LOCUS       NZ_MPOH02000009        28490 bp    DNA     linear   CON 03-MAY-2024
DEFINITION  Streptomyces phaeoluteigriseus strain DSM 41896 Scaffold_9, whole
            genome shotgun sequence.
ACCESSION   NZ_MPOH02000009
VERSION     NZ_MPOH02000009.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces phaeoluteigriseus
  ORGANISM  Streptomyces phaeoluteigriseus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
REFERENCE   1  (bases 1 to 758978)
  AUTHORS   Salih,T.S., Algora Gallardo,L., Melo Santos,T., Filgueira
            Martinez,S. and Herron,P.R.
  TITLE     Draft genome sequence of Streptomyces phaeoluteigriseus type strain
            DSM41896
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 758978)
  AUTHORS   Salih,T.S., Algora Gallardo,L., Melo Santos,T., Filgueira
            Martinez,S. and Herron,P.R.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-FEB-2017) Strathclyde Institute of Pharmacy and
            Biomedical Sciences, University of Strathclyde, 161 Cathedral
            Street, Glasgow G40RE, United Kingdom
REFERENCE   3  (bases 1 to 758978)
  AUTHORS   Schniete,J.K., Salih,T., Algora Gallardo,L., Martinez Fernandez,S.
            and Herron,P.R.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-NOV-2016) Strathclyde Institute for Pharmacy and
            Biomedical Sciences, University of Strathclyde, 161 Cathedral
            Street, Glasgow G40RE, United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 26-JAN-2017
            Assembly Method                   :: SPAdes v. 3.9; MeDuSa v. 1.6
            Genome Coverage                   :: 65.0x
            Sequencing Technology             :: IonTorrent
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001896135.2-RS_2024_05_03
            Annotation Date                   :: 05/03/2024 03:12:26
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,918
            CDSs (total)                      :: 7,837
            Genes (coding)                    :: 6,622
            CDSs (with protein)               :: 6,622
            Genes (RNA)                       :: 81
            rRNAs                             :: 3 (5S)
            complete rRNAs                    :: 3 (5S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 1,215
            CDSs (without protein)            :: 1,215
            Pseudo Genes (ambiguous residues) :: 0 of 1,215
            Pseudo Genes (frameshifted)       :: 907 of 1,215
            Pseudo Genes (incomplete)         :: 407 of 1,215
            Pseudo Genes (internal stop)      :: 30 of 1,215
            Pseudo Genes (multiple problems)  :: 120 of 1,215
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:00:38
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 149716
            Orig. end                         :: 178206
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            MPOH02000009.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..28490
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..28490
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..28490
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:18490]"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..18490
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            453..842
                     /locus_tag="BM536_RS08460"
                     /old_locus_tag="BM536_008400"
     CDS             453..842
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BM536_RS08460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BM536_008400"
                     /product="hypothetical protein"
                     /protein_id="WP_073492294.1"
                     /transl_table=11
                     /translation="MGTATEFPEARDMTGEELCPGEALVALCRYGRRPLPRDVFVRLRH
                     ADGFTPSRALALHTVLSVLSMLSVTRYGATRHAVDGRTVPAGIPPAIAFVGLPTAPHPE
                     DIGRLAELAIHRPTTSARRSARSSS"
     gene            839..961
                     /locus_tag="BM536_RS43925"
     CDS             839..961
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BM536_RS43925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_281258551.1"
                     /transl_table=11
                     /translation="MMAAGADLASVALFLGLSAFEQLKAVRVMRPGPTRTDPGV"
     gene            962..1834
                     /locus_tag="BM536_RS08465"
                     /old_locus_tag="BM536_008405"
     CDS             962..1834
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010286840.1"
                     /locus_tag="BM536_RS08465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_008405"
                     /product="phosphatase PAP2 family protein"
                     /protein_id="WP_079274946.1"
                     /transl_table=11
                     /translation="MPLRFTTRRSRERRRREADHRFGVRLLGAAVVAALAAVAFGLLVV
                     LVEGRWQPLRRLDASAARRLNETALDHPAWTGTLRLLSDWVWDPVTLRVVVALLTLWLL
                     RRGAWRLAAWSAVTAVAGGLIGVLVKVVVERARPTLEDPVAHAPGYSFPSGHAMTATTS
                     FAILLLVLLPIVPRAWRAGCWCFAVLSVLGVGFTRVALGVHWFSDVVGGWLLGLVVVAL
                     TAGAFEAWRADIGRRTTELADGLEPELSGPHPEPSVLSAPTRRRSAPVPGGHRAGGPAS
                     GARVFRRHR"
     misc_feature    2036..2052
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.9"
                     /tool="antismash"
     misc_feature    2051..2065
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.25"
                     /tool="antismash"
     gene            2107..4218
                     /locus_tag="BM536_RS08470"
                     /old_locus_tag="BM536_008410"
     CDS             2107..4218
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035: MMPL domain-containing transport protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018854274.1"
                     /locus_tag="BM536_RS08470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_008410"
                     /product="MMPL family transporter"
                     /protein_id="WP_073492292.1"
                     /transl_table=11
                     /translation="MRTTPRWARWLVPLVLLVAWLGVGGTLGPYAGKLGEVATNDQAAF
                     LPQSAESTKVLKAREAFDQSETLPAIVVWTADDGRVTEAQRSSATRAIDGLAGRSGVVG
                     APSPALPSEDGKALQAVVQLEPDLGDGLPDVLSEVREAARSVPGATAQIAGPAASQADL
                     SDAFAGIDGLLLGVALAAVLLILLLVYRSILLPFLIILGSVFALGLACGIVYVLADHDV
                     VRVDGQVQGILSILVIGAATDYALLLAARFREELVLREDPSSAALAAVRRSFGAIAASA
                     ATVALALLALLASDLTNNRALGPVGAIGIVCAALSSLTFLPAVLALLGRSAYWPSRPKA
                     SDASDRGHGVWRRVAALVASRPRRIWVVTALGLAVFAAFSPSLSAKGVPLDEIFVNDAP
                     SVAAQQTLGEHFPGGSGNPAVIIADADRTAQVTAAARETEGVASADAVSASGRPGAREP
                     LVADGRVRIDATLEASADSDGAKQTVERLRANLHAVPGADALVGGYTAQQYDTQQTAAR
                     DRTLIVPVVLVIILVILVLLLRSLLVPLLLVATVALNFLATLGVSALVFEHLLGFSGTD
                     ASVPLYGFVFLVALGVDYNIFLMSRVREEALAHGNRQGVLRGLTTTGGVITSAGVVLAA
                     TFAALMVIPLAFLVQIAFIVAFGVLLDTLVVRSLLVPALVLDIGPRAWWPSHLAHEDTG
                     HATGQQPST"
     gene            4486..5466
                     /locus_tag="BM536_RS08475"
                     /old_locus_tag="BM536_008415"
     CDS             4486..5466
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012792.4"
                     /locus_tag="BM536_RS08475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_008415"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_073492291.1"
                     /transl_table=11
                     /translation="MIPPAEERKRGTGPVSVRPLGEADLDRADEIFRVAFGTFLGAPEP
                     KTFFGTADYVRTRWAADPHAAFAATVEGEVVASNFAVNWGSVGYFGPLTVHPDLWDQGI
                     GRRLMEPVMECFGTWGNRHLGLFTFSHSAKHLELYRRYGFWPRFLTAIMKKQIAGSTAV
