LOCUS       NZ_MPOH02000011        10522 bp    DNA     linear   CON 03-MAY-2024
DEFINITION  Streptomyces phaeoluteigriseus strain DSM 41896 Scaffold_11, whole
            genome shotgun sequence.
ACCESSION   NZ_MPOH02000011
VERSION     NZ_MPOH02000011.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces phaeoluteigriseus
  ORGANISM  Streptomyces phaeoluteigriseus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
REFERENCE   1  (bases 1 to 1331267)
  AUTHORS   Salih,T.S., Algora Gallardo,L., Melo Santos,T., Filgueira
            Martinez,S. and Herron,P.R.
  TITLE     Draft genome sequence of Streptomyces phaeoluteigriseus type strain
            DSM41896
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1331267)
  AUTHORS   Salih,T.S., Algora Gallardo,L., Melo Santos,T., Filgueira
            Martinez,S. and Herron,P.R.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-FEB-2017) Strathclyde Institute of Pharmacy and
            Biomedical Sciences, University of Strathclyde, 161 Cathedral
            Street, Glasgow G40RE, United Kingdom
REFERENCE   3  (bases 1 to 1331267)
  AUTHORS   Schniete,J.K., Salih,T., Algora Gallardo,L., Martinez Fernandez,S.
            and Herron,P.R.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-NOV-2016) Strathclyde Institute for Pharmacy and
            Biomedical Sciences, University of Strathclyde, 161 Cathedral
            Street, Glasgow G40RE, United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 26-JAN-2017
            Assembly Method                   :: SPAdes v. 3.9; MeDuSa v. 1.6
            Genome Coverage                   :: 65.0x
            Sequencing Technology             :: IonTorrent
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001896135.2-RS_2024_05_03
            Annotation Date                   :: 05/03/2024 03:12:26
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,918
            CDSs (total)                      :: 7,837
            Genes (coding)                    :: 6,622
            CDSs (with protein)               :: 6,622
            Genes (RNA)                       :: 81
            rRNAs                             :: 3 (5S)
            complete rRNAs                    :: 3 (5S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 1,215
            CDSs (without protein)            :: 1,215
            Pseudo Genes (ambiguous residues) :: 0 of 1,215
            Pseudo Genes (frameshifted)       :: 907 of 1,215
            Pseudo Genes (incomplete)         :: 407 of 1,215
            Pseudo Genes (internal stop)      :: 30 of 1,215
            Pseudo Genes (multiple problems)  :: 120 of 1,215
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:00:38
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 306258
            Orig. end                         :: 316780
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            MPOH02000011.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10522
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="2"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10522
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10522
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5522](-)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5522)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     misc_feature    complement(180..198)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 19.31"
                     /tool="antismash"
     misc_feature    complement(191..205)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.26"
                     /tool="antismash"
     misc_feature    complement(222..236)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.53"
