LOCUS       NZ_LWKZ01000024        25177 bp    DNA     linear   CON 28-MAR-2024
DEFINITION  Streptomyces sp. CB02923 scaffold4, whole genome shotgun sequence.
ACCESSION   NZ_LWKZ01000024
VERSION     NZ_LWKZ01000024.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CB02923
  ORGANISM  Streptomyces sp. CB02923
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 1153214)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1153214)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra,H. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-APR-2016) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2016
            Assembly Method                   :: CLC NGS Cell v. 8.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905005.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:56:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,128
            CDSs (total)                      :: 8,049
            Genes (coding)                    :: 7,904
            CDSs (with protein)               :: 7,904
            Genes (RNA)                       :: 79
            rRNAs                             :: 2, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 145
            CDSs (without protein)            :: 145
            Pseudo Genes (ambiguous residues) :: 0 of 145
            Pseudo Genes (frameshifted)       :: 32 of 145
            Pseudo Genes (incomplete)         :: 128 of 145
            Pseudo Genes (internal stop)      :: 11 of 145
            Pseudo Genes (multiple problems)  :: 22 of 145
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:21:38
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 378813
            Orig. end                         :: 403990
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LWKZ01000024.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25177
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="2dos"
                     /region_number="3"
                     /rules="((DOIS or DHQ_synthase or ValA or salQ) and
                     DegT_DnrJ_EryC1 and (LipV or ADSI-DH or cds(ADH_N and
                     ADH_zinc_N)))"
                     /tool="antismash"
     cand_cluster    1..25177
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((DOIS or DHQ_synthase or ValA or salQ)
                     and DegT_DnrJ_EryC1 and (LipV or ADSI-DH or cds(ADH_N and
                     ADH_zinc_N)))"
                     /kind="single"
                     /product="2dos"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25177
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:15177]"
                     /cutoff="20000"
                     /detection_rule="((DOIS or DHQ_synthase or ValA or salQ)
                     and DegT_DnrJ_EryC1 and (LipV or ADSI-DH or cds(ADH_N and
                     ADH_zinc_N)))"
                     /neighbourhood="10000"
                     /product="2dos"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15177
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((DOIS or DHQ_synthase or ValA or salQ)
                     and DegT_DnrJ_EryC1 and (LipV or ADSI-DH or cds(ADH_N and
                     ADH_zinc_N)))"
                     /neighbourhood="10000"
                     /product="2dos"
                     /protocluster_number="1"
     gene            complement(778..1662)
                     /locus_tag="A6A06_RS24945"
                     /old_locus_tag="A6A06_18065"
     CDS             complement(778..1662)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009714137.1"
                     /locus_tag="A6A06_RS24945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_18065"
                     /product="SigB/SigF/SigG family RNA polymerase sigma
                     factor"
                     /protein_id="WP_242440928.1"
                     /transl_table=11
                     /translation="MPSVRTRTPHLQSTKSTPGTQRGRPAERPLGTRRTQKKHPHDDAP
                     DTGADFRTLMALPDGPERDALRQSIVCAWLPMAERLARQFRNRGETTEDLTQVASLGLV
                     KAVDRYDPDRGCAFESFAVPTIVGEVKRHFRDHMWGLHVPRRVQELRNRVRTATLELTH
                     APDDHRPAARDIARHTGMTLEEVLLGMEALESYSTLSLDAELPGADDGYSLVDTLGGPE
                     PGFDLVVDREAVRPKLQSLPERERQILYLRFFCDMTQSRIADRLGISQMHVSRLINRTC
                     TRLCDQVGEREAA"
     gene            1994..3085
                     /locus_tag="A6A06_RS24950"
                     /old_locus_tag="A6A06_18070"
     CDS             1994..3085
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1268: mandelate racemase/muconate lactonizing enzyme"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003987155.1"
                     /locus_tag="A6A06_RS24950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_18070"
                     /product="enolase C-terminal domain-like protein"
                     /protein_id="WP_073763564.1"
                     /transl_table=11
                     /translation="MRVERLDVTAYTVPTDAPEADGTLAWDTTTVIVVEARSGTTTGLG
                     WTYAAADTGSVVRDLLTRPVLGRSVLDVQGAYEAMSRAVRNAGRPGLVACALSAVDIAL
                     WDLKARLLELPLLHLIGAVRSAVPVYGSGGFTTYHDTHLATQLNGWVHGQGIERVKIKI
                     GEEWGHAVERDLSRVRNARTAIGPRAELYVDANGAYTRKQAVRVGRALADQGVGWFEEP
                     VSSDDLEGLRVVRDLVVCDVTAGEYGYDLPYFARMAPVVDCLQVDATRCGGLTVWLRAA
                     ALAEAHGLEVSAHCAPHVHAHPAACVPNLRHIEWFHDHVRIESMFFDGGLDPSGGTVHP
                     GAKQLPGHGLEFRHEEATPYRVL"
     gene            complement(3134..3739)
                     /locus_tag="A6A06_RS24955"
                     /old_locus_tag="A6A06_18075"
     CDS             complement(3134..3739)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020554030.1"
                     /locus_tag="A6A06_RS24955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_18075"
                     /product="HD domain-containing protein"
                     /protein_id="WP_242440929.1"
                     /transl_table=11
                     /translation="MLIEVAGVRVPVGRAAEAARLVSEEYADAALYHHSVRSYFFGAAW
                     AEARGLDFDRELFFVSALLHDLALVPPFDSHTLPFEEAGGHLARVFTAGLGWPAERRDR
                     AAELIVLHMRDDVAPEVDVESRLLQVGTSADVSGAGLEAFDPSFRDALVGAYPRLGFAK
                     SFVRLFEEQAERKPGCAAAGLVAGDWAERTVSHPLDQG"
     gene            complement(4104..4361)
                     /locus_tag="A6A06_RS24960"
                     /old_locus_tag="A6A06_18080"
     CDS             complement(4104..4361)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003987154.1"
                     /locus_tag="A6A06_RS24960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_18080"
                     /product="DUF6158 family protein"
                     /protein_id="WP_073764567.1"
                     /transl_table=11
                     /translation="METQSATPGSATPGVPPARLDEQQLLRELETIHRTRHDTLLHGST
                     DALATHNARMAELEGEYLRRHPRRWVASGRTRSGARARTG"
     gene            4504..4701
                     /locus_tag="A6A06_RS24965"
                     /old_locus_tag="A6A06_18085"
     CDS             4504..4701
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A6A06_RS24965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A6A06_18085"
                     /product="hypothetical protein"
                     /protein_id="WP_073763565.1"
                     /transl_table=11
                     /translation="MELGFLTPLTTRPGPGSVGRSGTSDHPVRPVASFDRTRTAPALRG
                     DRRPLGVPGVTGAPADDAPG"
     gene            4799..5254
                     /locus_tag="A6A06_RS24970"
                     /old_locus_tag="A6A06_18090"
     CDS             4799..5254
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010038679.1"
                     /locus_tag="A6A06_RS24970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_18090"
                     /product="CBS domain-containing protein"
                     /protein_id="WP_073763566.1"
                     /transl_table=11
                     /translation="MAQFVRDVMTPDVAAVLPDASLVEAAQLMRAQDIGDVLVTQDGVL
                     LGVVTDRDITLRAVADGVDPLAVSCRSVCTPEPVCVGPDDHISEAVTLMRTNAVRRLPV
                     VENGTPVGVVSIGDLARAQDPDSALADISRAAPDSWPDTGIAGPGYV"
     gene            5468..6949
                     /locus_tag="A6A06_RS24975"
                     /old_locus_tag="A6A06_18095"
     CDS             5468..6949
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018090508.1"
                     /locus_tag="A6A06_RS24975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_18095"
                     /product="bifunctional phosphatase PAP2/diacylglycerol
                     kinase family protein"
                     /protein_id="WP_079194315.1"
                     /transl_table=11
                     /translation="MRKLLSTWDREIFDSVASRHWPGAQRVLPRLTRTADHGLLWMGIA
                     AGAAALGGRPMRRAALRGVASLATASAMVNTLGKRSVRRNRPLLDAVPVIRQLNRQPFT
                     TSFPSGHAASAAAFATGVAFENKWWGLALAPVAASVAFSRVYTGVHYPGDVLAGAALGV
                     GAALAVRGLAPTRAQLAPPARPAADAPSLPKGRGLFVVANHASGQRTGPRPDRVQEVRG
                     VLPEAEVVLCGDPESPPMDKALEEAAEQAAQAGGALGVLGGDGTVCAAAAVAVRHGLPL
                     AVLPGGTRNHFAYDLGIETLGDAARAVESGEAVAVDLAGFRTAPGEDPTYFLNTFSIGA
                     YPELVRVREEWAGRIGAWPAGVLAAWKVLRTADPVTVEVNGKRRELWLLFAGNCAYRGL
                     GLAPVRRHDLADGVLDVRVVHGGRLARTRLLTAALTGALRHSPVLSESRMRSVRLGGLA
                     DGSVLAYDGEVGPAAGELTICKENEALTVYRLLPE"
     misc_feature    6960..6974
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.45"
                     /tool="antismash"
     gene            7032..7895
                     /locus_tag="A6A06_RS24980"
                     /old_locus_tag="A6A06_18100"
     CDS             7032..7895
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018090507.1"
                     /locus_tag="A6A06_RS24980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_18100"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_073763568.1"
                     /sec_met_domain="PCMT (E-value: 1.5e-10, bitscore: 37.1,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPHESTVHAEGHHGPAVHRESAVYTHGHHESVLRSHTWRTAANSA
                     AYLLDALEPHMEILDIGCGPGTITADLAALVPDGRVTGLEHAPDVLEQARATAGARGQD
                     NVRFVTGDVHALDFPDDSFCVTHAHQVLQHVGDPVRALREMRRVTRPGGIVAVRDADYA
                     AMTWYPAVEGMDDWLDLYHRVARANGGEPDAGRRLRAWAREAGFADAAITSTAAAWSYA
                     TAEERAWWSGLWADRTVASSYARLAVEGGHAAEAGLHRIAGAWREWGAREDAWFGVLHG
                     EALCRV"
     misc_feature    7054..7069
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.27"
                     /tool="antismash"
     gene            7995..9113
                     /locus_tag="A6A06_RS24985"
                     /old_locus_tag="A6A06_18105"
     CDS             7995..9113
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0042578 - phosphoric ester hydrolase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0045227 - capsule polysaccharide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003981769.1"
                     /locus_tag="A6A06_RS24985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_18105"
                     /product="CapA family protein"
                     /protein_id="WP_242440981.1"
                     /transl_table=11
                     /translation="MAAGCGPQQPAAGRHGATSGQPARAAASGGFTLLATGDVLPHTEI
                     IEQARKDAHGRGHDFGPMLSGVRPLVSGADLAICHMETVYGPDGGPFTGYPAFTSPPQV
                     AAALRATGYDSCSTASNHTLDDGAAGVRRTLDALDAAGVRHAGSARTADEAARPTLLKA
                     GPAKVAQLAYTYGTNGIAVPEGQPWSVNLIDRDRILADARAARRAGADVVVVSLHWGTE
                     WQQDPDEQQHTLAQDLTAARTGGRPDIDLILGTHAHVPQAYEKVNGTWVVYGMGDQLAG
                     YMYNPQGAVDSRGNQSSMARFTFAPPAAAGRRWTVAKAEFTPQLTDVGNAFRVVPLTAA
                     AARGSAHARARDAVREVVLSRGGADDGLSMTG"
     gene            9230..9580
                     /locus_tag="A6A06_RS24990"
                     /old_locus_tag="A6A06_18110"
     CDS             9230..9580
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003981770.1"
                     /locus_tag="A6A06_RS24990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_18110"
                     /product="glyoxalase"
                     /protein_id="WP_073763570.1"
                     /transl_table=11
                     /translation="MDILGTSLRVCVTDLDAAIGVYERLTGAEAMRFEHGGVSVAAVGC
                     FFLMSGPEAQLSVLRKITATLAVKDVDDAVADLTAVGAQIIAGPLPTPIGRNLVARHPD
                     GSVFEYVDRKAA"
     gene            9616..9975
                     /locus_tag="A6A06_RS24995"
                     /old_locus_tag="A6A06_18115"
     CDS             9616..9975
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF023144.4"
                     /locus_tag="A6A06_RS24995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_18115"
                     /product="maleylpyruvate isomerase N-terminal
                     domain-containing protein"
                     /protein_id="WP_199931127.1"
                     /transl_table=11
                     /translation="MDIVTGVVEQAGPGQFARPTPCAAWNLGQLPAHMTGRNHGFAAAA
                     RGRVTSVADFAPRPVGGAPGAAFAASAREVVAAFAEPGVPERRFALPELGPDVTVRARL
                     LSLLGRSPGWPHGAP"
     gene            complement(10001..10924)
                     /locus_tag="A6A06_RS25000"
                     /old_locus_tag="A6A06_18120"
     CDS             complement(10001..10924)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (10-247). E-value: 6.4e-40.