                     PGRALYGELPAAERLDALSLCRTLTGAVFEGLDVEREIVATHAQGLGDTILLQGAGSDL
                     DGLAVCHCGPGSEAGEDVCFVKFGAVRPGPEAADRFERLLTACERLAAERGLGQLDAGM
                     NLARQDAYRRMVDRGFRTWLQGVAMHRPNEPGYSHPDAYVIDDWR"
     gene            <5725..>5817
                     /locus_tag="BM536_RS42605"
                     /pseudo=""
     CDS             5725..>5817
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014152516.1"
                     /locus_tag="BM536_RS42605"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="short-chain dehydrogenase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSGPASVVLANAGAAEGGPLAESDPAVWRRV"
     gene            6345..7919
                     /locus_tag="BM536_RS08485"
                     /old_locus_tag="BM536_008425"
     CDS             6345..7919
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014157567.1"
                     /locus_tag="BM536_RS08485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_008425"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_094102763.1"
                     /transl_table=11
                     /translation="MAATDGQRNGERLRCLVTGASGYIGGRLVPELLQAGHRVRCLARS
                     PGKLRDHPWAQDAETVRGDVTDAASVAKAMRGVDVAYYLVHALGTGSTFEDTDRRAARI
                     FAEQAHAAGVRRIVYLGGLTPKGVSERSLSPHLRSRAEVGRIFLDAPVPATVLRAAIVI
                     GSGSASFEMLRYLTERLPVMVTPSWVHTRTQPIGVHDVLRYLVGSATMPPDVDRAFDVG
                     GPDVLTYREMMRRYAVIAGLRRRLIVPVPVLTPRLSSHWVGLVTPVPASIARPLTESLR
                     HEVVCHEHDIARYLPDPPGRPLPFDEALALALRRVRDVQVAARWSSDVAPGAPSDPLPT
                     DPDWAGGSLYEDDRHLPVDASRASLWKVVEGIGGDNGWYSFPLAWAVRGWLDRFVGGVG
                     PRRGRRDAERLRVGDPLDFWRVEEIEPGRLLRLRAEMRLPGLAWLEMYVETDTAGRTRY
                     RQRTLFHPRGLLGHAYWWGVAPFHAVVFGGMARNIAQAAAKGTRAPGRAPRTDRTGHAR
                     FVRIIRR"
     gene            8369..9865
                     /locus_tag="BM536_RS08490"
                     /old_locus_tag="BM536_008430"
     CDS             8369..9865
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018843427.1"
                     /locus_tag="BM536_RS08490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_008430"
                     /product="cryptochrome/photolyase family protein"
                     /protein_id="WP_094102866.1"
                     /transl_table=11
                     /translation="MHWLFGDQLGPHFLTPGDGGPGRDTPLLMIEARSVFRRRRFHRAK
                     AHLILSAMRHRAAELGERMTYVRADTYRQGLEEAAGDRPVTVHHPTSYAALRLVRSLPQ
                     VTLSPARGFLVPMDDFAAWADGQGGERLRQEDFYRWVRKGHDLLMDGDAPAGDRWNLDH
                     DNRQPPPRAASTLQVPAPFRPREDEIDDEVRHDLDRWERDGDVAFVGRDAPRAFPASRA
                     EARAALKRFLTHRLPTFGPYEDAVLAADPVMSHSLLSSSLNLGLLDPAECVERAEAEWR
                     AGRAPLNSVEGFVRQIAGWREYVWQLYWYFGEDYRRSNVLRHTAALPHWWSELDADAVE
                     ARCLRTVLSQVRDTGWTHHIPRLMILGSYALQRGWDPAAVTDWFHRCFVDGYDWVMVPN
                     VVGMSQYADGGRMTTKPYTSGGAYVHRMSDLCGPCRYRPGDRTGEQACPYTAGYWAFLD
                     RHRDRLGRNHRTARPVHQLGRLTDLPEVRRQERDRGDAPP"
     gene            10001..11143
                     /locus_tag="BM536_RS08495"
                     /old_locus_tag="BM536_008435"
     CDS             10001..11143
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006345137.1"
                     /locus_tag="BM536_RS08495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_008435"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_094102867.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.6e-46, bitscore:
                     154.0, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLGLRPTVAEPVGRADGPLTAREGARAAEAELGRVLDDVLGRARE
                     ADPVFARDIADRVASLVLRGGKRLRTAFAWCGWRAAGGTGDATPVLRTGAALELVQACA
                     LIHDDLMDGSPLRRGAPAVHVDLARMHETARMTGSPETFATSAAVLAGDLALAWADDLM
                     TETVLGSPHGPQLHREWQAMRTEMVAGQYRDIHAQATGASGVDEAVTIATLKSALYTVE
                     RPLALGASLAGADATVLDALRSAGRCAGLAFQLRDDILGAFGDPAETGKSSEDDLRTRK
                     LTYLLAVGSRLAEASGDREAADVLAPGAPSVSDDTVRRMRAALERTGARAVVESKVTEL
                     AATSLRHFDRTGAEPSVRREFAALVGRASGMAPHRTGEAA"
     misc_feature    complement(10023..10037)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     gene            11140..12711
                     /locus_tag="BM536_RS08500"
                     /old_locus_tag="BM536_008440"
     CDS             11140..12711
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019979882.1"
                     /locus_tag="BM536_RS08500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_008440"
                     /product="phytoene desaturase"
                     /protein_id="WP_094102764.1"
                     /sec_met_domain="DAO (E-value: 7.6e-17, bitscore: 57.2,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTVAGPTDHVVVVGAGLSGLACALHLLGAGRRVTVVERDDGPGG
                     RAGRVRLGGYEIDTGPTVLTMPHLADEAFAAVGDSLDRHVELTALHPAYRACFADGSSL
                     DVHTDGEAMEAEVRRFAGPAEAAGYRELRDWLERLYRAQMRRFIDTNFDSPFQLLHPDL
                     ARLAALGGFGRLDRRIGRFLADPRLRRVFSFQALYAGVAPARALAAYAVIAYMDTVAGV
                     WFPKGGMHALPRGMANAAAQTGAEFRWSAEATMLERSGDRVRAVRLASGESIRCDAVVL
                     TCELPAAHRLLGRAPKRPVRLRHSPSSVVLHAGTDRTWPGLAHHTLSFGAAWERTFDQL
                     TRTGELMSDPSLLITRPTTHDPGLAPPGRHLHYVLAPCPNTDVGPSGAEWRDLGPRYRD
                     CLVAELERRGLDGFADSVQEELLVTPLDWTAQGHAAGSPFSVSHTFAQTGPFRPRNLVR
                     GLENVVLAGCGTTPGVGVPTVLISGKLAAGRVTGGRTGIRHVHTRPARRGTRAVAPTAE
                     GAHDPS"
     gene            12698..13696
                     /locus_tag="BM536_RS08505"
                     /old_locus_tag="BM536_008445"
     CDS             12698..13696
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019979883.1"
                     /locus_tag="BM536_RS08505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_008445"
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_094102765.1"
                     /sec_met_domain="phytoene_synt (E-value: 2.2e-124,
                     bitscore: 409.4, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 9e-65,
                     bitscore: 214.2, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRRELDAAGITDPALRAAYTECRRLNARHGKSYFLATRLLPVER
                     RSAVHALYGFARWADDIVDDLDRHRTPRERDRRLMRLEDDLARGLRTGTGDEPVVRAVA
                     DTAERYDIEHTLFADFLASMRSDLHVTDYPTYADLRTYMHGSAAVMGLQMLPVLGTVVP
                     REEAAPHAAALGVAFQLTNFLRDVGEDLDRGRVYLPADLLAAHGVDRPMLEWSRRTGRT
                     DPRIRAALVAAEDLTRKVYRAAEPGIAMLDPRTRPCIRTAFALYGGILDAIADQGYTVL
                     QRRAVVSRVRRAATATAGVVQIAGARWRAVRTDRRAPQPGVTPLPWKGPVK"
     gene            13693..14699
                     /locus_tag="BM536_RS08510"
                     /old_locus_tag="BM536_008450"
                     /pseudo=""
     CDS             13693..14699
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018524373.1"
                     /locus_tag="BM536_RS08510"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_008450"
                     /product="DUF5914 domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSDRADRTRWTPPLRRAAGRTGRPRHRRGARPARL"
     gene            complement(14986..16539)
                     /locus_tag="BM536_RS08515"
                     /old_locus_tag="BM536_008455"
     CDS             complement(14986..16539)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978679.1"
                     /locus_tag="BM536_RS08515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_008455"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_073492285.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.7e-07, bitscore:
                     26.1, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 5.5e-14, bitscore: 47.8,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSARRQATRRGRDRKAEIIMPAPGRDRFDREDAPSVAVVGAGIAG
                     LAAATLLAERGARVTLYEREDSLGGRLTGWPTRLSDGSRATMSRGFHAFFRQYYNLRGL
                     LRRTDPGLDRLRPLPDYPLRHSGGLTDSFARVPRTPPFSALGFVVLSPTFGWRDLAGMD
                     ARAALPLLDVRVPEAYERFDDMSATAFLERVRFPEAAHHLAFEVFSRSFFADPRELSAA
                     ELLLMFHIYFLGSAEGLLFDVPDEPFPQALWEPLGDYLQSLGAVIRTGTPVRGVHPDDA
                     GGLEVRTDDALDRYEAAVLALDPGALREVVAASPGLGTPVWRDDIASLTTAPPFLVSRL
                     WLDRPVRADRPGFLGTSGFDGLDNISVLDRYEGEAARWAARSGGSVVELHAYAVAAGSA
                     PQTVQNRLIDSLHRVYPETRQARILDARHAWRSDCPFFPVGSHTRRPTVLTPHPRVTLA
                     GDAIRSDLPVALMERAATTGFLAAGALLADWGVRGQTLWTVPRAGRSTVLRALSRVGNR
                     "
     gene            complement(16536..17270)
                     /locus_tag="BM536_RS08520"
                     /old_locus_tag="BM536_008460"
     CDS             complement(16536..17270)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006345142.1"
                     /locus_tag="BM536_RS08520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_008460"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_073492283.1"
                     /transl_table=11
                     /translation="MTLLRDHELACAFDHASHTYDRLTALNPGYRTDLLRSARRLRLPR
                     AGAGLHVLDLGCGTGASTRALLRAAPRARITAVDASSGMLRRALAKQWPAQVRFQHLTA
                     EEVVTTGEGPYDAVFAAYLFRNVTDPDGVLAAVRSLLRPGGRLAVHEYSLSGSAVHRAL
                     WTAVCQAVIIPAGTLSGDRALYRHLWRSVLAFDTVPAFTARLSDAGFTGVRAVPVAGWQ
                     TGIVHTFLASRDDASPYAEDAR"
     gene            complement(17267..18490)
                     /locus_tag="BM536_RS08525"
                     /old_locus_tag="BM536_008465"
     CDS             complement(17267..18490)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006345143.1"
                     /locus_tag="BM536_RS08525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_008465"
                     /product="lycopene cyclase family protein"
                     /protein_id="WP_094102767.1"
                     /sec_met_domain="Lycopene_cycl (E-value: 8.8e-103,
                     bitscore: 339.6, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRQPPASGGPCDVVIVGGGAAGLSLAHRLTASFSPTVTLVEPPD
                     GPLRPPERTWCYWDRGAADLDEAVSASWTRLRVHGTDGRAITVHPSPLTYRMLRSTDFE
                     RLVHHRLSTSPGVRVLRATADIVRNTADGAEVRCTGPDGRTLWLRARHVFDSRPRRALP
                     PARTRLLQHFRGWFVHTGTDRFDPEVADLMDFRVPQPRHGLAFGYVLPLAPDRALVEYT
                     EFSRTALTTEAYETALAHYCRDVLRLDAFTVESAEQGAIPMTDARFARQVGPAVFRIGT
                     AGGATRPATGYTFAAVQRQSRAIAAALHAGHVVVPPPHGRRALAMDAVLLRALDEGRIN
                     GPDFFTDLFRRVPPERLLRFLDGDTSPWEEWSIGLRTPVGPMLRTAVELPFLPRRSRPA
                     PPTGEDHR"
     gene            complement(18487..19197)
                     /locus_tag="BM536_RS08530"
                     /old_locus_tag="BM536_008470"
     CDS             complement(18487..19197)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018849740.1"
                     /locus_tag="BM536_RS08530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_008470"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_094102768.1"
                     /transl_table=11
                     /translation="MDLSGARVLVAGATGVLGGALTAELAGRGACPALAGRDPARLAQV
                     AQACPGAPTVLFDAYDPASCARAVHDAKAALGGLDAVVAAFGAVAFGRAAEVGDEVAEH
                     LYAVNVLAPAALFRAALTVMGPGSVIAAFTGVVAEHPQAGMADYSASKAALSAWLGAVR
                     REVRTNGIRVLEARPGHLDTGFADRPVAGTAPPMPAGGDPHRVVAALADAMETDAELLF
                     TAPDGTPVVERRAR"
     gene            complement(19299..20546)
                     /locus_tag="BM536_RS08535"
                     /old_locus_tag="BM536_008475"
     CDS             complement(19299..20546)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014152490.1"
                     /locus_tag="BM536_RS08535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_008475"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_094102769.1"
                     /sec_met_domain="DAO (E-value: 1.7e-09, bitscore: 33.0,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSQQRGTPDTVVVGAGLAGLACALDLCRAGRSVALLEASDGVGG
                     RMRTDRRDGFLLDRGFQVFNTSYPQVKRRLNLRNLQLRPFTPGIIARTSTGDVRLADPT
                     RQPRAARSLLPGRVLPAGDLAAMGALTARDALLPAALLKHGPDRSTAAALSRAGLSERT
                     VSEILRPFLSGVFLEDRLETSARFFHLVWRSMVRGTLCLPAHGVGAVPAQLADGLPEGV
                     LRLETPVDMLTPEGVLLTDGRELPAASVVVATDAATAARLLPGLDAPAGRTVTTYYHAA
                     ASPPLSEPTLMVDSSGDVLNTCVLTEVTSTYAPPGTALIATSVLGGDRPGAGEAVLRRL
                     TALYGTDTSQWRQVAVYTVEGALPAMVPPWPLSRTTRLTAGRYVCGDHRATGSVQGALA
                     SGSRAARELLGDPASG"
     gene            complement(20772..21764)
                     /locus_tag="BM536_RS08540"
                     /old_locus_tag="BM536_008480"
     CDS             complement(20772..21764)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019521840.1"
                     /locus_tag="BM536_RS08540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_008480"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_073492278.1"
                     /transl_table=11
                     /translation="MDEGDGGGAEVRRGGGMSTGEVARRLGVAPTTVRSWDRRYGLGPA
                     AHTGGRHRRWTAADLARLERMCALTATGLPPAEAARLALDETGSATPPREEDSAPVPRS
                     VARSRSRAGTGLRLGDVRQECKGVARAALRLDATALDGLLEDAIGQHGLIAAWTEVIMP
                     TLQAVGRKWESSGERYVEVEHFLSWHVSGALRRHSPPVPTDRPGATTVLACVPAENHTL
                     PLEVLAAALTERNLPIRMFGGSLPVESLVAAVRRTGPAAVCLWAQSRTTASRPLAQHIA
                     AIEWGVRGARRKPVVLTLGPGWAGQTTPGLPHPPGLAEAVAAVESAVRR"
     misc_feature    21817..21831
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.22"
                     /tool="antismash"
     gene            21928..22539
                     /locus_tag="BM536_RS08545"
                     /old_locus_tag="BM536_008485"
     CDS             21928..22539
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324498.1"
                     /locus_tag="BM536_RS08545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_008485"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_073492276.1"
                     /transl_table=11
                     /translation="MTTNARHTGVRTPATQEARHEEELARGLLAADENAFAAVYRRWGS
                     LVHTMATRSLGDTFEAEDVTQQVFLGAWRGRNGYRPEKGPLGGWLVGITRRKIVDALAA
                     RTRRLTLIDTVTHDADGRRHDVGATTDGVLDRVLLVDALSRLPHGQREVLCLGFYQDLT
                     QAQIAERTGMPLGTVKSHTRRGLHRLREAVEQGRAEENTA"
     gene            24789..25478
                     /locus_tag="BM536_RS43930"
                     /old_locus_tag="BM536_008495"
     CDS             24789..25478
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012363.4"
                     /locus_tag="BM536_RS43930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_008495"
                     /product="carboxylesterase family protein"
                     /protein_id="WP_211362849.1"
                     /transl_table=11
                     /translation="MSGPLARLSTTCRRRWLSPRRLVVPAVALLLSATAMTSAPAAAAE
                     GPIVTTRYGQVQGKVGETATSYLGIPYAAPPTGPLRWRPPVPPARWSGIRDARTPGNPC
                     VQRVQSSPWGDLAGPGTPSEDCLYLNVYTPAQRSLQKRPVMVWIHGGGFTVGSGTFYDG
                     GNLAAKGDVVVVNLNYRLGAFGYLAHPSLAKESAQGISGTTACSTSRPPCAGCRTTSWR
                     SAATPTT"
     gene            25433..26380
                     /locus_tag="BM536_RS43935"
                     /old_locus_tag="BM536_008500"
     CDS             25433..26380
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012363.4"
