGVTALMA
                     AAIEDTESALHASCVTLRAAGAQLLTRAQAAGTARGDIDGADVFALVAMLAWLGDQPSL
                     APRADHLFDVVASAILTDTQGGGARPVIAHS"
     misc_feature    complement(9908..9921)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.18"
                     /tool="antismash"
     misc_feature    9924..9941
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 23.88"
                     /tool="antismash"
     gene            9952..10962
                     /locus_tag="A6A06_RS27655"
                     /old_locus_tag="A6A06_20700"
     CDS             9952..10962
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (25-261). E-value: 3.5e-30.
                     Score: 97.1. Matches aSDomain:
                     nrpspksdomains_A6A06_RS27655_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009720855.1"
                     /locus_tag="A6A06_RS27655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_20700"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_199931189.1"
                     /sec_met_domain="ADH_N (E-value: 5.1e-10, bitscore: 35.1,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.5e-15, bitscore:
                     53.2, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTRTMRAIRLHEHGGPEVLRDDRVPIPAPGPGEVLVRVHAVGVN
                     PPDWYLRDGMADLPPETRPEYSLPVIPGTDLSGVVEAVAADVDGLAVGDQVFGLLRFPG
                     FGGSTYAEYVAAPAADLARKPAGIDHVHAAGAPMSGLTAWQFLIKVGHDHPSPFQAARH
                     HPTVLDAGTTVLVNGAAGGVGHLALQLAKWQGARVVAVASGVHESFLRDLGADEFLDYT
                     KSRPEELVHDIDLVLDTVGGPGSKRFLRTLKHGGALFPVFFGAFDDEETARLGVTVSGT
                     QVRSDGAQLAELGRLLDAGTVRVAIDSTFALADARAAHERAARGHIQGKIVLTAA"
     aSDomain        10027..10734
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A6A06_RS27655_PKS_ER.1"
                     /evalue="3.50E-30"
                     /label="A6A06_RS27655_PKS_ER.1"
                     /locus_tag="A6A06_RS27655"
                     /protein_end="261"
                     /protein_start="25"
                     /score="97.1"
                     /tool="antismash"
                     /translation="PIPAPGPGEVLVRVHAVGVNPPDWYLRDGMADLPPETRPEYSLPV
                     IPGTDLSGVVEAVAADVDGLAVGDQVFGLLRFPGFGGSTYAEYVAAPAADLARKPAGID
                     HVHAAGAPMSGLTAWQFLIKVGHDHPSPFQAARHHPTVLDAGTTVLVNGAAGGVGHLAL
                     QLAKWQGARVVAVASGVHESFLRDLGADEFLDYTKSRPEELVHDIDLVLDTVGGPGSKR
                     FLRTLKHGGALFPV"
     CDS_motif       10462..10524
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A6A06_RS27655_0001"
                     /evalue="6.00E-06"
                     /label="PKSI-ER_m5"
                     /locus_tag="A6A06_RS27655"
                     /protein_end="191"
                     /protein_start="170"
                     /score="18.8"
