LOCUS       NZ_LWKZ01000012        22292 bp    DNA     linear   CON 28-MAR-2024
DEFINITION  Streptomyces sp. CB02923 scaffold2, whole genome shotgun sequence.
ACCESSION   NZ_LWKZ01000012
VERSION     NZ_LWKZ01000012.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CB02923
  ORGANISM  Streptomyces sp. CB02923
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 1352816)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1352816)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra,H. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-APR-2016) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2016
            Assembly Method                   :: CLC NGS Cell v. 8.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905005.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:56:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,128
            CDSs (total)                      :: 8,049
            Genes (coding)                    :: 7,904
            CDSs (with protein)               :: 7,904
            Genes (RNA)                       :: 79
            rRNAs                             :: 2, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 145
            CDSs (without protein)            :: 145
            Pseudo Genes (ambiguous residues) :: 0 of 145
            Pseudo Genes (frameshifted)       :: 32 of 145
            Pseudo Genes (incomplete)         :: 128 of 145
            Pseudo Genes (internal stop)      :: 11 of 145
            Pseudo Genes (multiple problems)  :: 22 of 145
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:21:38
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1034632
            Orig. end                         :: 1056924
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LWKZ01000012.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22292
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="5"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22292
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22292
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12292](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12292)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(602..865)
                     /locus_tag="A6A06_RS16210"
                     /old_locus_tag="A6A06_10670"
     CDS             complement(602..865)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025006.4"
                     /locus_tag="A6A06_RS16210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_10670"
                     /product="carboxypeptidase-like regulatory
                     domain-containing protein"
                     /protein_id="WP_073761866.1"
                     /transl_table=11
                     /translation="MAVISGVVMDTDGRPVPDARVYLAAGPGSFPDVAALTDGEGRFVL
                     SAGADGGYTVECRSERGGASQTAGTAVTVRGGSADPVEIRLV"
     gene            complement(952..1881)
                     /locus_tag="A6A06_RS16215"
                     /old_locus_tag="A6A06_10675"
     CDS             complement(952..1881)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003983423.1"
                     /locus_tag="A6A06_RS16215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_10675"
                     /product="endopeptidase"
                     /protein_id="WP_073761867.1"
                     /transl_table=11
                     /translation="MPIEFHTAVSNEPEEQQVVFTAEELAVQPPSEGPQGDPAKATGDG
                     LENVRGYSRPEGTPEQLWQPPTAALPDIGEASFGPPPVAAETVHGPDDRVQITDTSVYP
                     WRVHCSLLITAADNSRWIGTGWFIGPHTLATAGHVVYIKNSGVAGRDGWVKSINVMPGR
                     NGNTLPYGVVTSTSFRTVNGWANNGDENYDYGAIITPTNLGNTTGWFGFGVWSDADLLK
                     TVGNISGYPGDKPAGTQWYDARGVASVGPRKVYYDIDTAGGQSGSSVYHFYNGGRYGIA
                     IHAYGGAVTNSGTRITTPVYNNYVSWKA"
     misc_feature    complement(2094..2110)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 21.67"
                     /tool="antismash"
     gene            2427..3368
                     /locus_tag="A6A06_RS16220"
                     /old_locus_tag="A6A06_10680"
     CDS             2427..3368
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003983424.1"
                     /locus_tag="A6A06_RS16220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_10680"
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="WP_073761868.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 1.9e-21, bitscore:
                     73.1, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 8.1e-10,
                     bitscore: 34.9, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTLRIGLLGTGPWAQRVHAPALAAHPGVTFTGVWGRRPEAAEA
                     LAASHGTRPYATPADLFADTDALAIALPPAVQADLAVRAAEAGRHLLLDKPVATSVPEA
                     RAVADAADRAGVASVVFFTARFGAAEGEWIDRAAAAGGWFTAHADWLGSVFAADSDSPY
                     AASPWRREKGALWDVGPHALSLLLPILGDAEQVTAARGPGDTVLLTLRHTSGAASSATV
                     SLTAPSAASGVSVTLYGSSGTTSLPRRQDGPEVAYARAVDALLTAVRSGERHPCDARFG
                     LRVTEVLAAAEASFEGAGRSGGPGRGDAPPLT"
     gene            complement(3361..3834)
                     /locus_tag="A6A06_RS16225"
                     /old_locus_tag="A6A06_10685"
     CDS             complement(3361..3834)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003983425.1"
                     /locus_tag="A6A06_RS16225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_10685"
                     /product="hypothetical protein"
                     /protein_id="WP_079194040.1"
                     /transl_table=11
                     /translation="MRSNMLFGGVYGTVLASALLAALQSEGTPFTPVYDALWVLVTAAT
                     AALAHGYAHHMSTHRGHSAGHRWHALGHRLIDEWPLVVASLPTVVLLLAAGGWGWPEGP
                     TTAAGLTLNATLLFGWGVAAALRMGYRRRGAVLIGVADAALGLLIAVANALIK"
     gene            4150..5727
                     /locus_tag="A6A06_RS16230"
                     /old_locus_tag="A6A06_10690"
     CDS             4150..5727
                     /NRPS_PKS="Domain: AMP-binding (14-416). E-value: 5.9e-80.
                     Score: 260.8. Matches aSDomain:
                     nrpspksdomains_A6A06_RS16230_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003983427.1"
                     /locus_tag="A6A06_RS16230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_10690"
                     /product="AMP-binding protein"
                     /protein_id="WP_073761869.1"
                     /sec_met_domain="AMP-binding (E-value: 1.5e-84, bitscore:
                     280.1, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAFTSYVESILQELADHPERRVLTTSEGRHITAADFHDSVHRTA
                     AELADRGIRRGHTVSMLSGNRPEALSARYAANLLGARIVLLYEGQAPETQARVVESAET
