LOCUS       NZ_LWKZ01000001        20273 bp    DNA     linear   CON 28-MAR-2024
DEFINITION  Streptomyces sp. CB02923 scaffold1, whole genome shotgun sequence.
ACCESSION   NZ_LWKZ01000001
VERSION     NZ_LWKZ01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CB02923
  ORGANISM  Streptomyces sp. CB02923
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 1452656)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra, Yang,D., Teng,Q., Crnovcic,I.,
            Li,X., Rudolf,J.D., Lohman,J.R., Gansemans,Y., Zhu,X., Huang,Y.,
            Zhao,L.X., Jiang,Y., Van Nieuwerburgh,F., Rader,C., Duan,Y. and
            Shen,B.
  TITLE     Strain Prioritization and Genome Mining for Enediyne Natural
            Products
  JOURNAL   mBio 7 (6), e02104-16 (2016)
   PUBMED   27999165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1452656)
  AUTHORS   Yan,X., Ge,H., Huang,T., Hindra,H. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-APR-2016) Department of Chemistry, The Scripps
            Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2016
            Assembly Method                   :: CLC NGS Cell v. 8.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001905005.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 20:56:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,128
            CDSs (total)                      :: 8,049
            Genes (coding)                    :: 7,904
            CDSs (with protein)               :: 7,904
            Genes (RNA)                       :: 79
            rRNAs                             :: 2, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 145
            CDSs (without protein)            :: 145
            Pseudo Genes (ambiguous residues) :: 0 of 145
            Pseudo Genes (frameshifted)       :: 32 of 145
            Pseudo Genes (incomplete)         :: 128 of 145
            Pseudo Genes (internal stop)      :: 11 of 145
            Pseudo Genes (multiple problems)  :: 22 of 145
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:21:38
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 258975
            Orig. end                         :: 279248
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LWKZ01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20273
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..20273
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20273
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10273](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10273
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     misc_feature    113..126
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.93"
                     /tool="antismash"
     gene            complement(153..1070)
                     /gene="thrB"
                     /locus_tag="A6A06_RS01045"
                     /old_locus_tag="A6A06_01040"
     CDS             complement(153..1070)
                     /EC_number="2.7.1.39"
                     /GO_function="GO:0004413 - homoserine kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009088 - threonine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thrB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018536102.1"
                     /locus_tag="A6A06_RS01045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_01040"
                     /product="homoserine kinase"
                     /protein_id="WP_073757841.1"
                     /transl_table=11
                     /translation="MAGPAFRAAAVRVRTPATSANLGPGFDAFGLSLGLYDDVVVRVAD
                     SGLHVDIAGEGAETLPRDESHLLVRSLRAAFDLLGGQPRGLEIVCANRIPHGRGMGSSS
                     AAICAGIMAARAVTIGAEQKLDDAALLELATEIEGHPDNVAACLLGGFTLAWTDTGSAR
                     AIRLDPADSIVPVVFVPGKPVLTETARGLLPRTVPHVDAAANAGRAALLVEALTRRPEL
                     LLAATEDRLHQEYRAPAMPGSVALVNRLRADGVPAVISGAGPTVLALVQEDAADKVAGL
                     AGEGWAANRLALDAAGTSVLPLAG"
     gene            complement(1450..2526)
                     /gene="thrC"
                     /locus_tag="A6A06_RS01050"
                     /old_locus_tag="A6A06_01045"
     CDS             complement(1450..2526)
                     /EC_number="4.2.3.1"
                     /GO_function="GO:0004795 - threonine synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009088 - threonine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thrC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018087402.1"
                     /locus_tag="A6A06_RS01050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_01045"
                     /product="threonine synthase"
                     /protein_id="WP_073757844.1"
                     /sec_met_domain="PALP (E-value: 3.6e-72, bitscore: 239.5,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAISTASRQWRGIIEEYRDRLPVGASTEVVTLREGGTPLVPAQV
                     LSERTGCEVHLKVEGANPTGSFKDRGMTMAITRAKEEGAKAVICASTGNTSASAAAYAV
                     RAGMVCAVLVPQGKIALGKMGQALVHGAKILQVDGNFDDCLTLARGLSEKYPVALVNSV
                     NPVRIEGQKTAAFEIVDMLDDAPDIHVLPVGNAGNITAYWKGYQEYAADGLASRTPRMW
                     GFQASGSAPIVRGEVVKDPHTIATAIRIGNPASWQFAERARDESGGAIDEVTDRQILAA
                     YRLLASQEGVFVEPASAASVAGLLKAADEGKVDPGQRIVCTVTGNGLKDPDWAVAGAPQ
                     PVTVPVDADAAAERLGLA"
     gene            complement(2535..3863)
                     /locus_tag="A6A06_RS01055"
                     /old_locus_tag="A6A06_01050"
     CDS             complement(2535..3863)
                     /EC_number="1.1.1.3"
                     /GO_function="GO:0004412 - homoserine dehydrogenase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006520 - amino acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014176391.1"
                     /locus_tag="A6A06_RS01055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_01050"
                     /product="homoserine dehydrogenase"
                     /protein_id="WP_073757846.1"
                     /transl_table=11
                     /translation="MMRTRPLKVALLGCGVVGSEVARIMTTHADDLTARIGAPVELAGI
                     AVRRPDRVRAGVPAELITTDATELVKRDDVDVVVEVIGGIEPARTLITTAFEHGASVVS