                     /tool="antismash"
     misc_feature    complement(223..236)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.3"
                     /tool="antismash"
     gene            324..2042
                     /locus_tag="BM536_RS44330"
                     /old_locus_tag="BM536_012445"
     CDS             324..2042
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013978.4"
                     /locus_tag="BM536_RS44330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_012445"
                     /product="bis-aminopropyl spermidine synthase family
                     protein"
                     /protein_id="WP_342748798.1"
                     /transl_table=11
                     /translation="MRSVLRALRRLAPASTRDISRATGLPVPIVAALGNELRRRDLLTK
                     ERPSRLTPAGLDVVAELGMDLTLDATCTTCEGRELVIPDVLEEAVRRLSDLMESGPAAD
                     MSIDQSHCTPETKVRRVLALLAAGALPGGNLLLIGDDDLVSLAVAVVGDVLGSPIVERV
                     TVVDISPEILAYIRKVSAGLGTRVETVEHDLRHPLPTELHSGFDVAMTDPPYTAEGARL
                     FLSRAVEGLRPGPSHSVFFSFGGKSPDEMLEVQREIMALGLVTNGYIRNFNEYQGSGIL
                     GGVGFFQHLLTTTSTASHQGDFEGPLYTGDKRTRQREYTCVACNTALRVGPGARWTSVA
                     ALRDEGCPQCGKGPFRPGRLVAADEPPTTLAVTVDEPAPAPVPVSEPAPAPAPAPIATP
                     APALAQPSHSLRPGWQRPTPESRAALEQRARPCLTRQADEGDLPAIGEFEAEIARISFG
                     EDAVDDPARHASRVGRSMEKSKEGMIVAHRPDGDTVGWCWVSINQNQMTATVTPTSAPS
                     PSPRSTTAPTSPNSSSPKAWSSAWPTASPKSSAASTSATSRCARSTASSASTPPL"
     gene            2077..2964
                     /locus_tag="BM536_RS12490"
                     /old_locus_tag="BM536_012450"
     CDS             2077..2964
                     /NRPS_PKS="Domain: FkbH (24-144). E-value: 1.1e-17. Score:
                     56.2. Matches aSDomain:
                     nrpspksdomains_BM536_RS12490_FkbH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1256: FkbH like protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR01681.1"
                     /locus_tag="BM536_RS12490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_012450"
                     /product="HAD-IIIC family phosphatase"
                     /protein_id="WP_245873471.1"
                     /transl_table=11
                     /translation="MTGATGATGASSAPDPTGYNPDRIKCVVWDLDGTLWDEIAVETLT
                     DELPVPRPEMLAAIDALAARGVLSSLASRSAPAVLDRMDAVPGLRERFLAPQVSWQDKS
                     ESLRRIAKDLGIAVEALVLIDDSPYERAEVEALLPGVRTLDPGEVPALLAAFEDREVTP
                     ESRDRVRRYRTEETRRAEGERFQGTREEFLRWCDMRLTVGPAVAEEVPRALELAARTHR
                     LNSSGLTPDRLRALAAADGHELYTARMSDRFGEYGIIGAALVDRTARGSWSCRCWRSPA
                     GSPAGAPRRRSCSG"
     aSDomain        2149..2508
                     /aSDomain="FkbH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BM536_RS12490_FkbH.1"
                     /evalue="1.10E-17"
                     /label="BM536_RS12490_FkbH.1"
                     /locus_tag="BM536_RS12490"
                     /protein_end="144"
                     /protein_start="24"
                     /score="56.2"
                     /tool="antismash"
                     /translation="KCVVWDLDGTLWDEIAVETLTDELPVPRPEMLAAIDALAARGVLS
                     SLASRSAPAVLDRMDAVPGLRERFLAPQVSWQDKSESLRRIAKDLGIAVEALVLIDDSP
                     YERAEVEALLPGVRTL"
     gene            3003..3221
                     /locus_tag="BM536_RS42765"
     CDS             3003..3221
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BM536_RS42765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_245873473.1"
                     /transl_table=11
                     /translation="MTLRPTDANLEMRILLRQAGLRRTEADDSADGSTVGDDGAVLART
                     LDSGGGGGDLPKPPAWLHVFTRKDADA"
