LOCUS       NZ_MPOH02000008        20702 bp    DNA     linear   CON 03-MAY-2024
DEFINITION  Streptomyces phaeoluteigriseus strain DSM 41896 Scaffold_8, whole
            genome shotgun sequence.
ACCESSION   NZ_MPOH02000008
VERSION     NZ_MPOH02000008.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces phaeoluteigriseus
  ORGANISM  Streptomyces phaeoluteigriseus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
REFERENCE   1  (bases 1 to 145619)
  AUTHORS   Salih,T.S., Algora Gallardo,L., Melo Santos,T., Filgueira
            Martinez,S. and Herron,P.R.
  TITLE     Draft genome sequence of Streptomyces phaeoluteigriseus type strain
            DSM41896
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 145619)
  AUTHORS   Salih,T.S., Algora Gallardo,L., Melo Santos,T., Filgueira
            Martinez,S. and Herron,P.R.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-FEB-2017) Strathclyde Institute of Pharmacy and
            Biomedical Sciences, University of Strathclyde, 161 Cathedral
            Street, Glasgow G40RE, United Kingdom
REFERENCE   3  (bases 1 to 145619)
  AUTHORS   Schniete,J.K., Salih,T., Algora Gallardo,L., Martinez Fernandez,S.
            and Herron,P.R.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-NOV-2016) Strathclyde Institute for Pharmacy and
            Biomedical Sciences, University of Strathclyde, 161 Cathedral
            Street, Glasgow G40RE, United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 26-JAN-2017
            Assembly Method                   :: SPAdes v. 3.9; MeDuSa v. 1.6
            Genome Coverage                   :: 65.0x
            Sequencing Technology             :: IonTorrent
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001896135.2-RS_2024_05_03
            Annotation Date                   :: 05/03/2024 03:12:26
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,918
            CDSs (total)                      :: 7,837
            Genes (coding)                    :: 6,622
            CDSs (with protein)               :: 6,622
            Genes (RNA)                       :: 81
            rRNAs                             :: 3 (5S)
            complete rRNAs                    :: 3 (5S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 1,215
            CDSs (without protein)            :: 1,215
            Pseudo Genes (ambiguous residues) :: 0 of 1,215
            Pseudo Genes (frameshifted)       :: 907 of 1,215
            Pseudo Genes (incomplete)         :: 407 of 1,215
            Pseudo Genes (internal stop)      :: 30 of 1,215
            Pseudo Genes (multiple problems)  :: 120 of 1,215
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:00:38
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 44431
            Orig. end                         :: >65133
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            MPOH02000008.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..>20702
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..>20702
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..>20702
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:>10702](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..>10702
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    210..228
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 22.87"
                     /tool="antismash"
     misc_feature    complement(234..248)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 24.85"
                     /tool="antismash"
     misc_feature    235..249
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 24.7"
                     /tool="antismash"
     gene            480..689
                     /locus_tag="BM536_RS07245"
                     /old_locus_tag="BM536_007210"
     CDS             480..689
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BM536_RS07245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BM536_007210"
                     /product="hypothetical protein"
                     /protein_id="WP_073494224.1"
                     /transl_table=11
                     /translation="MEQIIEAKREEKPGPDAPEPEKPGRVLDLMAALEESVSAAKAPRG
                     EDSDVHDSRWRKAPRTGPARSAVL"
     misc_feature    complement(481..495)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.51"
                     /tool="antismash"
     gene            complement(991..1896)
                     /locus_tag="BM536_RS07250"
                     /old_locus_tag="BM536_007215"
     CDS             complement(991..1896)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (12-215). E-value: 1.3e-31.
                     Score: 101.8. Matches aSDomain:
                     nrpspksdomains_BM536_RS07250_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_109005319.1"
                     /locus_tag="BM536_RS07250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_007215"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_073494226.1"
                     /sec_met_domain="ADH_N (E-value: 2.2e-10, bitscore: 33.8,
                     seeds: 66, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAARFHEYGGAERLVIEQAPDPHPGPGEIRVRVAAASVNPIDWK
                     LRSGALHQIFPLDLPDIPGRDGAGVVDEIGDGVQGVSIGDRVFGLGGVTGATAELLILS
                     AWAHTPATWNDEQAAGAGLASVTAMGGLNALGSLAGRTLLVEGAAGGVGSAAVEIAVAQ
                     GATVIGTASERNHEFLTSLGAVPTTYGPGLAQRLVTLAPHGVDIALDTAASGSLDDLVA
                     ITGDPKRVATVADHAGGQRLGTHVVNAANDSTLLSAAAELGGQGRYTPRIEQSYPLERI
                     ADAHAHAERGRTRGKIVICI"
     aSDomain        complement(1252..1860)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BM536_RS07250_PKS_ER.1"
                     /evalue="1.30E-31"
                     /label="BM536_RS07250_PKS_ER.1"
                     /locus_tag="BM536_RS07250"
                     /protein_end="215"
                     /protein_start="12"
                     /score="101.8"
                     /tool="antismash"
                     /translation="ERLVIEQAPDPHPGPGEIRVRVAAASVNPIDWKLRSGALHQIFPL
                     DLPDIPGRDGAGVVDEIGDGVQGVSIGDRVFGLGGVTGATAELLILSAWAHTPATWNDE
                     QAAGAGLASVTAMGGLNALGSLAGRTLLVEGAAGGVGSAAVEIAVAQGATVIGTASERN
                     HEFLTSLGAVPTTYGPGLAQRLVTLAPHGVDIALDTAASG"
     CDS_motif       complement(1417..1479)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BM536_RS07250_0001"
                     /evalue="8.80E-06"
                     /label="PKSI-ER_m5"
                     /locus_tag="BM536_RS07250"
                     /protein_end="160"
                     /protein_start="139"
                     /score="18.3"