                     ANKALVAADGAALHAAAEANGADLYYEAAVAGAIPLVRPLRESLAGDKVNRVLGIVNGT
                     TNFILDKMDSTGAGYSEALDEATALGYAEADPTADVEGFDAAAKAAILAGIAFHTRVTI
                     DDVHREGLTEVTASDIASAKRMGCTVKLLAICERAADGASVTARVHPAMIPLTHPLASV
                     REAYNAVFVESEAAGQLMFYGPGAGGSPTASAVLGDLVAVCRNKLAGTTGPGESAYTQL
                     PVGPMGDVVTRYHISLDVADKPGVLAQVAMVFAEHGVSIDTVRQQSKDGGAARSGEAEN
                     GGEASLVVVTHRAADAALSSTVGALRDLDTVRGVASIMRVEGE"
     misc_feature    3885..3900
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.41"
                     /tool="antismash"
     misc_feature    complement(3910..3924)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.21"
                     /tool="antismash"
     gene            complement(4066..5457)
                     /gene="lysA"
                     /locus_tag="A6A06_RS01060"
                     /old_locus_tag="A6A06_01055"
     CDS             complement(4066..5457)
                     /EC_number="4.1.1.20"
                     /GO_function="GO:0008836 - diaminopimelate decarboxylase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009089 - lysine biosynthetic process via
                     diaminopimelate [Evidence IEA]"
                     /codon_start=1
                     /gene="lysA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Orn_Arg_deC_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Orn_DAP_Arg_deC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1264: diaminopimelate decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005480288.1"
                     /locus_tag="A6A06_RS01060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_01055"
                     /product="diaminopimelate decarboxylase"
                     /protein_id="WP_073759601.1"
                     /sec_met_domain="Orn_Arg_deC_N (E-value: 2e-68, bitscore:
                     226.6, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 4.2e-15,
                     bitscore: 52.1, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRSAHPAGPRHGDVLPEGHYAAPPADLNSLDPRVWARTVERNAD
                     GVVTVGGIDVSALAEEFGTPAYFLDEDDFRSRCRAWKEAFGEEADVFYAGKAFLSRAVV
                     RWLAEEGLNLDVCSGGELATALAAGMPAERIALHGNNKSTEEITRAVEAGVGRIVLDSF
                     QEIVRVAHIADRLGKRQRVQIRVTVGVEAHTHEFIATAHEDQKFGIALAGGQAAEAVRR
                     VLKLDGLELTGIHSHIGSQIFDMAGFEVSARRVVQLLTEVRDEHGVELPEIDLGGGLGI
                     AYTSDDDPREPHEIAKALGDIVTRECAAAGLAVPRLSVEPGRAIVGPTAFTLYEVGTVK
                     ELDGLRTYVSVDGGMSDNIRTALYDAEYSVALVSRASDAPPMLSRVVGKHCESGDIVVR
                     DAFLPADVAPGDLLAVPATGAYCRSMASNYNHALRPPVVAVRAGAGRVIVRRETEEDLL
                     RLDVG"
     gene            complement(5521..6606)
                     /locus_tag="A6A06_RS01065"
                     /old_locus_tag="A6A06_01060"
     CDS             complement(5521..6606)
                     /GO_function="GO:0004814 - arginine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006420 - arginyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012379030.1"
                     /locus_tag="A6A06_RS01065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_01060"
                     /product="DALR anticodon-binding domain-containing protein"
                     /protein_id="WP_073757848.1"
                     /transl_table=11
                     /translation="MTPAELSRAVLRSVRGAVEDGELSVTVPERVVVRVPARGGGGGAA
                     DLACSVALQVAKEAGRPSREVAAMLRERLAGVSGIAGVEIAGAGFLNVTLTGAARAGLV
                     WSVLAQGREYGNTAGRGDGQEPGRGCGPVGLRAAAGVRAAVVAEALERILPAGGITAKA
                     EPRGEGSSPHSAVARGRTEEVAPHPVESHPHSPHQDWRTLTARLGPDEARWVLLRVAQQ
                     DAVRLPERPVQRESNGRFRVQYAYARTCAMTRNARDLGFAAEPGDMGDGRAVREVWAAV
                     AEYPGVVEAAARHRAPDRVARHLEVTADAWLRCHDVCPPLPVGEEKPSAVHRARLALAE
                     AAGTVLANGLHLLGISTPERL"
     gene            complement(6703..7167)
                     /locus_tag="A6A06_RS01070"
                     /old_locus_tag="A6A06_01065"
     CDS             complement(6703..7167)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010984353.1"
                     /locus_tag="A6A06_RS01070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_01065"
                     /product="response regulator"
                     /protein_id="WP_242440510.1"
                     /transl_table=11
                     /translation="MPGLSGRVLVVDDNKVIRQLIRVNLELEGFEVVTAADGAECLDIV
                     HRVAPDVVTLDVVMPRLDGLQTAARLRADPRTRGIPLAVVSACTHVEVESGQALGVDAF
                     LAKPFEPMDLVRMVRRLMSRGGEPGGEGLADADADADAEGDAESVVRPAG"
     tRNA            7357..7428
                     /anticodon=(pos:266365..266367,aa:Arg,seq:ccg)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="A6A06_RS01075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="A6A06_01070"
                     /product="tRNA-Arg"
     gene            7357..7428
                     /locus_tag="A6A06_RS01075"
                     /old_locus_tag="A6A06_01070"
     misc_feature    7629..7644
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.39"
                     /tool="antismash"
     gene            complement(7640..9016)
                     /locus_tag="A6A06_RS01080"
                     /old_locus_tag="A6A06_01075"
     CDS             complement(7640..9016)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1077: phage integrase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010040209.1"
                     /locus_tag="A6A06_RS01080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_01075"
                     /product="site-specific integrase"
                     /protein_id="WP_073757852.1"
                     /transl_table=11
                     /translation="MKTTDVRIWGVRPKSRQGRDTYEVRWTVAGREISRSRRTKGLADK
                     LRAQLLMAQDNGEQFDTVSGLPPSMEEQGPLLTWYAFALKYLRMKWPHSAPNYRDEINE
                     ALSGVTKALAPMHAGRPSDAAMQRALRDWAFVLPGPDERSIPPEARSVIDWLVKHSPPL
                     ADLNKPAVMRGVLEALKLKLNGEAAGSETFKRKRKVLVNALNYATELGEFEENPVHAVS
                     VKRPPRVIPVDPRVVANPQQASNLLGAVSYVGGYNRARGRRLVGMFGGMYYAGMRPAEA