     gene            3218..3532
                     /locus_tag="BM536_RS12495"
                     /old_locus_tag="BM536_012455"
     CDS             3218..3532
                     /NRPS_PKS="Domain: PP-binding (24-96). E-value: 3.4e-10.
                     Score: 32.1. Matches aSDomain:
                     nrpspksdomains_BM536_RS12495_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020132943.1"
                     /locus_tag="BM536_RS12495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_012455"
                     /product="phosphopantetheine-binding protein"
                     /protein_id="WP_245873474.1"
                     /sec_met_domain="PP-binding (E-value: 2.6e-07, bitscore:
                     27.3, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEAHSPSSPSTTTSSADRAAVEEELRAMIAEAARLDAAVVAGLP
                     ADTDLFGPEIGLTSLAGVTLLGAVDARFGVDVAALDLSLDSLQSIATLADFVTAHRSTL
                     "
     aSDomain        3290..3505
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BM536_RS12495_PP-binding.1"
                     /evalue="3.40E-10"
                     /label="BM536_RS12495_PP-binding.1"
                     /locus_tag="BM536_RS12495"
                     /protein_end="96"
                     /protein_start="24"
                     /score="32.1"
                     /tool="antismash"
                     /translation="ELRAMIAEAARLDAAVVAGLPADTDLFGPEIGLTSLAGVTLLGAV
                     DARFGVDVAALDLSLDSLQSIATLADF"
     gene            3668..3991
                     /locus_tag="BM536_RS12500"
                     /old_locus_tag="BM536_012460"
     CDS             3668..3991
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020132942.1"
                     /locus_tag="BM536_RS12500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_012460"
                     /product="chaplin"
                     /protein_id="WP_073490803.1"
                     /transl_table=11
                     /translation="MSRIAKAAAVAVGAGAMMVSGAGLAMADADAQGAAVGSPGVLSGN
                     VVQVPIHVPINICGNTVNIVGLLNPAFGNTCANVSNHDKGEDKHEDKGGQHHSGGDASG
                     YGG"
     gene            complement(4151..5017)
                     /locus_tag="BM536_RS12505"
                     /old_locus_tag="BM536_012465"
     CDS             complement(4151..5017)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325459.1"
                     /locus_tag="BM536_RS12505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_012465"
                     /product="tyrosinase family protein"
                     /protein_id="WP_073490800.1"
                     /transl_table=11
                     /translation="MAYIRKDVSTLTTGERRRFVRALLELKRRGEYDEFVRMHIDYYTS
                     DGERGLRTAHMTPSFLPWHRRFLLDLEKALRRVDPSVTVPYWDWTRDRATTSVPWTADL
                     LGGNGRRSDRQVMTGPFAHATGNWTIRDGVTDTEFLTRDLGRARDPIGLPTKADVEWAL
                     SDPVYDVSPWDSTVTRGFRNKLEGWGTGRGSTAWLNHNRVHRWVGGAMVGGASVNDPVF
                     WLHHAFIDLLWTRWQRRHRTHRYLPAEPPLPDSSQFRRVVARHQRLPPWNVTPDQLEDA
                     GRIYRYA"
     gene            complement(5001..5522)
                     /locus_tag="BM536_RS12510"
                     /old_locus_tag="BM536_012470"
     CDS             complement(5001..5522)
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0042438 - melanin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019065674.1"
                     /locus_tag="BM536_RS12510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_012470"
                     /product="tyrosinase family oxidase copper chaperone"
                     /protein_id="WP_073490798.1"
