LOCUS       NZ_LWKZ01000001        21570 bp    DNA     linear   CON 28-MAR-2024
DEFINITION  Streptomyces sp. CB02923 scaffold1, whole genome shotgun sequence.
ACCESSION   NZ_LWKZ01000001
VERSION     NZ_LWKZ01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CB02923
  ORGANISM  Streptomyces sp. CB02923
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 1452656)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1452656)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra,H. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-APR-2016) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2016
            Assembly Method                   :: CLC NGS Cell v. 8.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905005.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:56:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,128
            CDSs (total)                      :: 8,049
            Genes (coding)                    :: 7,904
            CDSs (with protein)               :: 7,904
            Genes (RNA)                       :: 79
            rRNAs                             :: 2, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 145
            CDSs (without protein)            :: 145
            Pseudo Genes (ambiguous residues) :: 0 of 145
            Pseudo Genes (frameshifted)       :: 32 of 145
            Pseudo Genes (incomplete)         :: 128 of 145
            Pseudo Genes (internal stop)      :: 11 of 145
            Pseudo Genes (multiple problems)  :: 22 of 145
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:21:38
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 541230
            Orig. end                         :: 562800
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LWKZ01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21570
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="triceptide"
                     /region_number="4"
                     /rules="((cds(PF04055 and (TIGR04085 or SPASM)) and
                     triceptide_precursor) or triceptide_rSAM)"
                     /tool="antismash"
     cand_cluster    1..21570
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /kind="single"
                     /product="triceptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21570
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11570](-)"
                     /cutoff="5000"
                     /detection_rule="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /neighbourhood="10000"
                     /product="triceptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11570)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /neighbourhood="10000"
                     /product="triceptide"
                     /protocluster_number="1"
     gene            730..1470
                     /locus_tag="A6A06_RS02185"
                     /old_locus_tag="A6A06_02160"
     CDS             730..1470
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003987269.1"
                     /locus_tag="A6A06_RS02185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_02160"
                     /product="response regulator transcription factor"
                     /protein_id="WP_073758208.1"
                     /transl_table=11
                     /translation="MDQTQTTQGGTAAAMPGAQRRILVVEDDPTIVDAIAARLRAEGFQ
                     VQTATDGPSAVDTAEAWQPDLLVLDVMLPGFDGLEVCRRVQARRPVPVMMLTARDDETD
                     MLVGLGVGADDYMTKPFSMRELAARVHVLLRRVERAALAAHTPRSGILRLGELEIDHAQ
                     RRVRVRGTDVHLTPTEFDLLVCLANTPRAVLSREQLLAEVWDWADASGTRTVDSHIKAL
                     RRKIGAERIRTVHGVGYALETPPV"
     gene            1467..2684
                     /locus_tag="A6A06_RS02190"
                     /old_locus_tag="A6A06_02165"
     CDS             1467..2684
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003987270.1"
                     /locus_tag="A6A06_RS02190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_02165"
                     /product="ATP-binding protein"
                     /protein_id="WP_242440529.1"
                     /transl_table=11
                     /translation="MTAPTRRRPAAEKERAGHRARKRARERPWDGLDSLRDRVWIPLWR
                     RIWEGLRPLDPYRSVKAALGALVIVSVILTTLLVFVAVHSETELRVITVFSIIASLLVT
                     QFVAQGLTAPLDDMTDVTRAMADGDYTRRVRGGRRDEFGDLADAFNRMAADLEAVDTHR
                     KELVANVSHELRTPIAALRAVLENVVDGVCEPDPETMRTALKQTERLGRLVEHLLDLSR
                     LDNGVVPLHSRRFEVWPYLSGVLKEANMSRGASTLSGLAGSGTHTRTDVHLHLDVSPPE
                     LTAYADAERLHQVVANLIDNAIKHSPRHGRVTVLARHGETPGGLELEVQDEGPGIPEAE
                     RHHVFERFNRGDPAAPGPGSDGGTGLGLAIARWAVDLHGGRIRVAESPRGCRIRVTLPG
                     SDAIRG"
     gene            2922..6749
                     /locus_tag="A6A06_RS02195"
                     /old_locus_tag="A6A06_02170"
     CDS             2922..6749
                     /EC_number="4.1.1.71"
                     /GO_function="GO:0004591 - oxoglutarate dehydrogenase
                     (succinyl-transferring) activity [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0006099 - tricarboxylic acid cycle
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006127532.1"
                     /locus_tag="A6A06_RS02195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_02170"
                     /product="multifunctional oxoglutarate
                     decarboxylase/oxoglutarate dehydrogenase thiamine
                     pyrophosphate-binding subunit/dihydrolipoyllysine-residue
                     succinyltransferase subunit"
                     /protein_id="WP_073758210.1"
                     /transl_table=11
                     /translation="MSPQSPNSSSTSTDQEGQGKNPAAAFGPNEWLVDEIYQQYLQDPN
                     SVDRAWWDFFADYKPGAGATTPAPASEGSPATPASGTTQAAAPAAPSAPAAPAAPQPAP
                     QAAAPAAAQPAAPAKPAASAPAPAKAAPAKTAPAKPAAKKDDVKADEAPAGPELVTLRG