                     VGVAIQDCHLPAEGWGLANLHRTRPTAGKKWTKSGEVHDDRGLKNRAQGEVRPTPLPPV
                     LVAMWRDSIDTFGTADDGRLFFNERGGLVGSSTYSRVWGEAREFALPPDLVNSPLADCP
                     YDLRHSALSTWLNAGVDPTEVAERAGNTVEVLLARYAKCLHGRHLVANQRIEKLLLEYA
                     "
     gene            complement(9013..9186)
                     /locus_tag="A6A06_RS01085"
     CDS             complement(9013..9186)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674985.1"
                     /locus_tag="A6A06_RS01085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_073757854.1"
                     /transl_table=11
                     /translation="MTVPEVLAELNGVSRRTFYRWRELGTGPTVLKLPNGELRVWRSAL
                     TRWLEEREEAAA"
     gene            10001..10273
                     /locus_tag="A6A06_RS01090"
                     /old_locus_tag="A6A06_01080"
     CDS             10001..10273
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017239.4"
                     /locus_tag="A6A06_RS01090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_01080"
                     /product="PqqD family protein"
                     /protein_id="WP_073757856.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 2.8e-09,
                     bitscore: 33.2, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLTDEGGAILGERTGRWAYLTPTASATVMLLLASTSQEEAAGQYA
                     ERYGTGVQQAAADVRTVADTLAARGLAHTGQEPVRTHRRWWGWRP"
     aSDomain        10007..10219
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_A6A06_RS01090_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="6.20E-11"
                     /identifier="RREFam002.1"
                     /label="A6A06_RS01090"
                     /locus_tag="A6A06_RS01090"
                     /protein_end="73"
                     /protein_start="2"
                     /score="33.2"
                     /tool="antismash"
                     /translation="TDEGGAILGERTGRWAYLTPTASATVMLLLASTSQEEAAGQYAER
                     YGTGVQQAAADVRTVADTLAARGLAH"
     gene            complement(10646..12043)
                     /locus_tag="A6A06_RS01095"
                     /old_locus_tag="A6A06_01085"
     CDS             complement(10646..12043)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016909038.1"
                     /locus_tag="A6A06_RS01095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_01085"
                     /product="transcriptional regulator"
                     /protein_id="WP_242440511.1"
                     /transl_table=11
                     /translation="MPNTLLSHFMERAQLTNAQLAQAVTAGARATGHRDINPDESRVRR
                     WRGGECPRQPVPQLIAQVLGARLALPLTPADVGLPGPLPPTGLGTDLPWQHTATIAAIA
                     HLTRSDLMLPHTRTSHDATQIQAADALLEPLRRWPSAKPAALPNAPRTGTLGTAQIASI
                     EALTAAFRDADNRHGGVLSRRAVVAQMSEINDLLATASYTEATGRRLFRAVADLGSVAG
                     WMSFDAGAHVSAQRLFVTAVHAASEGGDRQLGAHILQCMARQMSHLGHVEDALELIALA
                     QYGARRHASPGTRAVLAALHSRFSAMCGDLEESQRAAQEAEDAFTRIRPGDEPPHTAFF
                     DEAELSATLGIAHQIAAKQTSGHQRTHRAEQSLTLLTNALRLRPAGRVRSRAFDHIGLA
                     RTHLAVGELAGACQEAATALTIAEGLHSTRIADRLSELHEETEPHASSSDISALRERLE
                     DAVTTAR"
     gene            12304..13539
                     /locus_tag="A6A06_RS01100"
                     /old_locus_tag="A6A06_01090"
     CDS             12304..13539
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014046967.1"
                     /locus_tag="A6A06_RS01100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_01090"
                     /product="hypothetical protein"
                     /protein_id="WP_073757860.1"
                     /transl_table=11
                     /translation="MELPFIVVDQLTPQQERDWHAYFGTPGADRPRDIEEGIWRRTQES
                     ATAPQSGWQPGDARRRMVHYRYRYGLATTTGAPALALRQLYLYHHAAAPAEEIGAHWEA
                     VRAALREGGWKPEGGAWVRGDLHVTPTLHSAPHPEDLRAGRTLPHGYACLDVQVTSSGY
                     VPPPATRRRPWDVLASGVRRKAAPGTFRRIPDLAPLADYLPFQVEIGCGTSWEAGIPAL
                     HRLHEVYRVTTREDDAPGTRDFVLRPQNDPLLREILTAPEEKVEECVELYRACFLARPT
                     PALYALKELHDAGLMAGPVITNNFDVLPARVGLRECFMRRYDQTVPDVEFVDGAKALLV
                     VGLHADRRQVAARARERGMQVVHCDPEGFWHDGVFHPYPLEGPQDGDLVCTAPAGEALP
                     DLAQHLLEKIAA"
     misc_feature    complement(13634..13649)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.37"
                     /tool="antismash"
     gene            13663..14985
                     /locus_tag="A6A06_RS01105"
                     /old_locus_tag="A6A06_01095"
     CDS             13663..14985
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1152: nucleotide sugar dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007457733.1"
                     /locus_tag="A6A06_RS01105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_01095"
                     /product="UDP-glucose/GDP-mannose dehydrogenase family
                     protein"
                     /protein_id="WP_073757862.1"
                     /transl_table=11
                     /translation="MRVSVIGCGHLGIPHAAGMAEIGHEVIGVDTDQAKIDTLNRGESP
                     IYEAELPELLTRHTASGRLRFTTSLAEAAQAADVHFLAVGTPIDADGRGYDMGQVFGAA
                     RALAPHLTRPTVIIGKSTVTPGTTAKLAGLLARHAPAGRDVEVVWNPEFLREGHAVADT
                     LRPDRIVAGVPSHRAEDVIRELYAPIDAPLVVCDPPTAEMIKGAANTFLGLKISFINAV
                     ADMCAASGADVATVAATIGMDPRIGVGGMSPGIGYGGGCLPKDIRAFTAAARQLGADDA
                     AGLLRAAEIINEHRPAAALDLIAQALDGRLAGRDVTVWGAAFKPGTNDVRESPALAVAR
                     LLQDRGARITVHDPHAVPTALARHPELEYTNDLAASVKGADAVVLATEWPHYRDADPAA
                     LRDLPAEPLIVDLRTALDPHRWTAAGWCVHQLGRPAVRTPH"
     gene            15030..15383
                     /locus_tag="A6A06_RS01110"
                     /old_locus_tag="A6A06_01100"
     CDS             15030..15383
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007457732.1"
                     /locus_tag="A6A06_RS01110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_01100"
                     /product="hypothetical protein"
                     /protein_id="WP_242440512.1"