                     /locus_tag="BM536_RS43935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_008500"
                     /product="carboxylesterase family protein"
                     /protein_id="WP_211362850.1"
                     /transl_table=11
                     /translation="MQDNIVAFGGDPDNVTIFGESAGGGSVCQNLVSPRTTGLFDRAIA
                     QSGCGFPLPTQESQQNNGQAWADSLGCADAACLRTRTAQELLTASAAPTARWTPNVDGK
                     VLPLQVPAALDIGRFHRVPVLQGTTADEGRLTVATTYDLAGRQLTAAGYPVAVRALHGE
                     RADEILARYPLSDYGTPAEALGAVLTDSQFACLQSRTASLMAEHTRSYQYEFADRHAMD
                     YLNMPISFPIGAPHGSEIRYVFGSVSGTPAQNALSDSMLGYWTNFARTGVPYAAKAPRW
                     DLFPKVQVLAPEAITSVLTFPADHKCDLWSPATA"
     gene            26564..27304
                     /locus_tag="BM536_RS08570"
                     /old_locus_tag="BM536_008510"
     CDS             26564..27304
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004992834.1"
                     /locus_tag="BM536_RS08570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_008510"
                     /product="VOC family protein"
                     /protein_id="WP_073492268.1"
                     /transl_table=11
                     /translation="MTLQLVQVNFKARDDSALGRFWAEVLGWGVSSEGPGVTNLEPVGF
                     DWPDPSAVCIDLVRVPDPETVKYRVHIELATTSDAHQAELVARLKELGAKPADVGQGDT
                     PWTVMADPEGNVFSVLEPRELYQDTGPIAAVVVACADPRAMVRFWGEAIDWTVHELTDD
                     RALLRSVKGVGPYLEFRRTPDDEVVWNRLHLDVMSDPVEDQAREVARLQSLGAVRADVG
                     QGDDVSWVVLADPEGNEFCVLGRG"
     gene            complement(27431..28069)
                     /locus_tag="BM536_RS08575"
                     /old_locus_tag="BM536_008515"
     CDS             complement(27431..28069)
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019846.4"
                     /locus_tag="BM536_RS08575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_008515"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_342748794.1"
                     /transl_table=11
                     /translation="MVMAYAGHPVRTALGIGAGTGKATRPFARRGIVVTATDPDESMLA
                     ELRKHVPAGVRTAHAAFEDLRPGERYGLVHAAAALHWTNPEGRWTRMAALLEPGGVFAS
                     CGGRSDRPTPLWRKLSARREQHSWRATRFRPRTGHLRTTRCSGRGRSRNGPGGSRAFNG
                     PAAAGLVPEIVLVSLPSVRIGRPVRRRSMASHRACCGRTGYRSLRPVTP"
ORIGIN
        1 ggcatcacca ctctgcgctc accccggatg cgcgtgacga tccggctcga cggcgcgccg
       61 gccctgcgcc gtaccgcccg catggtcctc ctcgccaacg tcggctccgt gcagggcggt
      121 ctcacgctcg tgcccgccgc ccggcccgac gacggacggc tcgacctgct ggtcctcgac
      181 ccgcgcggac ccggtggctg gatccgcgct ctcggagcgc tgctgcgtgg cggcgcgagg
      241 acagcgcggt ccacgtccgc ggacaccctc gccgccgacg acaccggtac cggcgtcccg
      301 gtggagttct tcaccttccg gcgcgccgag ttcaccttcg agacccagca gttgcgcgaa
      361 ctcgacgggg atccggtcgc tccgggccgg cgcctcaccg cggaggtccg tccgggcgcg
      421 ctgacgatgc tgctgccgtc cggggacggg tgatgggtac ggcgaccgag ttccccgagg
      481 ccagggacat gaccggcgag gaactctgcc ccggcgaggc gctggtggcc ctgtgccgtt
      541 acggccgccg gccgctgccg cgcgacgtct tcgtacgttt gcgccacgcc gacggcttca
      601 caccctcccg cgcgctcgcc ctgcacactg tgctctcggt gctctcgatg ctctcggtga
      661 cgcggtacgg agccacacgg catgccgtcg acggccgcac ggtgccggcg gggatcccgc
      721 cggcgatcgc cttcgtcggg ctgcccaccg ccccgcaccc cgaggacatc ggcagactcg
      781 ccgagttggc gatccaccgg ccgacaacgt cggcccgccg ctcggcgcgg agttcatcgt
      841 gatggcggcc ggggccgatc tggcctccgt cgccctgttc ctcggactgt ccgccttcga
      901 gcagttgaaa gccgtgcggg tcatgcgccc cggcccgacc cgcaccgacc cgggagtctg
      961 aatgccccta cggttcacca cgcgccgttc ccgcgagcgt cgccgccggg aggccgacca
     1021 caggttcggc gtgcgtctgc tcggcgcggc cgtcgtggcc gcgctcgcgg cggtggcgtt
     1081 cggcctgctg gtggtccttg tcgaaggccg gtggcagccg ctgcgccgac tggacgcgag
     1141 cgcggcgcgg cgactgaacg agaccgcgct ggaccacccg gcctggaccg gcacgctgcg
     1201 tctcctgtcc gactgggtct gggatccggt gaccctgcgc gtcgtggtcg cgctgctcac
     1261 cctctggctg ctgcgccgcg gggcgtggcg gctcgccgcc tggtccgccg tgacggcggt
     1321 ggccggcggg ctgatcgggg tgctcgtcaa ggtggtcgtc gagcgggcca ggcccacctt
     1381 ggaggacccg gtggcgcacg cgccgggcta ctcgttcccc tcgggccacg ccatgacggc
     1441 caccacgtcg ttcgcgatcc tgctgctggt cctgctgccc atagtgccgc gcgcgtggcg
     1501 ggcggggtgc tggtgtttcg cggtgctctc ggtgctcggt gtcggcttca cccgcgtcgc
     1561 gttgggcgtg cactggttca gcgacgtggt ggggggctgg ctcctcggtc tcgtcgtcgt
     1621 cgccctcacg gccggggcct tcgaggcgtg gcgcgctgac atcggccgtc gcaccaccga
     1681 gctggccgac ggcctggaac ccgaactgtc cggcccgcac cccgagccct ccgtgttgtc
     1741 cgcgccgaca cggaggcgtt ccgcgcccgt gcctggcggt caccgcgcag gcggtccagc
     1801 ctcgggcgcg agggtgttcc gacgccacag gtgatccgcg cgatcacccg gctgtcctcg
     1861 ccgcggcgca cctgaagcga tctcgacacc gtggtgaggg tgtcgacggg cgaggtcgat
     1921 gtgcggttcc gctcctggca ctcacgtcag gaattgcagc caaggactgc aaccccgtgc
     1981 ggtcgatctc cggaagaggt ggtggcgtgg tgctgacggc tccgcgcatg atcacgtgta
     2041 atattactca atcattaaga tactttgtca gtgacttagt tgaccacgag gatgctcgga
     2101 gtacccatga gaaccacccc gcgctgggcc cggtggctcg tcccgctcgt actgctcgtc
     2161 gcatggctcg gagtcggagg cactctcggg ccgtacgccg gcaagctcgg cgaggtggcc
     2221 accaacgacc aggccgcctt cctgccacag agcgcggagt ccacgaaggt cctcaaggcc
     2281 cgcgaggcgt tcgaccagtc cgaaaccctg cccgccatcg tcgtatggac ggcggacgac
     2341 ggccgcgtca ccgaagcgca gcggtcttcg gccacccgcg cgatcgacgg cctcgccgga
     2401 cggtccggag tggtcggcgc cccctcgccc gctcttccct ccgaggacgg caaggcgttg
     2461 caggcggtcg tccagctgga gcccgatctc ggcgacggac taccggacgt cttgagcgag
     2521 gtgcgtgagg ccgctcggag cgtgccgggc gccaccgcgc agatcgccgg cccggcggcg
     2581 agtcaggcag atctgtcgga cgccttcgcg ggcatcgacg gactgctgct cggagtggcg
     2641 ctcgccgccg ttctgctgat cctgctgctg gtctaccgga gcatcctgct gccgttcctg
     2701 atcatcctcg ggtccgtgtt cgctctcggt ctggcgtgcg gaatcgtcta cgtcctggcc
     2761 gatcacgacg tggtccgcgt ggacgggcag gtacaaggca tcctctccat cctcgtcatc
     2821 ggcgccgcga cggactacgc gctgctcctg gccgcgcggt tccgtgagga actggtcctg
     2881 cgggaggacc cgtcatcggc cgcgctggcc gccgtacgcc ggtcgttcgg cgcgatcgcc
     2941 gcgagcgcgg ccaccgtggc cctcgcgctg ctggctctcc tcgcgagcga cctcacgaac
     3001 aaccgtgcgc tcggaccggt cggtgccatc ggcatcgtgt gcgcggcgct ctccagcctg
     3061 accttcctgc ccgccgtgct ggccctgctg ggcaggtcgg cgtactggcc gtcccggccg
     3121 aaggcttccg acgcgtccga ccggggacac ggggtgtggc gtcgcgtcgc cgcgctcgtc
     3181 gcctcccggc cgcgacgcat ctgggtggtg accgcgctcg gcctcgccgt cttcgccgcc
     3241 ttctccccct cgctgtcggc gaagggtgtg cctctcgacg agatcttcgt gaacgacgcg
     3301 ccctcggtcg ccgcccagca gacgctcggg gagcacttcc ccggcggctc aggcaatccc
     3361 gccgtcatca tcgccgacgc cgaccgcacc gcccaggtga cggcagccgc cagggagacc
     3421 gagggggtgg catcggccga cgcggtctcc gcgtcgggac ggccgggggc gcgcgagcca
     3481 ctggtggccg atggacgtgt ccgcatcgac gccaccctcg aggcctcggc ggacagcgac
     3541 ggcgccaagc agaccgtgga gcgcctgcgt gcgaacctgc acgcggtgcc cggagccgac
     3601 gcactcgtcg gcgggtacac ggcgcagcag tacgacaccc agcagacggc tgcccgggac
     3661 cgtacgctca tcgtgccggt cgtgctcgtc atcatcctgg tgatcctcgt actgttgctg
     3721 cgctccctgc tcgtaccact cctgctggta gcgaccgtcg ccctcaactt cctggcgact
     3781 ctcggagtgt cggccctggt cttcgagcac ctcctcggct tcagcggcac ggacgcctcc
     3841 gtgcccctgt acggcttcgt gttcctggtc gccctcggcg tggactacaa catcttcctc
     3901 atgtcccggg tacgggagga ggcgctcgca cacggcaatc ggcagggcgt gctgcgcgga
     3961 ctgaccacga ccggaggagt gatcacctcg gccggcgtgg tactcgccgc aaccttcgcg
     4021 gccctgatgg tgatcccgct ggccttcctc gtccagatcg cgttcatcgt ggcgttcgga
     4081 gtcctgctcg acaccctcgt ggtccgttca ctcctggtcc cggcgctggt gctcgacatc
     4141 ggtcccaggg cctggtggcc cagccacctg gcgcacgagg acaccggaca cgccactggg