                     Score: 129.1. Matches aSDomain:
                     nrpspksdomains_A6A06_RS25000_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) 2dos:
                     ADH_zinc_N"
                     /gene_functions="biosynthetic (rule-based-clusters) 2dos:
                     ADH_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003981771.1"
                     /locus_tag="A6A06_RS25000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_18120"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_073763572.1"
                     /sec_met_domain="ADH_N (E-value: 2.5e-10, bitscore: 36.1,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 7.3e-14, bitscore:
                     47.8, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAIIANSYGDPDQLTYTDQPDPKVPPDSVLVRVKAVGVNPVDWK
                     VLAGYLDPVMHVNFPLIPGWDVAGVVEAVGLDAPEFAVGDEVIGYVRKDEVQHGTFAEL
                     VSAPVRTLARKPAALSWQQAAGLPLAGLTAYQALDRLGVTRGETVLVHAASGGVGSLGV
                     QIAVARGARVIGTASERNHDFLRSLGAEPVTYGDGLAGRVRELSPDGVDAALDFVGNGV
                     IDVSQELLRDSSRVASIADGDVEKKGGHMVWVRPDSAGLAALADLADAGKLTVHVDTVL
                     PLSEAAEAFRRSQESRTRGKIVLEVS"
     aSDomain        complement(10184..10894)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A6A06_RS25000_PKS_ER.1"
                     /evalue="6.40E-40"
                     /label="A6A06_RS25000_PKS_ER.1"
                     /locus_tag="A6A06_RS25000"
                     /protein_end="247"
                     /protein_start="10"
                     /score="129.1"
                     /tool="antismash"
                     /translation="DPDQLTYTDQPDPKVPPDSVLVRVKAVGVNPVDWKVLAGYLDPVM
                     HVNFPLIPGWDVAGVVEAVGLDAPEFAVGDEVIGYVRKDEVQHGTFAELVSAPVRTLAR
                     KPAALSWQQAAGLPLAGLTAYQALDRLGVTRGETVLVHAASGGVGSLGVQIAVARGARV
                     IGTASERNHDFLRSLGAEPVTYGDGLAGRVRELSPDGVDAALDFVGNGVIDVSQELLRD
                     SSRVASIADGDVEKK"
     CDS_motif       complement(10427..10489)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A6A06_RS25000_0001"
                     /evalue="6.70E-07"
                     /label="PKSI-ER_m5"
                     /locus_tag="A6A06_RS25000"
                     /protein_end="166"
                     /protein_start="145"
                     /score="21.8"
                     /tool="antismash"
                     /translation="GETVLVHAASGGVGSLGVQIA"
     gene            complement(11018..11896)
                     /locus_tag="A6A06_RS25005"
                     /old_locus_tag="A6A06_18125"
     CDS             complement(11018..11896)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015431.4"
                     /locus_tag="A6A06_RS25005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_18125"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_073763573.1"
                     /transl_table=11
                     /translation="MMRSQVRPSLRNTDIDLSQFRCFIAVVDAGSFTGAAQQLQVTQPT
                     VSRAVQRLEAALNVRLLDRSTRHLSLTPEGRAFHTDLREAYAQLDQAIDRLQSSSSLRV
                     GFCWLMPEQFSRFIRRFTEEAGIDCEFLRDDTTAAGLHRGHTDVALLRGIPEGVPLTTI
                     PLWQERRVAAVSRSSPLARREHVDWAELADWPLVMNTVSGTTSPELWPAGHRPRTSVTC
                     SNFDEWLEAVAADQGMGTVPELASRRTSHPSVVYVPLRDAPTVQVSLALPERSAHPLAE
                     PLVAAVMREFC"
     misc_feature    complement(11711..11713)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(11849..11863)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.64"
                     /tool="antismash"
     misc_feature    complement(11976..11992)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.88"
                     /tool="antismash"
     misc_feature    complement(12178..12191)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.66"
                     /tool="antismash"
     misc_feature    complement(12300..12311)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.24"
                     /tool="antismash"
     misc_feature    12316..12330
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 19.66"
                     /tool="antismash"
     misc_feature    complement(12384..12398)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.25"
                     /tool="antismash"
     misc_feature    complement(12433..12450)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.85"
                     /tool="antismash"
     misc_feature    12477..12491
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.45"
                     /tool="antismash"
     gene            12780..13952
                     /locus_tag="A6A06_RS25010"
                     /old_locus_tag="A6A06_18130"
     CDS             12780..13952
                     /EC_number="4.2.3.-"
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) 2dos:
                     DHQ_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1183: 3-dehydroquinate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF013887.4"
                     /locus_tag="A6A06_RS25010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_18130"
                     /product="sedoheptulose 7-phosphate cyclase"
                     /protein_id="WP_073763574.1"
                     /sec_met_domain="DHQ_synthase (E-value: 3.3e-64, bitscore:
                     212.4, seeds: 76, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPAFQNTLDIEAELQVKYHVAITRDIFSPENPLLLETADRSNGP
                     GKQLVILDAALSGVLRERIHAYFAAHGVEVEVLEVDSGEVNKNLDTCLGIVDALERAGA
                     RRQSNPPIAIGGNVLIDVAGFSASIYRRGIPWVRVPTTLLGMIDGSVSAKTAVNHQGNR
                     NRLGTFHPAMRTIVDTGLLASLPRRHLVNGCGEILKMALIKDSRLFDLLEEHGPDLVDS
                     HFRTAPAEEVITRAIDGMQSELRDNLWEKDLRRIVDYGHTFSPPIEMAVVPELLHGEAV
                     GIDCLFTALLSYVRGWLGGTDVQRIARTMHRVGLPLDHALFYDIDTLERAMDEARLHRD
                     GDLNLPVVQRIGSCTFTQEVTRQELADVTSLLRTVAASAGQDLPALALQR"
     gene            13987..15177
                     /locus_tag="A6A06_RS25015"
                     /old_locus_tag="A6A06_18135"
     CDS             13987..15177
                     /EC_number="2.6.1.-"
                     /GO_function="GO:0008483 - transaminase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) 2dos:
                     DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003970230.1"
                     /locus_tag="A6A06_RS25015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_18135"
                     /product="DegT/DnrJ/EryC1/StrS family aminotransferase"
                     /protein_id="WP_073763575.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 7.3e-88,
                     bitscore: 291.1, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 6.3e-09, bitscore:
                     31.3, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 1.5e-08, bitscore:
                     29.8, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPGPGFEFLGDEERHNVEQVLAQWSLTRYLFDNPEEQSFVRRLER