                     ALLLVGPESAKPAAELLSHLDGAAPDVLLLGPGGSGLDAEDLTAAAAARPSGRTVESAA
                     RPDDDWCIRYTGGTTGVPKGIQMAHAPYAKAVAYPFESAGDPPRLLACTSLAHLAGQMS
                     DMTLAAGGSVVLQDTFDTGAVLAAVARERITHMWLLPPLLYHLLDHPDLATTDLSSLTR
                     ITYGGCPASPSRLQQGLDVLGPVLYGWYGQSEALLLTEMGPAEHGRTGQGGQITVGRPV
                     PGVDIEVRDEHGHPLPPDTSGEVYVRSEGMMTGYWKKPELTAQVIRDGWVRTGDIGYLD
                     DAGYLYLMDRVKDMVIVVGGHVYPGELEDLLHTHPDIAHCAVFGVRTADEVEEVHCAVV
                     PAPGRTVDPGRITDFVVAHKGAMYAPSGVHQVDVIPLTSVGKPDKKRLKAELVEGKGEG
                     EGKGKGMG"
     aSDomain        4192..5397
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A6A06_RS16230_AMP-binding.1"
                     /evalue="5.90E-80"
                     /label="A6A06_RS16230_AMP-binding.1"
                     /locus_tag="A6A06_RS16230"
                     /protein_end="416"
                     /protein_start="14"
                     /score="260.8"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="LADHPERRVLTTSEGRHITAADFHDSVHRTAAELADRGIRRGHTV
                     SMLSGNRPEALSARYAANLLGARIVLLYEGQAPETQARVVESAETALLLVGPESAKPAA
                     ELLSHLDGAAPDVLLLGPGGSGLDAEDLTAAAAARPSGRTVESAARPDDDWCIRYTGGT
                     TGVPKGIQMAHAPYAKAVAYPFESAGDPPRLLACTSLAHLAGQMSDMTLAAGGSVVLQD
                     TFDTGAVLAAVARERITHMWLLPPLLYHLLDHPDLATTDLSSLTRITYGGCPASPSRLQ
                     QGLDVLGPVLYGWYGQSEALLLTEMGPAEHGRTGQGGQITVGRPVPGVDIEVRDEHGHP
                     LPPDTSGEVYVRSEGMMTGYWKKPELTAQVIRDGWVRTGDIGYLDDAGYLYLMDRVKDM
                     VIV"
     CDS_motif       4657..4713
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A6A06_RS16230_0001"
                     /evalue="2.10E-05"
                     /label="NRPS-A_a3"
                     /locus_tag="A6A06_RS16230"
                     /protein_end="188"
                     /protein_start="169"
                     /score="17.3"
                     /tool="antismash"
                     /translation="CIRYTGGTTGVPKGIQMAH"
     CDS_motif       5215..5298
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A6A06_RS16230_0002"
                     /evalue="1.20E-06"
                     /label="NRPS-A_a6"
                     /locus_tag="A6A06_RS16230"
                     /protein_end="383"
                     /protein_start="355"
                     /score="20.8"
                     /tool="antismash"
                     /translation="PPDTSGEVYVRSEGMMTGYWKKPELTAQ"
     gene            5923..6681
                     /locus_tag="A6A06_RS16235"
                     /old_locus_tag="A6A06_10695"
     CDS             5923..6681
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971612.1"
                     /locus_tag="A6A06_RS16235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_10695"
                     /product="response regulator transcription factor"
                     /protein_id="WP_073761870.1"
                     /transl_table=11
                     /translation="MTRVLLIEDDPAVRKGVLLALRRRGHEVETAASGETGLLALDRFR
                     PELVLLDLMLPGMSGLEVCRRIRETQQIPIIILSARGDDIDMVVGLEAGADDYVVKPAG
                     GEVLQARMRAVLRRVVGEGRGDGAAREAGAAPGPSGAATPSPSAPSPHASTRYGALTVD
                     RAALLVTKDGHEVVLAPSELKLLLFLSDSPGQVFSRQQLLEQVWEHSFYGDVRLVDACV
                     MRLRSKIEDDSRAPAYVQTVRGFGYRFGPL"
     gene            6678..8606
                     /locus_tag="A6A06_RS16240"
                     /old_locus_tag="A6A06_10700"
     CDS             6678..8606
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014145452.1"
                     /locus_tag="A6A06_RS16240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_10700"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_242440762.1"
                     /transl_table=11
                     /translation="MSPRPPRGGSTRTRGRERLAAAYTRLRGLRTRLIVGFLVVSALSA
                     LITATLTFRQARTAILARTQDTAVHDLRAQMESLGPDLPFPPRREDLQNLVVQLDRAGG
                     SRNWHTYAQYEDAPVVPEPWRGDGGKAGRVDAGEAGRVDGGEAGRVDGGAPGDADSRAP
                     GDVDGGVQGGAQGGAMSRAPGDADSGAQGGARSGAPGDTSSRALGREPGSAVTDGLRAA
                     VRDHHAPIFQRVDRGGQPWLAIGMPVDFTDPAAGAGAPSASPPSSSPSASPSSSPRGNK
                     PSGLVVYAEFALDDEQADISALVTAAQAGALPALALAVVPALFAARRVLLPVRRLREAA
                     ERITSGELDTRSPVTGRDELADLTVTFNDMARALEKDDAELRRMEANARRFAADVSHEL
                     RTPLAAMAAVTEVLDEDAARLDPDTADAVRLISNETTKLARMVEDLIEVSRFDAGAADL
                     LLDEIDVAVALRKTLQLRGWQDRVETGLPEELRARLDPRRIDVVVANLVGNALRHGGAP
                     VRVTAYETTGRLRIDVADRGPGINPEALPHVFDRFYKADAARARSSGSGLGLAIAMENV
                     RLHGGTLSAANAPGGGAVFTVDVPLDPPTEPAPGPHPTSPGPESGSHRTSPGPDPDRHP
                     TSPEDRP"
     gene            8603..9265
                     /locus_tag="A6A06_RS16245"
                     /old_locus_tag="A6A06_10705"
     CDS             8603..9265
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003983429.1"
                     /locus_tag="A6A06_RS16245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_10705"
                     /product="GerMN domain-containing protein"
                     /protein_id="WP_073761871.1"
                     /transl_table=11
                     /translation="MRSRTPPTPTTPSDLRLRLHPRSLFPLSLITALLLTTALLLTGCG
                     ITPTGYVQAGAPAQGARQPGTDTYTARIFFLSPLGVRAAARPTDGPVGPQEALDMLVKG
                     PTAAEQARGLVSEVPPTSGRLTAVPATGAVSVFLPTPVSRMEAVAVHQIACTAAHADIP
                     GGRPATQVDVRMYEPKSQGTPWTVRCSSNGIALPTAGPDTWQNPAPRASPRPAPDTS"
     gene            9483..9713
                     /locus_tag="A6A06_RS16250"
                     /old_locus_tag="A6A06_10710"
     CDS             9483..9713
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009720544.1"
                     /locus_tag="A6A06_RS16250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_10710"
                     /product="hypothetical protein"
                     /protein_id="WP_199930935.1"
                     /transl_table=11
                     /translation="MVKKSLPAGLPREWYEAHNRRLKAMRLAIALLDGGVYTPERARNR
                     TIRTTAARIGVHPPSNTTCRLVRSLIIENAR"
     gene            complement(10001..12292)
                     /locus_tag="A6A06_RS16255"
                     /old_locus_tag="A6A06_10715"
     CDS             complement(10001..12292)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014158016.1"
                     /locus_tag="A6A06_RS16255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_10715"
                     /product="germacradienol/geosmin synthase"
                     /protein_id="WP_338015907.1"