                     /sec_met_domain="melC (E-value: 1.1e-44, bitscore: 148.1,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVVSVDGAADVTTGPARKARRGTRRSALRGLLGATAALALAPLVA
                     ASRPARRQDSHGHGHGHVPAPAPALGLGLGANAFDETYLGRHLLGRLVPPVGVADTGRW
                     EVTVDGRPLHLMRRADGTWLSMVDHYRSYADPLEAVRAAVDELGPGQMLRPAAATGRHT
                     HMGGDHGLHP"
     misc_feature    5539..5551
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.46"
                     /tool="antismash"
     gene            complement(5663..6181)
                     /locus_tag="BM536_RS12515"
                     /old_locus_tag="BM536_012475"
     CDS             complement(5663..6181)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003976098.1"
                     /locus_tag="BM536_RS12515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_012475"
                     /product="hypothetical protein"
                     /protein_id="WP_094102929.1"
                     /transl_table=11
                     /translation="MKSTTRGTLAAVLTCVAAAAGAASATSAAAVGTVPVPVPLDGVEK
                     SLHVELPKIGGEIPVPVPGAPEGPRYVEGRLIPERVVPQLPVAAGLPGLGMRSPLPEVL
                     GDGFNHVGLDVPASDVRTLGPGLALDAPLTAPDADRFGLPDLQLPQAGVLTPVVQTVPG
                     ADLEVGQGL"
     misc_feature    6244..6255
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.12"
                     /tool="antismash"
     gene            complement(6744..7241)
                     /locus_tag="BM536_RS12520"
                     /old_locus_tag="BM536_012480"
     CDS             complement(6744..7241)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020116484.1"
                     /locus_tag="BM536_RS12520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_012480"
                     /product="DUF5949 family protein"
                     /protein_id="WP_073490796.1"
                     /transl_table=11
                     /translation="MTTTPGATRPFPVADLGTLVMMPWSGEAADGRAMPYLLACSLGNG
                     PGGHEGATAAVERLLEYSGLVVGGITDGTQKLSLPVTMLVVAGQAVVTMPWLRTQCTVP
                     PEWLEAVAERGYAYLLFTTRPWPGDAPGSTVAAEALNAFAGDEETLKAAAHIILPARSL
                     RA"
     gene            complement(7417..7698)
                     /locus_tag="BM536_RS12525"
                     /old_locus_tag="BM536_012485"
     CDS             complement(7417..7698)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007445910.1"
                     /locus_tag="BM536_RS12525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_012485"
                     /product="hypothetical protein"
                     /protein_id="WP_073490794.1"
                     /transl_table=11
                     /translation="MKSLKAAAVVAGSLVIAGAAAPAFAHDTADLTPTSLNGAVNTLTK
                     GPIDVMPLQHQSDTLDTENKNSPLSGVKDATTALNAPKSLLGGLPLQG"
     gene            complement(7868..8644)
                     /locus_tag="BM536_RS12530"
                     /old_locus_tag="BM536_012490"
     CDS             complement(7868..8644)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005479501.1"
                     /locus_tag="BM536_RS12530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_012490"
                     /product="hypothetical protein"
                     /protein_id="WP_211362871.1"
                     /transl_table=11
                     /translation="MRGLPVRRAALTALCATLLLGIAAPSALAADGEATRERTHAVPSA
                     SLSGADALLARARSLDDIKPALAPVTDLLDTSLRTASQGRSADRAKRLGAAAEDALTRV
                     AESTGPATTPSHGDRVGPGARAADITDDLLATVEKQLGALLEAATSGDVDQILPAATSL
                     VTGLSDLVTSLVDGLSLPTLPTLTDVTDVTDLTGLGDLPEVSTLPAETPALPVTTPALP
                     VTTPALPVTTPALPVTPSTLPAQASPLTPKAQAPDA"