                     /tool="antismash"
                     /translation="GRTLLVEGAAGGVGSAAVEIA"
     misc_feature    complement(2202..2217)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.27"
                     /tool="antismash"
     misc_feature    2225..2239
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.37"
                     /tool="antismash"
     gene            2323..2679
                     /locus_tag="BM536_RS07255"
                     /old_locus_tag="BM536_007220"
     CDS             2323..2679
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009067023.1"
                     /locus_tag="BM536_RS07255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_007220"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_073494249.1"
                     /transl_table=11
                     /translation="MRIGQLARRSGVSVRALRYYEEQRLLESTRTPGGQRDYPDEALER
                     VQLIQDLFAAGLSSRTVVELLPCVSTGVATLAMLDQLIIERDRIAARIQDLTRAKTKLG
                     RVIENVTAANVAQD"
     gene            <2749..3017
                     /locus_tag="BM536_RS07260"
                     /pseudo=""
     CDS             <2749..3017
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007266273.1"
                     /locus_tag="BM536_RS07260"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="PVLGERSALLNGALQAAYFIIGIRDTGYGLRAWRPDP"
     gene            complement(3045..3410)
                     /locus_tag="BM536_RS07265"
                     /old_locus_tag="BM536_007225"
     CDS             complement(3045..3410)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018565210.1"
                     /locus_tag="BM536_RS07265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_007225"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_245873306.1"
                     /transl_table=11
                     /translation="MDAMIIAAPTPERGARGDQLRRRCRKLAILKQLVVGTHRFGELRR
                     ALPGITQRMLTRQLRELEADGLVTRTVYREVPPRVEYALTDVGHSLDSITEELDKWGRW
                     YRETVRPEGPSGPRPPA"
     misc_feature    complement(3234..3236)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            3400..4554
                     /locus_tag="BM536_RS07270"
                     /old_locus_tag="BM536_007230"
     CDS             3400..4554
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="BM536_RS07270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_007230"
                     /product="MFS transporter"
                     /protein_id="WP_158086506.1"
                     /transl_table=11
                     /translation="MASTVAIIRVVFTDDRERAVAIGIWTAAHSVGATIGPLVGGLVTA
                     EWGWGAVFLINVPVIVVILAVGTRVIPESRNPVSRRWDLASVALSVTGLAGVVYALKQA
                     GEHSGVNGVIVTTAVVGSVLLHLFVRRQRRIAEPLLDFSLFHERRFTTATLCVIGCFGS
                     YVALLFFLTQWLQQVGEYSPLRAGLALMPLAGANAIGAVTAPWAANRWGNRWALTGTLA
                     LFATALTVMAVVGDTAHYGVLLVPLLGAGYGAGIVMTLGADSIMSAAQPDRSGEAAAIQ
                     ETSFELGAGLGVAVLGTVLTAVYRTGLPQVPGLGPDGRAMAEESFAHAEGLTANLPSET
                     AQTLQRAAQQAYDHGFTTVLTLAAIGLVVTAAMAAVLLRPPKTR"
     gene            complement(4631..4891)
                     /locus_tag="BM536_RS07275"
                     /old_locus_tag="BM536_007235"
     CDS             complement(4631..4891)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BM536_RS07275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BM536_007235"
                     /product="hypothetical protein"
                     /protein_id="WP_073494230.1"
                     /transl_table=11
                     /translation="MKPPRLSGAFLRFKVKTTLIGMFLVLAASLFVHTVISPPRTDPPP
                     FSPPPSAQNVWPEASLPPLILPTFTLPPPGRLTTPPLLPVK"
     gene            complement(4888..6066)
                     /locus_tag="BM536_RS07280"
                     /old_locus_tag="BM536_007240"
     CDS             complement(4888..6066)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013594.4"
                     /locus_tag="BM536_RS07280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_007240"
                     /product="M48 family metallopeptidase"
                     /protein_id="WP_073494232.1"
                     /transl_table=11
                     /translation="MTGTKPAATTSRALLGCALLAGVHLLAVAVLATQLLLVIAILTTN
                     AWQFAVLGSLTVVPTSALAYGLLARASADVAEGPRIVLTPQQQPELWALTLQLADELGT
                     AAPATMRLADTVNAYAGERGKLLGLIGGPRTLDLGLPLLLGLTRDELRAVLCHELGHYA
                     GRHTRLAAVSRRGSVALERTVRYLEVLETDQTSVKPPVRLLLKLTKAYNGVYLRQTLAV
                     RRSQELEADAAAARIAGAHTFAQALRTVHALTPLWDEFTENRARPEGPPAPAAGKGGVG
                     SLPRLMLPDGVFRDFADRLADLVGRPFADGRGTSALDIVSKDGLGSHPPLAVRLAALCP
                     DGDPDSTHRPAVSAGPPAAGLLRDLPELVEALQDAMRPVGARPPHRPVPQCR"
     misc_feature    complement(4951..4953)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(6063..6809)
                     /locus_tag="BM536_RS07285"
                     /old_locus_tag="BM536_007245"
     CDS             complement(6063..6809)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:TIGR02937.1"
                     /locus_tag="BM536_RS07285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_007245"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_073494234.1"
                     /transl_table=11
                     /translation="MSGGTGSVRAGAQEPAPVGGDEAAEDGRAPVDFDVFFTAHRPALL
                     ARAVMLCGNRQDAEDAVQDAFLAALENWDRISGYEQPNAWVSLVMRRKLWRALRLRLKV
                     KRAALDVALPRQALPDETAQARRVLTAMAALPPRQRMVLVMYSLYAMTHQEIADDLNIA
                     VSTARGNLRKGRDNLRRMLGLAPGTDPLGEVSLVGTGGPAPGDRLAAALSATEFWLCSA
                     FEEDEQAPRQARADLAGRQREGTGRK"
     gene            complement(6806..7027)
                     /locus_tag="BM536_RS07290"
                     /old_locus_tag="BM536_007250"
     CDS             complement(6806..7027)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BM536_RS07290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BM536_007250"
                     /product="hypothetical protein"
                     /protein_id="WP_143650838.1"
                     /transl_table=11
                     /translation="MIAVLAATVRIALEVVAWQRELARERERGRLVLAALRQAGHGVQV
                     EDRRPDGGVLTVRGDGLAASSGQEGEAR"
     gene            8514..9122
                     /locus_tag="BM536_RS07300"
                     /old_locus_tag="BM536_007260"
     CDS             8514..9122
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018957964.1"
                     /locus_tag="BM536_RS07300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_007260"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_073494240.1"