                     DIEAHFDSGPTVAVNSGTSALATALAGLGVGPGDEVIVPGYTYVASIGSIGHFGATPVL
                     AEVDESLTLDPDDVERRITPRTRAIMAVHMLGASCDMERLRKIADRHGVLLLEDAAQAC
                     GGSYRGARLGTIGDAGAYSFNPFKVITCGEGGVALFRDHASYARGFAYQDQGWPPLRDN
                     NGVGTGEATFGLNLRMPELSAAVACAQLKRVDTVLAETRRVRNRLIELIEPHEGVRQRR
                     LHDAEGDCANVLVHTFDSAEPAREVAGQLSTKPLADSGRHYYGNMPQLSGNTSVRYARG
                     DLPRTDDLLSRSLAISVGVSDAHLGSGFGVGVRSTEEDIVRAAEKFNSAVRSAVAA"
     misc_feature    14003..14018
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.84"
                     /tool="antismash"
     gene            15224..16165
                     /locus_tag="A6A06_RS25020"
                     /old_locus_tag="A6A06_18140"
     CDS             15224..16165
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A6A06_RS25020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A6A06_18140"
                     /product="hypothetical protein"
                     /protein_id="WP_073763576.1"
                     /transl_table=11
                     /translation="MKNSLDSFSMVVPDVPAAAHLFGTVFGAQVLSAAPGRQGPDGLGE
                     DVVDDHGAPAHSALLRLDAHTQLRLLAYEATAGTTFGATAVDIGTAHFCFRVGDIEQAA
                     RFIDRYPGTRILGDVQEIPEGPLRHHKWVYFRLPWGAYGELQEWAESPSAEALELFHGQ
                     VPPSSALVPTLMGLDHVGYSVRNLESAIDVLTHSLGGRYVLGSVITPDENFMRRQFETP
                     VAARSKMAMVRVGDHTNLELFEHEVDAEREPGDRLAVGHSRLVFASDDVAGSAAELSRR
                     FGFAEAGRGDATAAGRTALLTAGSGLDVEFIS"
     misc_feature    complement(16296..16311)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 18.0"
                     /tool="antismash"
     gene            16361..17566
                     /locus_tag="A6A06_RS25025"
                     /old_locus_tag="A6A06_18145"
     CDS             16361..17566
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1088: acyltransferase 3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013884.4"
                     /locus_tag="A6A06_RS25025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_18145"
                     /product="acyltransferase"
                     /protein_id="WP_073763577.1"
                     /transl_table=11
                     /translation="MRSKQAFANSRLPSLTGLRFVAAFLVFFFHLSVEKLYDDSTNPVL
                     SKIFNPAGGVGVSFFFILSGFVLAWSAKPNRSAREFWRRRLAKIYPNHLLLWVLTLPLL
                     LWFGERVSAASGIANLALVQTWVPKLDFFFSVNRPSWSLCCELFFYLMFPWLVRLVGRL
                     GRRGTWALVAAAVAGVWLVPVLAELLPSAPGMPLDVSHPEISSGVSESQYWLVYAFPVA
                     RCLEFLLGIAVAKLVKSGDWPRVPVLGATVLLAAGYAAAVWAPVLFGLAALTVIPLTLF
                     IPAVAMADLEGRQSVLRSRTMVWLGEVSFAFYLVHQTVLRTGHNLLGHDASWDFWTASL
                     LALFFAAVTLVLAWGVYRWWEMPAMRLLTTRRTRPENMPVDVVPDPRFNAQRPVEMTAE
                     KD"
     misc_feature    complement(16368..16383)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 22.06"
                     /tool="antismash"
     misc_feature    complement(16369..16382)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.1"
                     /tool="antismash"
     gene            17653..18573
                     /locus_tag="A6A06_RS25030"
                     /old_locus_tag="A6A06_18150"
     CDS             17653..18573
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024880.4"
                     /locus_tag="A6A06_RS25030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_18150"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_073763578.1"
                     /sec_met_domain="PCMT (E-value: 1.9e-06, bitscore: 23.6,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVDHLPRPAQPSGPATAPAGTPPVTPSEPRVEGHVTGPDQART
                     TAGLESRQSALEQVGIASGWHVLDAGCGSGDFLPWLAELVGPQGSVSAVDRVAENTVRA
                     AAHMRQHAPGHAVDVRRADVLDLPHADDSFDAVWCADVLQHLDDGQLTRALRELSRVVR
                     PGGLVAVQVPDAASVTVRPGDPFVFLDFLRAAAPSCAYARQLLRGRDLHRWLRETGLAS
                     VHQHTTVIEHLAPLEPAALRFWTRICSRLARQARGTGGGWDHRWAPFADADAADHPLRS
                     RHGYVSEGTTLAIGTVPRAADVRLT"
     gene            18637..19305
                     /locus_tag="A6A06_RS25035"
                     /old_locus_tag="A6A06_18155"
     CDS             18637..19305
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF019349.4"
                     /locus_tag="A6A06_RS25035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_18155"
                     /product="FCD domain-containing protein"
                     /protein_id="WP_199931129.1"
                     /transl_table=11
                     /translation="MIEGTIERLKTQIVSGRWPLDSKIPIEDELVEELQVSRSTLRQAV
                     QALVYVGLLETAQGRGTFVRGTHEVDTVLHRYLADAELRSVLETRRGLEVEAAGLAAER
                     RSAADLDRLAAVHERQTAAQRDGRAGEFSRAAVEFHTAVVEAAGNPVLARLYGTMLGSV
                     RDSVHLGGVRRPQEHYGDAGHARILEAVRRGDPHAARKAAAEHVTTFLTALAPTDKDIR
                     "
     gene            19302..20594
                     /locus_tag="A6A06_RS25040"
                     /old_locus_tag="A6A06_18160"
     CDS             19302..20594
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003995789.1"
                     /locus_tag="A6A06_RS25040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_18160"
                     /product="MFS transporter"
                     /protein_id="WP_242440930.1"
                     /transl_table=11
                     /translation="MTPGPTPSDGAQTLFSRVAVLASCLGMVIIGGLLALYGPVVPALR
                     DRFGLAESTAGLALAAQSLGAVVGVLGFHAIHRRIGNRALLTASYLTMLVGTVTFALCG
                     VWPLMLAAAVVTGLGLGGVDFAISRLFLIGLGARGPAFLNVAHGCFGLGTVLAPAAIAV
                     IGPEHYGAAFIALGLLSLIPLACVRGIQARPTPAELAEAAPAPAHHAGGRRLAAVLLGF
                     VAIYMLHFAVQSGIGNWEPTHLHALGHSMTTATVATSMYWLAMTVGRFLVAPLARRWSA
                     PTIVTASCALMSVSILLVPVPGLAPWAYAAAGLCIGPIFPNGLNWLNRSAPASGNAMAY
                     VIAAAMLGSVAFPPVLGAVIQSQGVGALPVTLAGLCLLTVAVSAVLAVRLRGTGAATTV
                     HQEQPTTPAAPTAPAARQQDMTLTPQKKDAS"
     misc_feature    19362..19364
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            20591..21748
                     /locus_tag="A6A06_RS25045"
                     /old_locus_tag="A6A06_18165"
     CDS             20591..21748
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018542434.1"
                     /locus_tag="A6A06_RS25045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_18165"
                     /product="GDSL-type esterase/lipase family protein"
                     /protein_id="WP_073763579.1"
                     /transl_table=11
                     /translation="MTKQWVAGFRTAVISPYEETKLSEPRGFHDQTVRQVLHMAGGGDR
                     IRVRLSNRYGRTPLAVADARVAERKNADEIVTETDTGLRFEGAGQVTIPAGGEAVSDPV
                     DLSVRGGSDLVLSFHLPHDTGLATYSHMPSELAYVVSGNQAGAAALPGAEQVHGRFYVT
                     GVDVLTDGDAPVAVAFGDSWFEGVGTTHSANQRSVDILNRRLGHGWAVNQGIAGNRLLT
                     DEIGEHALARFERDVLAVPGATHVLLNFGINDLGLPGMLGLPPATADDLTAGFTELARR