                     /tool="antismash"
                     /translation="GTTVLVNGAAGGVGHLALQLA"
ORIGIN
        1 tcgccgggag cccgccgctc ggcttcacct tcggcctcgg cgggctggtg gtcttcccgc
       61 tgcgggccgg tgcctcggcg ttcctggccg actggggcgg ccccgcacag ttgctgcggg
      121 acgtcgcgcg gcaccgcgtg tccgtgctgt tcaccgcgcc gaccgcctac cgggtgatgc
      181 tgccgaagct gcccgggtac gacgtctcct cgctgcgccg ctgcgtgtcg gcgggcgaga
      241 acctgcccgc cgcgacgtgg cgggcgtggg agaaggcgac cgggctgcgc atcatcaacg
      301 gcatcggcgc gacggagctg ctgcacatct tcatctcggc cgccgacgag cggatccggc
      361 cggggaccac ggggctgccg gtgccgggct tcgaggcgcg ggtggtcggc gcggacggcc
      421 ggccggtgcc ggacgggacg ccggggctgc tcgcggtgcg cggcccgacg ggctgccgct
      481 atctggcgga cgagcggcag cgggagtacg tacgcgacgg ctggaacctg accggcgaca
      541 cctacgtgcg ggacgcggac ggctacttca gctacgtggc acgggcggac gacatgatca
      601 tctcggccgg gtacaacatc gccgggcccg aggtcgagga cgcgctgctg cgccaccccg
      661 acgtcgccga ggcagccgtc gtcggccggg ccgacccgga gcgcgggcag gtcgtggtgg
      721 cccatctcgt cctgcggtcc ggcgtgccgc gcgggccgga aacggtggcg gcgctgcgcg
      781 acttcaccaa gtcggccgtg gcgccgtaca agtgcccgcg cgagatcgtc ttccacgacg
      841 cgctgccccg gacgccgacg ggcaagctcc agcgcttccg gctgcggggc ggggacggcg
      901 caggtggtga cggtgcgggc ggcggcgatg cgggtggcac cggtacggac agtgacggcg
      961 cgggcgacgc ggcatgaccg gtgacgccgt tcgcaccggc ggtgccggta tgcgatgccg
     1021 ccgtaccgcg tcccggcggc tacggctacg atcgcgccct gagcggccac ggcacggcag
     1081 ccgtccgcgc gcgcccctgc gcccccgggc cgccgaccgg agcacgacaa ggcgggaaac
     1141 gaccacgtga gcgaccagta cgcacatggc acgccgcggt ccctgatcgt caccttctac
     1201 ggtgcgtacg ggcgcggccc ggcgggcgga cccggcggcc cggagggccc ggtgccggtc
     1261 gccgcgctga tcaggctcct cggagagctc ggcgtcgacc cgccgtcggt gcgctcggcg
     1321 gtctcccgcc tcaagcgccg cgggctgctg gtcgccgccc gtacggagtc gggggcggcc
     1381 gcgtacggac tctcggacgc ggcgcaccag ctcctggacg acggcgaccg gcggatctac
     1441 ggcaagccgt ccccggggcc gtcggacggc tgggtcctgg cggtcttctc ggtgcccgaa
     1501 caggagcgcc acaagcgcca tctgctgcgc tcccggctgt cccggctcgg cttcggcacg
     1561 gccgcgcccg gcgtgtggat cgcgccgtcc catctgtacg acgagacccg gcacaccctg
     1621 gaccggctgc aactctcccc gtacgtcgac ctgttcacgg gcgcgcacgc gggcttcgaa
     1681 ccgaccgccg acgcggtggc gcgctggtgg gacctggaat ccctcgccgg ccggcaccgc
     1741 gccttcctga agacccacga accggtgctg cgccactggt cgaaccgccg ccccgtgcca
     1801 ccggaggcgg cgtaccggga ctatctgctg gcgctcgacg cctggcgccg cctcccctac
     1861 gcggaccccg gcctgccctc tcccctcctg ccggaggact ggccgggcgg ccacgcggcg
     1921 gacgtcttcg gccggctgca cgcccggctg cgggcgacgg gcgcgcggtt cgtgcgggcg
     1981 gcggtcggcg agccgggccg ggcggccgcg gccacctgac accggcgcgc ggtcagcgcc
     2041 ttcgctggtg ggccgcggcg gcggccatcg gacgcggccg ggcggcggcg acggcggaga
     2101 cgacgtcctt gaacgagccg cacatgcgcg taccggccac cgccgccaac tcgccgaagc