                     /sec_met_domain="T1TS (E-value: 4.9e-79, bitscore: 262.8,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNAHLEGARRHSKEWARGMGMVEGSGIWEERDLDAHDYALLCAYT
                     HPDCSADALALVTDWYVWVFFFDDHFLEAFKRTQDRVGGKAYLDRLPLFMPMDLDTPVP
                     APVNPVEAGLADLWARTVPSMSEGWRARFRESTEHLLNESLWELSNINAGRVPNPVEYI
                     EMRRKVGGAPWSAGLVEFAAGAEVPAAVAGSRPLRVLKDTFSDGVHLRNDLFSYQRETE
                     EEGELSNSVLVLENFLGCTTQESADAVNDLITSRVQQFENTVLTELPVLFAEKGLSPQE
                     CADVLAYAKGLQDWQSGGHEWHMRSSRYMNGGGKAAESAGGWSPFAFGGLGTSGMDVRR
                     ALAVTGAKRVRNFTHVPFRKVGPSQLPDFYMPFTTTLSPHLDGARVNAVEWARQMGMFR
                     PQAGVPLSDVWDAGKVTDYDFPLCAAGLDPEATPEELDLGSQWLTWGTYGDDYYPAVFG
                     AVRDLTGAKACNVRLSAFMPVEDGEAMPEPANAMERGLADLWRRTTESMDAAARKTFRD
                     SVEVMTAGWIWELENQALHHIPDPVDYIEMRRATFGSDMTMSLSRIGHGRRVPQEIYRS
                     GPMRSLENAAADYATLLNDVFSYQKEIEYEGEVHNGVLVVQNFFDCDYPTALAIVHDLM
                     TSRMREFQHVAANELPVLYDDFELPEEARALLDGYVKELENWMSGILTWHQECRRYREE
                     DLRRHKGVADMPAGAGAGNEAPLGTWSGRPTGLGTSAARVAQQATETATEMETAKETAK
                     ETVTAAAGVA"
     misc_feature    complement(12340..12358)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 19.9"
                     /tool="antismash"
     misc_feature    12382..12396
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 23.18"
                     /tool="antismash"
     gene            complement(12627..13208)
                     /locus_tag="A6A06_RS16260"
                     /old_locus_tag="A6A06_10720"
     CDS             complement(12627..13208)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009721032.1"
                     /locus_tag="A6A06_RS16260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_10720"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_242440763.1"
                     /transl_table=11
                     /translation="MPEIRPETRRADARRNYARILAVAEEEVAAHGADASLEQIARTAQ
                     VGSATVRRHFPTRRALLEAVAGKRIEALCVRARDLADRPDSRAALLEWLSDVIAYCVTA
                     RGLAPALAYDSTGADDPAYENSCSAPLEEAAAPLLRRAVEDGAVAPEFTVADLITLAVG
                     LTLATEHHLDPAAAADRLFRLTVAGLSPRS"
     gene            13313..14251
                     /locus_tag="A6A06_RS16265"
                     /old_locus_tag="A6A06_10725"
     CDS             13313..14251
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019435922.1"
                     /locus_tag="A6A06_RS16265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_10725"
                     /product="NmrA/HSCARG family protein"
                     /protein_id="WP_073761873.1"
                     /transl_table=11
                     /translation="MSTAPTSTPPSPVLVTGATGRQGGATVRALLAAGAPVRALVRDAA
                     TDRAKAVAALGAELVTGDLHDRESVIRAAEGVRAVFSVQMPAFTAEGPDFDGEVAQGVN
                     LVEGAKAAGVRQFVYSSVSGAGRHTEAPGWDEERFGFMNPAMGTKAAVQDRVREAGFPH
                     WTLLKPGFFMENFLPSLAYMFPRGIEGGLVTLLRPETRLSLAAVDDIGAAAAAAFAAPE
                     RFDGVELELASDYLSMTEIAGTLSRVLGRDVPAPDMTEEEAVAAGMPAMGRSHLWLNAT
                     GQPARPEYAKDLGIPLTTFEEWARKYMRPGA"
     gene            complement(14308..14904)
                     /locus_tag="A6A06_RS16270"
                     /old_locus_tag="A6A06_10730"
     CDS             complement(14308..14904)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003979215.1"
                     /locus_tag="A6A06_RS16270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_10730"
                     /product="hypothetical protein"
                     /protein_id="WP_073761874.1"
                     /transl_table=11
                     /translation="MTLRRALSLSAATAALLPMAVAAAPASQAAPAPAADLPKCSDVGQ
                     PHNNTFVGRSFGIPKSITLGTHWTTYTATLTNASAKELKSFELSGKLGSYVYNEGERDL
                     SPYGDLQYWDTSQRAWKTLRQANGNAGGTIPAPKTLKPRESVHVQLRFRVSTDLPLDHD
                     YDAFTGLTGTFADRYQGTDCTARGDADGGFSPRKG"
     gene            complement(15044..16117)
                     /locus_tag="A6A06_RS16275"
                     /old_locus_tag="A6A06_10735"
     CDS             complement(15044..16117)
                     /GO_component="GO:0009986 - cell surface [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016573832.1"
                     /locus_tag="A6A06_RS16275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_10735"
                     /product="LPXTG cell wall anchor domain-containing protein"
                     /protein_id="WP_073761875.1"
                     /transl_table=11
                     /translation="MRIRRALTAAAAAAVIAPAAVLAVPAAAFATEPVSESGPRTPASS
                     PGSPDGPAAQDRDGAARPAAQVQPPKAAGAAEEAKGSTRAGGAIGGGKDAGDDDGAEQS
                     CAFESGQLNVAVHGLPPRLTAGGAWVPFSLTLTNTTGTSLEEVQPFLAVSSAEDVDRPY
                     WELETEYRDAKTGQWKSFHDAAPEELFGFFAVGPRGTVTLQLRTRAVKDAKPGAGYALA
                     AGDYRNRDGSCGSSKEAWYDFTILPAGAKPTQPPTAEPSEPGKPGKPGGTADPTPTAEP
                     SRSAAPGGGTGGSGSAGGLSAQGGAQLAATGSSSALPAIALAGGAAMAVGAGAVIGARR
                     RKGAAGSGATDVTDVIA"
     gene            complement(16495..17904)
                     /gene="glnA"
                     /locus_tag="A6A06_RS16280"
                     /old_locus_tag="A6A06_10740"
     CDS             complement(16495..17904)
                     /EC_number="6.3.1.2"
                     /GO_function="GO:0004356 - glutamine synthetase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006542 - glutamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="glnA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003976617.1"
                     /locus_tag="A6A06_RS16280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_10740"
                     /product="type I glutamate--ammonia ligase"
                     /protein_id="WP_073761876.1"
                     /transl_table=11
                     /translation="MFQNADEATKFIADEDVKFVDVRFCDLPGVMQHFTVPAEAFDPTE
                     ELAFDGSSIRGFQAIHESDMALRADLSTARVDPFRRDKTLNVNFFIHDPITGEQYSRDP
                     RNVAKKAEAYLASTGIADTAFFGPEAEFYVFDNVRFETSANQSFYHIDSEAGAWNTGSE
                     INNRGYKVRYKGGYFPAPPVDHFADLRAEISLELDAAGLKVERQHHEVGTAGQAEINYK
                     FNTLLAAADDLMLFKYIVKNVAWRNGKTATFMPKPIFGDNGSGMHVHQSLWTGGEPLFY
                     DEQGYAGLSDTARYYIGGILKHAPSLLAFTNPTVNSYHRLVPGFEAPVNLVYSQRNRSA
                     AMRIPITGSNPKAKRVEFRAPDPSSNPYLAFSALLLAGLDGVKNKIEPAEPIDKDLYEL
                     APEEHAGVPQVPTSLPAVLDALEADNEYLQQGGVFTSDLIETWIDYKRTNEIAPIQLRP
                     HPHEFELYFDI"
     misc_feature    18027..18044
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.5"
                     /tool="antismash"