                     AHDAGLTVHAGTIGPFAGAVYPGHNTPEGLATRRQVNDWIRSSGTFDSVFDVAPAVADP
                     DRPDYIRAEFDCGDGMHLNDAGARAMAETIDLDALGRPHPGAAGR"
     gene            complement(21806..23827)
                     /locus_tag="A6A06_RS25050"
                     /old_locus_tag="A6A06_18170"
     CDS             complement(21806..23827)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018519829.1"
                     /locus_tag="A6A06_RS25050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_18170"
                     /product="DUF5107 domain-containing protein"
                     /protein_id="WP_073763580.1"
                     /transl_table=11
                     /translation="MATSVRRTTLTLPAAPVGPASPLPAVRAPGDIHRVELPAGQDLPP
                     DMARQLTYAPLDSLLPVGIRDGYGRTRTETTLDALVIENDRLRATVLPGLGGRVHSLHH
                     KPTGRELLYRNPVLQPANFALNGAWFSGGIEWNTGATGHTTLSCAPVHAASVPAPDGGE
                     MLRLWEWERLRNLPFQVDLWLPEGSDFLYAGVRIRNPHLHAAPVYWWSNIAVPEDEHTR
                     VLAPADEAWHFGYEHTLRHVPVPESGGTDRTYPLRSEFPADYFYGIPDGDRRWIASLDA
                     TGHGLVHTSTDTLRGRKLFLWGAGRAGRRWQQWLTEPGTGGYAEIQAGLARTQLEHVRL
                     EGGTEFAWLEAYGPLAADPAVVHGGDWAAARREAGDRLEARLPRAEVDAAFAAWRPYAD
                     ADPKETLATGSGWGALERARTGHDLPGTPFAESTLGPDQHPWLALLHTGDFPRGSGVPV
                     APLVSAPWRDLLESAPPGPGTDLHLGIAQWHAGDRAQAVRSWERALAHGTDCRPLYCLA
                     VAEETAGETARAAQRYAEALACVPDDGPADATEHIAPLLPALVRAAVPALLAARRPGEA
                     AAALDRLPPATRTDGRLALLTAQVALAEGDAAAARAVFDHGFEVPDLREGDEVLSDTWY
                     AVAERLTAGSAPLTEAARTKARTEHPLPERYDFRMRAV"
     misc_feature    complement(24006..24021)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.55"
                     /tool="antismash"
     gene            24039..24569
                     /locus_tag="A6A06_RS42025"
     CDS             24039..24569
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A6A06_RS42025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_199931130.1"
                     /transl_table=11
                     /translation="MNDLDTLAAFPATGELGPVLNDWEEAETVLGTTLPPAFKAFLRVF
                     GGSKFDDFLRVYRAGAENEHVNLVAMTLAARKTMEDSRPHIRALLEERAVQPSQLIRWG
                     GTDNADMCFLVPHTDPDRWSVLTVIGRGREYDLYEGPVESYLLNVLRGDLVSDVFPEDF
                     PDEDPGYERNPWI"
     misc_feature    24829..24844
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.3"
                     /tool="antismash"
     misc_feature    24916..24931
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.58"
                     /tool="antismash"
     misc_feature    24990..25005
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.74"
                     /tool="antismash"
ORIGIN
        1 ccgtgctcac ggtcttcctc accggcccgg aggcgatggc ggcggaccgg ccgggcgccg
       61 cggaacgcac ggcggacacg ggccgggcag gcaccccgcg gcccggtctg tccgaggtca
      121 cccgcaacgc cgaactgatg gacctcctcg acgacatgac catggcgctc ctggagtcgc
      181 cgcgggagcc caccgccgta ctggaccggg cctgccgggt gctgcgcggg cgcttcgccg
      241 actgggtgac ggccgacctg gtgacccgcg gcggaggccc gctggtgcgg gtggcggtgt
      301 acggggccga gagggccggg ccgcccgcgc cgtacaccgg ggacgaggcg tacggcgcgg
      361 acgctccggc gggcgcgggc cgcaccggcg ccccgccccc ctcggacacc ttgacggcca
      421 cgctggccgc gcagctcccg aaggactgcc ccgtcgtcgt cgaggcggcc cgcgcgggca
      481 acgccaacct ccaggtgcgc ccggaggacc tcggcgcgtt cggccacgac gccgctgggg
      541 cgccgattct ggcccgcgcc gaggtgacgt cgtttctgtg cgtgccgctg cgggcgacgg
      601 cggggcccgt gcggggcgtc ctgacgctgt tgcgcacggg cgggcggcgg gcgttcagca
      661 tggccgaggc gggcgccgtc gaccggatgg cccgccacct ggggcgcgcg ctgcgtcctt
      721 gagcgcggcc gccaggcgtc cttgagcgcg gtcctcaggc gtccctgagc gcggccctca
      781 ggccgcttcg cgttcgccca cctggtcgca cagccgggtg caggtgcggt tgatgagccg
      841 ggagacgtgc atctgcgaga tgccgagccg gtcggcgatc cggctctgcg tcatgtcgca
      901 gaagaatcgc aggtagagga tctgccgttc gcgctcgggg aggctttgca gcttgggccg
      961 gaccgcctcg cggtcgacga cgaggtcgaa gccgggctcc gggccgccga gggtgtcgac
     1021 gagggagtac ccgtcgtcgg cgccgggcag ttcggcgtcc agggagagcg tcgagtagct
     1081 ctccagcgcc tccatgccga gcagcacctc ttccagtgtc atgccggtgt ggcgggcgat
     1141 gtcccgggcg gccgggcggt ggtcgtccgg ggcgtgggtg agctccaggg tggccgtgcg
     1201 gacgcggttg cgcagttcct ggacgcggcg gggcacgtgc aggccccaca tgtggtcgcg
     1261 gaagtgccgc ttgacctcgc cgacgatggt cggcacggcg aagctctcga aggcgcagcc
     1321 gcggtccggg tcgtaccggt cgacggcctt gaccaggccg agcgaggcga cctgcgtcag
     1381 gtcctcggtg gtctcgccgc ggttgcggaa ctgccgcgcg aggcgctcgg ccatcgggag
     1441 ccaggcgcag acgatgctct ggcgcagggc gtcccgctcc ggcccgtcgg gcagtgccat
     1501 cagcgtgcgg aagtccgcgc cggtgtccgg cgcgtcgtcg tgcgggtgct tcttctgggt
     1561 gcggcgcgtg cccagcgggc gttcggcggg ccggccgcgc tgggtgcccg gggtgctctt
     1621 ggtgctctgg aggtgcggtg tacgtgtgcg tacagagggc atggtctcgg ctccctgatc
     1681 ggtggactgg ggtccttccg cgggagcgca gccggagagc acgctcgcag agcggtttcg
     1741 ctcccacggg cgtgcctccg gtccgaagca cagggatcgc gtgcccgtag ccggtgccgg
     1801 taaacgcgcc gcccgccgaa tcggccgccg cgggctccgg tgcgggaggt ttccggcccg
     1861 tgggtcaggt aacccgtgcg ggacggtccg ctgaccacca gtcatgaacc ggtcaggagc
     1921 ggcggcggga ggggcaggac atgcgtaccg gacccggttc cccatcgaga ccgaagagga
     1981 gccctccatc accatgagag tcgagcggct ggacgtcacc gcctacaccg tccccaccga
     2041 cgcgcccgaa gccgacggca cgctcgcctg ggacaccacc accgtcatcg tcgtcgaggc
     2101 ccggtccggt acgaccaccg gcctcggctg gacctacgcc gccgccgaca ccggatcggt
     2161 cgtacgcgac ctgctcaccc gtccggtcct cggccggtcc gtactggacg tccagggcgc
     2221 ctacgaggcc atgagccggg cggtgcgcaa cgccggccgc cccgggctgg tcgcctgcgc
     2281 gctgtccgcg gtggacatcg ccctgtggga cctcaaggcg cggctgctgg aactgccgct
     2341 gctgcatctg atcggcgccg tgcggagtgc ggtgccggtc tacggctcgg gcgggttcac
     2401 cacctaccac gacacccatc tggcgacgca gttgaacggc tgggtgcacg gccagggcat
     2461 cgaacgcgtc aagatcaaga tcggtgagga gtggggccac gccgtcgaac gcgacctgtc
     2521 ccgcgtgcgc aacgcccgta cggccatcgg gccgcgcgcc gaactgtacg tggacgccaa
     2581 cggcgcctac acccgcaagc aggccgtccg ggtcggccgg gcgctggccg accagggcgt
     2641 gggctggttc gaggaaccgg tctcctcgga cgacctggag ggcctgcggg tcgtccgcga
     2701 cctggtggtg tgcgacgtga cggccggcga gtacggctac gacctgccgt acttcgcgcg
     2761 gatggccccg gtcgtggact gcctccaggt cgacgccacc cggtgcggcg gcctgacggt
     2821 ctggctgcgc gccgcggccc tcgccgaagc gcacggcctg gaggtctccg cccactgcgc
     2881 cccgcacgtc cacgcccacc cggccgcgtg cgtaccgaac ctgcggcaca tcgagtggtt
     2941 ccacgaccac gtacgcatcg agtcgatgtt cttcgacggc ggcctcgacc cgtccggcgg
     3001 cacggtccat cccggcgcga aacagctccc gggccacggc ctggaattcc gccacgagga
     3061 ggcgactccg taccgggtcc tgtgaagcgg cggacaaccg gtgcggagcg ggagacccgg
     3121 gcgcgcgaga ccctcagccc tgatcgagcg gatgggacac cgtccgttcc gcccagtccc
     3181 ccgccaccag acccgccgcg gcgcaccccg gcttgcgctc cgcctgctcc tcgaacaggc
     3241 gcacgaagga cttggcgaag cccagccggg ggtacgcccc gacgagcgcg tccctgaaag