                     PSAAVAKNMNASLELPTATSVRAVPVKLLFDNRIVINNHLKRARGGKVSFTHLIGYAMV
                     QALKAMPSMNHSFQEKDGKPTLVKPEHINLGLAIDLVKPNGDRQLVVAAIKKAETLSFF
                     EFWQAYEDIVRRARNNKLTMDDFTGVTASLTNPGGIGTVHSVPRLMPGQGLIVGVGAMD
                     YPAEFQGTSQDTLNKLGIAKVMTLTSTYDHRVIQGAASGEFLRVMNQLLLGENGFFDDI
                     FKSLRIPYEPVRWLRDIDVSHDDDVTKAARVFDLIHAYRVRGHVMADTDPLEYEQRKHP
                     DLDIIEHGLTLWDLEREFAVGGFAGKTMMKLRDILGVLRDSYCRTTGIEFMHIQDPKQR
                     KWIQDRVERGHSKPEREEQLRILRRLNSAEAFETFLQTKYVGQKRFSLEGGESVIPLLD
                     AVIDSAAESRLDEVVIGMAHRGRLNVLANIVGKSYAQIFREFEGNLDPKSMHGSGDVKY
                     HLGAEGTFTGLDGEQITVSLAANPSHLEAVDPIVEGISRAKQDIIGKGGTDFTVLPVQL
                     HGDAAFAGQGVVAETLNMSQLRGYRTGGTVHIVINNQVGFTAAPESARSSMYATDVARM
                     IEAPIFHVNGDDPEAVVRVARLAFEFRQAFNKDVVIDLICYRRRGHNETDNPGFTQPLM
                     YDLIDKKRSVRKLYTESLIGRGDITLEEAEQALQDFQGQLEKVFTEVREATTAPAAPEV
                     PEPQAEFPVTVETAISQEVVKRIAESQVNIPERVTVHPRLLPQLQRRAAQVEDDTIDWG
                     TGETLAFGSLLMEGTPVRLSGQDSRRGTFGQRHAVLVDRETGEDYTPLLYLSEDQARFN
                     VYDSLLSEYAAMGFEYGYSLARPEALVMWEAQFGDFVNGAQTVVDEFISSAEQKWGQTS
                     GVTLLLPHGYEGQGPDHSSARIERFLQLCAQNNMTVAMPTLPSNYFHLLRWQVHNPHHK
                     PLVVFTPKSMLRLKAAASKTAEFTTGGFRPVISDDAAKAEDVTKVVFCSGKVYYDLEAE
                     RVKRGAFDTALVRIERLYPLPGKELQAEIAKYPNAGKYLWMQEEPANQGAWPFLGLNLI
                     DHLDLSVGADVPHGERLRRISRPHSSSPAVGSAKRHQAEQAALIAETFDA"
     gene            complement(6837..9842)
                     /gene="fxsT"
                     /locus_tag="A6A06_RS02200"
                     /old_locus_tag="A6A06_02175"
     CDS             complement(6837..9842)
                     /codon_start=1
                     /gene="fxsT"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003986809.1"
                     /locus_tag="A6A06_RS02200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_02175"
                     /product="FxSxx-COOH system tetratricopeptide repeat
                     protein"
                     /protein_id="WP_073758212.1"
                     /transl_table=11
                     /translation="MADQSGTTGSAEHITISYAGFNRPWAAWISHQLEQLGHGTTMLRW
                     DPPADSPLTEELAGLLAAEGRLLMVLDDWYFKLGPKTHDEWTTALQEVVPDHADRFAAV
                     SVATQRLPATASVLRPADLRDLDAVEANRRVLNRLGVPTAGRRPADPAANAPRFPNDPP
                     EIWNIPRRNNRFTGRDTALEELHGKLAGPVPGLGQPLETRIALYGISGVGKSQIAAEYA
                     HRFGNDYDVVWWISATNRGAAREQLAELATRLGLPVGQELGDRIRAVHEALRVGRPYRR
                     WLLIFDSADDMEQIEDLVPDGRGHVLITTLTRDWSGSGSAQEIEVLPFTRIESVAYARR
                     RAPRLTNMEADLLADAVQDLPLLLAQTAAWLDANPMAPKEYIELIRRGEPSLVGIRIST
                     DYPMAFQTSWAITLNTLRERSPAAVELLKLFAFFAPDAIPVPMLARARRGDLPEYLADL
                     AAEPIAWNTALRRLTESTAVRLDYQVAQTTSDPAVETAQMHRLYHRFLRSDMAEDERDG
                     MSATACRVLATADPQSPSDTRTWEQYAALIPHLEPAGVLDSPETSVQELLLNCVEYLRV
                     RGEYRIGLRLCEQFLSRWRTRIAPTQRTMLVVTHQHANMLRRLGRYREAEAVGSAIVEE
                     LTAEREPGDGALLRAQDGLAGTLMALGSYGQALEIFDSVVRGRTELLGAEAPLTLSSRS
                     NLASALSAVGRYQDALELFGEVLLVWERELRARHHLTLGAAYSYARMLRLLGRYTDALS
                     RQELNVRLYHQVMGKHTPLTLRAEHNLALCLRRSGAVTQADGLMGDVVDRSRRVHGPRH
                     PETLMMQTNYATFLREHGDLGKARELGEEAAARYRTLVGEAHPFTVGALGNTGLVCWEF
                     GERDNALAIAEQALRGMTRAVGPDHPWTLGCALNAAGARNRVDDEESAAQLSRDTLERA
                     KRVLGDTHPLTLSVRTALADDLRALRRGQEASKLEQQAVQQLTETLGAEHPHTLSARRR
                     RRPYWDFEPQPV"
     gene            complement(10001..11155)
                     /locus_tag="A6A06_RS02205"
                     /old_locus_tag="A6A06_02180"
     CDS             complement(10001..11155)
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     triceptide: triceptide_rSAM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SAM_SPASM_FxsB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006603148.1"
                     /locus_tag="A6A06_RS02205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_02180"
                     /product="FxsB family cyclophane-forming radical SAM/SPASM
                     peptide maturase"
                     /protein_id="WP_242440530.1"
                     /sec_met_domain="PTHR43273 (E-value: 2.7e-79, bitscore:
                     263.1, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="SAM_SPASM_FxsB (E-value: 3.2e-125,
                     bitscore: 414.0, seeds: 10, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.6e-13, bitscore: 46.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="triceptide_rSAM (E-value: 1.0, bitscore:
                     1.0, seeds: 0, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVCQSLHRTAVPFRQFVLKTHSRCNLACTYCYIYAGPDRSWRDRP
                     THAPPGTVRQTARRIAEHVRAHGLDAIRIDLHGGEPLLTGPGPLLAQAAALRAALPAGC
                     RAHLGVQTNGTLLTPPVLDTLAGAGFRIGLSLDGGTPGLNRRRIDHAGRPSWPAASRAA
                     RLLAGRPGVFAGILCTIDLTSDPARVYRSLRALGPPMLDFLLPHANWTIRPPLPPGPAG
                     RTPYGDWLCTVFDLWWAERDPAPRVRLFTEIIGLLLGRPSTSEAVGLSPVVAVVVDTDG
                     AIEQVDSLKSAYEGAAATGLDVFRNSFDEALGHPGMTARRLGADGLCDRCRACALMTVC
                     GGGNYAHRYRAGGSGFRNPSVYCADLERVIRHIAARLDAEVRVD"
     gene            complement(11325..11570)
                     /locus_tag="A6A06_RS02210"
                     /old_locus_tag="A6A06_02185"
     CDS             complement(11325..11570)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     triceptide: triceptide_precursor"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003986810.1"
                     /locus_tag="A6A06_RS02210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_02185"
                     /product="YxD-tail cyclophane-containing RiPP peptide"