     gene            18267..18734
                     /locus_tag="A6A06_RS16285"
                     /old_locus_tag="A6A06_10745"
     CDS             18267..18734
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003969589.1"
                     /locus_tag="A6A06_RS16285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_10745"
                     /product="RDD family protein"
                     /protein_id="WP_073762208.1"
                     /transl_table=11
                     /translation="MDNRQAIGSWISGPRAAAEDMGVEFGYRGQQLGLPAEGPGSIARP
                     GRRFAALFVDWALCTLVAYGLLSHGRADSTSNWALAVFVVLSVLTVGTVGFTPGKRLLG
                     LRVVAEGGGRLPLLRVVLRTVLLAVVIPAVIWDRDGRGLHDRLARAVQVRI"
     gene            complement(18977..19690)
                     /locus_tag="A6A06_RS16290"
                     /old_locus_tag="A6A06_10750"
     CDS             complement(18977..19690)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018511895.1"
                     /locus_tag="A6A06_RS16290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_10750"
                     /product="DUF4191 domain-containing protein"
                     /protein_id="WP_073761877.1"
                     /transl_table=11
                     /translation="MARKAKADSAEGAANPGRLKQIAQTYKMTRRVDPKVGLVVAGVGI
                     VVFGVLLALGFLIGHPVYAGILGFVLAFLAMAIIFGRRAEKAAFGQMEGQPGAAAAVLD
                     NVGRGWTITPAVAMNRQQDVVHRAVGKAGIVLVGEGNPNRVRGLLAAEKKRMARIVADA
                     PVHDLVVGEGEGQVPLKKIRTTLLKLPRTLPGAQVTAVNDRLRALGDLMSNMPVPKGPM
                     PKGMRMPKGGGGKMR"
     gene            complement(19701..19919)
                     /locus_tag="A6A06_RS16295"
                     /old_locus_tag="A6A06_10755"
     CDS             complement(19701..19919)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003983437.1"
                     /locus_tag="A6A06_RS16295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_10755"
                     /product="hypothetical protein"
                     /protein_id="WP_073761878.1"
                     /transl_table=11
                     /translation="MQAAPARATAALPIPSVTDALRAVESVLMRGGQRTARRNAWTSVL
                     EDRRRARDRHEAQHVLEAAATEGPNAT"
     misc_feature    complement(20005..20020)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.31"
                     /tool="antismash"
     misc_feature    20092..20107
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.67"
                     /tool="antismash"
     gene            complement(20183..21133)
                     /gene="lipA"
                     /locus_tag="A6A06_RS16300"
                     /old_locus_tag="A6A06_10760"
     CDS             complement(20183..21133)
                     /EC_number="2.8.1.8"
                     /GO_function="GO:0016992 - lipoate synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0009107 - lipoate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="lipA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016572046.1"
                     /locus_tag="A6A06_RS16300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_10760"
                     /product="lipoyl synthase"
                     /protein_id="WP_073761879.1"
                     /sec_met_domain="PF04055 (E-value: 7.5e-14, bitscore: 48.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAVAPDGRKMLRLEVRNSQTPIERKPEWIKTRAKMGPEYNHLQG
                     LVKKEGLHTVCQEAGCPNIYECWEDREATFLIGGDQCTRRCDFCQIDTGKPQELDRDEP
                     RRVAESVQTMELKYATITGVARDDLDDGGAWLYAETVRQIHAAMPDTGVELLIPDFNAV
                     PEQLAEVFSSRPEVLAHNVETVPRIFKRIRPGFRYERSLEVITKAREAGLVTKSNLILG
                     MGEEREEISQALQDLHDAGCELITITQYLRPSVRHHPIERWVKPAEFVELKEEAEEIGY
                     AGVMSGPLVRSSYRAGRLYQQAIERRQVEGSAQAV"
     gene            complement(21314..22129)
                     /gene="lipB"
                     /locus_tag="A6A06_RS16305"
                     /old_locus_tag="A6A06_10765"
     CDS             complement(21314..22129)
                     /EC_number="2.3.1.181"
                     /GO_function="GO:0033819 - lipoyl(octanoyl) transferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009249 - protein lipoylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lipB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003983439.1"
                     /locus_tag="A6A06_RS16305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_10765"
                     /product="lipoyl(octanoyl) transferase LipB"
                     /protein_id="WP_073761880.1"
                     /transl_table=11
                     /translation="MTAISRGDTPTPEGLRFVQLGFGADAVDYETAWQEQRRVHAARFA
                     DEVPDTCLLLEHPPVYTAGRRTDDSERPLDGTPVIDVDRGGKITWHGPGQLVGYPIQKL
                     PRPVDVVAHVRRLEEAIIRTCTDFGVETSRVEGRSGVWVLGDPVADRPALGGLSLDFDP
                     RTADEEFDPRLNGPEYAPSNAGQRREDRKLAAIGIRVAKGVTMHGFAINVNPDNTSFDK
                     IVPCGIRDAGVTSLANELGRETTIADVLPVVEKHLRDVLENAVLLPRAV"
ORIGIN
        1 agcgccgtca gatgccccgc gtccgtgaag tcccgccgtc ggctcaggac cgggcgtacg
       61 cccagcacca gcagccccgc cgtggccgcg gcccgcgcac cgcggtgcgg cacggagacg
      121 gcgagcgcgc ccaccgtggc gtagaagccg taactcgcgc ccacgtccac ggcccgctcg
      181 atgtcggggg tgaccgcctt gtgggacagc gcgcgggccg cccgcagccc gccgtacacg
      241 agcacgctgg cgccgatgtg cccggcggcg aacgtaccgg cggcgcgccg ggtgccccac
      301 gccgcctcgg ccgtgccgag cgccgcgagc agcgcgatcc cgtacgggac gggcagcggg
      361 ctctcgacga acacggcgct ggtcgccagc gtccgccagc ggcccgcccg caggttgtcg
      421 acgttggtgg agtgcgcgcg cagcagctcg gcgcgttccc gcgcgggcag ccgcgcggtg
      481 gcgtacgcgc cgagctggac ggcgccgacg tacagcgggg cgaaccaggg agcacaggcg
      541 gagggtgctt tcatgccctc catcatccct ggcgggaccc ggggtccgcc gggagccggt
      601 gtcagacgag gcggatctcg accgggtcgg ccgacccgcc ccgcaccgtg accgcggtcc
      661 cggcggtctg cgacgcgccg cctcgctccg accggcactc gacggtgtag ccgccgtcgg
      721 cgccggcgga gaggacgaag cgcccctcgc cgtcggtgag cgcggccacg tccgggaagg
      781 agccggggcc cgcggcgagg tacacccggg cgtccgggac gggccggccg tccgtgtcca
      841 tcacgactcc ggagatcacc gccataccgg gacctttcgt ttcctcaggg ccgggtggtg
      901 ccaggccctt ccggcgtcag ggtgtacgga gccctgtacg ggtccgtacg gtcacgcctt
      961 ccacgacacg tagttgttgt acaccggtgt ggtgatccgc gtgcccgagt tggtgaccgc
     1021 gccgccgtat gcgtggatcg cgatgccgta ccggccgccg ttgtagaagt ggtagacgga
     1081 gctgccgctc tggccgcccg ccgtgtcgat gtcgtagtac accttgcgcg gaccgacgga
     1141 ggcgacgccg cgcgcgtcgt accactgcgt accggccggc ttgtcgcccg ggtaaccgga
     1201 gatgttgccg acggtcttga gcaggtcggc gtcggaccac acgccgaagc cgaaccagcc
     1261 ggtggtgttg ccgaggttgg tgggcgtgat gatcgcgccg tagtcgtagt tctcgtcgcc