                     /transl_table=11
                     /translation="MEIRDVHHAYRQRVVLRGVDLRLRAGTLCGIVGENGAGKSTLLKI
                     LSGELRPTHGSVRHSGRFGYCPQHVVLNDALTVRQHLTFFQTAYRLTDVRYAEEIMDVL
                     GFTGYADERAGVLSGGTRQKLNVTLALMHDPQVLLLDEPYQGFDWDTYQRFWDLAARLR
                     DAGRSVLVVSHLAYDTERLDELWRLDSGMLRAEKAGAAA"
     gene            9119..9984
                     /locus_tag="BM536_RS07305"
                     /old_locus_tag="BM536_007265"
                     /pseudo=""
     CDS             9119..9984
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016828366.1"
                     /locus_tag="BM536_RS07305"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_007265"
                     /product="ABC transporter permease"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRFHLTRFAVATRFTLIEHGRNRFAMVLVILFVPVWASLAYLAMP
                     DTPTRMRLRATGEALAPHGNELTAISGALNAVTLITGFMMFAATFSGSGFDRRLAMAGY
                     PRAHLVLAKVTALALVSAAVAAYATAVICLAWTPASLCCSPPPCSAPDSLTALWESSSG
                     PCCAGKSRGCSPS"
     gene            10001..>10702
                     /locus_tag="BM536_RS07310"
                     /old_locus_tag="BM536_007270"
                     /pseudo=""
     CDS             10001..>10702
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012705.4"
                     /locus_tag="BM536_RS07310"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_007270"
                     /product="squalene/phytoene synthase family protein"
                     /pseudo=""
                     /sec_met_domain="phytoene_synt (E-value: 1.3e-27, bitscore:
                     90.0, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 3.7e-09,
                     bitscore: 29.4, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHTTTYSTTADLDAALPAQRGRPTHHPPIGEAPSLRAAYRLCRRT
                     TRVHDPGIYALIQLMPTVLRPPCWALWAAASVLDDLADQQDAQQADRETRVQAWSQALQ
                     CDLAAGTSADPVRHALVDTALRWRLDLSSLQSAMTSTRDDVRGQHFADWAAWRAWCNGA
                     ITAWVDQVRHLFERAGAPMTFRLDRQQDYKRFIDGAQLTDTLTDLSADLAQGDLLLPQE
                     ALDAFPGAEDDL"
     gene            <10706..>10948
                     /locus_tag="BM536_RS44280"
                     /pseudo=""
     CDS             10706..>10948
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007454547.1"
                     /locus_tag="BM536_RS44280"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="type II toxin-antitoxin system PemK/MazF family
                     toxin"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGNPFEGVLRLAFPRPGFTPCTWLTTVSRDDLIERAAVLSSAKLS
                     EIDDALRLAEQAQEQTPATTAKLSEMRDALRLGELG"
     gene            11181..11426
                     /locus_tag="BM536_RS42505"
     CDS             11181..11426
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024940.4"
                     /locus_tag="BM536_RS42505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_245873307.1"
                     /transl_table=11
                     /translation="MLAVDGFARGEKNTVIARELRVSVRSVQHWRRSWREGGRQALRPS
                     GPAKRPKVGDSDFAVLEALFLDGAMARWRDGAGLGG"
     gene            11476..11673
                     /locus_tag="BM536_RS42510"
     CDS             11476..11673
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) darobactin_precursor"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024980.4"
                     /locus_tag="BM536_RS42510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="winged helix-turn-helix domain-containing
                     protein"
                     /protein_id="WP_245873316.1"
                     /sec_met_domain="darobactin_precursor (E-value: 1.0,
                     bitscore: 7.0, seeds: 0, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLSIRGVWELLRRQGWSCQQPARRAVERDDAAVVGWVKESWPWA
                     KPPRRRSGHVWSSRTRPLSR"
     gene            11670..12217
                     /locus_tag="BM536_RS07320"
                     /old_locus_tag="BM536_007280"
                     /pseudo=""
     CDS             11670..12217
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019072331.1"
                     /locus_tag="BM536_RS07320"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_007280"
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTSHRARTWAPRGSTSAVRFNGASRGRIPMATLVCFKAGERSRLI
                     YRPRIQGHHRGAHHCFTWQDYRDLLVRAGLQLGGPVVVIWDNLNVHRSSRFREYAAEHD
                     WLTIVQLPSYAPDLDPVEGIWSLLRRGTTATSSSPTATTSSHRSAAACARSSGNPTSST
                     VASPKPASHSIRQLHGKLS"
     misc_feature    complement(12422..12436)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 21.67"
                     /tool="antismash"
     misc_feature    12423..12434
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.78"
                     /tool="antismash"
     gene            12682..13692
                     /locus_tag="BM536_RS07325"
                     /old_locus_tag="BM536_007285"
     CDS             12682..13692
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015658309.1"
                     /locus_tag="BM536_RS07325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_007285"
                     /product="peptidase"
                     /protein_id="WP_094102707.1"
                     /transl_table=11
                     /translation="MRGIPRVTGTRGSLPGALVGVTALLTTGLLAAPAGAAPSRPDAAV
                     RSVSVDAQRHAQQFWTPERMKAATPLDLVTVADRVDRGSAPAQGRKITVDPTTPKAAPV
                     DAGVMAFPSGGGQWTGGGAVLSTAGRVFFTYQGRTASCSGNAVTSSNKSTVITAGHCVK
                     LEGAWHTNWVFVPGYHDGQAPYGRWTASKTLSTPQWTASEDINYDIGAAVVAPLDGKRL
                     TDAVGGQGLAFNTGYNLAMYSFGFPAASPYNGEKFIYCSGTTNRDFLLSNDHGMTCNMT
                     GGSSGGPWFTQFNESTGAGLLSSVNSFKYNFLPNRMYGPYFGADAQNLYQTAQSS"
     gene            complement(14128..14277)
                     /locus_tag="BM536_RS42515"
     CDS             complement(14128..14277)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BM536_RS42515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="ATP-dependent DNA ligase"
                     /protein_id="WP_245873308.1"
                     /transl_table=11
                     /translation="MLVEPELVAEVGVDVARDASGLWLHPARLHRARPDLSNADVPCWT
                     SPPR"
     gene            complement(14493..15422)
                     /locus_tag="BM536_RS07335"
                     /old_locus_tag="BM536_007295"
     CDS             complement(14493..15422)
                     /EC_number="3.2.2.-"