                     /protein_id="WP_073758214.1"
                     /sec_met_domain="triceptide_precursor (E-value: 1.0,
                     bitscore: 10.0, seeds: 0, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATVPVIGTAPAAPAEPSGPPAEPLPDFGGVDVAALAARTGHPVL
                     GEVTALLLRNWASAAEAVAYYDDGPGDPDPNPDPDR"
     gene            complement(11652..14963)
                     /locus_tag="A6A06_RS02215"
                     /old_locus_tag="A6A06_02190"
     CDS             complement(11652..14963)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006603150.1"
                     /locus_tag="A6A06_RS02215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_02190"
                     /product="SAV_2336 N-terminal domain-related protein"
                     /protein_id="WP_079193740.1"
                     /transl_table=11
                     /translation="MPAGGPGFGPLGEIVARLRAAGLPADARAMADALWLARWITPAPP
                     RDDGEPAEGAVPSATQRPKPATFSVDPRSREPSQDAPSRTEPAARDRPRRPEVELLPAP
                     DDRPLGPGQGRLGEVGIPVASAFPGLLPLQRALRPVQRYHPPVAPARQELDEDATADLS
                     AHAELIIPVLRGIRRRAASLRLLMDGSSSMAVWEQMLHDLRQVCERVGAFRDVTVHYLH
                     PHGDEVGVAAGPDRSAPLRPADQLHDPTGHHLTLVVSDCAGPLWRDGRIQRLLYRWAAD
                     APLAVVQPLPQRMWARSLLPAVAGTLVRRQGPYRALDFRPARRRRAPSAAGRPQDGIRE
                     RAVPVLSAAPAALGSWARLAAAESGLSLRGAAAVVRCDHGLGTDLTRRPERPEPHRLVA
                     EFEQSASPDARHLAVHLSAVPLALPVIQLVQRAMLPQTGPAELAEVLLSGLIEQLPDPA
                     AAPGRESVAGGPWYEFVPGVRDELLSRLSAGEAALVLKHCSLYIERTFGRSARNFPAVA
                     VAMLSGSGREPTTGQRAVPEPFARISERVLRRFEPALRTPVQLPYAPDGPAAEGAALLE
                     RYEQDATVRDLIEAVRLLRAAARQLPAAGTDLARALLHAWAEWRQPDALEEAERAVRAA
                     AEAVGGDPAQTPDGDGEARIRALIVLARVRYAGAQERGAAGYPDGERGALEDAARHLDT
                     ACGLMSLLDPRVLESMVLRTEVLRRLAALPPAARTGTGTGRPGDPLGDAEHALTTLLEQ
                     WPSGEQVPGEIYAARGGVLLDQARRAAGEDTGTETHTGALALRATADLDTATVLLRRRG
                     GSADRKICETLLELAQARSLLGPGTGPDTVLPVLQRARALARELRDPALEAESLSRTAT
                     AYRTVHTRTGDPGALDSAIDALAAALRLTTPDSPEHSSLLAERGAALLLRARLEPPGEQ
                     GKRLANEAVHVLREALGRVAPHDPELGSHRLLFGRALRLRHDRQPSLADLHEADWVLEL
                     AARSSHDPAVGAEAWLEVGDVQLALDRRFGSRERHDRAAACYRRAAADADRAGSPLLAA
                     RAHHRRAGVLEDTAGPQAALVAYRESWEQWQRASEESGPEARRTRERMRALDPSV"
     gene            complement(14970..16028)
                     /locus_tag="A6A06_RS02220"
                     /old_locus_tag="A6A06_02195"
     CDS             complement(14970..16028)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006603151.1"
                     /locus_tag="A6A06_RS02220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_02195"
                     /product="MoxR family ATPase"
                     /protein_id="WP_073758216.1"
                     /transl_table=11
                     /translation="MSDWLIYRGAGAPHDGIEQLPPPPPWRDFDGGPPVAPPAALDHAS
                     ERRLGVQRREASYHRPGETERELVNAALYLRRPLLVTGAPGSGKSTLAHSVAYELGLGR
                     VLNWSIVSRSSLRDGLYEYDAIGRLQDLQIARAARPQAGPVPGGGSPEPQDEPGGGIGR
                     YIRLGPLGTALLPAAKPRVLLVDELDKSDIDLPNDLLNVLEEGEFRIPELERLAGSAPE
                     VPVLGDDGGHVTVRDGRVRCRAFPFIVLTSNGERDFPAPLLRRCIHLNIPTPDKERLAD
                     MVRAHFGESAAADYESLIDRFLDREPGDVRAVDQLLNAIHLTQKAGWADEDEEETRRRL
                     TAELLRPLDRTR"
     misc_feature    complement(15969..15971)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(16216..18417)
                     /locus_tag="A6A06_RS02225"
                     /old_locus_tag="A6A06_02200"
     CDS             complement(16216..18417)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003986913.1"
                     /locus_tag="A6A06_RS02225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_02200"
                     /product="trypsin-like peptidase domain-containing protein"
                     /protein_id="WP_073758218.1"
                     /transl_table=11
                     /translation="MAAPEGGQGSVRGERADRERYARLLGHAGRATVAIRPAPGVRPAP
                     LWGSGVFVAPGWVLTCAHVLASGDGRRRPTGPAGEVGVAFGGRVVAARLEYDLSRPAPA
                     GEAAPPYGAAVDERPGSATALGDAGHTSGPAAPTPRVDLALLRLLDPETPHPCAWLSDQ
                     PAALLEDAFIFRGHDQDRPGAAEAAYGEGGPDTAADVHPFIAVRFGARDARGLQFGSDV
                     RVTPGASGGPLLDCDRGEVVGIVKGSHREDRLGLAVPVTELRGLAPHHLVPGATGLGDD
                     PYHALMGLHDRWHWAGQDLGGPGEPTWFDAQHAIMSGRGRLWGVQERLQALDLLASLPA
                     PCDPLVVAAAVAEALGRADPEGRTGRAGPWTLRTWRDGHGALYQGSDPYTELCAFVHYL
                     RIVAQRTADEAREAPGDAGAVMRAAAERLELFVTAKAVVLLPRDRERIGPVRRRPDALL
                     VEFEPLFYDGMGGRQLFNWSVSEGYGQGRWQRVEIQESRDGMSFEQAVDQVLRRLGPRL
                     LRADDAAGGARVRLEVAVPEERWHTPADRWRVPASTRRAARLRPLGPARAVVLRDQGRR
                     QEVDPAWLRRWQGLAAAGRLTGLRVPAGTRASTSGLSRLLEEAGEGAVPALCRSVAGGT
                     GLEAVGWALDTGHPVALWLAEGHDERDCDRVCDEFHREVRQLLGAPKSVAELPELVREL
                     RAKAAEGGVSWARDLVLLYDDPGNPIPQLFSQAAQLSPQ"
     gene            complement(18417..18818)
                     /locus_tag="A6A06_RS02230"
                     /old_locus_tag="A6A06_02205"
     CDS             complement(18417..18818)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003986912.1"
                     /locus_tag="A6A06_RS02230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_02205"
                     /product="CU044_2847 family protein"
                     /protein_id="WP_073758220.1"
                     /transl_table=11
                     /translation="MRDRAHLIELPDGTEVWARVSRLDVAGEPDGEYDDVGAWEALGAR
                     VEGLRELVGGVAASLRAATERVAPDETSVSFGVEVAAKPGRAVALLADGEAKANLSVTL
                     TWRRKEAPGEGRIPDGGRGDGRGPHDSGA"
     misc_feature    18965..18980
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.25"
                     /tool="antismash"