                     /transl_table=11
                     /translation="MTTHKLLDVLDLDTIERLAAVCRQAGSDLPDGELKALQVGKVGEE
                     GGEAMHQLHGLKGLTTCDCKQHSWDGVMNDLGGAVLASLIAMVYIEPDSWRTTLTEVLH
                     RRTRRGREHTATA"
     gene            15475..15888
                     /locus_tag="A6A06_RS01115"
                     /old_locus_tag="A6A06_01105"
     CDS             15475..15888
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014628155.1"
                     /locus_tag="A6A06_RS01115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_01105"
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_073757864.1"
                     /transl_table=11
                     /translation="MGVAAAIRNSDGAYLLHLRDDIPGICWPGHWSFLGGQMEADETPH
                     EAITRELQEEAGLNLPDLHSLATVQQGNGRPDIEVFTASWNGDATRIEVTEGIMLAWFH
                     PRILPRLRVPPWCVEAIHLHHATPQQTNPPVPP"
     gene            16034..16165
                     /locus_tag="A6A06_RS43435"
     CDS             16034..16165
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A6A06_RS43435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_274535864.1"
                     /transl_table=11
                     /translation="MPACEVALYRSATSTLERLGVQVLTIDTNVLTPRRQPPGSPAP"
     misc_feature    16080..16095
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.36"
                     /tool="antismash"
     misc_feature    16178..16198
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.84"
                     /tool="antismash"
     gene            16224..16667
                     /locus_tag="A6A06_RS01120"
                     /old_locus_tag="A6A06_01110"
     CDS             16224..16667
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016908357.1"
                     /locus_tag="A6A06_RS01120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_01110"
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_073757866.1"
                     /transl_table=11
                     /translation="MPTATPVIDTHVILRDGDKILLSQRGSPYGYGRWHLPSGKLDTGE
                     SLPVGAAREAHEGTGITVDPAHLRHVHTVHHQQSPGDERIGFFFLATRWEGEPTNREPD
                     KCLDLRFFDVHDLPEDIIEYPAAGLYGYLTNPTPLTLHGWPQH"
     misc_feature    complement(16863..16877)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.75"
                     /tool="antismash"
     misc_feature    complement(16945..16960)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.1"
                     /tool="antismash"
     gene            16946..18010
                     /locus_tag="A6A06_RS01125"
                     /old_locus_tag="A6A06_01115"
     CDS             16946..18010
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018546155.1"
                     /locus_tag="A6A06_RS01125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A6A06_01115"
                     /product="NAD-dependent epimerase/dehydratase family
                     protein"
                     /protein_id="WP_073757868.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 1.9e-05, bitscore:
                     20.1, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRILVMGGTWFLGRAVVEEALRRGWEVSTFNRGRSGQDVPGVRPV
                     RGDRTAAEDLAELASHGPWDAVVDTSSAALPPKDVLTGARALKAAAERYVYVSTVNAYR
                     GWPGDPLTEASELLDGPPDADADYGRLPEDWTGPDWYYGRQKAGAERAVLEAFGEKCSV
                     LLRPGVILGPGEYVGRLPWWLRRAERGGRVLAPGLPGKSIQPVDVRDVAVFALDQAAAP
                     VGGAYNVVAPIGRETMGGFLNACLEVTGHRGELSWVPDAFLVKAGVEQWTELPLWRTHA
                     GVWNIASDGAQAAGLVCRPLAETVEATWRWLRDGGLPVAHPRADEHGIAARKEERLLEE
                     FAERVASGFEGERL"
     gene            complement(17984..19000)
                     /locus_tag="A6A06_RS01130"
                     /old_locus_tag="A6A06_01120"
     CDS             complement(17984..19000)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A6A06_RS01130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A6A06_01120"
                     /product="hypothetical protein"
                     /protein_id="WP_242440513.1"
                     /transl_table=11
                     /translation="MTARDAAAHAEDAASLTVPDITLDRLRDTILDIARTYNSTSPPEV
                     YRTAKELLLDTQEKLDRTQVPRQREHLYLTAGQAAAMLSAVCFDLGALQPAVQHSRTAI
                     LYGQVIEHGPLQAYAHGALAFLAYWSGRPAAALTLVRTAQGFGGLGATACSRLAVIEAR
                     THAHLGDHEQAVQAIRDSLDIPHSNRDDLHDDIGGEFGFSSERLAMSNATTYLLIGDAT
                     GAEEAATQALHLLDQRDAGSRPLLISSQAATDLARARLLRQELDGACDALAPVFDVPRD
                     WRGAGVLERLAAARAQLTRPVFRTAAKATELGERIEEFSASSVSRNFRGSEPLALEP"
     misc_feature    complement(19426..19441)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.28"
                     /tool="antismash"
     misc_feature    19428..19443
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.28"
                     /tool="antismash"
ORIGIN
        1 actgctccaa gcagtttggg aggctcccgg aagaaaagtg gtcccgatgg gggacacgga
       61 gtaccgcgcc gctgaggcgt cacgtactca cttgaggtta acactaccgg atccaacaaa
      121 cattccccct ctcgaagacc ggcaatcgtc gatcacccgg cgagcggcag caccgaggta
      181 cccgccgcgt cgagggccag ccggttggct gcccacccct cgcccgcgag gccggcgacc
      241 ttgtcggccg cgtcctcctg gaccagcgcg agcaccgtgg ggcccgcgcc ggagatgacc
      301 gcggggacgc cgtccgcccg cagtcggttc accagggcca cgctcccggg catcgcggga
      361 gcacggtact cctggtgaag tcggtcctcg gtcgcggcca gcagcagctc ggggcgcctg
      421 gtcagggcct cgacgagcag tgcggcgcgg ccggcgttgg ccgcggcgtc cacgtgcggg
      481 acggtccgcg gcagcaggcc ccgcgcggtc tcggtgagca ccggcttgcc cggtacgaag
      541 accaccggaa cgatggaatc ggcgggatcc agccggatcg cgcgcgccga tccggtatcg
      601 gtccaggcca gggtgaagcc gccgagcaga caggcggcga cgttgtccgg atggccctcg
      661 atctcggtgg ccagttccag cagtgccgcg tcgtccagct tctgttcggc gcctatggtc
      721 accgcgcggg cggccatgat gccggcacag atcgcggcgg aggaggagcc catgccgcgg
      781 ccgtgcggga tgcggttggc gcacacgatc tccaggccgc gcggctgccc gccgagcagg
      841 tcgaaggcgg cgcgcaggga ccgtacgagc aggtggctct cgtcgcgcgg cagggtctcg
      901 gcgccctcgc ccgcgatgtc gacgtgcagg ccggaatcgg ccacccgcac cacgacgtcg