     1321 gttgttggcc cagccgttga ccgtacggaa gctggtgctg gtgacgaccc cgtagggcag
     1381 ggtgttgccg ttgcggcccg gcatcacgtt gatgctcttg acccagccgt cgcgcccggc
     1441 gacgccgctg ttcttgatgt agacgacgtg ccccgcggtg gccagggtgt gcgggccgat
     1501 gaaccagccc gtgccgatcc agcgggagtt gtccgccgcg gtgatcagca gcgagcagtg
     1561 cacccgccac gggtacacgg acgtgtcggt gatctgcacc cggtcgtccg ggccgtgcac
     1621 ggtctcggcg gcgaccggcg gcgggccgaa ggacgcttcg ccgatgtccg gcagcgccgc
     1681 ggtgggcggc tgccagagct gctccggcgt gccttcgggg cggctgtagc cccgtacgtt
     1741 ctccaggccg tcgccggtcg ccttggccgg gtcgccctgc ggcccctcgg acggcggctg
     1801 tacggccaac tcctcagcgg tgaaaacgac ctgctgttcc tccggctcgt tcgagacagc
     1861 ggtgtggaac tcgatcggca ttgctggtca ccgggcctct cggttctcgc ggtgcactgt
     1921 gggagtcctc ctcgaaggag tcctctcctt gtactgcggt ccccggagcc ggacaacgaa
     1981 agatgcggcg aattcttgcg gatggccctc tgctacgtca tccgtcccga agtgccccgg
     2041 caacagcacg agacaccccg cgaaaacggg acgccccggc cacggagaac ttccgcaccg
     2101 agaacgggca cgaccggacc ttgcgggccg gtgcgggacg cgccacgacg cgcgcagcgg
     2161 gcgcgcgcgg gcgcgagagc gtccatgaga gggatgttgt gagtggggct ggggcgcggc
     2221 gggcgcgcgc ttcgcgagag cgtccgcgca gcgcggcagg ggaagcctgc ggtgcggacg
     2281 cgggggtgtc tgtggagcgg ggcggggcat ctgcggtgca gggacggggg accgtgctcg
     2341 cgttggcgga cacgtggcgt agtggcgacg cgaggcgcgc gggctcttac ggcggcaccc
     2401 ttgcgccgcg cggcacactg acggtcatga cgacgaccct gcgcatcgga ctcctcggca
     2461 ccggcccctg ggcacagcgc gtccacgccc ccgccctcgc cgcccacccc ggcgtcacct
     2521 tcacgggcgt ctgggggcgc cgccctgaag cagccgaggc gctggccgcg agccacggca
     2581 cccgcccgta cgcgaccccc gctgacctgt tcgccgacac cgacgccctc gccatcgcgc
     2641 tcccgccggc cgtccaggcc gacctggccg tacgggccgc cgaagccggc cggcacctcc
     2701 tcctggacaa gccggtcgcc acctccgtcc ccgaagcgcg cgcggtggcc gacgcggccg
     2761 accgggcggg cgtcgcctcc gtcgtgttct tcaccgcgcg cttcggcgcc gccgaggggg
     2821 agtggatcga ccgggcagcc gcggccggcg gctggttcac cgcgcacgcc gactggctcg
     2881 gctcggtctt cgcggccgac agcgacagcc cgtacgcggc ctccccctgg cgccgcgaga
     2941 agggcgccct gtgggacgtc ggcccgcacg cgctgtccct cctgctgccc atcctcggcg
     3001 acgcggagca ggtcaccgcc gctcgcggcc ccggcgacac cgtgctgctc acgctgcggc
     3061 acacgagcgg cgcggcgagc tcggcgaccg tcagcctgac cgcgccgagt gccgcctccg
     3121 gagtgtccgt cacgctgtac ggcagttccg gcaccacctc gctcccgcgc cgccaggacg
     3181 gtccggaagt ggcgtacgca cgcgcggtgg acgcgctgct caccgccgta cgcagcggtg
     3241 aacggcaccc ctgcgacgca cggttcggac tgcgggtgac ggaggtgctg gcagcggcgg
     3301 aggcgtcgtt cgaaggggcc ggaaggagcg gcgggccggg ccggggggac gcgccgcccc
     3361 tcacttgatc agcgcgttcg ccaccgcgat cagcaggccg agcgcggcat cggccacccc
     3421 gatgagcacg gcaccccgcc tgcggtagcc catccgcagc gcggcggcca cgccccaccc
     3481 gaacagcagc gtggcgttga gcgtcagccc ggccgccgtg gtggggcctt cgggccagcc
     3541 ccagcccccg gcggccagca gcagcaccac cgtgggcagc gaggcgacga cgagcggcca
     3601 ctcgtcgatc agccggtgcc cgagcgcgtg ccagcggtgg ccggcgctgt ggccgcggtg
     3661 ggtggacatg tggtgggcgt agccgtgcgc gagcgcggcg gtggcggccg tgaccagcac
     3721 ccacagcgcg tcgtacacgg gggtgaacgg cgtgccctcg ctctgcagag cggccagcag
     3781 cgcactggcg agcaccgttc cgtacacgcc tccgaacagc atgttggaac gcacgaaaag
     3841 ctctctttcc gcgatacggc aatggcgtaa cgagccgtcc acgttaattg gcggagccgc
     3901 tcctttcctc accgtaacgg gggagaaaga aatggccgaa ggtatgacaa cgcgtggcgg
     3961 caacggaaat cccgtacccg cggaacggac cgtcggcctt atgcctcccc gggtatcgct
     4021 acatgccgga attggtcttg gaaggcatga gagatcccgc ctaacgtcgg gtccgcgccc
     4081 ttcgcgctcc ccatccgcac gcactccgca ccgcgcgcca gtgcgctgta cgacaaggag
     4141 gcgcagctca tgacagcgtt cacgagttac gtcgaaagca ttctccagga actggccgac
     4201 cacccggaac gccgggtgct gaccacgtcc gaggggcggc acatcaccgc cgccgacttc
     4261 cacgacagcg tgcaccgcac ggccgcggaa ctggccgacc gcgggatccg acgcggccac
     4321 accgtctcga tgctgtccgg gaaccgcccg gaagccctgt ccgcccggta cgcggccaac
     4381 ctgctggggg ccaggatcgt actgctgtac gaggggcagg ccccggaaac ccaggcgcgc
     4441 gtcgtggaga gcgccgagac cgccctgctc ctcgtcggtc cggaatcggc caagcccgcg
     4501 gcggaactgc tctcccacct cgacggcgcc gcaccggacg tcctgctgct cggccccggc
     4561 ggcagcggcc tggacgccga ggacctgacc gccgctgccg ccgcccgccc ttcaggccgt
     4621 acggtcgaga gcgcggcccg ccccgacgac gactggtgca tccgctacac gggcggcacg
     4681 accggcgtcc ccaagggcat ccagatggcg cacgccccct acgcgaaggc ggtcgcctac
     4741 cccttcgagt cggcaggcga cccgccccgc ctgctcgcct gcacctcgct cgcccacctg
     4801 gccggacaga tgtccgacat gacgctggcc gccggcggca gcgtcgtcct ccaggacacc
     4861 ttcgacaccg gcgccgtcct cgccgccgtc gcacgcgaac gcatcaccca catgtggctg
     4921 ctgccgcccc tcctctacca cctcctcgac catccggatc tggccaccac cgacctcagc
     4981 agcctcaccc gcatcaccta cgggggctgc ccggcctccc cctcccggct tcagcagggc
     5041 ctcgacgtgc tcggcccggt cctctacggc tggtacgggc agtccgaggc cctgctgctc
     5101 accgagatgg gcccggcgga gcacggcagg accgggcagg gcggccagat caccgtcggc
     5161 cgccccgtac ccggagtgga catcgaggtc cgcgacgagc acggccaccc cctgccgccg
     5221 gacaccagcg gcgaggtgta cgtccgctcc gagggcatga tgaccggcta ctggaagaag
     5281 cccgaactga ccgcgcaggt catccgcgac ggctgggtac gcaccggcga catcggctac
     5341 ctcgacgacg ccggctacct ctacctgatg gaccgggtca aggacatggt catcgtcgtg
     5401 ggcggacacg tctatccggg tgagctggag gacctgctgc acacccaccc ggacatcgcg
     5461 cactgcgcgg tcttcggcgt gcgcaccgcc gacgaggtgg aggaggtgca ctgcgccgtc
     5521 gtccccgccc cgggacgcac ggtcgacccc ggccggatca ccgacttcgt ggtggcgcac
     5581 aagggcgcga tgtacgcacc gagcggtgtg caccaggtgg acgtcatccc gctcacctcc
     5641 gtcggcaagc cggacaagaa gcggctcaag gccgagctgg tggaggggaa gggggagggc
     5701 gaggggaagg ggaagggtat ggggtaagga ccggaatcgg gggaggggga gcggcgggga
     5761 ggccggatcg tgccggatcg tcggcctgcc ggagccgtca tcatttcctc acacaatgcg
     5821 agacacggcg tcacgaacag cgcgcaccat ggtcagctcc cgtccccgcc gtacgcttcc
     5881 gacgagcgtc cgcccggcca ccgcttcgga gaagaccgcc ccatgacccg tgtgctgctc
     5941 atcgaggacg accccgccgt acgcaagggc gtccttctcg cgctgcgccg ccgtgggcac
     6001 gaggtcgaga cggcggccag cggcgagacc ggcctcctcg ccctggaccg cttccggccg
     6061 gaactggtgc tgctggacct gatgctgccc ggcatgagcg gcctggaggt gtgccgccgc
     6121 atccgcgaga cacagcagat cccgatcatc atcctgtccg cgcgcggcga cgacatcgac
     6181 atggtggtgg ggctggaggc cggcgcggac gactacgtgg tcaagcccgc cggcggcgag
     6241 gtgctccagg cgcggatgcg ggcggtgctg cggcgggtgg tgggggaggg gcgcggagac
     6301 ggggcggcgc gggaggcggg cgccgctccc ggcccgtccg gagccgccac gccctcgccc
     6361 tctgcgccct cgccccacgc ctccacgagg tacggcgcgc tgaccgtcga ccgcgcggcg
     6421 ctcctggtca ccaaggacgg ccacgaggtc gtcctcgccc cttccgaact gaagctgctg
     6481 ctcttcctgt ccgattcccc cggccaggtc ttcagccgac agcaactcct cgaacaggtc