                     /GO_function="GO:0016799 - hydrolase activity, hydrolyzing
                     N-glycosyl compounds [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014140702.1"
                     /locus_tag="BM536_RS07335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_007295"
                     /product="ADP-ribosylglycohydrolase family protein"
                     /protein_id="WP_094102708.1"
                     /transl_table=11
                     /translation="MKRIQRAAGAVVGSAVGDALGAPFEFGPPGAFSARFPAPGAGGEM
                     CGGGGWDPGEATDDTQMAVLVAESLLERGGLDLPDIFVRFQRWAASEPKGIGLQTDDVL
                     TNGMPWDLAAAIHFQVNQRAAGNGSLMRASTSAVHFAPAGQRATMDAAHRIAALTHGDR
                     AAWEGTAIFHELIRLTFEDTDPLAALPDILALVHPDHRGRYATVLAPDWHPDQATEFNG
                     AVWPCLGSAVWALRTTTSFEDAIRAAIDLGGDTDTVAAVTGGLAGAYYGLDAIPARWTQ
                     PLHVPLPGFDGRVLHLADLLHLAHRLGG"
     gene            complement(16141..16845)
                     /locus_tag="BM536_RS07340"
                     /old_locus_tag="BM536_007300"
     CDS             complement(16141..16845)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (14-123). E-value:
                     2.5e-15. Score: 48.7. Matches aSDomain:
                     nrpspksdomains_BM536_RS07340_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.4"
                     /locus_tag="BM536_RS07340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_007300"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_073494243.1"
                     /sec_met_domain="PF00561 (E-value: 1.5e-12, bitscore: 40.9,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 5.9e-18, bitscore:
                     59.5, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="Thioesterase (E-value: 4.4e-10, bitscore:
                     33.4, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGSARLDEGEGDGGPLVLVPGLGAPGYLLRTGARCARSGAVRVLD
                     VPGFGDPSGPACPETLEGLADLVARWLAVVPDGPVVLAGHSTGAQVALHAALRRPERVR
                     ALVLLAPTFPPRLRRVRPLLAAFARTAVHESPGVVPTLLPSYLAAGPRRLAICVRSAQT
                     DAPEDVIASVSCPVTVVTGENDALCPPDWTRELARRAEEGRAVRMPGAHAFPYTHPAAT
                     AALLARVPGRSR"
     aSDomain        complement(16477..16803)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BM536_RS07340_Abhydrolase_1.1"
                     /evalue="2.50E-15"
                     /label="BM536_RS07340_Abhydrolase_1.1"
                     /locus_tag="BM536_RS07340"
                     /protein_end="123"
                     /protein_start="14"
                     /score="48.7"
                     /tool="antismash"
                     /translation="PLVLVPGLGAPGYLLRTGARCARSGAVRVLDVPGFGDPSGPACPE
                     TLEGLADLVARWLAVVPDGPVVLAGHSTGAQVALHAALRRPERVRALVLLAPTFPPRLR
                     RVRPL"
     CDS_motif       complement(16558..16620)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BM536_RS07340_0001"
                     /evalue="6.20E-07"
                     /label="NRPS-te1"
                     /locus_tag="BM536_RS07340"
                     /protein_end="96"
                     /protein_start="75"
                     /score="21.9"
                     /tool="antismash"
                     /translation="PDGPVVLAGHSTGAQVALHAA"
     gene            17070..17516
                     /locus_tag="BM536_RS07345"
                     /old_locus_tag="BM536_007305"
     CDS             17070..17516
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005308221.1"
                     /locus_tag="BM536_RS07345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_007305"
                     /product="DUF4383 domain-containing protein"
                     /protein_id="WP_073494245.1"
                     /transl_table=11
                     /translation="MNTRTPMTSARTPVQQAALLVGAVFLLVGVLGFIPGITTDYDTMK
                     FASHDSGAELFGIFQISVLHNIVHLLFGVAGLVMARTASGARTYLLAGGAIYLVLWLYG
                     LFVGHTSDANFIPLNNADDWLHFVLGIGMIALGALLTRRTARRI"
     gene            18103..19044
                     /locus_tag="BM536_RS07350"
                     /old_locus_tag="BM536_007310"
     CDS             18103..19044
                     /GO_function="GO:0045027 - DNA end binding [Evidence IEA]"
                     /GO_process="GO:0006303 - double-strand break repair via
                     nonhomologous end joining [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010982317.1"
                     /locus_tag="BM536_RS07350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_007310"
                     /product="Ku protein"
                     /protein_id="WP_094102710.1"
                     /transl_table=11
                     /translation="MPRTIWSGAISFGLVTVPINVVSATEDHSIRFHQYHLEDGGRIRT
                     RKVCELEDREVGQGEIGKGYEVTKTQVIPISDEELRDLPLPTAKSIEIEAFVPLESVDP
                     IRIGEGYYLQPAGQVAAKPYKLLRQALARSAKVAVAKYAWSGRERLGLLRVRDDVIVLH
                     AMRWPDEIRDPAELLPPPVEISQDEIDGALALMDTMTRDDLEGEEFRDTYTDALAQVIE
                     AKQGDKPLPEVPQAEEPGKVLDLMAALTESVSRAKAARGETGDADVHDLPKKQTAVKKT
                     AKKTPAGKTTQKTTASKKTAAKKTAGRRPRSA"
     misc_feature    complement(19063..19078)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.07"
                     /tool="antismash"
     misc_feature    complement(19424..19435)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 19.87"
                     /tool="antismash"
     gene            19911..20216
                     /locus_tag="BM536_RS07360"
                     /old_locus_tag="BM536_007320"
     CDS             19911..20216
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BM536_RS07360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BM536_007320"
                     /product="hypothetical protein"
                     /protein_id="WP_073494921.1"
                     /transl_table=11
                     /translation="MTADAVEKLLADVCGTLARAGFDVASAGDEGSPGLRVRRDTDSVL
                     VGWVPGSELDPAGREDTEFEGIRAALRSALLAILTQAGHPVQVDHASGEVRVRLLA"
     misc_feature    20070..20072
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            20394..20618
                     /locus_tag="BM536_RS42520"
                     /old_locus_tag="BM536_007325"
     CDS             20394..20618
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018961019.1"
                     /locus_tag="BM536_RS42520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_007325"
                     /product="hypothetical protein"
                     /protein_id="WP_073494923.1"
                     /transl_table=11