     misc_feature    complement(8656..8669)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.21"
                     /tool="antismash"
     misc_feature    complement(8685..8699)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.32"
                     /tool="antismash"
     gene            complement(8948..9187)
                     /locus_tag="BM536_RS12535"
                     /old_locus_tag="BM536_012495"
     CDS             complement(8948..9187)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019056482.1"
                     /locus_tag="BM536_RS12535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_012495"
                     /product="chaplin"
                     /protein_id="WP_073490790.1"
                     /transl_table=11
                     /translation="MSRIAKGLVLTSVAAAAVAGASGIAAADSGAKAVAANSPGVLSGN
                     VIQVPIHIPVNVCGNTVNVIGLLNPAFGNTCIND"
     misc_feature    complement(9346..9359)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.49"
                     /tool="antismash"
     misc_feature    complement(9346..9366)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 21.09"
                     /tool="antismash"
     misc_feature    complement(9352..9365)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.47"
                     /tool="antismash"
     misc_feature    complement(9759..9772)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 18.11"
                     /tool="antismash"
ORIGIN
        1 cgggtcgctc tacggctcgc gcacgcacgc tgtcaagggg tacgccgcct ccctcatcgc
       61 cgctccccga aaattcggta agcatttccg cgaacacccc gaaacagcgt ttcccattcc
      121 tcctgttcct ttccgaattc accgatccgc gggtgcgtcc ggtcgccgcc gcgccagccc
      181 gtatactcga tagacatgta ttccatcagc ccgcccggag cagctttgtg aaaaacgcgc
      241 ctcgacaccg tcggagtacc cccgccgatc gagtgctcac agaagtcgcg gaggccgtca
      301 ggcttcagga gggcccgccc ggagtgcgtt ccgtgctgcg tgccctgcgt cgtctggccc
      361 ccgcctcgac cagggacatc agccgggcca ccggcctgcc cgtcccgatc gtggccgccc
      421 tcgggaacga gctgcgccga cgcgacctcc tcaccaagga gcgtccctcc cggctgaccc
      481 cggccggcct ggacgtcgtg gccgagctgg gcatggacct cacgctggat gcgacctgca
      541 ccacctgcga gggccgcgaa ctggtcatcc ccgacgtgct ggaggaggcg gtacggcggc
      601 tcagcgacct gatggagtcg ggcccggccg ccgacatgtc gatcgaccag tcccactgca
      661 cgcccgagac caaggtgcgc cgcgtcctgg ccctgctcgc ggcgggcgcg ctgccgggcg
      721 gcaatcttct gctgatcggc gacgacgacc tcgtctccct ggccgtcgcc gtcgtcggcg
      781 acgtgctcgg ctccccgatc gtcgagcggg tgaccgtcgt cgacatctcc cccgagatcc
      841 tcgcctacat ccggaaggtg tcggccggtc tcggcacccg cgtcgagacg gtcgagcacg
      901 acctgcgcca ccccctgccc accgagctgc acagcggttt cgacgtggcg atgaccgacc
      961 cgccctacac cgcggaaggc gcccgcctgt tcctctcgcg tgccgtggag ggcctgcgcc
     1021 ccggcccctc gcacagcgtc ttcttctcct tcggcggcaa gagcccggac gagatgctcg
     1081 aggtccagcg cgagatcatg gcgctcgggc tggtcaccaa cggctacatc cgcaacttca
     1141 acgagtacca gggcagcggc atcctcggcg gggtcggctt cttccagcac ctcctcacca
     1201 ccacctcgac cgcctcccac cagggcgact tcgaaggccc cctctacacc ggtgacaagc
     1261 ggacgcgcca gcgcgagtac acgtgcgtgg cctgcaacac cgcgctgcgc gtcggccccg
     1321 gcgcccgctg gacgtccgtc gccgcactgc gtgacgaggg ctgcccccag tgcggcaagg
     1381 gccccttccg tccgggccgc ctggtcgccg ccgacgagcc cccgaccacc ctcgcggtca
     1441 cggtggacga gccggccccc gcacccgtac ccgtatcgga acctgcaccg gcaccggccc
     1501 cggcacccat cgccaccccc gccccggcgc tcgcgcagcc ctcccactcc ctgcgacccg
     1561 gctggcagcg ccccaccccc gagtcccgcg ccgccctcga acagcgggcc cggccctgcc
     1621 tcacccgtca ggccgacgag ggcgacctcc cggccatcgg ggagttcgag gccgagatcg
     1681 cccgcatctc cttcggcgag gacgccgtcg acgaccccgc ccggcacgcg tcacgcgtcg
     1741 gccgttccat ggagaagtcg aaggagggca tgatcgtcgc ccaccgcccc gacggcgaca