     6541 tgggaacaca gcttctacgg ggacgtgcgg ctggtggacg cgtgcgtcat gcggctgcgc
     6601 tccaagatcg aggacgattc gcgtgcgccc gcgtacgtac agacggtacg ggggttcggc
     6661 taccggttcg gccctctgtg agcccccgcc ccccgcgagg aggaagcacg cggacgcggg
     6721 gccgggagcg gctggccgcc gcgtacacca ggctgcgcgg tctgcgcacc cgcctcatcg
     6781 tcggcttcct cgtggtctcc gcgctcagcg cgctgatcac cgcgacgctc accttccggc
     6841 aggcccgtac ggcgatactg gcccgcacgc aggacaccgc cgtgcacgac ctgcgcgccc
     6901 agatggaatc cctgggcccc gacctgccct ttccgccccg ccgcgaggac ctgcagaacc
     6961 tcgtcgtcca gctcgaccgg gccggcggct cccgcaactg gcacacctac gcgcagtacg
     7021 aggacgcgcc ggtcgtcccg gagccgtggc gcggggacgg cgggaaggcg gggcgggtgg
     7081 atgctgggga ggcggggcgg gtggatggcg gggaggcggg gcgggtggac ggtggcgcgc
     7141 cgggggacgc ggacagccgt gcgccggggg atgtggacgg cggcgtgcag gggggagcgc
     7201 agggcggcgc gatgagtcgt gcgccggggg atgcggacag cggcgcgcag ggcggcgcga
     7261 ggagtggcgc gccgggggac acgagcagtc gtgcgctggg gcgtgagccc gggagtgcgg
     7321 tcaccgacgg tctgcgcgcc gccgtacgcg accaccatgc gcccatcttc caacgcgtcg
     7381 accggggcgg gcagccctgg ctggcgatcg gcatgccggt ggacttcacc gacccggcgg
     7441 ccggagccgg cgccccctca gcctctccac cttcttcctc cccctccgcc tctccttcct
     7501 cctctccccg ggggaacaag ccctccggcc tcgtcgtcta cgccgagttc gccctcgacg
     7561 acgagcaggc cgacatctcc gccttggtca ccgccgccca ggccggcgcg ctgcccgcgc
     7621 tcgcactggc cgtcgtcccc gcgctgttcg ccgcccgccg cgtcctgctg ccggtacgcc
     7681 gcctgcgcga agccgccgaa cgcatcacct ccggcgaact ggacacccgc tccccggtga
     7741 ccggccgcga cgaactcgcc gacctcaccg tcaccttcaa cgacatggcc cgtgccctgg
     7801 agaaggacga cgccgaactg cgccgcatgg aggccaacgc ccggcgcttc gccgccgacg
     7861 tctcccacga actgcgcacc ccgctggccg ccatggccgc ggtcaccgag gtcctcgacg
     7921 aggacgcggc ccggctcgac cccgacaccg ccgacgcggt gcgtctcatc agcaacgaga
     7981 ccaccaaact cgcccgcatg gtggaggacc tgatagaggt ctcgcgcttc gacgcgggcg
     8041 ccgccgacct gctcctcgac gagatcgacg tcgccgtcgc cctgcgcaag acgctccagc
     8101 tgcgcggctg gcaggaccgg gtcgagaccg gcctccccga ggagctgcgg gcccgcctcg
     8161 acccgcgccg tatcgacgtg gtcgtggcca acctggtcgg caacgcgcta cggcacggcg
     8221 gcgccccggt acgggtgacg gcgtacgaga cgacgggacg gttgcgtatc gacgtggccg
     8281 accggggccc cgggatcaac ccggaagccc tcccgcacgt cttcgaccgc ttctacaagg
     8341 ccgacgccgc ccgcgcccgc tccagcggca gcggactggg gctggccatc gccatggaga
     8401 acgtacggct gcacgggggc accctgagcg cggccaacgc gccgggcggg ggagcggtgt
     8461 tcacggtgga cgtaccgctg gacccgccga cggaaccggc ccccggccca caccccacct
     8521 ctcccggccc cgagtccgga tcacaccgca cctctcccgg tcccgatccc gaccgacacc
     8581 ccacctctcc cgaggaccgc ccatgaggag ccgcacccca ccaaccccga ccacaccctc
     8641 agacctccgc ctccgcctcc acccccgctc cctcttcccc ctctccctca tcaccgccct
     8701 cctcctcacc acggctctcc tcctcaccgg ctgcggcatc acccccaccg gctacgtaca
     8761 ggcgggcgcc cccgcgcagg gcgcccggca gccgggtacc gacacctaca ccgcgcggat
     8821 cttcttcctc tcgcccctcg gcgtccgcgc cgccgcccgc cccaccgacg gcccggtcgg
     8881 cccgcaggaa gccctggaca tgctggtgaa ggggcccacc gccgccgaac aggcccgtgg
     8941 gctggtcagc gaggtgccgc cgacgtccgg ccggctcacc gccgtccccg cgaccggcgc
     9001 ggtcagcgtc ttcctgccga cgccggtgtc ccggatggag gcggtggcgg tccaccagat
     9061 cgcgtgcacc gccgcccacg ccgacatccc cggcggccgc cccgccactc aggtcgacgt
     9121 ccggatgtac gagccgaaga gccagggcac cccctggacg gtgcgctgtt ccagcaacgg
     9181 gatcgccctg ccgaccgccg gcccggacac ctggcagaac cccgccccgc gcgcctcccc
     9241 gcgacccgcc ccggacacct cctgagcccc cgcctcccca ccctcgaagt actccctgac
     9301 caggcggctt tgtcagtggt cggcactaaa atcggaggca gtaaggaagc agtccaggac
     9361 tgcttctccg ctgtcccagg aggttgccga tggccgtagc cacgctgtcc acgaaccccg
     9421 ccgtggcgaa gaggaccacg tacggaaagg cggccgcgcg tcgggtggtc cgccgcacgc
     9481 cgatggtcaa gaagtcgctg cccgcggggc tcccccgtga gtggtacgag gcccacaacc
     9541 gccgcctgaa ggccatgcgc ctggcgatag ccctgctcga cggtggcgtc tacaccccgg
     9601 agcgggcccg caaccgcacc atccgcacga ccgcggcccg catcggagtg cacccgccct
     9661 ccaacacgac ctgccgcctg gtccgctccc tgatcattga gaacgcccgc tgaaccggca
     9721 ggcgccgcgc cgccgcctgc gcgcgaacac gagcgacgac tccaaccgac cctgaccaca
     9781 gccggctgac gcactccgca ctccagacct gacccggccc ctcccggcct gcccgggagg
     9841 ggccgatctg ccccgcggct acggccgggg tgcccgccga tgcacaagcc gtacgcgacg
     9901 ctgcgctcgc cgacgtgcaa gccgtacgcg acgctgcgcc cggcggggaa accctgcggc
     9961 aggccctgcg gcaggctgaa aacggctcac tgtgcgacct tcacgccact ccggccgccg
    10021 ccgtcactgt ctccttcgcc gtctccttcg ccgtttccat ctccgtcgct gtctccgtcg
    10081 cctgttgtgc gacccgggcc gccgaagtcc ccagcccggt gggcctgccg ctccacgtac
    10141 cgagcggggc ctcgtttccg gcccccgccc ccgccggcat atccgcaacc cccttgtggc
    10201 gccgcagatc ctcctcccgg taccgccggc actcctggtg ccaggtgagg attccggaca
    10261 tccagttctc cagctccttc acatatccgt ccagcagcgc ccgtgcttcc tccggcagct
    10321 cgaagtcgtc gtacagcacc ggcagttcat tcgccgccac atgctggaac tcccgcatac
    10381 gcgacgtcat gaggtcatgg acgatcgcga gggccgtcgg atagtcgcag tcgaagaagt
    10441 tctgcaccac cagaaccccg ttgtgcacct ctccctcgta ctcgatctcc ttctggtacg
    10501 agaacacgtc gttcagcagc gtcgcgtagt cggcggcggc gttctccagg gaacgcatcg
    10561 gaccgctccg gtagatctcc tgcggaacgc gccgcccgtg cccgatacgg ctcaaactca
    10621 tcgtcatgtc ggagccgaac gtcgcccgcc gcatctcgat gtagtccacc ggatcgggaa
    10681 tgtggtgcag cgcctggttc tccagttccc agatccaccc ggccgtcatc acctcgacgg
    10741 agtcccggaa cgtcttccgc gccgcggcgt ccatggattc cgtcgtacgg cgccacagat
    10801 ccgccagccc gcgttccatc gcgttcgcgg gctccggcat cgcctcgccg tcctccaccg
    10861 gcatgaacgc cgaaagccgc acattgcacg ccttcgcccc ggtcagatcc cgcaccgccc
    10921 cgaacaccgc ggggtagtaa tcgtccccgt acgtccccca cgtcagccac tgcgacccca
    10981 ggtccagttc ctccggcgtc gcctcggggt ccagcccggc agcacacagc gggaagtcgt
    11041 agtcggtcac ctttccggcg tcccagacat ccgacagcgg tacccctgcc tgcggccgga
    11101 acatccccat ctgccgcgcc cattccacgg cgttcacccg ggctccgtcc aggtgcggac
    11161 tgagcgtcgt cgtgaacggc atgtagaagt ccggcagttg cgaagggccc accttccgga
    11221 acggcacatg cgtgaaattc cgtacccgct tcgcccccgt gaccgccagg gcgcgccgga
    11281 catccatccc cgaagtcccg agccccccga aggcgaacgg cgaccagccc cctgccgact
    11341 ccgccgcctt tccgcccccg ttcatgtacc ggctcgacct catatgccat tcatgcccgc
    11401 ccgactgcca gtcctggagc cccttggcat aagccagtac atccgcgcac tcctgcggac
    11461 tcagcccctt ctccgcgaac agcaccggaa gttcggtcag caccgtgttc tcgaactgct
    11521 gaacccgcga ggtgatcagg tcattgacgg cgtccgccga ctcctgggtg gtgcagccga
    11581 ggaagttctc caacaccagc acactattgc tgagctcccc ttcctcctcg gtctcccgct
    11641 ggtacgagaa caggtcgttc cgcaggtgca ccccgtccga gaacgtgtcc ttcagcaccc
    11701 gcaacggccg cgacccggca accgccgccg gcacctcggc ccccgccgcg aactccacca
    11761 gccccgccga ccaaggggcc ccgccgacct tgcgccgcat ctcgatgtat tcgacgggat