     4201 cagcagccgt cgacgtgaga gctgccggca cacccacggc gtcgacggtg ctcacggtga
     4261 gcaggacgac cgtcgccgcg gggaaggggc cgtcggacgc gggtcggcga gagtcgtcga
     4321 tggtggcgag agaacggaca gggcccgtcg accgactccc cgtcccgggt acgaggtgac
     4381 cttcctgagg ccggtcctcg gtccccggct gtcggcggac ctttcgcctc gcctgcggcg
     4441 cacgtccgtg gtgcgatgaa acagggggtc gggaaggaga gagcgatgat cccaccggca
     4501 gaggagcgca agaggggcac gggccccgtg tcggtccgcc cgctgggtga ggcggacctg
     4561 gatcgggccg acgagatctt cagggtcgcc ttcgggacgt tcctcggggc tcccgagccg
     4621 aagacgttct tcgggaccgc cgactacgtt cgcactcgct gggcggccga tccccacgcg
     4681 gccttcgcag cgacggtcga gggcgaggtc gtcgcgtcga acttcgccgt caactggggc
     4741 agcgtcgggt acttcggccc gctgaccgta catccggacc tgtgggacca gggcatcggc
     4801 aggcgcctca tggagccggt catggaatgc ttcgggacct gggggaaccg acacctgggc
     4861 ctgttcacct tctcgcacag tgcgaagcac ctcgagctct accgccggta cggcttctgg
     4921 ccccggttcc tcacagccat catgaagaag cagatcgcgg gcagtacggc ggtccccggc
     4981 cgagcgctgt acggcgaact tcccgccgcc gagcggctcg acgccctgag cctctgtcgc
     5041 acactgaccg gggccgtctt cgagggcttg gacgtggaac gcgagatcgt ggccacgcac
     5101 gcgcagggac tcggtgacac catcctgctc cagggggccg gctccgacct cgacggcctg
     5161 gccgtctgcc actgcggacc cgggtcggag gccggagagg acgtgtgctt cgtcaagttc
     5221 ggcgccgtgc gcccgggccc ggaggcggcc gaccggttcg aacgactgct caccgcgtgc
     5281 gagcggctcg ccgccgagcg cggcctgggc caactggacg ccggaatgaa cctggcccgc
     5341 caggatgcct accggcgaat ggtcgaccgc ggtttccgca cctggttgca gggcgtggcc
     5401 atgcacaggc ccaacgaacc cggctacagc caccccgacg cctacgtgat cgacgactgg
     5461 cgctgagacc gcgccgcact cgtcccacga ggaaggcccg gtgctgcccg aacccgtgca
     5521 cctttcgcgt cggcgccgac ggccggacac ctcccggccc actgccgaag tgctgtcctc
     5581 gctcatggac atagccggca tggacgtagt cggcatggac gtagtcggcg ggtcaagcgc
     5641 tcgccgccgg cggtccgtga gtgctcggag ggtcggcgtc acggacgacc gggggcaccg
     5701 ccgggtaacg cgcggacatc cgcgcggagc gggccggcgt ccgtggtgct cgccaacgcg
     5761 ggtgcggccg agggcggccc gttggccgag tccgatcccg cggtgtggcg ccgcgtgcga
     5821 agtgaaccag gtggtgccag tggcctcgcc tcgggtcgtg cacgatgcgg ttcgcccgtg
     5881 cggagcagtc ggatccacgt ttgcgaccac gcggttgtcc cgcctgcgct ccgccaccca
     5941 gcggcagcgg cagtccgtgc cggcccgaaa cccgaggtcc cataggcgcg ggcaccgcag
     6001 ggacgtccag ctggcgtacc acgcaacccc tcgcaccccg ttcttccgcc cgcccggtca
     6061 cccgtccggc ccgcccgctc ccgcggtacc gaaggccggg agacggacgg ccctggccct
     6121 gctggactgc ggactcacag cgggcccccg tggcccgagt cggcgtcggc ctcccggcgc
     6181 cggtaccggc gccgggaacc cgacggaagg tggcggccga gccgaacggc ctccgcctcc
     6241 ccgtcacggt cgccgaccac gagggcgcga caggcacggt cgcactgcag cagccatgat
     6301 cggacggacg agcgggttgg accgcccacg cggaaggagc actcgtggca gccactgatg
     6361 gacagcggaa cggcgaacgg ctgcgctgcc tggtcaccgg ggcctccggg tacatcggcg
     6421 gacggctggt gcctgaactg ctccaggccg gtcaccgggt ccggtgtctg gcccgctccc
     6481 ccggcaagct ccgcgaccat ccctgggccc aggacgccga aaccgtccgc ggcgacgtca
     6541 cggacgccgc ctccgtcgcc aaggccatgc gcggtgtcga cgtcgcctac tacctcgtgc
     6601 acgcactcgg aaccggctcc accttcgagg acaccgaccg ccgcgccgcc cggatcttcg
     6661 ccgagcaggc gcacgccgcc ggagtacgac ggatcgtcta cctcggcgga ctcaccccga
     6721 aaggggtgtc cgagcgctcc ctttcccctc atctgcgctc cagggcggag gtcgggcgca
     6781 tcttcctcga cgccccggtg cccgccacgg tgctgcgggc ggccatcgtc atcggctccg
     6841 ggtcggcgtc gttcgagatg ctgcgctatc tcaccgagcg gctgcccgtg atggtgaccc
     6901 ccagttgggt gcacacacgg acgcagccga tcggggtcca cgacgtcctg cgctacctcg
     6961 tcggctcggc caccatgccg cccgacgtcg accgggcctt cgacgtcggc ggaccggacg
     7021 ttctgaccta ccgggagatg atgcgccgct acgccgtcat cgcgggactg cggcggcggc
     7081 tcatcgtgcc ggtaccggtc ctcaccccgc ggctgtcgag ccactgggtc ggcctcgtca
     7141 ccccggtgcc cgcgtccatc gcccggccgc tgaccgaatc cctgcgccac gaggtcgtgt
     7201 gccacgaaca cgacatcgcc cggtacctgc ccgatcctcc gggccggccg ctgcccttcg
     7261 acgaggccct cgccctggcc ctgcgcaggg ttcgggacgt ccaggtagcc gcccgctggt
     7321 cgtccgacgt cgcgcccggc gcccccagcg acccgctgcc caccgacccc gactgggccg
     7381 gcggcagcct ctacgaggac gaccggcacc tgccggtcga cgcgtcccgc gcgtcgctgt
     7441 ggaaggtcgt cgaaggcatc ggcggcgaca acggctggta ctccttccct ctcgcctggg
     7501 cggtccgggg ctggctcgac cggttcgtcg gcggagtcgg tccgcgccgc ggacgacgcg
     7561 acgccgagcg cctgcgggtc ggtgacccgc tggacttctg gcgggtcgag gagatcgagc
     7621 cgggccgtct gctgcggctg cgtgccgaga tgcgactgcc cggactcgcc tggctggaga
     7681 tgtacgtcga aacggacacc gccggccgaa cccggtaccg ccagcgcaca ctgttccatc
     7741 cacgcggact gctcggccac gcctattggt ggggtgtcgc accgttccac gccgtcgtct
     7801 tcggcggtat ggcccgcaac atcgcgcagg ccgccgccaa aggcacgagg gcacccggac
     7861 gtgcaccgcg caccgaccgc accgggcacg cccggttcgt caggatcatt cgtcgctagg
     7921 ccgcacgcaa ccgtctcacc ctctcaggag cgacgacatg acccgcgcgg tcgtcctgtt
     7981 cacctcggat cttcgcccgc acgaccatcc gacgccgcgc cccgtaccca cggcggccga
     8041 cgcggaggtc gccccccacg tccgcgcccc cggcgtacac accgcgggct tcgacgcacc
     8101 cagccgcgac atcttcccca ccgactgcct gctcgacccg gccgccgcgc cgcgacgaca
     8161 cgggatccgc aacccggtcg ttcagcgcaa acgccgcgac ccgtacggaa cttcgtgcgc
     8221 agttgggcac ccgaaccgct cgtggaggac cggttcctcc acgagccccg gcgcgcccgc
     8281 ctcgaccacc cccaacctgt gctcgacctc tccgacgggc cggcgcgccc cgcgcacgcc
     8341 cgcggtcgct actgagaagg gacacgccgt gcactggctc ttcggcgacc agctcggtcc
     8401 tcacttcctc acccccggcg acggcggccc cggccgcgac accccgctgc tcatgatcga
     8461 ggcgcgttcg gtgttccgcc gccgccgctt ccaccgggcc aaggcacacc tgatcctctc
     8521 cgccatgcgc caccgggcgg ccgaactggg cgaacggatg acctacgtgc gggccgacac
     8581 ctaccggcaa gggcttgaag aggccgccgg cgaccgtccg gtcaccgtgc accacccgac
     8641 ctcgtacgcg gcactgcggc tggtccgctc actcccccag gtcaccctga gtcccgcacg
     8701 gggcttcctg gtgccgatgg acgacttcgc ggcgtgggcc gacggacagg gcggcgagcg
     8761 gctgcggcag gaggacttct accggtgggt gcgcaaaggc cacgacctcc tgatggacgg
     8821 cgacgccccg gccggcgacc ggtggaacct ggaccacgac aaccggcagc ccccaccgcg
     8881 cgcagcctcc acgctccagg ttcccgcacc gttccggccg cgggaggacg agatcgacga
     8941 cgaggtccgc cacgacctgg accgctggga gagggacggg gacgtcgcct tcgtcggacg
     9001 ggacgcaccg cgcgcgttcc cggcgagtcg cgccgaggct cgggccgccc tcaaacgctt
     9061 cctcacccac cgcctcccca cgttcggccc ctacgaggac gccgtgctcg ccgccgaccc
     9121 ggtgatgagc cacagcctgc tgtcgtcctc gctcaacctc ggcctgctcg acccggccga
     9181 gtgcgtcgag cgcgcggagg cggagtggcg cgccggccgg gctcctctca acagcgtgga
     9241 ggggttcgtc cggcagatcg ccggctggcg cgagtacgtg tggcagctct actggtactt
     9301 cggcgaggac taccggcgct ccaacgtcct gcgccacacc gccgcgctgc cgcactggtg
     9361 gagcgagctg gacgcggacg cggtggaggc gcggtgcctg cgcacggtgc tgtcccaggt
     9421 gcgcgacacg ggctggaccc accacatccc tcggctgatg atcctcggca gttacgcact
     9481 tcagcgcggc tgggaccccg ccgcggtcac ggactggttc caccgctgct tcgtggacgg
     9541 atacgactgg gtgatggtgc ccaacgtcgt cggcatgtcc cagtacgccg acggcggccg
     9601 gatgacgacc aagccgtaca cgtcgggcgg cgcctacgta caccgtatga gcgatctgtg
     9661 cggaccgtgc cgctaccggc cgggggaccg gaccggggag caggcctgcc cctacacggc
     9721 cggttactgg gccttcctcg acaggcaccg ggaccggctc ggccgcaacc atcgcaccgc
     9781 ccgaccggtg caccagctcg gtcggctgac cgatctcccc gaggtacgcc gccaggagcg
     9841 cgacagaggt gacgcaccgc catgacgagg cggaggttgg gccgatggag tgggcgtcag
     9901 cgggacgacc cgccaaccgg gcaggaatca gcgcatccgt acagggccac tccgccgaag
     9961 caacggtgtg cagatgaccg ggagtgagaa ggagttgcgc atgctgggac tgcggcccac
    10021 ggtggccgaa ccggtcgggc gggccgacgg tccgctcacg gcccgcgagg gggcccgggc
    10081 cgccgaggcg gaactcgggc gcgtcctcga cgatgtgctg ggacgcgccc gcgaggcgga
    10141 cccggtgttc gcccgtgaca tcgccgaccg cgtcgcctcg ttggtcctgc gcggcgggaa
    10201 gcggctgcgc acggcgttcg cgtggtgcgg atggcgggcc gccggcggaa ccggggatgc