     2161 tgcccacccc gtaggtgacc gcgaccggct ccatacgggc cgtgaccgcc atccgcatgt
     2221 cgccgaccgt gtcccccacg taggcactct cccagggtgc cactcccagg tcggcggcgg
     2281 cccgcagcac catctccggg tgcggcttgc cgcgccggac catgtcctgg ctgatgacgg
     2341 ggcccagcag gtcgcggatg cccagcacgt cgagcagggc ttcggcgctg cgggtgcctt
     2401 tcgaggtcgc cacggccagt tcgatgccgt gggcgcgcag cgcggagagc ccggcggcga
     2461 cgccggggaa cagtaaccgc ggcccctcac gcagcacttc gtgggcgaac agctcgcggt
     2521 agcggccgat ggcggcagcc accgcctcgt ggtcctccgg catggcgagc agcttgccga
     2581 aggccggtcc tggcggcttg ccgatcgcgg cggcggcctg ccggggcgtg accgaacggc
     2641 cctgttcgga ggcgaccttg accagcagtc tgctgatggc cggcagggtg ttggcgaggg
     2701 tcccgtcgag atcgaatacg gcggccctga tggtctcgcc ggccgcggcc cgcgcggcgc
     2761 ccccgggacg tggcacggct cccgctgatt cacgcattgc tcgacacctt ccgatttcct
     2821 gtgggccctg tgcatttgtg ggtccggtca ccgtccgtga cggcggcgcc ggacgcggga
     2881 agacgtgccg gcggtgcccg cccgggaagc tgcgggcgcg ccgtggcaca ccggtgtcca
     2941 aaattggcgt gctctcgtcg gagcggcgtc tcggagccgc gtccgccccc tgacccgcct
     3001 tcgccagatt taaaaaccgt ctgcgctgtt tgtcaatgca cccagcgggg cctcggccgg
     3061 gccagaacaa cgccccatgt cggcatgctg gagcgggaac tgacggcaag tgaaccaccc
     3121 aggaaactcg ttcacctcaa ctgcaccaca gcaacactga agtaacacca atcacttgct
     3181 attgcagttt tcgaaccgca tggttggttt agtatgtaga atgcggtgcg ctcacagccg
     3241 gactagagac aggacggaca ctgtgccgac gcagcatcga gcgatacaaa gccgccaggc
     3301 tctcctccga tcggccgccg aagccttcac cgagaagggc gtgccctcct cgggaatggt
     3361 cgacatcagc cgacgcgccc ggctgagcaa gggcgccctc tacttccact tcgcgtccaa
     3421 ggaagagctc accttcgcgg tgcggaacga ggccctcggc gcgttacggg ccctggagga
     3481 cgagctgacc cacgccccgc acccggcacc cgccgccgta cgggacttcg cgatcggact
     3541 cctcggccgg gtggacaccg acgtcgtcgt acgggccggg ctgcaactgc gccccgaaac
     3601 cgccccgggc atcgccgaac cggaactcca gcagcggtgg ttcaccctct tcctggagaa
     3661 ggccacggcc gaccgggcag cgggaaagct gccgcccggc gacgatccgc ggcgctccgc
     3721 acggctgctg tccgccctcg tcgtcggcct gctgcacctc ggccacgagg accggacgtg
     3781 gtgggacaag gacgtcgtca cggatatctg gacgcagttg ctgcccggcg gggcgggcac
     3841 ggcggccgag gagaccgcgg cggccggacc cgttccggag ccggctccgg cccactgacc
     3901 gttcccgcac accgcggccg tccgctcggc gggcaatccc gccgtatccg gttgcgtacg
     3961 agccgccggc ccgggccggc ggccggttac ggagttcggc gggcgggaag tgccggctcc
     4021 ggtggggcat tgctgccaac ccggttttca ataccgcatg gttggctttt ttaatgcgcc
     4081 gaaaatagac tgaccagacc ggactcgtaa ggttgccctt aggtacgaca ccccctcaca
     4141 gagcatacgg aggacgaccg gtggtcaagc aggaacgcgc agtgcgcacg cgacgtgccg
     4201 tcctcgaagc agcagcccag gtcatcggca cacgtgggta cgaggcggcc acgatggcgg
     4261 agatcatcca gcgggccggc gtgacgaagg gcgccctgta cttccacttc gcctccaagg
     4321 acgccctcgc ccgcgccgtc atcgcggaac agaccgaccc cttcattccg caggtcagcg