      961 tcgtacaggc ccagggacag cccgaaggcg tcgaagccgg gaccgagatt ggcgctggtc
     1021 gcgggggtgc gcacccggac ggcggcggcg cggaacgctg gaccggccat cgctcgatga
     1081 ctctccttga tgtgatgctg cggcactgcc ccggagcgcc gcggcaccag ggtgcccggc
     1141 cggctcatgg ggaccgttct gacctgccct gcacaccact gcgacatgcc gtggggaggg
     1201 gagttggctg ccagcctatc gaaggaaggt tctgtggcga catagggcgc acaggaggcg
     1261 cacgatgcgt gtcgcgcgct gcccgcggct ctcggccgcc tttgcagcct ttgcagggtt
     1321 tgctccatcc gaggttacgg ggttcctgcg gtcccggtaa cccctatttc gggggatgtc
     1381 gcgcgccggt gcgggcggtg cgcccggccg ttccgcacgg ccgggcgcac ctcccttccg
     1441 gaaggcgggt tacgccaggc cgaggcgctc ggccgcggcg tccgcgtcga ccgggacggt
     1501 gaccggctgc ggggcgcccg cgacggccca gtccgggtcc ttcaggccgt tgccggtgac
     1561 cgtgcagacg atgcgctggc ccgggtcgac cttgccctcg tcggccgcct tgagcagtcc
     1621 ggccaccgag gcggccgagg cgggctccac gaagacgccc tcctgggagg ccagcagccg
     1681 gtaggcggcc aggatctgac ggtccgtcac ctcgtcgatg gcgccgccgg actcgtcccg
     1741 ggcacgctcc gcgaactgcc aggaggcggg gttgccgata cggatggccg tcgcgatcgt
     1801 gtgcggatcc ttgacaactt cgccacgtac gatcggcgcg ctgccggacg cctggaagcc
     1861 ccacatgcgc ggggtgcgcg aggcgaggcc gtcggccgcg tactcctggt accccttcca
     1921 gtacgcggtg atgttgcccg cgttgccgac cggcagcaca tggatgtccg gcgcgtcgtc
     1981 cagcatgtcg acgatctcga aggcggcggt cttctgcccc tcgatccgta ccgggttgac
     2041 ggagttcaca agtgcgacgg ggtacttctc ggagaggccg cgggccagcg tcagacagtc
     2101 gtcgaaattc ccgtcgacct ggaggatctt cgcgccgtgc accagcgcct ggcccatctt
     2161 gcccagcgcg atcttgccct gcgggacgag gacggcgcag accatcccgg cccgtacggc
     2221 gtaggcggcg gccgaggccg aggtgttgcc ggtggaggcg cagatgaccg ccttggcgcc
     2281 ctcctccttg gcccgggtga tggccatcgt catcccccgg tccttgaagg agccggtggg
     2341 gttggcgccc tctaccttga gatgcacctc acagcccgtg cgctcggaga gcacctgggc
     2401 gggcaccagc ggcgtaccgc cctcgcgcag cgtgacgacc tcggtcgacg cgccgaccgg
     2461 cagccggtcg cggtactcct cgatgattcc gcgccactga cggctcgcgg tggaaatggc
     2521 agacatgggt tcctttactc cccttcgacc cgcatgatgc tggcgacgcc ccggaccgtg
     2581 tccaggtcgc gcagcgcgcc gacggtcgac gacagggcgg cgtcggccgc ccggtgcgtg
     2641 acgacgacga gggacgcctc tcccccgttc tcggcttcac cggagcgggc ggcacccccg
     2701 tccttgctct gctggcggac cgtgtcgatg gacacaccgt gttcggcgaa gaccatggcg
     2761 acctgggcga ggacaccggg cttgtcggcc acgtccaggc tgatgtggta gcgggtgacg
     2821 acgtcaccca tggggccgac cggcagctgt gtgtaggccg actcgccggg gccggtggtt
     2881 ccggccagct tgttgcggca gaccgccacc aggtcgccga ggaccgcgga ggcggtcggc
     2941 gagccgccgg cgccggggcc gtagaacatc agctggccgg cggcctcgga ctcgacgaag
     3001 accgcgttgt acgcctcgcg cacggaggcc agcgggtgcg tcagcggaat catcgcgggg
     3061 tgcacgcgcg cggtgaccga agcgccgtcg gccgcccgct cgcagatcgc gagcagcttg
     3121 accgtgcagc ccatgcgctt ggcggaggcg atgtcggagg cggtgacctc ggtcagcccc
     3181 tcgcggtgca cgtcgtcgat ggtcacccgg gtgtggaagg cgattccggc caggatcgcg
     3241 gccttggcgg cggcgtcgaa gccctccacg tccgcggtcg ggtcggcctc cgcgtacccc
     3301 agggccgtcg cctcgtccag cgcctcggag tagcccgccc cggtgctgtc catcttgtcc
     3361 aggatgaagt tcgtcgtgcc gttgacgatg ccgagcaccc ggttgacctt gtcaccggcc
     3421 agcgactcgc gcagcggccg gaccagcggg atcgcgccgg ccacggcggc ctcgtagtac
     3481 aggtcggcgc cgttggcctc ggcggcggcg tgcagcgcgg caccgtccgc cgccacgagc
     3541 gccttgttgg ccgaaacgac gctcgcgccg tgctcgaacg cggtggtgat cagcgtacgg
     3601 gcgggctcga tgccgccgat gacctcgacg accacgtcga cgtcatcgcg tttgaccagc
     3661 tccgtggcgt cggtggtgat cagctcggcg ggcacccccg cgcgcacccg gtccgggcgg
     3721 cgtacggcga ttccggccag ctcgaccggc gcgccgatgc gggccgtgag gtcgtcggcg
     3781 tgcgtcgtca tgatgcgcgc cacctctgag ccgaccactc cacagcccag cagcgccacc
     3841 ttcagcggac gcgtacgcat cattcgacct ctttcgcttt ccttctcggt ctgcaccagt
     3901 ctcacgcacc ggaccgggaa ttccggcccc ggtccggatg ccgagacatc tgttccacca
     3961 ttgtcggtca cccggcgggt tcccctgtca ccggccgccc gcgcggggcc ggcccggtcc
     4021 tccggccctg cggtcccgct gagccctgcg gtgctgcgcc cgtcgtcacc cgacgtcgag
     4081 acgcagcagg tcctcctccg tctcgcgccg gacgatgacc cggcccgctc ccgcgcgcac
     4141 cgcgaccacc ggcgggcgca gcgcgtggtt gtagttgctc gccatcgacc ggcagtacgc
     4201 gccggtcgcg ggcacggcga gcaggtcacc gggggccacg tcggcgggca ggaacgcgtc
     4261 ccgcacgacg atgtcgccgc tctcgcagtg cttgccgacc acccgcgaga gcatcggcgg
     4321 ggcgtccgag gcccgcgaga ccagcgccac gctgtactcg gcgtcgtaca gcgccgtacg
     4381 gatgttgtcc gacataccgc cgtcgacgga gacgtacgta cgcaggccgt ccagctcctt
     4441 gaccgtgccg acctcgtaaa gggtaaaggc ggtcggcccg acgatggcgc ggcccggctc
     4501 cacggacagg cgcggcacgg ccagccccgc cgccgcgcac tcccgggtca cgatgtcgcc
     4561 cagcgccttg gcgatctcgt gcggctcgcg cgggtcgtcg tcggaggtgt acgcgatgcc
     4621 gagcccgccg ccgaggtcga tctccggcag ctcgacgccg tgctcgtcac gtacctcggt
     4681 gagcagctgc accacgcgcc gcgcggacac ctcgaagccc gccatgtcga agatctgcga
     4741 accgatgtgc gagtggattc cggtcagctc caggccgtcc agcttcagca cccgccgcac
     4801 ggcctcggcg gcctgcccgc cggccagcgc gatgccgaac ttctggtcct cgtgcgcggt
     4861 ggcgatgaac tcgtgcgtat gggcctccac gcccaccgtc acccggatct gcacccgctg
     4921 ccgcttgccc agccggtccg cgatgtgcgc cacccgcacg atctcctgga aggagtccag
     4981 gacgatccgc ccgacgcccg cctcgacggc ccgggtgatc tcctcggtgc tcttgttgtt
     5041 gccgtgcagc gcgatccgct cggccggcat ccccgccgcg agcgcggtgg ccagctcgcc
     5101 cccgctgcac acgtccaggt tcaggccctc ctccgccagc cagcgcacga ccgcccgcga
     5161 caggaaggcc ttgcccgcgt agaagacgtc cgcctcctcg ccgaacgcct ccttccaggc
     5221 ccggcaccgg ctccggaagt cgtcctcgtc caggaagtac gcgggcgtcc cgaactcttc
     5281 ggcgagcgcg gacacatcga tcccgccgac ggtgaccacc ccgtcggcgt tgcgctcgac
     5341 cgtacgggcc cacacccgcg ggtcgaggct gttcagatcg gcgggcggcg cggcgtagtg
     5401 cccctcgggc agcacgtcac cgtgacgggg gcctgcgggg tgggcggagc ggctcatggc
     5461 gtggaggttc ccctcgggta cgggtacggc gtcgccgtgc acagggcgcc gccggatgga
     5521 tcacagacgt tcgggcgtgg agatgccgag caggtgcagg ccgttggcga gcaccgttcc
     5581 ggcggcttcg gcgagtgcca gccgggcgcg gtgcacggcc gagggtttct cctccccgac
     5641 cggcagcggc ggacacacgt catgacatcg cagccaggcg tcggcggtca cttccagatg
     5701 ccgggcgacc cggtcgggcg cccggtgccg cgcggcggcc tcgaccacac cgggatactc
     5761 ggcgaccgcg gcccagacct cccggaccgc acgcccgtcc cccatgtccc ccggttccgc