    10261 gacgccggtc ctgcgcaccg gtgcggccct cgaactcgtc caggcctgcg ccctcatcca
    10321 cgacgacctg atggacggat caccactgcg tcgcggcgcg ccggcggtac acgtggacct
    10381 cgcccgcatg catgagaccg cacgcatgac gggctcaccc gaaacgttcg cgacctccgc
    10441 ggcggtcctc gccggcgacc tcgccctggc ctgggcggac gacctgatga cggagacggt
    10501 gctcggctcg ccgcacggcc cacaactgca ccgcgagtgg caggccatgc gcaccgagat
    10561 ggtcgccgga cagtaccggg acatccacgc gcaggccacc ggcgcgtccg gcgtcgacga
    10621 ggcggtgacc atcgccaccc tcaagagcgc cctgtacacg gtggagcgtc cgctggcgct
    10681 gggcgcgtcc ctggccggcg ccgatgccac cgtcctggac gcgctgcgct ccgccggacg
    10741 gtgcgccggc ctcgcgttcc agctccgcga cgacatcctc ggtgccttcg gcgacccggc
    10801 cgagacgggc aagtcgtccg aggacgacct ccgcacgcgc aagctcacct atctgctcgc
    10861 cgtcggctcc cggctcgccg aggcctccgg tgaccgggaa gccgcggacg tactggcccc
    10921 gggtgcgccg tccgtgtccg acgacaccgt gcgccgcatg cgggcggcac tggagcgcac
    10981 gggggcgcgg gccgtcgtcg agtcgaaggt caccgagctg gccgcgacga gcctgcggca
    11041 cttcgaccgg accggcgcgg agccatcggt gcggcgcgag ttcgccgcgc tggtcggacg
    11101 agcgtccgga atggcgcccc accgcacggg ggaggccgcg tgaggacggt agcgggtccc
    11161 acggaccacg tggtcgtggt gggcgccggc ctgtccggcc tcgcctgcgc gctgcacctt
    11221 ctgggcgccg gtcgccgagt gacggtcgtc gaacgggacg acggccccgg cggccgggcg
    11281 ggccgcgtac gcctgggcgg ctacgagatc gacaccggac ccaccgtcct caccatgccg
    11341 cacctggccg acgaagcctt cgccgccgtg ggcgacagcc tcgaccgcca cgtcgagctg
    11401 acggccctgc accccgcgta ccgggcctgt ttcgcagacg gcagctccct cgacgtgcac
    11461 accgacggcg aggcgatgga ggccgaggtc agacggttcg cgggcccggc ggaggcagcc
    11521 ggctaccgcg aactgcggga ctggctggag cggttgtacc gggcccagat gcggcggttc
    11581 atcgacacga acttcgactc tcccttccaa ctgctgcacc cggacctggc acgtctggcg
    11641 gcgctgggcg gattcggccg gctggaccgt cgtatcggcc gtttcctcgc cgacccccgg
    11701 ctgcgccggg tcttctcctt ccaggccctg tacgccggtg tggccccggc cagagccctc
    11761 gcggcctacg cggtgatcgc ctacatggac accgtggccg gcgtctggtt ccccaagggc
    11821 ggcatgcacg cgctgccgcg cgggatggcg aacgcggcgg cacagacggg cgccgagttc
    11881 cgctggtcgg ccgaggcgac catgctggaa cggtcggggg accgggtccg tgccgtgcgt
    11941 ctggcgtcgg gcgagagcat ccgttgtgac gccgtggtgc tgacgtgcga gctgcccgcc
    12001 gcgcaccggc tcctgggacg cgctccgaag cggccggtgc ggttgcgtca ctcaccgtcc
    12061 tcggtcgtcc tgcacgccgg aaccgaccgc acgtggcccg gtctggccca ccacacgctg
    12121 tctttcggcg ccgcctggga acgcaccttc gaccagctca cccgcacggg agagttgatg
    12181 agcgacccgt ccctgctgat cacccggccg accacgcacg accccggcct ggctccacca
    12241 ggcaggcacc tgcactacgt cctggcgccc tgcccgaaca ccgacgtggg accttccggg
    12301 gccgagtggc gtgatctggg gccgcgctac cgcgactgcc tggtcgccga gttggagcgc
    12361 cggggactcg acgggttcgc ggacagcgtc caggaggagc tgctggtgac gccgctggac
    12421 tggacggcgc agggacatgc cgcgggcagc cccttctcgg tctcgcacac cttcgcccag
    12481 accggcccgt tccgtccacg caacctggtg cgcggcctgg agaacgtcgt gctcgcgggc
    12541 tgcggcacca cccccggcgt cggggtgccg accgtgctca tcagcggcaa gctcgccgcc
    12601 ggccgcgtga ccggcggacg taccggcatc cgtcacgtgc acacgcgtcc ggcacggcgt
    12661 ggcacccgag ccgtcgcacc gaccgcggaa ggcgcccatg acccgtcgtg agctggacgc
    12721 cgcgggcatc accgaccccg ccctgcgtgc cgcctacacc gagtgccgac gactcaacgc
    12781 ccgtcacggc aagagctact tcctggccac ccgcctgctg ccggtggagc ggcggtccgc
    12841 cgtgcacgcc ctgtacggtt tcgcccgctg ggcggacgac atcgtggacg acctcgaccg
    12901 gcaccggaca ccccgggaac gcgaccgtcg gctgatgcgt ctggaggacg acctcgcacg
    12961 cgggctgcgc accgggacgg gggacgagcc ggtggtgcgg gccgtcgccg acaccgctga
    13021 acggtacgac atcgagcaca cgctgttcgc cgacttcctg gcctcgatgc gcagcgacct
    13081 gcacgtcacg gactatccca cctacgccga cctgcggacc tacatgcacg gctccgccgc
    13141 ggtgatgggg ctgcagatgc tgccggtact cggcacggtc gtcccccgtg aggaggcggc
    13201 gccgcacgcg gcggccctcg gggtggcctt ccagctcacc aacttcctgc gcgatgtcgg
    13261 cgaggacctg gaccgggggc gcgtctacct gccggccgac ctgctcgccg cccacggcgt
    13321 ggaccggccc atgctcgagt ggagccgccg cacgggccgc accgacccgc gcatccgcgc
    13381 ggcactcgtc gccgccgaag acctgacgcg gaaggtctac cgggcggcgg aacccggcat
    13441 cgccatgctc gacccgcgga cccgcccctg catccggacc gcgttcgccc tctacggcgg
    13501 catcctcgac gcgatcgcgg accaggggta cacggtgctg cagcgtcgtg cggtggtctc
    13561 ccgagtccgc cgcgcggcca cggcgacggc cggagtcgta cagatcgccg gcgcgcgatg
    13621 gcgtgccgtc cgcaccgacc gtcgggcgcc ccagccgggc gtcactccgc tgccgtggaa
    13681 gggacccgtg aagtgagtga ccgagcggac cggacccgtt ggacaccgcc gttgcggcgc
    13741 gccgccggtc ggactgggcg acccagacac cgacgtggcg cgaggcccgc ccggctctga
    13801 tcgccgacgc gctcgagcgg gcctccgccc gtccctccgg gaactggttc gtcgtcgggg
    13861 cctcccgtga cgttcgcgcc ggcggccgcc cctacggcag gacggtgggc ggtgtggagg
    13921 tcgtgctgtg gcggtcggac accggtgacc tgcgcgcggg cccgggcagc tgcccgcacc
    13981 tcggtgcgcc cctgcgggac agccgggtgg tgtgcggaac gctggtgtgc cactggcacg
    14041 gactggccct ggacgacggg gcgttcgcag gatggcgtcc gtacccggtt catgacgacg
    14101 gcgtgctggt gtgggtccgg ttggacgcgg tcggcggcga ggagccgtcc gagcgccccg
    14161 tggtgccggt gcggccggcg gcgcgcagcg gggtggacgc cgtcttcacg gccgtagggc
    14221 ggtgcgaacc ccaggacgtg gtcgccaatc ggctcgaccc gtggcacggg tcgtggttcc
    14281 acccgtactc gttcgtcgac ctgacggtgg cccggccacc acagggaccg gaggacgacg
    14341 tcttcgtcgt cgacgtctcc ttccgggtga ccgaccgtct ggtggtgccg gtgcgggcgg
    14401 agttcaccgc tcccgggcct cgtacggtgg tcatgcgcat cacggagggg gaagggtcca
    14461 cgtccgtggt cgagacccat gccacgccgg tgacgggcaa gtcggcccaa cggccgcgga
    14521 cggccgtcgt cgaggcggtc gtcgccgcct cggaccggcg cggcttcgcc ctggcgcggg
    14581 cggcggcgcc catgctgcgc ccgttgatgc gccggacagc aggcaggctg tggcgcgacg
    14641 acctcgcgta cgcggagcgg cgctgggagc tgcgcagcag cggtcagttc ccggggtgat
    14701 caccagagcg gcggagagag ggctccggcc tgcccggtcg ggggccggct ctcgttgtgg
    14761 gccgggatct gtgcccgagc gtgaggggtg gcccgccctc ccccgcttcg gctggagaag
    14821 cctgttcgcc ggcggcggca tgccgtcggc gggcagttcc ttgccggtgt cactccgctc
    14881 cccggccgtc ggtgttcggc ccgggtctcc ccggtttccg cgcgaacggg gcggagccgt
    14941 ctgcgggccc tgcgagctgt tcgcccctga gcgggagaac ggcgctcagc ggtttcccac
    15001 gcggctgagg gcgcgcagca ccgtcgaacg gccggcgcgg ggaaccgtcc acagcgtctg
    15061 tccgcgtact ccccagtccg cgagcagggc tccggccgcc aggaacccgg tggtggccgc
    15121 gcgttccatc aaggccacgg gcaggtcgct gcggatcgcg tccccggcca gtgtcaccct
    15181 cgggtgagga gtgagcacgg tgggccgtcg ggtgtgggac ccgaccggga agaagggaca
    15241 gtcggagcgc catgcgtgcc gggcgtccag gatccgtgct tgccgtgtct ccgggtacac
    15301 gcggtggagg ctgtcgatga ggcggttctg caccgtctgc ggtgcggacc ccgcggcgac
    15361 ggcgtaagcg tgcagttcca ccacggaacc gccgctgcgg gcggcccagc gtgcggcctc
    15421 cccctcgtag cggtcgagga cgctgatgtt gtcgaggccg tcgaagccgc tggtgccgag
    15481 gaatcccggg cggtcggcgc ggaccggccg gtcgagccag agccgggaga cgaggaaggg
    15541 cggggcggtc gtcagggagg cgatgtcgtc gcgccagacc ggagtgccga ggccgggtga
    15601 cgcggcgacc acctcacgca gcgctccggg gtcgagggcg aggaccgctg cttcgtaccg
    15661 gtccagggcg tcgtccgtcc gcacctccaa tcccccggcg tcgtcggggt ggacgccgcg
    15721 tacgggtgtg ccggtgcgga tgacggcgcc gaggctctgg aggtagtcac cgagcggctc
    15781 ccacagggcc tgggggaagg gctcgtccgg tacgtcgaag agcaacccct ccgccgagcc
    15841 cagaaagtag atgtggaaca tcagcagcag ttccgcggcg gacagttcgc gcgggtccgc
    15901 gaagaagctg cgggagaaca cctcgaaggc caggtggtgc gcggcttcgg ggaagcggac
    15961 gcgttccagg aacgccgtgg cgctcatgtc gtcgaagcgt tcgtaggcct cgggcacgcg
    16021 gacgtcgagg agcggcagtg ccgcccgggc gtccatgccg gcgaggtcgc gccagccgaa
    16081 ggtggggctg aggacgacga acccgagcgc gctgaacggt ggggtgcgcg ggacgcgtgc
    16141 gaagctgtcg gtcagtccgc cgctgtgccg tagcgggtag tcgggcagcg ggcggaggcg
    16201 gtcgagtccg ggatcggtgc gccgcagcag gccacgcagg ttgtagtact ggcggaagaa
    16261 ggcgtggaag ccgcggctca tggtcgcccg ggacccgtcg gagagacggg tgggccaacc