                     /translation="MTSAPIVVHQPSRTGGRGVTVHSHGRDEILGTAYSDHDLVVSFQA
                     AGVDEPEAVLDDPRWMEWRGGRPHEWRTA"
ORIGIN
        1 acgcccggat cgcccacctg gatctggcag tcggagtccc gcccgaccag catcggctgg
       61 tcgtcgagca cgaagacccg gccacgcagc cggtccgggc ggtcgaccac gagttgcggt
      121 aggtcgcgct ctcgcagagg cgggtccatg gcacgacctc ctgccttggc gaagcatccg
      181 gcgtcgggcg aaacgattcg gtcgcctatt gaggtgatcc tcaccttcca gtaaaggccg
      241 atcggccccg tcctgccaca gcatcccgga cggccggaac tcggcagtgc gttcggccgc
      301 ccgtcccctc ggtccgcagc cctccgatcc cgacgggctg atccccgcga ctccaccgaa
      361 ctcctcccgg agcccgccga cgtgtccgag aaggagatca agggcgcgct cgcgttgatg
      421 gagtcgatgt cccgtgacga cctcgaaggc cacgacttca aggcacctac accgaagcca
      481 tggaacagat catcgaagcc aagcgggaag agaagccggg gcccgatgcg cccgagccgg
      541 agaagccggg ccgggtcctc gacctgatgg ccgcgcttga ggaatccgtg tccgcggcga
      601 aggcgccccg cggcgaggac tccgacgtac atgattcccg atggaggaag gcccctcgca
      661 ccgggccggc cagatcagcg gtgctgtgag ggaagcgggc gcacaggcga gaggcggcga
      721 ggtccccggc cgaccgcggt gcgggcccgc ctctgagaac cgtatttgaa cccctctcac
      781 gggctgctga agctggatga ggctggtgcc ccgtggacga cggttcatgt gccacgtgtg
      841 gtgcccgagt gggggcggcc tgcttgacga gccgccatgg agatcggccc gcttcggacc
      901 gcccgctcgc cggtaccgat cgaggccacg caggcccgca cgttgcgagt tacctacctc
      961 gtgggcctgt tcggatacag atcagcctgc tcagatgcag atcacgatct ttcctcgggt
     1021 gcgcccacgc tcggcgtgcg cgtgggcgtc ggcgatccgc tccagggggt aggactgttc
     1081 gatacggggt gtgtagcggc cttgcccgcc cagttccgcc gccgcggaca ggagagtgga
     1141 atcgttcgcc gcgttgacca catgcgtgcc caggcgctgc ccgcccgcgt ggtcggcgac
     1201 cgtcgcgacg cgcttcgggt cgcccgtgat cgcgacgagg tcgtccaggg agccggaggc
     1261 cgcggtgtcg agcgcgatgt cgacgccgtg cggagcgagg gtgacgaggc gctgtgcgag
     1321 gccggggccg taggtggtgg gaacggcgcc gagagaggtg aggaactcgt ggttgcgttc
     1381 gctggctgtc ccgatcacag tggcaccttg cgctacggcg atctcgaccg ccgcgctgcc
     1441 cacgcctccg gcggcgccct cgacgagaag ggtgcgcccc gcgagggagc cgagcgcgtt
     1501 cagtccaccc atcgcggtca cggacgcgag accggcacca gcggcctgct cgtcgttcca
     1561 cgtggcgggg gtgtgcgccc aggccgagag gatgagcagc tccgcggtcg ccccggtgac
     1621 accgcccagc ccgaagaccc ggtcgccgat gctcaccccc tgcaccccgt cgccgatctc
     1681 gtcgaccaca ccggcgccgt cgcgcccggg aatgtcgggc agatccagag ggaagatctg
     1741 gtgcagggcg ccggagcgca gcttccagtc gatgggattg acgctggccg ccgcgacgcg
     1801 gacacggatc tcaccgggtc cggggtgggg gtctggggcc tgctcgatca ccaggcgctc
     1861 cgctccgccg tattcgtgga accgggctgc acgcatagtg gtctgcctta ctttgacggg
     1921 ccggaatgac gtgttcatcc gacgcccgtc actctaaaac ctgacgttga cgtgaggtgc
     1981 aagtcgcaac tgccgcccgg ccggaggagg gcaggcgcgg atgggtgagg ttgccgagcg
     2041 ggcgggggtg agcgtggggg cctgcgccac tacgaggggt cacgccgccc gtcacggtcg
     2101 gcacccatgt gccctctggc aggctcagcg atcccggcac gacgcgagga ctgacgtgcg
     2161 tacgtgaacc gcgtgaacgc cctcggtccg ccaccaggac atgatcgatc tcggcgccgg
     2221 caacggttgc gatcggccac cagggctgcc cccggagccg gtattgctag cctgaacctg
     2281 acgtcaacgt gaggtacgag cgggaaggga gtggcctgcg tcatgcgcat cggacagctc
     2341 gccaggcggt caggggtcag cgtgcgggcc ctgcgctact acgaggaaca gcggctcctg
     2401 gaatcgacgc ggacgcccgg tgggcagcgt gactatcccg acgaagccct ggagcgggtc
     2461 cagctcatcc aggacctctt cgcggccggc ctttccagcc gtaccgtcgt cgaactcctg
     2521 ccgtgcgtga gcaccggcgt cgcgacactc gccatgctcg accagctcat catcgaacgc
     2581 gaccgcatcg ccgcacgcat ccaggacctg acccgggcca agaccaaact cggccgcgtg
     2641 atcgagaatg tgaccgcggc gaacgttgcg caggactgat caacccgtcg cgaggggtgg
     2701 ggcccgacct gtccggcaac taccgggcgc catcacgcgt gaacaggccc ggtcctcggc
     2761 gaacggtctg cgttgctgaa cggcgcgctg caggccgcct atttcatcat cgggatacgg
     2821 gatacgggat acgggctgcg ggcttggcgg ccggacccat gagcggcttc gacgaggacg
     2881 gcgtcaaccg ggagttcttc ccgtccggcg acctctcggc actgctcgtg gtgaacatcg
     2941 gccgacctga gcggcggtcc ggggagcggc cacgcgggcc tcgcctggcg cacggcgagg
     3001 tgtgtacgac accgtgacgc tgcaccgtcc ggccttcgcc ctggtcacgc gggtgggcga
     3061 gggccagacg ggccctcggg gcgcactgtc tcgcggtacc agcggcccca cttgtccaac
     3121 tcctccgtga tggagtccag gctgtgcccg acatcagtga gcgcgtactc aacccgcggc
     3181 ggcacctcgc ggtacacggt tcgcgtcacc aggccgtcgg cttccagctc ccgtaactgg
     3241 cgggtcagca tgcgctgggt gatgcccggc agcgcgcgcc tgagttcacc gaatcgatgg
     3301 gttcccacga ccagctgctt gagaatggcc agctttcgac atcgacggcg caactgatcg
     3361 ccgcgcgcgc cgcgctcggg ggtcggcgcg gcgatgatca tggcgtccac ggtggcgatc
     3421 atcagggtcg tcttcaccga cgaccgcgaa cgggccgtcg ccatcggcat ctggacagcc
     3481 gcccacagcg tcggcgccac gatcggtccg ctggtcggcg gtctggtcac cgcggagtgg
     3541 ggctggggcg cggtcttcct gatcaacgtc cccgtcatcg tcgtcatcct ggctgtcggc
     3601 acccgggtca tcccagagtc ccgaaacccc gtttcccgcc gctgggacct ggccagtgtg
     3661 gcgctgtcag tcaccggcct ggctggggtg gtctacgcgc tcaagcaggc cggggagcac
     3721 tccggggtga acggcgtcat cgtcaccacg gccgtcgtcg gaagcgtcct gctccacctc
     3781 ttcgtgcgcc gtcagcggcg tatcgccgag ccgctgctgg acttctccct cttccatgaa
     3841 cgccgcttca ccaccgccac cttgtgcgtc atcggctgct tcggctctta cgtcgccctg
     3901 ctgttcttcc tcacccagtg gctccagcag gtgggcgagt actcgccgct gcgcgccgga
     3961 ctcgcactga tgccactggc cggcgccaac gccatcggcg ctgtcacagc gccctgggcc
     4021 gcgaaccggt ggggcaaccg gtgggcgctc accgggacgc tcgccctctt cgccaccgcc
     4081 ctcaccgtca tggccgttgt cggcgacacc gcccactatg gggtgctgct cgtgccgttg
     4141 ctgggcgcgg gatacggcgc cggcatcgtg atgaccctgg gcgccgattc catcatgagc
     4201 gccgcgcagc cggaccgctc cggggaagcg gccgctatcc aggagacgtc cttcgaactg
     4261 ggcgcgggcc ttggcgtcgc cgtcctcggc accgtcctga cggctgtgta ccgaaccggc
     4321 ctgccccagg taccggggct cggcccggac gggcgggcga tggccgagga atcgttcgcg
     4381 cacgccgagg gcctcacggc caaccttccc tccgaaaccg cccagacact gcagcgcgcg
     4441 gcacaacagg cctacgacca cggcttcacc accgtgctga cactcgccgc catcggcctg
     4501 gtcgtcaccg ccgccatggc ggccgtcctg ctgcgcccgc cgaagacgag gtgacggggc
     4561 cgcatcagga ctgcagtgcc cgcgtgtgcc gctgcagggc acgaccaccg cagccggttg
     4621 cttcagccga ctacttcacc ggcaggagcg gcggagtggt gagccggccg ggcggcggga
     4681 gggtgaacgt cggaaggatc agcggcggga gcgacgcctc gggccagacg ttctgcgcgc
     4741 tgggcggcgg ggagaacggt ggtggatcgg tgcggggcgg ggagatgacg gtgtggacga
     4801 agaggctcgc tgccaggacc aggaacattc cgatcagcgt tgtcttgact ttgaaccgca
     4861 ggaacgcccc gctgagccga ggcggtttca tcgacactgt ggcaccggcc tgtgcggggg
     4921 tcgcgcaccg accgggcgca tggcgtcctg taaggcctcg accagctcgg ggaggtcccg
     4981 cagaagaccc gcggcgggag ggcctgcgct cacggccggt cggtgggtgc tgtccgggtc
     5041 gccgtcgggg cacagggctg ccagccggac cgcaagcggc gggtgactgc cgagcccgtc