     4381 actcccgcct ccaggacgcc atcgacttca cgcaccaggt ggcggtggcc ctgcgggacg
     4441 acccgctgct ccaggccggc acccggatcg ccgtcgagac cacgttcacc gacgagccgc
     4501 tggttccgta ccaggcctgg atcgacatcg tcacgacgat gttcgccgag gccaaggaga
     4561 gcggcgagct gctccccgcg gtcgcgccgg accgggcggc ggagttcttc gtctcggcct
     4621 acatgggggt gcagctcttc tcgcacgcca gctccaaccg ccacgacctg cccgatcgcg
     4681 tcacggcact gtggaagcac atcctccccg ggctggcctc gccgggtgcg ctgagccatc
     4741 tcgacccgca cggccgcccg gtgcggaccg cggcctgacc gcgactccgc ggcacctgac
     4801 cgactccccg cacccgcggg tatgtttcac cggccggggc ccgtcgcccc ggcccctccc
     4861 tccaccggca tctccccaca agaaagctgg tggaagcact agaaaacaaa ccatccggtt
     4921 tgtatcttag gccgcgtcgg tccgccaccg aggctcacgg agtccgagcg aagtgagccg
     4981 tcaccaggga gggaacccgc atggccagcg ccacgctcac cgcgccgtcc accacagcag
     5041 gccaccgtcc gttcgccgga cgggagcaca ccagcctctc ggacctgccg ccgctgacga
     5101 cgaccgtgcc ccggcagtac gtgcaccgga ccgccgtgtc ggaggtgttc ctgaccgact
     5161 ggcgccgcgc gggaaccgac gcctgggtgg tgagcgccca gtggccgcgg gcgcacagtt
     5221 tctacagccc cgtcgacggt ctgcacgacc cgatgctgct ggtggaaacg atgcggcagg
     5281 cgagcatcct gctgagccac gtggcccacg gcgtgccgct cgaccacccc atcatctggc
     5341 aggacctgca ctactccctg gttcccgagg cgctgcgcgt caccggcacg cccgccgaga
     5401 tagaactgca catcaccgat cacgacctgc tgtaccgcgg cgaccggctg gccagcgcgc
     5461 ggcagctgta ccgcgtcctg tgcgacggca ccgaactggc ctcggccgag ctgcacttct
     5521 cctgccacag cccggccgtc taccgccggc tgcgcggcga atacagcgac ctccagcggg
     5581 ccaacgcccg caagctggac ctggcggagc cggtgacacc gcgcctggtg gcccgcgacc
     5641 gcaccggcga cgtggtcctc tcccccaccg gtcacgccaa ccgctggcag ctgcgggtga
     5701 acaccgcgca cccggtcctc ttcgaccacc ccgtggacca cgccccgggc atgctgatga
     5761 tggaggccgc ccggcaggcc gcacacgccg ccgcgggccc cggtttctcc ctgcccgccg
     5821 acatgacgtg ctccttccgc cgctacggcg aactggacgc cccctgctgg gtcgcggtga
     5881 ccccggccgg acgcgacgcc tgcgaccgcc tcctcctcga catcaccgtc cggcagaacg
     5941 ggcggcccgt cttcaccgcc cgcgccgcga gccagtcgat acgctgaccc gccgacggcc
     6001 ggaagcccgg ccgcgcgccg cgtcacccca gcgtcagccg tggcttcggt gcgtccgttc
     6061 ggccggtggg cggggtgcgg ctcccggcgc ggtacggcag gggccatggc gcgccgggcc
     6121 cggtgtagtt ctgctcggcc gccgcgtgca gcgtccagtg cgggtcgtac aggtggggcc
     6181 gggccagcgc gcacaggtcg gcgcggcccg cgaggatcag ggagttgacg tcgtcccagg
     6241 acgagacggc gcccaccgtg atcaccggga cacccaggcg gttgcggatg cggtcggcga
     6301 acggggtctg gtacgagcgc ccgtagtcgg ggcgctcgtc gggtacgacc tggccggtcg
     6361 agacgtcgat ggcggcggcg ccgtgcgcgg cgaaggcacg ggcgatctcc accgcgtcct
     6421 cggcggtggt gccgccctcg gcccagtcgg tggcggagat ccgtaccgtc atgggccggt
     6481 cggcgggcca gacggcgcgc accgcgtcga agacctccag ggggaagcgc agccgggcgg