     5821 cgcgaacccc aggtcccggg cattgcgcgt catcgcacac gtacgcgcat acgcgtactg
     5881 cacccggaac cgcccgttgc tctcccgctg cacgggccgc tcgggcagcc gcacggcatc
     5941 ctgctgagcc acccggagca gaacccagcg ggcctcgtcg gggcccaggc gggcggtcag
     6001 ggtgcgccag tcttgatggg gggagtgggg gtgggattcc accgggtggg gggcgacctc
     6061 ctcggtacgg ccccgggcca ccgccgagtg cggagagctc ccctctcccc tcggctcggc
     6121 ctttgccgtg attccccccg cgggcagaat ccgctccaac gcctccgcca cgaccgcagc
     6181 ccgcaccccg gccgcagccc gcagccccac cggcccgcag ccccgccccg gttcctgccc
     6241 gtcgccgcgc ccggcggtgt ttccgtactc ccgcccctgc gccagcacac tccatacgag
     6301 cccggcgcgg gcggcgcccg tcaacgtcac attcaggaaa ccggccccgg cgatctccac
     6361 accggcgatc ccggacacac ccgccaaccg ctcacgcagc atcgcggcca cctcacgcga
     6421 agggcggccg gcctccttgg cgacctgcaa cgcgacactg cacgccagat cggccgctcc
     6481 gccgcccccg cctcgcgcgg gcacccgcac gacaacccgc tccggaacgg tcacggagag
     6541 ttctccgtcc tccacagcgc cgcgcacgga gcgcaggacg gcgcgggaga gctcagcggg
     6601 ggtcacgccc ccagcgtatg ggaggaacgg tccctcaccg ccaccaggtt tcacccatcg
     6661 gacaccccgg cggccgctca ccctccgcca cggcccggcc cctcaccccg caggacggac
     6721 gacggactcc gcatcccctt cggcgtcggc atcggcgtcc gcatcggcca gcccctcgcc
     6781 gcccggctcc ccgccacggc tcatcagccg ccgcaccata cgcacaagat ccatgggctc
     6841 gaacggcttc gccaggaacg cgtccacccc cagcgcctga ccgctctcca cctccacgtg
     6901 ggtgcaggcg gagacgacgg cgagaggaat cccccgcgtc cgcggatcgg cccggagccg
     6961 ggccgccgtc tgcagcccgt cgagccgggg catcaccaca tcgagcgtca ccacgtccgg
     7021 cgcgacccga tgcacgatgt ccaggcactc ggcaccatcg gccgcggtca cgacctcgaa
     7081 gccctcaagc tcgaggttga ccctgatcaa ctgccggatg accttgttgt cgtcgaccac
     7141 aaggacccgg ccggacaagc caggcacacc ttgagactag gcgcgcgcct ccggctgcgt
     7201 ccgggttttc cccacttccg ccccgtgcga gggacctttc cccgaccccc ctgcccccca
     7261 cccccacatg cgctacaccc ccctcctcca acccgttcat gaacaccccg tcagagctgg
     7321 tagtgttcta cccgtcgccg cgagagcagc cgacacgccc ccgtagctca ggggatagag
     7381 caacggcctc cggagccgtg tgcgcaggtt cgaatcctgc cgggggcacc gcagttcagg
     7441 tgcctagaag gccccttgat caggcgttac gtcaggtcaa ggggcctgca gctatctgca
     7501 gccaagtgcc agcgaatgca cccgtaggac aacccttgcg ggacatacgc gggatcggac
     7561 attgaccgac cattgggact agtcggcaca acagaagcac cccgaggtgt tcacctcggg
     7621 gtgcttagtg tgatgatcgt cacgcgtatt cgagcaacaa cttctcgatc cgctggttcg
     7681 cgacgaggtg cctgccgtgg aggcacttgg cgtagcgggc gagcaaaacc tcgaccgtgt
     7741 ttcctgcccg ctccgcaact tcggtcgggt ccacaccggc gttgagccat gttgagagcg
     7801 ccgaatggcg gaggtcgtac gggcagtcgg ccagaggact gttcacgagg tccggtggga
     7861 gcgcgaactc cctggcctcg ccccacacgc gtgagtaggt cgaagatccg accagtccgc
     7921 cacgctcatt gaagaacagc cgaccgtcgt ctgcagtacc gaaggtgtcg atactgtccc
     7981 gccacatggc caccaggacg ggaggcagtg gagtaggccg gacctccccc tgagcccgat
     8041 tcttcagccc gcggtcgtcg tgcacctcac cgctcttcgt ccacttcttc cccgccgtgg
     8101 gccgcgttcg gtgcaggttc gccagccccc acccctccgc cggcaggtgg caatcctgaa
     8161 tggcgacgcc aaccgcttcc gccggccgca tccccgcgta gtacatgccg ccgaacattc
     8221 cgacgaggcg acgccctcgg gcccggttat agccgcccac atacgagaca gctcccagca
     8281 gattggacgc ctgctgcgga ttcgcgacca cgcgagggtc gacgggaatg actctgggtg
     8341 gcctcttaac ggaaacggcg tgaacggggt tctcctcgaa ctctcccagt tcggtcgcgt
     8401 aattgagcgc gttaacgagc accttacgct tccgcttgaa cgtttcgctg cccgcagcct
     8461 ccccgttgag tttgagcttg agagcctcaa gcactccccg catcacggcg ggcttattca
     8521 gatcggcgag cggtggcgaa tgcttcacca gccagtcgat cacagacctg gcctcgggcg
     8581 ggatgctgcg ctcgtccggg ccgggcagca cgaatgccca gtcgcgcagc gccctctgca
     8641 tggccgcatc cgacggccga ccggcatgca ttggggcgag cgccttggtg accccgctca
     8701 gcgcctcatt gatctcatcg cggtaatttg gcgcagagtg cggccacttc atgcgcaggt
     8761 acttcaacgc gaaggcatac caggtaagaa gaggcccctg ttcctccatt gaaggaggaa
     8821 gaccagagac ggtatcgaac tgctccccgt tgtcctgcgc catgaggagc tgagcacgca
     8881 gcttgtcagc gagtccttta gtacggcgcg accgcgagat ctcgcgcccc gctaccgtcc
     8941 aacggacctc gtaggtatcc cttccttgcc gggacttcgg cctgacgccc catattcgaa
     9001 cgtcggtcgt cttcaagctg ccgcttcctc tctctcctcc agccaacgcg taagagcact
     9061 tcgccatacg cgcagctcgc cattcgggag cttgagaaca gtgggaccgg ttcccagctc
     9121 ccgccatcgg tagaaggtcc ggcgagaaac accattcagt tccgccagca cttccggcac
     9181 cgtcataagc ctgtcattct tgtctgccct ctgcacgagt tacgcaccag aaggcatggc
     9241 acacgcacac cagccgctaa ggtgcggatc agtcacgaac acacccgtcc ggcgcgcgcg
     9301 actaattcgg gctttgtgtg gcatatgcgg gttccttgca gagtgactgt cgccgcacga
     9361 cggagccgtc tggcgcttac cgttcacgcc atgtgcgggc taggtatacg tgtccgggcc
     9421 tcactgaagg agacgccgca cacagaccta tccgcaccga agccaccgcc aagtgtcggc
     9481 gcgaacagca tcaatactcc gcacgatcgc cggtttggct aaccggcgat cgtcggctat
     9541 gttgcgttcc tcccgttccg gaacgcatcc tctttctctg tcagtcagta cgcgttcgag
     9601 cacccgagcg ggctgagaca gtcacccgaa caaaccggag agcgcgggtc gacagaacag
     9661 actcctcaca tgtcgcccgg cgagctgctg gcaagccctg tatctccggg ggtgttgtac
     9721 gttcgcttag cgccgggaga agttccagtc ctttgcggtt cttcctcgtc tgccgtgagc
     9781 gaaggccgga tgacggctca ctcgatgcgg ccgggaagcg agaatgtagg acgccggagc
     9841 cccaactgtc gcgttgtcgt cagccgtcac cccatcgtgg gggcggacca ccacagcgac
     9901 gtcgcacgac caccgtcgaa gacgaggtgt ggctgcggca gcatgtcgcc cgggcggcat
     9961 cgtggcagga ggtgggcggc tgtgtgaggg cgcccacccc gtgctcaccg atgagggcgg
    10021 cgcgatcctc ggcgagcgga ccggccgctg ggcctacctg acgccgaccg cgtcggccac
    10081 ggtgatgctg ctgctcgcct cgaccagcca ggaggaggcc gccggccagt acgccgagcg
    10141 gtacggcacc ggcgtgcagc aggccgccgc cgacgtccgt acggtcgccg atacgctggc
    10201 cgcgcggggc cttgcccaca ccggccagga accggtccgg acgcaccgcc gctggtgggg
    10261 gtggcggccg tgaccagtgt ggaggcgtac tccaccgtcc gcaccggcac cctgcccgag
    10321 cgcctggccg ccacagccgg gctcacactc gccctggttc tgctgcggct gccgttccgg
    10381 tacaccgccc gcgcccggca ccgcggacgc ctgcccgggc tcgccgcgct gcccactgcg
    10441 gcgggtcgcc ccccgccccg ttcgtcctgt ccatccgtcc tcccgtgtgg ggcttcagtg
    10501 ccactgccga cggtagcgaa gccgcgccga cccacacacc gcacacggaa gctggccagc
    10561 gatgcagctc caaggcgggc ggggcgccgg catacggctc cgaaaagcga tcggtcctcg