    11821 tcggcacccg cccggcgttg atgttcgaca gttcccacaa cgactcgttc agcagatgct
    11881 cggtactctc ccggaaccga gcccgccacc cctccgacat cgaaggcacc gtccgcgccc
    11941 acagatccgc cagccccgcc tcgaccggat tgaccggcgc gggcaccggc gtatccaggt
    12001 ccatcggcat gaacagcggc agccggtcca gatacgcctt tccgcccacc cggtcctgcg
    12061 tccgtttgaa cgcctccagg aaatggtcgt cgaagaagaa cacccacacg taccagtccg
    12121 tcaccagcgc cagcgcatcc gccgagcaat ccggatgcgt atacgcgcac agcaacgcgt
    12181 agtcatgcgc atccagatcc ctctcctccc agatccccga cccctccacc atgcccatcc
    12241 cgcgcgccca ctccttggaa tgccgccgcg ccccctccag atgcgcgttc aatcgcgccg
    12301 gatacggcag atagaatccc ggcaattcaa acggctgccc gctcactgca taccctttcg
    12361 tcgtccatct ctccggtatc accacaagat gtacgccgag caggcaagcc ccggccaact
    12421 ccccgcgttc ccgccgctcg gcggccacag cactacccac ccggcccgcc ttttatccac
    12481 cgtcttgaca gaccgtaagt gcgtatggtc cgggtggcgg ctgtcgtccc atagcttgat
    12541 cgcacgtatt tccgattagc gcgcgaacgg aaagaggcaa agggccgctg ggccgtgctc
    12601 aaccccgcgt actcaacccc gcgtgctcaa ctccgcgggc tcagccccgc cacggtgagc
    12661 cggaacagcc ggtccgccgc ggcggcggga tcgaggtggt gctccgtggc cagggtcagg
    12721 ccgacggcca gcgtgatcag atccgcgacg gtgaactccg gggccaccgc gccgtcctct
    12781 acggcgcggc gcagcagtgg cgctgcggcc tcttccagcg gtgccgagca ggagttctcg
    12841 tacgccgggt cgtcggcccc ggtgctgtcg taggccagtg cgggcgcgag tccgcgggcg
    12901 gtgacgcagt aggcgatgac gtcactcagc cattccagga gcgcggctcg gctgtcgggc
    12961 ctgtcggcca gatcgcgggc gcgtacgcac agcgcctcga tccgctttcc ggcgaccgct
    13021 tccagcagtg cgcggcgggt ggggaagtgc cggcgaaccg tcgccgagcc gacctgcgcc
    13081 gtgcgggcga tctgttccag agaggcgtcg gcgccatggg cggcgacttc ctcctcggcc
    13141 acggcgagga tgcgcgcgta gttgcgcctg gcgtccgcgc gacgggtctc aggacggatc
    13201 tcgggcactg cgtcccctct cacggttgcc aagtggcggg ccccgccata tcgtaccccg
    13261 caaggaaacg gcggggcccg ccacttatag ttcagagcat ccgaggagca ccatgtccac
    13321 agcccctacg tccacacccc cctcgcccgt tctggtcacc ggtgccaccg gccgccaggg
    13381 cggagcgacc gttcgtgccc tgctcgcggc gggcgccccc gtccgcgccc tggtacgcga
    13441 cgcggccacc gaccgggcca aggccgttgc ggcgctcggc gccgaactgg tcaccggcga
    13501 cctgcacgac cgtgagtccg tgatccgcgc cgccgaaggc gtccgagccg tcttctcggt
    13561 gcagatgccc gccttcaccg cggagggccc cgatttcgac ggggaggtgg cccagggcgt
    13621 caacctcgtc gagggcgcga aggccgccgg agtgcggcag ttcgtgtaca gctccgtctc
    13681 cggtgcgggc cggcacaccg aagccccggg ctgggacgag gagcgcttcg gcttcatgaa
    13741 ccccgccatg ggcaccaagg ccgcggtcca ggaccgggtc cgcgaggccg gattccccca
    13801 ctggacgctg ctcaagccgg gcttcttcat ggagaacttc ctgccgtccc tggcctacat
    13861 gttcccccgc ggtatcgagg gcggcctggt gacccttcta aggccggaga cccggctgtc
    13921 cctggccgcg gtggacgaca tcggcgcggc cgccgccgca gccttcgccg ccccggaacg
    13981 gttcgacggg gtcgagctgg agctggcgag cgactacctc tcgatgaccg agatcgccgg
    14041 gaccctctcc cgcgtcttgg ggagggacgt gcccgcccct gacatgaccg aggaggaggc
    14101 cgtcgctgcc ggaatgccgg cgatgggccg ctcacacctg tggctgaatg cgaccggcca
    14161 gccggcccgc ccggagtacg ccaaggacct cggcatcccg ctcaccacct tcgaggaatg
    14221 ggcgcggaag tacatgcggc ccggcgcctg acacggcccg gggctgccgt cgtacggccg
    14281 tggcggcggc agccctcccc gcgggtttca gcccttgcgg ggggagaaac cgccgtcggc
    14341 gtcgccgcgg gccgtacagt ccgtgccctg gtagcggtcg gcgaaggtgc cggtgaggcc
    14401 ggtgaacgcg tcgtagtcat ggtccaaggg cagatctgtg ctcaccctga accgcagctg
    14461 cacatggacg gactcgcggg gtttcagcgt cttcggggcg gggatggtgc cgccggcgtt
    14521 cccgttggcc tggcgcagcg tcttccaggc gcgctgcgag gtgtcccagt actgcagatc
    14581 gccgtacggg ctcaggtcgc gctcgccctc gttgtagacg taactgccca gcttgccgct
    14641 gagttcgaac gacttcagct ccttcgccga ggcgttggtg agcgtggcgg tgtaggtcgt
    14701 ccagtgagtg ccgagagtga tcgacttggg tatgccgaac gagcggccca cgaaggtgtt
    14761 gttgtggggc tgcccgacat cggagcactt cggaaggtcc gcggcagggg ccggggccgc
    14821 ctgcgaggca ggcgcggcgg ccaccgccat gggaagcagg gcagccgtcg cggccgagag
    14881 cgacagggcg cggcgcagtg tcatgaaggt ctctttcccg gttcttcgga cctgtggagc
    14941 ctgtgcttcc ggtgtcgtgg aggcctcagg ccgtgggtcc ttggtcagca ggttcttggc
    15001 gaggcggtcg gggcgtcggg gcgtcggtgt gagggtgtgg gggttacgcg atgacgtccg
    15061 tgacgtccgt ggcgcccgaa cccgccgcgc ccttccggcg gcgcgcgccg atgaccgcac
    15121 ccgcgccgac cgccatcgcg gccccgccgg cgagcgcgat ggccgggagc gcggacgagg
    15181 agccggtcgc ggcgagctgg gcgccgccct gcgcgctgag gccaccggca gaaccggaac
    15241 cacccgtacc gccgccgggc gcggcgctcc ggctgggctc ggcggtcggg gtgggatcgg
    15301 ccgtgccgcc cggcttcccc ggcttgcccg gctcactcgg ctcggcggtc gggggctgcg
    15361 tcggcttcgc gcccgcgggg aggatggtga agtcgtacca ggcttccttg gacgaaccac
    15421 aggaaccgtc gcggttgcgg tagtcgccgg cggcgagcgc gtacccggcg ccgggcttgg
    15481 cgtccttgac cgcgcgggtg cgcagttgga gcgtgacggt gccgcgcgga ccgacggcaa
    15541 agaagccgaa cagttcttcg ggcgccgcgt cgtggaagga cttccactgc cccgtcttgg
    15601 cgtcgcggta ctcggtctcc agctcccagt acggccggtc gacatcttcg gcggaggaca
    15661 cggccaggaa gggctggacc tcctccaggg acgtgccggt ggtgttggtg agcgtcaagg
    15721 agaaggggac ccaggcgccg cccgcggtca gccgcggcgg cagcccgtgg acggccacgt
    15781 tcaactggcc ggactcgaac gcgcaggact gctccgcacc atcgtcatca ccggcgtcct
    15841 tgccgccacc gatggcacca cccgcgcgag tggacccctt ggcctcttcg gcggccccgg
    15901 cggctttcgg cggctgcacc tgggcggcgg ggcgggcggc cccgtcgcga tcctgggctg
    15961 ccgggccatc gggggagccg ggagaggagg cgggcgtgcg gggacccgac tcggacaccg
    16021 gctccgttgc gaacgcggcg gcgggcacgg ccagtacggc ggcgggcgct atcacggcag
    16081 ccgctgcggc agccgtcagg gcacggcgaa ttctcatcca gcagacctct cgaatcccaa
    16141 gcgccgcctg aacgacgcag gttgacgttc gccatggtca ggctgtgcgt gacgcatggt
    16201 gcacgcgagt gcgcttgcag acatgcgtac acctgtgccc cgcacaagac cactcgccca
    16261 gcaaaaaagt tgctcaatca agccactgaa gtgacacatg gggcgagagg gaccttgccc
    16321 accacaagaa ggcaaggccg gacgggttct ttccgctgac ggttctcaca cgccagtggg
    16381 gcggccactc cgtccggagt ggccgcccca ctggcgtact gacggcaggt caggctctga
    16441 gccgtccggt gcgcacacgg tgcacacggg gaggaaagcg cccgccttcg ccttttagat
    16501 gtcgaagtac agctcgaact cgtgcgggtg cgggcggagc tggatcgggg cgatttcgtt
    16561 ggtgcgcttg tagtcgatcc aggtttcgat gaggtcggag gtgaagacgc cgccctgctg
    16621 gagatactcg ttgtcggctt ccagggcgtc gaggacggcc gggaggctgg tggggacctg
    16681 ggggacgccc gcgtgctcct cgggggcgag ctcgtagagg tccttgtcga tcggctcggc
    16741 cggctcgatc ttgttcttga cgccgtccag gcccgcgagg aggagggcgg agaaggcgag
    16801 gtaggggttc gaggacgggt ccggggcgcg gaactcgacg cgcttggcct tcgggttgga
    16861 gccggtgatc gggatgcgca tcgcggcgga gcggttgcgc tgcgagtaca ccaggttgac
    16921 cggggcctcg aagccgggga ccaggcggtg gtaggagttc accgtcgggt tggtgaaggc
    16981 gaggagggag ggggcgtgct tgaggatgcc gccgatgtag tagcgggcgg tgtccgagag