     6541 tgaggtcgcc gccgtaggcg tcggtgcgcc ggttggtgag cggggagagg aagccggaga
     6601 gcagatagcc gtgggcgcag tgcagttcga ggaggtcgaa accggcgcgg gcggccgact
     6661 gtgccgaccg gacgaactca tcgcgtatgt cggtgagttc gggctcggtc agggcgtgcg
     6721 gtatctggtt gacgccgggg cggtacggca gcgcggaggc cgccacgagc ggccagttgc
     6781 cgtcgggcag cggctggtcg atgccctccc acatgaggcg ggtggagccc ttgcggccgg
     6841 agtggccgag ctggacgccg acggcggtgc cgggcgcctg cgcgtgcacg aagtcggtga
     6901 cacgccgcca ggccgtctcg tgttccggct tgtacagacc cgtgcagccc ggggtgatgc
     6961 ggccctcggg gctgacgcag accatctcgg tcagcaccag tccggcgccg ccgagcgcgc
     7021 gggctccgag gtggacgagg tggaagtcgc ccggggtgcc gtcgccgtcg gcggagtaca
     7081 tgtccatcgg ggagaccacg acccggttgc gcagggtcag gccgcccagc cggaacggcg
     7141 tgaacatggg cggggtaccg gccggcacgc cggcttcctc ctcgaccgcc gcgacgaagt
     7201 ccgcgtcgcg cagccgcagg ttgtcgtggg tgacccggcg gctgcgggtg agcaggttga
     7261 aggcgaaccg gcgggacggc tggccgacgt actccgcgag gtcttcgaac cattccaggc
     7321 tggcgcgggc ggcccgctgg gtggaggcga cgacgggctg ccgctcggcc tcgtacgcgg
     7381 ccagcgcgtc cggcagggcg gggtgctcct ccaggcaggc ggccagcgcg agggcgtcct
     7441 cgacggccag tttggtgccg gagccgatgg agaagtgggc ggtgtgcgcg gcgtcgccga
     7501 gcagcaccgt acggccgtgg gaccagcgct cgttgacgac ggtgcggaac gcgatccagg
     7561 cggagttgtc ggagcgcagc gggcgtccgc cgagcgcgtc ggcgaagacc ttggcgcacc
     7621 agtcggcgga ctcccgctcg tcgcaccggt ccaggcccgc ccggcgccag acgtcctcgc
     7681 gcatctcgac gatgacggtg ctggcgccgt ccggggccgc cgccccgtcg gcccgtgagc
     7741 cggattccgc gcgggcgtac gggtagccgt gcagctggac gacaccgtgt ccggtttcgg
     7801 cgatctcgaa gcggaacgcg tcgaaggcga agtcggcggc gagccagatg tagcggcagc
     7861 ggtgggtggt gacgcgcggg ccgaagacgt cggcgtgtgc ggcgcgggtg aggctgtgca
     7921 cgccgtcggc ggcgatcacc aggtcgtggg tggcggcgag ttcggcggcg ggcggggcct
     7981 gcgtacggaa gttcagccgt acgccgaggg agcggcagcg ctcgtggagg atgcgcagca
     8041 gggtgcggcg gccgagggcc gcgaagccgt gcccgccgga ggtcagggtg cgcccgcggt
     8101 gcacgatgtc gatgtcgtcc cagcggacga actcgcgctg gagcgcgcgg tacacctgcg
     8161 ggtcggcgtg ctcgatgccg ccgagggtct cgtcggagag gacgacgccg aagccgaagg
     8221 tgtcgtcggg ggcgttgcgc tcccagacgg tgatgtcccg ccgcgggtcg aggcgcttga
     8281 ggagggcggc ggcgtacagg ccgcccggcc ctcccccgat gacggccacc ttccggacgc
     8341 ccacccttat ttcccctgcc acttcgggga ccgcttctcg gtgaacgcgg cgtggaattc
     8401 ggcgtagtcg gcgctgttca tcagcagggc ctgggtggcg gcgtccattt ccacggcggc
     8461 gcccagcggc atgtccagtt cggcggtgag cagtgccttg gtctgggcgt gggcgagcgc
     8521 gggcccttcg gcgagccgct gggcgaggat gtgggcggcg gtgtccgcgc gtccttcctc
     8581 ggccagttcg ctgagcaggc cgatgcgttc ggcctcgggg gcgcggaccg gttcgccgag
     8641 catcagcagc cgggtcgcgt ggccgaggcc gaccacgcgc ggcagcaggt aggcggcgcc
     8701 catgtcgccg ccggacaggc cgaccttggt gaagaggaag gcgaagcggg ccgaggggtc