     3301 acgggtcgaa ggcctccaga cccgcccccg acacatccgc gctggtcccc acctgcaaca
     3361 gcctgctctc cacgtccact tccggcgcga cgtcgtcccg catgtgcagc acgatcagct
     3421 cggccgcccg gtcacgtcgc tcggccggcc agccgagacc ggcggtgaag acccgggcca
     3481 ggtgaccgcc ggcctcttcg aagggaagcg tgtggctgtc gaagggcggc acgagagcca
     3541 ggtcgtgcag cagcgccgag acgaagaaca gctcgcggtc gaagtcgagg ccacgcgcct
     3601 ccgcccaggc cgcaccgaag aagtacgacc gcacggagtg gtggtacagc gccgcgtcgg
     3661 cgtattcctc actcaccagc cgcgccgcct ccgccgcccg ccccaccggc acacgcaccc
     3721 cggcaacctc gatcagcatc cgcccaaccc cctgacagcc gaacatcatt ccagtgcgcg
     3781 cagcttacaa gccgctccaa tgggcgggat ctcgcgtcgt gttgccgcac cgggtccggc
     3841 tccccgggcg ggaccgtccc gggcactcgt accgctgccg cttccgctgc cgcgcggagg
     3901 gccgcacgga ggtccgggcg cgggacccca catcccgcgc ccggacactc ctccccaccg
     3961 gccttgcccc gcgccgttcc cgggaccttc tccgtggccg ctcggccgga cagccgggtt
     4021 accaggaccg cgcgcggcca aacatcgcga ggtcgccgac cggtgtcgcg gggcgttcag
     4081 ccgctgcggg cgcgggctcc ggatcagccg gtgcgggcgc gggctccgga gcgggtgcgg
     4141 cccgaggcga cccagcggcg cgggtggcgg cgcaggtact cgccttccag ttccgccatg
     4201 cgcgcgttgt gggtggcgag cgcgtcggtg gagccgtgca gcagggtgtc gtgccgggtg
     4261 cggtggatgg tttccagctc gcgcaacagc tgctgctcgt cgagccgggc gggcgggact
     4321 cccggtgtgg cggagcccgg tgtggcggat tgcgtctcca tgggctgcgg ggagtccgtg
     4381 ggcgtgtcgt gggacggcat cggggtttct ccctccgtgt cgggtgcgtc ccttcgggta
     4441 cccgctggca cgaccccccg gacatgtccg gcggcaggcc cggagcgagc cccggaggca
     4501 ggcatggaac tcggattcct caccccactc actaccaggc cgggccccgg ctccgtgggc
     4561 cgttccggca cctcggacca cccggtccgc ccggtcgcct ccttcgatcg tacgaggacc
     4621 gctccggctc tgcgcggcga ccggcgcccc ctcggcgtgc ccggcgtcac cggcgcgccc
     4681 gcggacgacg ccccggggtg acgggccccg gggcgccctc gtgccccggg ccgcccggcc
     4741 gtcccccgcg gaccccctcc tgccgcccgc cggcccgacc gagagaaggc gaacagcaat
     4801 ggcacagttc gtaagggacg tcatgacccc ggacgtcgcg gccgtcctgc cggacgcctc
     4861 gctcgtcgag gccgcgcagc tgatgcgcgc gcaggacatc ggagacgtcc tggtgacgca
     4921 ggacggtgtg ctgctggggg tggtgaccga ccgcgacatc acgttgcggg cggtggccga
     4981 cggggtcgat ccgctcgccg tgtcctgccg ctcggtgtgc acccccgagc cggtctgcgt
     5041 cggccccgac gatcacatca gcgaggcggt cacgctgatg cgcacgaacg cggtgcggcg
     5101 actgccggtg gtcgagaacg ggacgccggt gggggtggtc agcatcggtg acctggcgcg
     5161 cgcgcaggac ccggactcgg cgctcgcgga catcagccgg gccgccccgg acagctggcc
     5221 ggataccggg atcgcgggtc ccgggtacgt ctgagggccc gatgtacgcc tgagggcccg
     5281 atgtgcgcct gagggcccga tgtgcgcccg agattccggt gtgcgcccga gatcccgggc
     5341 ctcgaccggt cattttcgac cgattcaccc gtttccactc gacaggagcc ggttgcagat
     5401 gaaacggacg acgcggggaa ccgtggggct gctgtatgtg cccccttctt cggggtacag
     5461 gtggcccatg cgaaagctgc tgagcacctg ggaccgcgag attttcgaca gcgtcgcgtc
     5521 acggcactgg ccgggcgcgc agcgcgtgct gccacggctg acgcgcaccg ccgaccacgg
     5581 gctgctgtgg atggggatcg cggcgggcgc ggccgccctc ggcgggcggc cgatgcggcg
     5641 ggccgcgctg cgcggggtgg cctcgctggc gacggcgtcg gcgatggtca acaccctggg
     5701 caagcgctcg gtccggcgca accggccgct gctggacgcc gtgccggtca tacggcagct
     5761 gaaccggcag cctttcacca cgtccttccc gtccggccac gcggcctcgg ccgcggcctt
     5821 cgccacgggc gtcgcgttcg agaacaaatg gtgggggctg gcgctggcgc cggtcgccgc
     5881 ctccgttgcg ttctcccgcg tctacacggg cgtccactac cccggcgacg tactggcggg
     5941 tgccgcgctc ggcgtgggcg cggccctcgc ggtgcgcggg ctcgcgccga cccgggcgca
     6001 gctggcgccc ccggcgcgcc cggcggccga cgcgccctcg ctgccgaagg gccgcgggct
     6061 gttcgtggtg gccaaccacg cgtccgggca gcgcaccggc ccgcgccccg accgggtgca
     6121 ggaggtgcgc ggtgtcctcc cggaggcgga ggtggtgctg tgcggcgacc cggagtcccc
     6181 gccgatggac aaggcgctgg aggaggccgc cgagcaggcc gcgcaggcgg gcggcgcgct
     6241 gggggtgctg ggcggtgacg gcacggtctg cgccgcggcg gcggtcgccg tacggcacgg
     6301 tctgccgctg gcggtgctgc ccggcggtac ccgcaaccac ttcgcgtacg acctgggcat
     6361 cgagacgctc ggggacgccg cgcgggcggt ggagagcggt gaggcggtcg cggtggacct
     6421 ggccgggttc cgcaccgcgc ccggcgagga ccccacctat ttcctcaaca ccttctccat
     6481 cggcgcgtat ccggagctgg tgcgcgtacg ggaggagtgg gcgggccgga tcggggcctg
     6541 gccggccggg gtgctggccg cgtggaaggt gctgcgcacg gccgacccgg tgacggtcga
     6601 ggtcaacggg aagcggcggg agctgtggct gctgttcgcg ggcaactgcg cttaccgcgg
     6661 gctgggcctg gcgccggtgc gccggcacga cctggcggac ggcgtgctgg acgtacgcgt
     6721 ggtgcacggc ggccggctgg cccgtacacg gctgctgacc gcggccctga cgggggcgct
     6781 gcggcactcc cccgtcctga gcgagtcccg gatgcgttcg gtgcggctgg gtggcctggc
     6841 ggacggcagc gtactcgcgt acgacggtga agtgggtccg gctgcgggcg agttgacgat
     6901 ctgcaaggag aacgaggcgc tgaccgtcta ccgcctgctg cccgaatagc gagacggcgt
     6961 tctcatgatg cggtcttccg acgtacggtg accacacctg ccgtccgggg agcgcgaagg
     7021 agccgtccgc catgccgcac gagtccaccg tccacgccga gggccaccac gggcccgccg
     7081 tccaccgcga gtccgccgtg tacacccacg gccaccacga gtccgtcctg cgctcgcaca
     7141 cctggcgcac cgcagccaac tcggcggcgt acctgctgga cgcgctcgaa ccgcacatgg
     7201 agatcctgga catcggctgc ggacccggca ccatcacggc cgacctcgcc gcgctggtgc
     7261 cggacggccg ggtgaccggg ctggagcacg cgccggacgt gctggagcag gcgcgggcca
     7321 ccgccggggc gcgcggccag gacaacgtcc gcttcgtgac cggcgatgtc cacgcactgg
     7381 acttcccgga cgactccttc tgcgtcacac acgcccacca ggtcctccag cacgtgggcg
     7441 acccggtgcg ggcactgcgc gagatgcggc gcgtgaccag gccgggcggc atcgtggccg
     7501 tacgggacgc ggactacgcg gccatgacct ggtacccggc ggtggagggc atggacgact
     7561 ggctggacct ctaccaccgg gtggcccgcg ccaacggcgg tgagccggac gcggggcggc
     7621 gcctgcgcgc ctgggcacgc gaggccggat tcgccgacgc cgcgatcacc tcgacggccg
     7681 ccgcgtggag ctatgcgacc gcggaggaac gcgcctggtg gagcggcttg tgggcggacc
     7741 ggacggtggc ctcctcgtac gcccggctgg cggtggaggg cggccacgcc gccgaggccg
     7801 ggctgcaccg gatagccggt gcctggcggg agtggggcgc ccgggaggac gcctggttcg
     7861 gcgtgttgca cggcgaggcc ctctgccggg tctgacccga ccgccacaac cggcacgaac
     7921 tatctcattc caggcggtat gaaggatccg tgagaagaac gcacggaccg gccgccctgg
     7981 cagtgctggc gctcctggcg gcgggctgcg gtccccagca gcccgccgcc gggcgccacg
     8041 gcgccacgtc ggggcagccc gcccgagccg cggcgtccgg cggcttcacc ctcctggcca
     8101 ccggcgacgt cctcccgcac accgagataa tcgagcaggc ccgcaaggac gcgcacggcc
     8161 gcggccacga cttcggcccc atgctctccg gcgtccggcc cctggtgtcc ggcgccgacc
     8221 tggcgatctg ccacatggag acggtgtacg gcccggacgg cggccccttc accggctacc
     8281 cggcgttcac ctcgccgccg caggtcgccg ccgccctccg ggccaccggc tacgactcgt
     8341 gctccaccgc ctccaaccac accctggacg acggcgccgc cggggtacgg cgcaccctcg
     8401 acgccctgga cgcggccggt gtacggcacg ccggctcggc ccgtaccgcc gacgaggccg
     8461 cccgccccac cctcctcaag gcgggcccgg cgaaggtcgc acagctcgcg tacacgtacg
     8521 gcaccaacgg catcgccgtg cccgaagggc agccctggtc ggtcaacctc atcgaccggg
     8581 acaggatcct cgccgacgca cgggccgccc gccgcgcggg cgccgacgtg gtggtggtca
     8641 gcctccactg gggaaccgaa tggcagcagg accccgacga gcagcagcac accctggccc
     8701 aggacctcac cgccgcccgc accggcggcc gccccgacat cgacctgatc ctcggcaccc