     gene            18970..19149
                     /locus_tag="A6A06_RS02235"
                     /old_locus_tag="A6A06_02210"
     CDS             18970..19149
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889383.1"
                     /locus_tag="A6A06_RS02235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_02210"
                     /product="DUF6104 family protein"
                     /protein_id="WP_030017204.1"
                     /transl_table=11
                     /translation="MYFTDRGIEELESRRGEEEVTLGWVAEQLRTFVDLNPDFEVPVER
                     LATWLARLDDEDDD"
     misc_feature    complement(19254..19269)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.95"
                     /tool="antismash"
     misc_feature    19696..19711
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.44"
                     /tool="antismash"
     misc_feature    complement(19932..19948)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 20.55"
                     /tool="antismash"
     gene            19965..20876
                     /locus_tag="A6A06_RS02240"
                     /old_locus_tag="A6A06_02215"
     CDS             19965..20876
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003986910.1"
                     /locus_tag="A6A06_RS02240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_02215"
                     /product="DUF4097 family beta strand repeat-containing
                     protein"
                     /protein_id="WP_073758222.1"
                     /transl_table=11
                     /translation="MPDRTEWSVSDPRTLEIENSVTALEVRIVGGTVNVVGTADAGPAR
                     VEVGELSGPPLTIRREAGTLTVTYDDLPWKGSLKRISRAAWNRSAVVSVTVPAATRVAI
                     GTVGASAVVSGISGRTELRGVSGDSTLVRLTGPVRAETVSGRVEGQAVTGDLSFQSISG
                     DLTLVDGSGGTVKADSVSGDMVLDLDPAAEGAFVRLATVSGEVAIRLPAPGDTEVEANT
                     TSGMVTNAFEDLRVSGRWGATRITGRLGSGSGTLKVTTVSGALALLRRPPSEERATGPH
                     AEAGAARNGTGETPSPADKKVL"
ORIGIN
        1 ccgtacggcg aggtcgtcct gcggcagcgg ggcgagcact tcgagatcat cgccaacggg
       61 tgctttctga tggacacctc ggacgggcgg tcggagcggc ttctggtgga tgcggcgctt
      121 gcggaactgg cgggtcgggc ggatgacgcg cggccgttgc cccatgtgct gatcggtggg
      181 ctgggggtcg ggttttcgct ggtcagggcg gtggaggggg ctcggtgggg gcggatcacg
      241 gtggtggaga gggagccggc ggtcatcgac tggcaccgtg acgggccgct gtccgccctg
      301 tccggggcgg cgctggccga tgtccgtacc gagatcgtcg ccgccgatct ggtcgggtac
      361 gtgcgggcgg gcgccgggcc gcgcacgttc gacgcgctgt gcctggacat cgacaacggg
      421 ccggagtgga ccgtcacgga ggacaacggc ggcctctact cccccgccgg tctcgcggcc
      481 tgccgggagc ggctgacgcc cggcggtgtg ctcgccgtgt ggtcggcgca gccgtcgtcc
      541 gcgttcgagg acgcgctgcg ttatgccggg ttcaccggtg tacgtaccga agagatcccc
      601 gttgtccgag gcgtcccgga cgtggtgcac ctcgcgcgca agggcgcgta gccgacggtc
      661 acaccctgcc cttacgctgc tgcccagcag tacgcgacca tgcagcacgg ggacacgcag
      721 gggcgggcga tggatcagac gcagaccacc cagggcggca ccgccgcggc catgcccggc
      781 gcccagcgcc ggatcctcgt cgtggaggac gacccgacca tcgtggacgc catcgcggcc
      841 cggctgcgcg ccgagggttt ccaggtgcag accgccaccg acggtccgtc cgcggtggac
      901 accgccgagg cgtggcagcc ggacctgctg gtcctggacg tgatgctgcc gggcttcgac
      961 gggctggagg tgtgccgccg ggtgcaggcg cggcggccgg tgcccgtcat gatgctcacc
     1021 gcgcgtgacg acgagacgga catgctggtc ggcctgggcg tcggcgcgga cgactacatg
     1081 accaaaccgt tctccatgcg ggagctggcg gcccgggtgc atgtgctgct gcggcgcgtg
     1141 gagcgcgcgg cgctggccgc gcacacgccg cgcagcggca tcctgcgcct gggtgagctg
     1201 gagatcgacc acgcgcagcg ccgggtgcgg gtgcgcggca ccgacgtaca cctgacgccg
     1261 acggagttcg acctgctggt gtgcctggcc aacacgccgc gcgcggtgct ctcccgcgag
     1321 cagctgctgg ccgaggtctg ggactgggcg gacgcctccg gcacccgtac ggtcgacagc
     1381 cacatcaagg cgctgcgccg caagatcggc gcggagcgca tccgtacggt ccacggcgtc
     1441 gggtacgcgc tggagacccc gccggtatga cggcacccac ccgccgccgg ccggccgccg
     1501 agaaggagcg ggccggacac cgggcccgca agcgcgcccg ggagcgtccc tgggacgggc
     1561 tggacagcct gcgggaccgg gtctggatcc cgctgtggcg gcgcatctgg gagggtctgc
     1621 gtccgctgga cccgtaccgc tcggtcaagg cggcgctcgg cgcgctggtc atcgtctcgg
     1681 tgatcctcac gacgctgctg gtgttcgtcg ccgtccactc cgagaccgag ctgcgggtca
     1741 tcacggtctt ctcgatcatc gcctcgctgc tggtcaccca gttcgtcgcg cagggcctga
     1801 ccgcgccgct ggacgacatg acggacgtga cgcgggcgat ggcggacggc gactacaccc
     1861 gccgggtgcg cggcgggcgg cgcgacgagt tcggtgacct ggccgacgcc ttcaaccgga
     1921 tggccgccga cctggaggcg gtggacaccc accgcaagga gctggtcgcc aacgtctcgc
     1981 acgagctgcg taccccgata gcggccctgc gcgccgtcct ggagaacgtg gtggacggtg
     2041 tctgcgagcc cgatccggag acgatgcgca cggccctgaa gcagacggag cggctggggc
     2101 ggctggtcga gcacctcctc gacctgtccc ggctggacaa cggcgtggtg ccgctgcact
     2161 cccgccgctt cgaggtgtgg ccgtacctct ccggggtgct caaggaggcc aacatgagcc
     2221 gcggcgcctc cacgctctcg gggctcgccg gttccggcac gcacacccgt acggacgtgc
     2281 atctgcatct ggacgtctcg ccgccggagc tgaccgcgta cgcggacgcc gagcggctcc
     2341 accaggtcgt cgcgaacctg atcgacaacg ccatcaagca cagcccgcgg cacggccggg
     2401 tcacggtgct ggcgcggcac ggcgaaacgc ccgggggcct ggagctggag gtgcaggacg
     2461 aggggccggg catcccggag gccgagcggc accacgtctt cgagcgcttc aatcggggcg
     2521 acccggcggc gccggggccg ggcagcgacg gcggtacggg gctgggtctg gccatcgcgc
     2581 gctgggcggt ggatctgcac ggcgggcgga tccgggtggc ggaatcgcct cgcggctgcc
     2641 gcatccgcgt cactcttccg ggaagcgacg ccatccgagg ttgacgtcgg gtgacgtagg
     2701 gtcggtggcg gaaacacacc gtgccgggcg cggcggcgat gccgcctacc cgcacgcagg
     2761 tgaacctggt gtgtttccca tcccgtcatg ccccgaaacc cgctgccgaa tgtgacgtgc
     2821 acgacgactg acggccccgg actgcaccaa aggtccggag aggcgtagcc tttattcccg
     2881 ctgtccacca ccttaggaag cggaagaggg cggttgccgc cgtgtcgcca cagtccccca
     2941 acagctcgag cacttcgact gaccaagagg ggcagggtaa gaaccctgct gccgcgttcg
     3001 gtccgaatga gtggctcgtc gatgagatct accagcagta cctccaggac ccgaactcgg