     5101 cttggagacg atgtccagtg ccgaggttcc cctgccgtcc gcgaagggcc ggcccaccag
     5161 atcggcgagc cggtccgcga agtcccggaa cacgccgtcg ggaagcatca gtcggggcag
     5221 tgacccgacg ccgcccttcc cggccgccgg tgccggtggt ccctccggcc gggcccggtt
     5281 ctcggtgaac tcgtcccaga gcggtgtcag ggcgtgcacg gtccgcaggg cctgcgcgaa
     5341 cgtgtgcgcc ccggcgatcc gggccgccgc ggcgtccgct tctagctcct gactgcgccg
     5401 tacggccaag gtctggcgca ggtacacacc gttgtacgcc ttggtgagtt tcaggagcag
     5461 tcgcaccggc ggtttgacgc tggtctggtc ggtctccagg acctccaggt agcggaccgt
     5521 gcgttccagg gcgacgctgc cgcggcggct gacggcagcc agtcgggtgt gacggcccgc
     5581 gtagtgcccc agttcatggc acaggacggc gcgcagctcg tccctggtga gcccgaggag
     5641 caggggcagg cccaggtcca gggtgcgggg gcctccgatc aggcccagaa gcttgccgcg
     5701 ttcgccggcg taggcgttga cggtgtcggc caggcgcatc gtcgcgggtg cggcggtgcc
     5761 cagctcgtcg gcgagttgca gggtcagagc ccacagttcg ggctgctgtt gcggggtcag
     5821 cacgatccgg gggccttcgg ccacgtcggc ggacgccctg gcgagcagcc cgtaggccag
     5881 ggcggaggtg gggaccacgg tgagggagcc cagcacggcg aactgccagg cattcgtggt
     5941 caggatggcg atgaccagca ggagttgggt ggccaggacg gcgacggcga ggaggtggac
     6001 tccggccagg agggcgcagc cgagcagggc gcgcgacgtg gtcgccgccg gcttcgtccc
     6061 tgtcatttgc gccccgtgcc ttcgcgttgt cggccggcaa ggtctgctcg ggcctgccgc
     6121 ggtgcctgtt cgtcctcctc gaaggccgag cagagccaga actcggtggc gctcagggcc
     6181 gcggcgagcc ggtctccggg cgcggggccg ccggtgccca ccagcgacac ctcgcccagg
     6241 ggatcggtgc ccggggcgag gccgagcatg cgccggaggt tgtcgcgccc cttgcggagg
     6301 ttcccccgtg ccgtggagac cgcgatgttc aggtcatcgg cgatctcctg gtgggtcatg
     6361 gcgtagaggc tgtacatgac cagcaccatc cgctggcgcg gcggcagggc ggccatcgcg
     6421 gtcagcaccc gccgggcctg cgccgtctcg tccggcagtg cctggcgggg cagggccacg
     6481 tccagcgccg cgcgcttaac cttgaggcgc agacgcagcg cgcgccacag ttttctccgc
     6541 atcaccagac tcacccacgc gttcggctgc tcgtagccgc tgatccggtc ccagttctcc
     6601 agcgccgcga ggaaggcgtc ctggacggcg tcctccgcgt cctgacggtt gccgcacagc
     6661 atcaccgccc gggccagcag ggccggacga tgagccgtga agaacacgtc gaagtcgacc
     6721 ggagcgcgtc cgtcctccgc tgcctcgtcg ccacctaccg gtgcgggctc ctgcgcaccg
     6781 gcccggacac tgcccgtccc accgctcatc gtgcttcccc ttcctggccg ctcgacgcgg
     6841 ccaggccatc gccccgcacg gtcaggacgc ccccgtccgg gcggcggtcc tccacctgga
     6901 caccgtgacc cgcctggcgc agcgcggcga gcaccaaccg gccccgttca cgttcacggg
     6961 ccaactctcg ctgccaggcc accacctcga gggcgattct gaccgtagcg gccagtaccg
     7021 cgatcaccac cgattcccac atacccgacc acgtcccctg ccgaccacgt aacgtcagca
     7081 gatgccctgc cgactgcaac accgctgaac acccgtagcg gggcaccgcg tttacccgtc
     7141 gaccggaatc tccttcaggc agtcgggtac gggcgtacgg caaccccgcg ccgggcggcc
     7201 gagggcggtg gtcacgcgcc ggcgatcggg atgccgtcgg ccggcgacgg ccccgccgtc
     7261 agcgtgcgcc ggctgcacgc cccttgttcc gcgagatctc acggcttacc gtcgatgccg
     7321 aacccggcac acccgcgcga gcgcattccg acctcgacgg cggcagcggc ggattcggct
     7381 ggcacatgat ccgccgctgg cctgattccg tgccgagcct gtctccggct acctgggcgg
     7441 atcggtggtc tcggtgtggg agcacatggc gccgctggtt gcagtggaac gggcccggcg
     7501 ggcacacagt gcgctgccgg attccagcag gtggcagctg tacttcgaga atctctacca
     7561 cctggttcgg gagacgcctg ccgagcaggc tcgggcgggg acgccgctgt ggcggctgtc
     7621 cagccggtga cggaccgtcc gtgcaagggt tcgtgcacgc aactctctga gcggtggtga
     7681 atccgacaat tctgtgacag acgtgggtgg ttcgggcagg gtcaggtcat ggtcgctctt
     7741 cgttcccgcc gtccggaagg gctcttcggg gcccggctgg acgcgctctc gtcgtcggca
     7801 cggcgctcgc gtcgcacctc ccagccccgc cgtcggtccg ggcaggcacg ctgaagagcg
     7861 gtccgggatc gcaccgctgc agccctctac ggccgtatcg aacatctcgc tcgttaaatc
     7921 cgccggcggc gcgttcgggc ggccaagcag cggcacgatc cgtcgaaggc cctctccggc
     7981 ttcggcccac agggccatcg gccgctccga ggatccttcg aggacgacgt cgccctccgg
     8041 accttcttcg gtgcggaccc tcgacagagt gccgacgcct tcctcggggt ggtcgggcat
     8101 gaacgcatgg acggtcttgc acccaggcac gtcttccacg ccgaagatgt gcccggtgcc
     8161 cggcggcaag cgccgcactc agatcgtgca actcctggcc gccgccgtcg ttgcgcagtc
     8221 ggaacgtcca cgcagcgggc gcaccatcga cctcggcagg tgagcaagtg aacacgcgcg
     8281 ggttcgcaga atcttggcga gcacaggtga gtaacccgcg cgccggtcgc cggttgggca
     8341 agcggcgtgg acgggttcgc ccacaagcga gccgtgggct tggctgtccg aagtgctttg
     8401 tgtgcctctg gcgccgacgg ccgtcggcat gggcggcgtg tctgtgacgc gtcgcaagcg
     8461 ttaggccatc cggtcacggt cggtccggat gacgaggggg ggaggagacg ggcgtggaga
     8521 tcagggatgt gcatcatgcc taccgccagc gtgtggtctt gcggggcgtt gacctgcggc
     8581 ttcgggccgg aactctgtgc gggatcgtcg gggagaacgg cgccggcaag tccacgctgc
     8641 tgaaaattct gtccggggag ctacggccca cgcatggatc ggtccgtcat agcggccgct
     8701 tcggctactg cccacagcac gtggtcctca atgacgcgct gaccgtccgg cagcacctga
     8761 cgttctttca gacggcctac cgcctcaccg atgtgcgcta cgccgaagag atcatggacg
     8821 tgctgggctt cactggatac gccgatgagc gggccggggt tctcagcggc ggtacgcggc
     8881 agaagttgaa cgtgacgctg gcgctcatgc acgatccgca ggttctgttg ctggacgagc
     8941 cgtatcaggg tttcgactgg gacacctacc agcggttctg ggatctggcc gcgcggctgc
     9001 gggatgcggg acgctcggtc ctggtcgtct cccacctcgc atacgacacc gagcgcctgg
     9061 acgagctgtg gcgcctggac agcggaatgc tgcgcgcgga aaaggcgggg gccgccgcgt
     9121 gaggtttcac ctgacccgct ttgctgtcgc cacccggttc acgctcatcg aacacggccg
     9181 caaccggttc gccatggttc tggtgatcct gttcgtcccg gtgtgggcct ccctggcgta
     9241 cctggcgatg cccgacaccc cgacccggat gcggcttcgc gccaccgggg aagcattggc
     9301 cccgcacggc aatgaactga ccgcgatcag cggagcgctc aacgccgtca ccctgatcac
     9361 cggtttcatg atgttcgccg ccaccttctc cggcagcggc ttcgaccgcc gcctggcgat
     9421 ggccggctac ccccgcgccc acctcgtcct ggcgaaagtc accgctctgg ctctggtctc
     9481 ggcggcggtg gccgcttatg ccaccgcggt catctgcttg gcctggaccc ccgccagcct
     9541 ctgctgctcg ccgcctccct gttctgcgcc ggactcactt acggcgctct gggagtcgtc
     9601 ttcgggtccc tgctgcgccg ggaagtcgag gggatgttcg ccatcgtgat gaccagcatc
     9661 atcgatctcg cgctgcagaa tcccatcacc agttccgggg ccggcaaccc actcatgcgc
     9721 tacctgccct cgtacggggc catgcaggcc agtacagcgg ccggattctc caccagcccg
     9781 gtccccggac atctggccct ccagctgacc tggttcgggc tggccgccct tgtcgccctg
     9841 ctgggcttcc gccacagcac ccgcaactgc ctgccgaccg cctccactgc gccgtccggg
     9901 ccgggaagca gcaagaccga tactcccgca ccgcgccaaa cggccagccc attggccacg
     9961 acgcccgaca cggaagcaca ctgaggtccc agctcccgac atgcacacca ccacgtattc
    10021 cacgacggca gacctcgacg ccgctctgcc ggcacaacga ggccgaccca cccaccaccc
    10081 gcccatcggc gaagccccgt ccctgcgagc ggcgtaccgg ctgtgccggc gcaccacacg
    10141 agtgcatgat cccgggatct acgccctcat ccagctgatg ccgaccgtgc tgcgcccgcc
    10201 ctgctgggcc ttgtgggcgg cagcgagcgt cctggacgac ctcgccgacc agcaagacgc
    10261 tcaacaggcc gaccgggaaa cccgcgtcca agcgtggtcc caagccctgc agtgcgacct