    10621 tgtccgggcc gcacccttgt cccgttcagc gcgcggtggt gaccgcgtct tccaggcgct
    10681 cgcgcagggc gctgatgtcg ctgctgctcg cgtgtggctc ggtttcctcg tggagttcgc
    10741 tgagccggtc ggcgatacgg gtactgtgca ggccctcggc gatggtgagg gcggtggcgg
    10801 cctcctggca ggctccggcc agttctccga cggccaggtg ggtacgagcg aggccgatgt
    10861 ggtcgaacgc tcggctgcgt acgcggccgg cgggccgcag ccgcagggcg tttgtcagca
    10921 gggtcagaga ctgctcggcg cggtgggtgc gctggtgacc ggaggtctgc ttggcggcga
    10981 tctggtgggc gatgccgagg gtggccgaca gttccgcctc gtcgaagaag gcggtgtgcg
    11041 gcggctcgtc accggggcgg atgcgggtga aggcgtcctc ggcctcctgg gccgcccgct
    11101 ggctctcctc cagatcgccg cacatggcgc tgaagcggga gtgcagcgca gcgaggaccg
    11161 cgcgggtgcc ggggctggcg tgccggcgtg ctccgtactg ggccagggcg atgagttcga
    11221 gggcgtcctc gacgtgcccc aggtgggaca tctggcgggc catgcactgg aggatgtgcg
    11281 cgccgagctg ccggtctccg ccttcgctgg cggcgtgcac tgcggtgacg aagagccgct
    11341 gtgcgctgac gtgtgctccg gcgtcgaagg acatccatcc ggcgacactg cccaggtcgg
    11401 cgacggcccg gaagaggcgg cgcccggtgg cttcggtgta ggaggcggtg gcgagcaggt
    11461 cgttgatctc gctcatctgt gccacgacgg cccggcggga gagcaccccg ccgtgccggt
    11521 tgtccgcgtc ccggaaggcg gcggtcagcg cctcgatcga tgcgatctgc gcggtgccca
    11581 gcgtgccggt gcgcggcgca ttcggcaggg cggcgggttt cgcggacggc cagcgccgaa
    11641 gcggctccag gagggcgtcg gcggcctgga tctgtgtggc gtcgtggctg gtgcgggtgt
    11701 gcggcagcat caggtcactc cgggtcaggt gagcgatggc ggcgatggtg gcggtgtgct
    11761 gccacggcag gtcggtgccg aggccggtcg gcggtagcgg tcccggcagc cccacgtccg
    11821 ccggggtgag cggcagggcc agacgggcac cgagcacctg ggcgatgagc tgcggcacgg
    11881 gctggcgcgg gcactccccg ccgcgccagc gccgtacccg gctctcgtcc ggattgatgt
    11941 cccggtgccc tgtggctcgc gcccccgcgg tcaccgcctg tgcgagctgg gcgttggtga
    12001 gctgggcccg ttccatgaag tggctcaaga gtgtgttggg caagttcccg gccatcctcg
    12061 ggcccttccg tggggttacc gccgaacctt ccgagcgtaa ggggtgcggc ccccagcagg
    12121 aacaacgccg gttcattcgc cggtccttcg ccgattctct cgccggggcg gcgccgcggc
    12181 atcagcctgc gttcgccgcg cttcaccggc ttcgcccggc caggtggctg tggtgccgtg
    12241 gtgatgatgc cccggagccg cggccccgga gcctggcgta cggatcacag cgagaggccc
    12301 cccatggaac ttccgttcat cgtggtcgat cagctcaccc cgcagcagga acgcgactgg
    12361 cacgcctact tcggcacccc cggcgccgac cggccccgcg acatcgaaga aggcatctgg
    12421 cggcgcaccc aggagtcggc cacagccccg caatccggct ggcagcccgg cgacgcacgg
    12481 cgccgcatgg tgcactaccg ctaccgctac ggcctcgcca ccaccaccgg cgccccggcc
    12541 ctggcactgc ggcagctgta cctgtaccac cacgccgccg ccccggccga ggagatcggc
    12601 gcgcactggg aggcggtccg tgccgccctg cgcgaaggcg gctggaagcc tgaaggcggc
    12661 gcgtgggtgc gcggcgatct gcacgtcacc ccgaccctgc actctgcccc gcaccccgaa
    12721 gacctgcgcg ccggccgcac cctgccgcac ggatacgcct gtctggacgt acaggtcacc
    12781 tcgtccgggt acgtgccgcc cccggcgacc cgccgtcgtc cctgggacgt cctggccagc
    12841 ggcgtccgcc ggaaagcggc ccccggcacc ttccggcgca tcccggacct cgccccgctc
    12901 gccgactacc tgcccttcca ggtggaaatc ggctgcggca ccagctggga ggccggcatc
    12961 cccgcgctgc accggctgca cgaggtctac cgggtcacca cccgcgagga cgacgccccc
    13021 ggcacccggg acttcgtgct gcgcccccag aatgacccgc tgctgcgcga aatcctcacc
    13081 gcgccggaag agaaggtcga ggaatgcgtg gagctgtacc gcgcgtgctt cctggcccgc
    13141 cccactccgg cgctgtacgc gctcaaggag ctgcacgacg cggggctgat ggcgggcccg
    13201 gtgatcacga acaatttcga tgtgctgccc gcccgcgtcg gactgcgcga gtgcttcatg
    13261 cgccgctacg accagaccgt ccccgacgtg gagttcgtgg acggcgccaa ggcgctgctg
    13321 gtggtcggcc tgcacgccga ccggcgccag gtcgccgccc gcgcccgcga gcggggtatg
    13381 caggtggtcc actgcgatcc cgagggcttc tggcacgacg gggtcttcca cccctacccc
    13441 ctggagggtc cgcaggacgg cgacctggtg tgcaccgcac cggcaggtga ggcactgccc
    13501 gacctcgccc agcacctgct ggagaagatc gcggcctgag gtcacgtcaa cggcgcgacc
    13561 tgcggaatgt ccgcccggcc ggtcaacggc gctagcgtgc gagcccgttg accggcccgg
    13621 ccccgcaccg gggccggacg gactttcgaa ggagcacccc gaatgcgcgt atccgtcatc
    13681 ggctgcggcc acctgggcat cccgcacgcc gcaggcatgg cagagatcgg ccacgaggtg
    13741 atcggcgtgg acaccgacca ggcaaagatc gacaccctca accgcggcga aagccccatc
    13801 tacgaggcgg agctgcccga actgctcacg cggcacaccg ccagcggacg gctgcgcttc
    13861 accaccagcc tcgccgaggc cgctcaggcc gccgacgtgc acttcctcgc cgtcggcacg
    13921 cccatcgacg cggacggccg cggctacgac atgggccagg tcttcggcgc cgcccgtgct
    13981 ctcgccccgc acctgacccg gcccacggtc atcatcggca agtcgaccgt cacccccggc
    14041 accaccgcca agctcgccgg cctgctggcc cggcacgcgc ccgccggccg cgacgtcgag
    14101 gtggtgtgga acccggagtt cctgcgcgag ggccacgcgg tcgccgacac cctgcgcccc
    14161 gaccggatcg tcgccggtgt cccctcccac cgcgccgagg acgtcatccg cgaactctac
    14221 gcacccatcg acgcgccgct ggtggtgtgc gacccgccca ccgccgaaat gatcaaaggg
    14281 gcggccaaca ccttcctcgg cctgaagatc tccttcatca acgccgtggc cgacatgtgc
    14341 gccgcctccg gcgcggacgt ggccaccgtc gccgccacca tcggcatgga cccgcgcatc
    14401 ggggtcggcg gtatgagccc cggcatcggc tacggcggcg gctgcctgcc caaggatatc
    14461 cgcgccttca ccgccgcggc ccgccagctc ggcgccgatg atgccgccgg cctgctgcgc
    14521 gccgccgaga tcatcaacga gcaccgcccc gccgcagccc tcgacctgat cgcccaggcc
    14581 ctcgacgggc gtctggccgg ccgtgacgtc accgtctggg gtgccgcctt caagcccggc
    14641 accaacgacg tccgagaatc ccccgccctg gccgtcgccc ggctgctcca ggaccgcggc
    14701 gcccgcatca ccgtgcacga cccgcatgcc gtccccaccg ccctggcccg ccaccctgag
    14761 ctggagtaca ccaacgatct cgccgcctcc gtcaagggcg ccgacgccgt cgtcctggcg
    14821 accgagtggc cccactaccg cgacgccgac ccggccgcac tgcgcgacct gcccgccgaa
    14881 cccttgatcg tcgacctgcg caccgccctc gacccccacc gctggacggc cgccggctgg
    14941 tgcgtacacc agctcggccg ccccgcggtg cgcacacccc actagatcgc cgggcaccgg
    15001 acggccgccc gccttcccga aggagtctca tgaccacgca caagctcctg gacgtcctcg
    15061 acctcgacac catcgaacgt ctcgcggccg tgtgccggca ggcaggcagc gacctgcccg
    15121 acggggagct gaaggccctc caggtcggca aggtcggcga agaaggcggc gaggccatgc
    15181 accagctgca cggcctcaaa gggctcacca cctgcgactg caagcagcac tcctgggacg
    15241 gcgtgatgaa cgacctcggc ggcgccgttc tcgcctcgct catcgccatg gtctacatcg
    15301 aacccgacag ctggcgcacc accctgacag aggtcctgca ccgccgcacc cggcgcggcc
    15361 gagaacacac cgccaccgca taacaccgcg acacctgggg cgtggcagcc gcattgccgg
    15421 gcgcccgcgc cccaggcgcc taccgtggac ccaccggcga gccaaggagt gcccatgggt