    17041 gcccgcgtag ccctgctcgt cgtagaagag gggctcgccg ccggtccaca gggactggtg
    17101 gacgtgcatg ccggagccgt tgtcgccgaa gatcggcttg ggcatgaagg tggcggtctt
    17161 gccgttgcgc caggcgacgt tcttcacgat gtacttgaag agcatcaggt cgtcggcggc
    17221 ggcgaggagc gtgttgaact tgtagttgat ctccgcctgg ccggccgtgc cgacctcgtg
    17281 gtgctggcgc tcgaccttca ggccggccgc gtcgagctcc agggagatct cggcacgcag
    17341 gtcggcgaag tggtcgaccg ggggagccgg gaagtagccg cccttgtagc ggaccttgta
    17401 accacggttg ttgatctcgg agccggtgtt ccaggcgccg gcctcggagt cgatgtggta
    17461 gaaggactgg ttcgccgacg tctcgaagcg gacgttgtcg aagacgtaga actcggcctc
    17521 cgggccgaag aacgcggtgt cggcgatgcc ggtggaggcg aggtacgcct cggccttctt
    17581 cgccacgttg cgcgggtcac ggctgtactg ctcgccggtg atcgggtcgt ggatgaagaa
    17641 gttgacgttc agcgtcttgt cgcggcggaa cgggtccacg cgggcggtgg agaggtcggc
    17701 gcgcagggcc atgtcggact cgtggatggc ctggaagccg cggatcgagg agccgtcgaa
    17761 ggcgagctcc tcggtcgggt cgaacgcctc cgccggaacc gtgaagtgct gcatcacacc
    17821 gggcaggtcg cagaatcgga cgtcgacgaa cttgacgtcc tcgtccgcga tgaacttcgt
    17881 ggcctcatcg gcgttctgga acatccaact cctcctagcc cggtcaccgg cggtcggcgg
    17941 acgcgggatt gctactcgga gcgcgtcatg tgcggtggcg cgcttgcccg accataggca
    18001 ggcgggattt cccaagcatg acccatttgt ttcgccgagg ttaaccgccg cgcggccctt
    18061 ttcgcggggt gatgtacggg ggaatgggcg aacggaattg atcattccga ggtgggggcg
    18121 ggcggcgtgc gcagtgccgc ggggctgttc ccgtacggcc ccggcgggtg acgggcccgt
    18181 cgcgcggcgg ttccggcgcg gcctccgggg ccctcggtgc tgccccgcga agggggaaac
    18241 gtatgcggtc gcagtaccgt ggacgggtgg acaacaggca agcaatcgga tcgtggatct
    18301 ccgggccccg cgcggcagcc gaggacatgg gtgtcgagtt cggctaccgc gggcagcagc
    18361 tcgggctgcc cgcggagggg ccgggctcga tcgcgcgtcc cggccggcgc ttcgccgccc
    18421 tcttcgtcga ctgggcgctg tgcacgctcg tcgcgtacgg gctgctgagc cacggccggg
    18481 ccgactcgac gagcaactgg gcgctggccg tcttcgtggt gctcagcgtg ctgacggtcg
    18541 gcacggtggg cttcacgccg ggcaagcggc tgctgggcct gcgggtcgtc gccgagggcg
    18601 gcgggcggct gcccctgctg cgcgtggtcc tgcggacggt cctgctggcc gtggtcatcc
    18661 cggcggtgat ctgggaccgc gacggccgcg gcctccacga ccgcctcgcc cgcgccgtgc
    18721 aggtccggat ctgatccgta gggcgatgca ggctccggac gctccgtaca ccccggacgc
    18781 tccgtacggg ttgtaacgga cgtaggcggc gcattccgga accccggcct caggagcctc
    18841 agcctccgga gccccgcctc cagagcctcc ggaaaccctg tctccgaacc ctccgtaaac
    18901 ccccgagggg cccgggacca catggtcccg ggcccctcgg ccgttccggt gatgggcgct
    18961 gtgccgcggg tgcggctcag cgcatcttgc cgccgccgcc cttcggcatg cgcatgccct
    19021 tgggcatggg tcccttcggc accggcatgt tgctcatgag gtcgccgagc gcgcgcaggc
    19081 ggtcgttgac ggccgtgacc tgggcgccgg gcagggtgcg cggcagcttc aggagggtcg
    19141 tacggatctt cttgagcggg acctggccct cgccttcccc gaccaccaga tcgtggacgg
    19201 gcgcgtcggc gacgatgcgg gccatccgct tcttctcggc ggccagcagg ccgcgtacgc
    19261 ggttggggtt gccctcgccc acgaggacga tgcccgcctt gccgacggcg cggtgcacga
    19321 cgtcctgctg gcggttcatc gccacggccg gggtgatcgt ccagccgcgg cccacgttgt
    19381 ccagtacggc cgccgccgcg ccgggctggc cctccatctg tccgaaggcg gccttctcgg
    19441 cacggcggcc gaagatgatc gccatcgcga ggaaggccag cacgaagccc aggatgcccg
    19501 cgtagacggg gtggccgatc aggaagccga gggcgaggag aacgccgaat acgacgatgc
    19561 ccacgccggc gacgacaaga ccgaccttgg ggtcgacccg acgggtcatc ttgtaggtct
    19621 gggcgatctg cttcagtcgc ccggggttcg cagcgccctc agcgctgtct gcttttgcct
    19681 tcctcgccat ggggcgcagt ttacgtggcg ttcgggccct cggtcgccgc ggcctccagt
    19741 acgtgctggg cctcgtgccg gtccctggcg cggcggcggt cctccagcac ggatgtccac
    19801 gcgttccggc gggcggtgcg ctggccaccg cgcatcagta cggactccac tgcgcgcagg
    19861 gcatcggtga ccgacgggat ggggagagcg gcggtggcgc gagcgggcgc ggcctgcatg
    19921 gcgggttccc cttctggagg aatttctgag ggaatggtgg atgcggtgcg tgaagccatc
    19981 gttacagatc ggtgttacca actgatgacc cgccggtcaa acaccgatga aacattgacg
    20041 cggcccgcac cgccccctgc ctgggggagt gcgggccgcg tcgtcgcagc gtgtgccggg
    20101 actcacattc cggcccaggg gtcagtggcg ccccatacgg gccggacgat ggtggccggt
    20161 accggatcgt ggcgagtacg ggtcagacgg cctgcgccga cccttcgacc tgacggcgct
    20221 cgatcgcctg ctggtacagg cggccggcgc ggtaggagga gcggaccagc gggccggaca
    20281 tgacaccggc gtagccgatc tcctcggcct cctccttcag ctccacgaac tcggcgggct
    20341 tgacccagcg ctcgatgggg tggtggcgca ccgacgggcg caggtactgc gtgatcgtga
    20401 tcagttcgca gcccgcgtcg tgcaggtcct ggagcgcctg gctgatctcc tcgcgctcct
    20461 cgcccatgcc caggatgagg ttggacttgg tgaccagtcc ggcctcgcgg gccttggtga
    20521 tgacctcaag ggaccgctcg tagcggaagc cgggacggat gcgcttgaag atccgcggca
    20581 ccgtctcgac gttgtgcgcg agcacctcgg gccgcgagga gaagacctcg gcgagctgct
    20641 cggggaccgc gttgaagtcg gggatgagca gttcgacgcc ggtgtcgggc atcgcggcgt
    20701 ggatctggcg gacggtttcc gcgtacagcc aggcgccgcc gtcgtccagg tcgtcgcgcg
    20761 cgacgccggt gatcgtggcg tacttcagct ccatggtctg gacggattcg gccacccggc
    20821 gcggctcgtc gcggtccagc tcctgcggct tgcccgtgtc gatctggcag aagtcgcagc
    20881 ggcgggtgca ctggtcaccg ccgatgagga aggtcgcctc gcggtcctcc cagcattcgt
    20941 agatgttggg acagcctgcc tcctggcaga ccgtgtgcag gccctccttc ttgaccaggc
    21001 cctgcaggtg gttgtactcg gggcccatct tcgcccgggt cttgatccac tcgggcttgc
    21061 gctcgatggg ggtctggctg ttccggacct ccaggcgcag catcttgcgt ccgtcgggtg
    21121 cgacagcgga cacgtccggc tccctacgac ttcgtttctt cggcgtacac cagggtacgc
    21181 ccgttaattc gcacgtcttt acgtgcaggc caaccccgta tggcagggcc gcattccgcg
    21241 cggtcggttt cgggggattg gtgacctgat gggcgaccgg tccgggaacg gaccggtccg
    21301 cccggtgacc ggctcagacc gcccggggga gcagcacggc gttctccagc acgtcgcgca
    21361 ggtgcttctc gacgacgggc aggacgtcgg cgatggtggt ctcccggccg agttcattgg
    21421 cgagggaggt caccccggcg tcccggatgc cgcaggggac gatcttgtcg aacgaggtgt
    21481 tgtccgggtt cacgttgatc gcgaagccgt gcattgtgac gcccttggcg acgcggatgc
    21541 cgatcgcggc cagcttgcgg tcctcgcggc gctggccggc gttggacggg gcgtactccg
    21601 ggccgttcag ccgggggtcg aactcctcgt cggccgtacg ggggtcgaag tcgagggaga
    21661 ggccgcccag ggccgggcgg tcggcgaccg ggtcgcccag cacccacacg ccgctgcggc
    21721 cctcgacccg gctggtctcc acgccgaagt cggtgcaggt gcggatgatg gcctcttcga
    21781 gacgccgtac gtgggcgacg acgtcgaccg ggcgcggaag cttctggatc gggtagccga
    21841 ccagctggcc gggaccgtgc caggtgatct tgccgccgcg gtcgacgtcg atcaccgggg
    21901 tgccgtccag ggggcgttcg ctgtcgtccg tgcgccggcc cgcggtgtag acgggcgggt
    21961 gctccagcag caggcaggtg tccgggacct cgtcggcgaa ccgggcggcg tgcaccctgc
    22021 gctgctcctg ccaggccgtc tcgtaatcca cggcgtcggc gccgaagccc agctggacaa
    22081 agcgcagccc ctcgggtgtg ggggtgtccc cccgagagat cgcagtcacg gcagctcctc
    22141 ttcgaacttt gttgcgtcct ttgcgcccac gccaactgta cggcgggggc ggacggctcc
    22201 cgcaggcgcc tggggcgggg gcctggtgcg cgggcgcgcg gaagtgcccc gcgcgccccg
    22261 gtggctctcc cggggccacc gttacgggac gg
//