    10321 ggcggccggc accagcgcgg atccggtccg ccatgccctg gtggacaccg ccctgcgatg
    10381 gcgtctggat ctgtccagcc tccaaagcgc catgacaagc acacgcgacg acgtccgagg
    10441 ccagcatttc gccgactggg ccgcgtggcg ggcctggtgc aacggggcaa tcacagcctg
    10501 ggtcgaccag gtacggcacc tgttcgaacg ggccggagcg ccgatgacgt tccggttgga
    10561 ccggcagcag gactacaagc ggttcatcga cggcgcccag ctcaccgaca cactcaccga
    10621 cctcagcgcc gacctcgccc agggcgacct gctcctgccg caggaggccc tggacgcctt
    10681 tcccggcgcc gaggacgacc tgcggcaagg gaacccgttc gaaggcgtgc tgcggctcgc
    10741 gttcccgcgt ccaggcttca ccccttgcac gtggctgacc actgtgtctc gggacgacct
    10801 gatagagcgg gcggccgtcc tgtcctcggc gaagctcagc gagattgacg atgccctccg
    10861 actcgctgaa caagcgcagg agcagacccc ggcgacgacc gcgaagctca gcgagatgag
    10921 ggacgccctc cgtctcggtg aactcgggtg gagggagaag aagccgacgg cgtgggcggt
    10981 ttcggccaga tggtcgccgc tgtccgactg tcgcctcggc gcccctcagc atcgagatca
    11041 cgatctacgg ctggagtgct gacctgctca gttcagctca tgatccgcca actgagattc
    11101 tcggtcacac cagggccatg agatgccccc agggcggtgg tggcacgccg cagggccaag
    11161 ccgcgcggga gcgggtgcgc atgctggccg tcgatgggtt tgcgcggggt gagaagaaca
    11221 cggtgatcgc gagagaactg cgggtcagcg tccggtcggt gcaacattgg cgccggtcct
    11281 ggcgcgaggg agggcgacag gccctgcgcc cgtcggggcc ggccaagcgg ccgaaggtcg
    11341 gcgacagtga cttcgccgtg ctcgaggcac tgtttctgga tggcgcgatg gcgcgatggc
    11401 gcgatggcgc ggggctgggc ggatgagcgg tggacgctct cgcgggtgcg ggtgttgctc
    11461 ggggaccagt tggggatgtc gttgtcgatc cgcggagtgt gggagttgct gcggcggcag
    11521 ggctggtcgt gtcagcagcc tgcccggcgg gcggtcgagc gggacgatgc ggcggtggtc
    11581 ggctgggtga aggagtcctg gccctgggca aagccaccgc ggcggcgctc ggggcatgtt
    11641 tggtcttcga ggacgaggcc gctgtctcga tgacgtcgca ccgcgcacgc acctgggcac
    11701 ccagagggag cacgtccgcg gttcggttca atggcgcttc ccgtggccgc atcccgatgg
    11761 ccacactggt gtgcttcaag gccggcgaac gcagccggct gatctaccgt cctcgcatcc
    11821 agggccatca ccgaggtgcc caccattgct tcacctggca ggactaccga gatcttctcg
    11881 tgcgggctgg ccttcagctc ggcggtcccg tcgtggtgat ctgggacaac ctgaatgtgc
    11941 accgctccag tcgattccgt gagtacgcgg cagagcacga ctggctcacc atcgtccagc
    12001 tgcccagcta tgcgcccgac ctcgatccgg tcgagggcat ctggtccttg ctccggcgcg
    12061 gcactaccgc aacgtcgtct tcaccgaccg cgaccacctc gtcgcatcga tccgcagcgg
    12121 cctgcgccag atccagcgga aaccccacct cgtcgacggt tgcctcgccg aaaccggcct
    12181 ctcactcaat acgacaactc cacggaaagc tgagtaacac ccaagtcgcc gtcggaggac
    12241 cgcagtccga ccggggctta ctcggcgtcg gtgggtaagc cgtcggcaat ccggttgcca
    12301 cccggcaaaa cgcgggtggg gagacacagg tcgtgcgcac ggaccacagt cctatgcgca
    12361 ggcgtcgggc cgctgcatca acggcgtcaa cgaaccaggg cagtactccc tgcacccgta
    12421 gtggaaatga tttcaagaca ccctgagggg cggcctgatg gacagcggcc ggggcgcgcg
    12481 ggaccgcgcg gtcctgacca cgacgtcctg tgccgggacc ggccgaccag ggggcggttt
    12541 cggccatcgt ttggcatgtt cctttcacaa tcatgctcgg tcgggcacgc tgctccactg
    12601 ttcgctccac tccgactcgc accgtctgtt gtcccgggaa gccgacctcg gcgcccggtc
    12661 cccaccgcag aaggagtacg tgtgagaggc atacctcgcg tcaccggaac tcgtggatcc
    12721 ctccccggcg ccctggtcgg cgttaccgcg ctgttgacga ccggcctcct ggccgcaccg
    12781 gccggcgccg ccccgtcgag gcccgacgcc gctgtgcgct cggtctccgt cgacgcacag
    12841 cggcacgccc agcagttctg gacgcccgaa cggatgaagg cggcgacgcc gctcgacctg
    12901 gtgaccgtcg ccgaccgcgt cgaccgcggc tcggctcccg cccaaggccg gaagatcacc
    12961 gtcgacccca ccacgccaaa agcagcaccc gtcgacgcgg gggtcatggc cttccccagc
    13021 ggcggcgggc agtggaccgg cgggggtgcg gtcctctcca cggcggggcg ggtgttcttc
    13081 acctaccagg gccgtacggc gtcctgctcc ggtaacgccg tcaccagctc caacaagagc
    13141 acggtgatca cggcgggcca ctgcgtgaag ctggaagggg cctggcacac caactgggtc
    13201 ttcgtccccg gctaccacga cggccaggcg ccctacggca ggtggaccgc gtcgaagacc
    13261 ctgtccacgc cgcagtggac ggcgagcgag gacatcaact acgacatcgg cgccgccgtc
    13321 gtcgccccgc tggacggaaa gcggttgacg gacgccgtcg gcggacaagg gctggccttc
    13381 aacaccggct acaacctcgc catgtactct ttcggcttcc ccgcggcgtc gccgtacaac
    13441 ggggagaagt tcatctactg cagcggcacc accaaccggg acttcctcct gtccaacgac
    13501 cacggcatga cctgcaacat gaccggcggt tcgagcggcg ggccgtggtt cacgcagttc
    13561 aacgagtcca ccggcgcggg tctgctgtcc tcggtgaaca gcttcaagta caacttccta
    13621 ccgaaccgga tgtacggccc gtacttcggt gccgacgccc agaacctcta ccagacagct
    13681 cagtcgtcct gacgacaggc ccggccgaga cccgcgacca cgggcaccca ccccgatcgt
    13741 ggctctcggc cgggctgcgg atggtgttcc cggtgacggc ctccacagtg cgtccctccc
    13801 gcgctgtcgc tgactgcggc tgggtcggaa gatcaccacg ggcggggaag ccctcggggg
    13861 cgatgaagta cgtgttgagg ccgggtatgt gtcgaggagc tgtgcaccga caccggcacc
    13921 gtcgcgcaga cgcgctgggc gggaataggc ggcggagaac atgtaggcgg cacgaccccg
    13981 aggaggaaca gccgctgggc caagccgatg gtagacgtct ggctggagtt gaggatgagg
    14041 gagggcagga tgggcggcgc ggcgcagccg gggatcgggc gcgctcaccg gtcttgcgcg
    14101 tcggcgggcc gccgcgcccg gccgccgtca gcgcggcggc gacgtccagc aggggacgtc
    14161 ggcgttggag aggtcggggc gggcacggtg caggcgtgcg gggtggagcc acaggccgga
    14221 ggcgtcacgc gcgacatcga caccgacttc cgccaccagc tcgggctcca ccagcatgac
    14281 cttcagcgtc tcccggctgc cccatccggc actgaacgac cagcccctcc atggatgacc
    14341 gcgccgggcc ggggcgagca gtctggcaac cgtgctgcgg cgtcccatac gagcagctcg
    14401 ccgtttatgt gagctaccac atctgtctca tcaacagccc tttatctgag ggccggagtt
    14461 cgtggagagt gcggagcagc acccgacccg gttcagcctc cgaggcggtg tgcaaggtgg
    14521 agcagatctg ccaggtgcag cacccgtccg tcgaagcctg ggagggggac atggagcggc
    14581 tgggtccagc gcgcggggat tgcatccagc ccgtagtacg cccccgcgag gcctccggtc
    14641 accgcggcga cggtgtccgt gtcaccgccg aggtcgatcg ccgcgcgtat cgcgtcttcg
    14701 aagctggttg tggtgcgcag ggcccagacg gcggagccca ggcagggcca gacggcaccg
    14761 ttgaactcgg tcgcctgatc ggggtgccag tcgggcgcga ggacggtggc gtagcggccg
    14821 cggtggtcgg ggtggacaag ggccaggatg tccgggagcg cggcgagggg gtcggtgtcc
    14881 tcgaacgtga ggcggatgag ttcgtggaag atcgcggtgc cctcccaggc cgcgcggtcg
    14941 ccgtgggtga gggcggcgat gcggtgggcc gcatccatgg tggccctctg gccggcgggt
    15001 gcgaagtgaa ccgcggaggt ggatgcccgc atcaaggagc cgtttcctgc ggctcgttgg
    15061 ttgacttgga aatgaatcgc ggcggcgagg tcccagggca tgccgttggt caggacgtcg
    15121 tcggtctgca agccgatgcc cttcggttcc gatgccgccc accgctggaa gcggacgaag
    15181 atgtccggca gatccagtcc gccccgctcc agcagcgact ccgcgaccag gacggccatc
    15241 tgcgtgtcgt cagtggcctc gccggggtcc cagccaccgc ctccgcacat ctcgccaccg
    15301 gcacctggcg cgggaaaccg cgcggagaac gctcccgggg ggccaaactc gaagggggcg
    15361 cccagggcgt cgcccaccgc tgagccgacg accgcgccgg ccgctcgctg aatccgcttc
    15421 attcgcgcag gttatccgcg ccgtgtcgac ggccgcacgg ccctatttcc ttcctcggct