    15481 gtggcggcag cgatccgcaa cagcgacggc gcctacctgc tgcacctgcg cgacgacatc
    15541 cccggcatct gctggcccgg ccactggagc ttcctcggcg gccagatgga ggccgacgag
    15601 acccctcacg aggccatcac gcgcgagctt caggaagaag ccggcctcaa cctccccgac
    15661 ctgcattctc tggccacggt gcaacagggc aacggccgac ccgacatcga ggtcttcacc
    15721 gcctcctgga acggagacgc cacccgcatc gaggtgaccg agggcatcat gctcgcctgg
    15781 ttccaccccc ggatactgcc gcgtctgcgc gtcccaccct ggtgcgtcga agccatccac
    15841 ctccaccacg ccaccccaca gcagacaaac ccacccgttc ctccatgaac caggcagacg
    15901 gcggtccgac cggcgttgcc tccgtggtcg tcgcccagga cgcagcaggc cgcgtcgccc
    15961 tgctcggcgc ccgccgcagg ggcggcgagg ccccgaggct ggcgcccacc accgcttcga
    16021 gacggacccc gaggtgcccg catgcgaggt ggcgctctac cggagtgcca cctccaccct
    16081 cgaacgcctg ggcgtacagg tcctcaccat cgacaccaac gtcctcaccc ccaggaggca
    16141 gccgcccgga tcgccagcgc cctagccccg ccagccgcta gcgtcgagac gaccacaacg
    16201 gccccgacga gcacggtgac cccatgccca cagcaacccc cgtcatcgac acccacgtga
    16261 tcctgcgcga cggcgacaag atcctcctgt cccaacgcgg cagcccctac ggctacggcc
    16321 gctggcacct gccctcgggc aagctcgaca ccggcgaatc cctccccgtc ggcgcagccc
    16381 gcgaggcgca cgagggaacc ggcatcaccg tcgacccggc ccacctgcgg cacgtccaca
    16441 ccgtccacca ccagcagagt cccggcgacg agcgcatcgg cttcttcttc ctggcaaccc
    16501 gatgggaggg cgaacccacc aaccgcgaac ccgacaagtg cctcgacctg cgcttcttcg
    16561 acgtacacga cctgcccgaa gacatcatcg aataccccgc cgccggcctg tacggctacc
    16621 tgacgaaccc cactccactc accctgcacg gctggccgca gcactgaacc acacagacga
    16681 cgggccgact cgcgatgcct gcgtagtagc cgtccagaac ccggcaggct gcgcccctgc
    16741 tgagcgccaa ctcccccggc acggcgctgg atacctcttc ctgtcctccg ggcaccgcgg
    16801 ggacgcggcg agccccgagg cgtgcgcccg ccgagagcta caggcagaag ccgcagccgg
    16861 cctgcacctg attgtcaccc ctttcttcga cgagctggcc ttcggaagtt ggcgagcctg
    16921 accgtcggtc gggcacgatc cgtccatgag gattctcgtt atgggcggca cgtggtttct
    16981 gggccgggca gttgtcgagg aggcgttgcg gcgcggttgg gaagtgagca cattcaaccg
    17041 cgggcgttcg gggcaggacg tgccgggcgt acggccggta cgcggggatc gcaccgcggc
    17101 agaggacttg gccgagctgg cctcgcacgg cccttgggac gcggtggtgg acacgtcgtc
    17161 ggcggcactg cctcccaaag acgtgctgac cggggcgcgg gcactgaagg cggcggcgga
    17221 gcggtacgtg tacgtgtcga ccgtcaatgc ctaccggggc tggcccggtg atccgctgac
    17281 tgaggcgtcg gagctgctgg acggaccgcc cgacgcagat gcagattacg gccgcttgcc
    17341 ggaggactgg accggccctg actggtacta cgggcggcag aaagcggggg ccgagcgcgc
    17401 ggtgctggag gcgttcggcg agaagtgttc ggtgctgctg cggcccggcg tcatcctggg
    17461 gccaggagag tatgtggggc gcctgccgtg gtggctgcgc cgggccgagc ggggcggccg
    17521 tgtccttgcg cccggcctgc caggcaagtc gatccagccg gtggacgtgc gggatgtcgc
    17581 cgtattcgcc ctggatcaag ccgcggcgcc ggtgggcggg gcgtacaacg tcgtcgcccc
    17641 gatcggccgg gagacgatgg gcggcttcct caacgcgtgt ctggaggtga cgggccaccg
    17701 gggcgagctg tcgtgggtgc cggatgcctt cctcgtcaag gccggtgtcg agcagtggac
    17761 ggagctgccg ctttggcgta cgcacgcggg ggtgtggaac atcgcctccg acggggcgca
    17821 ggcggccggt ctggtgtgcc ggccgctggc tgagacggtc gaggcgacgt ggcggtggct
    17881 gcgtgacggc ggtctgccgg tggcccaccc gcgggcggac gagcacggta tcgcggcgcg
    17941 gaaggaagag cgtcttcttg aggagttcgc cgagcgcgtc gcgtcagggt tcgagggcga
    18001 gaggctctga tccgcggaag ttgcgggaga cggagctggc ggagaattcc tcgatgcgct
    18061 cgccgagttc ggtggccttg gcggcagtgc ggaacaccgg gcgggtgagc tgggcgcggg
    18121 ctgcggccag gcgttccaga acgcctgcgc cgcgccagtc gcggggcaca tcgaagaccg
    18181 gggccagagc gtcacaggcg ccgtcgagtt cttggcgcag gaggcgggcg cgggccaggt
    18241 cggtggcggc ctgtgaggag atgagcagcg gtcgggagcc ggcgtcacgc tgatcgagga
    18301 ggtgcagggc ctgggtggcg gcttcttcgg ctccggtggc gtcgccgatg agcaggtagg
    18361 tggtggcgtt gctcatggcc aggcgttcgg agctgaagcc gaattctccg ccgatgtcgt
    18421 cgtgcaggtc gtcgcggttg ctgtggggga tgtcgaggga gtcgcgtatg gcctggacgg
    18481 cttgttcgtg atcgccgagg tgggcgtggg tgcgggcttc gatgacggcg aggcgggagc
    18541 aagcggtggc gcccagccct ccgaagcctt gggcagtacg taccagggtg agggcggcgg
    18601 cggggcgtcc actccagtag gcgaggaagg cgagggctcc gtgggcgtac gcctggagcg
    18661 gcccgtgttc gatgacctgt ccgtagagga tcgctgtccg ggagtgctgg acggccggct
    18721 gcagggcgcc gaggtcgaag cagacagcgg agagcatggc cgcggcctgg ccggcggtga
    18781 ggtagaggtg ttcacgctgg cgggggacct gggtgcggtc gagcttttcc tgggtgtcga
    18841 ggaggagttc cttggccgtg cggtatacct cgggcggaga ggtgctgttg taggtgcggg
    18901 cgatatcgag gatggtgtcg cgcagccggt cgagggttat gtcgggcacc gtgagggagg
    18961 cggcgtcctc cgcgtgggcg gcagcgtcgc gagcagtcat ggtcagttcg ctttcgtcga
    19021 tcgcgggtaa agcccgcgtg gtgtcgtccg gggcgggctg gaataaggcg tgtgccgggc
    19081 acccgtacat gtgctccaag atccacggag cgggttgctg cggcagcgtt tggacctttc
    19141 ccgacgtcca gcgtcggaag gtgatttccg agacggtcgc cgtagcgatg ctgcggtcgc
    19201 ctcgcgtgtc ggcgaccttc cgtgcggcct tttggtagtc ctgcacgaag gtcccgtagg
    19261 tctggtgggc ctcatccacc agacgcttga gcaaagtcgg ggcgggttga ggggccacgc
    19321 aagctccttt caacgtcgac gggctctgag gtgcaggccc gccgcctccg tcacttttcc
    19381 ctactgcggc gtacgcgcaa ccgttttgcg cgtggtgata cccgagtgac acgcccgtgt
    19441 cactacggcc cgctggcgat cggcgaagtg acacctccgc gagatggcgg tgtcgcctcc
    19501 ctggcgagat tctgtctacc cgctctccga tcttcagcgg cgggcggctg gcgtgcaccg
    19561 accaccgacc tgtgcctgcg agcgctcggc ctgacccact tcgccgtgcc cgcgggcctc
    19621 gtcctactcg tgatccgtaa gcacctgacc ttggagacca ccgatggcac ccccttcgtc
    19681 cgcactcgcg ccggtctctc cgctgccgtt cgccccggag cagcagggcc gttacttcct
    19741 cggtgccggc aacccggcgc gcctggctcc ggatcatccc gccgacatgg tgctcggtac
    19801 gtcacacctg gtcgacaccg tgctgagcga gcaaaacccg ctgccggagg gcgaacaggt
    19861 cacgtacctg accgcgcggc tgcacgagta cctgccgcat ctcgctcagg tactggccga
    19921 cgcgcctact ccgggcgcgg gcccggcaac acaccaacgg ctgcgagcca tcgaccgggc
    19981 ccgcgctcag gcaggtgccg agatcgtcgc cgatccgctc ggggttcgca tccaactggt
    20041 acgcctggcc caggttggtc aggaggtact gtcccttctg ctcggcgacg gtgacgtgga
    20101 cggcgcaccc gccgggtttt cctcgcgcct ggtccacgag agcgtgaaag tcacacgtga
    20161 gtggcgcatt cctgggacct acccccaccc ggaatcgctc gtcatggtca ccgccgccct
    20221 gacggactcg atccgcggca tgtgttcctg catcacaggg ctgctgtctc atc
//