     3061 tagaccgagc ctggtgggac ttcttcgccg actacaagcc gggagcgggc gccacgacgc
     3121 cggccccggc gagtgaaggc agccccgcca ctccggcctc cggaacgacc caggccgccg
     3181 ctccggcggc gccgagcgcg cccgcggcac ccgccgcacc acagcccgcg ccgcaggcag
     3241 ccgcgcccgc cgcggcgcag cccgccgctc cggccaagcc ggccgcgagc gccccggctc
     3301 ccgccaaggc cgctccggcg aagaccgcac ccgccaagcc cgctgccaag aaggacgacg
     3361 tgaaggccga cgaggcgccc gcgggcccgg aactggtcac cctgcgtggc ccctccgcgg
     3421 ccgtcgcgaa gaacatgaac gcctctctgg agctgcccac ggccacgtcc gtgcgcgccg
     3481 tcccggtgaa gctgctgttc gacaaccgca tcgtcatcaa caaccacctc aagcgcgccc
     3541 gcggtgggaa ggtctccttc acccacctga tcgggtacgc gatggtgcag gccctcaagg
     3601 ccatgccgtc gatgaaccac tccttccagg agaaggacgg caagccgacg ctggtcaagc
     3661 ccgagcacat caacctcggc ctggccatcg acctggtgaa gcccaacggt gaccgccagc
     3721 tcgtcgtcgc ggcgatcaag aaggcggaga cgctcagctt cttcgagttc tggcaggcgt
     3781 acgaggacat cgtccgccgc gcccgcaaca acaagctgac gatggacgac ttcaccgggg
     3841 tcaccgcgtc gctgacgaac ccgggcggca tcggcaccgt ccactccgtg ccccgtctga
     3901 tgcccggcca gggcctcatc gtcggtgtgg gcgcgatgga ctacccggcg gagttccagg
     3961 gcacctcgca ggacaccctg aacaagctgg gcatcgccaa ggtcatgacg ctgaccagca
     4021 cgtacgacca ccgcgtgatc cagggcgccg cctccggcga gttcctgcgc gtgatgaacc
     4081 agctgctgct cggcgagaac ggcttcttcg acgacatctt caagtcgctg cgcatcccct
     4141 acgagccggt gcgctggctg cgcgacatcg acgtcagcca cgacgacgac gtcaccaagg
     4201 cggcccgggt cttcgacctg atccacgcct accgggtgcg cggccacgtc atggccgaca
     4261 ccgacccgct ggagtacgag cagcgcaagc accccgacct cgacatcatc gagcacgggc
     4321 tgacgctgtg ggacctggag cgcgagttcg ccgtcggcgg cttcgccggc aagaccatga
     4381 tgaagctgcg cgacatcctg ggcgtgctgc gcgactcgta ctgccgcacc accggcatcg
     4441 agttcatgca catccaggac ccgaagcagc gcaagtggat ccaggaccgg gtcgagcgcg
     4501 ggcactccaa gccggagcgc gaggagcagc tgcgcatcct gcgccggctg aactccgccg
     4561 aggcgttcga gacgttcctg cagacgaagt acgtcggcca gaagcggttc tccctggagg
     4621 gcggcgagtc cgtcatcccg ctgctggacg cggtcatcga ctcggccgcc gagtcgcgcc
     4681 tggacgaggt cgtcatcggc atggcccacc gcggccggct gaacgtcctc gccaacatcg
     4741 tcggcaagtc gtacgcgcag atcttccgcg agttcgaggg caacctcgac ccgaagtcga
     4801 tgcacggctc cggcgacgtg aagtaccacc tgggcgccga gggcaccttc accggcctgg
     4861 acggcgagca gatcacggtc tcgctggccg ccaacccctc gcacctcgaa gcggtcgacc
     4921 cgatcgtcga gggcatctcc cgcgccaagc aggacatcat cggcaagggc ggcacggact
     4981 tcaccgtcct gcccgtccag ctgcacggtg acgcggcgtt cgcgggccag ggcgtggtcg
     5041 ccgagacgct gaacatgtcg cagctgcgcg gctaccgcac cggcggcacc gtgcacatcg
     5101 tcatcaacaa ccaggtcggc ttcaccgccg cgccggagtc ggcccgctcc tccatgtacg
     5161 ccacggacgt ggcccgcatg atcgaggcgc cgatcttcca cgtgaacggt gacgacccgg
     5221 aggccgtggt gcgggtcgcg cgcctcgcct tcgagttccg ccaggcgttc aacaaggacg
     5281 tcgtcatcga cctgatctgc taccggcgcc gcggtcacaa cgagaccgac aacccgggct
     5341 tcacgcagcc gctgatgtac gacctgatcg acaagaagcg ctcggtgcgc aagctctaca
     5401 ccgagtcgct gatcggccgt ggcgacatca cgctggagga ggccgagcag gccctccagg
     5461 acttccaggg ccagctggag aaggtcttca cggaggtccg cgaggccacc accgcgccgg
     5521 ccgcccccga ggtgccggag ccgcaggccg agttcccggt cacggtggag accgcgatct
     5581 cccaggaggt cgtcaagcgg atcgccgagt cccaggtcaa catccccgag cgggtcaccg
     5641 tccacccgcg cctgctgccg cagctgcagc gccgcgcggc ccaggtggag gacgacacga
     5701 tcgactgggg tacgggcgag accctcgcct tcggctccct gctgatggag ggcaccccgg
     5761 tccgcctgtc gggccaggac tcccgccgcg gcaccttcgg ccagcgccac gcggtgctgg
     5821 tggaccggga gaccggcgag gactacaccc cgctgctcta cctgtccgag gaccaggcgc
     5881 gcttcaacgt ctacgactcg ctgctgagcg agtacgcggc gatgggcttc gagtacggct
     5941 actcgctcgc ccgccccgag gcgctggtca tgtgggaggc gcagttcggt gacttcgtca
     6001 acggcgcgca gaccgtcgtc gacgagttca tctcctcggc cgagcagaag tggggccaga
     6061 cctccggcgt cacgctgctg ctgccgcacg gctacgaggg ccagggcccg gaccactcct
     6121 cggcccggat cgagcgcttc ctccagctgt gcgcgcagaa caacatgacc gtcgccatgc
     6181 cgacgctccc gtcgaactac ttccacctgc tgcgctggca ggtgcacaac ccgcaccaca
     6241 agccgctggt cgtcttcacc ccgaagtcga tgctgcgtct gaaggccgcg gcgtcgaaga
     6301 cggcggagtt caccacgggc ggcttccggc cggtgatctc ggacgacgcg gcgaaggccg
     6361 aggacgtcac gaaggtcgtc ttctgctccg gcaaggtcta ctacgacctg gaggcggagc
     6421 gggtcaagcg cggtgcgttc gacacggcgc tggtccgtat cgagcggctg tacccgctgc
     6481 ccggcaagga gctccaggcg gagatcgcca agtacccgaa cgcgggcaag tacctgtgga
     6541 tgcaggagga gccggcgaac cagggtgcgt ggccgttcct gggtctgaac ctgatcgacc
     6601 acctggacct gtccgtcggt gccgatgtgc cgcacggcga gcgtctgcgc cgcatctcgc
     6661 ggccgcactc ctcgtcgccg gccgtgggct cggccaagcg ccaccaggcc gagcaggccg
     6721 cgctgatcgc cgagacgttc gacgcgtaaa gccggtacca ccggtgtgaa agcccggggc
     6781 cccgccgcga acgaccgacg ttcgctgcgg ggccccgggc cgttctgtgc gcggggtcag
     6841 accggctggg gctcgaagtc ccagtacggg cggcgccggc ggcgtgcgga gagggtgtgc
     6901 gggtgttcgg cgccgagggt ctcggtgagc tgctgtacgg cctgctgctc cagcttggac
     6961 gcctcctggc cgcgccgcag tgcccgcagg tcgtcggcga gtgccgtccg gacggagagc
     7021 gtcagcgggt gggtgtcgcc gagcacccgc ttggcgcgct ccagcgtgtc ccggctcagc
     7081 tgcgcggcgc tctcctcgtc gtcgacgcgg ttgcgggcgc cggcggcgtt cagggcgcag
     7141 cccagcgtcc aggggtggtc ggggcccacc gcccgggtca tgccgcggag ggcctgttcg
     7201 gcgatggcca gcgcgttgtc ccgctcgccg aactcccagc acaccaggcc ggtgttgccg
     7261 agcgcgccga ccgtgaacgg gtgggcctcg ccgaccaggg tgcggtagcg ggcggcggcc
     7321 tcctcgccca gttccctggc cttgccgagg tcgccgtgct cccgcaggaa cgtggcgtag
     7381 ttggtctgca tcatgagcgt ctccgggtgc cgggggccgt gcacccggcg ggagcggtcc
     7441 acgacgtcgc ccatcagtcc gtcggcctgg gtcacggcgc cggagcggcg caggcacagc
     7501 gcgaggttgt gctcggcgcg cagggtgagc ggcgtgtgct tacccatgac ctggtggtag
     7561 agacgtacgt tcagctcctg gcgggacagt gcgtcggtgt agcggccgag caggcgcagc
     7621 atccgggcgt aggagtaggc ggcgccgagg gtgaggtggt gccgggcgcg cagttcgcgc