     8761 acgcccacgt cccgcaggcg tacgagaagg tcaacggcac ctgggtcgtc tacggcatgg
     8821 gcgaccagct cgccggctac atgtacaacc cgcagggcgc ggtcgattcg cgcggcaacc
     8881 agagctcgat ggcccggttc accttcgcgc cgcccgccgc ggcaggacgg cgctggacgg
     8941 tcgccaaggc ggagttcacc ccgcaactca ccgatgtcgg caacgctttc cgcgtcgtcc
     9001 cgctgaccgc cgccgcggcc cgcggctccg cccacgcgcg ggcgcgggac gccgtacgcg
     9061 aggtggtcct ctcccgcggc ggcgcggacg acggcctgtc gatgaccggg tgagcgggtg
     9121 cccggttgag cgggtgagca gggggccaac cccggccccc tgccccaggc cccacacgga
     9181 atcaaccaac tgatcgcgta cggcaaggca ccccaactac gctcgtccca tggacattct
     9241 ggggacctcg ctgcgggtgt gtgtgaccga cctcgacgcg gcgatcggtg tgtacgaacg
     9301 gctgaccggc gccgaggcga tgcgcttcga gcacggcggc gtctcggtcg cggccgtggg
     9361 ctgcttcttc ctgatgagcg gtccggaggc gcagttgtcg gtgctccgca agatcaccgc
     9421 gaccctggcc gtcaaggacg tggacgacgc ggtggccgac ctgacggcgg tcggcgcgca
     9481 gatcatcgcg ggcccgctgc cgaccccgat cggccgcaac ctcgtcgccc gccacccgga
     9541 cggctcggtc ttcgagtacg tcgaccggaa ggcggcctga tgcccggcgg cttacacccg
     9601 cggcaccggg ccgtcatgga catcgtgacc ggcgtcgtgg agcaggccgg tcccgggcag
     9661 ttcgcccggc ccaccccgtg cgcggcgtgg aacctcggtc agctgccggc ccacatgacg
     9721 ggccggaatc acggcttcgc cgccgccgca cgcggtcggg tcacctcggt ggccgacttc
     9781 gcaccacggc cggtgggcgg ggcgcccggt gccgcgttcg ccgcctcggc gcgcgaggtg
     9841 gtggccgcgt tcgccgaacc gggcgtgccg gagcgccggt tcgcgctgcc cgaactgggc
     9901 ccggacgtca ccgtccgggc ccggttgctg tcgctcctcg gccgctcccc cggctggccg
     9961 cacggcgccc cctgaccgca cgcggcccgg ccggcgccgg tcaggagacc tccaggacga
    10021 tcttcccgcg ggtgcggctc tcctggctgc ggcggaacgc ctccgccgcc tcggacagcg
    10081 gcaggaccgt gtcgacgtgc acggtgagct tcccggcgtc ggcgaggtcc gccagcgctg
    10141 ccagaccggc gctgtccggc cgcacccaca ccatgtgccc gcccttcttc tccacgtcgc
    10201 cgtcggcgat ggaggcgacc cgggaggagt cccgcagcag ttcctgcgag acgtcgatga
    10261 cgccgttgcc cacgaagtcc agggccgcgt ccaccccgtc gggggacagt tcccgcaccc
    10321 gaccggccag gccgtcgccg tacgtcaccg gctcggcacc gagggagcgc aggaagtcgt
    10381 ggttgcgctc gctggccgta ccgatgacgc gggcgccgcg ggcgaccgcg atctgcacgc
    10441 cgagcgaccc gacgccgccc gacgcggcgt gcaccaggac ggtctcgccc ctggtcacgc
    10501 cgagccggtc gagcgcctgg tacgcggtga gtccggcgag cggcagcccg gcggcctgct
    10561 gccagctcag cgcggcgggc ttgcgcgcca gtgtgcgcac cggggcggag accagctcgg
    10621 cgaacgtgcc gtgctgcacc tcgtccttgc ggacgtaccc gatcacctcg tcgccgaccg
    10681 cgaactcggg tgcgtccaag ccgaccgcct cgaccactcc ggccacgtcc cagccgggga
    10741 tcagcgggaa gttgacgtgc atcaccgggt ccagatagcc cgccagcacc ttccagtcga
    10801 cgggattgac cccgacggcc ttcacccgca ccagcaccga gtccggcggc accttggggt
    10861 cgggctggtc ggtgtaggtg agctggtcgg ggtcgccgta gctgttcgca atgatcgcct
    10921 tcatgctcgt cacaacgcgt gacgggaccg gatcattccg cgcggcaccc gatcggcgta
    10981 cgcatccggg tggcggcgga tgtgcggtgg agttccctca gcagaactcc cgcatgacag
    11041 cggccaccag cggctcggcc aaggggtgcg cgctgcgttc gggcagcgcc aaggacacct
    11101 ggaccgtggg ggcgtcgcgc agcggcacgt agacgacgga ggggtggctg gtgcgccggg
    11161 acgccagctc gggcacggtg cccatgccct ggtccgccgc caccgcttcg agccattcgt
    11221 cgaagttgct gcaggtgacg gaggtccggg ggcggtgtcc cgccggccag agctccggcg
    11281 aggtggttcc gctcacggtg ttcatgacca gtggccagtc ggcgagttcg gcccagtcca
    11341 cgtgctcgcg ccgggccagg ggcgagctcc gggagacggc tgccacccgc cgctcctgcc
    11401 agagagggat cgtggtgagg ggtacgcctt cggggatgcc gcgcaggagg gcgacatcgg
    11461 tgtgtccgcg gtgcagaccg gccgcggtgg tgtcgtcgcg caggaattcg cagtcgattc
    11521 ccgcttcttc cgtgaaccgc cggatgaagc gggagaattg ttcgggcatc agccagcaga
    11581 aaccgacccg cagggaagac gacgactgga gccggtcgat cgcctggtcc agctgggcat
    11641 acgcttcccg caggtccgta tggaacgccc ggccttcggg ggtgaggctg agatgacggg
    11701 tggagcggtc taacagccgc acattgagcg cggcttccag acgctggacg gcacgggaga
    11761 cagtgggctg ggtcacttgc agctgctggg ccgcgccggt gaaacttccg gcatccacca
    11821 ccgctatgaa gcaccggaat tgcgacagat cgatatcggt gttccgtaga ctcggacgta
    11881 cctgacttcg catcatgttt tcccctcaga cttccccgcg atgacgaatc gatcagggac
    11941 gaacaagggg agtgcggcga tcacgccgta agaaatgcgg gcttcttcag caggcagact
    12001 caccgaacaa gcgccatgcg aagcgccgcg tgctccgttg cacgcccgcc gctcccccgt
    12061 tggtttggca tgtacttcgg actgccggcg gcggcgcgga gtaccgaccg ccgcggatgc
    12121 caccacccga tggccgggaa tctagcaccg ggcgctttgc ggcgcgctgg ttgaacttgc
    12181 aagtttttac actgccgtcc gcgccgcgcc cgatgatcca ccgcctttga gccactcgcg
    12241 gcgcgaatca cgctcaagag tgccacatta tgggacatct cgaccatgcg agtcatggcg
    12301 taaacgactt cggtcaatat tcagcaaagt caatgcaaat cgcccaacct gccacatagg
    12361 caagttcaaa gcgcaacttg atttggccga tcaacaccct ggagaacccc tcccgggcgg
    12421 catcatgaag tcttaacact cccttaatga aactgtaccg accacgcaga actgcgttct
    12481 ccttcggcga tcccggtact tcctcagggc gcggcgcgca ggggtcgatg cccgcgaatg
    12541 aacttatacg cctgctgtat gagtgatgcg ccgccatcat tttccttgaa ggttcgcacc
    12601 tgcttggagt tccatactcc cgggacacgg acttcgaacc ccggcatgtc accgtcacct
    12661 gtcgccgaaa tggccacggg cactcagagc cgagtgaccg gcaccgcccg gaagccagac
    12721 agctttcctg cacgccgccc ccttcccccc ttgtttcctt cccacaggag aaagcaatca
    12781 tgccccctgc attccagaac accctggaca tcgaagccga actgcaggtg aagtaccacg
    12841 tcgccattac ccgggacatc ttctctccgg aaaacccgct gctcctcgaa accgccgacc
    12901 gcagcaacgg ccccggaaag cagctcgtga tactcgacgc ggcgctttcc ggagtcctgc
    12961 gggaacgcat ccacgcgtac ttcgccgcgc acggcgtcga ggtcgaggtg ctcgaagtcg
    13021 actccggcga agtcaacaag aacctcgaca cgtgcctcgg catcgtcgac gcgctggagc
    13081 gcgcgggagc acgccgccag agcaacccgc ccatcgccat cggcgggaac gtgctcatcg
    13141 acgtcgcggg cttctccgcg agcatctacc gccgcggcat cccctgggtc cgggtgccca
    13201 ccactctgct ggggatgatc gacggcagtg tctccgcgaa gacggcggtg aaccaccagg
    13261 gcaaccgcaa ccgcctgggc accttccacc cggcgatgcg gaccatcgtc gacaccgggc
    13321 tgctcgcctc gctgccccgg cggcacctgg tcaacgggtg cggcgagatc ctcaagatgg
    13381 ccctgatcaa ggacagccgg ctgttcgacc tgctggagga gcacggtccc gatctcgtcg
    13441 actcccactt ccgcaccgcg cccgcggagg aggtcatcac gcgcgcgatc gacggtatgc
    13501 agtccgaact gcgcgacaac ctgtgggaga aggacctgcg ccgcatcgtg gactacggcc
    13561 acacgttcag ccccccgatc gagatggcag tcgtccccga actgctgcac ggcgaggcgg
    13621 tgggcatcga ctgcctgttc accgcgctgc tctcgtacgt ccggggctgg ctcggcggga
    13681 ccgacgtcca gcggatcgcc cgcaccatgc accgcgtcgg cctccccctc gaccacgcgc
    13741 tgttctacga catcgacacg ctggagcgcg cgatggacga agcgcggctg caccgcgacg
    13801 gcgacctcaa cctcccggtc gtccagcgga tcggctcctg cacgttcacc caggaagtga
    13861 cccgccagga gctggccgac gtcacctcgc tcctgcggac cgtcgcggcg tccgccggcc
    13921 aggacctgcc cgctctcgct ctgcagcgct gagaacccca cccctcgcac cccacaggag
    13981 acacccatgc cgggtcccgg attcgaattc ctcggcgacg aggagcggca caacgtcgag
    14041 caggtgctcg cccagtggag cctcacccgt tacctgttcg acaacccgga ggagcagtcc
    14101 ttcgtccgtc ggctggagcg cgacatcgag gcccacttcg acagcggccc caccgtcgcg
    14161 gtcaacagcg gaacctcggc gttggccacg gccctcgccg gcctgggtgt cggtccgggc