     1801 cggtcggctg gtgctgggtg agcatcaacc agaaccagat gacggcgacc gttacgccaa
     1861 cttccgctcc ctcgccgtcg ccccgctcga caaccgcgcc gacgtcgccg aactcctcct
     1921 caccgaaggc ctggagttct gcctggccaa cggcatcacc gaagtcgtcg gccgcgtcca
     1981 cgtcggcaac gtcccgatgc gcacggtcta ccgcaagttc ggcttcgacc ccgccactct
     2041 gaccatgaag ctgcgcctcc cggaggagga atcccgatga ccggcgcgac cggcgcgacc
     2101 ggcgcgagca gtgcacccga cccgaccggt tacaaccccg accggatcaa gtgcgtcgtc
     2161 tgggacctgg acggcaccct gtgggacgag atcgcggtgg agaccctcac cgacgaactg
     2221 ccggtccccc ggcccgagat gctggccgcg atcgacgcgc tggcggcccg cggcgtgctc
     2281 agcagcctcg ccagccgcag cgcgcccgcg gtcctcgacc ggatggacgc cgtgcccggc
     2341 ctccgggagc gcttcctcgc cccgcaggtg tcctggcagg acaagagcga gtcgctgcgc
     2401 cgcatcgcca aggatctcgg gatcgccgtc gaggcactgg tcctgatcga cgactccccg
     2461 tacgagcgcg ccgaggtgga ggcgctgctg ccgggcgtgc gtaccctcga ccccggcgaa
     2521 gtcccggcgc tgctggcggc gttcgaggac cgcgaggtca cccccgagtc gcgggatcgg
     2581 gtgcgccgct accgcaccga ggagacccgc cgggccgagg gcgagcgctt ccagggcacc
     2641 cgggaggagt tcctgcgctg gtgcgacatg cgcctcacgg tcggcccggc cgtcgccgag
     2701 gaggtcccgc gggcactgga actcgccgcg cgcacccacc gtctgaactc ctccggcctg
     2761 acccccgacc ggctccgcgc gctcgccgcc gcggacgggc acgagctgta caccgcccgg
     2821 atgtccgacc gcttcgggga gtacggcatc atcggcgccg ctctcgtcga ccggaccgcc
     2881 cgcggttcct ggtcgtgccg ctgctggcgc tctcctgccg ggtcgccggc cggggcgccg
     2941 cggcggcgtt cctgttctgg ctgatggagc gggcgcggga gtccggtgca gaggacttcc
     3001 gggtgacact gcggccgacg gacgccaacc tggagatgcg gatcctgctc cgccaggcgg
     3061 gcctgcgccg tacagaagcc gacgacagcg ccgacggcag cactgtcggc gacgacgggg
     3121 cggtcctggc ccgcaccctc gacagcggtg gcggtggcgg cgacctgccg aagccccccg
     3181 cctggctgca tgtcttcacc cgaaaggacg ccgacgcgtg accgaggccc actccccctc
     3241 ctccccctcc accaccacct cctccgcgga ccgcgcggcg gtggaggagg agcttcgcgc
     3301 gatgatcgcg gaggccgccc gtctggacgc cgccgtggta gcaggactcc ccgccgacac
     3361 cgacctgttc ggcccggaga tcggcctgac ctcgctggcc ggggtgacgc tgctgggcgc
     3421 ggtcgacgcc cgcttcggcg tcgatgtcgc cgcgctggac ctcagcctgg acagcctcca
     3481 gtccatcgcc accctggccg acttcgtgac ggcgcaccgg agcaccctct gaggcgcact
     3541 cccccgcgcg tgcgcgacaa gggtgatcgg cggatgccgc cgtgacctgc ccggggggcc
     3601 ggcgttgaac ggggagtgcg gtggcgcgac ctgctgccgt gcgaaccgaa ccacaaagga
     3661 gaatgtgatg tctcgcatcg cgaaggcagc cgctgtcgcc gtcggcgccg gcgccatgat
     3721 ggtcagcgga gccggcctgg caatggcgga cgcggacgcg cagggtgcgg ccgttggctc
     3781 gccgggcgtc ctgtccggca acgtggtcca ggtcccgatc cacgtgccga tcaacatctg
     3841 cggcaacacc gtcaacatcg tcggcctgct caacccggcc ttcggcaaca cctgcgccaa
     3901 cgtcagcaac cacgacaagg gcgaggacaa gcacgaggac aagggcggcc agcaccacag
     3961 cggcggcgac gccagtggct acggcggctg acgtcagctc gcagcagcac ccctaaggga
     4021 gagccccggc acctcgagcg ccggggctct ccccttttcc ctgcctccct cacgcgtacc
     4081 ggcagctttc cctgccgcct ctcgtgtacc ggcagcgctc acgcgtaccg tcggccatac
     4141 cgtggccgcc tcacgcgtac cggtagatcc gtcccgcgtc ctccagctgg tcgggggtca
     4201 cgttccacgg aggcagcctc tggtgccggg cgacgacccg gcggaactga ctgctgtccg
     4261 gcagcggcgg ttcggcgggc aggtagcggt gtgtcctgtg gcgtcgctgc cagcgggtcc
     4321 acagaaggtc gatgaaggcg tggtggagcc agaacaccgg gtcgttgacg gacgccccgc
     4381 cgaccatggc cccgccgacc caccggtgca cccggttgtg gttgagccag gcggtgctgc
     4441 cccggccggt cccccacccc tccagcttgt tgcggaagcc gcgggtcacc gtcgagtccc
     4501 agggcgagac gtcgtagacc gggtcgctca gcgcccactc cacgtcggcc ttcgtcggca
     4561 gcccgatcgg gtcgcgggcc cggccgaggt cgcgggtgag gaactccgtg tcggtgacgc
     4621 cgtccctgat cgtccagttg ccggtggcgt gggcgaacgg ccccgtcatc acctgccggt