     7681 tcccagacga gcagcacctc gccgaagagt tccagggcgt cctggtagcg gcccacggcg
     7741 ctgagcgccg aggcgaggtt gctgcgtgag gagagcgtga gcggggcttc ggcgccgagg
     7801 agttccgtac ggccgcggac gaccgaatcg aagatctcca gcgcctgtcc gtaggagccg
     7861 agcgccatca gggtgccggc gaggccgtcc tgtgcgcgca gcagcgcgcc gtcgcccggc
     7921 tcccgttcgg cggtcagctc ttcgacgatg gcgctgccga cggcttcggc ctcccggtag
     7981 cggcccagcc tgcgcagcat gttggcgtgc tggtgggtga ccacgagcat ggtgcgctgg
     8041 gtgggggcga tgcgggtacg ccagcgggac aggaactgct cgcacagccg caggccgatg
     8101 cggtactcgc cgcggacccg gaggtactcg acgcagttca gcagcagttc ctggacggag
     8161 gtctccgggc tgtccaggac gccggccggc tccaggtgcg ggatgagggc ggcgtactgc
     8221 tcccaggtcc gggtgtcgga cgggctctgc gggtcggcgg tggccagcac ccggcaggcc
     8281 gtggcggaca tgccgtcccg ctcgtcctcg gccatgtcgc tgcgcaggaa ccggtggtag
     8341 agccggtgca tctgcgcggt ctcgacggcg gggtccgagg tggtctgggc gacctggtag
     8401 tccaggcgta cggcggtgga ctcggtcagc cggcgcaggg cggtgttcca ggcgatgggc
     8461 tcggccgcca ggtcggcgag gtattcgggc aggtcgccgc gccgggcgcg ggcgagcatg
     8521 ggcacgggga tcgcgtcggg tgcgaagaac gcgaacagtt tgagcagttc gacggcggcg
     8581 gggctgcgct cgcgcagggt gttcagcgtt atggcccagc tggtctggaa ggccatcggg
     8641 tagtcggtgg agatgcggat gccgaccagg ctcggttcgc cgcggcggat cagctcgatg
     8701 tactccttgg gcgccatcgg gttggcgtcc agccaggccg cggtctgggc gagcagcagc
     8761 ggcaggtcct gcacggcgtc ggcgagcagg tcggcttcca tgttggtcag gcgcggggcg
     8821 cgccgccgcg cgtaggcgac ggactcgata cgggtgaagg gcagcacctc gatctcctgg
     8881 gcgctgccgg atccggacca gtcgcgggtg agggtggtga tcaggacgtg cccgcggccg
     8941 tccggtacca ggtcctcgat ctgctccatg tcgtcggcgc tgtcgaagat cagcagccag
     9001 cggcggtacg ggcggccgac gcgcagcgcc tcgtggacgg cgcggatccg gtcgcccagc
     9061 tcctggccga cgggcaggcc gaggcgggtg gccagctcgg cgagctgttc gcgggccgcg
     9121 ccccggttgg tggcgctgat ccaccagacg acgtcgtagt cgttgccgaa gcggtgggcg
     9181 tactcggcgg cgatctggct cttgccgacg ccggagatgc cgtacagggc gatccgggtc
     9241 tccagcggct ggccgaggcc gggcaccggg cccgccagct tgccgtgcag ctcctccagc
     9301 gcggtgtcgc ggccggtgaa gcggttgttg cggcggggga tgttccagat ctcgggcggg
     9361 tcgttgggga agcgcggcgc gttggcggcg gggtcggcgg ggcgccggcc ggcggtgggg
     9421 acgccgaggc ggttcaggac gcggcggttg gcctcgacgg cgtccaggtc gcgcaggtcg
     9481 gcggggcgca gtacggaggc ggtggcgggc agccgctggg tggcgacgct gacggcggcg
     9541 aaccggtcgg cgtggtccgg tacgacctcc tggagggcgg tcgtccactc gtcgtgcgtc
     9601 ttggggccca gcttgaagta ccagtcgtcg agcaccatca gcaggcggcc ctcggccgcg
     9661 agcagcccgg ccagttcctc ggtgaggggg ctgtcggccg gggggtccca gcggagcatg
     9721 gtggtgccgt gcccgagctg ttccagctgg tgcgaaatcc atgccgccca cggccggttg
     9781 aaccccgcat agctgatggt gatgtgttct gcggagccgg tggtaccgga ctgatcggcc
     9841 atgcgaccgt ctcctcggta tgcggtggtt cgcgcgtgcg cgagctggct gttcggcacg
     9901 atagcccaag tatcatcccc cgcggcgatg ccacgtcagg tcgtgtttgc ggtacgccag
     9961 ttgacgtatg caccggccgc ggcggggtgt ggccgcgtgg tcagtccacg cggacctcgg
    10021 cgtcgagccg ggcggcgatg tgccggatca cccgttccag gtcggcgcag tacacggacg
    10081 ggttacggaa gccgctgccg cctgcccggt agcgatgggc gtagttgccg ccgccgcaga
    10141 ccgtcatcag cgcgcaggcg cggcaccggt cgcacaggcc gtcggcgccg agccgccggg
    10201 cggtcattcc ggggtgtccg agcgcctcgt cgaagctgtt gcggaagacg tccagaccgg
    10261 tggcggcggc tccctcgtac gccgatttga gggagtcgac ctgctcgatc gcgccgtcgg
    10321 tgtcgaccac gacggccacg acgggtgaca ggccgaccgc ttcgctggtg ctggggcggc
    10381 ccagcagcag gccgatgatc tcggtgaaga ggcggacccg gggtgcgggg tcccgctcgg
    10441 cccaccacag gtcgaagacg gtgcacagcc agtcgccgta cggggtgcgg cccgccgggc
    10501 ccggcggcag cggcgggcgg atcgtccagt tggcgtgcgg gaggaggaag tcgagcatcg
    10561 gggggccgag tgcgcgcagc gagcggtaga cccgggcggg gtcggaggtg aggtcgatgg
    10621 tgcacaggat gcccgcgaag acgccggggc ggccggccag cagccgggcg gcgcgggacg
    10681 ccgcgggcca ggaggggcgg cccgcgtggt cgatgcggcg gcggttgagg cccggggtgc
    10741 cgccgtccag gctgaggccg atgcggaagc ccgcgccggc cagcgtgtcg agcaccggcg
    10801 gggtgagcag ggtgccgttg gtctgtacgc ccaggtgcgc gcggcagccg gcgggcaggg
    10861 cggcgcgcag ggcggccgcc tgggcgagga gcggtccggg gccggtgagc aggggttcgc
    10921 cgccgtgcag gtcgatgcgt atcgcgtcga ggccgtgggc gcgtacgtgc tccgcgatgc
    10981 gccgcgcggt ctggcgtacg gtgccgggcg gggcgtgcgt cgggcggtcg cgccagctgc
    11041 ggtcggggcc cgcgtagatg tagcagtagg tgcaggcgag gttgcagcgg ctgtgggtct
    11101 tcaggacgaa ctgccggaag ggcaccgcgg tccggtgcag gctctggcac accacgacgc
    11161 cgcccccctt gcccgcgtcc gacgtccggg caccccggag acggcccgct gtcgccatac
    11221 atggctcggc cgccgggaga catgcacagg gcatcgacaa ctggccggat acgcggcctg
    11281 gttgtccgga taccgctgcc ccgggcccgg tcggcgtacg gctctcagcg gtcggggtcg
    11341 gggttggggt cggggtcccc cgggccgtcg tcgtagtagg ccaccgcttc cgcggcggat
    11401 gcccagttgc gcagcaggag ggccgtcacc tcccccagca ccggatggcc cgtccgtgcg
    11461 gccagcgcag ccacatcgac accgccgaag tccggcagcg gctcggccgg cgggccggat
    11521 ggctcggccg gtgcggccgg ggccgtaccg atgacgggga ctgtcgccac gctgttctcc
    11581 tctgggcctg gtggacgggt gtctgcccgc gcgtccgagc acggaaacac ccggccggcc
    11641 gggtcagccg ttcatacgga cggatccagg gcgcgcatcc gctccctcgt gcgccgggcc
    11701 tcgggaccgc tctcctcgga cgcgcgctgc cactgctccc agctctcccg gtaggccacc
    11761 agcgccgcct gcggtcccgc cgtgtcctcc aggacgccgg cccgccggtg gtgggcccgc
    11821 gccgccagca gggggctgcc cgcgcggtcg gcgtcggccg cggcccggcg gtagcacgcg
    11881 gcggcgcggt cgtgccgctc ccgggagccg aagcgccggt cgagcgcgag ctggacgtcg
    11941 ccgacctcca gccaggcttc cgcgccgacg gccgggtcgt gcgagctgcg cgccgccagc
    12001 tccaggaccc agtcggcctc gtgcaggtcg gccagggagg gctggcggtc gtggcgcagc
    12061 cgcagggcgc gtccgaacag gaggcggtgg gagcccagtt cggggtcgtg cggcgcgacg
    12121 cggccgagtg cttcgcgcag gacgtgcacg gcctcgttcg ccagtcgttt gccctgctcg
    12181 ccggggggct ccagccgggc gcgcagcagc agggccgcgc cgcgttcggc gagcagggag
    12241 ctgtgctcgg gcgagtcggg ggtggtcagg cgcagtgcgg cggccagcgc gtcgatcgcg