    15481 ccccgaagta tcggcggcga acgcgtctcg tctacggagg tgcacccgcc tgagacacct
    15541 tgggtctgag acacccgtac aggtcacata atcccgtcca gagcggttgc gtccggcagc
    15601 tgcgcggcac cggccccaat ctccggaaac gccggaagca tctgagtgcc acgcctggag
    15661 cgcagcacca cccggcccac gcctggagcg cagcaccacc cggcccgcgc ctggagcgca
    15721 gcaccacccg gcccgcgtcc ccggagagca gggccctgaa cccgtccccc ttcggctcgc
    15781 ctgctcagcc cggcttcaga gccggatcag gcacgggggt ggccagcatc ggctccggcc
    15841 ctggcagcgt ccacgtcgcg caccatgcct tccacctagc ccatcggccg cccgggtgac
    15901 cgccatgacc ggtcttggtc ggggccgtgg tggggcgtga gcggaaccct cgaccatgcc
    15961 gtccccggcg gcgtccacag ctggtcagcc ggtcaccggg tcaagcctcg ccctcggcct
    16021 cgtgcccgga gtcggggcgg ccgggacgat ccgaacgaca gggccagggc agtcgtgatc
    16081 ccgtggacgg gggcgggtcg ccgtgggcgg gtcgccccgc cgcggttacg cgcacgggcg
    16141 tcagcgcgac cgtccgggca cccgggccag cagcgccgcg gtcgcggccg gatgcgtgta
    16201 cggaaaggcg tgcgcccccg gcatgcgcac cgcccggccc tcttctgccc ggcgggccag
    16261 ctcgcgggtc cagtcgggcg ggcagagggc gtcgttctct cccgtcacca cggtgaccgg
    16321 gcaggagacc gaggcgatca catcctcggg cgcgtccgtc tgcgccgagc gcacgcagat
    16381 cgccaggcgc cggggaccgg cggccaggta ggagggcagc agggtcggga cgacgccggg
    16441 ggactcgtgg acggccgtgc gggcgaacgc ggcgagcagc ggccgcacgc ggcgcagccg
    16501 gggcgggaac gtgggagcca acagcaccag ggcccgtacc cgttcgggcc ggcgcagggc
    16561 cgcgtgcaac gccacctggg ctcccgtcga gtgcccggcc agcaccaccg gcccgtccgg
    16621 aacgacggcc agccaccggg ccaccaggtc cgcgagccct tccagcgtct ccgggcaggc
    16681 cggtcccgaa gggtcgccga aacccgggac gtccagcacg cgtaccgctc cggaacgggc
    16741 gcagcgggcc cccgtccgca gcaggtagcc cggcgctccc aggcccggca ccaggaccag
    16801 cgggccgccg tcgccttcgc cctcgtcgag gcgggccgag cccacgctcc tcacgcttgc
    16861 tgacccgacg cggtcatggc ggacgtacgg cggggacccg gctcggtgcg acatgacggg
    16921 cgggttcccg ctccgcgccg gtccatggat cacgagcctg ttcctcgcgc tgacagtgcg
    16981 tggtccggga aggtgagtcg cgcggagtct gggtactcgc ggcgcacagg cgctcacgac
    17041 gatgcgcccc cggcaagaag gccacgacca tgaacacacg tacacccatg acgagtgccc
    17101 gtactcctgt ccagcaggcg gcgctgctgg tgggagcggt gttcttgctg gtgggagtcc
    17161 tggggttcat ccccgggatc accacggact acgacacgat gaagttcgcc tcgcacgatt
    17221 ccggagccga actcttcggg atcttccaga tctccgtcct gcacaacatc gtccatctcc
    17281 tgttcggcgt cgcgggcctc gtcatggccc gtaccgcctc cggcgcccgc acctacctgc
    17341 tggcaggcgg cgccatctat ctggtgctgt ggctgtacgg cctgttcgtc ggccacacca
    17401 gcgacgccaa cttcataccg ctgaacaatg ccgacgactg gctgcacttc gtcctcggca
    17461 tcggcatgat cgcgctcggc gcgctgctca cacggcgcac cgcccggcgg atctgaccgc
    17521 caaagaggtc gagggcatcg cagcggacgg ccgcggcggg tactgcccgc cgcggccgcc
    17581 cggctgtccg ggcgcggggt tccggcaggt cggccccccc gctgctgttg ccgttcgggc
    17641 ggacggggac ctggacgcgc atgaccgacc tccctcgtcg ccgccgactg cggcagaacc
    17701 gggccctgtg gctgctggac cggctggaac ggtaccgagg gccgattcgt tgatcgacac
    17761 gtcgcgggca gggatcacct gtccgcgacg gaggcagccg gaccgccgcc ggcctgcctg
    17821 gtcatgctgg cgggctcgtc ggtcgggtgg tcgccggctc ctagggtgcg gcgctggctg
    17881 ggggcgtcca cggtcccgta gctggtccag gtcggggagg tggctgccgg gcagtgtgac
    17941 gagcaggtgg gcctgggcgg tgcggatgcc gggggctgac gtctgggggc ctgtgcccag
    18001 tgtgcgacgc acctgatcat cgtaggggcg cccctgccgt gtgcggggtg tgcgggccgc
    18061 tcatagtctg ggggtggctc ggggctactg cggaggtttg ccatgccccg aacgatctgg
    18121 tccggtgcca tcagttttgg cctggtcacg gtgccgatca atgtggtcag tgcgacggag
    18181 gaccacagca tccgtttcca ccagtaccac ctcgaggacg gcggccggat ccgtacgcgg
    18241 aaggtgtgcg agctggagga ccgtgaggtg ggccaggggg agatcggcaa gggctacgag
    18301 gtgaccaaga cgcaggtcat cccgatcagt gacgaggagc tgcgggatct gccgctgccg
    18361 acggcgaagt cgatcgagat cgaggcgttc gtaccgctgg agtcggtgga cccgatccgg
    18421 atcggcgagg gctactacct ccagcccgcg ggtcaggtgg cagccaagcc ctacaagctg
    18481 ctgcggcagg cgctggcgag gtcggcgaag gtcgcggtcg ccaaatacgc ctggtcgggg
    18541 cgtgagcggc tggggctgct gcgggtgcgc gacgacgtga tcgtcctgca cgcgatgcgc
    18601 tggcccgacg agatccgcga ccctgccgaa ctgctcccgc cgccggtgga aatctcccag
    18661 gatgagatcg acggcgcgct ggcactgatg gacaccatga cccgcgacga cctggagggc
    18721 gaggagttcc gcgacaccta caccgatgcc ctggcgcagg tgatcgaggc caagcagggc
    18781 gacaagccgc ttccggaggt tccgcaggcg gaggagccgg gcaaggtgct ggatctgatg
    18841 gcggcgttga cggagtcggt gagccgggcg aaggccgccc gcggcgagac gggcgacgcc
    18901 gacgtccacg acctaccgaa gaagcagacg gccgtcaaga agacggcgaa gaagaccccg
    18961 gccggcaaga ccacgcagaa gacgaccgcg tcgaagaaga cggcggcgaa gaagaccgcg
    19021 ggccgcagac cacgcagcgc ctgatgcatc ggacccggcc tcgagagaag aatgtgaagt
    19081 gggctccgtc ctgtgtcccc cgagccggtg cgggaacccg cggcctgccc cggctcgggg
    19141 gtgggaatgt ctgccggcgt gggtgcgttg taggcggcgt ggtggtgaag gggacggtgt
    19201 ccccgggcct cacctattgc ctgcagggaa gatcgttcgg ctgaagccct gcagagcgtt
    19261 ccgccgcgta ggcgaccccc ttcacgacca cactttcgtc gcagcccctg ccccggtgcc
    19321 ccaccacggc aggggctgca catgtgtccg gaaggtgcgt gaccgcgctg cggctggggg
    19381 cgccgtgccg gtcatggacg actgcgcgca ccttgacctt gacgaaatcg ttttcgcgcc
    19441 cgtgcagtac gactaggagc ggatcctctg ctgacgctgg gggaggcccc cgcgccgctc
    19501 agagtcctgc ggacggccgt cgcgcagggc ctcgaggtcc agcgggaacc ggtcggcaaa
    19561 cgcgtcaccg cccgcctcgc cctgcccgac gaccccggcg gatacgtcac cggacgccgc
    19621 ccccattaac agccggcgct cccgtcggcc tcaccaccct ttcctggcgg cctgcctgca
    19681 gcggcgcgct gccggcaggc gagggcggcg gagggaaagg gtcggggcgg ggcctgccgc
    19741 actttacgat cggcgcccca gccgaggtgg cgttcggttt cgtgcacgac ggtgcgccaa
    19801 agcgggagga ggcagaggca gcgcacaaga ccagcgaccg gcgccccttc ctccgtacgt
    19861 gaagcacctg tgcccgaaac cgtcaggatg tgtgtggata ggcttcggcg gtgaccgctg
    19921 atgccgtgga gaagctgctc gctgatgtgt gcgggacgtt ggcccgtgcc ggctttgacg
    19981 tggcgtcggc cggtgatgag ggcagccccg gcctgcgggt gcggagggat acggactcgg
    20041 tgctggtggg atgggtgccc ggcagcgagt tagatcctgc gggccgggag gataccgagt
    20101 tcgagggcat tcgtgcagct ctgcggtcgg cgctgctggc gatcctcacg caagccggtc
    20161 atcccgtgca ggtggaccac gcgagcggtg aggtgcgggt caggctgctt gcatgaccct
    20221 gggccgcggg atcgacccgc gttgccctca gagcgtgggg cagttcgaac gccggcgggc
    20281 ggggcgatgt aggacccgag tcccggagcc ccgcgccgct tcgacgggtc cggcaccctc
    20341 ctgagcgggc agccgactcg ccgcacggcc ctgccgggag cacgctggga ggcgtgacca
    20401 gcgcgccgat cgtcgtacac caaccctccc gaaccggtgg ccggggtgtc accgtgcact
    20461 cgcacggccg ggacgagatc ctcggcaccg cttacagcga ccacgacttg gtggtgtcct
    20521 ttcaagcggc gggcgtcgac gaacccgagg cagtgttgga cgatccgcgg tggatggaat
    20581 ggcgcggagg ccgcccacac gagtggagaa cggcctgagc ggggccgctc caaaccgacc
    20641 gcgcacagtg tggtggcatg gtgtacgggt tcaccgcggc cgcgaggtgc cgttgcgagg
    20701 tt
//