     4681 ccgagcgccg accgttgccg ccgagcaggt ccgcggtcca cggcacggag gtcgtcgccc
     4741 ggtcccgcgt ccagtcccag tacggcaccg tgaccgaggg atcgacccgg cgcagcgctt
     4801 tctccagatc cagcaggaac cggcggtgcc agggcaggaa ggagggcgtc atgtgggccg
     4861 tgcgcaggcc gcgttcgccg tcggaggtgt agtagtcgat gtgcatgcgc acgaactcgt
     4921 cgtactcgcc ccggcgtttc agctccagca gggctcggac gaagcgtcgg cgttcgccgg
     4981 tggtgagtgt gctgacgtcc ttacggatgt aggccatggt ctccccccat gtgtgtgtga
     5041 cggccggtgg cggcggcggg ccgcagcatc tgtccggggc ccagttcgtc gacggcggct
     5101 cggaccgcct cgagcggatc ggcgtacgag cggtagtggt cgaccatgct cagccaggtg
     5161 ccgtcggcgc ggcgcatgag gtgcaggggg cggccgtcga cggtgacctc ccagcggccg
     5221 gtgtcggcaa cgccgaccgg cggaacgagg cggccgagca ggtggcggcc gaggtaggtc
     5281 tcgtcgaagg cgtttgcccc gagcccgagc ccgagcgcgg gtgcgggtgc gggcacatgg
     5341 ccgtggccgt gaccgtggct gtcctggcgg cgggccggcc gggaggcggc caccagcggc
     5401 gcgagtgcga gggccgcggt ggcgccgagc agtccgcgca gcgcactcct gcgtgttccg
     5461 cgtctcgcct tccgtgccgg gcccgtggtc acgtcggcgg ctccgtccac actgacgacc
     5521 atgtgtgctc ctcgtccggt tccgttgtca cagcggtaac cgtccgacgg cccgcggggt
     5581 caccgtgcgg accggaaagc ggccgggaaa ggcgacaggc ccggacggcg ggtccgggcc
     5641 tgtggtcggg tgggccggtc ggctacaggc cctggccgac ctcgaggtcg gcgcccggca
     5701 ccgtctggac gaccggggtg agcacaccgg cctgcggcag ctgaaggtcc ggcaggccga
     5761 accggtcggc gtcgggtgcg gtgagcgggg cgtccagggc gaggccgggg ccgagggtgc
     5821 gcacgtcgga ggcggggacg tcgaggccga cgtggttgaa cccgtcgccg aggacctccg
     5881 gcagcggcga gcgcatgccc agaccgggaa gcccggcggc gaccggcaac tgcgggacca
     5941 cgcgctccgg gatgaggcgg ccctcgacgt accgcgggcc ttcgggggcg cccggcaccg
     6001 gcaccgggat ctcgccgccg atcttgggca gttccacgtg gagggacttc tcgacgccgt
     6061 ccagcgggac ggggacggga accgtgccga ccgcggcggc tgaggtcgcg gaggcggcgc
     6121 cggccgcggc cgccacacag gtgagcacgg cggcgagggt tcctcgggtg gtcgacttca
     6181 tctcgggtac ggtccctttc ggagtgctgg acgggctgtg cctgcgtacc gggtaacgag
     6241 ccggaaaacg acatcagttc acaaatccct cggatgccgc attcgtacga cagtgggatg
     6301 gtcgggccgt ccggacatgc caccggcgag tcgtacgggc ggtgtccctg gtgggccgtg
     6361 gcgcacgccg cgggtgcccg ggccggggtc gggaaccccg cggtcgtggc gatccacgcc
     6421 ggagcgcatc ggcggcacgg cacgttcgcc caggtgcccg gagtcgggcc ggggccggac
     6481 gccaggagcc ggacaggaca caggacagca ccggcgcgac agcagggcag ggggtcagcg
     6541 ccgggtgccg gcttgggatc cagggacttc gcggctcggc cggcggggac gacccgcgag
     6601 gccgccacgc cgccacgccg ccacttcgcc acgccgccac accggcaccc cgccacacgg
     6661 ggagtgccga cgacggcgtg ggcccccggc caccaccggc cgccaccggc cgctacggcc
     6721 accgtcaggc gccgccgagc ccctcaggcg cgcaggctac gggcgggcag gatgatgtgc
     6781 gcggctgcct tcagggtctc ctcgtcgccg gcgaacgcgt tcagcgcctc ggcggcgacc
     6841 gtcgaaccgg gcgcgtctcc gggccagggg cgggtggtga agaggaggta ggcatagccg
     6901 cgctcggcca ccgcctcgag ccactccggc ggcaccgtgc actgggtcct gagccatggc
     6961 atggtcacga cggcctggcc ggccacgacc agcatggtga cgggcagact cagcttctgg
     7021 gtgccgtcgg tgataccgcc cacgaccagg ccgctgtact ccagcagcct ctcgacggcg
     7081 gcggtcgcgc cctcatggcc gccgggaccg ttgccgaggg aacaggcgag gaggtagggc
     7141 atcgcgcggc cgtccgcggc ctcgccgctc cacggcatca tgacgagggt tccgaggtcg
     7201 gcgacgggga aggggcgggt tgcgccgggg gttgtggtca ccgcgcgacc ctaaggcgtc
     7261 ccggcggtcc gcccggacgg ttgtcacccg ggcggaggac accgggcggg tgctccacac
     7321 gaacgaggga ccggtccgcc gacccgcctc gaacaccgcg gacggccggt ccgtccgtgg
     7381 cgcgagccgc gtccggaagg cctccgggcg gtgacgtcag ccctgcaggg gcaggccgcc
     7441 gaggagcgac ttcggggcgt tgagcgcggt ggtcgcgtcc ttgacgccgc tgagcgggga
     7501 gttcttgttc tccgtgtcga gcgtgtccga ctggtgctgc agcggcatca cgtcgatggg
     7561 gcccttggtg agcgtgttga cggcgccgtt gaggctggtg ggcgtgaggt cggcggtgtc