    12301 gagtccaggg cgccggggtc gccggtgcgg gtgtgcacgg tccggtatgc cgtggccgta
    12361 cggctcaggc tctccgcctc cagggcgggg tcgcgcagtt cgcgggcgag ggcgcgggcg
    12421 cgctggagga cgggcagtac ggtgtccggg ccggtgccgg ggccgagcag cgagcgggcc
    12481 tgggccagct ccagcagcgt ttcgcagatc ttgcggtcgg cggagccgcc ccggcggcgc
    12541 agcaggaccg tggcggtgtc caggtcggcg gtggcgcgca gggcgagcgc cccggtgtgc
    12601 gtctcggtgc ccgtgtcctc cccggcggcg cggcgcgcct ggtccagcag gacgccgccg
    12661 cgcgcggcgt agatctcgcc gggcacctgt tcgccgctgg gccactgttc gaggagggtg
    12721 gtcagggcgt gctcggcgtc gccgagcggg tcgccgggcc ggccggttcc ggttccggtc
    12781 cgggcggccg ggggcagcgc ggccagccgt cgcagcactt cggtacgcag caccatgctc
    12841 tccaatacgc gggggtcgag caggctcatc agcccgcacg cggtgtcgag gtggcgcgcg
    12901 gcgtcctcca gcgcgccccg ttcaccgtcc gggtaccccg cggcgccgcg ttcctgcgca
    12961 ccggcgtagc gcacccgggc gagcacgatc agggctctga tgcgtgcctc gccgtccccg
    13021 tccggcgtct gcgccggatc cccgccgacg gcttccgctg ccgcccgtac cgcccgttcg
    13081 gcctcctcca gggcgtccgg ctgccgccac tcggcccagg cgtgcagcag cgcgcgggcg
    13141 aggtcggtgc ccgcggcggg cagctggcgg gccgcggcgc gcagcaggcg caccgcttcg
    13201 atcaagtcgc gtaccgtggc gtcctgttcg tagcgctcca gcagtgcggc gccctcggcg
    13261 gcgggcccgt cgggtgcgta cggcagctgg acgggtgtcc tgagggccgg ttcgaagcgg
    13321 cgcaggaccc gttcggatat ccgcgcgaac ggctcgggca ccgcgcgctg cccggtcgtc
    13381 ggttcccggc cgcttccgga gagcatggcg accgccacgg cggggaagtt gcgggcactg
    13441 cggccgaacg tgcgctcgat gtacagggag cagtgcttga ggaccagggc ggcctcgccg
    13501 gcgctcaggc ggctcagcag ctcgtcccgc acgccgggca cgaactcgta ccagggacca
    13561 cctgccacgc tctcccggcc gggcgcggcg gccgggtcgg gaagctgctc gatcaggccg
    13621 ctgagcagca cttccgcgag ctcggcgggg cccgtctggg gcagcatggc gcgctggacg
    13681 agctggatga cgggcagcgc gagcggtacg gccgacaggt ggacggccag gtgccgggcg
    13741 tccggtgagg cgctctgctc gaactcggcg accagccggt gcggttcggg gcgctccggt
    13801 cggcgcgtga ggtccgtgcc gaggccgtgg tcgcagcgta cgacggcggc ggcgccacgc
    13861 agcgagagac ccgactccgc cgcggccagc cgggcccagg agccgagggc ggcgggcgcg
    13921 gccgacagga ccggtacggc gcgctcacgg atgccgtcct gcgggcgccc ggctgcggag
    13981 ggggcgcggc ggcgccgggc gggcctgaag tccagggcac ggtaggggcc ctggcgccgt
    14041 acgagggtgc ccgcgacggc cgggagcagt gagcgcgccc acatccgctg cggcagcggc
    14101 tgcaccacgg cgagcggcgc gtcggccgcc caccggtaca gcagccgctg gatgcgcccg
    14161 tcgcgccaca gcgggcccgc gcagtcgctg acgacgaggg tgaggtggtg gcccgtgggg
    14221 tcgtgcagct ggtcggcggg gcgcagcggg gcgctccggt cggggcccgc cgcgacgccg
    14281 acctcgtcgc cgtgcgggtg gaggtagtgg accgtgacgt cgcggaaggc gccgacccgt
    14341 tcgcagacct gccgcaggtc gtgcagcatc tgctcccata cggccatgga ggacgagccg
    14401 tccatcagca ggcgcaggct cgccgcgcgg cggcggatgc cgcgcagcac gggaatgatc
    14461 agttcggcgt gcgcggagag gtcggcggtg gcgtcctcgt cgagctcctg gcgggccggg
    14521 gcgaccggcg ggtggtagcg ctggaccggg cgcagggcgc gctggagcgg cagcagcccg
    14581 gggaaggcgg aggcgacggg gatgccgacc tcgcccagcc ggccctggcc ggggccgagg
    14641 gggcggtcgt ccggcgcggg cagcagctcc acctccgggc ggcgggggcg gtcgcgcgcg
    14701 gcgggttccg tacgggacgg ggcgtcctgg gacggctcgc ggctgcgggg gtccacggag
    14761 aaagtggccg gttttggcct ctgcgtggcg gacggaacgg ccccttcggc gggttccccg
    14821 tcgtcgcggg gcggcgcggg ggtgatccac cgggccagcc acagcgcgtc cgccatggcg
    14881 cgggcgtcgg cgggcagccc ggccgcgcgc agccgcgcga cgatctcacc gagagggccg
    14941 aagcccggtc cgccggccgg caccgcggat cacctggtcc gatccagggg ccgcagcagt
    15001 tcggccgtca ggcgccgccg cgtctcctcc tcgtcctcgt ccgcccagcc ggccttctgc
    15061 gtcaggtgga tggcgttgag cagctggtcg acggcgcgta cgtcgccggg ctcgcggtcc
    15121 aggaagcggt cgatcagcga ctcgtagtcg gcggcggcgc tctcgccgaa gtgcgcccgg
    15181 accatgtccg cgagccgctc cttgtcgggc gtggggatgt tcagatggat gcagcggcgc
    15241 agcagcgggg cggggaagtc ccgctcgccg ttgctggtca gcacgatgaa cgggaaggcg
    15301 cggcagcgca cccggccgtc ccgcacggtg acatggccgc cgtcgtcacc gagcaccggc
    15361 acctcggggg cggatccggc cagccgctcc agctccggaa tccggaactc cccttcctcc
    15421 agcacgttga gcaggtcgtt cggcaggtcg atgtcgctct tgtccagctc gtcgacgagc
    15481 aggacacgcg gtttcgcggc gggcagcagg gccgtgccca gcgggccgag gcggatgtag
    15541 cggccgatgc cgccgcccgg ctcgtcctgc ggctccgggc tccccccgcc cgggaccgga
    15601 ccggcctgcg gccgggccgc gcgggcgatc tggaggtcct ggaggcggcc gatggcgtcg
    15661 tactcgtaca gcccgtcgcg cagcgaactg cggctgacga tcgaccagtt cagcacccgg
    15721 cccaggccca gctcgtaggc gaccgaatgc gcgagggtgg acttgccgct gcccggcgca
    15781 ccggtgacca gcagcgggcg gcgcaggtag agcgcggcgt tgaccagctc acgctcggtc
    15841 tcccccggcc ggtggtagct ggcctcgcgg cgctgtacgc cgagcctgcg ctcggaggcg
    15901 tggtcgaggg cggcgggcgg cgccaccggc ggaccgccgt cgaaatcccg ccacggaggg
    15961 ggcggcggta actgctcgat gccgtcgtgc ggagcccccg cgccacggta gatgagccag
    16021 tcgctcacgt cggaactcct cgtcgccggc cggccatcgg gcagaggcga aggggccgcg
    16081 gaagagcaac cccggcaagc gtcggcatcc gcttcccgcc ctccccggac ccgtccccct
    16141 agcaatctct cacgacgcta ggacagtagc cagccggacg gaaggatacg gggcgttttc
    16201 cggtctccag ggacgtcatt ggggcgacaa ttgcgcggcc tgggagaaga gttgggggat
    16261 cgggttgccc gggtcgtcgt agaggagcac gaggtcgcgg gcccaggaga cgccgccctc
    16321 cgccgccttg gcccgcagct cacgcaccag ttcgggcagc tcggcgaccg acttcggcgc
    16381 ccccagcagc tgccgcacct cccggtggaa ctcgtcgcac acccggtcgc agtcccgctc
    16441 gtcgtgcccc tccgccagcc acagcgcgac cgggtggccg gtgtccagcg cccagccgac
    16501 agcctccagc ccggtcccgc ccgccaccga ccggcacagg gccggcaccg cgccctcccc
    16561 cgcctcctcc agcagccgcg acagacccga cgtcgaggcg cgggtaccgg ccggcacccg
    16621 cagcccggtc agccgccccg ccgcggccag gccctgccag cgccgcagcc acgccgggtc
    16681 cacctcctgg cgccgcccct ggtcgcgcag caccaccgcg cgcgccgggc ccagcgggcg
    16741 caggcgcgcg gcacggcgcg tcgaggccgg tacgcgccag cggtccgccg gtgtgtgcca
    16801 gcgctcctcc ggcaccgcga cctccaggcg cacccgggcg ccgcccgccg cgtcgtcggc
    16861 ccgcagcaga cgcggaccga gccgccggag cacctggtca acggcctgct cgaagctcat