    16321 cgtgagacgt ccgccgagcg agtcctcgcg ttcgtagagg gtgacgcggg cgcctcgttc
    16381 ggccagcagg gtggcggcgg ccaggccggc gatgcccgcg ccgaccacgg cgaccgacgg
    16441 cgcgtcctcg cggtcgaatc ggtcgcggcc cggagcgggc atgatgatct ccgccttgcg
    16501 gtcgcgcccc cggcgggtgg cctgacggcg ggcgctcacc gggcgtcctc ggcgtatgga
    16561 gaggcgtcgt cgcgggaggc caggaaggtg tgcacgatgc cggtctgcca ccctgcgacg
    16621 ggcacggcgc gtacgccggt gaagccggcg tccgacagac gcgcggtgaa ggcgggcacg
    16681 gtgtcgaacg cgaggacgct gcgccacagg tgccggtaga gggcgcggtc gccgctcagt
    16741 gtgcccgcgg ggatgatcac ggcctggcac acggcagtcc acagggcgcg gtggacggcg
    16801 gagccgctga ggctgtactc gtgaacggcg agtcggccgc ccggtcgcag cagcgagcgg
    16861 acggctgcga ggacaccgtc cgggtcggtg acattgcgga acaggtaggc ggcgaacacc
    16921 gcgtcgtagg gcccttcccc cgtcgtcacc acttcttcgg cggtcaggtg ctggaaccgc
    16981 acctgagcgg gccactgctt ggccagcgcg cgccgcagca tcccggagga ggcgtcgacg
    17041 gccgtgatcc gggcgcgcgg cgcggcccgc aggagagctc tggtggacgc gccggtgccg
    17101 cagccgaggt ccagcacgtg cagaccggca ccggccctgg gcaacctcag gcgacgcgcc
    17161 gaacgcagca ggtcggtgcg gtagccgggg ttgagggccg tcaggcggtc gtaggtgtgc
    17221 gaggcgtggt cgaaggcgca tgccagttcg tggtcgcgca acagtgtcat cggtggtctt
    17281 ctccggtggg tggggccggc cgcgaacggc gtggcaggaa gggcagttcg acggcggtgc
    17341 gcagcatggg gcccacgggg gtgcgcaggc cgatgctcca ttcctcccag ggcgaggtgt
    17401 cgccgtcgag gaagcgcagg aggcgttcgg gcgggacgcg gcggaacagg tccgtgaaga
    17461 agtcggggcc gttgatccgt ccttcgtcca gggcccgcag cagcacggcg tccatggcga
    17521 gggcccgccg cccgtgtggc gggggcacga ccacgtggcc cgcgtgcaga gccgcggcga
    17581 tggcccggct ctgccgctgc acggcggcga aggtgtagcc ggtcgccggc cgggtggcac
    17641 cgcccgctgt cccgatccgg aagacggccg ggccgacctg acgggcgaag cgcgcgtcgg
    17701 tcatgggaat cgccccctgc tccgccgact cgaccgtgaa cgcgtcgagc cgcagaacgt
    17761 cgcggcagta gtgagccagc gccgtctcgt acgcctctgt ggtcagcgcg gtccgggaga
    17821 actcggtgta ctcgacgagg gcgcggtccg gcgccagggg cagtacgtag ccgaaggcga
    17881 ggccgtggcg cggttgcggt acccggaagt ccatcaggtc ggcgacttcg ggatcgaacc
    17941 ggtccgtccc cgtgtgcacg aaccagccgc ggaagtgctg caacagccgc gtccgggccg
    18001 gtggcagcgc gcgcctcggc cgggagtcga agacgtgtcg cgcccggagc cacagcgtcc
    18061 tgccgtcggg accggtgcag cgcacctcag cgccgtcggc cgtgttgcgc acgatgtcgg
    18121 ccgtcgcgcg caggacgcgt acgccggggg acgtgctgag ccggtgatgg accagccgtt
    18181 cgaagtccgt cgaccggagc atgcggtagg tcagcggcga cgggtggacg gtgatcgcgc
    18241 ggccgtcggt gccgtgcacg cgcagtctgg tccaggaggc gctgaccgct tcgtcgaggt
    18301 cggcggcgcc gcggtcccag tagcaccagg tccgttcagg agggcgcagc ggtccgtcgg
    18361 ggggctccac gagggtgacg gtgggtgaga aggacgcggt cagccggtgg gcgaggctga
    18421 gtccggccgc gccaccgccg acgatgacca cgtcgcacgg ccctccggat gcggggggtt
    18481 gtcggctcac ctggcgcgcc gttcgaccac gggtgtgccg tccggggcgg tgaacagcag
    18541 ttcggcgtcc gtctccatcg cgtcggcgag ggccgccacg acacggtgcg gatcgcctcc
    18601 ggccggcatc ggtggggcgg tgcccgcgac ggggcggtcg gcgaagcccg tgtccaggtg
    18661 tccgggcctg gcctccagga cacggatgcc gttggtccgt acctcgcggc gcaccgcgcc
    18721 gagccaggcg ctcagcgccg ccttggacgc gctgtaatcg gccatgcccg cctgcgggtg
    18781 ttccgcgacc acgccggtga acgcggcgat cacggaaccg gggcccatga cggtgagcgc
    18841 ggcgcggaag agggcggcgg gcgcgaggac gttgaccgcg tacaggtgct ccgcgacctc
    18901 gtcacccacc tccgccgccc gtccgaaggc caccgcgccg aaggccgcca ccacggcgtc
    18961 cagcccgccc agagccgcct tggcgtcgtg caccgcgcgg gcacaggacg cggggtcgta
    19021 cgcgtcgaac agcacggtcg gagcccccgg acacgcctgg gcgacctgag cgagacgggc
    19081 cggatcgcgt cccgcgagcg cgggacacgc tccacggccc gccagctcgg cggtgagcgc
    19141 accgccgagg acaccggtgg cgccggccac caacacgcgc gcgccgctga ggtccacact
    19201 cttctcccac tcgcaggaag gtcaccggct ctctgcctcc atcgtctgtt ccgtgcggcg
    19261 accgcgtccg gatgcagctc ccgcgatccg ctcggctctc acccggacgc cggatcaccg
    19321 agcagttccc gggcagcccg gctgcccgag gccaacgcgc cctgcacgct gccggtcgcc
    19381 cggtggtccc cgcagacgta ccggcccgcc gtcagacgcg tggtacggct cagcggccac
    19441 ggcggcacca tggcgggcag agccccctcg acggtgtaga cggcgacctg ccgccattgg
    19501 ctcgtgtcgg tgccgtagag cgcggtcagg cgccgcagca ccgcttcgcc cgccccgggg
    19561 cggtcccctc ccagcacgga cgtggcgatc agcgcggtac ccggcggcgc gtacgtggac
    19621 gtcacctcgg tcagcacgca ggtgttgagt acgtcgccgg agctgtccac catcagggtg
    19681 ggttcgctca acggtgggct cgcggctgcg tggtagtagg tggtgaccgt ccggccggcg
    19741 ggagcgtcca gcccggggag cagacgtgct gcggtggccg cgtccgtcgc caccacgacg
    19801 gacgcggccg gcagctcacg gccgtccgtc agaagcactc cttcgggggt gagcatgtcg
    19861 acgggcgtct ccagccgcag aacgccctcg ggcagaccgt ccgccaactg ggcgggcacg
    19921 gcgccgactc cgtgggcagg cagacagagc gtccccctga ccatgctccg ccagaccagg
    19981 tggaagaagc gggcggaggt ctccagccgg tcctccagga acaccccgga cagaaagggc
    20041 ctcaagatct cggagaccgt tcgttccgac agaccggctc gcgagagggc cgcggcggtg
    20101 gacctgtccg ggccgtgctt gaggagggcg gcgggcagga gggcgtccct cgccgtgagc
    20161 gcgcccatgg ccgccaggtc cccggccggc aggacacgtc ccggtagcag tgatctcgcc
    20221 gcccgcggct gccgggtcgg atcggccagg cgtacgtctc ccgtcgaggt acgcgcgatg
    20281 atgcccggcg tgaagggcct caactgcagg ttccggaggt tcaaacgacg ctttacctgc
    20341 ggatacgagg tattgaacac ctgaaagccg cggtccagca ggaagccgtc cctgcggtcc
    20401 gttctcatcc ggccgcccac accgtcggac gcctcgagca gcgccacgct ccgcccggca
    20461 cggcacaggt ccagcgcgca ggcgagaccg gcgaggcccg ctccgacgac gacggtgtcg
    20521 ggggtgccgc gttgttgact gctcatgttc ccttttcctt cggcgccggc cttcgcggag
    20581 cgagaggcgg ggtggactcg ctgagggtcc tgcgctgctc gtcgcacagc actcggcccg
    20641 gcacggggtg ccctcgttgg tgccgcgtcg ttccaggagc gcagaacgcc tgctcacgtg
    20701 tccacccgaa cacgttctgc ccggggaggg cgggcgccac gacctgtgcg tacccgatga
    20761 gcggcgtcac ctcacctgcg cacggcggac tcgaccgcgg cgacggcctc cgccagcccg
    20821 ggagggtgcg gcaatcccgg tgtggtctgc ccggcccagc ccgggccgag cgtgaggacg
    20881 accggcttcc tgcgggcccc gcgcacaccc cactcgatcg ccgcgatgtg ctgggccagt
    20941 ggccggctgg cggtggtacg ggactgcgcc cacaggcaca ccgcggccgg tccggtcctg
    21001 cgcaccgcgg ccacgaggga ctccacgggc aacgagccgc cgaacatacg tatgggcagg
    21061 ttccgttcgg tcaacgcggc ggccagcacc tcgaggggca gggtgtggtt ctccgcgggc
    21121 acgcaggcga gcactgtggt ggcaccgggc cggtcggtcg gcacgggagg cgagtggcgc
    21181 cgcagcgcgc cggagacgtg ccaggacagg aagtgctcga cctcgacgta ccgctccccc
    21241 gagctctccc acttacggcc gaccgcctgc agcgtcggca tgatcacctc cgtccaggcc
    21301 gcgatcaggc cgtgttgccc gatcgcgtcc tccagcagcc cgtcgagggc ggtggcgtcg
    21361 aggcgcaggg ctgcgcgggc gacccccttg cactcctggc gcacgtcgcc gaggcgcaga
    21421 cccgttccgg cccggctgcg cgaacgggcc accgaccgcg ggacaggcgc gctgtcctct
    21481 tctcgtgggg gcgtggcgga acccgtctcg tcgagggcca gtcgggcggc ctcggccggt
    21541 ggcaggccgg ttgccgtcag agcgcacatc cgctccagcc gagccaggtc ggcggcggtc
    21601 cagcggcggt gccggccacc ggtgtgcgcg gcggggccga gtccgtagcg gcggtcccat
    21661 gaacggaccg tcgtcggcgc cacacccaga cgcctcgcca cctcgccggt ggacatcccg
    21721 ccaccgcgtc gcacttccgc cccgccaccg tcgccctcgt ccatgtccac cctccgacct
    21781 tacgacgcac aagcgacgca tgttgtctgc gtcgtttccc ttcagaaaac tggcacgcga
    21841 gccgacaacc ggagcacacg ccgttccggc ccgctccacg ggcggccttc cgccacgcac
    21901 agcacggacg gcaggaggaa caagggcatg accacgaacg cgcgacacac cggcgtccgc
    21961 actcccgcca cgcaggaggc ccggcacgag gaggaactcg cccgtggtct gctcgccgcc
    22021 gacgagaacg cgttcgcagc cgtgtaccgg cgttggggct cgctcgtcca caccatggcc
    22081 acgcgttcac tcggtgacac gttcgaggcc gaggacgtga cccagcaggt gttcctcggc
    22141 gcctggcgcg gacggaacgg ctaccgcccg gagaaggggc cgctcggcgg ttggctcgtc
    22201 ggtatcaccc gccgcaagat cgtcgacgcg ctcgccgccc ggacgaggcg cctcaccctg
    22261 atcgacaccg tcacccacga cgccgacggg cggcgacacg acgtaggcgc gacgacggac
    22321 ggggtcctcg accgcgtact cctggtcgac gcgctgtccc ggctcccgca cggccagcgg
    22381 gaggtgctgt gcctgggctt ctaccaggac ctcacccagg ctcagatcgc cgaacgcacc