     8761 ggcgacgcgg aagtcggcgg ccagggcgag caccgcaccg gcgcccgccg cgacgccgtg
     8821 caccgcggcg atcacgggga acgggcattc ccgtacggcc cgtacgacct ggccggtcat
     8881 ccggttgaag tccagcagtt gcgcggtgtc catggcgagg gtggcaccga tgatctcttc
     8941 gacgtcgccg ccggagcaga agccgcggcc ctcgccgccg aggacgaggg cgcgtgcgga
     9001 ccgctctctg gacagctcgg cgagcaggtc ccgcagatcg gcgtacgcct cgaaggtcag
     9061 tgcgttgagc ttgtcggggc gcgcgagggt gacggtgacg atgccgtctt ccctggtcac
     9121 gcggatgtgc tgccatgcgt cggtggtacg ggcggaacct gtgaacgggc tcatcgggct
     9181 actgccccct tcagccggac ggctggtacg gacacgcaat cgcgtttcga agttatcacc
     9241 gttgcgtgac tgtcgtcatg agtgcgcgat aaccggccgg gcgccgccgc cctgtgtgtc
     9301 cgtcagaatc gcgctcgcga ccacatcgaa gaggtggtcg gcgcgcgggg cgagcgaggg
     9361 ctgatcgccg agccaggcga gcatggccac cagcgcgaac acgtcggcgc cgtcgatgtc
     9421 gccccgcgcc gtgcccgcgg cctgggcgcg ggtgaggagt tgcgcaccgg ctgcgcgcag
     9481 ggtgacgcac gaggcgtgga gtgcggattc ggtgtcctcg atggctgctg ccatcagcgc
     9541 ggtcacgccc cggtattcgg tggtccaggc gacgcagtcg cgcagccacg aaacgagtgc
     9601 gtcttcgggc gggcccgccg cctggagctc gcccgccttt gccgtcagtt cgtcgaagcc
     9661 cgtgcggagc agggcgtcga gcagcgcctc gcgcgtcggg aagtgccgca gcagcgtcgc
     9721 gagcccgaca tcggccctgc gcgcgatgtc gcgcagggac acgtcgacgc cctgctcggt
     9781 gatggcggtg cttgctgctg cgagcaggtg gtcgcggttc ttcctggcgt cggcccgcat
     9841 ctgtccctct tgactatccg gatcagtggt ccatatattc ggatcagtgg tccacttatg
     9901 tggatcgctg atccggatca gcgtatcccg cagcgcggac aggagaagac gatgccgaca
     9961 cgcacgatga gggccatccg gctccatgag cacggcggcc ccgaggtgct gcgcgacgac
    10021 cgggtgccga ttcccgcgcc ggggccgggc gaggtgctcg tccgcgtgca cgcggtcggc
    10081 gtcaaccccc cggactggta cctgcgcgac gggatggccg atctgcctcc ggagacgagg
    10141 ccggagtaca gcctgcccgt gattccgggg acggacctgt cgggcgtcgt cgaggccgtc
    10201 gccgcggacg tggacggcct cgccgtcggt gaccaggtct tcggtctcct ccgcttcccc
    10261 ggcttcggcg gcagcaccta cgccgaatac gtggccgcgc ccgcggcgga cctcgcgcgc
    10321 aagccggccg gtatcgacca tgtgcacgcc gcgggtgcgc ccatgtccgg gctcaccgcg
    10381 tggcagttcc tgatcaaggt cggacatgat cacccctcgc ccttccaggc ggcgcggcat
    10441 cacccgacgg tgctcgacgc cggtacgacg gtgctcgtca acggcgccgc gggcggcgtg
    10501 gggcacctcg cgctgcaact cgcgaagtgg cagggggcac gggtcgtcgc ggtggcgtcg
    10561 ggcgtccatg aatcgttcct gcgcgacctc ggcgccgacg agttcctcga ctacaccaag
    10621 agccgccccg aggaactcgt acacgacatc gacctcgtcc tcgacaccgt cggcggcccc
    10681 ggcagcaagc gcttcctgcg cacactcaag cacggcggcg ccctgttccc ggtgttcttc
    10741 ggcgccttcg acgacgagga gaccgccagg ctgggcgtca cggtttcggg cacccaggtc
    10801 cgctcggacg gagcgcagct cgccgaactg ggacgcctgc tcgacgcggg cacggtccgg
    10861 gtcgcgatcg acagcacgtt cgcgctcgcg gacgcccgcg ccgcgcacga gcgtgccgcc
    10921 cgcgggcaca tccagggcaa gatcgtgctc accgccgcgt aggaacgagc cgcttcgcgc
    10981 gggtgca
//