    16921 cccgtcccgc gactcctgga tctccacgcg ctgccaccgg ccctgcccgt acccctcgct
    16981 gaccgaccag ttgaacagct gccggccgcc catgccgtcg tagaacagcg gctcgaactc
    17041 caccagcagc gcgtcgggac ggcgccgtac cggcccgatc cgctcccgat ccctgggcag
    17101 cagcacgacc gccttggccg tcacgaacag ttccagccgc tccgccgccg cgcgcatcac
    17161 cgcacccgcg tcgccggggg cctcacgcgc ctcgtccgcc gtccgctgcg cgacgatgcg
    17221 caggtagtgc acgaaggcac acagctccgt gtacgggtcg ctgccctggt acagcgcgcc
    17281 gtgcccgtcc cgccaggtac gcagcgtcca cggcccggcc cgccccgtac ggccctccgg
    17341 gtccgcgcgg cccagcgcct cggcgaccgc ggcggccacc acgagcgggt cgcacggcgc
    17401 gggcagcgac gccagcaggt cgagcgcctg gagccgctcc tgcacgcccc acagccggcc
    17461 gcggcccgac atgatcgcgt gctgggcgtc gaaccacgtg ggctcgcccg gcccgccgag
    17521 gtcctgcccc gcccagtgcc agcggtcgtg caaacccatc agcgcgtggt acgggtcgtc
    17581 gccgagcccg gtggcgcccg gcacgagatg gtgcggcgcc agcccgcgca actcggtgac
    17641 cggcaccgcg aggccgagcc ggtcctcacg gtgactgccc ttgacgatgc cgacgacctc
    17701 gccgcggtcg cagtccagca gcggcccgcc ggacgcgccc ggggtcaccc ggacatcgct
    17761 gccgaactgg aggccgcggg cgtcgcgggc accgaagcgg acggcgatga aggggtggac
    17821 atcggcggcg gtgtccggac cgccctcgcc gtacgccgct tccgccgcgc cgggccggtc
    17881 ctgatcgtga ccgcggaaga tgaacgcgtc ctccaggagc gcggccggct ggtcactgag
    17941 ccaggcacac gggtgcggcg tctccgggtc gagaagccgc aggagcgcga ggtcgacgcg
    18001 cggggtgggg gcggcgggcc cagaggtgtg cccggcgtcg ccgagggcag tggccgagcc
    18061 cggtctctca tccacagccg ccccgtacgg cggcgcggcc tcccccgcgg gcgccgggcg
    18121 gctcaggtcg tactccaggc gcgcggcgac cacccggccg ccgaacgcca cgcccacctc
    18181 cccggccggg cccgtcggac ggcgccggcc gtccccgctc gcgagcacat gcgcgcaggt
    18241 cagcacccac ccgggagcga cgaacacccc actgccccac aacggagccg gccggacacc
    18301 gggcgccggg cggatggcga cggtggcccg gcccgcatgg cccaggaggc gcgcgtacct
    18361 ctcgcggtcc gcgcgctcac cgcgtacgga cccctgaccg ccttccgggg ccgccatcac
    18421 gcacccgaat cgtgcggccc tcggccgtcg ccccggccgc catccggaat acggccctca
    18481 cccggcgcct ccttgcgccg ccacgtgagc gtcaccgaca ggttcgcctt ggcctcaccg
    18541 tcggccagca gcgccaccgc ccggcccggc ttggccgcca cctccacgcc gaagctcaca
    18601 ctggtctcgt ccggcgccac ccgctccgtc gcggcgcgca ggctcgccgc gaccccgccg
    18661 accagctccc gcaggccctc cacgcgggct ccgagcgctt cccacgcccc cacgtcgtcg
    18721 tattccccgt ccggctcccc cgcgacgtcc agccgggaca cccgggccca gacctccgtc
    18781 ccgtcgggca gctcgatgag atgtgcgcga tcacgcatca cggcctcctg ctccccctga
    18841 gcggcaatgt cgcactgccc cagggccgtt gacaggtgat caggttagcc ccagggtgcg
    18901 agtgacgcga ggggtcgcga cgcctgccta tcctggccgg gaacgtcccg aaaacctggt
    18961 ggagagcacg tgtatttcac ggatcgcggt atcgaggagc tggagagccg gcgcggcgag
    19021 gaagaggtca ccctaggctg ggtggccgaa cagctgcgca ccttcgtcga cctcaaccct
    19081 gacttcgagg tccccgtcga acgcctggcc acgtggctgg cccgcctgga cgacgaggac
    19141 gacgactgac gcgcagcggc ccggtgggag tgcgggttgt gcgcggtctg gccggtggtg
    19201 gggtgggctc gggcccacgc aggggtcact cctcgacacc gtgtacgtca acggtgacta
    19261 catagtgaac ccagataccc ggctgctctg cggggagacc cctgcgtgga cccgagcccg
    19321 gccggattgc ggctctcccg ccatcgtggc tgcaataccc ctgcgcgcag cgcaggggcc
    19381 ggtgcccgcc gcgcgcagcg cggtggctgg gtcaggcacg ccgtgggtgc gcacccgccg
    19441 ccgggtgacg ccatggccgc gcttgccccc gcgaccgtga gcttcaccgc taggtgggcg
    19501 ccgatcaggt tggcgtgggt gcgcacctgc cgccgggtga cgccatagcc gccccccgcc
    19561 tcccccccgt gagcctcacc gccaggtggg cgggcacggc ggtgatcgaa gaattccccc
    19621 cagctggccg cagtcgccaa acaacgtgag ggggtgcgta gggggccatc cccgcagagc
    19681 agccgggtat ctgggttcac gactacatca ccgttgccgt acacggtgtc gaggagttgg
    19741 ccccctgcgc gcccccgccc cacagcgaaa gccatacgac cccgcgcgcc agcgaacccc
    19801 ctcgcgcgaa gcccgaagcg caatgcgccc accccgcaca aggtgaacca caaaccgaaa
    19861 accgcgcgcg cagcgcgccg cacacttgga accccccgca gcgcgatata tcgtgttggc
    19921 agatacgcga tatgttgcgt tgttacacca ggggaggcca ggacatgccg gaccgaacag
    19981 agtggtcggt ctccgatcca cgcacgctgg agatcgagaa ctccgtaacc gcgctcgaag
    20041 tgcgcatcgt cggcggcacc gtcaacgtcg tgggcacggc agacgccggc ccggcccgcg
    20101 tcgaggtcgg cgaactgtcc ggcccgccgc tgaccatccg ccgggaggcc ggcacgctca
    20161 cggtcacata cgacgatctg ccctggaagg gttcgctgaa gaggatcagc cgcgcggcct
    20221 ggaaccgcag cgcggtcgtc tcggtcaccg tgcccgccgc cacccgggtg gcgatcggca
    20281 cggtcggcgc gagcgcggtg gtctcgggga tctcgggacg tacggagctg cgcggcgtct
    20341 ccggcgacag caccctcgtt cgtctgaccg gcccggtgcg ggccgagacg gtctccggcc
    20401 gggtcgaggg ccaggccgtc accggcgacc tgagtttcca gtcgatttcc ggggatctga
    20461 cgctcgtcga cggctccggt ggcaccgtga aggccgattc ggtcagcggc gacatggtcc
    20521 tggatctcga tccggcagcc gagggcgcgt tcgtccggct ggccacggtc tccggcgagg
    20581 tcgccatccg gctgcccgcg ccgggcgaca ccgaggtgga ggcgaacacc accagcggca
    20641 tggtcacgaa cgccttcgag gatctgcgcg tcagcggccg gtggggggcc acgcggatca
    20701 cgggccgcct cggctcgggc agcggcacgc tgaaggtcac cacggtctcc ggggccttgg
    20761 ccctgctgcg ccgcccgccg tccgaggagc gggccaccgg gccgcacgcg gaggccgggg
    20821 ccgcgcgcaa cggcaccggc gaaaccccct cccccgccga caagaaggtg ctctgacaac
    20881 catgcctccc gtcttcgccc atggccgcct ccgcctctac ctgctcaaac tgctggacga
    20941 ggccccgcgg cacggctacg agatcatccg actcctggaa gagcgcttcc aggggctgta
    21001 cgcgccgtcc gccggcacgg tctacccgcg gctggccaag ctggaggccg agggcctggt
    21061 cacccacacc accgagggtg gccgcaaggt ctacgcgatc accggggcgg gccgcgccga
    21121 actggcgaac cggggcggcg agctggccga cctggagatg gagatccggg agtcggtggc
    21181 ggcgctggcc tcggacatcc gggaggacgt gagcggctcg gcgcggaatc tgcgccgtga
    21241 gatgcgcgag gcggcccagc aggcgcgcga cagccggtcg ggcgggcgtg gcgcggccga
    21301 ggggaacggc ggcgaggagc acgggttccc ggaggccgcc gactacttcg agggccgctt
    21361 cggcgacaag gaggcctggc ggcaggcgaa ggaggagttc cgccgcgcca aggaggagtg
    21421 gaaggagcag gcccggcggg ccaaggagga gagccggcgg gcgaagcagg acgcgcagcg
    21481 ggcccgtaaa caggcccggg acacgcagct gttcgtgcgc gacgaggtgc agcaggccat
    21541 caagcgcgta caggaacagg cccaggagca
//