    22441 ggtatgcccc tgggcacggt gaagagccat acccgacgtg gccttcaccg actgcgcgag
    22501 gcagtcgaac agggccgcgc cgaggagaac acggcgtagg cgtaggcgcc cttcgattcg
    22561 tccgcaagga cggccgtcac gaggcacatc cgatcgtcac cgcggagccg gtcaccggcg
    22621 ccgcggtgac cggctcggac ggggtgagtg catccggggc cgccaccact cggtacaggt
    22681 aggggcaggt cacgcctcac acgaaaagga gatggcggtg ccgcacatcg acccgacgcg
    22741 catggtggag ctggcgctgg gacacgacgc ctcgcacagc gacgtcagtg cctggcagca
    22801 catcggcgtg tgcgagcgct gcgaggagga actgcgcctg acgacctggg tcatcaccgc
    22861 cgcccgctcg gtgcaggagc cggatctcct cgcatgccct ccggagcgag tgtggcagca
    22921 catcgcacaa gaactggcag agccatgcga agccaccccg ccacccccgg cggcgtcgct
    22981 gtgcgggcct ccggcagtgt cggctgacgc ccgccgcagg cgttccccgg gcaccgggag
    23041 ccgaaggacc ccgttggcgt gcggcctgct cgccggcctc ctgatcgtgt ggtggcgcag
    23101 gcggaagcga tcgttcaggc catccgaatc ggcgagcgat cacccgcccg tgtgagaacc
    23161 ggatcccact cggcacccgc cacccagcac tcggcactcg gcactcggca ctcggcactc
    23221 ggcactcgga gcacgcgaac gccacggtga cgggccgcgt cacctgaagc agccggtcag
    23281 ccgagccggg ctcgtcctgc gggcgcaggg gcaggcgggg gccgtccagt tccgccgtcc
    23341 cggctggacc cgggcctcgg acgggatcga cgccggcctc ccgcatggag gtcggcgtcg
    23401 acaggcgtcg tcgtgggact ggaacggcgg gtcgtagcag ctgaccaaag caacggaccg
    23461 gacccgtcgt cgggatcgcg ccaatgaccg gccaccccat ccctgacggt caccggcccg
    23521 tggacgccgg cggcactcac gccgaggcgg tttgcctgga gccaccgaac ggcatccacc
    23581 gtgccggtgc cgcagagccc gtccgcccct ccgccggcgc ggatccgatc ggcggcaggg
    23641 gtgtgccgta gcggcgaagg atggccctcc agcgccttca cggcgtccga gctgccacca
    23701 gaggtactcc ggggtcgtcc gcgtacgaca gcgctgtcga catcgtcgcg tccacccgcg
    23761 ccctggcctc agcggacgta ggcgtcacag agccccttca cggacggcgg cacgggcgcc
    23821 tggtgcgaca gtccgcacag ggacttcagg ccgtaggtgg cggtcggcgg ctgtgcgggg
    23881 cgaggcggga ccacccgggg acggggcgcg gccggggccg ccggccgagc ccggggacgg
    23941 gccggcacgg gtggcgcagc cgtccgcggc cgctccggtg cacgggtccg cggccgctgt
    24001 cggggagtgg ggacccttga ggaacgctgc tcctccactg ctgcggcttc gcgaccgctg
    24061 cccctcagca tcggggtggt gtcggtcgtg acgagggcgg tgcgggcgga cggctggctc
    24121 gcggccggca cccgagacgg cgtacgggtg acagcacggc tgggggacgg cacgggcgac
    24181 ggcgtccgag ccgcggccgc catcagcgaa ggcgggggct caggcgggcc gaccgtgggg
    24241 acggatacgc accccccgac gcagagagcg gcagccaggg cggggatgag ggcgagcggg
    24301 tgacgcatgc cttcagggtg gctgtgcacc acacggtgtg ggagcaacct cgcaggtgat
    24361 caccgggacg ggtgacgcct gagagcctcg cgctccgctc acaggaccgg ccaggggtcg
    24421 ccgccgtacc agccgcggcg cgtgcggacg gcggccgtcg cgtgtacgcc gggcgaagtc
    24481 cccctcagtc ccagggggtc ggtcgtcgcc ttcacgtcca ctccgatgtc gccctgttcg
    24541 tacctgacgt cttccggggc ccagggccac cggcaaccgc ggcctctcgc accctgctgc
    24601 tcccctcaca gccctggcgt ccgtacggcc gaacggcccg cgcgtgtccg atgcgatgcg
    24661 tccgtgcgca tgtccttcgg ggccgcggaa ggacgtcacc ggtcgagact ggtggtttac
    24721 gcggtcccgg gcgccggacg gctgacgaga cttcgagtcc gttgtcgtcc ttccgcacgg
    24781 aggtgccgat gtccggtccg cttgcaagac tttcgacgac atgccgtcga cgatggctct
    24841 cgccccgacg cctggtggtg ccggcggtcg ccctgctgct gtcggccacc gcgatgacct
    24901 ccgcgcccgc cgccgcggcc gagggaccga tcgtcacgac ccggtacggc caggtccagg
    24961 ggaaggtggg cgagaccgcc acctcctacc tcggcattcc ctacgccgca ccaccgaccg
    25021 ggccgttgcg gtggaggccg cccgtcccgc ccgcgcgatg gtcgggaatc cgggacgccc
    25081 gtactccggg caacccctgc gtgcagcgcg tccagtccag cccttggggt gatctcgcgg
    25141 gacccggcac tccgagtgag gactgcctgt acctgaacgt ctacacaccc gcgcagcgct
    25201 ccctccagaa gcgaccggtg atggtgtgga tccacggcgg tggcttcacc gtcggctccg
    25261 gcacgttcta cgacggtggc aacctggcgg ccaagggcga tgtggtggtc gtcaacctca
    25321 actaccgact cggcgctttc ggctacctcg cccacccgag cctggccaag gagtcggcgc
    25381 agggaatctc cggcactacg gcctgctcga ccagcaggcc gccctgcgct gggtgcagga
    25441 caacatcgtg gcgttcggcg gcgaccccga caacgtgacg atcttcggtg agtccgcggg
    25501 aggcggcagc gtctgccaga acctggtctc gccccgcacg accggcctgt tcgaccgggc
    25561 catcgcccag tccggctgcg gattccccct gcccacccag gagtcgcagc agaacaacgg
    25621 gcaggcctgg gccgactccc tgggctgtgc ggacgcggcc tgcctgcgaa ccaggaccgc
    25681 gcaggaactg ctcacggcct cggccgcccc caccgcccgc tggacgccca acgtcgacgg
    25741 caaggtcctc cccctgcagg tgccggccgc cctggacatc ggacgcttcc accgcgtccc
    25801 cgtccttcag ggcaccaccg ccgacgaagg ccggctcacg gtggcgacca cctacgacct
    25861 ggccggccgg cagctcaccg ccgcgggcta cccggtggcg gtccgcgcgc tccacggtga
    25921 acgagccgac gagatcctgg cccgctaccc gctgtcggac tacggcacgc ccgcggaggc
    25981 tctcggcgcg gtcctcaccg actcccagtt cgcctgcctg caatcccgca ccgcgagcct
    26041 gatggccgag cacacccgct cctaccagta cgagttcgcg gaccgtcacg ccatggacta
    26101 cctgaacatg ccgatcagct tcccgatcgg cgcaccgcac ggctcggaga tccggtacgt
    26161 cttcggcagc gtctcaggca cacccgccca gaacgccctg tcggacagca tgctcggcta
    26221 ctggaccaac ttcgccagga ccggtgtccc gtacgccgcg aaagcgcctc gttgggacct
    26281 cttccccaag gtgcaggtcc tcgccccgga agcgatcacc tcggtgctca ccttccccgc
    26341 ggaccacaag tgcgacctgt ggagcccggc caccgcctga cggccggcac cttcgtgtgg
    26401 ctccggcggg gggcgcggac cggtcggcat ccactgccga accggctggg tgacaccgga
    26461 gccaccaccc ttgcgacacg ggacgtccac gggaccgagc gacaggtgcc gaccgattcc
    26521 gttcgcacgt gtgcccgatg gaagatcacc taaagtacgc ggcatgacgc tgcaacttgt
    26581 tcaggtgaac ttcaaggccc gggacgactc ggcgctcggc cggttctggg cggaggtgct
    26641 cggctggggt gtttccagcg aagggcccgg ggtcaccaac ctggaacccg tgggcttcga
    26701 ctggccggac ccgtccgccg tctgcatcga tctcgtccgc gtgccggacc cggagacggt
    26761 gaagtaccgc gtgcacatcg aactcgccac cacctccgac gcccatcagg cggagttggt
    26821 cgcacgtctg aaggaactcg gggcgaagcc cgccgatgtg ggccagggcg acacgccgtg
    26881 gacggtgatg gccgacccgg aaggcaacgt gttcagcgtc ctggaacccc gtgagctcta
    26941 ccaggacacc gggccgatag ccgccgtggt cgtcgcctgc gccgacccac gggccatggt
    27001 ccggttctgg ggcgaggcga tcgactggac cgtccacgag ctgaccgacg accgggccct
    27061 gctgcgctcc gtcaagggcg tcgggccgta cctcgagttc cgccgtacgc ccgatgacga
    27121 ggtcgtatgg aaccgcctcc atctcgacgt gatgtccgac ccggtcgagg atcaggcgag
    27181 ggaggtcgcc cggctccaga gcctcggcgc ggtacgggcc gacgtgggtc agggtgatga
    27241 cgtctcctgg gtcgttctgg ccgacccgga gggcaacgag ttctgcgtcc tgggccgggg
    27301 ctgacgcggc actccgtccg cgcctcttgg cgcgcggcag tgcgcggtgc ccggcccagc
    27361 cctccccggg caccgcggat cgtccaccgg ctggcccggt gctgtgaccc ggcatgccgg
    27421 gcgagcgcgt tcagggcgtc accggtcgga gtgagcggta gccggtccgt ccacagcagg
    27481 ccctgtgtga ggccatggaa cgcctcctca ccgggcgacc gatccgcacc gacggcaagc
    27541 tcactaggac gatctccggc acgaggccgg ccgcagccgg gccgttgaac gcccgtgaac
    27601 cacccggacc gttgcggctc cgtccccggc cactgcatct cgtggtccgg aggtgtcccg
    27661 tccgaggacg gaatctcgtc gctctccaag aatgctgctc gcgccgcgcg gacagcttcc
    27721 tccacagcgg ggtcggccgg tcggaacggc cgccgcagga ggcgaacacg ccacccggct
    27781 ccagcagcgc ggccatgcgg gtccaccggc cctccgggtt cgtccaatgc agcgccgctg
    27841 ccgcatggac cagcccgtac cgttcgcccg gccgcaagtc ctcgaacgca gcgtgcgccg
    27901 tcctgacgcc ggcgggcacg tgcttgcgca actcggcgag catggactcg tcgggatcgg
    27961 tcgcggtcac cacgatccct cgtcgggcga acgggcgggt cgccttgccc gtcccagcgc
    28021 cgatcccaag ggcagtccgg accggatggc ctgcgtatgc catcaccatg tcgaacagtg
    28081 cctcgggata ctccggccga aaccgttcgt aggcttccac aaccactccg aagctcagcg
    28141 cgcgccagac atgccgcgca tcccgacacg agccgcgctt tcggtggttg ttccgattgc
    28201 ggcccggcca cgagctgatg tctgatcaca catcagcgat cgggagaggg atgatcgcgg
    28261 actgatctgt cacagcgtca gtggcggtct gccaccagag gattgccagg aagcggactt
    28321 gtcaacctga cacatgtgag gttcacggga cccggaccgc ttgtgaggat gttgctcacg
    28381 caaccggcgc gccgaccagt gacaccgcgc cgccgggtac tcgcaaacga ggggaaacca
    28441 atgctcgaca agatcaagcg gaccgccgcg gcactggcac tggccaccgg
//