    14221 gacgaggtca tcgtgcccgg ctacacctat gtcgcctcca tcggctcgat cggccacttc
    14281 ggcgcgacgc cggtcctcgc ggaggtcgac gagtccctga ccctcgaccc ggacgacgtc
    14341 gagcgcagga tcacgccccg cacccgcgcc atcatggccg tgcacatgct gggtgcctcg
    14401 tgcgacatgg aacggctccg gaagatcgcg gaccggcacg gcgtcctgct gctggaggac
    14461 gccgcgcagg cctgcggagg aagctaccgc ggtgcccggc tcggcacgat cggcgacgcc
    14521 ggtgcctact ccttcaaccc gttcaaggtg atcacctgcg gtgaaggggg cgtggcgctc
    14581 ttccgcgacc acgcgtcgta cgcccgcggt ttcgcctacc aggaccaggg ctggcctccc
    14641 ctgcgcgaca acaacggcgt cggcacgggc gaagcgacgt tcgggctgaa cctgcggatg
    14701 cccgaactga gcgcggccgt ggcgtgcgcc cagctgaagc gggtcgacac ggtgctcgcg
    14761 gagacccgcc gcgtccggaa ccggctgatc gagctgatcg agccgcacga gggcgtacgg
    14821 cagcgccgcc tccacgacgc cgaaggcgac tgcgccaacg tcctcgtgca caccttcgac
    14881 agcgcggagc cggcccgcga ggtcgccggg cagctgtcca ccaagccgct cgccgactcc
    14941 ggccgccact actacggcaa catgccccag ctgagcggca acacctccgt ccgctacgcg
    15001 cgcggagacc tgccgcgcac cgatgacctg ctgtcccgtt ccctcgccat ctcggtgggc
    15061 gtctcggacg cccacctcgg ctccggcttc ggcgtggggg tgcgcagcac ggaggaagac
    15121 atcgtccgcg cggcggagaa gttcaactcc gccgtccggt ccgcagtggc cgcgtgatcg
    15181 tgcgcaaccg ctccgcccac ccctcggaag aacggatcac ttggtgaaga acagcttgga
    15241 cagcttctcg atggtcgtgc cggacgtgcc cgcggcggcg cacctgttcg ggacggtctt
    15301 cggtgctcag gtgctgtcgg ccgcacccgg gcggcagggc ccggacgggc tgggcgagga
    15361 cgtcgtcgac gaccacggtg cgcccgcgca cagcgccctg ctccgtctcg acgcccacac
    15421 gcagctgcgc ctgctggcgt acgaggcgac cgccgggacg acgttcggcg cgacggccgt
    15481 ggacatcggc accgcgcact tctgcttccg tgtcggtgac atcgagcagg cagcccggtt
    15541 catcgaccgc tatccgggga ccaggatcct gggcgacgtc caggagattc ccgagggccc
    15601 gctccgccac cacaagtggg tctacttccg cctgccgtgg ggggcctacg gcgagctgca
    15661 ggagtgggcc gagtccccct ccgcggaggc cctggagctc ttccacggcc aggtgccccc
    15721 gtcgtcggcg ctggtgccca cgctcatggg cctcgaccac gtcggctaca gcgtccggaa
    15781 cctggagagc gcgatcgacg tcctgacgca ctccctgggc ggccggtacg tgctggggtc
    15841 cgtcatcacc ccggacgaga acttcatgcg gcggcagttc gagaccccgg tcgccgcccg
    15901 gtcgaagatg gccatggtgc gcgtcggtga ccacaccaac ctcgaactct tcgagcacga
    15961 ggtggacgcg gagcgcgaac ccggcgaccg gctcgccgtc ggacactccc gcctggtctt
    16021 cgcctcggac gacgtggccg gctccgcggc cgagctgtcg cggcgcttcg gcttcgccga
    16081 ggccgggcgc ggcgacgcga cggcggccgg gcgcacggca ctgctcaccg cgggatcggg
    16141 cctggacgtc gagttcatct cctgacgtag cggggcgccg cggccggacg ccgcgcccgg
    16201 actccggcat gccgacgccg gagtccgggc gcggtcggtc caccggccgc cggccgcccg
    16261 gttccgtgcc ctcccgccgc ggcccgcacc atcacgtttc cacccggaaa tcctccggcc
    16321 cgcagacggc cggagtcgca ccacgaacaa ggaaccacac gtgagatcca aacaggcatt
    16381 cgccaattcg cgcctcccct ccctgaccgg cctgagattc gtggccgcct tcctggtctt
    16441 cttcttccat ctcagcgtcg agaagctgta cgacgacagc acgaaccccg tgctgtcgaa
    16501 gatcttcaac ccggccggag gcgtgggcgt ctcgttcttc ttcatcctga gcgggttcgt
    16561 gctggcgtgg tcggcgaagc cgaaccgctc cgcgcgtgag ttctggcgcc gccgtctggc
    16621 gaagatctac ccgaaccacc tgctgctctg ggtgctcacc ctgccgctgc tgctctggtt
    16681 cggggagcgc gtctcggccg cgtccggcat cgcgaacctc gccctggtgc agacctgggt
    16741 accgaagctg gacttcttct tcagcgtgaa ccggccgagc tggtcgctgt gctgcgagct
    16801 gttcttctac ctgatgttcc cgtggctggt gcggctggtc ggacggctcg gccggcgcgg
    16861 cacctgggcc ctcgtcgccg cggccgtggc gggcgtctgg ctggtgcccg tgctcgccga
    16921 actcctgccg agcgcgcccg gcatgccgct ggacgtgtcg caccccgaga tctccagcgg
    16981 cgtgtccgag agccagtact ggctggtcta cgccttcccg gtggcgcgct gcctggaatt
    17041 cctcctgggc atcgccgtgg ccaagctggt gaagagcggc gactggccgc gggttcccgt
    17101 gctgggggca acggtcctgc tggccgccgg atacgcggcg gccgtctggg cgccggtcct
    17161 cttcggtctc gccgcgctca ccgtgattcc gctgacgctg ttcattcccg cggtcgcgat
    17221 ggccgacctg gaggggcggc agtccgtcct gcggagccgg accatggtct ggctgggcga
    17281 agtgtccttc gccttctacc tcgtgcacca gaccgtcctg cggaccgggc acaacctgct
    17341 cggccacgac gcgtcctggg acttctggac ggcgtccctg ctcgccctgt tcttcgcggc
    17401 ggtcaccctc gtcctcgcct ggggcgtcta ccgctggtgg gagatgccgg ccatgcgtct
    17461 gctgaccacc cgccggaccc ggcccgagaa catgcccgtg gacgtggtcc ccgacccccg
    17521 gttcaacgcg cagcgcccgg tggaaatgac cgccgagaag gactgaaccg cgggtccgcc
    17581 gcacgcggcc cggcgccccc gccgcagggc cgtaccgccc cgcccatccc gcagaccaga
    17641 aggagtatcg gaatgttgtc cgtggatcac ctcccgcgtc ccgcccagcc ctccgggccg
    17701 gccaccgcgc cggccggtac gcccccggtc acaccgtcag aaccgcgcgt cgaagggcac
    17761 gtcaccggtc cggaccaggc ccgtaccacg gccggcctgg agtcgcgcca gtccgcgctg
    17821 gagcaggtgg gcatcgcctc cggatggcac gtactggacg cggggtgcgg gagcggcgac
    17881 ttcctgccct ggctggccga gctggtgggc ccgcagggaa gcgtgtcggc cgtcgaccgg
    17941 gtcgcggaga acacggtgcg tgcggccgcg cacatgcgtc agcacgctcc gggacacgcg
    18001 gtggacgtgc ggcgggcgga cgtgctggac cttccgcacg ccgacgattc cttcgacgcc
    18061 gtctggtgcg cggacgtcct ccagcacctg gacgacggac agctcacccg ggcgctgcgg
    18121 gagctgtcca gggtcgtgcg gcccggtggt ctggtggccg tgcaggtccc ggacgccgcg
    18181 tcggtcacgg tgcggcccgg cgatccgttc gtcttcctcg acttcctgcg tgcggcagcg
    18241 ccttcgtgcg cgtacgcacg gcagttgctg cgcggccgtg acctccaccg ctggctgcgc
    18301 gagaccggcc tcgcttcggt gcaccagcac acgaccgtga tcgagcacct cgctccgctg
    18361 gagcccgcgg cgctgcggtt ctggacccgg atctgctccc ggctcgcccg gcaggcgcgc
    18421 ggcacgggcg gcggctggga tcaccggtgg gccccgttcg cggacgccga cgccgcggac
    18481 caccccctcc gttcccggca cgggtacgtc agtgagggca ccacgctcgc catcggcacg
    18541 gttccgcgcg ccgccgatgt taggcttacc taactaaggg atgatgatac gttctttgcg
    18601 gaggtgggcg acgtgcgcgc ggtaccacgg tcagccttga tcgaaggcac catcgaacgg
    18661 ctgaagaccc agatcgtcag cggcagatgg cctctggaca gcaagatccc catcgaggac
    18721 gagctggtgg aggaactcca ggtcagccgc agcaccctgc gccaggccgt ccaggccctg
    18781 gtgtacgtgg ggctgctgga gaccgcccag ggccggggga cgttcgtccg cggtacccac
    18841 gaggtcgaca cggtgctgca ccgctacctc gccgacgccg agctccgctc cgtactcgaa
    18901 acccggcgcg gcctcgaagt ggaggccgcc ggcctcgccg ccgagcgccg cagcgccgcc
    18961 gacctggacc gcctcgcggc cgtacacgaa cgccagacgg ccgctcagcg ggacggcagg
    19021 gccggcgagt tcagccgggc cgcggtggag ttccacacgg ccgtcgtcga ggcggcgggc
    19081 aaccccgtgc tggcccggct gtacggcacc atgctcggct ccgtacggga ctcggtccac
    19141 ctcggcggcg tgcgccgccc ccaggagcac tacggggacg ccgggcacgc gcgcatcctg
    19201 gaagcggtcc gccggggtga cccgcacgcc gcacggaagg cggcggccga acacgtcacg
    19261 accttcctca ccgccctcgc accgacggac aaggacatcc gatgacgccc ggccccaccc
    19321 cgtccgacgg ggctcagacc ctgttctccc gcgtcgccgt cttagcctcc tgcctgggca
    19381 tggtgatcat cggcgggctg ctcgccctgt acgggccggt ggtccccgcg ctgcgcgacc
    19441 gcttcggact ggccgagtcg acggccgggc tggcgctggc cgcccagtcg ctgggcgccg
    19501 tggtgggagt cctgggcttc cacgccatcc accgccgcat cggcaaccgc gccctgctca
    19561 ccgcctccta cctgaccatg ctggtgggaa ccgtcacctt cgcgctctgc ggggtgtggc
    19621 cgctgatgct ggcggcggcc gtcgtcacgg ggctcggcct cggcggcgtc gacttcgcca
    19681 tcagccgcct gttcctcatc ggcctcggtg cccgcggccc ggccttcctg aacgtggcgc