     7621 gtgcgcgaat gccggtgcgg cggcacctgc gatcacgagg gatccggcaa cgacagcggc
     7681 agccttcagg gacttcatcg gggacctttc ttcggcaact cggcaactcg gcaactcaag
     7741 tcaccagcga gactctgacg ccgtgtctaa cgatgtgcgg cgacggcgga aaccccggac
     7801 gcggaagaat tccgcacccc gacacgggcc cacccgaacg ccgaggtgcg gaaaggggaa
     7861 ccggccgtca ggcgtcgggg gcctgcgcct tgggggtgag cggcgacgcc tgcgccggca
     7921 gggtggacgg cgtgaccggc agggccgggg tcgtcaccgg cagggccggg gtcgtcaccg
     7981 gcagggccgg ggtcgtcacc ggcagggccg gggtctcggc cggcagggtg gagacctcgg
     8041 gaaggtcgcc caggcccgtc aggtccgtca cgtccgtcac gtccgtcagg gtcggcaggg
     8101 tcgggagtga caggccgtcc accagggagg tgaccaggtc gctcaggcct gtcaccaggc
     8161 tcgtggccgc ggggaggatc tggtcgacgt cgccggaggt ggccgcctcg agcagcgcgc
     8221 cgagctgctt ctccacggtg gcgagcaggt cgtccgtgat gtcggcggcc cgtgccccgg
     8281 ggccgacgcg atcaccgtgg gacggcgtcg tggccgggcc ggtggactcg gccacccgtg
     8341 tcagagcgtc ctcggcggcg gcgcccagcc tcttcgcccg gtcggcgctc ctgccctggc
     8401 tggcggtcct cagcgaggtg tcgagcaggt cggtgacggg agcgagcgcg ggtttgatgt
     8461 cgtccaggct ccgggccctg gcaagcagcg cgtccgcgcc ggagagagac gcactcggca
     8521 ccgcatgagt gcgctcgcgg gtcgcttccc catcggcggc cagggcggag ggagcggcga
     8581 tgccgagaag gagggtggcg cacagcgcgg tgagggcggc acgccgaacg ggcagaccac
     8641 gcatgggggt tcctttcgat atgcgtcgag tcgcaggttc agcgtgaaag cgcgtgtcac
     8701 gcccgcaaca gcacagttgc cttccgtcac ccccgcgtgt gacgtgcccc ctggcgggac
     8761 ggcacggcac ggtccaccgg gcggtcgcgg caccctgccg ccattcgtgg cgacacgcgg
     8821 gagcgacggc cgcgacacct tgggcccgac gggtgggcca cctgcacgga caacgcgaac
     8881 ggccgccctc ctgacggaag ggcggccgtc tgacgtcgca cgcgtcgtga cctcggtcga
     8941 ggtgacgtca gtcgttgatg caggtgttgc cgaacgccgg gttcagcagc ccgatcacgt
     9001 tgacggtgtt gccgcagacg ttgaccggaa tgtggatcgg aacctggatg acgttgcccg
     9061 acagcacgcc cggggagttg gcggcgacag ctttggcgcc actgtcggcg gcggcgatgc
     9121 cggaggcgcc ggcgacggcc gcggcggcaa cggaggtcag gaccaggccc ttcgcgatac
     9181 gcgacatgga gaggtgctcc ttgggggttt tgacacatac acccgggcgg ggatgcccgg
     9241 cggtgtgtca acgcgtgaaa gcgcccggag ttttgcctcc gaacgggtga cgtgacggcg
     9301 tcccggtctt cacaactccg acacagatgc ccgacttctc cttgttaatc ctgattatga
     9361 ctagagtgac ggctcgtccc gcccgcttgt cgccagcaca ccgcacctgc tccgaaaggg
     9421 ccacgccggt catgcgccat tccctgggtc cgctgctgcg ccgggcgtcg gtggtcttcc
     9481 tcgccctcgc ctccctttgt gccccgggcg gcgccctggc cgccccggcg ccgccctccg
     9541 ccgaggccga gcgcctcgcc ttcacccagc ggtaccgcgc gaccttcacc cagcggtacg
     9601 gcgcgacctt cacccagcgg taccgcgcga cccagcacgg cggcatcgcc cgggcggcca
     9661 actcggccgt cagctgccgt acgacaccgg cgtccgccac ccgaaccgcg cctgcctgca
     9721 cggctgtccg ggaggggcgg gcggcggcca acggcgactt ggacatgttc tacgtcgatg
     9781 tcgaccgcga cccgaacacc tacaactcct cccgcgccga ggtccgcctc cccgagggct
     9841 cccgggtgac gtacgcgcgg ctgtactggg gcggcaatct gcgcgtcggt gagcggaagt
     9901 cgcccaagga caacgggcgg gtgctcgtcg cggagccggg cggcgcgtac aaggcggtgc
     9961 tcgcggacac cgtcaccggc caccgggtgg ctcggggcgc cgacgccttc caggcctccg
    10021 cggacgtcac ggggctggtg cgcgagagcg gggcgggcct gtacacggtg gcgcaggtca
    10081 acatggcgat gggcaggtcc gcggccggtg cgtggggcgg ctggacgctg gtggtggcgt
    10141 acgagaaccc gcgggagccg ttgcggcacc tcgcggtgtg ggacggcttc gacgcgctag
    10201 gtccgggcgc ggggcaggag atccggctgc gcggggtgcc gttcccgcgc ggtgcgggcg
    10261 gccgggcggg gctggtcgcc tacgacggcg accgcggccg ttcgggtgat tcgatcacgt
    10321 tctcgacggc tcgcgggggg tctcggcgct ctccgacccg gtcaatccat ctgacgatgt
    10381 gttgaactcc acgatcagcg agccgggggc ggctccggcg gcgcgtgtcc cggcgtacgc
    10441 caacacactc ggttacgact ccgatgtgtt cgatctgcga gcggatttgc ggcgcggcgg
    10501 tgaccagctg gccttccggc tc
//