    19741 acggctgctt cggcctgggc accgtgctcg ctcccgccgc catcgccgtc atcggcccgg
    19801 aacactacgg cgccgcgttc atcgccctgg ggctgctgag cctgatcccg ctggcctgcg
    19861 tccgcggcat ccaggcccgc cccacccccg ccgaactcgc cgaggccgcc cccgcccccg
    19921 cgcaccacgc cggcgggcgc cgcctggccg ccgtgctcct cggtttcgtc gccatctaca
    19981 tgctgcactt cgccgtgcag agcggcatcg gcaactggga gcccacccac ctgcacgccc
    20041 tcggccacag catgaccacc gccaccgtcg cgacgtcgat gtactggctg gccatgaccg
    20101 tcggccgctt cctggtcgcg ccgctcgccc gccgctggtc ggcgcccacg atcgtcaccg
    20161 cgtcgtgcgc cctgatgagc gtcagcatcc tgctcgtccc ggtgcccgga ctcgccccct
    20221 gggcgtacgc cgcggccggg ctgtgcatcg gcccgatctt ccccaacggc ctgaactggc
    20281 tgaaccgttc cgctcccgcc tccggcaacg ccatggccta tgtcatcgcc gcggccatgc
    20341 tgggctccgt cgccttcccg cccgtcctgg gcgcggtcat ccagtcgcag ggcgtcggcg
    20401 ccctcccggt caccctggcc ggcctctgcc tgctcaccgt ggccgtcagc gccgtactcg
    20461 ccgtgcgtct tcgcggcacc ggagccgcga ccacggtgca tcaggagcag ccgacgacac
    20521 ccgccgcacc caccgcgccc gccgcgcggc agcaggacat gactctcacc ccccagaaga
    20581 aggacgcatc atgacgaagc agtgggtggc cggattccgc accgcggtga tcagcccgta
    20641 cgaggagacc aagctcagcg agccgcgcgg cttccacgac cagaccgtgc gccaggtact
    20701 gcacatggcc ggcggcggcg accggatccg cgtccggctc tccaaccgct acggccgcac
    20761 tcccctggcc gtcgccgacg cccgggtggc cgagcgcaag aacgccgacg agatcgtcac
    20821 cgagaccgac accggcctgc gtttcgaagg ggccgggcag gtgacgatcc ccgcgggcgg
    20881 cgaggccgtc agcgatcccg tcgacctgtc cgtgcggggc ggctcggacc tcgtgctcag
    20941 cttccacctg ccgcacgaca ccggcctggc cacctactcg cacatgccct ccgagctcgc
    21001 ctacgtcgtc agcggcaacc aggcgggcgc cgcggccctc cccggagcgg agcaggtcca
    21061 cgggcggttc tacgtgaccg gtgtcgacgt cctgaccgac ggcgacgcgc cggtcgccgt
    21121 cgcgttcggg gattcctggt tcgagggcgt cggcaccacc cacagcgcca accagcgctc
    21181 cgtggacatc ctcaaccggc gcctgggaca cggctgggcc gtcaaccagg gcatcgcggg
    21241 caaccggctg ctcaccgacg agatcggcga gcacgccctc gcacgcttcg aacgggacgt
    21301 cctggccgtg cccggcgcga cccacgtcct gctcaacttc ggcatcaacg acctgggcct
    21361 gcccggcatg ctcggcctgc cccccgccac cgccgacgac ctgaccgccg gcttcaccga
    21421 actcgcccgc cgtgcacacg acgcgggcct gacggtccac gcggggacca tcggcccgtt
    21481 cgccggtgcc gtctaccccg gccacaacac ccccgagggc ctcgccacac gacgccaggt
    21541 gaacgactgg atccgctcca gcggcacctt cgactcggtc ttcgacgtcg cacccgccgt
    21601 ggccgacccc gaccggccgg actacatccg cgccgagttc gactgcggag acggcatgca
    21661 cctcaacgac gccggagcac gggcgatggc cgaaaccatc gacctcgacg cgctcggccg
    21721 cccgcacccg ggggccgcgg ggcggtgacc gccgacgcgt ccggcagacg gcggcgcacc
    21781 gcggtggccg ccgtcctccg gcccgtcaca ccgcccgcat ccggaagtcg tagcgttccg
    21841 ggagcgggtg ttccgtgcgg gccttggtgc gggcggcttc ggtgaggggg gcggagcccg
    21901 ctgtgagccg ttcggcgacg gcgtaccagg tgtcgctgag gacttcgtcg ccttctcgca
    21961 ggtcggggac ctcgaagccg tggtcgaaga cggcgcgggc cgcggcggcg tcgccctcgg
    22021 cgagggccac ttgggcggtc agcagggcga ggcggccgtc ggtgcgggtg gccggaggca
    22081 ggcggtcgag ggcggcagcc gcctcgccgg ggcggcgggc ggcgagcagt gcggggaccg
    22141 ccgcgcgtac cagggccggg aggagcgggg cgatgtgctc cgtggcgtcc gcgggaccgt
    22201 cgtcgggtac gcaggccagg gcctccgcgt agcgttgcgc ggcgcgtgcc gtctcgcctg
    22261 cggtctcctc ggcgacggcg aggcagtaga gggggcggca gtccgtgccg tgggccaggg
    22321 cccgttccca gctgcggacg gcctgggccc ggtcgcccgc gtgccactgc gcgatgccga
    22381 ggtggaggtc ggtgcccggt ccgggcggcg cggactccag caggtcgcgc cacggcgcgg
    22441 agaccagggg cgcgacgggc acaccgctgc cgcgcgggaa gtcgccggtg tgcagcagcg
    22501 ccagccaggg gtgctggtcg gggccgaggg tggactcggc gaagggcgtg ccgggcaggt
    22561 cgtggccggt gcgggcccgt tccagggcgc cccagccgga gccggtggcc agcgtctcct
    22621 tcgggtcggc atcggcgtac ggccgccagg cggcgaaggc cgcgtcgacc tccgcacgcg
    22681 gcagtcgcgc ttcgagccgg tcgccggcct cgcggcgggc ggctgcccag tccccgccgt
    22741 gcaccacggc ggggtcggcg gcgagcggcc cgtacgcctc cagccaggcg aactccgtgc
    22801 cgccttcgag gcgtacgtgc tccagctgcg tacgggccag gcccgcctgg atctccgcgt
    22861 agccgccggt gccgggttcg gtgagccact gctgccagcg gcgcccggcg cggcccgcgc
    22921 cccacaggaa cagcttgcgg ccgcgcagcg tgtcggtgga ggtgtggacc aggccgtggc
    22981 cggtggcgtc gagcgaggcg atccagcggc ggtcgccgtc cgggatgccg tagaagtagt
    23041 cggcggggaa ctcgctgcgc agcgggtacg tgcggtcggt accgccggac tccggtacgg
    23101 ggacgtggcg cagcgtgtgc tcgtaaccga agtgccaggc ctcgtccgcc ggggcgagga
    23161 cgcgggtgtg ctcgtcctcg gggacggcga tgttggacca ccagtagacg ggggccgcgt
    23221 gcaggtgcgg gttgcggatg cggacgcctg cgtacaggaa gtcggagcct tccggaagcc
    23281 agaggtccac ttggaaaggg aggttgcgca ggcgttccca ttcccacagg cgcagcatct
    23341 cgccgccgtc gggcgccggt acggacgcgg cgtgcaccgg ggcgcaggac agggtggtgt
    23401 gtccggtggc gccggtgttc cactcgatgc cgccggagaa ccaggcgccg ttcagggcga
    23461 agttcgcggg ctgcagcacg gggttgcggt agagcagttc gcggccggtg ggcttgtggt
    23521 ggagggagtg cacccggccg ccgaggccgg gcaggacggt ggcgcgcagc cggtcgttct
    23581 cgatgacgag cgcgtcgagg gtggtttcgg tgcgcgtacg gccgtagccg tcgcggatgc
    23641 cgacgggcag cagggagtcc agcggcgcgt aggtgagctg gcgggccatg tcgggcggca
    23701 ggtcctggcc cgcgggcagc tcgacgcggt ggatgtcgcc cggtgcgcgg acggcgggca
    23761 gcgggctggc cgggccgacg ggtgctgcgg ggagggtcag ggtcgtccgt cgtacgctcg
    23821 tggccacggc tgcctcgcaa ggttgtaccg ggccacctcg ggtgcggtgg ccgcctgttg
    23881 accatggaac cctgtcggcg cccgcctgaa cagggcctgt tgaggccagg tatgcggccg
    23941 aatacggtca aaatcgtcct gggagaggcc ggcgggagtc agggctgtgg gacccggttt
    24001 gcacatcgac cagacgatca tcaacaagta ggtagggcat gaacgatctc gacaccttgg
    24061 cagcatttcc ggcaacagga gaactcggcc cggtcctgaa cgactgggag gaagccgaga
    24121 cggttctggg caccacgctc ccacctgcct tcaaggcgtt tctcagagtt ttcgggggat
    24181 caaagttcga tgacttcctg cgtgtctacc gggcaggcgc tgagaacgag catgtgaacc
    24241 tggtagccat gacgcttgca gcacggaaga cgatggagga ttcgcgcccc cacatccgtg
    24301 cccttctgga agagcgcgca gtacagcctt cacagctgat ccgctgggga ggcaccgaca
    24361 acgcggatat gtgcttcctg gtaccccaca ccgatccgga ccgctggtcc gtcctcaccg
    24421 tcatcggccg tggcagggag tacgacctct acgaaggacc ggtggagagc tacctgctga
    24481 acgtccttcg tggtgacctc gtcagtgacg tcttccccga ggacttccct gacgaagacc
    24541 cgggctacga gcgcaacccc tggatctgag ccgaggacag taataccggt cctggtccgc
    24601 agagccgccc cgcctagggc gtttccttcg gatcatctgg ctgaccagat gaagatggcg
    24661 gcgaggtgga gcccggcgag gtagatggtc gaggtcttgt cgtagcgggt ggccaggccg
    24721 caccactgct tgagtcggtt gatgcaccgc tcgacgacgt tgcgctgttt gtatgcctcg
    24781 tgatcgaagg ccggtggacg accgccgcgg ttgccgagtc gtttgcggtt ggcggcctgg
    24841 tcggcgggtt gcgggatcac cgtccggatc ccgcggcgct gtaggtgacg gcggatcacc
    24901 cgggacgagt acgccttgtc cgccaggtcc acggacggtg ccgtgcgcgg tctacctgcc
    24961 ggggcactct gatccgggcc atgacctgct cgaatgcggg tgcgtcatgg gcctgtccgg
    25021 ccgtgatgac gaacgcgagt ggccggcagc ggccgtcggc ggcgagatgg gttttcgtgg
    25081 ccagcccgcc gcgggagcgt ccgagggcat ggtcggccga ctcgccggcc ggggcccctt
    25141 ttgacgggcc ccggcggcgt gctggtgagc gcggacg
//
